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NSAIDs vs. Curcumin: Which One Relieves Joint Pain Without Stopping Healing?   
Date:
September 14, 2026 11:22 AM
Comparative Analysis of NSAIDs versus Curcumin in Musculoskeletal Tissue RepairPrimary Biological Mechanisms and Pharmacological TargetsManaging soft tissue and joint injuries presents a persistent therapeutic challenge in musculoskeletal medicine. Acute inflammation triggers pain, localized swelling, and mechanical disability, which routinely drives patients toward pharmacological relief. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, celecoxib, and diclofenac have served as primary clinical interventions. While these synthetic agents effectively extinguish acute pain signals, expanding cellular and clinical research indicates that their biochemical mechanism interrupts the fundamental repair cascades required for long-term connective tissue healing. In contrast, curcumin - a natural polyphenolic compound derived from the rhizomes of Curcuma longa (turmeric) - exhibits a distinct, multi-targeted regulatory profile that calms hyperactive inflammation while protecting the structural components of cartilage and tendon tissue.The functional divergence between these two compounds becomes clear when considering an intuitive mechanical analogy. Tissue trauma resembles damage to a commercial building, where initial inflammation functions as the construction and demolition crew tasked with clearing rubble, stabilizing the foundation, and laying down fresh structural framing. NSAIDs function like abruptly cutting electrical power to the entire work site: the noisy machinery stops instantly and the immediate disturbance ceases, but the construction workers lose the power necessary to clean the debris and erect permanent walls. Conversely, curcumin operates as an experienced site manager: it silences unnecessary chaos and prevents site vandalism while ensuring that the skilled workers - specifically chondrocytes in cartilage and tenocytes in tendons - remain fully active, supplied, and capable of completing the restoration. At the cellular level, NSAIDs exert their effects through the catalytic inhibition of cyclooxygenase enzymes, categorized as constitutive cyclooxygenase-1 (COX-1) and inducible cyclooxygenase-2 (COX-2). Membrane phospholipids damaged during injury release arachidonic acid, which COX enzymes convert into pro-inflammatory lipid mediators known as prostanoids, most notably prostaglandin E2 (PGE2). Nonselective NSAIDs block both isoforms, while selective coxibs specifically target COX-2. By shutting off PGE2 production, NSAIDs rapidly elevate pain thresholds and blunt localized swelling. However, because PGE2 also functions as a vital signaling cue for cellular recruitment, angiogenesis, and cellular proliferation, this total enzymatic shutdown strips local repair cells of the baseline signals required to orchestrate tissue regeneration. Curcumin avoids this indiscriminate pathway paralysis by acting upstream on master transcriptional control switches rather than directly neutralizing isolated enzymes. Its primary therapeutic mechanism centers on the inhibition of Nuclear Factor-kappa B (NF-kB) and Activator Protein-1 (AP-1) signaling networks. Under acute stress or chronic inflammatory loads, the NF-kB protein complex is released from its cytoplasmic inhibitor, IkBa, and translocates directly into the cell nucleus, where it drives the transcription of catabolic cytokines such as interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-a), and interleukin-6 (IL-6). Curcumin blocks the phosphorylation and degradation of IkBa, effectively keeping NF-kB trapped in the cytoplasm. By preventing this nuclear entry, curcumin attenuates the expression of pro-inflammatory cytokines and downstream matrix-degrading enzymes while preserving baseline physiological functions. Furthermore, curcumin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) pathways, which upregulate endogenous cellular antioxidants to neutralize destructive reactive oxygen species (ROS) that induce cell death in injured joints.
The Mechanisms of NSAID-Induced Inhibition in Cartilage and Tendon RepairArticular cartilage and tendons are specialized, bradytrophic connective tissues characterized by relatively low basal metabolic rates and limited endogenous vascular supplies. These physical constraints make their cellular maintenance highly vulnerable to pharmaceutical disruptions. When synthetic compounds impair cell migration, survival, or extracellular matrix secretion, the intrinsic repair capacity of these structures is substantially degraded.Cartilage maintenance depends on chondrocytes, the sole cell type residing within articular joints, which are responsible for generating and maintaining the extracellular matrix of Type II collagen and water-binding proteoglycans such as aggrecan. Because adult articular cartilage lacks a direct vascular network, major defect repair relies heavily on the recruitment and chondrogenic differentiation of subchondral mesenchymal stem cells (MSCs) through endochondral ossification. Experimental evaluations demonstrate that systemic or intra-articular NSAID exposure halts this regenerative differentiation. Both nonselective NSAIDs and selective COX-2 inhibitors interfere with chondrocyte maturation and prevent successful tissue integration following cartilage transplantation or microfracture procedures. At the cellular level, common NSAIDs - including indomethacin, ketorolac, and diclofenac - induce cell cycle arrest in chondrocytes by blocking transition from the resting G0 phase to the proliferative G1. phase, substantially reducing viable cell numbers. Concurrently, NSAIDs downregulate Bone Morphogenetic Protein-2 (BMP-2), an essential anabolic signaling molecule that orchestrates matrix synthesis. Histological analyses in animal models reveal that NSAID administration causes a marked loss of extracellular proteoglycan content and widespread chondrocyte depletion, yielding elevated modified Mankin scores that signify advanced structural degeneration. In layman's terms, proteoglycans serve as water-absorbing structural sponges that grant cartilage its elastic shock absorption. When NSAIDs deplete these molecules, the joint surface dries out, becomes brittle, and rapidly wears down under routine mechanical friction. Tendon healing is similarly susceptible to disruption by NSAIDs. Tendons operate as high-tensile structural cables composed of longitudinally arranged Type I collagen fibers, maintained by specialized fibroblasts termed tenocytes and tenoblasts. Healing after acute rupture or chronic tear progresses through an initial inflammatory phase, followed by a proliferative phase of cell migration, and culminates in a lengthy remodeling phase of collagen alignment. In vitro and in vivo studies establish that NSAIDs directly suppress the migration and proliferative capacity of tenocytes during the critical early healing window. Without an adequate cellular workforce migrating into the wound bed, provisional collagen scaffolding cannot be synthesized effectively. The disruption is particularly pronounced at the enthesis, the specialized fibrocartilaginous junction where soft tendon inserts into rigid bone. Re-establishing this transition zone requires coordinated bone remodeling and chondrogenic differentiation, both of which are hindered by COX inhibition. In animal rotator cuff repair models, early administration of NSAIDs significantly delays collagen fiber organization and impairs mechanical integration at the insertion site, resulting in a measurable decline in load-to-failure strength and overall tendon toughness. Furthermore, while prolonged inflammation contributes to pathological degeneration, the transient synthesis of PGE2 during the initial hours following injury is essential for regulating localized microvascular flow and hyperemic nutrient delivery. By eliminating this early prostanoid pulse, NSAIDs starve the repair zone of oxygen and circulating factors precisely when the cellular metabolic demand is highest. Beyond direct biochemical cytotoxicity, systemic NSAIDs introduce a physical hazard known as analgesic arthropathy. In musculoskeletal biomechanics, pain functions as a protective feedback mechanism, forcing the patient to unload an injured joint or limb to prevent structural overload. By effectively blunting the pain reflex while simultaneously undermining the cellular synthesis of proteoglycans and collagen, NSAIDs create a deceptive state of perceived recovery. Patients prematurely resume unrestricted weight-bearing and strenuous activity, placing substantial, uncompensated mechanical forces onto compromised cartilage surfaces and unhealed tendon fibers. Over time, this recurring mechanical trauma accelerates joint space narrowing, promotes microfractures in the subchondral plate, and hastens functional joint breakdown. Chondroprotective and Tenogenic Mechanisms of CurcuminIn sharp contrast to the suppressive actions of synthetic COX inhibitors, curcumin exhibits a tissue-sparing, pro-regenerative biological profile. Rather than paralyzing cellular metabolism, curcumin modulates the microenvironment by suppressing destructive catabolic enzymes while supporting the baseline anabolic signals required for cartilage and tendon reconstruction.In articular cartilage, curcumin acts as a direct chondroprotective agent by dismantling the catabolic cascade induced by pro-inflammatory cytokines. When joint tissues are exposed to elevated IL-1ß and TNF-a, chondrocytes are provoked to synthesize matrix metalloproteinases - specifically collagenases such as MMP-1, MMP-3, and MMP-13 - along with aggrecanases like ADAMTS5. These enzymes function like enzymatic shears, systematically slicing through structural Type II collagen strands and degrading aggrecan cores. Curcumin suppresses the transcription and secretion of MMP-1, MMP-3, MMP-13, and ADAMTS5 by neutralizing NF-kB and AP-1 activation. Concurrently, it upregulates Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2), an essential transcriptional regulator that represses matrix metalloproteinases at the genomic level. In addition to halting extracellular degradation, curcumin protects chondrocytes from inflammatory apoptosis. Exposure to oxidative stress and inflammatory cytokines typically triggers programmed cell death by activating the intrinsic caspase cascade. Curcumin suppresses this apoptotic pathway by reducing the cleavage of executioner caspase-3, downregulating the pro-apoptotic factor Bax, and elevating anti-apoptotic Bcl-2 expression. Microscopic and histological analyses of osteoarthritic cartilage treated with curcumin consistently show robust Safranin O staining, intact surface regularity, preserved chondrocyte density, and significantly reduced Osteoarthritis Research Society International (OARSI) degradation scores. Within tendon biology, curcumin promotes active tissue regeneration (tenogenesis) rather than inert scar formation. In animal models of tendon rupture and surgical repair, curcumin guides tendon-derived stem and progenitor cells (TSPCs) toward mature tenocyte differentiation. This lineage-specific differentiation is orchestrated primarily through activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and Wnt/ß-catenin signaling cascades. As stem cells commit to the tenogenic pathway, they significantly upregulate crucial structural and phenotypic markers, including epithelial cell adhesion molecule (EpCAM), tenomodulin, and the master tendon transcription factor Scleraxis. Through this guided differentiation, curcumin supports the preferential synthesis and organized deposition of high-tensile Type I collagen fibers, the primary architectural building blocks of healthy tendons. Injured tendons typically fill with disorganized, loose Type III collagen, which forms a structurally inferior, compliant scar. Curcumin supplementation promotes the progressive maturation from primitive Type III collagen to densely packed, parallel Type I collagen fibrils, restoring native tensile strength and mechanical breaking force. A major clinical challenge following tendon surgery is the development of peritendinous adhesions, in which excessive fibrotic scar tissue binds the healing tendon to its synovial sheath, restricting range of motion and joint gliding. Postoperative tendon repair involves a balance between extrinsic healing (in which exterior fibroblasts infiltrate the defect and deposit messy scar tissue) and intrinsic healing (in which tenocytes within the tendon substance reconstruct the matrix). Curcumin suppresses excessive peritendinous inflammation and extrinsic fibrosis while accelerating intrinsic tenocyte repair. Biomechanical testing confirms that local or systemic curcumin administration yields lower adhesion scores, increased gliding distances, and superior functional mobility without sacrificing structural load-bearing capacity. Comparative Clinical Efficacy and Systemic Safety ProfilesTranslating cellular findings into clinical practice requires weighing therapeutic outcomes against systemic safety profiles. While synthetic NSAIDs deliver potent, rapid analgesia during acute musculoskeletal pain events, their chronic administration is constrained by systemic toxicities across multiple organ systems.In randomized, active-controlled clinical trials of knee osteoarthritis, optimized curcumin preparations have demonstrated clinical pain reduction and functional recovery comparable to standard therapeutic doses of NSAIDs. In a randomized, open-label parallel-arm study evaluating 139 patients with symptomatic knee osteoarthritis, subjects received either 500 mg of a bio-enhanced curcumin extract three times daily or 50 mg of diclofenac sodium twice daily for 28 consecutive days. Patients treated with curcumin demonstrated comparable improvements in pain intensity on the Visual Analogue Scale (VAS) and functional scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) at days 14 and 28, showing no statistically significant difference in therapeutic efficacy compared to diclofenac. However, the systemic tolerability profiles between the treatments diverged markedly. Overall adverse events occurred in only 13% of the curcumin group compared to 38% of the diclofenac cohort. In the diclofenac arm, 28% of patients developed dyspeptic symptoms severe enough to require concurrent treatment with H2-receptor antagonists or proton pump inhibitors to prevent mucosal ulceration, whereas no patients in the curcumin cohort required gastroprotective intervention. Furthermore, the curcumin cohort experienced a significant reduction in flatulence and digestive discomfort, demonstrating beneficial gastric and intestinal cytoprotective effects. These safety observations are consistent across broader systematic reviews and meta-analyses. Nonsteroidal anti-inflammatory agents inherently compromise gastrointestinal integrity by systematically depleting cytoprotective prostaglandins, leaving the gastric epithelium vulnerable to acid erosion and hemorrhage. In addition, systemic inhibition of renal and vascular COX enzymes by NSAIDs reduces renal perfusion and disrupts the balance between prostacyclin and thromboxane, elevating the risk of fluid retention, hypertension, and adverse cardiovascular thrombotic events. Curcumin does not suppress these physiological prostanoid pathways, making it free from ulcerogenic, nephrotoxic, and cardiotoxic properties at therapeutic dosages.
