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Green Gorilla's CBD Brand Establishes Operations in South America
August 06, 2017 07:14 AM
Green Gorilla is a CBD brand that has found tremendous success in North America as the health benefits of CBD are being uncovered more by the day. The success for this company has been so great, in fact, they are now operating in South America. Talk about a major transition, but one that is very well welcomed for Green Gorilla. Read this article to learn more about the new operations in South America, and what this means for the CBD industry.
Read more: Green Gorilla's CBD Brand Establishes Operations in South America
Diabetes management: How lifestyle, daily routine affect blood sugar
May 17, 2017 08:45 AM
If you have diabetes, you'll need to learn about and control several factors in your life if you want to control your blod sugar. Eat low carb, small portion meals timed around when you need your medicine. Stay hydrated and avoid sugary drinks. Develop an exercise plan with your doctor, then make an exercise schedule to incorporate it into your life. Frequently check your blood sugar, store your insulin propertly, and keep your doctor updated on any changes. Don't make changes to your diet or your insulin intake when you are ill. Talk to your doctor before drinking alcohol. Watch for cycles of erratic blood sugar during menstruation or if you have menopause. Lastly, log your stress level every time you take your insulin.
"As much as possible, plan for every meal to have a good mix of starches, fruits and vegetables, proteins and fats."
Read more: http://www.mayoclinic.org/diseases-conditions/diabetes/in-depth/diabetes-management/art-20047963
New Research Reports That Certain Foods Can Be The Source Of Skin Issues -
April 29, 2017 08:44 AM
For those who has been looking for ways to define skin aging and make skin young and avoid wrinkles, there has been a great way to do so without using cream, or plastic surgery to achieve this. This method has been clearly described by Dr. Danielpour in his instructional video where he discuss the why and how to keep skin young without relying on unnatural method, by revealing this trick in this video, anyone who is interested can learn about this method.
Read more: New Research Reports That Certain Foods Can Be The Source Of Skin Issues -
Why You May Want to Drink Water Before Coffee in the Morning
April 28, 2017 06:59 AM
Start your day off with a big glass of water. Beginning your day with hydration helps improve your body functions. Over fifty percent of your body is made of water. Adding a glass of water to your morning ritual help a energize your bodily functions. It helps jumpstart your metabolism, encourages bowel regularity, and eases digestion. It can also stave off hunger cravings and increase your alertness. Staying hydrated also helps with your energy levels. Keep a glass of water handy to increase your overall health.
Read more: Why You May Want to Drink Water Before Coffee in the Morning
This Cancer-Causing Chemical May Be in Potatoes, Cereal and Your Morning Coffee, Too
March 15, 2017 11:59 AM
Acrylamide, a chemical created when carbohydrate rich foods are cooked at high temperatures can be found in potato chips, French fries, cereal, toast and coffee among other foods. The chemical has been shown to cause cancer in animals with mixed studies in humans. It can be avoided by shortening cooking times or boiling instead of frying or baking/broiling and don't overcook your food. Soak your potatoes before cooking and avoid potato chips. Keep in mind it firms from plant-based foods so be aware when you cook these types of foods
"In November 2013, the U.S. Food and Drug Administration (FDA) issued a consumer update advising people to reduce consumption of foods in which acrylamide is plentiful, noting this toxic byproduct is found in 40 percent of calories consumed by the average American."
Listeria and its prevention
The only way to get rid of Listeria is by cooking and pasteurisation. To avoid coming in contact with Listeria, you need to wash the fruits and vegetables thoroughly before eating them. For the vegetables which grow under the soil, like beetroot and potato, it is advisable to cook them at a high temperature or boil them before consuming.
It is also critical to keep everything used in the process of preparing food spotless and disinfected. Washing hands before eating and cooking is necessary too.
These precautions can help you avoid listeria from entering your body.
The Benefits That We Can Get From Using Collagen Skin Creams
March 18, 2014 10:49 AM
It is safe to say that you are starting to perceive scarcely discernible differences all over? Assuming that yes then now is the right time to act now before it gets most noticeably awful. It's fortunate that a couple of against maturing medications offer to improve the look of your face, neck and hands. One of the numerous options will be collagen skin cream. Might it be able to generate a change to your health or it is simply a plain trick?
Do you know what collagen is? And in addition what it can do on your epidermis? Adequately, it is one of the fundamental proteins and one of imperative establishments of your skin to help keep lines and different indications of maturing endlessly. More level levels of collagen and elastin are normally significant reasons setting off your skin to look wrinkled and listing.
Observe that collagen skin creams ought to be clear of man-made additives notwithstanding included scents, essentially on the grounds that these are several purposes for touchy response. So rather than these fixings, it must have regular elements and cancer prevention agents like immaculate vitamin e which is an amazing fixing and it is helpful to skin's health. Numerous organizations dodge common kind essentially on the grounds that it takes more.
What is Bioperine and How Does It Help with Absorption of Vitamins
April 21, 2011 03:14 PM
Get more from your food with Bioperine.
Bioperine is a patented form of an alkaloid found in black pepper. It is derived entirely from piperine, an organic compound responsible for the spicy taste of black pepper and long pepper. Piperine has been noted for its thermogenic properties believed to speed up the absorption metabolism of digested foods. Recent studies have discovered that it also interferes with the release of enzymes that govern the bioavailability of drugs and supplements. By so doing, it enhances the rate of absorption of vitamins.
The human body has a complex mechanism of controlling the substances that get in and out of systemic circulation. The first pass occurs in the alimentary canal, where gastrointestinal enzymes break down substances into smaller compounds. It is believed that a very small percentage manages to undergo intestinal absorption after digestion. In general, this is the part where constituents of supplements remain undigested and instead enter the colon together with waste materials.
The liver plays a central role to the metabolism of drugs and most bioactive compounds. The compounds that pass the intestinal walls and enter the hepatic portal system, a group of veins that direct blood and other compounds from the gastrointestinal tract to the liver, is further metabolized inside the liver. Anything that the body considers foreign is sent to the kidneys and easily excreted through the urine. This is the reason why bioavailability is significantly reduced after ingestion.
Counteracts Effects of Enzymes
Bioperine is the only compound known to interact with enzymes that controls the metabolism of foreign materials within the intestinal epithelium. P-glycoprotein is released in the digestive tract to deal with drugs and xenobiotics found in our diet. Vitamins are no exception to the tightly regulated process of absorption in the intestines. These enzymes transport digested compounds to the liver.
It has been observed that piperine appears to reduce the expression of p-glycoprotein in the alimentary canal and other parts of the body. Proponents believe that bioperine, a purer form of piperine, is capable of counteracting the effects of the enzyme within the intestinal epithelium, making it easier for vitamins and supplements to enter the hepatic portal system.
Increases the Rate of Metabolism
Not all compounds that undergo the first-pass effect interact with the cells and tissues they are supposed to act on. If they should have an effect on any cell, they are still subjected to the actions of enzymes specialized for the expulsion of xenobiotics found in the systemic circulation and the rest of the body. For example, CYP3A4 removes foreign materials from the cells and facilitates their excretion.
Bioperine is touted to induce thermogenesis and stimulate cellular activities. By so doing, the effects of bioactive compounds are achieved while they remain inside the cells and tissues. The thermogenic properties of bioperine influence the rate of metabolism of digested compounds, including vitamins, minerals, and components of herbal preparations. Note that it can increase the update or prescription medications as well, so caution should be observed when consuming bioperine with medications.
If you want to give your body a nutrient boost, add bioperine to your supplement regiment to boost absorption.
NPA Loby Day
April 29, 2009 04:12 PM
NOW Takes Top Honors in 3 Distinct Categories On March 24th, 2009 a large contingent of individuals from the Natural Products Association (NPA) visited Capitol Hill during Natural Products Day to lobby Congress on behalf of our industry. Among this contingent were seventeen individuals from the state of Illinois, including three from NOW Foods – President Al Powers, Mike Richard, and Truth Advocate Neil Levin. NOW had two goals during Lobby Day; to meet and lobby Illinois legislators and their staffers on important industry matters, and to obtain contact information for House and Senate lawmakers and their staff for the purpose of extending an invitation to visit and tour our Bloomingdale, Illinois headquarters.
During the day Illinois representatives visited the offices of Illinois senator Richard Durbin and Illinois congressman Bill Foster, and visited with a representative of newly appointed Illinois senator Roland Burris. In regard to legislation, members of the Illinois contingent supported an update to the national school lunch program, which was last revised in 1979, and renewed their support for the Dietary Supplement Health & Education Act (DSHEA), the main body of laws regulating our industry. They also warned Illinois lawmakers that the possible dissolution of the Food and Drug Administration (FDA) into separate Food and Drug agencies could potentially lump natural products regulation together with drug regulation, despite the vastly superior safety record of natural products and dietary supplements.
They also presented information on a number of studies that showed the potential for over $20 billion in healthcare savings over a five year period if consumers were to take certain supplements, including calcium and vitamin D to maintain bone health, lutein and zeaxanthin to support visual function, folic acid to protect from birth defects, and more. Lastly, representatives from NOW Foods opposed new regulations that could hurt businesses that, like NOW Foods, are responble for increasing American exports and creating new jobs for Americans during a protracted economic downturn.
Even though there was no immediate commitment from our representatives in Washington on the key issues discussed, we feel that this Lobby Day was successful in building more personal relationships with our elected officials, and in helping them to understand our industry’spassion and commitment to promoting optimal health for all Americans through the use of safe, high quality natural products.
Interested in learning more about important legislative issues affecting the natural products industry? Visit www.saveoursupplements.organd make sure your voice is heard in the fight to protect American’s access to safe, affordable dietary supplements and natural products.
