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  Messages 1-11 from 11 matching the search criteria.
L-Methionine: Supports Glutathione Production And More. Darrell Miller 10/27/22
Using SAMe for Depression Darrell Miller 6/4/11
L-Methionine Darrell Miller 5/2/09
Chronic Fatigue Syndrome and Fibromyalgia Darrell Miller 2/28/07
Mega-Folinic - Bio-Active Form of Folic Acid Darrell Miller 1/31/07
SAMe (S-Adenosylmethionine) Darrell Miller 12/17/05
Is there a cure for chronic fatigue syndrome? Darrell Miller 12/10/05
TMG Fact Sheet Darrell Miller 12/7/05
Research on SAMe.... Darrell Miller 10/26/05
Defeat Depression Darrell Miller 6/13/05
SAMe - Supports Joint Comfort, Function and Mobility ... Darrell Miller 6/6/05



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L-Methionine: Supports Glutathione Production And More.
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Date: October 27, 2022 11:28 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: L-Methionine: Supports Glutathione Production And More.

L-Methionine is an essential amino acid that cannot be manufactured by the body. It must be obtained through diet or supplementation. L-Methionine supports the production of glutathione, and thereby assists in natural detoxification processes. In the body, L-Methionine can also be converted into SAMe (S-Adenosyl Methionine), a compound that supports healthy joints.* Furthermore, the human body relies on ingested sulfur amino acids, such as L-Methionine, for the synthesis of protein, as well as for biologically active sulfur.*

L-Methionine and Glutathione Production

L-Methionine is required for the production of glutathione, which is a cellular radical scavenger.* This means that it helps to protect cells from damage caused by free radicals.* Free radicals are unstable molecules that can damage cells, and they are one of the main causes of aging.* Glutathione is important for detoxification processes in the liver.* It helps to remove toxins and other harmful substances from the body.*

L-Methionine and SAMe Synthesis

L-Methionine can also be converted into SAMe in the body. SAMe is a compound that is involved in many biochemical reactions, including those that occur in joints.* SAMe is thought to play a role in joint health by supporting healthy cartilage and joint function.* In addition, SAMe has been shown to help with depression and liver health.*

The Importance of Sulfur Amino Acids

Sulfur amino acids such as L-Methionine are important for the synthesis of protein in the body. They are also necessary for the production of biotin, a water soluble vitamin that is involved in energy metabolism. Sulfur amino acids are also involved in a number of other important biological processes.*

In Summary:

L-Methionine is an important amino acid with numerous benefits. It plays a role in detoxification, joint health, protein synthesis, and more. Because the body cannot manufacture this amino acid, it must be obtained through diet or supplementation. Including L-Methionine in your diet can help you maintain good health and vitality.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6537)


Using SAMe for Depression
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Date: June 04, 2011 10:15 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Using SAMe for Depression

SAMe, or S-Adenosyl-L-methionine, has been promoted for the treatment of depression and various physical conditions. It is believed to help improve the feeling of well-being and mood, and its use in treating depression is likely connected with that.NOW - SAM-E 2X 200MG   60 TABS 1 Several studies have been carried out, administering SAMe both orally and parenterally with promising results. Some that use it believe it more effective than the more common antidepressants, and unlike most of these it has very few side effects and a very quick onset of action: around 2 weeks in comparison to a month for most others.

A typical study of the many carried out involved 30 subjects taking regular antidepressants but still suffering depression. They were given 0.8 grams SAMe for 2 weeks and then 1.6 grams for 4 weeks. Improvement was obtained in 50% cases and complete remission of symptoms in a total of 43% of the subjects. In another test on 28 subjects, the improvement equaled that of prescription antidepressant drugs.

These significant findings render this over the counter supplement (in the USA) worth taking for anybody that has either no effective help from their regular treatment, or would prefer to try a natural biochemical than a synthetic drug for their condition. You are recommended to refer to your doctor, however, if you intend changing your treatment.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2321)


L-Methionine
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Date: May 02, 2009 11:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: L-Methionine

Methionine is an essential amino acid, meaning that it is not synthesized by the body, and so has to be taken as part of your diet. It also contains sulfur, one of two sulfur-containing amino acids that can form proteins, the other being cysteine. It is a precursor for taurine, which is an aminosulphonic acid, and not strictly an amino acid, which together with cysteine supports the health of your cardiovascular system and helps to eliminate toxins from the body.

Maintenance of Cell Membranes

It is also an important intermediary in the maintenance of cell membranes. Phospholipids are fat-soluble components of the cell membrane, phosphatidylcholine being a very important example. Also known as lecithin, this substance is derived from choline, itself biosynthesized in a chemical pathway involving S-Adenosylmethionine.

This substance is made in the body from ATP (adenosine triphosphate) and methionine with the help of the enzyme methionine adensosyltransferase. Known as SAM (or SAM-e), S-Adenosylmethionine employs a number of metabolic pathways in its reaction, though generally aminopropylation, transmethylation and transsulfuration. These add aminopropyl, sulfo and methyl groups to a number of substances, the most common being the methylation of proteins, nucleic acids and lipids.

Phosphatidylcholine is produced by the enzyme-catalyzed sequential methylation of phosphatidylethanolamine, SAM donating the methyl groups. The maintenance of the integrity of the cellular membrane by phosphatidylcholine is critical to all of the basic processes in human biology, including communication between cells, flow of information and bioenergetics.

A by-product of this reaction is homocysteine, formed in the liver from the S-Adenosylhomocysteine that SAM is changed to after donating methyl groups. Excess homocysteine in the blood can create the risk of myocardial infarction and cardiovascular disease. SAM is also of use in the treatment of depression and of arthritis.

Muscle Development

Creatine is a substance well known to athletes as being useful in provide short-term energy for high-intensity training. Although available in the diet, about 50% creatine used by the body is biosynthesized from methionine and two other amino acids, glycine and arginine. It allows a burst of energy lasting about 10 seconds, carried out without the use of glycogen reserves or fatty tissue.

Glycine and arginine combine to release ornithine as a by-product, and form guanidino acetate. SAM donates a methyl group to the latter to form creatine, about 95% of which is then stored in the skeletal muscle tissue. The stored creatine phosphate has the effect of allowing the muscle cells to hold more water, which also enables an enhanced level of protein synthesis, and hence an increase in muscle bulk, which also results from the increased blood flow resulting from the short-term high-intensity exercise that creatine allows.

Creatine can also increase the levels of MRF4 (myogenic transcription factor), resulting in an increasing in the myonuclei provided by satellite cells to damaged muscle tissue, that not only repair damaged muscle fibers, but also increase their ability to grow.

Detoxification of the Liver

Substances that help the liver to process fats, or lipids, are known as lipotropic, and the important lipotropics in human biochemistry are imositol, betaine, choline and methionine. They prevent fat from accumulating in the liver, and methionine is also useful in its effect of glutathione. This is a substance that helps the liver to neutralize toxins, such as excessive doses of acetaminophen, and its supplies are regulated by methionine.

Methionine and Autism

Research into autism is closely studying the Methionine/Glutathione Transsulfuration Pathway. This pathway is a very important biochemical means of detoxification, whereby toxins are methylated and then excreted. This pathway seems to be disrupted in autistic individuals.

Not only that, but disruption can lead to oxidative stress which results in many health problems. An example of this is the build-up of the oxidant homocysteine when there is insufficient Vitamin B6 to convert it into cysteine. This has been discussed previously, and is discussed again below.

Miscellaneous Benefits

Although research is in its infancy, it appears that AIDS sufferers also have decreased levels of methionine in their blood. It is believed that the process of AIDS could be linked to this, particularly the dementia that can occur as a result of the deterioration of the nervous system.