A longstanding limitation of standard curcumin supplementation in clinical settings has been its low oral bioavailability. Native curcuminoids are highly lipophilic, poorly soluble in aqueous gastric fluids, and subject to rapid hepatic and intestinal phase II metabolism into inactive glucuronides and sulfates, leading to swift biliary and fecal excretion. Consequently, raw culinary turmeric powders struggle to achieve the therapeutic systemic circulating concentrations required to reach poorly vascularized joint and tendon compartments. Modern pharmacognosy has addressed this pharmacodynamic hurdle through advanced delivery formulations. Modern strategies - such as co-administration with the natural alkaloid piperine (which inhibits hepatic glucuronidation), micellar dispersions, phytosomal phospholipid complexes, and bio-enhanced submicron dispersions - elevate systemic blood bioavailability by ten- to thirty-fold compared to unformulated extracts. These modern delivery platforms ensure that therapeutic concentrations reach synovial fluid, subchondral bone, and fibrous tendon sheaths without requiring excessive oral dosing. Conclusions and Translational Clinical ImplicationsThe biological and clinical evidence reveals distinct physiological paths for NSAIDs and curcumin in orthopedic recovery. While NSAIDs remain powerful tools for the brief alleviation of acute, unmanageable pain, their ongoing administration during active tissue healing presents substantial biological compromises. Tendons and cartilage require a controlled, transient inflammatory cascade to signal cell recruitment, stimulate stem cell differentiation, and direct extracellular matrix synthesis. By completely shutting down cyclooxygenase enzymes and depleting local prostaglandins, NSAIDs disrupt this regenerative cascade. The resulting cellular consequences - including chondrocyte cell cycle arrest, proteoglycan loss, suppression of tenocyte migration, and weakened collagen tensile strength at the tendon-to-bone interface - demonstrate that pain relief from NSAIDs frequently comes at the cost of the structural integrity of healing connective tissues.In contrast, curcumin provides a tissue-preserving alternative that decouples pain and inflammation control from cellular suppression. Operating upstream at the level of NF-kB and AP-1 transcriptional activation, curcumin attenuates the expression of pro-inflammatory cytokines while leaving the physiological baseline of cellular metabolism intact. In cartilage, it actively represses the matrix-degrading enzymes MMP-1, MMP-3, MMP-13, and ADAMTS5, maintains water-binding proteoglycan content, and protects chondrocytes from inflammatory apoptosis. In damaged tendons, curcumin stimulates tenogenic differentiation of local stem cells via PI3K/Akt signaling, supports the proper maturation of dense Type I collagen fibers, and prevents restrictive peritendinous scar adhesions, preserving both joint mobility and mechanical breaking strength. From a translational perspective, these findings indicate that clinical protocols should reconsider relying on continuous NSAIDs as the default intervention for connective tissue injuries, post-surgical recovery, and chronic degenerative conditions. Where synthetic NSAIDs are deemed necessary, their use should be confined to short-term acute flare-ups to avoid interrupting early tissue remodeling. For long-term joint preservation, ongoing tendinopathy rehabilitation, and chronic osteoarthritis management, optimized bio-enhanced curcumin formulations deliver pain relief and functional restoration comparable to conventional pharmaceuticals, all while preserving the biological processes required for lasting musculoskeletal repair. References: NSAID therapy effects on healing of bone, tendon, and the enthesis The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Conservative management of symptomatic knee osteoarthritis - PMC Positives and negatives of nonsteroidal anti-inflammatory drugs in (PDF) Conservative management of symptomatic knee osteoarthritis Non-steroidal anti-inflammatory drugs influence cartilage healing Is Curcumine Useful in the Treatment and Prevention of ... - PMC - NIH Efficacy and mechanisms of curcumin in the treatment of osteoarthritis Biological actions of curcumin on articular chondrocytes - PubMed Curcumin slows osteoarthritis progression and relieves ... - PMC - NIH Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Anti-inflammatory management for tendon injuries - friends or foes? The mechanistic role of curcumin on matrix metalloproteinases in Therapeutic effects of turmeric or curcumin extract on pain and Curcumin inhibits chondrocyte apoptosis and inflammation in ... - PMC Analysis of the mechanism of curcumin against osteoarthritis using Synergistic enhancement of tendon-to-bone healing via anti ... - PMC A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis A randomized, pilot study to assess the efficacy and safety ... - PubMed Effectiveness of curcuminoids in the treatment of knee osteoarthritis THE EFFECTS OF TRADITIONAL STRENGTHENING EXERCISES Putting Some Muscle into Osteoarthritis | Annals of Internal Medicine Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Calebin A, a Compound of Turmeric, Down-Regulates Inflammation The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to Chiropractor in Toronto, ON, Canada :: Head and Neck Pain Investigation of the association of long-term NSAID use with ... - PMC Curcumin Improves Functional Recovery of Ruptured Tendon by Chemically modified curcumin (CMC2.24) alleviates osteoarthritis Curcumin improves age-related and surgically induced osteoarthritis (PDF) Curcumin Improves Functional Recovery of Ruptured Tendon Investigation of the effects of umbilical cord-derived mesenchymal Effect of curcumin-loaded polycaprolactone scaffold on Achilles Controlled release of curcumin from curcumin-loaded nanomicelles Efficacy and safety of combination of curcuminoid complex ... - PMC The efficacy of Curcuma Longa L. extract as an adjuvant therapy in
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6653) The Ultimate Guide to Cellular Longevity: NAD+, Methylation, and Senolytics 
Date:
September 10, 2026 10:57 AM
Introduction: Understanding Cellular Aging and Energy DeclineBiological aging represents a progressive decline in cellular maintenance, structural repair, and energy generation. Over decades, tissues experience an attrition of functional reserves, compromised stress resilience, and persistent low-grade systemic inflammation. At the cellular scale, biological degeneration is driven by a failure to generate bioenergetic fuel, repair genetic code, and clear metabolic waste.Cellular aging is characterized by interconnected biological disruptions known as the hallmarks of aging. These encompass genomic instability, epigenetic alterations, mitochondrial decay, loss of proteostasis, and cellular senescence. Rather than operating as isolated occurrences, these phenomena establish a self-reinforcing degenerative cycle: declining cellular power generation impairs enzymatic genetic repair, promoting the accumulation of damaged cells that enter irreversible growth arrest and poison surrounding healthy tissues. Mitigating cellular aging requires examining how microscopic bioenergetic pathways deteriorate and evaluating how targeted nutritional and biochemical interventions can restore cellular homeostasis. The Role of Mitochondria and ATP ProductionEvery biological function - from muscular contraction to continuous DNA replication - depends on adenosine triphosphate (ATP), the primary biochemical energy currency of living systems. Cells produce the vast majority of this energy within mitochondria through oxidative phosphorylation. Within these specialized organelles, metabolic intermediates derived from dietary carbohydrates and lipids donate high-energy electrons to the electron transport chain. The flow of these electrons across protein complexes establishes an electrochemical proton gradient across the inner mitochondrial membrane, driving ATP synthase to manufacture ATP.A youthful cell functions like an efficient municipal power grid, dynamically matching energetic demands with immediate ATP output. However, as biological aging progresses, mitochondrial efficiency declines. The electron transport chain becomes structurally leaky, inadvertently shedding electrons that react with ambient molecular oxygen to produce reactive oxygen species (ROS). While regulated levels of ROS participate in vital intracellular signaling, chronic excess induces widespread oxidative stress. Mitochondria are exceptionally vulnerable to this oxidative burden because they carry their own circular genetic material, known as mitochondrial DNA (mtDNA). Unlike nuclear DNA, mtDNA lacks the protective shielding of histone proteins and possesses rudimentary repair systems. As a result, mtDNA sustains cumulative oxidative damage, encoding increasingly defective electron transport chain proteins. This dynamic generates a bioenergetic deficit: degraded mitochondria synthesize progressively less ATP while emitting greater volumes of damaging free radicals. Deprived of optimal ATP reserves, cells lack the energy necessary to drive vital enzymatic repair cascades, accelerating structural degeneration and functional exhaustion. How Cellular Senescence Accelerates the Aging ProcessWhen healthy cells confront critical physiological damage - such as severe telomere attrition, persistent DNA double-strand breaks, or oxidative stress - they activate protective cell cycle arrest pathways governed primarily by the p53/p21^CIP1 and p16^INK4a/Rb molecular checkpoints. This defensive shutdown, termed cellular senescence, permanently prevents the replication of potentially premalignant or mutated cells.Senescent cells, colloquially known as "zombie cells," enter a state of permanent growth arrest while actively resisting programmed cell death (apoptosis). Over time, these cells accumulate within adipose depots, skeletal muscle, the vascular endothelium, and major organs, largely because immune surveillance and clearance pathways simultaneously lose functional efficiency. The systemic danger of senescent cells stems from their secretome. Rather than remaining biologically inert, senescent cells develop a hyperactive secretory state termed the Senescence-Associated Secretory Phenotype (SASP). The SASP is a destructive mixture of pro-inflammatory cytokines, chemokines, extracellular matrix-degrading matrix metalloproteinases (MMPs), and reactive oxygen species. Through this toxic secretome, even a small burden of senescent cells can impair whole-tissue architecture. SASP factors degrade surrounding structural proteins, induce insulin resistance in neighboring metabolic cells, and biochemically force adjacent healthy cells into secondary senescence. This persistent paracrine signaling fuels chronic, sterile, low-grade systemic inflammation, termed "inflammaging," which accelerates systemic tissue degeneration and elevates susceptibility to degenerative age-related pathologies. Nicotinamide Riboside (NR) and the NAD+ Salvage PathwayThe Biochemistry of NAD+ Depletion Over TimeNicotinamide adenine dinucleotide (NAD+) is an indispensable coenzyme present in every living cell. NAD+ fulfills a dual biological mandate: it serves as a central redox cofactor that shuttles electrons between cellular metabolic reactions, and it functions as an obligatory consumable substrate for regulatory enzymes that preserve cellular viability. In its redox capacity, NAD+ accepts electrons to form NADH during glycolysis, the tricarboxylic acid (TCA) cycle, and fatty acid beta-oxidation, subsequently donating those electrons to Complex I of the respiratory chain to power ATP synthesis.