Lutein 20mg (FloraGlo)
September 26, 2008 03:49 PM
Maintains Healthy Visual Function*
It has been well established that lutein is present in high concentrations in the retinal tissue of the human eye. However, a study was conducted in human volunteers to determine whether taking lutein in supplement form actually increased the density of the carotenoid pigments present in the macula. In this study of eight individuals, researchers estimated the density of the macular pigments prior to having each individual take 10 mg of lutein daily in supplement form for 12 weeks. Plasma lutein concentrations were measured at 4-week intervals. During the first four weeks of the study, plasma levels increased five-fold from pre-supplement measures, and then remained at this level for the duration of the study. It was also shown that, due to increased deposition of lutein in optical tissues, macular pigment density increased by an average of 5.3% at the 4-week mark, and continued to increase until the duration of the study.1
A study was also conducted to investigate the possible role of specific nutrients in protecting the lens of the eye against aging, a risk factor for compromised visual function. The study was comprised of 376 individuals aged from 18 to 75. Of the nutrients measured, it was found that the lenses of individuals with higher concentrations of lutein and zeaxanthin showed less of an effect from the aging process. The investigators concluded that these carotenoids might play a protective role in supporting the maintenance of healthy vision.2
The Age-Related Eye Disease Study (AREDS) was a landmark study of the effects of diet and antioxidant supplementation on eye health. The study enrolled over 3500 subjects aged 55 to 80 years who were followed for approximately 6 years. Among the data collected in this multi-faceted study was a self-administered Food Frequency Questionnaire (FFQ). The AREDS Report No. 22 examined the data from the FFQs and determined that, of the nutrients evaluated, only lutein and zeaxanthin were directly related to maintaining eye health with statistical significance3. These findings corroborated similar results of an earlier multi-center study published in the Journal of the American Medical Association that also found that those with a higher intake of lutein and zeaxanthin maintained healthier eye function.4 These promising results have spurred the design of a second major clinical trial (AREDS2), which is currently enrolling participants to study the impact of supplemental xanthophylls (FloraGLO® Lutein and zeaxanthin) and other nutrients on age-related eye health.5
In addition, a double-blind placebo controlled trial was performed in ninety individuals who had signs of compromised visual function. Individuals were divided into three groups and received either 10 mg FloraGLO® lutein, 10 mg FloraGLO® lutein plus a multivitamin/multimineral formulation, or placebo for 12 months. In both the FloraGLO® lutein and FloraGLO® lutein plus other nutrients groups, improvements were seen in mean eye macular pigment optical density, visual acuity and contrast sensitivity. No improvements were noted in the placebo group.6 These results demonstrate FloraGLO® lutein’s beneficial effect on maintaining healthy visual function.
Newly published research has demonstrated that lutein and zeaxanthin supplementation may enhance visual performance under glare conditions. Forty healthy subjects took daily doses of 10 mg FloraGLO® Lutein plus 2 mg zeaxanthin for six months. They were evaluated for changes in macular pigment, glare disability and photostress recovery at the onset of the study, and at 1, 2, 4 and six months. After six months, subjects experienced an average increase in macular pigment optical density (MPOD) of 39% compared to baseline, and all but two participants experienced some increase in MPOD. This increase in MPOD was also directly related to measured improvements in visual performance after exposure to bright light, as well as photostress recovery.7 This study suggests another way in which lutein and zeaxanthin can help support optimal visual function in healthy individuals.
Potent Antioxidant Protection*
Most of the beneficial effects of lutein are ascribed to its potent free radical scavenging abilities. It is well-known that lutein is a carotenoid related to beta-carotene and possesses antioxidant activity against a number of reactive oxygen species.8
More direct evidence for the free radical scavenging activity of lutein is found in studies of its effects on human lens epithelial cells. Cell cultures were exposed to ultraviolet light after pretreatment with lutein or alpha-tocopherol. Both nutrients were found to reduce ultraviolet-induced damage to lens epithelial cells. However, lutein was shown to have significantly higher photoprotective activity than alpha-tocopherol9 demonstrating its potential as a high-powered antioxidant.
A further review of the mechanisms of lutein in conferring a protective role reveals evidence for its antioxidant activity in various body tissues. Lutein has been shown to be an effective antioxidant in vitro as well as in experimental models of a number of body systems.10
Supports Healthy Skin*
A recent randomized, double blind, placebo-controlled study has demonstrated the positive effects of oral and topical administration of lutein on skin health parameters (surface lipids, hydration, photoprotective activity, skin elasticity and skin lipid peroxidation). Forty female subjects were divided into four treatment groups. Treatment options included oral administration of 5 mg of FloraGLO® Lutein twice daily or placebo and topical administration of 50 ppm FloraGLO® Lutein twice daily or placebo. Each treatment group received either an active oral treatment with a placebo topical treatment, a placebo oral treatment with an active topical treatment, both active treatments, or both placebo treatments. Statistically significant improvements were seen in all five parameters tested in all treatment groups compared to the group receiving only placebos. The greatest overall improvements were seen in the group receiving both active oral and topical treatments, while lesser but still significant improvement was seen in both the active oral only and the active topical only groups. Additionally, oral administration of lutein conferred superior photoprotective activity (as measured by skin surface redness after exposure to ultraviolet light) and prevention of lipid peroxidation (as indicated by levels of malondialdehyde in skin lipids after exposure to ultraviolet light) than either topical lutein or placebo.11
Diverse Cinical Benefits*
Evidence from various experimental trials suggests that lutein may play a protective role on the circulatory and cardiovascular systems. Its antioxidant activity may also extend to the heart, skin, lungs and blood vessels, making it a nutrient with diverse clinical benefits. Lutein possesses the ability to promote the health of many body tissues.12
Suggested Adult Use: One softgel daily with food, or as directed by a health care professional.
Does Not Contain: milk, egg, wheat, sugar, sweeteners, starch, salt, or preservatives.
1. Berendschot TT, et al. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Invest Opthalmol Vis Sci. 2000 Oct; 41(11): 3322-6.
2. Berendschot TT, et al. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Arch Opthalmol. 2002 Dec; 120(12): 1732-7.
3. Age-Related Eye Disease Study Research Group. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol. 2007 Sep; 125(9): 1225-32.
4. Seddon JM, et al. Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration. JAMA. 1994 Nov; 272(18):1413-1420.
5. www.nei.nih.gov/neitrials/viewStudyWeb.aspx?id=120. Clinical Studies Database. Age-Related Eye Disease Study 2 (AREDS2). Last Updated 2/28/2008. Viewed 5/15/2008.
6. Richer S, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr; 75(4): 216-230.
7. Stringham JM and Hammond BR. Macular pigment and visual performance under glare conditions. Optom Vis Sci. 2008 Feb; 85(2):82-8.
8. “Lutein and Zeaxanthin”. PDR Health. www.gettingwell.com/drug_info/nmdrugprofiles/nutsupdrugs/lut_0164.shtml
9. Chitchumroonchokchai C, et al. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. J Nutr. 2004 Dec; 134(12): 3225-32.
10. Krinsky NI. Possible biologic mechanisms for a protective role of xanthophylls. J Nutr. 2002; 132: 540S-542S.
11. Palombo P, et al. Beneficial Long-Term Effects of Combined Oral/Topical Antioxidant Treatment with the Carotenoids Lutein and Zeaxanthin on Human Skin: A Double-Blind, Placebo-Controlled Study. Skin Pharmacol Physiol. 2007; 20: 199-210.
12. Mares-Perlman JA, et al. The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview. J Nutr. 2002; 132: 518S-524S.
Crucial bill S.3546 may soon land in the House of Representatives.
September 19, 2006 11:24 AM
By the time you read this Washington Update, Senate Bill 3546 (S.3546), “The Dietary Supplement and Nonprescription Drug Consumer Act,” may have already passed the Senate. As S.3546 advances to the House for implementation, non-casual Adverse Event Reporting (AER) looms on the horizon. This bill will wrongfully associate safe and beneficial dietary supplements with millions of adverse events that supplements did not cause. As S.3546 targets supplements, it ignores foods that have been linked to millions of annual adverse events—calling into question whether this bill is truly designed to keep us safe. With our right to take vitamins hanging in the balance, we must take immediate action in the House to head off S.3546 as the pass.
S.3546 offers no protection to American people. Instead, this bill appears to inexplicably punish supplement manufacturers and those who choose nutrition as a path to health and well-being. S.3546 attacks our fundamental freedom of choice through guilt by association and will destroy our core freedom to decide how and through which means we pursue health.
Along the way to revoking our health freedom, S.3546 will impose unreasonable reporting requirements that will drain supplement manufacturers’ resources and finances until they collapse. The non-causal AER that S.3546 proposes will unleash a wave of junk lawsuits that will deliver the fatal blow to the supplement industry—making trial lawyers rich while America’s health sinks in the murky waters of malnutrition and sickness.
Association, Not Causation
S.3546 proposed AER for supplements is based on association and not causation—a baldy misguided approach under which supplements will be reported for adverse events even if they did not cause, and had nothing to do with, those adverse events.
Non-causal AER encourages the scourge of our society-junk lawsuit purveyors and ambulance-chasing trial lawyers-to continue exploiting out legal system for their own selfish gains. If S.3546 is implemented, this scourge will blame vitamins for everything from acne to obesity. Americans are already paying for the actions of junk lawsuit scammers, facing ever increasing insurance premiums. With S.3546, Americans will pay an even greater price for junk lawsuits-losing their freedom, their health and their very lives when health-enhancing nutrition is taken away.
Why are safe, natural supplements being singled out, anyway? Dietary supplements rarely, if ever, cause any serious adverse events. The centers for disease control (CDC) estimate that foods cause approximately 76 million illnesses, 325,000 hospitalizations and 5,000 deaths in the United States each year. Despite these figures, no one in Washington is proposing AER for foods. That S.3546 does not include foods is incriminating; it suggests that public safety is not the bill’s ultimate goal. Our enemies in Congress are pushing S.3546, not to protect us, but to destroy supplements-because supplements keep us healthy and healthy people make no money for Big Pharma.
Sending Faxes to the House
After S.3546 is passed in the Senate, it will land in the House of Representatives’ Committee on Energy and Commerce. We must voice our AER opposition to Rep. Joe Barton, the chairman of this key committee, because he will hold the greatest leveraging power when non-causal AER is discussed in the House. Please fax and call Barton (emails and letters are ineffective) and urge him to abolish S.3546 in the name of health freedom.
Please call and send faxes to Barton and other key AER players at the following numbers (fax numbers second): Barton at 202-255-2002, fax:202-225-3052, chairman of the judiciary committee F. James Sensenbrenner, Jr. at 202-225-5101, fax: 202-225-3190; House Majority Leader John Boehner at 202-225-6205, fax: 202-225-5117; Speaker of the House J. Dennis Hastert at 202-225-2976, fax: 202-225-0697; and Congressman Nathan Deal, a member of the Energy and Commerce Committee, at 202-225-5211, Fax: 202-225-8282.