It is also hoped that it can help with some symptoms of Parkinson's disease, and pancreatitis. Initial research into this use of methionine has been very promising, as are studies into its use for urinary tract infections. It appears to operate like cranberry in this respect, preventing bacteria from attaching to the cell walls and multiplying in the urinary tract.

Methionine is believed to be essential for the formation of collagen, and for healthy pliable skin, hair, nails and other forms of connective tissue. For this reason it is often used as a supplement for the treatment of arthritis, although an excess should be avoided for reasons discussed above. S-Adenosylmethionine generates homocysteine during the biosynthesis of phosphatidylcholine, and this can cause cardiovascular problems.

So stick to the recommended doses when you use methionine as a supplement. Used properly, and according to instructions, it offers many health benefits, and can also be used to bulk up your muscle tissue and give increased energy when you need it most.

Dietary sources include fish, eggs, lentils, onions, garlic, meat, seeds, spinach and yoghurt. A good supplement would be from 800mg - 1000mg per day, and is best taken along with a B vitamin complex, or at least folic acid and vitamins B6 and B12, in order to prevent the increased generation of homocysteine.

Methionine also promotes the excretion of estrogen, so is a possible supplement for women on oral contraceptives that lower the production of this hormone. The elderly might also benefit from a supplement although, if taken for any specific condition, your health professional should be consulted first, as they should be for any supplement.

Nevertheless, methionine is a very useful supplement, and can be taken to prevent a large number of conditions. Research is continuing on its effect on AIDS patients, and Parkinson's, and it is hopeful that it will one day be recommended to help people suffering from these conditions.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2002)


Chronic Fatigue Syndrome and Fibromyalgia
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Date: February 28, 2007 12:02 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Chronic Fatigue Syndrome and Fibromyalgia

This is a fast paced world. We are all busy; living our full lives, burning the candle at both ends. We all get tired. We all get sick from time to time and maybe even depressed. But the illness called chronic fatigue syndrome is not like the normal ups and downs that we experience in everyday life. People with chronic fatigue syndrome feel overwhelming fatigue, and often pain as well. This is an illness that does not go away with a few good nights’ sleep. It drags on and on and doesn’t resolve itself. It steals vigor and energy over months, and sometimes even years.

In this issue of Ask the Doctor, we will talk about powerful vitamins, minerals, amino acids, and herbs combined in scientifically validated formulas that people with chronic fatigue syndrome or fibromyalgia can use every day. These nutrients help address some root problems of chronic fatigue syndrome and fibromyalgia by restoring energy and health to sufferers.

Q. What is chronic fatigue syndrome?

A. Chronic fatigue syndrome (CFS) also known as chronic fatigue and immune dysfunction syndrome (CFIDS), or myalgic encephalomyelitis (ME), is a group of symptoms associated with unrelenting and debilitating fatigue. The profound weakness of CFS causes a persistent and substantial reduction in activity level. You feel too tired to do normal activities or are easily exhausted for no apparent reason.

Besides extreme fatigue, symptoms of CFS include general pain, mental fogginess, flu-like symptoms, and gastrointestinal problems. A list of symptoms includes:

  • -Headache
  • -Frequent infections, such as sinus or respiratory infections, swollen glands, bladder infection or yeast infections
  • -Muscle and join aches
  • -Inability to concentrate or “brain fog”
  • -Allergies to foods and medications
  • -Anxiety and depression
  • -Decreased sex drive

The number of symptoms and the severity of these symptoms can vary among people. The symptoms of CFS hand on or reoccur frequently for more than six months.

Q. Are chronic fatigue syndrome and fibromyalgia considered being the same illness?

A. Fibromyalgia syndrome (FMS) is a painful shortening of muscles throughout the body. FMS is basically a sleep disorder characterized by many tender knots in the muscles. These tender knots, called tender or trigger points, are a major cause of the achiness that people with fibromyalgia and CFS feel.

Approximately 80 percent of chronic fatigue syndrome patients have received and overlapping diagnosis of fibromyalgia syndrome. For most people, fibromyalgia and chronic fatigue syndrome are the same illness.

Q. What causes chronic fatigue syndrome?

A. There are many causes that can trigger CFS. Current research is looking at the roles of neuroendocrine dysfunction, viruses, environmental toxins, genetic predisposition, food sensitivities, yeast overgrowth, faulty digestion, or a combination of these factors.

For many people, CFS is triggered by a bout with a viral illness (like a cold or the flu), or even a stressful event. CFS is usually a mix of underlying causes. It is like a domino effect in that each problem can trigger another problem, and so on. For example, fatigue and poor sleep can trigger a weakened immune system, which can, in turn, trigger yeast or bacterial infections.

Q. Who gets chronic fatigue syndrome?

A. CFS is more common than you might expect. It strikes people of all ages, racial, ethnic, and socioeconomic groups. Approximately 800,000 people nationwide have CFS and over six million have fibromyalgia at any given time.

It is important to stress that CFS is a real illness; it is not “just in your head.” Unfortunately, sufferers of CFS may find that many healthcare practitioners discount the symptoms of this illness or misdiagnose it as another disease. This can lead to additional emotional suffering.

Q. How long does chronic fatigue syndrome last?

A. The illness varies greatly in its duration. Some people recover after a year or two. More often, those who recover are more likely to do so three to five years after onset. Yet for some people, the illness seems to simply persist. There are rare cases of spontaneous improvement after five years without undergoing any treatment. However, this is very unusual.

Q. What are the complications of chronic fatigue syndrome?

A. The patterns of CFS vary from individual to individual. However, many common patterns of symptoms are seen in CFS sufferers. These symptoms and problems interact and create new symptoms and problems. For example, infections and disrupted sleep can lead to digestive, hormone, and immune problems.

Infections

The most notorious pattern seen in CFS is the one in which a person suddenly comes down with a flu-like illness that doesn’t go away. These viral or bacterial infections can suppress the body’s master gland, the hypothalamus. Since the hypothalamus controls the other glands, including the adrenals, ovaries, testes, and thyroid, suppression of this gland will lead to a subtle but debilitating decrease in the functioning of all glands and their hormones. Suppressed hypothalamic function from chronic infections can then trigger sleep dysfunction.

Disrupted Sleep

The suppression of the hypothalamus gland can lead to poor sleep because the body confuses its day/night cycles. Because of this, people with CFS have trouble staying in the deep, restorative stages of sleep that “recharge their batteries.”

Poor sleep can cause immune suppression, which may lead to secondary bowel infections. The bowel infections seen in people with CFS can cause decreased absorption of nutrients, which can lead to chronic vitamin and mineral deficiencies.

Q. Is there a cure for chronic fatigue syndrome?

A. Treating chronic fatigue syndrome presents a significant challenge to people with CFS and their healthcare practitioners. Recently, a published placebo-controlled study ( of which I was the lead investigator) showed that when using an integrated treatment approach, over 85 percent of CFS and fibromyalgia patients can improve, often dramatically. The full text of this study can be seen at ‘www.endfatigue.com’. An editorial in the April 2002 issue of the Journal of the American Academy of Pain Management noted that this treatment, which I developed, is now a highly effective and excellent part of the standard of practice for treatment of fibromyalgia. Since this treatment addresses many different problems associated with CFS/FMS, it needs to be individualized to each patient.

Medical Treatments

Medications that provide symptom relief are frequently the first line of treatment chosen by healthcare practitioners for the person with CFS. These include medications for pain, sleep disturbances; digestive problems such as nausea, depression and anxiety, and flu-like symptoms.

However, medications have not been universally successful because they tent to put a bandage on symptoms instead of addressing the root problems. Because of this, medications may need to be supplemented by the other supportive therapies that can address the root problems.

Supportive Treatments

People with CFS/FMS may be depressed, given the catastrophic lifestyle disruption these diseases may cause. They may also feel guilt and frustration because their symptoms were not taken seriously for such a long time. Fear can be a factor as employment and family relationships may be jeopardized by this illness.

