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NSAIDs vs. Curcumin: Which One Relieves Joint Pain Without Stopping Healing?   
Date:
September 14, 2026 11:22 AM
Comparative Analysis of NSAIDs versus Curcumin in Musculoskeletal Tissue RepairPrimary Biological Mechanisms and Pharmacological TargetsManaging soft tissue and joint injuries presents a persistent therapeutic challenge in musculoskeletal medicine. Acute inflammation triggers pain, localized swelling, and mechanical disability, which routinely drives patients toward pharmacological relief. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, celecoxib, and diclofenac have served as primary clinical interventions. While these synthetic agents effectively extinguish acute pain signals, expanding cellular and clinical research indicates that their biochemical mechanism interrupts the fundamental repair cascades required for long-term connective tissue healing. In contrast, curcumin - a natural polyphenolic compound derived from the rhizomes of Curcuma longa (turmeric) - exhibits a distinct, multi-targeted regulatory profile that calms hyperactive inflammation while protecting the structural components of cartilage and tendon tissue.The functional divergence between these two compounds becomes clear when considering an intuitive mechanical analogy. Tissue trauma resembles damage to a commercial building, where initial inflammation functions as the construction and demolition crew tasked with clearing rubble, stabilizing the foundation, and laying down fresh structural framing. NSAIDs function like abruptly cutting electrical power to the entire work site: the noisy machinery stops instantly and the immediate disturbance ceases, but the construction workers lose the power necessary to clean the debris and erect permanent walls. Conversely, curcumin operates as an experienced site manager: it silences unnecessary chaos and prevents site vandalism while ensuring that the skilled workers - specifically chondrocytes in cartilage and tenocytes in tendons - remain fully active, supplied, and capable of completing the restoration. At the cellular level, NSAIDs exert their effects through the catalytic inhibition of cyclooxygenase enzymes, categorized as constitutive cyclooxygenase-1 (COX-1) and inducible cyclooxygenase-2 (COX-2). Membrane phospholipids damaged during injury release arachidonic acid, which COX enzymes convert into pro-inflammatory lipid mediators known as prostanoids, most notably prostaglandin E2 (PGE2). Nonselective NSAIDs block both isoforms, while selective coxibs specifically target COX-2. By shutting off PGE2 production, NSAIDs rapidly elevate pain thresholds and blunt localized swelling. However, because PGE2 also functions as a vital signaling cue for cellular recruitment, angiogenesis, and cellular proliferation, this total enzymatic shutdown strips local repair cells of the baseline signals required to orchestrate tissue regeneration. Curcumin avoids this indiscriminate pathway paralysis by acting upstream on master transcriptional control switches rather than directly neutralizing isolated enzymes. Its primary therapeutic mechanism centers on the inhibition of Nuclear Factor-kappa B (NF-kB) and Activator Protein-1 (AP-1) signaling networks. Under acute stress or chronic inflammatory loads, the NF-kB protein complex is released from its cytoplasmic inhibitor, IkBa, and translocates directly into the cell nucleus, where it drives the transcription of catabolic cytokines such as interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-a), and interleukin-6 (IL-6). Curcumin blocks the phosphorylation and degradation of IkBa, effectively keeping NF-kB trapped in the cytoplasm. By preventing this nuclear entry, curcumin attenuates the expression of pro-inflammatory cytokines and downstream matrix-degrading enzymes while preserving baseline physiological functions. Furthermore, curcumin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) pathways, which upregulate endogenous cellular antioxidants to neutralize destructive reactive oxygen species (ROS) that induce cell death in injured joints.