Join the Nutritional Health Alliance (NHA). Visit www.NHA2006.com and take advantage of online tools for easily sending faxes to Congress. Time is running out-please fax and call today and fax and call again tomorrow! With your help, we can preserve the American legacy of health freedom-and keep safe, beneficial nutritional supplements in our lives for generations to come.
An Interview with Congressman Sam Farr, Representing California’s Central Coast.
May 30, 2006 02:36 PM
Ambassador to Health Profile
An Interview with Congressman Sam Farr, Representing California’s Central Coast.
Congressman Sam Farr, a fifth-generation Californian, represents the state’s beautiful central coast. His district encompasses the length of the big Sur coastline in Monterey County, the Monterey Bay National Marine Sanctuary, the Salinas Valley “Salad bowl,” the redwoods, mountains and beaches of Santa Cruz County, and the majestic rural landscape of San Benito County. The health and wealth of this region has been strengthened by Rep. Farr’s focus on the environment, education and the economy. Rep. Farr was raised in Carmel, California and graduated from Willamette University with a BS in biology. He later attended the Monterey Institute of International Studies and the University of Santa Clara. He is fluent in Spanish. As a tough advocate for the health food industry, he has lobbied for strict federal organic standards.
Todd: Congressman Farr, thank you for taking the time to speak with us! Id also like to thank you for all the great things you’ve done for our community, form funding marine sanctuaries and authoring the Ocean’s Act to expanding Pinnacles national Monument. The League of Conservation Voters and others have recognized you as an “Environmental Hero”. And, you’ve worked hard to support the economic vitality of central coast’s $3 billion agriculture industry which includes a substantial organic segment. Our backyard here is also the home of a robust group of nutritional supplement manufacturers. An estimated 187 million Americans are currently taking dietary supplements as part of their daily healthy diet. In California, we’ve got 792 natural product manufacturers and distributors. Where do you stand on the state of our industry?
Congressman Farr: Well, thank you for the introduction and for asking to talk to me about nutritional supplement issues. I am very supportive of this industry and include myself in the 187 million Americans taking dietary supplements. I think supplements offer many safe and viable tools to maintain your health. The continued growth of this industry is an indication of both consumer confidence in the products and the products’ ability to fill the gaps where conventional medical care falls short.
Todd: It is estimated that by 2030, more than 70 million Americans will be over the age of 65 and the cost of health care could reach $16 Trillion per year. A recent study by the Lewin Group showed that by taking certain dietary supplements, seniors can lead healthier, more productive, independent lives while saving billions in reduced hospitalizations and physician services. Do you share our view that a Wellness Revolution is needed to counter the dilemma of an aging population versus shrinking health care support in the future?
Congressman Farr: Our health care system is definitely facing a challenge, especially as the Baby Boomers hit their 60’s and Americans are living longer than ever before. As a Baby Boomer myself, I am well aware of America’s aging population and the impact that will likely have not only on our social institutions but also our fiscal well-being. I agree that dietary supplements do play and will play an even larger role in the future as more seniors look for a way to augment their diets in order to stay healthy and active longer than past generations.
Todd: Our industry is regulated by DSHEA (the Dietary Supplement Health and Education Act), which was passed unanimously by Congress in 1994 to create a reasonable regulatory framework for access to, information about, dietary supplements. But many say that the FDA and DSHEA weren’t adequately funded to do the job as tasked. “Supplements are unregulated” is a false argument we sometimes hear. To ensure that the FDA is able to carry out the law as Congress intended, Representatives Dan Burton (R-Ind.) and Frank Pallone (D-N.J.) introduced H.R. 2485, the DSHEA Full Implementation and Enforcement Act of 2005. Did you support this bill and where does it stand today?
Congressman Farr: I think the DSHEA is a critical law and was proud to support it when Congress considered it in 1993 and 1994. I would certainly support H.R. 2485 if it came up for a vote in Congress. Unfortunately this bill has not moved since it was first introduced and referred to the Subcommittee on health in the house energy and commerce committee. Since this is an election year we have a tight schedule with only about 60 legislative days scheduled before we adjourn. That means it’s likely Congress will only finalize bills such as the appropriation bills that fund government before adjournment.
Todd: Our business climate has included some valid and rigorous challenges to improve our industry, from good manufacturing practices (GMP), to allergy labeling, to implications of Prop-65 in California. It’s disconcerting that a new bill, H.R. 3156 The Dietary Supplement Access and Awareness Act would try to capitalize on misconceptions about the industry. In an era of declining health care and declining insurance coverage, this bill would regulate supplements as prescription drugs. Among other things, it would also require adverse event reports to be turned over to the FDA, even though other foods, including those with identical ingredients, do not have the same requirements. This has the potential to be the next Prop-65-like Lawsuit mill. The result of H.R. 3156 would be chilling. It will knock smaller producers out of the market. It will result in higher prices for all supplements. It will decrease the availability of health-giving supplements to the public. What’s your feeling on this?
Congressman Farr: I am similarly concerned about H.R. 3156 and would oppose it if it came up for a vote in Congress. Like H.R. 2485, this legislation has been referred to a subcommittee on Health in the House Energy and Commerce Committee without any further action. The supplement industry has worked in good faith with the FDA since passage of DSHEA and H.R. 3156 would re-invent a wheel that isn’t needed. Instead, adequate funding as proposed in H.R. 2485 would provide ample oversight for the industry.
Todd: According to a recent study, 72% of the general population believe the government should fund more research on health benefits of nutritional supplements. Do you agreen and what can be done to meet this need?
Congressman Farr: I definitely agree that the federal government should play a bigger role in support of research regarding the health benefits of nutritional supplements. As a member of the House Appropriation Committee, I sit on the subcommittee that has jurisdiction over the FDA’s budget and I know the tight fiscal restraints the agency is under. I’ve worked with my colleagues to provide adequate funding, but it’s an uphill battle especially when we’re in a “robbing Peter to pay Paul” kind of situation. I recommend that people within the industry organize and use your consumer base to actively lobby Congress for additional funds. I’m fond of reminding people that the squeaky wheel gets grease – so let every Congress member and Senator know how much this issue matters to you.
Todd: When there is overwhelming scientific evidence that nutritional supplements provides relief for a disease condition, it currently takes a lawsuit to get the FDA to relent and allow the claim. Even then, the FDA strictly limits the claim and requires a disclaimer that does more harm than good in communicating this important information to the public. There is a new bill, H.R. 4282, The Health Freedom Protection Act that would end FDA and FTC censorship of health information. As an example, the 50% of all adult males who suffer from an enlarged prostate could receive relief from that condition by consuming a simple and safe ingredient, saw palmetto derived from the fruit of the dwarf American palm tree. The FDA censors that information. The public deserves a better opportunity to be informed about omega-3 EFA and heart disease, folic acid and birth defects, phosphatidylserine and cognitive impairment. Do you agree and do you support this bill?
Congressman Farr: I agree the public needs to access to the best information possible so they can make well informed choices about their health. I likely would support H.R. 4282 if it came up for a vote in Congress. Unfortunately this bill is in a similar situation as other we’ve mentioned in this interview – and again because of the tight schedule of an election year, it’s unlikely action will happen this year.
Todd: According to the barometer study, 85% of the US population is currently using some type of dietary supplement. Do you? Looking at your busy schedule from co-chairing the House Oceans Caucus to your seat on the Travel and Tourism Caucus, you are one busy congressman! Are you popping nutritional supplements please tell us!
Congressman Farr: I do take some nutritional supplements, though they vary and since Ginkgo Biloba isn’t among them I cant remember their names off-hand! One product I do use faithfully is Airborne to help me combat germs and colds that I might get from sitting on an airplane. But, like many Americans my life is over-scheduled and combined with the amount of air-travel I do, I find nutritional supplements helpful as I try to stay healthy despite my hectic lifestyle.
Todd: Thank you Congressman Farr! Live long and prosper!
DSEA Release of Health/Cost Impact Study Conducted by the Lewin Group, Initial Results, Wash DC; Nov. 2, 2005
NNFA database. Adam.F on 3-15-06.
DSEA Nutritional Supplement Barometer Study, 2005 Report, Prepared by the Natural Marketing Institute (NMI).
Todd Williams; Source Naturals Marketing Programs Manager.
October 06, 2005 10:08 PM
Magnesium is a dietary mineral with a wide array of biological activities in the body. Magnesium participates in numerous life-essential processes that occur both inside and outside cells. Magnesium deficiency impacts normal physiologic function on many levels. Adequate magnesium is a fundamental requirement for optimum function of the cardiovascular system, the nervous system and skeletal muscle, as well as the uterus and GI tract. Magnesium deficiency can affect health of the heart, bones and blood vessels and alter blood sugar balance .
Magnesium–Important for Everyone, Deficient in Many The average person living in a modern country today very likely consumes less than the optimum amount of magnesium . An abundance of data collected over the last two decades shows a consistent pattern of low magnesium intake in the U.S. This pattern cuts a wide swath across various age-sex groups. The USDA’s Nationwide Food Consumption Survey found that a majority of Americans consumed less than the recommended daily magnesium intake . Twelve age-sex groups were studied and this low magnesium intake was true for all groups except 0 to 5 year olds.
An analysis of the nutrient content of the diets of 7,810 individuals age four and above included magnesium among several nutrients where the amounts supplied by the average diet "were not sufficient to meet recommended standards" . The FDA’s Total Diet study examined the intakes of eleven minerals, including magnesium, among eight age-sex groups. Data was collected four times yearly from 1982 to 1984. Levels of magnesium, calcium, iron, zinc and copper were low for most age-sex groups . Surveys conducted in Europe and in other parts of North America paint a similar picture. Loss of magnesium during food processing is one explanation for this global lack of adequate dietary magnesium .
In particular, the elderly may be susceptible to magnesium deficiency for a variety of reasons, including inadequate magnesium intake, poor absorption due to impaired gastrointestinal function and use of drugs such as diuretics that deplete magnesium from the body . It has recently been theorized that magnesium deficiency may contribute to accelerated aging, through effects on the cardiovascular and nervous systems, as well as muscles and the kidneys .
Women who take both synthetic estrogen and calcium supplements may be at risk for low blood levels of magnesium . Estrogen promotes the transfer of magnesium from blood to soft–tissues. Low blood magnesium may result if the ratio of calcium to magnesium intake exceeds 4 to 1. Magnesium supplementation is thus advisable for women taking estrogen and calcium.