The primary enzymatic driver of age-related NAD+ destruction is CD38, a membrane-bound glycohydrolase expressed on immune cells that is upregulated in response to chronic SASP exposure. Concurrently, lifelong genotoxic damage causes persistent activation of Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that cleaves the glycosidic bonds of NAD+ to assemble branched poly(ADP-ribose) chains at DNA lesion sites. Because PARP-1 consumes NAD+ without directly recycling the molecule, chronic DNA damage depletes intracellular NAD+ pools, impairing bioenergetics and limiting sirtuin activity. How NR Efficiently Boosts Cellular NAD+ LevelsThe mammalian body maintains its NAD+ supply through three distinct biosynthetic routes: the de novo pathway from dietary L-tryptophan, the Preiss-Handler pathway from nicotinic acid (niacin), and the NAD+ Salvage Pathway. The de novo pathway requires substantial energy expenditure, consuming roughly sixty milligrams of dietary tryptophan to yield a single milligram of NAD+. The Preiss-Handler pathway, while effective, can induce cutaneous prostaglandin-mediated flushing at therapeutic intakes. Consequently, the salvage pathway serves as the primary mechanism for maintaining intracellular NAD+ pools.The salvage pathway recycles the breakdown product nicotinamide (NAM), which is released whenever NAD+-consuming enzymes execute their functions. Under normal conditions, cells convert free nicotinamide into nicotinamide mononucleotide (NMN) via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), after which NMN adenylyltransferases (NMNAT1–3) complete the conversion into NAD+. However, NAMPT expression declines with advancing age, chronic inflammation, and metabolic stress, limiting the recycling capacity of the cell. Nicotinamide Riboside (NR) is a naturally occurring pyridine nucleoside that bypasses this enzymatic bottleneck. Upon cellular entry via equilibrative nucleoside transporters, NR is directly phosphorylated into NMN by nicotinamide riboside kinases (NRK1 and NRK2) using a single molecule of ATP. Because the NRK pathway remains intact and robust across the lifespan, NR provides an efficient alternative entry point into the NAD+ salvage cascade. Clinical evaluations in humans confirm the safety, bioavailability, and pharmacokinetics of oral NR supplementation. Randomized, double-blind, placebo-controlled trials reveal that oral NR chloride produces dose-dependent increases in steady-state whole blood NAD+ concentrations. Dosing regimens of 100 mg, 300 mg, and 1,000 mg daily elevate blood NAD+ levels by approximately 22%, 51%, and up to 142%, respectively, within two weeks of administration, maintaining these elevations throughout continuous use. High-resolution metabolomic analyses also demonstrate parallel elevations in nicotinic acid adenine dinucleotide (NAAD), establishing it as a reliable biomarker of active intracellular NAD+ synthesis without hepatic or systemic toxicity. Sirtuin Activation and DNA Repair MechanismsReplenishing intracellular NAD+ supports functions beyond mitochondrial ATP generation. NAD+ functions as an obligatory cofactor for sirtuins (SIRT1 through SIRT7), a family of class III histone and non-histone protein deacetylases that regulate stress resilience, metabolic homeostasis, and cell survival. Sirtuins couple the removal of acetyl groups from target lysine residues to the stoichiometric cleavage of NAD+, producing nicotinamide and O-acetyl-ADP-ribose. In states of NAD+ deficiency, sirtuin enzymes remain inactive regardless of cellular demand.In the nucleus, SIRT1 coordinates defense against cellular decline. When activated by restored NAD+ levels, SIRT1 deacetylates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a), the master transcriptional coactivator of mitochondrial biogenesis. This deacetylation stimulates mitochondrial replication and assembly, expanding functional respiratory capacity. Concurrently, SIRT1 deacetylates the p65 subunit of nuclear factor-kappa B (NF-kB), suppressing the transcription of pro-inflammatory cytokines. In the mitochondria, SIRT3 utilizes NAD+ to deacetylate metabolic enzymes and superoxide dismutase 2 (SOD2), enhancing the organelle's capacity to neutralize reactive oxygen species. At the same time, cellular NAD+ levels directly regulate genomic integrity through PARP-1. When genotoxic stress or oxidative damage induces single- or double-strand DNA breaks, PARP-1 binds to the damaged termini using its zinc-finger domains. Bound PARP-1 hydrolyzes NAD+ to synthesize extensive, negatively charged poly(ADP-ribose) polymers on itself and adjacent histones. This modification relaxes chromatin architecture and establishes an electrostatic scaffold that recruits base excision repair and homologous recombination complexes. Recent discoveries demonstrate close crosstalk between sirtuins and PARP-1 during DNA repair. PARP-1 recruits SIRT1 to double-strand breaks, where SIRT1 deacetylates the chromatin-remodeling ATPase BRG1 to displace nucleosomes and facilitate homologous recombination. However, because PARP-1 and SIRT1 draw from the same intracellular NAD+ pool, severe NAD+ depletion forces a biological compromise: PARP-1 consumes the scarce remaining cofactor to address DNA damage, leaving sirtuins deactivated. Restoring NAD+ via NR prevents this deficit, enabling concurrent genomic repair and sirtuin-mediated metabolic defense. Quercetin: A Powerful Senolytic and mTOR RegulatorClearing Senescent "Zombie" Cells from TissuesThe accumulation of senescent cells has driven interest in senolytics: molecules that selectively eliminate senescent cells while sparing healthy, non-senescent populations. Senolytic agents exploit a specific vulnerability in senescent cells. Because senescent cells produce cytotoxic, pro-inflammatory SASP factors that would normally induce their own death, they become dependent on upregulated Senescent Cell Anti-Apoptotic Pathways (SCAPs) to survive. The SCAP network involves anti-apoptotic proteins (such as BCL-2 and BCL-xL), the PI3K/Akt kinase cascade, and cyclin-dependent kinase inhibitors.Quercetin is a polyphenolic flavonoid found in capers, red onions, apples, and the flower buds of Sophora japonica. Beyond its classical antioxidant properties, quercetin functions as a senolytic compound that exerts multi-target inhibitory effects across the SCAP network. By inhibiting the upstream PI3K/Akt survival axis and downregulating anti-apoptotic defenses, quercetin disrupts the signaling that protects senescent cells from intrinsic apoptosis. Deprived of these survival signals, senescent cells undergo programmed cell death. Preclinical studies demonstrate that senolytic protocols utilizing quercetin - often combined with the tyrosine kinase inhibitor dasatinib - reduce senescent cell burden across multiple tissues. This targeted clearance lowers circulating SASP factors, attenuates tissue fibrosis, restores endothelial reactivity, and improves functional health span. By removing senescent cells, quercetin mitigates the primary driver of chronic, low-grade inflammaging. Modulating the mTOR Pathway for Optimal AutophagyThe mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that coordinates cellular metabolism by balancing anabolic growth with catabolic recycling. Operating within two multiprotein complexes - mTORC1 and mTORC2 - the mTOR pathway integrates signals from amino acids, growth factors, and intracellular energy levels. In nutrient-rich environments, mTORC1 promotes protein synthesis, lipogenesis, and cellular growth, while suppressing catabolic breakdown. Conversely, nutrient scarcity downregulates mTORC1, activating autophagy.Autophagy is an intracellular degradation system that packages damaged organelles, misfolded protein aggregates, and biological debris into double-membraned autophagosomes for lysosomal degradation and recycling. A specialized branch of this pathway, mitophagy, selectively targets and clears damaged mitochondria. In modern metabolic conditions characterized by continuous caloric intake, mTORC1 can remain persistently active. This persistent signaling suppresses autophagy, causing damaged organelles and toxic aggregates to accumulate within tissues. Quercetin functions as a natural modulator of mTOR signaling. By inhibiting upstream PI3K/Akt signaling and activating intracellular energy sensors, quercetin attenuates overactive mTORC1, mimicking the metabolic effects of caloric restriction. This down-regulation relieves inhibition on the ULK1 autophagy initiation complex, stimulating both general autophagy and mitophagy. As autophagy proceeds, cells clear protein aggregates and eliminate damaged mitochondria, supporting cellular longevity and proteostasis. Enhancing Absorption: Phytosomes and Dietary FatsDespite the biological activities of quercetin identified in experimental models, its clinical translation has historically been limited by poor oral bioavailability. Raw quercetin aglycone is a crystalline, hydrophobic polyphenol with poor solubility in water and gastrointestinal fluids. When ingested in unformulated powder forms, quercetin molecules aggregate in the gut lumen, resisting dissolution and passive absorption. Consequently, the vast majority of an unformulated dose passes into the colon unabsorbed, where it undergoes microbial degradation without reaching meaningful systemic concentrations.To address these pharmacokinetic limitations, advanced delivery systems such as phytosomes were engineered. A phytosome is a 100% food-grade molecular complex where individual polyphenolic molecules are bound to dietary phospholipids, typically sunflower-derived phosphatidylcholine. Unlike a classical liposome - which encapsulates water-soluble compounds inside an aqueous core enclosed by a lipid bilayer - a phytosome forms an amphiphilic complex at the molecular level. The polar head of the phosphatidylcholine molecule forms hydrogen bonds with the hydroxyl groups of the quercetin molecule, while its lipophilic fatty acid tails extend outward. This structural arrangement shields the polar regions of the flavonoid, creating a lipid-compatible complex that integrates smoothly into the intestinal mucosa.
The Importance of Methylation in Healthy AgingVitamin B-Complex and Choline as Essential Methyl DonorsMethylation is an essential biochemical process occurring billions of times each second across all human tissues. It involves the transfer of a single-carbon unit - a methyl group consisting of one carbon atom bound to three hydrogen atoms - (CH3) - from a donor molecule to diverse recipients, including DNA, RNA, structural proteins, neurotransmitters, and membrane phospholipids. This transfer of one-carbon units is coordinated by the methionine-homocysteine cycle, which sustains genetic stability, detoxification pathways, and cellular repair.At the center of this pathway sits S-adenosylmethionine (SAM), the universal methyl donor in human biology. When a methyltransferase enzyme transfers a methyl group from SAM to an acceptor molecule, SAM is converted into S-adenosylhomocysteine (SAH). SAH functions as a potent competitive inhibitor of intracellular methyltransferases. To maintain functional methylation, SAH is rapidly hydrolyzed into homocysteine, a sulfur-containing amino acid that must be remethylated or cleared through transsulfuration. Homocysteine clearance proceeds through two distinct remethylation pathways. The primary route operates across most tissues via the enzyme methionine synthase, which requires vitamin B12 in its active methylcobalamin form. Methionine synthase transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF, the active form of folate) to homocysteine, regenerating methionine. The ongoing production of 5-MTHF depends on the enzyme methylenetetrahydrofolate reductase (MTHFR), which utilizes riboflavin (vitamin B2) as a cofactor. Alternatively, excess homocysteine can be routed into the transsulfuration pathway by vitamin B6 (as pyridoxal-5'-phosphate) to synthesize cystathionine, cysteine, and ultimately the antioxidant glutathione. A secondary remethylation pathway, active predominantly in hepatic and renal tissues, bypasses folate entirely. In this route, dietary choline is oxidized to betaine (trimethylglycine or TMG). The enzyme betaine-homocysteine S-methyltransferase (BHMT) then transfers a methyl group from betaine directly to homocysteine, yielding methionine and dimethylglycine. When dietary intake of active B-vitamins or choline is insufficient, or when genetic variations like MTHFR polymorphisms reduce pathway flux, the methylation cycle slows. Homocysteine accumulates in circulation, promoting vascular and neurological inflammation, while SAM reserves decline, restricting cellular methylation capacity. Understanding DNA Methylation and Epigenetic HealthEvery somatic cell in an organism carries an identical genetic code. Cellular differentiation and tissue-specific functions are governed by the epigenome: a regulatory layer of chemical modifications that dictates gene expression without altering underlying DNA sequences. DNA methylation represents the primary and most stable epigenetic modification. In this process, DNA methyltransferase (DNMT) enzymes utilize methyl groups donated by SAM to add a methyl tag to cytosine bases adjacent to guanine residues, forming 5-methylcytosine within CpG dinucleotide sites.Under physiological conditions, DNA methylation maintains genomic stability and coordinates transcription. Methylation of promoter regions condenses chromatin, repressing transposable elements and silencing genes inappropriate for a given cell type. Conversely, hypomethylated promoters maintain an open chromatin state, allowing transcription factors to bind and initiate gene expression. During biological aging, this epigenetic landscape undergoes progressive dysregulation, a phenomenon termed "epigenetic drift". Aging cells experience global hypomethylation alongside focal hypermethylation of specific gene promoters. Global loss of methyl tags destabilizes the genome, activating retrotransposons and pro-inflammatory pathways. Simultaneously, hypermethylation at targeted promoter sites silences critical tumor suppressor genes and DNA repair complexes. This systematic change in DNA methylation patterns is consistent across populations, allowing researchers to develop molecular "epigenetic clocks". Algorithms such as the Horvath clock, PhenoAge, and GrimAge quantify biological age by profiling the methylation status of specific CpG sites across the genome. These clocks assess whether individuals are aging faster or slower than their chronological years. Ensuring a steady supply of methyl donors and preventing unnecessary SAM depletion supports DNMT activity, maintaining epigenetic patterns and genomic stability. How the Methylation Cycle Impacts Energy and Cognitive FocusBeyond long-term epigenetic regulation, the methylation cycle directly modulates immediate biochemical processes that govern daily energy, neurotransmission, and cognitive focus. Compromised methylation capacity frequently manifests as cognitive slowing, executive fatigue, and reduced physical stamina.A major consumer of methyl reserves is the endogenous synthesis of creatine. Approximately 40% of all SAM-derived methyl groups in the human body are utilized by guanidinoacetate N-methyltransferase (GAMT) in the liver to synthesize creatine. Creatine then translocates to the brain and skeletal muscle, where it is phosphorylated into phosphocreatine. Phosphocreatine functions as a rapid energy buffer, donating a high-energy phosphate group to regenerate ADP into ATP in milliseconds during demanding physical or cognitive tasks. When methyl donor availability falls, endogenous creatine synthesis drops, depleting phosphocreatine reserves and increasing susceptibility to neuromuscular and cognitive