Therapies that help people to relax and improve coping skills may be helpful and include counseling for emotional and mental health, cognitive behavioral therapy, sleep management therapy, and massage.

Daily Nutritional Supplementation for Energy

Good overall nutrition is important for everyone, of course. However, there are several vitamins, minerals, and amino acids that can have powerful nutritional effects for a person with CFS. All of the vitamins and minerals in a chronic fatigue/fibromyalgia formula should work together synergistically to help improve energy levels and overall health. Here are some key nutrients to look for in an energy formula:

Vitamins, Minerals & Other Key Ingredients

Vitamin A: Essential for healthy skin and mucous membrane integrity, healthy immune system responses and healthy bone growth and healthy reproductive processes. Vitamin A in the form of beta-carotene is an antioxidant and free radical fighter. Vitamin E: Helps to relieve pain in CFS patients. Can also improve night leg cramps, which interferes with sleep.

Vitamin C: Enhances immune function by increasing natural killer cells, B and T cells. Can prevent chronic bladder infections by acidifying urine.

Vitamin D: Regulates immune functions of monocytes and neutrophils. Neutraphils are white blood cells that ingest invasive bacteria, and act as the first line of defense once bacteria makes it past the skin barrier.

Magnesium: Involved with immune support. Working with malic acid, enhances immune function by increasing natural killer cells. Magnesium is also critical for the relief of muscle pain.

Inositol: Enhances immune function by increasing natural killer cells.

Malic Acid: Working with magnesium, improves energy levels by improving cellular functions. Especially important in muscle metabolism.

Betaine: Works with B vitamins to synthesize amino acids, and acts as a precursor to SAM-e. SAM-e (S-Adenosylmethionine) is a naturally-occurring molecule in the body, and may have an effect on overall mood elevation.

Amino Acids: Glycine, Serine, Taurine, Tyrosine are essential for the production of energy in the body. Also essential for brain function.

Zinc: Supports the immune system by enhancing neutrophils activity and supporting healthy antigen-antibody binding.

Selenium: Supports immune function by enhancing antibody production.

Fructooligosaccharides: Provides nutrition for good bacteria in the intestinal tract, improving digestion and healthy microflora.

All of the vitamins, minerals, and other nutritional supplements on the list are important to ensure recovery from chronic fatigue syndrome. To ensure that your nutritional supplement regimen contains all of these ingredients, look for a powdered supplement formulated specifically for CFS/FMS sufferers that can be reconstituted in a beverage of your choice. A powdered drink mix is a pleasant, easy way to ensure that you are taking all of the needed vitamins, minerals, and amino acids that will give you the needed energy to recover from your illness.

B Vitamin Complex for Energy

In addition to the powdered energy drink mix, it is important that you also take a vitamin B-complex supplement specifically formulated for people with CFS/FMS. The B vitamin formula, which should include niacinamide, thiamin, riboflavin, vitamin B6, folic acid, vitamin B12, pantothenic acid, and choline, is especially important to restore the energy production needs of your body, as well as for mental function. It is also important to make sure that the dosages are high enough CFS/FMS needs. The chart in the next column lists the B vitamins that are critical for people suffering from CFS/FMS.

B Vitamins Effect on Chronic Fatigue Syndrome

Studies have demonstrated that people with CFS/FMS are often deficient in many of the B vitamins, which tends to worsen their symptoms of fatigue and mental “fogginess” and ultimately lead to a weakened immune system.

B vitamins - Effect on Energy

Thiamine (B1) - Essential in the process of energy production. This vitamin also removes lactic acid from muscles, which causes them to be sore in fibromyalgia patients.

Riboflavin (B2) - Riboflavin (vitamin B2) is crucial in the production of body energy. Supports healthy gluthathione reductase activity, which helps maintain gluthathione, a major protector against free radical damage. Vitamin B2 itself also has antioxidant qualities.

Niacinamide(B3) - Essential vitamin that is a component of the body’s energy furnace, helping to improve fatigue and “brain fog”.

Pantothenic Acid (B5) - This vitamin improves adrenal gland function, which will boost energy levels. It can also aid in weight loss by decreasing appetite.

Vitamin B6 - Working along with thiamine, this vitamin is critical in the process of energy production.

Vitamin B12 - Important for brain function and nerve repair. Aids in relieving fatigue symptoms in CFS patients. Folic Acid - Aids in strengthening the immune system, and aids in mental clarity and concentration.

Q. What other supplements can help me with CFS?

A. Many people with CFS/FMS are suffering from adrenal burnout. Adrenal burnout occurs when the adrenal glands are constantly producing cortisol in response to chronic stress like that seen in cases of CFS. Over time, this exhausts the adrenal reserve, meaning the adrenal gland can no longer increase cortisol production in response to stress.

The good news is that changes in our hormone levels can return to normal when stress is decreased. However, in cases of CFS that return to normal can be made much simpler by using a glandular therapy regimen to ensure healthy cortisol levels and adrenal function.

Glandular therapy uses the concentrated forms of bovine (cow) or porcine (pig) glands to improve the health of our glands. Pioneers in the field of endocrinology (the study of hormones) hypothesized that glandular extracts work by providing nutrients the body lacks and thus repairing the malfunctioning gland.

Adrenal Extract

If CFS has left your adrenal glands in a stressed-out state, you should see great results by taking adrenal supplements. Be sure to buy an adrenal extract supplement that contains both whole adrenal and adrenal cortex extracts.

The best adrenal supplement should also contain vitamin C, vitamin B6, L-tyrosine, betaine, pantothenic acid and licorice. Licorice contains glycyrrhizin, which is broken down into glycyrrhizic or glycyrrhetinic acid. This compound inhibits the activity of an enzyme that turns active cortisol into inactive cortisol. While in high amounts (greater than 100 mg of glycyrrhizic acid/day), licorice administration causes hypertension, no such effects have been observed at lower doses. Experts have speculated that inhibition of the cortisol-converting enzyme may reduce cortisol-related symptoms associated with adrenal insufficiency. The adrenal glands use these nutrients to manufacture cortisone and other compounds. It just makes sense to purchase an adrenal supplement with these supportive ingredients.

The Road to Recovery-Adequate Sleep

Disordered sleep is the underlying process that drives many of the symptoms of CFS/FMS. The most effective way to eliminate pain in CFS/FMS is to get seven to nine hours of deep sleep each night.

However, getting adequate sleep is easier said than done for CFS sufferers with underlying fibromyalgia symptoms. The muscle knots of fibromyalgia make it uncomfortable to lie in one position for an extended time, causing difficulty in returning to deep sleep. Because of this, people with CFS/FMS do not stay in deep stages of sleep to recharge their “batteries.” In addition, poor sleep can cause and be caused by the suppression of the hypothalamus gland, which causes the brain to think it is daytime instead of night time.

It may be helpful to use herbal products to promote good quality sleep. There are many natural supplements that are marketed as sleep formulas. To get the best results, it is very important that the right ingredients are in the sleep formula you buy. Therefore, it is important to look for an herbal sleep formula that is especially formulated for people with CFS/FMS. The combination of herbs is important as each herb addresses a different aspect of sleeplessness and muscle tension.

Ingredients - Effect on Sleep

Wild Lettuce - Has been found to have sedative effects.

Hops - Acts as mild sedative and has a sleep-inducing effect. Jamaica Dogwood Has been found to be mildly sedative and is often used for anxiousness.

L-Theanine - Causes significant increases of neurotransimitter concentrations in the brain, which promotes muscle relaxion and improves sleep.

Valerian - This herb has been clinically studied for its ability to improve sleep quality.

Passionflower - This herb eases nervousness and insomnia.