Young adults are not immune to magnesium deficiency. The University of California’s Bogalusa Heart Study collected nutritional data from a cross-sectional sample of 504 young adults between age 19 and 28 . The reported intake of magnesium, along with several other minerals and vitamins, was below the RDA.
Glycine is a highly effective mineral chelator. This is because it is a low-molecular-weight amino acid, hence is easily transported across the intestinal membrane. A study conducted at Weber State University found this particular magnesium glycinate was absorbed up to four times more effectively than typical magnesium supplements.
Magnesium-the Versatile Mineral
The average adult body contains anywhere from about 21 to 28 grams of magnesium. Approximately 60 percent of the body’s magnesium supply is stored in bone. Soft tissue, such as skeletal muscle, contains 38%, leaving only about 1 to 2% of the total body magnesium content in blood plasma and red blood cells. Magnesium in the body may be bound either to proteins or "anions" (negatively charged substances.) About 55% of the body’s magnesium content is in the "ionic" form, which means it carries an electrical charge. Magnesium ions are "cations," ions that carry a positive charge. In its charged state, magnesium functions as one of the mineral "electrolytes."
Magnesium works as a "co-factor" for over 300 enzymatic reactions in the body. Metabolism uses a phosphate containing molecule called "ATP" as its energy source. Magnesium is required for all reactions involving ATP . ATP supplies the energy for physical activity, by releasing energy stored in "phosphate bonds".
Skeletal and heart muscle use up large amounts of ATP. The energy for muscle contraction is released when one of ATP’s phosphate bonds is broken, in a reaction that produces ADP. Phosphate is added back to ADP, re-forming ATP. ATP also powers the cellular "calcium pump" which allows muscle cells to relax. Because it participates in these ATP-controlled processes, magnesium is vitally important for muscle contraction and relaxation. By controlling the flow of sodium, potassium and calcium in and out of cells, magnesium regulates the function of nerves as well as muscles .
Magnesium’s importance for heart health is widely recognized. The heart is the only muscle in the body that generates its own electrical impulses. Through its influence on the heart’s electrical conduction system, magnesium is essential for maintenance of a smooth, regular heartbeat . Magnesium appears to help the heart resist the effects of systemic stress. Magnesium deficiency aggravates cardiac damage due to acute systemic stress (such as caused by infection or trauma), while magnesium supplementation protects the heart against stress . This has been found true even in the absence of an actual magnesium deficit in the body.
Evidence suggests that magnesium may help support mineral bone density in elderly women. In a two-year open, controlled trial, 22 out of a group of 31 postmenopausal women who took daily magnesium supplements showed gains in bone density. A control group of 23 women who declined taking the supplements had decreases in bone density . The dietary intakes of magnesium, potassium, fruit and vegetables are associated with increased bone density in elderly women and men . In an interesting animal study, rats were fed diets with either high or low levels of magnesium. Compared to the high magnesium-fed rats, bone strength and magnesium content of bone decreased in the low-magnesium rats, even though these rats showed no visible signs of magnesium deficiency . While this finding may or may not apply to humans, it raises the possibility that diets supplying low magnesium intakes may contribute to weakening of bone in the elderly.
Maximizing Absorption––Chelated Minerals Explained Mineral absorption occurs mainly in the small intestine. Like any mineral, magnesium may be absorbed as an "ion," a mineral in its elemental state that carries an electric charge. Mineral ions cross the intestinal membrane either through "active transport" by a protein carrier imbedded in the cells lining the membrane inner wall, or by simple diffusion. The magnesium in mineral salts is absorbed in ionic form. However, absorption of ionic minerals can be compromised by any number of factors, including: 1) Low solubility of the starting salt, which inhibits release of the mineral ion, and 2) Binding of the released ion to naturally occurring dietary factors such as phytates, fats and other minerals that form indigestible mineral complexes .
A second absorption mechanism has been discovered for minerals. Experiments have shown that minerals chemically bonded to amino acids (building blocks of protein) are absorbed differently from mineral ions. This has given rise to the introduction of "chelated" minerals as dietary supplements. Mineral amino acid chelates consist of a single atom of elemental mineral that is surrounded by two or more amino acid molecules in a stable, ring-like structure.
Unlike mineral salts, which must be digested by stomach acid before the desired mineral portion can be released and absorbed, mineral chelates are not broken down in the stomach or intestines. Instead, chelates cross the intestinal wall intact, carrying the mineral tightly bound and hidden within the amino acid ring. The mineral is then released into the bloodstream for use by the body. Research by pioneers in the field of mineral chelation and human nutrition indicates that the best-absorbed chelates consist of one mineral atom chelated with two amino acids. This form of chelate is called a "di-peptide." Compared to other chelates, di-peptides have the ideal chemical attributes for optimum absorption . Dipeptide chelates demonstrate superior absorption compared to mineral salts. For example, a magnesium di-peptide chelate was shown to be four times better absorbed than magnesium oxide .
Consumer Alert! Not all "amino acid chelates" are true chelates. In order for a mineral supplement to qualify as a genuine chelate, it must be carefully processed to ensure the mineral is chemically bonded to the amino acids in a stable molecule with the right characteristics. The magnesium bis-glycinate/lysinate in High Absorption Magnesium is a genuine di-peptide chelate ("bis" means "two"). It has a molecular weight of 324 daltons, considerably lower than the upper limit of 800 daltons stated in the definition of "mineral amino acid chelates" adopted by the National Nutritional Foods Association in 1996 .
Bioperine® For Enhanced Absorption Bioperine® is a natural extract derived from black pepper that increases nutrient absorption.* Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine® .
Scientific References 1. Abbott, L.R., R., Clinical manifestations of magnesium deficiency. Miner electrolyte Metab, 1993. 19: p. 314-22. 2. Durlach, J., Recommended dietary amounts of magnesium: Mg RDA. Magnesium Research, 1989. 2(3): p. 195-202. 3. Morgan, K.e.a., Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition, 1985. 4: p. 195-206. 4. Windham, C., Wyse, B., Hurst, R. Hansen, R., Consistency of nutrient consumption patterns in the United States. J AM Diet Assoc, 1981. 78(6): p. 587-95. 5. Pennington, J., Mineral content of foods and total diets: the Selected Minerals in Food Survey, 1982 to 1984. J AM Diet Assoc, 1986. 86(7): p. 876-91. 6. Marier, J., Magnesium Content of the Food Supply in the Modern- Day World. Magnesium, 1986. 5: p. 1-8. 7. Costello, R., Moser-Veillon, P., A review of magnesium intake in the elderly. A cause for concern? Magnesium Research, 1992. 5(1): p. 61-67. 8. Durlach, J., et al., Magnesium status and aging: An update. Magnesium Research, 1997. 11(1): p. 25-42. 9. Seelig, M., Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnesium Research, 1990. 3(3): p. 197-215. 10. Zive, M., et al., Marginal vitamin and mineral intakes of young adults: the Bogalusa Heart Study. J Adolesc, 1996. 19(1): p. 39-47. 11. McLean, R., Magnesium and its therapeutic uses: A review. American Journal of Medicine, 1994. 96: p. 63-76. 12. Graber, T., Role of magnesium in health and disease. Comprehensive Therapy, 1987. 13(1): p. 29-35. 13. Sueta, C., Patterson, J., Adams, K., Antiarrhythmic action of pharmacological administration of magnesium in heart failure: A critical review of new data. Magnesium Research, 1995. 8(4): p. 389- 401. 14. Classen, H.-G., Systemic stress, magnesium status and cardiovascular damage. Magnesium, 1986. 5: p. 105-110. 15. Stendig-Lindberg, G., Tepper, R., Leichter, I., Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnesium Research, 1993. 6(2): p. 155-63. 16. Tucker, K., et al., Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr, 1999. 69(4): p. 727-736. 17. Heroux, O., Peter, D., Tanner, A., Effect of a chronic suboptimal intake of magnesium on magnesium and calcium content of bone and bone strength of the rat. Can J. Physiol. Pharmacol., 1975. 53: p. 304-310. 18. Pineda, O., Ashmead, H.D., Effectiveness of treatment of irondeficiency anemia in infants and young children with ferrous bisglycinate chelate. Nutrition, 2001. 17: p. 381-84. 19. Adibi, A., Intestinal transport of dipetides in man: Relative importance of hydrolysis and intact absorption. J Clin Invest, 1971. 50: p. 2266-75. 20. Ashmead, H.D., Graff, D., Ashmead, H., Intestinal Absorption of Metal Ions and Chelates. 1985, Springfield, Illinois: Charles C. Thomas. 21. NNFA definition of mineral amino acid chlelates, in NNFA Today. 1996. p. 15. 22. Bioperine-Nature's Bioavailability Enhancing Thermonutrient. 1996, Sabinsa Corporation: Piscataway, N.J.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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FDA & Congress: Stop The Madness- Let the natural health revolution enhance our lives.
July 14, 2005 09:24 AM
FDA & Congress: Stop The Madness!Let the natural health revolution enhance our lives.
Here's a memo to the Food and Drug Administration and Congress: Enough is Enough. The American people are fed up with backroom politics. We are sick and tired of having our God-given right to natural health threatened by attempts to "protect" us from the very natural therapies that can help ensure our national health. You do not have the power to dictate or control our pursuit of natural health. First and foremost, end your attempts to regulate or even ban nutritional supplements! Americans choose to take supplements because we believe they contribute to optimal health and vitality. Who are the FDA and Congress to trample on our beliefs and pursuit of health and happiness?
Next, our enemies need to open their narrow minds to the sublime power of nature. We must embrace nature to evolve in body, mind and spirit. Our understanding of the healing power of natural elements has progressed significantly over the past century. We are on the cusp of a natural health revolution that will enhance the well-being of millions.
Natural supplements can change the world for the better. And yet, there the governments stands like an ignorant behemoth attempting to block our access to natural supplements. Step aside, we say. This is America, and we have the right to choose our own path to health.
Plant a seed and watch it grow. This is nature's most basic miracle. Part of this miracle is nature's inherent ability to create, perpetuate and enhance life. Science has proven that thousands of plants have healing powers, including powerful benefits for depression and pain management; that scientific knowledge affirms the wisdom employed by indigenous healers for centuries. These plants were placed on earth to comfort and relieve people suffering from painful, degenerative diseases of body and mind.
Who presumes to deny us nature? Look no further than to Congress and the FDA-for they are doing this right now. We must stop this behavior. The health and healing of all our people must take priority over all other interests.