fatigue. Methylation is equally central to central nervous system architecture. SAM provides methyl groups to convert phosphatidylethanolamine into phosphatidylcholine, the predominant phospholipid comprising neuronal cell membranes and the myelin sheaths that insulate axons. Intact myelin preserves rapid action potential conduction throughout the nervous system. Furthermore, free choline derived from this pathway is the direct precursor to acetylcholine, the neurotransmitter required for attention, working memory, and learning. The methylation cycle also governs monoamine neurotransmitter metabolism. SAM is required for the synthesis of adrenaline (epinephrine) from noradrenaline, while catechol-O-methyltransferase (COMT) relies on SAM to degrade dopamine and norepinephrine within the prefrontal cortex. Sluggish methylation disrupts this balance, contributing to cognitive fatigue, mood variability, and impaired mental performance. Building a Comprehensive Longevity ProtocolSynergizing NR, Quercetin, and Methylated B-VitaminsLongevity supplementation often falters when single molecules are administered in isolation, ignoring interconnected metabolic pathways. Designing an effective cellular longevity protocol requires combining complementary mechanisms that reinforce one another while preventing secondary metabolic deficits. The combination of Nicotinamide Riboside, Quercetin Phytosome, and Methylated B-Vitamins illustrates this multi-target synergy.This synergy is grounded in the direct biochemical intersection between the NAD+ salvage pathway and the methylation cycle. When high-dose NR is supplemented to boost systemic NAD+, sirtuins and PARP enzymes consume the newly synthesized cofactor, generating substantial quantities of free nicotinamide (NAM). This intracellular nicotinamide faces two primary metabolic fates: it can be recycled back into NAD+ through the NAMPT-dependent salvage loop, or it can be cleared via methylation. When the influx of nicotinamide exceeds salvage recycling capacity, the excess is cleared to avoid feedback inhibition of sirtuin enzymes. To accomplish this, the enzyme nicotinamide N-methyltransferase (NNMT) transfers a methyl group from SAM directly onto nicotinamide, forming 1-methylnicotinamide (1-MNA/MNAM), which is subsequently excreted in urine. Prolonged, high-dose precursor administration without nutritional methyl support can elevate NNMT flux, depleting intracellular SAM reserves. As methyl groups are consumed clearing nicotinamide, the cellular SAM-to-SAH ratio falls, which can elevate circulating homocysteine and reduce methyl availability for DNA methylation and neurotransmitter synthesis. Co-administering a fully methylated B-complex alongside choline or betaine addresses this potential bottleneck. Providing active methyl donors (such as 5-MTHF, methylcobalamin, and betaine) maintains the one-carbon donor pool. Even during increased NNMT activity, SAM pools remain stable, protecting DNA methylation fidelity and maintaining homocysteine within safe parameters. Quercetin reinforces this protocol through complementary mechanisms. By clearing senescent cells and reducing SASP-mediated inflammation, quercetin downregulates CD38, the primary enzyme responsible for age-related NAD+ degradation. Suppressing CD38 prevents unnecessary breakdown of newly synthesized NAD+, enhancing the efficiency of NR supplementation. Furthermore, while NR provides the NAD+ necessary to activate SIRT1-driven mitochondrial biogenesis, quercetin concurrently modulates mTORC1 to stimulate autophagy. This coordinated action ensures that newly generated mitochondria operate in an environment cleared of proteotoxic cellular debris. The Crucial Role of Magnesium Glycinate and Zinc in Cellular FunctionLongevity protocols require essential mineral cofactors to function efficiently. Without adequate divalent minerals acting as enzymatic cofactors and structural stabilizers, metabolic longevity pathways cannot operate at full capacity. Among these, magnesium and zinc are required for cellular repair, genomic stability, and energy production.Magnesium serves as an obligatory cofactor in over 300 enzymatic reactions, primarily through its interaction with ATP. In biological systems, ATP exists predominantly as a chelate with a divalent magnesium ion, forming biologically active Mg2+ -ATP. Every enzymatic reaction that synthesizes, transfers, or consumes cellular energy - including the enzymes of the NAD+ salvage pathway (NRK and NMNAT) and DNA polymerases - strictly requires Mg2+ -ATP as its substrate. Magnesium deficiency impairs these phosphorylation reactions, reducing the cellular utilization of NAD+ precursors. Additionally, magnesium is an essential cofactor for the enzymes that activate dietary B-vitamins into their active forms. Supplying magnesium as magnesium glycinate provides high gastrointestinal bioavailability, minimal laxative effect, and yields glycine to support inhibitory neurotransmission and restful sleep. Zinc serves as a vital structural component for more than 3,000 human transcription factors and enzymatic proteins. Its most prominent structural role in longevity occurs within zinc-finger motifs. These are specialized protein conformations stabilized by a zinc ion coordinated to cysteine and histidine residues. The DNA damage sensor PARP-1 utilizes three zinc-finger domains to identify, track, and physically bind to single- and double-strand DNA breaks. Without adequate intracellular zinc, PARP-1 cannot properly assemble or dock onto damaged chromosomes, impairing DNA repair and increasing genomic instability. Zinc is also an obligatory structural component of copper/zinc superoxide dismutase (Cu/Zn-SOD or SOD1), the primary cytosolic antioxidant enzyme that dismutates superoxide radicals into hydrogen peroxide, protecting mitochondrial membranes and nuclear DNA from premature senescence. Integrating Prebiotics (like Acacia and Inulin) for Gut-Derived Longevity MarkersA comprehensive cellular longevity framework must extend beyond somatic tissues to encompass the gut microbiome. The intestinal microbiome functions as a central regulator of systemic inflammatory tone, immune development, and metabolic signaling. Age-associated dysbiosis - characterized by the loss of beneficial commensals and an overgrowth of pathobionts - frequently leads to breakdown of the intestinal barrier.The gut epithelium consists of a single-cell monolayer sealed by tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and claudins. When this physical barrier is disrupted by poor dietary fiber intake or dysbiosis, gut permeability increases. This allows lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, to enter the portal and systemic circulation. The resulting "metabolic endotoxemia" activates Toll-like receptor 4 (TLR4) on immune cells, inducing NF-kB and systemic pro-inflammatory cytokine production. This persistent gut-derived inflammation exacerbates the SASP, accelerates tissue senescence, upregulates CD38, and drains systemic NAD+ reserves.
These short-chain fatty acids, particularly butyrate, exert direct protective effects on systemic longevity. Butyrate provides the primary metabolic fuel for colonic epithelial cells, supplying more than 70% of their baseline energy needs and supporting mitochondrial function within colonocytes. Furthermore, SCFAs upregulate the expression of epithelial tight junction proteins (ZO-1, occludin, and claudin-1), restoring intestinal barrier integrity and preventing the translocation of inflammatory LPS into systemic circulation. Systemically absorbed butyrate also functions as an endogenous histone deacetylase (HDAC) inhibitor, suppressing pro-inflammatory gene expression and supporting regulatory T cell (T_reg) development. Reducing metabolic endotoxemia dampens systemic inflammation, protecting vascular function and preventing premature NAD+ depletion. Conclusion: The Integrated Cellular Longevity MatrixCellular longevity is achieved not by addressing isolated biomarkers in isolation, but by systematically supporting interconnected biological pathways. As bioenergetic capacity declines, cellular senescence accelerates, epigenetic patterns degrade, and gut barrier integrity weakens. A comprehensive approach addresses these biological vulnerabilities simultaneously.
Quercetin Phytosome clears senescent cells and modulates mTORC1, stimulating autophagy while dampening the inflammatory SASP cascade that accelerates CD38-mediated NAD+ destruction. Methylated B-vitamins, active folate, and choline replenish SAM reserves, balancing the methyl requirements of NNMT-mediated nicotinamide clearance, preserving epigenetic DNA methylation, and maintaining neurotransmitter production. Magnesium glycinate and zinc provide the structural and catalytic foundation required for ATP utilization, B-vitamin activation, and PARP-1 zinc-finger DNA repair docking. Finally, prebiotic fibers generate short-chain fatty acids like butyrate, reinforcing the intestinal barrier and preventing metabolic endotoxemia from fueling systemic inflammation. By coordinating energy replenishment, cellular waste clearance, epigenetic maintenance, and the suppression of systemic inflammation, this unified approach directly addresses the underlying drivers of cellular aging to support long-term physiological vitality.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6650) Is there anything else DLPA can do be sides Pain management and Mood?
Date:
May 22, 2026 04:29 PM
Here is what else DLPA can do:
When diving deeper into the physiological applications of DLPA, there are several advanced, highly specific mechanisms that make it particularly interesting, especially regarding athletic performance, metabolic pathways, and cellular recovery.
Here are a few of the more complex, nuanced roles of DLPA in the body:
By supplementing with L-phenylalanine, the brain has a steady supply of precursor material to maintain dopamine synthesis. This helps delay the onset of CNS fatigue, allowing for sustained mental drive, higher intensity, and better neurological output throughout a grueling session.
Because the D-phenylalanine in DLPA does not interfere with inflammation or COX enzymes—working entirely by shielding circulating endorphins—it provides musculoskeletal comfort without compromising the cellular signaling required for muscle repair and growth. It allows the body's natural inflammatory repair mechanisms to run their course uninterrupted.
The enzyme responsible for this final step (PNMT) relies entirely on S-adenosylmethionine (SAMe) to donate a methyl group. If the methylation cycle is sluggish or deficient in necessary cofactors (like methylated B-vitamins), the catecholamine cascade bottlenecks at norepinephrine. Therefore, DLPA's ability to fully support the adrenal axis is directly dependent on the efficiency of the body's methylation pathways.
Would you like to explore how to position this mTOR-safe, CNS-supporting angle into a specific educational breakdown for a retail or blog audience?
Summary:
Beyond its foundational role in chronic pain relief, DLPA serves as a versatile precursor that supports several advanced metabolic, cognitive, and physical functions. Because the L-phenylalanine half converts into tyrosine, it provides the essential raw materials required for thyroid hormone synthesis (T3 and T4), melanin skin pigmentation production, and the release of cholecystokinin (CCK), a gut peptide that signals satiety and regulates appetite. Furthermore, by elevating dopamine and norepinephrine, DLPA enhances executive function, working memory, and focus, making it a valuable asset in nootropic protocols and a supportive tool for rebuilding depleted neurotransmitter stores during substance recovery.
In the context of high-intensity athletic performance, DLPA offers unique physiological advantages for training and recovery. It directly combats central nervous system (CNS) fatigue by replenishing the dopamine depleted during heavy resistance training, thereby maintaining neural drive without interrupting muscle protein synthesis. Unlike traditional NSAIDs, which blunt the acute inflammatory response and stall the mTOR pathway, DLPA provides musculoskeletal comfort solely by shielding endogenous opioids (endorphins and enkephalins) from enzymatic breakdown. This allows the natural muscle-repair mechanisms to run their course uninterrupted while simultaneously prolonging the post-exercise "lifter's high." However, its full efficacy remains dependent on a healthy methylation cycle, as the final conversion of norepinephrine to adrenaline requires adequate methyl donors like SAMe.
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Date:
July 16, 2025 11:08 AM
Potential side effects of borage seed oil are typically mild and may include digestive issues such as bloating, gas, or indigestion. As with any supplement, it is advisable to consult with a healthcare professional before starting to take borage seed oil, especially for those who are pregnant, breastfeeding, or taking other medications, particularly blood thinners or anti-seizure drugs.
In conclusion,
Borage seed oil, rich in GLA, is a valuable natural supplement with many potential health benefits. Its ability to modulate cellular inflammation makes it a compelling option for supporting skin, managing arthritis, and easing hormonal discomfort.
Here are even more concise versions:
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Date:
December 07, 2023 12:12 PM
Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body. While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption. GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age. The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels. In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body. This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form. But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them. So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing! When it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ. Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds. During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances? But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker! The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning. So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being! Alcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells. To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes. The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group. The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver. Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels. Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy. In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management. By activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions. Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores. Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects. Skin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract. The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women. In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH. Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin. The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities. In summary, the administration of
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Date:
August 04, 2023 02:09 PM
The typical Western diet is largely comprised of processed foods, which are notoriously high in processed table salt. This results in an imbalance in the sodium to potassium ratio, a significant health concern. Sodium is necessary for a variety of bodily functions; however, too much can be detrimental, leading to hypertension and other cardiovascular diseases. Simultaneously, potassium is often neglected, despite its crucial role in muscle function, nerve signaling, and balancing fluids.