Putting It All Together

After a good night’s rest, a powdered energy drink mix formulated for people with CFS/FMS should be drunk along with a well-balanced breakfast as discussed earlier. In addition to the nutritional beverage mix, a vitamin B complex supplement designed specifically for CFS sufferers, also discussed earlier, containing niacinamide, thiamin, riboflavin, vitamin B6, vitamin B12, pantothenic acid, and choline, should be taken every morning. The nutritional drink mix and the vitamin B complex supplement will ensure that your body has all the vitamins, minerals, amino acids, and other nutrients, to combat your overwhelming fatigue, pain, and “brain fog.” Taking a daily adrenal supplement, like the one discussed earlier, will provide the much-needed (and often depleted) nutrients your body may be lacking, and help you recover lost energy.

Together, these four interventions: sleep formula; morning energy drink; energy B complex supplement; and an adrenal complex- can make an incredible difference that you should begin to notice within 2-3 weeks of starting this program.

Conclusion

Chronic fatigue syndrome and fibromyalgia are complex physical diseases with physical causes. The unrelenting symptoms of fatigue, pain, and mental fogginess can be overwhelming and frightening. Partnering with a healthcare practitioner specializing in CFS and utilizing different medical treatments, supportive therapies, and lifestyle changes are healthy ways to combat chronic fatigue syndrome. And taking nutritional supplements formulated specifically for people with CMS/FMS that help boost energy or help you get a good night’s sleep can give you critical control over the outcome of your illness and set you on the road to recovery.



--
Vitanet wants to help stop CFS ®

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Mega-Folinic - Bio-Active Form of Folic Acid
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Date: January 31, 2007 03:59 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Mega-Folinic - Bio-Active Form of Folic Acid

Mega-Folinic

Bio-Active Form of Folic Acid

  • Through the folate cycle, Mega-Folinic™ helps to produce key methyl groups needed for numerous metabolic functions.
  • Supports DNA synthesis and homocysteine regulation.
  • Supports positive mood and healthy brain and neurological development.
  • Important for red blood cell formation, liver detoxification, and joint health.

Source Naturals MEGA-FOLINIC ™ is a highly bioavailable source of folic acid. Folic acid is shown to benefit the arteries and cardiovascular system by preventing the build-up of the amino acid homocysteine. Folinic acid is already reduced and more rapidly converted into methylfolate (5-MTHF) so it is more active in the conversion of homocysteine to l-methionine. About 20% of the population have genetic difficulty in converting regular folic acid into the active form methylfolate. Through its role in the methylation cycle, it supports production of S-Adenosylmethionine (SAMe), which in turn promotes healthy joints, DNA synthesis, liver detoxification, and a positive mood. Adequate folic acid may reduce a woman’s risk of having a child with a brain or spinal cord birth defect, making it an important supplement for women who are or intend to become pregnant.

1 capsule contains: Folate (as calcium folinate) 800mcg

Suggested Use: 1 tablet daily.

Mega Folinic Bio-Active Form of Folic Acid 800mcg


Folinic acid is more rapidly transformed to 5,10-methylene-THF 
(L-Methyl folate) than folic acid where “the net effect on
tissues of providing folinic acid (Mega Folinic) orally is
essentially the same as feeding the coenzyme 5-MTHF.”
(Metafolin)




--
Buy Mega Folinic at Vitanet ®

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SAMe (S-Adenosylmethionine)
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Date: December 17, 2005 09:42 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: SAMe (S-Adenosylmethionine)

Supports Healthy Nervous System and Joint Function Vital For Over 35 Biochemical Reactions Necessary For Optimum Health Promotes a Healthy Mood

As the building blocks of protein, amino acids are vital to health. Next to water, amino acids in the form of proteins make up the greatest portion of our body weight. They comprise tendons, muscles and ligaments; organs and glands; hair and nails; important bodily fluids, and are a necessary part of every cell in the body.

There are over 20 amino acids, separated into two categories – essential and non-essential. Essential amino acids are those that cannot be manufactured by your body, hence, it is essential that you obtain them from your diet. Non-essential amino acids can be manufactured by your body, however, your body must have the right combination of essential amino acids and supporting nutrients to optimize healthy protein maintenance, so supplementation may be desirable.

Amino acids are not only absolutely integral to life, they can have a profound impact upon how clearly we think and how well we feel.

SAMe (S-Adenosylmethionine)

SAMe (S-Adenosylmethionine) is a naturally occurring combination of the amino acid methionine and ATP (adenosine triphosphate), the body’s primary energy molecule. In this form it is sometimes referred to as “active methionine”. Research indicates that SAMe plays a vital role in nervous system health and normal cognitive function.*

SAMe may support nervous system function by increasing the synthesis and recycling of certain neurotransmitters and enhancing the sensitivity of nerve receptors. SAMe is believed to positively affect a number of neurotransmitters, including serotonin, dopamine, noradrenaline and norepinephrine. Although the mechanism for SAMe’s impact upon neural function is not fully understood, there is no doubt that SAMe’s capacity as a methyl donor is of critical importance.

As a methyl donor SAMe assists the body in the creation of complex organic compounds necessary for normal healthy function. Your body uses these new compounds for numerous purposes, including brain function and detoxification. This process, known as methylation or transmethylation, is vital to your body’s maintenance. SAMe may be the most effective of all methyl donors discovered to date. Research has shown that SAMe is the only methyl donor with the potential to increase transmethylation in the brain, which helps to protect it from homocysteine damage as well as increasing production of glutathione, one of the body’s most effective antioxidants.

Research into the biosynthesis of SAMe has established a clear link between SAMe and folic acid, or folate. Folic Acid has been proven to provide support for healthy nervous system function and a healthy mood, and researchers believe these two nutrients work together to beneficially affect monoamine systems, which directly affect mood and cognitive function.* SAMe has also been shown to improve the synthesis of phospholipids for use in the brain, probably one of the most beneficial effects SAMe has on brain health. The benefits of SAMe extend beyond the brain and throughout the human body. For example, it may also aid in the repair of myelin, the sheath of fatty material that surrounds nerves and nerve cells everywhere in our nervous system. It’s found in all human tissue and organs and is available for use by your body in over 35 different biochemical reactions necessary for optimal health.

SAMe may support joint health through transulfuration, a process that takes a certain amount of sulfur from SAMe to create glucosamine and chondroitin sulfates. This enhances proteoglycan synthesis, the molecule responsible for keeping articular (joint) cartilage lubricated. As mentioned earlier, SAMe is also important for the production of glutathione, a powerful free radical scavenger that defends your body from toxic agents and is necessary for liver detoxification.

SAMe was first isolated in 1952 by G.L. Cantoni at the Laboratory of Cellular Pharmacology at the National Institutes of Health, Bethesda, Maryland. Four years later, Cantoni and a co-worker found that SAMe synthesis involves methionine and ATP. They also found that it exists in the human body only temporarily, making production in a supplemental form difficult. It took nearly ten years until improvements in technology permitted SAMe research to advance. With the discovery of a method to stabilize SAMe that overcame these manufacturing problems, U.S. patents were granted to allow the production of SAMe in a stabilized form.

SAMe in its ion form, as found in human cells, has a very short life span and is rapidly metabolized into other necessary compounds as needed. Therefore, it must be manufactured in a stabilized form to prevent rapid degradation as a supplement. Once tableted, it must be enteric coated to preserve stability.

This technology was not readily available until the 1990’s, hence SAMe’s long road to mainstream popularity. Dr. Joseph Zhou, Director of Laboratory Methods here at NOW, is credited with significantly improving the analytical methodology used to assure potency levels in supplemental SAMe. His work is one of the reasons SAMe is available as a supplemental with stable, guaranteed



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Is there a cure for chronic fatigue syndrome?
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Date: December 10, 2005 03:19 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Is there a cure for chronic fatigue syndrome?