Washington Update readers, rise up and unite! If the phiosophies in this column resonate with your own beliefs, then join the health freedom revolution! To uphold our freedom to take natural supplements, we must support like-minded souls and revolt against those working to rip our rights away.
Facing the right senators is an easy, effective way to help save supplements. Fax encouragement to key vitamin advocates, Senators Tom Harkin at 202-224-9369 and Orrin Hatch at 202-224-6331. Fax your disapproval to Senator Dick Durbin, a key figure in the movement to ban supplements, at 202-228-0400. Fax Senator Michael Enzy, Chairman of the Senate Subcommittee on Health, Education, Labor, and Pensions, at 202-228-0359. Tell Senator Enzi that you demand the freedom to take natural supplements. If you have already sent a letter or fax, please send another fax. Our health freedom depends on this fax campaign.
You can take action by visiting www.NHA2004.com and taking advantage of revolutionary technology that lets you rapidly and easily compose faxes to Congress. With your help, we can win the fight to keep safe, healthy supplements in our lives! For health, freedom, and liberty join NHA today!
The 50 Year Service Check...
July 07, 2005 09:18 AM
Sad but true: Guys who wouldnt forget to give their cars an oil change will go years without having their own inner workings inspected. But a reluctance to have ones chassis checked at the practitioner's office can translate into serious body engine failure. While physical exams are always important, they become a nevessity with advancing age. We're not saying 50 is old, mind you--a couple at Energy Times staffers are starting the big five-oh right in the face--but it's a good time to start getting regular checkups if you haven't been in the habit. Here's some of the things to look for next time they pop your hood.
Get those choppers checked at least once a year--untreated gum disease can lead to the kind of low-level inflammation now thought to be a culprit in numerous illnesses, including heart disease.
Some experts recommend yearly testing for glaucoma, a condition in which increased pressure within the eyeball can cause blindness if not treated. Presbyopia, the farsightedness that accompanies increasing age, generally starts in one's 40s; time to invest in a pair of reading glasses.
Have your blood pressure taken by a professional at least once a year. Checks for cholesterol and blood sugar are part of a metabolic panel (Standard blood work) to be done every three years; it should include total cholesterol, LDL "bad" cholesterol and triglycerides (blood fats). Discuss testing for CRP (C-reative Protein), a marker of chronic inflammation, with your practitioner.
The American Thyroid Association suggests an initial check of your thyroid, a gland in your neck that serves as the body's energy transformer, at age 35 with retests every five years afterwards. If you can't seem to lose weight and/or are sonstantly tired, ask about having your thyroid hormone levels assessed.
Your liver won't send out distress signals until it's pretty banged up. Since the standard metabolic panel includes the liver-enzyme check be sure to have it done every three years; that frequency may need to increase if you have a history of heavy alcohol or workplace exposure to toxins.
Having a yearly digital rectal examination (DRE) is recommended. Blood testing for prostate-specific antigen (PSA) is more contraversial.
Colonoscopy, in which a lighted tube is used to view the entire colon, is the gold standard (although doctors are working on a less invasive virtual colonoscopy); once every 10 years starting at age 50 is recommended. A fecal occult blood test (FOBT) should be preformed every year, but keep in mind it can yeild false results, positive and negative.
Don't Forget to:
Screening frequencies are for healthy individuals with no known risk factors. If you have a pre-existing condition or are at risk for one, follow your practitioner's recommendations.
: Energy Times
Quercetin and Bromelain - for better health.
July 04, 2005 10:28 AM
Down-regulates the Body’s Response to Environmental Challenges Quercetin is a member of the flavonoid family, a diverse group of low molecular-weight compounds found throughout the plant kingdom. Flavonoids exhibit numerous biological activities, many of which are directly beneficial to human health. Quercetin, which belongs to the “flavonol” subgroup, is one of the most versatile and important flavonoids. Quercetin has a broad range of activity, much of which stems from its interaction with calmodulin, a calcium-regulatory protein.1 Calmodulin transports calcium ions across cellular membranes, initiating numerous cellular processes. Quercetin appears to act as a calmodulin antagonist.1 Through this mechanism, quercetin functions at the cell-membrane level with a membrane-stabilizing action.2 Quercetin inhibits calmodulin-dependent enzymes present at cell membranes such as ATPases and phospholipase, thereby influencing membrane permeability.3 Quercetin affects other calmodulin-dependent enzymes that control various cellular functions, including the secretion of histamine from mast cells.4 A number of investigations have corroborated quercetin’s ability to reduce histamine secretion from mast cells in various tissues, and also from basophils.5,6,7,8,9,10
Quercetin modifies the body’s response to antigenic substances.* Suppression of histamine secretion from mast cells is one of quercetin’s most clinically important effects. Quercetin acts on ATPase at the membranes of histamine-containing granules in mast cells.3 Mast-cell degranulation and subsequent release of histamine into the bloodstream is an integral part of the body’s response to environmental challenges.
Quercetin’s enzyme-inhibiting action extends to enzymes such as phospholipase, which catalyzes the release of arachidonic acid from phospholipids stored in cell membranes.4,10 Arachidonic acid serves as the key substrate for substances such as thromboxanes, inflammatory prostaglandins and leukotrienes. In addition, quercetin inhibits the enzymes cyclooxygenase and lipoxygenase, which catalyze the conversion of arachidonic acid into its metabolites.4,10,11,12 Reducing levels of these metabolites, as well as histamine levels, is beneficial in maintaining the normal comfort level of body tissues and structures.
Quercetin has also been shown to limit the function of adhesion molecules on endothelial cells.13 Adhesion molecules are involved in physiologic processes that influence tissue comfort.13
Bromelain is a complex substance derived from the pineapple stem largely composed of proteolytic (protein-digesting) enzymes. Bromelain acts by a variety of mechanisms to help maintain tissues in a normal state of comfort.14,15 Several investigators, including Taussig16 and Ako, et. al.,17 have presented evidence that bromelain is a fibrinolytic agent, i.e., it induces the breakdown of fibrin, a plasma protein that blocks tissue drainage. The generally accepted mechanisms involve direct proteolysis of fibrin by bromelain and activation of plasmin, a serum protease.16 Plasmin acts on fibrinogen (the precursor to fibrin), forming peptides which stimulate PGE1, a prostaglandin that helps maintain tissue comfort.16
Helps Maintain Health of Blood Vessels by Modifying Oxidation of LDL Cholesterol* — Quercetin’s Antioxidant Action Quercetin is a versatile and effective antioxidant that scavenges a variety of free-radicals such as hydroxyl and lipid peroxy radicals.18 Quercetin also chelates ions of transition metals such as iron, which can initiate formation of oxygen free radicals.18 LDL cholesterol is vulnerable to oxidation by lipid peroxides. Oxidized LDL is absorbed by macrophages and arterial endothelial cells, leading to the formation of “foam cells,” and eventually plaque deposits, in arterial walls. Quercetin has been shown to protect LDL from oxidation, both by lipid peroxides and transition metal ions.19
Quercetin inhibits blood platelet aggregation (clumping), by potentiating PGI2, an anti-aggregatory prostaglandin, and by raising platelet cyclic AMP levels.20 Human studies have revealed that bromelain also reduces platelet aggregation.21 These properties qualify both quercetin and bromelain as valuable dietary ingredients for maintaining cardiovascular health.*
In addition to the actions described above that support the effects of quercetin, bromelain may also assist the absorption of quercetin in the G.I. tract. (Quercetin is generally believed to be poorly absorbed, although a recent study by Hollman et. al.,22 which concluded that humans do in fact absorb appreciable amounts of quercetin, contradicts this assumption.) Studies have shown that bromelain enhances absorption of antibiotics, presumably by increasing permeability of the gut wall.23, 24 Given that quercetin is a low molecular-weight compound, it is plausible that simultaneously ingested bromelain likewise enhances quercetin absorption.
The Management of PMS and Ginkgo
June 25, 2005 12:35 PM
The Management of PMS and Ginkgo
Symptoms of PMS usually include water retention, breast tenderness and vascular congestion. One hundred sixty-five women between the ages of 18 and 45 who suffered from significant PMS were tested with ginkgo, which was given from the 16th day of the first cycle to the 5th day of the next. Test studies confirmed that ginkgo was effective against various symptoms of PMS, particularly b reast changes. In addition, mental and emotional symptoms associated with PMS also decreased.15 Because Ginkgo is so safe to use, it may be very beneficial for women who have used drug therapy for PMS that had undesirable side effects.
Ginkgo: An Update
Ginkgo is currently being studied as a safer substitute for antirejection drugs which are routinely given to recipients of transplanted organs. Ginkgolide, the active component of ginkgo, somehow inhibits a chemical found in the body called PAF (platelet activating factor) which plays a role in organ rejection. It may also prove beneficial for congestive heart failure, angina, shock, multiple sclerosis and burns.
June 22, 2005 09:57 PM
Modified Citrus Pectin (MCP) and Mercury Cleansing Programs...
June 21, 2005 05:02 PM
by Isaac Eliaz, M.D., M.S., L.Ac.
Modified Citrus Pectin (MCP) is a dietary supplement derived from the peel and pulp of citrus fruit. MCP is mostly known for its positive effects on cellular health. Recently, however, clinical research on MCP has produced exciting results for its use as a gentle chelator (eliminator) of mercury and other heavy metals. Some of the expanding clinical applications for MCP include:
The Problem with Mercury
Recent news on mercury is particularly concerning for the U.S. population. In March 2004 the EPA issued a press release reporting nearly all fish contained traces of mercury. Some samples contained levels high enough to harm an unborn baby or young child's developing nervous system. These findings prompted the EPA to issue a warning to women who may become pregnant, pregnant women and nursing mothers advising them to eat only two meals of fish per week that are thought to have lower levels of mercury.1 In their most recent update (August 2004), the EPA issued a warning that 1/3 of the nation's lakes and 1/4 of its river ways are contaminated with toxic levels of mercury and other contaminants, and warned pregnant women and children against consumption of fish from these sources. Additionally, a National Academy of Sciences panel definitively warned that some children who had been exposed to mercury while in the wombs of their mothers were at risk for becoming those children "who have to struggle to keep up in school and who might require remedial classes of special education." The risk of mercury toxicity from fish has reached epidemic levels. Two studies have further spurred on the concerns of mercury toxicity, as they both found women to have mercury levels that are 8-10% above what is considered safe.1,2 Furthermore, women who ate more fish were found to have higher levels of mercury. Another source of mercury toxicity may be amalgam dental fillings. Heavy metals, in conjunction with the abundant presence of environmental toxins and xenoestrogens, constitute a dangerous insult to the body through DNA damage, hormonal modulation, immune suppression, oxidative stress, and cellular irritation.