The general dietary advice suggests a potassium to sodium intake ratio of 3:1. However, the reality in diets, particularly those in America, often sees this ratio inverted. The excessive sodium consumption is linked to a myriad of health complications, including high blood pressure and heart disease. Conversely, potassium, a mineral that aids in nerve function and muscle control, is consumed in insufficient quantities. This is a troubling trend that underscores the importance of dietary change towards natural, unprocessed foods.
The importance of potassium is often overshadowed by the emphasis on limiting sodium for reducing chronic disease risk factors. Potassium plays an essential role in maintaining healthy blood pressure levels by counteracting the effects of sodium. Furthermore, the mineral is crucial for other functions like heart and muscle cell functioning, nerve transmission, and maintaining fluid balance.
A study published in the New England Journal of Medicine discovered that individuals with the lowest risk for heart complications or death from any cause were those consuming between four to six grams of sodium per day. This is a fascinating discovery, as this intake is significantly higher than the U.S. daily recommended limits. It suggests a need for a reconsideration of current sodium intake guidelines.
Another consideration to balance the sodium-potassium ratio is the type of salt consumed. Unprocessed, natural salts like sea salt and Himalayan salt contain higher potassium levels compared to standard table salt. These natural salts provide a variety of minerals and trace elements that contribute to our overall health and wellness. It's crucial to note that switching to natural salt should be part of a broader shift towards a diet rich in fresh, unprocessed foods.
Why You Should Focus on Increasing Potassium
While it's beneficial to monitor and moderate sodium intake, it's equally important to shift our focus towards increasing potassium consumption. Potassium-rich foods, such as leafy green vegetables, bananas, potatoes, and beans, not only contribute to a well-rounded and nutritious diet but also help in maintaining an optimal sodium-potassium balance in the body. A high potassium intake can counteract the effects of sodium, aiding in blood pressure regulation and reducing the risk of cardiovascular diseases. Moreover, an elevated potassium level supports various bodily functions, including nerve transmission, muscle contraction, and fluid balance. Thus, prioritizing potassium intake forms a cornerstone for an overall healthier dietary approach. It is recommended that individuals consume 5 grams of potassium daily and potassium to salt ratio should be 2 to 1. To boost potassium intake, one can take a potassium supplement or add the following foods to their diet or both: Watermelon, Orange juice, Boiled red potatoes, Avocado, Bananas, Cantaloupe, Oranges, Coconut water, Tomatoes, Yogurt, Winter squash, and Wild-caught salmon.
Why Low-Salt Advice Can Be Harmful
Contrary to popular belief, adhering to low-salt advice can sometimes pose risks to certain individuals. While it is true that excessive sodium intake can lead to high blood pressure and heart problems, sodium still plays a vital role in our bodies. It assists in nerve conduction, muscle contraction, and maintaining the body's fluid balance.
In fact, low sodium levels in the body, a condition known as hyponatremia, can lead to symptoms such as headache, nausea, fatigue, and in severe cases, coma or even death. Moreover, a low-salt diet may lead to increased levels of cholesterol and triglycerides, hormonal imbalances and insulin resistance. This can potentially elevate the risk of developing cardiovascular disease.
Low-salt diets can also exacerbate the risk of certain health conditions. For instance, individuals with conditions like Addison's disease or certain kidney disorders, where the body struggles to maintain a balance of electrolytes, might find a low-salt diet harmful.
Therefore, it is crucial to balance the intake of sodium, considering both the potential risks associated with too much, or too little, sodium. The key is to consume sodium from natural and unprocessed sources, such as Himalayan salt, fruits, vegetables, grains, and lean meats, which also provide a host of other nutrients necessary for overall health. As with most things in nutrition, moderation and balance seem to hold the answer rather than extreme restriction. The RDA - recommended daily allowance of sodium is 3.5 grams. It is advised to consume 3.5 grams of natural salt each day by way of foods or combination of foods plus Himalayan salt to reach that goal.
The Impact of Excessive Salt Intake on Certain Health Conditions
While moderate salt intake is vital for normal physiological functions, its excessive consumption can have detrimental effects, particularly for individuals with certain health conditions. For instance, endocrine disorders, high aldosterone levels, Cushing's syndrome, and elevated cortisol levels can all heighten the body's sensitivity to sodium, making it even more essential to monitor and limit salt intake.
Endocrine disorders, which involve imbalances in the body's hormone production, can often lead to increased sodium retention, exacerbating issues of water retention and swelling. Similarly, high aldosterone levels, a hormone that regulates sodium and potassium balance, can cause the body to retain excessive sodium, leading to high blood pressure and potential damage to the cardiovascular system.
Cushing's syndrome, a condition characterized by excessive cortisol production, can lead to a host of symptoms, including high blood pressure and rapid weight gain, both of which can be intensified by high sodium intake. The excessive cortisol found in Cushing's syndrome promotes sodium retention, further elevating the risk for hypertension.
Similarly, elevated cortisol levels, even outside of Cushing's syndrome, can lead to heightened sodium retention, contributing to high blood pressure, fluid retention, and an imbalance of electrolytes. Therefore, individuals with these conditions should be particularly mindful of their sodium intake.
In these scenarios, reducing salt consumption can help mitigate the associated health risks and symptoms. Switching to a diet rich in whole, unprocessed foods, and taking conscious steps to limit the use of added table salt can play a crucial role in managing these health conditions. As always, it is essential to seek personalized advice from a healthcare professional, as individual needs may vary.
In summary, while salt is often villainized in the health community, its consumption, especially from natural sources, is vital for maintaining bodily functions like nerve conduction, muscle contraction, and fluid balance. However, excessive or inadequate sodium intake can have adverse health effects, such as hypertension, imbalances in cholesterol and triglycerides, and even hyponatremia in severe cases. Certain health conditions, including endocrine disorders, high aldosterone levels, Cushing's syndrome, and elevated cortisol levels, can also exacerbate these risks, making it crucial for individuals with these conditions to carefully monitor their salt intake. On the other hand, increasing potassium intake can help maintain an optimal sodium-potassium balance, reducing blood pressure and lowering the risk of cardiovascular diseases. In a nutshell, moderation and balance are key in sodium consumption, but the emphasis should be on consuming more potassium-rich foods to ensure your potassium intake is higher than sodium levels which will ensure a healthier dietary approach.
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Date:
November 02, 2022 03:01 PM
Magnesium is a mineral that is critical for energy production, muscle contraction, nerve impulse transmission, and bone mineralization. It is a required cofactor for an estimated 300 enzymes. Among the reactions catalyzed by these enzymes are fatty acid synthesis, protein synthesis, and glucose metabolism. Magnesium status is also important for regulation of calcium balance through its effects on the parathyroid gland.
Magnesium oxide is a popular supplement because it is easily absorbed and bioavailable.* It features magnesium in its purest form and provides support for energy production.* In addition, magnesium oxide is essential for enzyme function* and helps to maintain healthy bones.*
What are the benefits of magnesium oxide?
Magnesium oxide is easily absorbed and bioavailable. This makes it an ideal supplement for those who want to increase their magnesium intake.* It features magnesium in its purest form and provides support for energy production.* In addition, magnesium oxide is essential for enzyme function* and helps to maintain healthy bones.*
How does magnesium oxide work?
Magnesium oxide works by providing your body with magnesium in a highly bioavailable form. This means that your body can easily absorb and use the magnesium for various functions.* Among these functions are energy production, protein synthesis, and regulation of calcium levels in the blood.*
Who should take magnesium oxide?
Anyone who wants to increase their magnesium intake can benefit from taking magnesium oxide. This includes people who are interested in supporting their energy levels*, maintaining healthy bones*, or ensuring proper enzyme function*. Talk to your healthcare provider if you have any questions about whether magnesium oxide is right for you.
Magnesium oxide is a popular supplement because it is easily absorbed and bioavailable. It features magnesium in its purest form and provides support for energy production. In addition, magnesium oxide is essential for enzyme function and helps to maintain healthy bones.
[*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.]
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Date:
October 31, 2022 05:02 PM
You may not have realized it, but magnesium is an essential mineral for your body. It aids in energy production and metabolism, muscle contraction, nerve impulse transmission, and bone mineralization. Magnesium is also a required cofactor for an estimated 300 enzymes. That means it helps catalyze reactions like fatty acid synthesis, protein synthesis, and glucose metabolism. Not to mention, magnesium status is also important for regulation of calcium balance through its effects on the parathyroid gland. Whew! As you can see, this mineral is pretty important stuff. Read on to learn more about why magnesium is so critical for our health.
Magnesium and Energy Production
One of the most important functions of magnesium is that it helps us produce energy. Every single cell in our bodies need energy to function properly, and magnesium plays a key role in the process of converting the food we eat into that much-needed energy. For example, magnesium is involved in breaking down carbohydrates into glucose which can then be used for energy by the cells.
Magnesium and Muscle Functioning
In addition to helping produce energy, magnesium is also necessary for proper muscle functioning. This mineral helps muscles relax after they contract as well as regulates electrolyte balance in the body. electrolyte imbalance can lead to muscle cramping, spasms, or even irregular heartbeats, so it's crucial that we maintain healthy levels of magnesium to keep our muscles functioning properly.
How to Get More Magnesium
Now that you know all of the important functions that magnesium plays in our bodies, you're probably wondering how you can make sure you're getting enough of this essential mineral. The best way to ensure adequate magnesium intake is through diet since our bodies cannot produce this mineral on their own. Some good dietary sources of magnesium include leafy green vegetables, legumes, nuts and seeds, whole grains, dairy products, fish, and meat. You can also get your recommended daily intake of magnesium through supplements if you feel like your diet is lacking or if you have a medical condition that requires extra magnesium (such as diabetes).
As you can see, magnesium is an essential mineral with many vital functions in our bodies. from helping produce energy to regulating electrolyte balance, this nutrient plays a big role in keeping us healthy and function properly both physically and mentally. Make sure you are getting enough magnesium in your diet by consuming foods like leafy greens, legumes, whole grains, dairy products ,and nuts or by taking supplements if necessary. Your body will thank you!
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Date:
May 11, 2022 12:19 PM
Did you know that melatonin is a powerful free radical scavenger? This means that it helps protect the body from damage caused by harmful molecules called radicals. Melatonin is also naturally produced in the pineal gland and is present in high amounts in the GI tract. We will discuss some of the ways that melatonin supports health and wellness.
Melatonin and the body
Melatonin is a hormone that is produced by the pineal gland in the brain. It is responsible for regulating the body's internal clock, or circadian rhythm. The production of melatonin increases at night, and decreases during the day. This hormone is also available in supplement form, and is often used to treat jet lag or insomnia. When taken as a supplement, melatonin works by resetting the body's internal clock, making it easier to fall asleep and stay asleep. Additionally, melatonin may also help to reduce anxiety and improve mood. As a result, this hormone plays an important role in regulating the body's sleep-wake cycle.
How does melatonin support a healthy sleep cycle?
Melatonin is a hormone that help regulate the sleep cycle. The production of melatonin is stimulated by darkness and inhibited by light. As a result, melatonin levels typically start to rise in the evening as the sun sets, and they remain high throughout the night. In the morning, light exposure causes melatonin levels to drop, helping to wake us up and start the day. Melatonin supplements can be used to help people who have difficulty sleeping and staying asleep. This hormone helps to reset the body's natural sleep cycle, making it easier to fall asleep and stay asleep. As a result, melatonin can be an effective way to support a healthy sleep cycle.
What are some of the other benefits of melatonin?
It can help to boost the immune system, protect against cancer, and reduce inflammation. Research suggests that melatonin may also have neuroprotective effects and could be beneficial for people with Alzheimer's disease or Parkinson's disease.
Tips for getting a good night's sleep
Most people need about seven to eight hours of sleep a day. However, many people find it difficult to get enough rest. There are a number of things you can do to improve your sleep habits. First, create a regular sleep schedule and stick to it as much as possible. Go to bed and wake up at the same time each day, even on weekends. Second, create a relaxing bedtime routine. This might include taking a warm shower, reading a book, or writing in a journal. Third, create a comfortable sleep environment by making sure your bedroom is dark, quiet, and cool. Fourth, avoid caffeine and alcohol before bed. Caffeine can make it difficult to fall asleep and stay asleep, while alcohol can disrupt your sleep cycle. Finally, try not to use electronic devices in bed. The blue light emitted by screens can interfere with your body's natural sleep rhythm and take melatonin. By following these tips, you can improve your chances of getting a good night's sleep.