A. Treating chronic fatigue syndrome presents a significant challenge to people with CFS and their healthcare practitioners. Recently, a published placebo-controlled study (of which I was the lead investigator) showed that when using an integrated treatment approach, over 85 percent of CFS and fibromyalgia patients can improve, often dramatically. The full text of this study can be seen at ‘www.endfatigue.com’.

An editorial in the April 2002 issue of the Journal of the American Academy of Pain Management noted that this treatment, which I developed, is now a highly effective and excellent part of the standard of practice for treatment of fibromyalgia. Since this treatment addresses many different problems associated with CFS/FMS, it needs to be individualized to each patient.

Medical Treatments

Medications that provide symptom relief are frequently the first line of treatment chosen by healthcare practitioners for the person with CFS. These include medications for the pain, sleep disturbances’ digestive problems such as nausea, depression and anxiety, and flu-like symptoms.

However, medications have not been universally successful because they tend to put a bandage on symptoms instead of addressing the root problems. Because of this, medications may need to be supplemented by the other supportive therapies that can address the root problems.

Supportive Treatments

People with CFS? FMS may be depressed, given the catastrophic lifestyle disruption these diseases may cause. They may also feel guilt and frustration because their symptoms were not taken seriously for such a long time. Fear can be a factor as employment and family relationships may be jeopardized by this illness.

Therapies that help people to relax and improve coping skills may be helpful and include counseling for emotional and mental health, cognitive behavioral therapy, sleep management therapy, and massage.

Daily Nutritional Supplementation for Energy Good overall nutrition is important for everyone, of course. However, there are several vitamins, minerals, and amino acids that can have powerful nutritional effects for a person with CFS. All of the vitamins and minerals in a chronic fatigue/fibromyalgia formula should work together synergistically to help improve energy levels and overall health. Here are some key nutrients to look for in an energy formula:

Vitamins, Minerals & Other Key Ingredients Vitamin A: Essentail for healthy skin and mucous membrane integrity, healthy immune system responses and healthy bone grown and healthy reproductive processes. Vitamin A in the form of beta-catotene is an antioxidant and free radical fighter.

Vitamin E: Helps to relieve pain in CFS patients. Can also improve night leg cramps, which interferes with sleep.

Vitamin C: Enhances immune function by increasing natural killer cells, B and T cells. Can prevent chronic bladder infections by acidifying urine.

Vitamin D: Regulates immune functions of monocytes and neutrophils. Neutrophils are white blood cells that ingest invasive bacteria, and act as the first line of defense once bacteria makes it past the skin barrier.

Magnesium: Involved with immune support. Working with malic acid, enhances immune function by increasing natural killer cells. Magnesium is also critical for the relief of muscle pain.

Inositol: Enhances immune function by increasing natural killer cells.

Malic Acid: Working with magnesium, improves energy levels by improving cellular functions. Especially important in muscle metabolism.

Betaine: Works with B vitamins to synthesize amino acids, and acts as a precursor to SAM-e. SAM-e (S-Adenosylmethionine) is a naturally-occurring molecule in the body, and may have an effect on overall mood elevation.

Amino Acids: Glycine, Serine, Taurine, Tyrosine are essential for production of energy in the body. Also essential for brain function.

Zinc: Supports the immune system by enhancing neutrophil activity and supporting healthy antigen-antibody binding.

Selenium: Supports immune function by enhancing antibody production.

Fructooligosaccharides: Provides nutrition for good bacteria in the intestinal tract, improving digestion and healthy microflora. All of the vitamins, minerals, and other nutritional supplements on the list are important to ensure recovery from chronic fatigue syndrome. To ensure that your nutritional supplement regimen contains all of these ingredients, look for a powdered supplement formulated specifically for CFS/FMS sufferers that can be reconstituted in a beverage of your choice. A powdered drink mix is a pleasant, easy way to ensure that you are taking all of the needed vitamins, minerals, and amino acids that will give you the needed energy to recover from your illness.

B Vitamin Complex for Energy

In addition to the powdered energy drink mix, it is important that you also take a vitamin B-complex supplement specifically formulated for people with CFS/FMS. The B vitamin formula, which should include niacinamide, thiamin, riboflavin, vitamin B^, folic acid, vitamin B12, pantothenic acid, and choline, is especially important to restore the energy production needs of your body, as well as for mental function. IT is also important to make sure that the dosages are high enough for CFS/FMS needs.

B Vitamins Effect on Chronic Fatigue Syndrome

Studies have demonstrated that people with CFS/FMS are often deficient in many of the B vitamins, which tends to worsen their symptoms of fatigue and mental “fogginess” and ultimately lead to a weakened immune system.



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TMG Fact Sheet
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Date: December 07, 2005 02:13 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: TMG Fact Sheet

TMG Fact Sheet

Neil E. Levin, CCN, DANLA 03/07/05

LIKELY USERS: People with high homocysteine levels; People with risks of developing Alzheimer’s Disease; People needing greater metabolism of fats; People with liver detoxification challenges; People consuming alcohol KEY INGREDIENTS: TMG is composed of three methyl groups attached to a glycine atom. It can “donate” methyl groups.

MAIN PRODUCT FEATURES: TMG is a metabolite of the B vitamin family product called Choline. Choline has 4 methyl groups, TMG has 3 and DMG has 2. These substances plus Folic acid, Vitamin B-12 and SAM-e are all methyl donors. Methyl donors can contribute methyl groups to biological processes such as liver function, detoxification and cellular replication (production of new cells). Methylation protects the kidneys and stimulates production of the fat-transporting molecule l-carnitine.

TMG helps the liver metabolize fats, preventing the accumulation of fats in the liver. It also helps to detoxify chemicals in the liver, while protecting the liver from being damaged by those chemicals.

Methylation with TMG helps to convert the dangerous, inflammatory chemical homocysteine into the amino acid methionine. TMG may lower homocysteine when B-6, B-12 and folic acid cannot.

ADDITIONAL PRODUCT INFORMATION: TMG is also known as Betaine and is a component of Betaine hydrochloride (Betaine HCl), a stomach acid supplement that is very acidic. But Betaine HCl is not used in the same way as TMG. TMG is not highly acidic and will not supplement low stomach acid.

TMG may be useful for autistic children, along with B-6 and magnesium. It may also be useful in strengthening the body’s immune response against pathogenic bacteria. There is very preliminary evidence that TMG and methyl donors may help against some forms of seizures.

DMG has been used as a sports supplement. TMG is 50% more effective than DMG in any application where the methyl groups are useful. Otherwise, they can used interchangeably.

SERVING SIZE & HOW TO TAKE IT: One serving per day, or up to 6,000 mg., as needed.

COMPLEMENTARY PRODUCTS: SAM-e, Milk Thistle (Silymarin), Dr. Verghese’s Liver Detoxifier & Regenerator, Antioxidants, NAC, Homocysteine Regulators, D-Flame, Detox Support

CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement.

People with Parkinson’s or taking L-dopa should not use methyl donors like TMG without a physician’s specific approval and supervision. There are no other known drug interactions with TMG.

This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This is not an official publication by any company, nor has this information been screened or approved by the FDA or any private company.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:

General:

Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49. Review. PMID: 15321791

Methylation:

Barak AJ, Tuma DJ. Betaine, metabolic by-product or vital methylating agent? Life Sci 1983;32:771-4 [review].

Benson R, Crowell B, Hill B, et al. The effects of L-dopa on the activity of methionine adenosyltransferase: relevance to L-dopa therapy and tolerance. Neurochem Res 1993;18:325–30.

Chambers ST. Betaines: their significance for bacteria and the renal tract. Clin Sci 1995;88:25-7 [review].

Charlton CG, Crowell B Jr. Parkinson’s disease-like effects of S-Adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav 1992;43:423–31.

Charlton CG, Mack J. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-Adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Mol Neurobiol 1994;9:149–61.