A New Application for MCP Use: Heavy Metal Detoxification
The standard western medical approach for removing mercury from the body to treat mercury toxicity is chelation. This procedure is performed with harsh chelators that can cause multiple side effects while potentially robbing the body of some of its essential nutrients. While this may be the routine and most beneficial procedure when facing a serious toxicity problem, are there other, gentler ways to reduce mercury levels? Two recent clinical studies have found that MCP may be a promising new dietary solution for reducing heavy metal load. In one recent clinical study, MCP was administered to a group of volunteers, and baseline levels of their total body mercury burden were measured and then compared against levels after treatment with MCP (15 grams of PectaSol® daily) for four months. The results showed a significant average decrease (over 60%; p=0.03) in the total body mercury burden after treatment with MCP3 In an earlier study, PectaSol® was given to patients and proven to increase urinary secretion of heavy metals such as lead, mercury, cadmium and arsenic.4 Both studies concluded that MCP may be a promising alternative to the harsher intravenous chelating therapies as MCP was found to be both effective and free of any side effects.
How MCP Works as a Gentle Chelator
Pectins are natural gelling agents, binders, thickeners, and stabilizers in foods. They mostly consist of galacturonic acid and galacturonic-acid methyl esters with average molecular weights from 50,000 to 150,000 daltons. High-methoxy (HM) pectin has at least 50% DE (degree of esterification) or greater, while a low-methoxy (LM) pectin?s DE is 50% or less. For systemic chelation of heavy metals, pectin is modified to a low molecular weight, and low-methoxy content. My observation from using MCP as a detoxification agent in my clinic is that it works as a gentle chelator in the bloodstream and it is very useful for ongoing use. Because fish are still recommended as part of a healthy diet and an essential source of certain nutrients (essential fatty acids like DHA), mercury levels are also becoming a widespread health concern. It is a Catch-22 for dietary health. As the widespread environmental cleanup of mercury is unlikely in the short-term, the medical community should develop methods to treat toxicity or reduce high body levels of mercury body burden. One approach is the use of traditional and alternative medicine cleansing programs along with the use of dietary supplements such as MCP that may act as gentle chelators. For chelation purposes, 5-15 grams of MCP should be taken per day depending on mercury levels for one year. Maintenance at 2-5 grams per day thereafter is usually sufficient. In my practice, I use 15 grams per day or 15 grams per day in the first 3-5 days of the month and 5 grams per day for the remainder of the month. MCP is generally regarded as safe and is well tolerated. Reported side effects have been rare, but may include mild and transient gastrointestinal discomfort.
1-CDC Press Release: Blood and Hair Mercury Levels in Young Children and Women of Childbearing Age-United States, 1999 (see:/media/mmwrnews/n010302.htm#mmwr3) 2-Schober, SE, Sinks, TH, Jones, RL et al. (2003) Blood mercury levels in US children and women of childbearing age, 1999-2000. Journal of the American Medical Association. 289(13) :1667-74. 3-Eliaz, I. (2004) Modified citrus pectin (MCP) in the treatment of cancer. Paper presented at: The American Chemical Society Annual Meeting; Philadelphia, PA. 4-Eliaz, I. and D. Rode (2003). The effect of modified citrus pectin on the urinary excretion of toxic elements. Fifth Annual Conference of Environmental Health Scientists: Nutritional Toxicology and Metabolomics, University of California, Davis.
Isaac Eliaz, M.D., M.S., L.Ac., is a pioneer in the field of integrative medicine and founder of Better Health Publishing®, an education-based company that provides health care professionals, consumers and other interested parties with scientific research on integrative medicine. He is a respected author, clinical practitioner and frequent guest lecturer on integrative medical approaches to health, immune enhancement and cancer prevention and treatment. Since 1991, Dr. Eliaz has maintained a busy private practice in Sebastopol, California, and is the current medical director of the Amitabha Medical Clinic and Healing Center (email:firstname.lastname@example.org) which focuses primarily on integrative and holistic protocols for cancer patients as well as those with chronic health challenges.
Health Movements - Joining mind and body with healthy movement generates harmony
June 12, 2005 05:49 PM
Health Movements by Sylvia Whitefeather Energy Times, December 6, 2003
Mind/body exercises like yoga (especially the super-popular Bikram variety), tai chi and Pilates aren't just trendy, they're custom made to soothe the rough edges of modern life. So often does today's fast-paced world emphasize the mental and competitive aspects of existence that its inhabitants frequently neglect the necessity of gentle movement for the body. But these exercises are an antidote to the tendency to view the mind and body as separate entities.
Modern science is validating what traditional teachers have always known: The mind dwells in every cell. Joining mind and body with healthy movement generates harmony, lowers your chance of chronic illness and promotes emotional stability.
No one knows when yoga first appeared. Historians and archaeologists figure the practice was initiated in India somewhere between 3,000 and 1,500 BCE. But the father of the modern forms of yoga is considered to be a man named Patanjali, who wrote the Yoga Sutra around 200 CE.
The literal translation of the word yoga is "union." As Jennifer Schwamm Willis notes in her book The Joy of Yoga (Marlowe), this practice represents "the union of body, mind and spirit." The purpose of learning the fundamental movements of yoga is to connect with your body, release knots of tension and improve strength and flexibility. In that way, the physical balance during a yoga session translates into inner balance during times of crisis or distress. Schwamm points out that ancient yoga practitioners believed "the aim of yoga is to quiet the fluctuations of the mind, to create stillness in order to hear one's inner voice..."
Yoga is used by many for stress relief. But it has other important uses: In a study presented by Oregon Health & Science University at the American Academy of Neurology meeting in April 2003, yoga was shown to benefit folks with multiple sclerosis. The researchers found that participants who regularly attended yoga class for six months suffered less fatigue and improved their quality of life.
A yoga class generally begins with warm-up postures, moves on to a core group of basic postures, and ends with poses meant to cool you down. An important aspect of yoga is breath work and control. Movement in and out of poses involves carefully orchestrated breath work. Inhalation and exhalation in timed sync with movement lies at the heart of yoga's benefits. Yoga beginners often feel stiff and inflexible. But with gentle, patient, regular practice, greater flexibility, strength and balance can be had. Experts say that a yoga session does not demand struggle; it asks for surrender. If one pose causes discomfort, try another.
One particular form of yoga, Bikram, is hot in terms of both popularity and room temperature: Not only is it one of the biggest trends in the fitness world, this demanding, aerobic take on yoga is conducted in heated rooms designed to maximize muscle relaxation and minimize injury risk. The heat also helps facilitate cleansing and detoxification. It was created by Bikram Choudhury, a four-time Indian yoga champ who founded the Yoga College of India in Beverly Hills, California.
As in other types of yoga, Bikram uses asanas, or poses, handed down through generations of yoga teachers. In this case, though, 26 asanas are done in a prescribed order over a 90-minute period. Everyone, from novice to expert, works out together, the idea being that each individual is working to stretch his or her own limits by becoming stronger, more flexible and less prone to illness.
Bikram yoga stresses the tourniquet effect, in which blood floods through vessels after they've momentarily been squeezed shut. This pressurizing effect is supposed to flush out debris, quickening circulation and releasing stress. The tourniquet effect also helps cleanse the lymphatic system. Proponents say Bikram improves balance, concentration and posture; increases energy; and eases sleep.
Like any other exercise program, Bikram yoga requires diligence: one center says a minimum of 10 classes over 30 days is needed for maximum benefits. And while hydration is important during all fitness routines, consuming adequate water is crucial when you're exercising in a hot room.
Tai chi (also known as taiji or tai chi ch'uan) consists of a series of fluid movements that build endurance, increase flexibility and balance, and foster alertness of mind and spirit. Tai chi developed around the 13th century as a form of martial arts in China based on the power of flow and grace, rooting and yielding, flexibility and endurance. To the onlooker, a person practicing the movements of tai chi has the quality of someone swimming in air.
This gentle form of movement can be practiced by people of almost all ages and physical conditions. Tai chi does not require special equipment, props or a floor mat. As a non-impact form of exercise, tai chi delivers minimal stress to the joints. Tai chi emphasizes proper body alignment and uses the large muscles in the legs to relieve stress from the hips, back and shoulders. It strengthens joints, increases range of motion and improves circulation of all body fluids. Like many other forms of mind/body exercise, tai chi relieves stress.
Tricia Yu, author of Tai Chi: Mind and Body (DK), has been practicing tai chi for over 30 years. She believes that tai chi not only has benefits as a health exercise, but that it "can have a beneficial effect on your mental and emotional states, as well as help you to feel connected with your surroundings." Yu adds, "Like yoga, tai chi originated in a culture that views the mind and body not as separate but rather as different expressions or states of qi-vital energy or life force."
Current research has validated the health benefits of tai chi. One study found that the knee strength of elderly people practicing tai chi improves significantly (J Gerontol A Biol Med Sci 2003 August; 58:M763-6). Participants in this study, whose average age was 72 years, benefited significantly after five months of tai chi. For the elderly, this extra strength and control translates into fewer falls and injuries.
Tai chi may help immunity. In a study published in the September 2003 issue of Psychosomatic Medicine, researchers reported that elderly folks who participated in a tai chi class for a period of 15 weeks "saw an improvement in factors that suppress shingles [a painful viral condition] increase by 50%." They also showed an increased ability to move throughout the day and a significant improvement in their general health.
Joseph Pilates (1880-1968) was a sickly child afflicted with asthma, rickets and rheumatic fever. Determined to recover his health, Pilates studied both Eastern and Western forms of exercise, incorporating moves from gymnastics, yoga and wrestling, along with controlled breathing. With his wife, Clara, Joseph Pilates developed the form of exercise known today as simply Pilates. In the 1920s, Joseph left his native Germany and came to New York City and began teaching his exercise style in dance studios.
Today, Pilates has gained acceptance both as an exercise style for fitness and as a system for physical rehabilitation. Because of its benefits, Pilates is practiced in hospitals, wellness centers, gyms and specialized Pilates studios. It is used by athletes, dancers and anyone looking to increase endurance and improve flexibility, balance and muscle tone.