Scientific research
Research on melatonin began in the 1950s, and since then, numerous studies have been conducted on its potential health benefits. Some of the most promising research has found that melatonin may help to prevent cancer. In one study, melatonin supplements were found to reduce the risk of breast cancer recurrence by half. Other research has shown that melatonin may help to protect against colon cancer, prostate cancer, and ovarian cancer. Additionally, melatonin has been shown to boost the effectiveness of chemotherapy drugs and radiation therapy.
While more research is needed to confirm the exact role of melatonin in cancer prevention, the available evidence suggests that it could play a significant role in protecting against this disease. Therefore, it may be worth considering supplementing with melatonin if you are at high risk for cancer or are undergoing treatment for this disease.
References:
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Date:
May 07, 2022 11:38 AM
Do you feel like stress is constantly wearing you down? It's no wonder, with all the demands on our time and energy. The good news is that there are steps you can take to reduce cortisol and improve your resilience. One of the most important is to make sure you're getting enough of the nutrients your body needs to stay strong. A cortisol balancing supplement can help make up for any deficiencies and give your body the support it needs to reduce cortisol levels and fight the effects of stress.
If you can balance cortisol levels you will have more energy & stamina, be able to manage weight better, boost immunity, support hormone activity, manage blood sugar better, reduce stress and improve mood.
The problem of cortisol imbalance and its effects on the body
The hormone cortisol is important for many bodily functions, including maintaining blood pressure and regulating metabolism. However, when the body experiences chronic stress, it can produce too much cortisol, leading to a condition known as "cortisol imbalance." Cortisol imbalance can have a number of harmful effects, including weight gain, anxiety, and depression. In extreme cases, it can even lead to adrenal fatigue. Unfortunately, cortisol imbalance is becoming increasingly common in our fast-paced, high-stress world. If you are concerned that you may be suffering from this condition, a supplement formulated to combat stress and high cortisol levels my be what you need. With proper nutrients, it is possible to restore balance to your hormones and improve your overall health.
The importance of nutrients in maintaining a healthy balance of cortisol
A healthy diet is important for many reasons. It can provide the body with the nutrients it needs to function properly, help to regulate hormone levels, and promote a sense of well-being. Cortisol is a hormone that plays an important role in the body's stress response. When levels of cortisol are too high, it can lead to anxiety, irritability, and difficulty sleeping. Eating foods that are rich in nutrients such as vitamin C, Vitamin B1, B2, B6, B12, Folate, Biotin, pantothenic acid, and DHEA can help to maintain a healthy balance of cortisol in the body. In addition, avoiding processed foods and managing stress levels with exercise can also help to keep cortisol levels in check.
Adrenal fatigue
Stress is a natural physical and mental response to the demands of life. It is the body's way of preparing to meet a challenge. However, when a person experiences chronic or long-term stress, it can take a toll on their health. Long-term stress can lead to a condition known as adrenal fatigue. This occurs when the adrenal glands become unable to produce adequate amounts of the hormone adrenaline. Cortisol is essential for managing stress and maintaining proper metabolism. When levels are too low, it can cause a variety of symptoms, including fatigue, difficulty concentrating, and difficulty sleeping. In severe cases, adrenal fatigue can also cause depression and anxiety.
Adrenal Fatigue and Adrenaplex
The adrenal glands are small, but they play a big role in our bodies. When the adrenal glands become fatigued, it can lead to a number of symptoms, including fatigue, trouble sleeping, mood swings, and low blood pressure. While adrenal fatigue is not a diagnosable condition, it is a real phenomenon that can be treated with lifestyle changes and natural supplements. Adrenaplex is one such supplement. This formula contains adaptogenic herbs that help to support the adrenal glands and improve their ability to respond to stress.
When Cortisol levels Are balanced You Will Experience:
Though it is possible to treat adrenal fatigue with a cortisol balancing supplement, the best way to prevent it from happening in the first place is by managing stress levels and eating a healthy diet. If you are under a lot of stress, consider adding an adrenal support supplement to your routine. This can help to improve your body's response to stress and keep your hormones in balance.
If you are looking for a way to reduce cortisol and the effects of stress, try a cortisol balancing supplement. These supplements help the body reduce cortisol and fight the effects of stress. With proper nutrients, it is possible to restore balance to your hormones and improve your overall health. Try a cortisol balancing supplement today! You may be surprised at how much better you will sleep, wake in the morning, and feel overall!
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Date:
April 30, 2022 09:39 AM
What is inflammation and what causes it?
Inflammation is a natural process that helps the body heal. It occurs when the immune system responds to an injury or infection. The symptoms of inflammation include redness, swelling, and pain. While inflammation is a necessary part of the healing process, chronic inflammation can lead to serious health problems. Chronic inflammation is often caused by lifestyle factors, such as smoking, obesity, and stress. dietary factors can also contribute to chronic inflammation, including a diet high in sugar. Sugar causes the body to release inflammatory chemicals that can damage tissues and lead to disease. Therefore, reducing sugar intake can help to reduce the risk of chronic inflammation.
What are the symptoms of inflammation?
Inflammation is a natural process in the body that helps to protect us from injury and illness. It occurs when the immune system detects harmful stimuli, such as pathogens or damaged tissue, and triggers a series of reactions which boost the production of white blood cells. However, if inflammation becomes excessive or chronic, it can cause a range of physical symptoms, including redness and swelling at the site of inflammation, increased pain sensitivity, headache, fatigue and fever. Other common symptoms include irritation in the eyes and mouth, digestive issues like diarrhea and nausea, rashes or skin lesions, changes in appetite and mood swings. If you are experiencing any of these symptoms on a regular basis, it is important to take anti-inflammatory supplements to help control inflammation. One such supplement is curcumin.
How can curcumin help to reduce inflammation in the body?
Curcumin is a compound that can be found in turmeric, a bright yellow spice commonly used in cooking. This powerful phytochemical has been shown to have potent anti-inflammatory properties, and can help to reduce inflammation throughout the body. One of the main ways that curcumin achieves this effect is by blocking an enzyme known as cyclooxygenase, or COX. This enzyme is responsible for producing pro-inflammatory compounds called prostaglandins that are often associated with pain and swelling. By preventing their production, curcumin can help to control acute and chronic inflammation in the body, thereby reducing the risk of conditions such as arthritis, heart disease, and cancer. In addition to blocking COX activity, curcumin helps to reduce oxidative stress by inducing production of antioxidants like superoxide dismutase. Overall, these mechanisms make curcumin an excellent natural treatment for chronic inflammation and a host of related health problems.
How to add curcumin to your diet?
Adding curcumin to your diet is a great way to reap the many health benefits of this powerful natural compound. There are several different ways that you can incorporate more curcumin into your daily routine, from simply adding it to your favorite recipes to taking a supplement. For example, you can start off by incorporating turmeric into your cooking, as turmeric is one of the richest sources of curcumin in nature. Additionally, there are many curcumin supplements available on the market that can be easily incorporated into your daily routine. Ultimately, by making these simple changes in your diet, you can enjoy all the great benefits of curcumin for overall health and well-being.
The benefits of taking curcumin regularly
Curcumin is a compound found in the spice turmeric. It has powerful anti-inflammatory and antioxidant effects, and it has been used for centuries in traditional Chinese and Indian medicine. Recently, curcumin has begun to gain recognition in the Western world as well. A growing body of research suggests that curcumin may have a wide range of health benefits, including the ability to improve cognitive function, reduce inflammation, and even ward off cancer. Curcumin is generally well tolerated, but it can interact with certain medications. However, for many people, taking curcumin regularly can be a safe and effective way to improve overall health.
To fight inflammation, reduce sugar consumption and take curcumin
To help reduce inflammation in the body, it is important to reduce your sugar intake and take curcumin supplements. These steps are vital because chronic inflammation has been linked to a wide range of health conditions, such as heart disease, diabetes, and even cancer. Additionally, sugar consumption can also worsen inflammation by triggering the release of inflammatory chemicals like cytokines and free radicals.
One of the best ways to fight against inflammation is to take curcumin supplements on a regular basis. Curcumin is a natural anti-inflammatory agent found in turmeric, a spice that is commonly used in Indian cooking. Research has shown that curcumin can be just as effective as anti-inflammatory drugs in reducing levels of tumor necrosis factor alpha (TNF-alpha), a potent inflammatory chemical released by cells. Furthermore, studies have also shown that taking curcumin regularly may benefit overall health and prevent certain age-related diseases like Alzheimer's.
Overall, reducing your sugar intake and taking curcumin supplements are two effective ways to fight inflammation and improve overall health. By following these simple steps, you can help protect yourself from the many negative effects of chronic inflammation.
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Date:
April 23, 2022 11:49 AM
Did you know that pancreatic cancer is the 4th leading cause of cancer-related death in the United States? It's a terrible disease, and unfortunately, it is often diagnosed too late for effective treatment. But what if there was something you could do to reduce your risk of developing pancreatic cancer? Believe it or not, there may be! A recent Chinese study has shown a clear correlation between higher intake of vitamins and lower risk of pancreatic cancer. The researchers believe that the vitamins induce apoptosis in cancer cells, thus preventing them from growing and spreading. So if you're looking for ways to improve your health, start by adding some vitamins to your diet!
What is pancreatic cancer?
Pancreatic cancer is a type of cancer that starts in the pancreas. The pancreas is a gland located in the abdomen behind the stomach. It produces enzymes that help with digestion and hormones that help regulate blood sugar levels. Pancreatic cancer usually starts in the cells that line the ducts of the pancreas. These cells are called pancreatic adenocarcinoma cells. Less commonly, pancreatic cancer can start in the hormone-producing cells or the enzyme-producing cells of the pancreas. Pancreatic cancer is a rare form of cancer, but it is one of the most deadly. The American Cancer Society estimates that approximately 56,770 people will be diagnosed with pancreatic cancer in 2018 and that approximately 45,750 people will die from the disease. There are several risk factors for pancreatic cancer, including smoking, obesity, diabetes, and family history. There is no sure way to prevent pancreatic cancer, but maintaining a healthy lifestyle may lower your risk. If you are diagnosed with pancreatic cancer, treatment options may include surgery, radiation therapy, chemotherapy, and targeted therapy. Clinical trials are also an option for some patients.
Did you know that pancreatic cancer is the fourth leading cause of cancer-related death in the United States? It's a terrible disease, and unfortunately, it is often diagnosed too late for effective treatment. But what if there was something you could do to reduce your risk of developing pancreatic cancer? Believe it or not, there may be! A recent Chinese study has shown a clear correlation between higher intake of vitamins and lower risk of pancreatic cancer. The researchers believe that the vitamins induce apoptosis in cancer cells, thus preventing them from growing and spreading. So if you're looking for ways to improve your health, start by adding some vitamins to your diet!
There are many different types of vitamins, and it can be confusing to know which ones you should take. However, the study's findings suggest that vitamin C, vitamin E, and beta-carotene are particularly effective in reducing the risk of pancreatic cancer. You can find these vitamins in many different foods, or you can take them in supplement form.
Getting more vitamins is just one part of a healthy lifestyle that can help reduce your risk of cancer. Eating a balanced diet and getting regular exercise are also important. And if you're looking for ways to improve your health, adding some vitamins to your diet is a great place to start!
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Date:
February 17, 2020 04:39 PM
People need effective immune support every day. ViraPro can make all the difference by providing key immune vitamins and minerals well known for their effectiveness, along with clinically studied Haschberg Austrian Elderberry, freeze-dried to preserve all the beneficial nutrients from the entire berry, to support a healthy immune system.*
Whether your customers need daily proactive support or extra nutrients for an effetive, 7-day regimen, ViraPro provides an elderberry immune blend for optimal benefits.*
ViraPro's elderberry immune blend:
ViraPro is a great supplement to support a healthy immune response especially in the winter months when sickness is the worst!.