Cheng H, Gomes-Trolin C, Aquilonius SM, et al. Levels of L-methionine S-Adenosyltransferase activity in erythrocytes and concentrations of S-Adenosylmethionine and S-Adenosylhomocysteine in whole blood of patients with Parkinson’s disease. Exp Neurol 1997;145:580–5.

Crowell BG Jr, Benson R, Shockley D, Charlton CG. S-Adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson’s disease-like symptoms. Behav Neural Biol 1993;59:186–93.

Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].

Homocysteine:

Brosnan JT, Jacobs RL, Stead LM, Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol. 2004;51(2):405-13. Review. PMID: 15218538 Gahl WA, Bernardini I, Chen S, et al. The effect of oral betaine on vertebral body bone density in pyridoxine-non-responsive homocystinuria. J Inherit Metab Dis 1988;11:291-8.

Olthof MR, van Vliet T, Boelsma E, Verhoef P. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003 Dec;133(12):4135-8. PMID: 14652361

Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab. 2005 Feb;6(1):15-22. PMID: 15720203

Schwab U, Torronen A, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa M. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr. 2002 Nov;76(5):961-7. PMID: 12399266

Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].

van Guldener C, Janssen MJ, de Meer K, et al. Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients. J Intern Med 1999;245:175-83.

Wendel U, Bremer HJ. Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency. Eur J Pediatr 1984;142:147-50.

Wilcken DE, Wilcken B, Dudman NP, Tyrrell PA. Homocystinuria—the effects of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med 1983;309:448-53.

Wilcken DE, Dudman NP, Tyrrell PA. Homocystinuria due to cystathionine beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive patients. Metabolism. 1985 Dec;34(12):1115-21. PMID: 3934499

Liver function:

Babucke G, Sarre B. Clinical experience with betain citrate. Med Klin 1973;68:1109-13 [in German].

Barak AJ, Beckenhauer HC, Badakhsh S, Tuma DJ. The effect of betaine in reversing alcoholic steatosis. Alcohol Clin Exp Res 1997;21:1100-2.

Barak AJ, Beckenhauer HC, Matti J, Tuma DJ. Dietary betaine promotes generation of hepatic S-Adenosylmethioine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res 1993;17:552-5.

Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol 1996;13:395-8 [review]. PMID: 8836329

Freed WJ. Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine. Pharmacol Biochem Behav. 1985 Apr;22(4):641-3. PMID: 2581277

Junnila M, Barak AJ, Beckenhauer HC, Rahko T. Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats. Vet Hum Toxicol 1998;40:263-6.

Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003 May;124(5):1488-99. PMID: 12730887

Kettunen H, Tiihonen K, Peuranen S, Saarinen MT, Remus JC. Dietary betaine accumulates in the liver and intestinal tissue and stabilizes the intestinal epithelial structure in healthy and coccidia-infected broiler chicks. Comp Biochem Physiol A Mol Integr Physiol. 2001 Nov;130(4):759-69. PMID: 11691612

Kim SK, Kim YC, Kim YC. Effects of singly administered betaine on hepatotoxicity of chloroform in mice. Food Chem Toxicol 1998;36:655-61.

McCarty MF. Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy. Med Hypotheses. 2000 Sep;55(3):189-94. PMID: 10985907

Murakami T, Nagamura Y, Hirano K. The recovering effect of betaine on carbon tetrachloride-induced liver injury. J Nutr Sci Vitaminol 1998;44:249-55.

Poschl G, Stickel F, Wang XD, Seitz HK. Alcohol and cancer: genetic and nutritional aspects. Proc Nutr Soc. 2004 Feb;63(1):65-71. Review. PMID: 15070439

Semmler F. Treatment of liver diseases, especially of fatty liver with betaine citrate. Ther Ggw 1977;116:2113-24 [in German].

Zapadniuk VI, Panteleimonova TN. [Cholagogic effect of trimethylglycine in normal animals of different ages and in experimental atherosclerosis] Biull Eksp Biol Med. 1987 Jul;104(7):30-2. Russian. PMID: 3620644

Autism & Seizures:

Rimland B. Seizures, Vitamin B6, DMG, and Sudden Speech. Autism Research Review International. 1996;10(2):1.

Roach ES, Carlin L. N,N-dimethylglycine for epilepsy. N Engl J Med. 1982;307:1081-82.

Vitamin B6/DMG. Letters to the Editor, Autism Research Interview International. 1994;8(2):6.

Immunity:

Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med. Apr1990;115(4):481-6.

Safety:

Hoorn AJ. Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions. Mutat Res. 1989 Apr;222(4):343-50. PMID: 2468082



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Research on SAMe....
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Date: October 26, 2005 12:49 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Research on SAMe....

Two groups of researchers have conducted analyses of trials that utilized SAM-e for mood enhancement. One meta-analysis was published in 1994. The researchers analyzed the efficacy of SAM-e in oral or injection forms based on published trials dated between 1973 and 1992. The authors concluded that there was a significant improvement of 17 to 38% seen in trials of SAM-e compared to placebo response. They state that the efficacy of SAM-e was superior to placebo and its administration caused few side effects.5 A second review was published in 2002. The authors analyzed studies in which SAM-e doses ranged from 200 to 1600 mg daily. They also found a significant effect of SAM-e in comparison to placebo, with an evident rapid onset of effect at enhancing mood.6

Promotes Joint Comfort and Mobility*

As a sulfur donor to connective tissue, SAM-e plays a major role in protecting the integrity of cartilage tissue. An in vitro trial assessed the actions of SAM-e in cultured human articular chondrocytes. At a concentration of 10 micrograms/ml, proteoglycan synthesis and sulfate residue incorporation in chondrocytes was shown to be 60% higher than control levels. Based on these results, it was shown that SAM-e has a positive influence on the growth and health of cartilaginous connective tissue.7

In a double-blind trial with 734 individuals with compromised joint health. SAM-e given orally at a dose of 1200 mg daily for 30 days was shown to significantly promote joint comfort compared to placebo, with a high level of tolerability and low incidence of side effects. The researchers concluded that SAM-e is a highly effective supplement for enhancing joint comfort.8

Another trial evaluated the response of individuals experiencing discomfort in the joints to a regimen of 1200 mg SAM-e for 1 week followed by 800 mg for the second week, and then 400 mg for weeks 3 through 8. This open trial of 20, 641 people showed a strong ability of SAM-e to enhance feelings of comfort within the joints. The treatment was rated as “very good” or “good” in 71% of the participants, with an additional 21% rating the treatment effect as “moderate”.9

In a long-term trial lasting 24 months, SAM-e was given to 108 participants with compromised joint function. Individuals were given 600 mg orally per day for the first two weeks followed by 400 mg daily for the remainder of the trial. Individuals experienced significant enhancements in joint comfort, with dramatic improvements noted after 2-4 weeks of treatment. Improvements continued to 6 months and beyond.10

In addition to the above studies, a review was conducted in 1987 to assess the results of SAM-e supplementation in clinical trials for enhancing joint mobility and function. Over 22,000 individuals had participated in the clinical trials that were the subject of this review. The author concluded from his analysis that SAM-e was shown to be highly efficacious, rivaling or surpassing the effectiveness of other treatments, and also possessing a high level of safety.11 Because of this, SAM-e may be the treatment of choice for enhancing joint function.

Supports Liver Health and Detoxification*

SAM-e supplementation can have profound benefits on liver function. These benefits center around its function as the major methyl donor in the liver, as well as its lipotropic activity. SAM-e also enhances the production of the antioxidant glutathione.

A number of trials have been conducted showing the ability of SAM-e to support liver detoxification functions and enhance liver health in individuals susceptible to toxin-induced liver compromise. SAM-e has the ability to normalize liver function by increasing the activity of enzymes needed to upregulate liver detoxification. These effects are comprehensive and rapid. Dosages used in these studies range from 600 mg to 1600 mg daily for 2 months to two years.12,13,14 In these trials, significant benefits of SAM-e supplementation were seen over placebo.