The basic principle of Pilates focuses on increasing what is called core strength. Core muscle groups include the abdominal, pelvic floor and back muscles. If these muscle groups are strong, then the body is balanced and strong. The Pilates method also encourages flexibility by building long, strong muscles without bulk.
The Stott method is one of the most popular forms of Pilates. This technique combines traditional Pilates exercises with movements updated to conform with modern knowledge about the biomechanics of the human body. By stabilizing muscles in the pelvis and shoulders, and keeping the spine and pelvis in safe, neutral positions, knowledgeable Pilates instructors minimize the chance of injury during these exercises.
Pilates exercises have been shown to help reduce back pain. Researchers report that "Pilates method can be useful for patients with chronic low back pain and deconditioning" (J Manipulative Physiol Ther 2002 May; 25/4:E3).
According to Ken Endelman, the founder of Balanced Body, maker of Pilates equipment, "Pilates is a full-body exercise. It focuses on flexibility and control, not adding bulk; bulk defeats flexibility. This flexibility is particularly important as we age. Staying flexible is key, and Pilates is good at those types of things."
A Pilates routine can be structured to fit your specific physical needs or goals. Instructors use specially designed equipment along with mat work to improve fitness. The human body was designed to move. Again and again, research shows that exercise maintains health, vitality, longevity, weight and quality of life. If you match your exercise with your physical needs and goals, and your personality, you are more likely to stay with that program whether it is aerobics, walking, Pilates or yoga. For real benefits, physical fitness has to be a lifetime endeavor.
June 10, 2005 09:44 PM
Breast Cancer by Joseph L. Mayo,MD Mary Ann Mayo, MA Energy Times, May 2, 1999
What do you fear most? Bankruptcy? Floods? Heart disease? If you're like many women, breast cancer stands near the top of that dreaded list.
But that fear doesn't permeate other cultures the way it does ours.
A woman like Mariko Mori, for instance, 52 years old, Japanese, worries about intense pressures beginning to burden her toddler grandson. But worry about breast cancer? Hardly.
In Indiana, Mary Lou Marks, 50, has similar family frets, mulling over her 28-year-old daughter's career choice.
But on top of that, when Mary Lou tabulates her other worries, she recoils at the thought of breast cancer. She's heard about her lifetime risk: 1 in 8. Meanwhile, Mariko's is merely 1 in 40, according to Bob Arnot's Breast Cancer Prevention Diet (Little, Brown).
New studies have found the effect of carrying the gene linked to breast cancer, which is responsible for only 5 to 10% of breast cancer incidence, is not as great as first suspected. Earlier estimates that the gene reflects an 80% chance of incurring breast cancer by age 70 has been recalculated to be only 37% (The Lancet, 1998;352:1337-1339).
Complex Causesbr> Researchers agree: No one factor is solely responsible for breast cancer. Risk depends on many factors, including diet, weight, smoking, alcohol consumption, activity level and, of course, those genes.
Regardless of their actual chance of getting breast cancer, women worry. Mary Lou faces no factors that would place her in particular jeopardy. But her anxieties about radical therapies and medical expenses paralyze her: She forgets to visit her health care provider and skips her annual mammogram appointments. Mary Lou's daughter, perhaps in reaction to her mother's gripping fears, campaigns ardently for cancer prevention, educating herself and mobilizing against the cumulative effects of known cancer risks. Smart young woman: A malignancy, after all, can take years to develop. A tumor must swell to one billion cells before it is detectable by a mammogram.
The soy-rich regimen of Japanese women like Mariko Mori, for example, helps to explain the low breast cancer rates in Asian countries (see box at center of the page).
Tomatoes, because of their high quotient of the carotenoid lycopene, have been found to protect cells from the corrosive clutches of oxidants that have been linked with cancer in 57 out of 72 studies (The Santa Rosa Press Democrat, February 17, 1999, page A6, reporting on a Harvard Medical School study). For more on tomatoes see page 16.
But there's no one magic anti-cancer food or diet. Eating to prevent breast cancer requires a balanced menu with fiber, healthy fats, phytoestrogens and antioxidants, all fresh and free of chemical additives.
Modifying the balance and type of estrogen, the female sex hormone produced by the ovaries, offers an important breast cancer safeguard. Fat cells, adrenal glands and, before menopause, the ovaries, produce three "flavors" of estrogen, the strongest of which, estradiol, is believed to be carcinogenic when too plentiful or persistent in the body.
Estrogen does its work by attaching to estrogen receptors. Receptors are particularly numerous in the epithelial cells that line milk sacs and ducts in the breasts.
A receptor site is like a designated parking spot: Once estrogen is parked there it triggers one of its 400 functions in the body, from preparation of the uterus for pregnancy to intensifying nerve synapses in the brain.
The food we eat can be a source of estrogen; plant estrogens, called phytoestrogens, are much weaker than the body's estrogens, but they fit the same receptors. Phytoestrogens exert a milder estrogenic effect than bodily estrogen and are capable of blocking the more potent, damaging versions.
Soy also contains genistein, an "isoflavone" very similar in molecular form to estrogen but only 1/100,000 as potent. Because of its structure, genistein can attach to cells just as estrogen does; it also helps build carriers needed for binding estrogen and removing it from the body (Journal of Nutrition 125, no.3 :757S-770S). It acts as an antioxidant to counteract free radicals.
Soy is most protective for younger women. Postmenopausal women benefit from soy's ability to diminish hot flashes and for cardiovascular protection, especially in combination with vitamin E, fiber and carotene (Contemporary OB/GYN, September 1998, p57-58).
Experts don't know that much about the cumulative effect of combining hormone replacement with soy, herbs and a diet high in phytoestrogens. Menopausal women who boost their estrogen this way should work with their health care providers and monitor their hormonal levels every six to 12 months with salivary testing.
The Vegetable Cart
Fiber from fruits, vegetables and whole grains reduces insulin levels and suppresses the appetite by making make us feel full, thus helping with weight control, so important to resisting cancer. Fiber also helps build estrogen carriers that keep unbound estrogen from being recirculated and reattached to the breast receptors.
Cellulose, the fruit and vegetable fiber most binding with estrogen, also rounds up free radicals that damage DNA within cells.,p> Feeding the Immune System Despite heightened public awareness and efforts to stick to wholesome, healthful diets, experts increasingly link poor nutrition to depressed immune systems. Many Americans are at least marginally deficient in trace elements and vitamins despite their best attempts to eat well; that's why a good multivitamin/mineral is wise, even mandatory. Vitamins given to people undergoing cancer treatment stimulate greater response, fewer side effects, and increased survival (International Journal of Integrative Medicine, vol. 1, no. 1, January/February 1999).
Nutrients tend to work synergistically on the immune system. They should be taken in balanced proportions, and in consultation with your health care provider.
n Riboflavin (B2), pyridoxine (B6), pantothenic acid (B5), zinc and folate strengthen immunity. Selenium, in lab culture and animal studies, has helped kill tumors and protect normal tissues.
n Beta-carotene and vitamins A, E and C are antioxidants. Vitamin C enhances vitamin E's effects, boosting immunity and protecting against cell damage. The antioxidant isoflavones in green tea, with soy, convey the anticancer effects of the Asian diet. Research shows actions that discourage tumors and gene mutations.
The food you eat influences hormones. Excess sugar raises insulin, which acts as a growth factor for cancer and interferes with vitamin C's stimulation of white blood cells. It may contribute to obesity.
Alcohol is converted to acetaldehyde, which causes cancer in laboratory animals. It affects gene regulation by decreasing the body's ability to use folic acid. It increases estrogen and the amount of free estradiol in the blood. The liver damage that accompanies high alcohol consumption frequently reduces its capacity to filter carcinogenic products, regulate hormones and break down estrogen. Studies of alcohol consumption have caused experts to estimate that drinking more than two alcoholic beverages a day increases breast cancer risk by 63% (OB-GYN News, November 1, 1998, p. 12).
Fat Can be Phat
Fat cells produce estrogen. Excess fat stores carcinogens and limits carriers that can move estrogen out of your system.
Once estrogen has attached itself to a receptor, the health result depends on the type of fat in the breast. Saturated fat, transfatty acids and omega-6 fat from polyunsaturated vegetable oils such as safflower oil, peanut, soybean oil, corn oil and in margarine can increase the estrogen effect and trigger a powerful signal to the breast cell to replicate.
Breast tissue is protected by omega-3 fat chiefly from fish and flaxseed and by omega-9 from olive oil. Salmon once a week or water packed tuna three times a week are particularly beneficial. Fish oil supplements processed to reduce contaminates are available. Cod liver oil isn't recommended: its vitamin A and D levels are too high.
Flaxseed is the richest known plant source of omega-3. Use a coffee grinder to benefit from the seed and oil for the full estrogen effect; sprinkle ground flaxseed over cereal or fold into baked goods. Drizzle flaxseed oil, found in the refrigerator section of your health food store, over salads or cereal. (Store the oil in the refrigerator.)
Olive oil, especially in the context of the so-called Mediterranean diet of vegetables, omega-3-rich fish and fresh fruit (Menopause Management, January-February 1999, p. 16-19), lowers the risk of breast cancer (The Lancet, May 18, 1996;347:1351-1356).
Selecting Organic Food
Buy or grow fresh, organic foods whenever you can. When grilling meat, fish or poultry, reduce the area where carcinogens may accumulate by trimming fat. Charred, well-done meat is known to be carcinogenic. When grilling, marinate meat first and reduce the cooking time on the grill by slightly precooking.
Cancer prevention is an interlocking puzzle requiring the limitation of fat consumption, weight control, exercise, stress reduction and care for psychological and spiritual balance. Possessing more cancer fighting pieces makes you more likely to be able to complete the prevention picture.
Joseph L. Mayo, MD, FACOG and Mary Ann Mayo, MA, are the authors of The Menopause manager: A Safe Path for a Natural Change, an individualized program for managing menopause. The book's advice, in easy-to-understand portions, isolates in-depth explanations with unbiased reviews of conventional and alternative choices. A unique perspective for mid-life women who want to know all their options.