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Date:
April 27, 2019 10:03 AM
Adding seaweed to your diet can help protect your system from becoming vulnerable to several ailments, while also lessening the amount of symptoms from chronic conditions that you have already been diagnosed with. Seaweed is known to promote proper thyroid functioning, helping protect your body from being diagnosed with over or under-active thyroid disease. If you are living with diabetes, the consumption of seaweed can help reduce the effects of insulin resistance and inflammation that you may experience. Key Takeaways: "Research on seaweed shows its numerous benefits for the digestive system, thyroid glands, and the general health." Read more: https://tophealthjournal.com/4369/why-should-you-add-seaweed-to-your-diet/
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Date:
April 19, 2019 02:33 PM
Traditionally, melatonin supplements have been taken to induce a full night's rest, as well as aiding individuals in easing into a deep slumber. Since melatonin is a natural angiogenesis inhibitor, it actually has the ability to reduce the significance of tumors that are located within the body. The process of inhibiting angiogenesis is an essential part of treating cancer patients because it helps target the cells with oxygen. This helps regulate cell migration as well as invasion. Key Takeaways: "A team of researchers from Iran suggests that melatonin has powerful anticancer properties." Read more: https://www.naturalnews.com/2019-02-27-why-melatonin-is-a-powerful-anticancer-indolamine.html
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Date:
March 23, 2019 10:59 AM
Cannabis sativa, otherwise known as marijuana, has been used as a natural medicine for thousands of years, prior to the development of western civilization. However, with the introduction of synthetic pharmaceutical drugs, governments deemed marijuana as evil and dangerous. By the 1930s, the U.S., England, and Canada all outlawed marijuana. However, over the last twenty years, there has been an overwhelming amount of cannabis research out of Spain, Israel, and Brazil, uncovering the human body’s endocannabinoid system and identifying marijuana as the new powerhouse drug of this century. Key Takeaways: "By making cannabis “illegal,” governments of the West paved the way for Big Pharma to take over and declare its poisons as the only safe and effective medicine out there – “medicine” that, in some cases, was derived and synthesized from the very same cannabis plant that, under Schedule I designation, was deemed to have no legitimate medical use." Read more: https://www.naturalnews.com/2019-01-20-medical-benefits-of-cannabis-suppressed.html
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Date:
February 20, 2019 01:17 PM
The thyroid, a small gland at the base of the neck, receives TSH from the pituitary gland. This relationship, whether too active or not active enough, causes many adverse side effects. Too much TSH (hyperthyroidism) can cause: weight loss, cardiovascular irregularities, nervousness, and etc. Too little TSH (hypothyroidism) causes symptoms like: depression, impaired memory, hoarseness, fatigue, weight gain, etc. Currently, no cure exists for either of these conditions, other than individual specific diets targeted at raising or lower TSH levels. As always, one should consult a doctor and get proper blood work done before making any major life changes. Key Takeaways: "Thyroid problems can affect anyone of any age from infancy to the latest years of life." Read more: https://draxe.com/hyperthyroidism-vs-hypothyroidism/
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Date:
February 12, 2019 10:20 AM
Probiotics help boost or maintain good gut flora and bacteria. A collaboration of 12 studies around the world have found that infants and small kids may benefit more from probiotics than first thought, when treatment for certain illnesses has been traditionally antibiotics. Antibiotics kill off the good and bad bacteria in ones system, and because of their limited diet, ( foods they can or will eat) replenishing that vital flora can be difficult, resulting in prolongation of condition or a greater risk of a secondary infection due to lowered immune response. Key Takeaways: "However, data from a review has determined that probiotics can also be used to reduce the need for antibiotics among infants and children." Read more: https://www.naturalnews.com/2019-01-04-probiotics-reduce-the-need-for-antibiotics.html
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Date:
January 11, 2019 01:49 PM
High impact and strenuous training or lifestyle takes its toll on the body. One area that has a highly impacted rate of declined performance is that of the immune system. Lower immune system function can happen not only with the physical stress of training , work outs or lifestyle, but mental stress as well. Chorella is a micro marine algae that has several minerals and vitamins that help to repair the system as well as act as a detoxification vehicle. Key Takeaways: "Researchers in England aimed to evaluate the effects of chlorella supplementation on salivary sIgA in response to a two-day intensive training exercise." Read more: https://www.naturalnews.com/2018-12-27-supplementing-with-chlorella-can-hasten-recovery-from-intense-training-and-exercise.html
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Date:
September 02, 2018 05:53 PM
In today's day and age, many people are going through a phase of where they want to eat very healthy and are willing to go to a very far extent to ensure that they stick to a diet. Now, there are things like Indian olive which is considered to be a super food. Of course there is acai and most people know what that is. However, Indian olive is a new one that has been received well by many. Key Takeaways: "For the study, the researchers looked at the phenolic contents, antimicrobial, and antioxidant activities of the olive plant. They used three crude extracts of the leaf and bark extracts of the olive tree: chloroform, ethanol, and methanol extracts." Read more: https://www.naturalnews.com/2018-08-30-why-the-indian-olive-is-one-of-the-best-superfoods.html
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Date:
August 03, 2018 09:53 AM
Pecans originate from the Midwestern part of the US, and their health benefits are shown to be quite substantial. Pecans are high in vitamin E, which causes them to have large amounts of antioxidants properties. They can also help clean and regulate oxidation processes in order to help contribute to the prevention of various cancers. Studies have indicated that consumption of pecans may also have the ability to help those with liver damage, but it has not been proven in human subjects as of right now. Key Takeaways: "Referred to as Carya illinoinensis in scientific literature, pecans are a member of the Juglandaceae family, which makes it a relative of the hickory and the walnut. Pecans are also considered native to North America; their existence has predated even the earliest human settlements." Read more: https://www.naturalnews.com/2018-06-11-the-health-benefits-of-eating-pecans.html
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Date:
July 22, 2018 11:53 AM
The human body has a well-developed system it uses to aid us when we experience stress. Firstly, the brain identifies the threat. Then the body releases hormones designed to do two things, rush blood to the muscles and heart to assist in fighting off the aggressive agent and dampening body processes that are not needed in the attack, such as digestive ones.
Were one fighting of a saber-tooth tiger, this would be of benefit. Today's stresses are far more nuanced, insidious and long-lasting. And when constant stress overworks the adrenals, which are the rabble-rousers in charge of turning off immunity and digestion until the tiger has turned tail, well then they get tired. This condition is called, aptly, adrenal fatigue. It can last for a short while, or a long time. It induces fatigue and it can lead to "brain fog." Other symptoms can include disturbances in mood, or sleep, food cravings and muscle and bone loss. To recuperate, it's necessary to convince the body the tiger has gone. Eat healthy, sleep healthy. Take vitamins and nourish yourself physically and psychically. Key Takeaways: "One of the most important parts of restoring adrenal function is listening to your body and minding your stress levels." Read more: https://www.healthnutnews.com/overcoming-adrenal-fatigue-naturally/
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Date:
February 07, 2018 03:59 PM
St. John’s wort A scientific of this remarkable antibacterial and antioxidant properties study was from African but how some bacteria affect some crops that man nee for consumption and this is the bacteria strains which cause mastitis[ this happens when breast tissue is infected.], and also create problems for the mammary glands in terms of inflammation. Overall, researchers found out the H. perforatum extract contained significant antibacterial properties, which could have potential pharmacological uses — particularly in plant-based medicine. Key Takeaways: "While it exhibited antioxidant property, the research team posited that the plant’s ability to counter cell mutation opens the door to further research." Read more: https://www.naturalnews.com/2018-02-05-st-johns-wort-a-scientific-review-of-the-antibacterial-and-antioxidant-properties.html
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Date:
September 03, 2017 12:14 PM
You can mix only three ingredients together and get rid of body odor almost instantly. There are many deodorants on the market that help us fight sweat, but many of them do not meet our expectations, or give us what we need. Creating your own natural deodorant is a great thing to try. You will need some baking soda and corn starch and coconut oil as well. You will need to mix the ingredients together. Key Takeaways: "Few knows that antiperspirants contain a substance that clogs the sweat glands disrupting their normal functioning."
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Date:
September 01, 2017 12:14 PM
Serotonin helps regulate body temperature, mood, sleeping patterns and aids in digestion, among other benefits. It's common for those that have low levels of serotonin to experience depression and many antidepressant medications raise serotonin levels to combat depression. If you want to raise your serotonin levels naturally(or tryptophan a serotonin precursor), without the side effects involved with prescription medications, you may want to try adding these foods to your diet. They include frits, vegetable, eggs, meats and even chocolate Key Takeaways: "Serotonin plays an important role in controlling our circadian rhythms - our body’s internal clock." Read more: https://www.healthambition.com/foods-boost-serotonin/
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Date:
August 25, 2017 09:14 AM
A recent study conducted at the University of Nottingham in England has shown that a single dose of Cannabidiol can effectively lower blood pressure for individuals that are suffering from high blood pressure. This is great news, considering Cannabidiol is a non-addictive, natural medication. It is also an amazing breakthrough because this means that it can treat many other cardiovascular disorders, not just hypertension. Cannabidiol is believed to be a neuroprotectant that can help prevent cardiovascular disease and stroke, in addition to lowering an elevated heart rate. Key Takeaways: "Nearly 75 million adults in the United States suffer from hypertension, or high blood pressure. That means around 32 percent of the population is at an increased risk for heart disease and stroke. It’s very promising that CBD has the possibility of reducing and preventing certain cardiovascular disorders." Read more: http://www.cannatech.news/2017/08/21/single-dose-cbd-shown-reduce-blood-pressure/
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Date:
August 22, 2017 07:14 AM
Hypothyroidism occurs when the thyroid gland is performing at below the usual capacity due to a deficiency in the amount of thyroid hormone being produced by the body. When the thyroid is underactive, it leads to the underperformance of other important bodily processes. The thyroid gland needs sufficient levels of iodine in order to function properly. In addition, omega-3 fatty acids, selenium, pectin, and Vitamin D all help to ensure the successful operation of the thyroid as well. Read more: 'Vitamin D helps fight against hypothyroidism'
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Date:
August 11, 2017 12:14 PM
There is a natural treatment for your thyroid gland. There can be problems with your thyroid when it is overly active and produces too much thyroid hormone. Having a healthy thyroid is a very important thing. There are changes that you can make to your lifestyle and medications that you can use to make your thyroid healthy and keep it that way. Coriander seeds and water is a great meal to have for a healthy thyroid. Key Takeaways: "There are lifestyle changes and medications you can use to get and keep a healthy thyroid."
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Date:
August 03, 2017 05:14 AM
Thyroid problems are no fun. They can cause weight gain and more. There is a way to help it, though. Apparently you can eat raw onion. This doesn't have to be as unpleasant as it sounds at first. You can eat them in a salad. Many also eat them with vinegar and seasonings on them or on sandwiches. There are many ways. Onions are very good for you so should be part of your diet anyway. Key Takeaways: "It is known that onions clean the skin, kill bacteria, and the phosphoric acid enters the bloodstream and miraculously helps to purify the blood."
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Date:
July 25, 2017 04:14 PM
The question has been raised and it asks if we should be buying iodized salt. There have been tests done that have come to the conclusion that were are sufficient in the United States, when it comes to our iodine consumption. Most people from America get enough iodine, even if they do not use any iodized salt in their meals. They have a very small risk for having an iodine deficiency, which can lead to them getting goiters. Key Takeaways: "Most Americans who eat a varied diet get enough iodine even if they don’t use iodized salt. They are at little risk of iodine deficiency, which can lead to goiters (swollen thyroid glands in the neck) and dwarfism and is a leading cause of mental impairment worldwide." Read more: https://www.nytimes.com/2017/07/21/well/eat/should-we-be-buying-iodized-salt.html?partner=rss&emc=rss
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Date:
July 03, 2017 05:14 AM
If you have problems with the thyroid, it can affect your life in an abundance of ways. Detecting a thyroid problem isn't easy in some cases, however. But, could it be that a thermometer is the only item that you will nee to determine if there are thyroid issues affecting your life? The details that you find here are pretty amazing but very much true. Put this information to use and you will benefit tremendously. Key Takeaways: "This test is very simple and is known as Barney’s test. All you need is a thermometer."
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Date:
June 09, 2017 04:14 PM
Researchers in England have found that combining cannabis usage with chemotherapy improves the treatment's effectiveness against leukemia. The inclusion of the cannabis allows for lower dosages of chemotherapy to be used, limited the harsh effects of the treatment.
Researchers have found that application sequence is critical for effectiveness. the active chemicals from the cannabis should be administered after the chemotherapy treatment for best results.