Safety

SAM-e has an excellent safety profile and is considered well-suited for long term use based on multiple clinical trials. Individuals diagnosed with manic depression should avoid SAM-e supplementation, as it may aggravate the manic phase *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Scientific References

1. Agnoli A, Andreoli V, Casacchia M, Cerbo R. Effect of S-Adenosyl-l-methionine (SAMe) upon depressive symptoms. J Psychiatr Res. 1976;13(1):43-54.

2. De Leo D. S-Adenosylmethionine as an antidepressant. Curr Ther Research. 1987;41(6):865-70.

3. Kagan BL, Sultzer DL, Rosenlicht N,Gerner RH. Oral S-Adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 1990 May;147(5):591-5.

4.Salmaggi P,Bressa GM,Nicchia G,Coniglio M,La Greca P,Le Grazie C.Doubleblind, placebo-controlled study of S-Adenosyl-L-methionine in depressed postmenopausal women. Psychother Psychosom. 1993;59(1):34-40.

5. Bressa GM. S-Adenosyl-l-methionine (SAMe) as antidepressant: metaanalysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14. 6.Mischoulon D, Fava M. Role of S-Adenosyl-L-methionine in the treatment of depression: a review of the evidence. Am J Clin Nutr. 2002 Nov;76(5):1158S-61S.

7. Harmand MF, Vilamitjana J,Maloche E, Duphil R, Ducassou D. Effects of Sadenosylmethionine on human articular chondrocyte differentiation. An in vitro study. Am J Med. 1987 Nov 20;83(5A):48-54.

8. Caruso I, . Italian double-blind multicenter study comparing S-Adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease. Am J Med. 1987 Nov 20;83(5A):66-71.

9. Berger R, Nowak H. A new medical approach to the treatment of osteoarthritis. Report of an open phase IV study with ademetionine (Gumbaral). Am J Med. 1987 Nov 20;83(5A):84-8.

10. Konig B. A long-term (two years) clinical trial with S-Adenosylmethionine for the treatment of osteoarthritis. Am J Med. 1987 Nov 20;83(5A):89-94.

11. di Padova C. S-Adenosylmethionine in the treatment of osteoarthritis. Review of the clinical studies. Am J Med. 1987 Nov 20;83(5A):60-5.

12. Frezza M, et al. S-Adenosylmethionine counteracts oral contraceptive hepatotoxicity in women. Am J Med Sci. 1987; 293(4):234-238.

13. Frezza M, Surrenti C, Manzillo G, Fiaccadori F, Bortolini M, Di Padova C. Oral S-Adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study. Gastroenterology. 1990 Jul;99(1):211-5.

14. Mato JM, et al. S-Adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol. 1999 Jun;30(6):1081-9.



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Defeat Depression
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Date: June 13, 2005 01:18 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Defeat Depression

Defeat Depression

by Cal Orey Energy Times, August 2, 1999

Depression plagues the creative and the mundane. The disparate desperate driven to distress by depression include painters, poets, actors and musicians as well as truck drivers, clerks, electricians and physicists. The victim list encompasses Vincent van Gogh, Emily Dickinson, Audrey Hepburn, Virginia Woolf and Ludwig von Beethoven, as well as millions of other sharers of melancholy misery.

More than 17 million American men and women experience depression in one form or another every year, according to the National Mental Health Association (NMHA) in Alexandria, Virginia. This includes the deeply destructive major, or clinical, depression, the wide mood swings of bipolar disorder (manic-depressive illness), and dysthymia, a milder, long-lasting form of emotional suffering.

Twice as Many Women In the depression scenario, women suffer twice as much: Two times as many women as men endure clinical depression, reports the NMHA. The mood-deteriorating effects of the hormonal disruptions women are heir to may be partly to blame.

According to the National Institute of Mental Health (NIMH), about one of 10 Americans wades through at least one depressive swamp sometime during his or her life.

The good news: Research shows that diet and lifestyle can lower your risk of depression.

Birth of the Blues

Nowadays, mounting evidence suggests that depression may result more from physiological factors than psychological woes.

Some of the hidden reasons why you may be depressed include: nutritional deficiencies, exacerbated by overdosing on too much caffeine, sugar, alcohol and high fat foods; allergies; anxiety and chronic stress; and a chemical imbalance in the brain's gray matter. According to the NMHA, people with depression often possess too little or too large a quantity of the neurotransmitters norepinephrine, serotonin and dopamine. Changes in levels of these brain chemicals may cause, or contribute to, clinical depression.

The NMHA also reports that an imbalance of melatonin, a chemical made by the body's pineal gland (located at the base of the brain), contributes to a form of wintertime depression called seasonal affective disorder (SAD). This hormone is made at increased levels in the dark. Therefore, the body may oversupply this hormone during winter's shortened daylight hours.

Plan B

Since the B vitamins are often involved in the production of energy, and a large component of depression may encompass the inability to get out of bed and deal with the world, experts believe that at least some of the signs of depression are linked to B deficiencies. For instance, studies cited in the Encyclopedia of Natural Medicine (Prima) by Michael Murray, ND and Joseph Pizzorno, ND, demonstrate that folate deficiency and lack of vitamin B12 can compromise mental health (Drugs 45, 1993: 623-36; Lancet 336, 1990: 392-5).

Inositol: This vitamin is also part of the B vitamin complex, and it, too, has shown its ability to lift spirits. Research work in Israel shows that daily inositol given to 28 depressed patients for four weeks produced an overall positive effect. (Eur Neuropsychopharmacol 7:2, May 1997: 147-55). Inositol is found in whole, unprocessed grains, citrus fruits (except lemons) and brewer's yeast.

NADH: Allan Magaziner, DO, in his book The Idiot's Complete Guide To Living Longer & Healthier (Alpha), reports that brain energizing NADH, a metabolite of vitamin B3, enhances the production of the key neurotransmitters dopamine, noradrenaline and serotonin. "In a recent clinical trial," he claims, "nearly all patients given NADH for depression reported improvement in their symptoms and the absence of side effects or adverse reactions."

Moody Spotlight

Another substance winning the spotlight for its effect on mood is SAM-e: S-Adenosylmethionine. In New York on February 24, a symposium coordinated by the American Health Foundation met to hear researchers present information from studies of SAM-e's ability to possibly ease depression.

"SAM-e is a natural product. You and I have it but as people age it declines in production in the body. And that's why we believe supplementation in older people is a beneficial means of bringing that back up and helping people that have depression," said the lead symposium researcher, John H. Weisburger, PhD, MD, Director Emeritus, American Health Foundation in Valhalla, New York.

Another researcher, Teodoro Bottiglieri, PhD, Associate Professor of Biomedical Studies and Neurology, Director of Neuropharmacology at Baylor University reported: "SAM-e has been shown to enhance brain dopamine and serotonin neurotransmitter metabolism and receptor function. It may also aid in the repair of myelin that surrounds nerve cells. These mechanisms are likely to be responsible for the antidepressant effect of SAM-e."

(Bottiglieri is co-author with Richard Brown, MD, and Carol Colman of Stop Depression Now, a report on the powers of SAM-e just published by G.P. Putnam's Sons.)

SAM-e was first touted as an antidepressant in Italy in 1973. It's been reported that nearly 40 clinical trials demonstrate its beneficial effects as a natural antidepressant.

For instance, an analysis of more than 1000 people suffering depression showed that the effect of antidepressants in patients taking SAM-e was 17% to 38% better than dummy preparations. Conventional antidepressants show a 20% effectiveness rate (Bressa G. Acta Neurol Scand S154, 1994: 7-14).