Also from the Mayos - The HOW Health Opportunities For Women quarterly newsletter to help women learn HOW to make informed health choices. Learn HOW to: - Choose nutritional supplements
Largest Human Clinical Study Confirms Aged Garlic Extract's Ability to Reduce Cancer Risk
June 09, 2005 05:26 PM
Largest Human Clinical Study Confirms Aged Garlic Extract's Ability to Reduce Cancer Risk Factors Presented at the 2005 World Garlic Symposium at Georgetown
Garlic has been used medicinally for thousands of years. Past research has established the significance of garlic and its healthful benefits. Recently new metabolic roles for garlic were presented at the symposium, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease” which was held at the Georgetown University Conference Center on April 9-11, 2005.
The conference brought together the world’s top authorities in various fields of garlic research to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states such as cancer.
One of the highlight presentations was on the biggest study ever conducted in the history of garlic supplementation, a 7 year long clinical study. The study was undertaken to determine aged garlic extract effects on stomach cancer and serous digestive problems that can lead to gastric cancers. It was performed through collaboration of National Cancer Institute (NCI) and leading Chinese researchers, who tested to see if aged garlic supplementation would significantly effect or reduce precancerous gastric lesions. The clinical study was double-blinded and randomized, with over 3,000 human subjects. It was led by Dr. Mitchell Gail at NCI and Dr. Wei-Cheng You at the Beijing Institute for Cancer Research.
Preliminary results of this study showed that people with the highest intake of allium-containing vegetables, like aged garlic, had only 40% of the risk of gastric cancers as those who rarely ate them.
Also from the Chinese study was another surprising finding: when researchers used aged garlic extract in combination with antibiotics to treat people with precancerous stomach lesions caused by the Helicobacter pylori bacteria, 76% were completely healed. “It’s a very large and long-term study. We’re still sifting though the data, but we expect to report on it by the end of this year,” said Dr. Gail.
Another surprising presentation showed the results of several colon cancer studies reported from both Osaka and Hiroshima University in Japan. These studies clearly showed that the addition of aged garlic extract to cancer treatment was beneficial to colon cancer patients. Researchers found that those who consumed aged garlic extract experienced a reduction of the size and prevalence of tumors.
“Aged garlic extract has well-known antioxidant properties. The aging process eliminates garlic breath as well as those harmful properties, leaving only the antioxidants that protect against disease,” said cancer symposium chairperson and lead UCLA researcher David Heber, M.D.
Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects.
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease
June 09, 2005 05:22 PM
The Latest Breakthroughs in Garlic Research
on Cancer and Cardiovascular Disease
Presented at the 2005 World Garlic Symposium
Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005.
“For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.”
Presentation highlights included:
Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.
“Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.”
Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. .
PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892
Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders.
INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA
Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events.
INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany
Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.
David Heber, MD, PhD, FACP, FACN
Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center
Matthew Budoff, MD, FACC
Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.
GlucosaMend™ Tissue/Joint Repair Complex
June 02, 2005 11:19 AM
More than 40 million Americans experience joint discomfort. But exciting new research proves you can do something about it. Our health and well-being is inextricably linked to lifestyle choices: the right combination of exercise, weight training and supplementation can strengthen muscles and joint tissues to minimize stress and degradation. Targeted nutrition to the multiple body systems related to joint and connective tissue can help maintain flexibility and joint comfort. GLUCOSAMEND supports the musculoskeletal system with structural building blocks and tissue production cofactors, as well as aiding the body’s mechanisms for soothing relief and antioxidant defense.
Bio-Aligned Formula™ GLUCOSAMEND is uniquely effective because it is a Bio-Aligned Formula. Source Naturals evaluates the underlying causes of system imbalances. Then we design formulas that provide targeted nutrition to bring your interrelated body systems back into balance.
Musculoskeletal System—Structural Building Blocks
Certain building blocks of joints and connective tissue can help maintain joint integrity and comfort. Glucosamine is a major constituent of glycosaminoglycans, which in turn form proteoglycans, molecules that hold and bind the water that lubricates joints, disperses stress and nourishes joint tissue. The amino acids proline and lysine are structural components of collagen and elastin, which give strength to connective tissue. GLUCOSAMEND contains glucosamine sulfate, N-acetyl glucosamine, proline and lysine.
Musculoskeletal System—Tissue Production Cofactors
Some micronutrients are necessary as cofactors in the production of connective tissue. For example, vitamin C and copper help form hydroxyproline and hydroxylysine, main constituents of collagen. A unique property of grape seed extract is its ability to form a bond between broken collagen fibers, helping to repair them and restore flexibility and strength to connective tissues and joints. GLUCOSAMEND provides vitamin C, zinc, manganese, copper, and grape seed extract to address these cofactors.
Soothing Relief Mechanisms
Some herbs and nutrients have the capacity to support the body’s natural mechanisms for increasing comfort. Boswellia, for example, is an herb with soothing properties, while vitamin B-6 helps to stabilize collagen and elastin. Additional herbs and nutrients, acting in conjunction with antioxidant protectors, support tissue comfort and health. GLUCOSAMEND contains Boswellia serrata, quercetin, copper, and vitamin B-6.
The health and integrity of joints and tissues—specifically of cell membranes— is supported by botanicals and nutrients that support the body’s natural antioxidant response. When tissues become damaged, the body mounts a repair process that ultimately generates free radicals. These free radicals can also break down healthy cells and tissues in the process, hence the need for antioxidants to neutralize and break the cycle. GLUCOSAMEND provides grape seed extract, vitamin C, zinc, selenium, copper, quercetin to neutralize free radicals.
Lifestyle Tips for Healthy Joints: A Strategy for WellnessSM
Healthy lifestyle habits should be part of your individual strategy for joint wellness. Source Naturals believes in a holistic approach to living. Not only can supplements bring balances to your individual body systems but certain lifestyle choices can also bio-align your health. Exercise Regularly: Regular physical activity helps lubricate cartilage, strengthens muscles around joints, and promotes weight control. An exercise program geared to joint health includes stretching, mild weight training, and low-impact aerobics. Watch Your Weight: Population-based studies, including the well-known Framingham study, have consistently shown a link between obesity and challenges to joint health. Excess weight causes pressure on joints, and can speed the rate at which cartilage wears down. Eat Healthy: To support healthy joints, increase your intake of omega-3 fatty acids from salmon, sardines, flax seeds or flax oil, avoid excess protein intake, and replace animal with plant proteins when possible. You should also eat lots of organically grown fruits and vegetables, limit saturated fat and eliminate hydrogenated oils. Rest and Relaxation: Regularly scheduled rest gives your body time to recover and rebuild, allowing you to make the most of your exercise program. It’s important to know when to slow down. Supplementation: Source Naturals offers a range of products that can supplement your strategy for joint wellness. These include the pineapple enzyme BROMELAIN; SAME, a natural compound formed from the amino acid methionine, which has been found to support joint comfort and mobility; and CHONDROITIN to promote water retention and elasticity in cartilage and inhibit enzymes that break down cartilage.
Structural Building Blocks N-Acetyl Glucosamine, Glucosamine Sulfate, L-Lysine, L-Proline Tissue Production Cofactors Grape Seed, Copper, Manganese, Zinc, Vitamins A, B-6 and C, Niacinamide Soothing Relief Mechanisms Boswellia Serrata, Quercetin, Turmeric, Copper, Magnesium, Zinc, Vitamin C Antioxidant Defense Grape Seed, Quercetin, Manganese, Selenium, Zinc, Vitamins A, C and E
Tonalin CLA and Diet Tonalin CLA - May Help Loose Weight ...
June 01, 2005 12:45 PM
Dramatic new research has identified a fatty acid that may positively influence body composition. Conjugated Linoleic Acid (CLA), found mainly in meat and dairy products, used to be abundant in our diets. But with the trend to lower fat diets, our CLA intake also is declining. It is an irony that so many Americans seem to be getting fatter, even as we eat less fatty foods. Researchers at the University of Wisconsin may have found an explanation for this paradox. Their studies suggest CLA may be an important nutrient for optimal body composition, possibly helping to reduce body fat and increase muscle. Aware consumers are unlikely to go back to the unhealthy, meat-laden diets of the past. But today CLA is available from pure sunflower oil. Introducing: Source Naturals TONALIN CLA.
Research Uncovers an Unrecognized Fatty Acid
CLA is a term referring to a group of derivatives of the essential fatty acid, linoleic acid. CLA, a polyunsaturated fatty acid, is found naturally in certain foods, especially meat and dairy products. CLA has been known for more than 18 years, but studies of its relationship to body composition are more recent. Studies now suggest that CLA may positively influence our bodies’ efficiency in using food, and have a beneficial effect on the balance between fat and muscle in our bodies. Clinical trials are now underway to explore the mechanism by which CLA works, and to determine whether the results of these laboratory and animal tests are also applicable to humans.
CLA may have a number of other benefits for our bodily systems. In fact, the University of Wisconsin researchers first discovered CLA’s role in influencing body composition as a result of research they were carrying out on CLA’s other properties. Among other important functions, CLA may be beneficial for our cardiovascular system due to its role in helping maintain normal cholesterol levels.
CLA: Insufficient in Today’s Diet
CLA used to be abundant in our diets. Today, however, Americans are eating less beef and full-fat dairy products. This translates to lower levels of CLA in our diets. CLA content is also much lower than it used to be in beef. Researchers believe this may be related to changes in the way cattle are fed. The green grass eaten by grazing cows is rich in polyunsaturated fatty acids including linoleic acid. Cows have a unique digestive system that converts linoleic acid to CLA - a close chemical relative of linoleic acid. The CLA is then stored in the cows’ tissues. It is possible that, since cattle today are predominantly fed oats, barley and hay rather than grazing on grass, they are no longer producing as much CLA.
A Plant-Based Alternative
Now, with Source Naturals TONALIN™ CLA, you can derive the benefits of CLA without consuming large amounts of animal fat. TONALIN CLA is manufactured by a proprietary process from sunflower oil. Source Naturals TONALIN CLA is available in 1000 mg softgels, consisting of 600 mg of CLA standardized to contain 40% cis-9-trans-11-octadecadienoic acid, one of CLA’s most important constituents. Three softgels - the suggested daily use - provide approximately the same amount of CLA as eating five pounds of beef, or 45 one-ounce slices of processed American cheese, or almost a gallon of ice cream every day! Source Naturals TONALIN™ CLA is available in 30, 60 and 120-capsule bottles.
Cranberry (Vaccinium macrocarpon)
May 19, 2005 10:34 AM
VitaNet ® Staff