While they stress the need for more testing before such treatment can become commonplace, it represents and exciting development on the cancer treatment front. Key Takeaways: "Scientists say the order the treatments are administered is crucial. Using cannabinoids after chemotherapy killed off blood cancer cells more rapidly." Read more: http://wqad.com/2017/06/07/cannabis-combined-with-chemotherapy-effectively-destroys-cancer-cells/
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Date:
April 26, 2017 04:59 AM
If you have an onion in the pantry, go grab it really quickly. Once you have the onion, place it on the back of your neck. It sounds odd and a very strange thing to do, but this is a habit of many people who want to resolve this disease. Putting that onion on your neck is something that you should do if you want to resolve this issue once and for all! It really works. Key Takeaways: "The problems with the thyroid gland are one of the most common ones of our time. These issues can seriously endanger the health condition of the entire body."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4479)
Date:
April 07, 2017 08:44 AM
Your thyroid is an important gland that releases hormones responsible for body growth and development. When it slows down, a condition called hypothyroidism, your body functions slow down too including your brain and gut function. Hypothyroidism can be diagnosed with a blood test but some people's levels are just out if range to be diagnosed with hypothyroidism, they still suffer from an under functioning thyroid. You should see your doctor if you have symptoms of hypothyroidism including dry puffy skin (a condition also caused by hyperthyroidism) , low energy., constant constipation or diarrhea and weight fluctuations. Hyperthyroidism can cause quick weight loss while hypothyroidism and drop your metabolic rate causing weight gain.. Eliminating sugars and increasing protein intake can also help thyroid function . Key Takeaways: "approximately 200 million people across the globe suffer from some type of thyroid dysfunction." Read more: http://www.thealternativedaily.com/signs-your-thyroid-is-making-you-sick/
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Date:
March 16, 2017 11:59 AM
If you are not feeling up to your old self and find that you are stressed and anxious, perhaps it is time to look at the foods that you are consuming. If you are not eating a healthy, well- balanced diet, your body suffers in many ways. New evidence suggests that consumption of certain foods lowers the risk of anxiety and helps boost your mood so you always feel at your best. These seven foods should be on your plate regularly. Key Takeaways: "Iodine is an important mineral that is required to keep the thyroid gland healthy. The thyroid gland controls almost every cell in the body by regulating metabolism so if we are lacking in iodine this can affect brain function, mood and concentration." Read more: http://rescu.com.au/what-food-will-help-lower-anxiety-and-boost-my-mood/
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Date:
February 23, 2017 07:59 AM
Seaweed is a common ingredient in Japanese cuisine. However, for the average American this mystical, slimy, spinach-like vegetable is something they only know from sushi rolls or miso soup. Many may not even know it is edible, let alone know how to prepare a meal with it. While it may not look very appetizing to you, this green, red, or brown sea vegetable is high in essential nutrients and packs a variety of health benefits including cancer prevention and protection from radiation or oxidative stress. Key Takeaways: "Red seaweed is a rich source of protein and various antioxidants, vitamins, minerals, trace elements, and other beneficial compounds not found in any other food." Reference:
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Date:
February 20, 2017 10:19 AM
For people that are losing their hair and have weak and brittle nails, there is a cure for you. Adrenal gland issues can effect these parts of your life. A homemade and natural recipe using Brazilian walnuts is the answer. You only need a few natural ingredients and you will be on your way to fixing these issues. Key Takeaways: "It may interest you to know that adrenal gland issues can affect the health of your hair, nails and even your sleep quality."
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Date:
February 13, 2017 02:59 PM
There are many remedies for dry eyes out there. This gives you some more ideas. Dry eyes can be very unpleasant. It can be anything from irritating to painful. It happens when the body doesn't make enough tears for themselves. Tears are needed to lubricate the eye's sensitive membranes and without them irritation occurs. Key Takeaways: "Taking care of dry eyes not only relieves discomfort but can help you avoid infection or even scarred corneas." Reference: //www.health.harvard.edu/blog/the-fix-for-dry-eyes-2017021011090
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Date:
February 11, 2017 02:59 PM
Based on evidence, it turns out that fish oil can help fight asthma. The omega 3 fatty acids found in fish oil can help to fight asthma. This is what a lot of scientists at universities are saying. There was a study published in the New England Journal of Medicine in December of 2016 that showed pregnant women, who ate fish, or took fish oil supplements had a lower risk of having kids with asthma. Key Takeaways: "Steroids are usually a very effective treatment for asthma." Reference:
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Date:
February 08, 2017 10:59 AM
Depression is a serious condition affecting millions of people around the world. While treatment options for depression is available, for many the condition is one they'll battle for the rest of their lives. Now, some researchers say that depression increases the odds that you'll die from cancer. Don't miss this important information. Key Takeaways: "Medical records of more than 160,000 adults in England and Wales showed that those describing themselves as psychologically distressed were more likely to succumb to cancer, especially of the colon, prostate and pancreas." Reference: https://www.yahoo.com/news/does-depression-boost-risk-cancer-death-100013257.html?ref=gs
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Date:
February 07, 2017 02:59 PM
You may have never heard of the mineral Selenium, but did you know it does wonders for our body? Selenium can be used for making electronic devices and some glass products but a small amount of this mineral can help keep our bodies healthy. Some people may have deficiency to the mineral which can cause many problems. You can find out more about selenium and how is works for us in this article Key Takeaways: "It is important to include selenium in an appropriate amount in the diet." Reference:
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Date:
January 15, 2017 07:59 AM
Are you one of many that are trying to watch their weight? Eating your favorite low calorie yogurt? Well watch out because some of your favorite yogurts could contain a high amount of sugar! The public health of England was drawing concerns about some yogurt brands containing high amounts of sugar. Key Takeaways: "Public Health England recently raised concerns about the huge amounts of sugar in some of our favourite flavoured yoghurt brands." Reference:
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Date:
December 22, 2016 10:59 AM
Hashimoto’s disease is a hypothyroid disorder that is caused by an immune attack on your thyroid. This leads to a generally fatigued and weak feeling that persists longer than expected. It can also affect the health of your hair, your weight, and how you respond to cold environments. So, if you have been feeling rundown for a while and just generally down in the dumps with any of the other above symptoms, it may be time to talk to your doctor to get tested. Key Takeaways: "Hashimoto’s is the most common autoimmune thyroid disorder. For a variety of reasons, your immune system sets out to attack your thyroid gland. Over time, the thyroid gland is slowly destroyed" Reference: //renegadehealth.com/blog/2016/12/02/5-sure-fire-ways-to-know-if-you-have-hashimotos
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Date:
December 07, 2016 02:59 PM
A new mechanism has been discovered that connects phosphatidyl choline (also called lecithin), a common dietary fat, along with intestinal microflora, to an increased risk of heart disease. The study shows that the heart risk of people with a diet high in the lipid depends on how the micro-organisms that live in their digestive tracts metabolize it. When lecithin and choline were fed to mice, the substances were converted to a heart disease-forming product by the intestinal microbes. In humans, higher blood levels of choline and the heart disease forming microorganism products are strongly associated with increased cardiovascular disease risk. Key Takeaways: "Finding Balance: Empower Yourself with Tools to Combat Stress and Illness,” discuss heart disease and stomach bugs, and how the bacteria in your gut affects your health." Reference:
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Date:
December 06, 2016 07:59 AM
Different areas of the world have different germs and it is easy to pick up a germ you are not resistant to already. No one wants to get sick when they travel and ruin their vacation or business trip. This article will explain five different ways to avoid picking up new germs while you travel. Key Takeaways: "Gendreau studies germiness while traveling, and he knows just how infectious travel can be." Reference:
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Date:
December 02, 2016 10:59 AM
Moderate physical activity lowers your chances of getting a heart attack by 30% to 50%. If you stick to a healthy diet you could lower your odds of getting heart disease by 25%. Fill your plate with different kinds of fruits, veggies, whole grains, fish, and lean meats. Stay away from processed or prepared foods that often are high in salt and filled with preservatives. Key Takeaways: "The study was discussed Sunday at an American Heart Association conference in New Orleans and published online in the New England Journal of Medicine." Reference:
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Date:
November 10, 2016 05:53 PM
Do you often feel run down and fatigued during the day? So tired you could sleep? Do you crave and use salty and sweet foods as well as caffeine to get you through the day?
If you answered yes to one or more of these questions it is likely that you may be suffering from Adrenal Fatigue or "Burnout." It's a very common problem which often goes unnoticed. It affects significantly more women than men. The number of people suffering has rocketed since the recession - money worries and job worries causing major stress.
Adrenal Fatigue is a term used to describe when the adrenal glands are exhausted. Adrenal fatigue is very commonly associated with stress levels. The adrenal glands release Cortisol in response to all stress, cortisol is your natural anti-inflammatory and reduces stress and inflammation levels when needed.
Your adrenal glands are located just above the kidneys and are the size of walnuts. They have a very important function within the body, they secrete over 50 different hormones which your body needs to survive. As well as cortisol some of the other hormones that the adrenal glands secrete include testosterone, estrogen, epinephrine, and progesterone.
People can live with this all their life and think it is just normal. This fatigue cannot simply be relieved by a good night's sleep. An estimated 80% of people at some point experience some form of adrenal fatigue and the physical symptoms associated with stress.
It is unlikely that a doctor will immediately diagnose you with adrenal fatigue, in my research I read about a female sufferer of adrenal fatigue who saw 27 different doctors before having her problem identified as adrenal fatigue! This is an extreme case.
Adrenal fatigue can really wreck the life you live, in extreme cases, it can be so bad that you are only able to stay awake and move around for a couple of hours a day. Changes are made in your carbohydrate, protein and fat metabolism, fluid and electrolyte balance is affected as well as your heart, cardiovascular system and sex drive as a result of adrenal fatigue.
The main symptoms of adrenal fatigue are:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3422) You Can Repair the Adrenal Glands with the Right Diet
Date:
November 09, 2016 01:32 AM
Bored with trips to the doctor or naturopath and the costs involved as you attempt to restore the functionality of your adrenal glands? If yes, then embrace an adrenal-supportive diet plan. Apart from reducing the costs you incur to treat adrenal fatigue; you will enjoy several other benefits that come with eating right. Basically you will have to take nutritious whole foods, eat at the right time, and avoid foods that you have intolerances to. Apart from the above, you will have to reduce stressing your mind and body, eliminate toxins and embrace positive thinking at all times. The details below will give you a proper guide towards your recovery.
The Adrenal Fatigue Diet
Since the problem is already here, you have to start by removing toxins and hard-to-digest foods from your diet (embrace a Paleo or Primal diet). This means you have to eliminate legumes, grains, vegetable oils, caffeine, microwaved and processed foods, and refined sugar.
After that, take foods that help replenish the energy of your adrenal glands. They include avocado, olives, Cruciferous vegetables, coconut, Fatty fish, turkey and chicken, seeds (like flax, chia and pumpkin), seaweed and kelp, Himalayan or Celtic sea salt, nuts (like almonds and walnuts), and food fats. These foods have low sugar levels, they are nutrient-dense, and contain healthy fiber and fat.
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Do you suffer from inflammation? If so, you're not alone. Inflammation is a common problem that can cause pain and discomfort in the body. Fortunately, there is a natural remedy that can help: curcumin. Curcumin is a compound found in turmeric that has powerful anti-inflammatory properties. We will discuss the benefits of curcumin and how to add it to your diet. 
What is Trace Minerals
What is thyroid glands.jpg )
Importance of selenium
Introduction:
Healthful supplements
Rarely do people bank on herbs for treatment. Chemically manufacture medicines have taken over. However, what makes Boswellia herb very important? This herb has been used for a very long time. It is extracted from the Boswellia serrate tree. This herb is popular among other pharmacological medicines because of its medicinal values of reducing the effect of inflammation and inflammation related diseases. 
Ylang ylang oil has many health benefits. We can draw some of its benefits from its characteristics, like for instance hypertensive, sedative and antidepressant substance. Ylang ylang has gained worldwide recognition over the recent years due to the production of hundreds of cosmetic products that have this essential oil.
Germanium oil is known to be very beneficial to the body and has been used to treat and prevent various diseases. It is a major material in cosmetics industries due to it soothing ability. 
Parabens are artificial preservatives used in many domestic manufacturing industries especially for cosmetics, food and drugs industries. Most manufactures prefer Parabens because they are cost effective and are also efficient in protection against micro-organisms for long time. 
Pumpkin seeds have been gaining traction around health circles in recent months and all for the right reasons. These greenish flat-shelled seeds that pumpkin lovers have been throwing away for years have been proven through tests to contain a whole lot of nutrients.
Majority, if not all of the non-organic elements or minerals are present in the human body. Some are vital in our diet and can be derived from the food that we eat. Minerals are categorized into macro/major minerals and the micro/trace minerals. 
Are popular amino acids among individuals who are enthusiastic about athletic performance and muscle development. L-Arginine and L-Citrulline are marketed as amino acid supplements that are especially useful for athletes who need an additional biochemical support for enhanced muscular energy and growth of muscle fibers. Bodybuilders and weightlifters are especially passionate about amino acid supplements because it helps them break through muscle development stagnation and reach more difficult goals in terms of muscle size or weight lifting potential.
Acerola:
What is Iodine
What is GABA
What is Colustrum
Benefit of Maca root. 