5-HTP: Another popular supplement to boost mood and relieve depression is hydroxytryptophan. "This medication is actually a brain chemical that is metabolized from tryptophan into serotonin," says Magaziner. And since low serotonin levels have been linked with depression, and certain prescribed medications may up serotonin levels, 5-HTP is in demand.

"One of the more impressive studies supporting the efficacy of 5-HTP for depression evaluated 100 people who had previously found conventional antidepressant therapy to be inadequate. Forty-three of these folks reported a complete recovery, and eight showed significant improvement," reports Magaziner. Not only has 5-HTP been shown to work slightly better than drugs known as SSRIs (these include Prozac), he adds, it has fewer side effects than standard antidepressants, too. DHEA: Medical experts also believe that levels of the hormone DHEA (dehydroepiandrosterone) may influence mood. Ray Sahelian, MD, in his book All About DHEA (Avery) reports an interesting study conducted by Dr. Owen Wolkowitz of the Department of Psychiatry, University of California, San Francisco. A group of six depressed middle-aged and elderly individuals who took DHEA found that within a month they had better memory and mood. (Biological Psychiatry 41, 1997: 311-18.) "In addition," adds Sahelian, "other studies have also found that DHEA increases energy levels and a sense of well being." But follow package directions: Some people complain of greater irritability and overstimulation with DHEA, when they take large amounts.

Herbal Relief

St. John's wort: still the most touted natural therapy for defeating depression. In Europe, 23 clinical studies, reviewed in the August 3, 1996 British Medical Journal, found that this herb, also known as Hypericum perforatum, can be helpful in alleviating cases of mild to moderate depression. The work, which included 757 patients, has shown that hypericum produced fewer side effects than conventional anti-depressants.

Although experts have never satisfactorily explained exactly how St. John's wort benefits the brain, some theorize that it boosts serotonin levels. And it can help SAD sufferers.

"In a recent study of 20 people with SAD, four weeks' worth of St. John's wort significantly alleviated feelings of depression. Those people who added full-spectrum lights to the treatment program gained an even greater benefit," notes Dr. Magaziner.

Valerian: Anxiety and stress, which can cause depression and insomnia, may be helped by this herb, says the prolific Dr. Sahelian in his book Kava: The Miracle Antianxiety Herb (St. Martin's). In 101 Medicinal Herbs (Interweave), Steven Foster reports that "Ten controlled clinical studies have been published on valerian...one of which suggests that valerian should be used for two to four weeks before daily mood and sleep patterns improve."

Amino Acid Help

Amino acids, the building blocks of protein, may also help improve mood. (For more on protein, see page 65.) These chemicals are used by the body to construct neurotransmitters, brain chemicals that facilitate mental activity.

For instance, the amino acid L-tyrosine is necessary for the formation of transmitters adrenaline and dopamine. This substance, therefore, is given to alleviate depression and anxiety.

The substance L-dopa which is given to victims of Parkinson's disease is concocted from tyrosine. And several antidepressants alleviate bad moods by boosting the interaction of brain chemicals related to tyrosine.

In addition, since tyrosine is used to make adrenaline, this amino acid may be helpful for folks trying to cope with the mood problems related to stress.

Another amino acid that experts believe useful for better moods, L-methionine, is used by the body to make choline, a crucial substance for brain function. (Choline goes into the formation of acetylcholine, a neurotransmitter.)

Methionine has been given to people suffering from schizophrenia and depression as well as to those with Parkinson's. Methionine plays a number of crucial roles in the brain and body since it helps form other vital proteins.

Depressive Smoking

For those concerned about preserving a positive mood, researchers are positive that smoking worsens depression. A study at the Department of Behavioral Services at the Henry Ford Health System in Michigan found that daily smokers run twice the risk for major depression compared to those who only smoked occasionally.

Unfortunately, the investigators found that not only did smoking seem to lead to depression, depression, in turn, led to more smoking (Archives of General Psychiatry, 2/99).

"Smokers who have depression tend to see their smoking become a daily habit and it may be because they use nicotine to medicate their depressed mood," reported Naomi Breslau, PhD, who headed the research. Over a five year period, the researchers looked at about a thousand young people aged 21 to 30. They found that daily smokers generally start smoking in adolescence, and those who report early depression are three times as likely to eventually become daily smokers.

If you're feeling down, don't give up hope. Although depression can prove to be a depressingly complicated malady, daily, healthy habits can offset its effects. Getting consistent exercise, dousing your cigarettes and turning to herbal and nutritional help to treat mild depression may defeat those blues.



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SAMe - Supports Joint Comfort, Function and Mobility ...
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Date: June 06, 2005 08:30 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: SAMe - Supports Joint Comfort, Function and Mobility ...

SAMe (S-Adenosyl-L-methionine)

You’ve read about it in the media. Europeans have experienced its health benefits for two decades. Now consumers in the United States have access to a nutrient with groundbreaking potential. SAMe, a natural compound formed in our bodies from the amino acid methionine, is stirring excitement due to its wide-ranging health effects. SAMe plays a critical role in cartilage formation. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. SAMe has also been found to support a positive outlook. It affects the synthesis and activation of proteins such as mood-boosting neurotransmitters.

Cutting-Edge Nutrition

Technological advances have made possible the production of stable, bioavailable forms of a natural nutrient with broad-range potential. Source Naturals now offers you the fruits of that technology.

A Multipurpose Nutrient

SAMe, or S-Adenosyl L-methionine, is formed when our bodies combine the amino acid L-methionine with ATP, the primary energy-carrying molecule in our cells. SAMe is a multipurpose nutrient, which is present in every living cell. Because SAMe is involved in so many vital processes, it is important that our bodies produce sufficient SAMe. However, SAMe levels tend to decline with age, and also can be affected by dietary imbalances. To produce adequate amounts, we need to consume not only methionine-containing protein foods, but also foods rich in vitamins B-6, B-12 and folic acid, which are needed to ensure the synthesis of SAMe. SAMe also is a highly unstable molecule. A lot of scientific research was needed to make it available as a supplement. Source Naturals has studied the research and offers this vital nutrient in a form your body can use.

Methylation is the Key

SAMe is known as a “methyl donor.” This means that it works by giving up a piece of itself (a methyl group consisting of one carbon and three hydrogen atoms) to other molecules. This methylation process affects the synthesis, activation and metabolism of various hormones, neurotransmitters, phospholipids, nucleic acids, proteins and other biological molecules. Methylation plays a part in many critical functions, including the maintenance of cell membranes, the removal of toxic substances from the body and the production of mood-boosting neurotransmitters such as dopamine and serotonin.

Effective Joint Support

SAMe has been used in Europe for two decades for joint support. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. SAMe is important in a process called transsulfuration. The breakdown of SAMe generates sulfate groups that help maintain joint cartilage. SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage.

Promotes Mental Well-Being

Studies also show that SAMe helps support a positive outlook. Although the mechanism by which SAMe promotes mental well-being is not known, we do know it is able to cross the blood-brain barrier, where it affects the production of mood-boosting neurotransmitters.

Clinically Researched Potency

Source Naturals SAME is offered in the clinically researched potency of 400 mg per suggested daily use (two tablets). The tablets are enteric coated and blister packed to prevent breakdown and inactivation of ingredients. Source Naturals SAME is available in 20-tablet boxes.

References:
Berger, R. et al. 1987. “A New Medical Approach....” The American Journal of Medicine; 83(5A): 84-88. Carney, MWP et al. 1987. “S-Adenosylmethionine....” The American Journal of Medicine; 83(5A): 104-106. Konig, B. 1987. “A long-term (two years) clinical trial of oral S-Adenosylmethionine....” The American Journal of Medicine; 83(5A): 89-94. Stramentinoli, G. 1987. “Pharmacological aspects of S-Adenosylmethionine.” The American Journal of Medicine; 83(5A):35-42



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