The Mechanisms of NSAID-Induced Inhibition in Cartilage and Tendon RepairArticular cartilage and tendons are specialized, bradytrophic connective tissues characterized by relatively low basal metabolic rates and limited endogenous vascular supplies. These physical constraints make their cellular maintenance highly vulnerable to pharmaceutical disruptions. When synthetic compounds impair cell migration, survival, or extracellular matrix secretion, the intrinsic repair capacity of these structures is substantially degraded.Cartilage maintenance depends on chondrocytes, the sole cell type residing within articular joints, which are responsible for generating and maintaining the extracellular matrix of Type II collagen and water-binding proteoglycans such as aggrecan. Because adult articular cartilage lacks a direct vascular network, major defect repair relies heavily on the recruitment and chondrogenic differentiation of subchondral mesenchymal stem cells (MSCs) through endochondral ossification. Experimental evaluations demonstrate that systemic or intra-articular NSAID exposure halts this regenerative differentiation. Both nonselective NSAIDs and selective COX-2 inhibitors interfere with chondrocyte maturation and prevent successful tissue integration following cartilage transplantation or microfracture procedures. At the cellular level, common NSAIDs - including indomethacin, ketorolac, and diclofenac - induce cell cycle arrest in chondrocytes by blocking transition from the resting G0 phase to the proliferative G1. phase, substantially reducing viable cell numbers. Concurrently, NSAIDs downregulate Bone Morphogenetic Protein-2 (BMP-2), an essential anabolic signaling molecule that orchestrates matrix synthesis. Histological analyses in animal models reveal that NSAID administration causes a marked loss of extracellular proteoglycan content and widespread chondrocyte depletion, yielding elevated modified Mankin scores that signify advanced structural degeneration. In layman's terms, proteoglycans serve as water-absorbing structural sponges that grant cartilage its elastic shock absorption. When NSAIDs deplete these molecules, the joint surface dries out, becomes brittle, and rapidly wears down under routine mechanical friction. Tendon healing is similarly susceptible to disruption by NSAIDs. Tendons operate as high-tensile structural cables composed of longitudinally arranged Type I collagen fibers, maintained by specialized fibroblasts termed tenocytes and tenoblasts. Healing after acute rupture or chronic tear progresses through an initial inflammatory phase, followed by a proliferative phase of cell migration, and culminates in a lengthy remodeling phase of collagen alignment. In vitro and in vivo studies establish that NSAIDs directly suppress the migration and proliferative capacity of tenocytes during the critical early healing window. Without an adequate cellular workforce migrating into the wound bed, provisional collagen scaffolding cannot be synthesized effectively. The disruption is particularly pronounced at the enthesis, the specialized fibrocartilaginous junction where soft tendon inserts into rigid bone. Re-establishing this transition zone requires coordinated bone remodeling and chondrogenic differentiation, both of which are hindered by COX inhibition. In animal rotator cuff repair models, early administration of NSAIDs significantly delays collagen fiber organization and impairs mechanical integration at the insertion site, resulting in a measurable decline in load-to-failure strength and overall tendon toughness. Furthermore, while prolonged inflammation contributes to pathological degeneration, the transient synthesis of PGE2 during the initial hours following injury is essential for regulating localized microvascular flow and hyperemic nutrient delivery. By eliminating this early prostanoid pulse, NSAIDs starve the repair zone of oxygen and circulating factors precisely when the cellular metabolic demand is highest. Beyond direct biochemical cytotoxicity, systemic NSAIDs introduce a physical hazard known as analgesic arthropathy. In musculoskeletal biomechanics, pain functions as a protective feedback mechanism, forcing the patient to unload an injured joint or limb to prevent structural overload. By effectively blunting the pain reflex while simultaneously undermining the cellular synthesis of proteoglycans and collagen, NSAIDs create a deceptive state of perceived recovery. Patients prematurely resume unrestricted weight-bearing and strenuous activity, placing substantial, uncompensated mechanical forces onto compromised cartilage surfaces and unhealed tendon fibers. Over time, this recurring mechanical trauma accelerates joint space narrowing, promotes microfractures in the subchondral plate, and hastens functional joint breakdown. Chondroprotective and Tenogenic Mechanisms of CurcuminIn sharp contrast to the suppressive actions of synthetic COX inhibitors, curcumin exhibits a tissue-sparing, pro-regenerative biological profile. Rather than paralyzing cellular metabolism, curcumin modulates the microenvironment by suppressing destructive catabolic enzymes while supporting the baseline anabolic signals required for cartilage and tendon reconstruction.In articular cartilage, curcumin acts as a direct chondroprotective agent by dismantling the catabolic cascade induced by pro-inflammatory cytokines. When joint tissues are exposed to elevated IL-1ß and TNF-a, chondrocytes are provoked to synthesize matrix metalloproteinases - specifically collagenases such as MMP-1, MMP-3, and MMP-13 - along with aggrecanases like ADAMTS5. These enzymes function like enzymatic shears, systematically slicing through structural Type II collagen strands and degrading aggrecan cores. Curcumin suppresses the transcription and secretion of MMP-1, MMP-3, MMP-13, and ADAMTS5 by neutralizing NF-kB and AP-1 activation. Concurrently, it upregulates Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2), an essential transcriptional regulator that represses matrix metalloproteinases at the genomic level. In addition to halting extracellular degradation, curcumin protects chondrocytes from inflammatory apoptosis. Exposure to oxidative stress and inflammatory cytokines typically triggers programmed cell death by activating the intrinsic caspase cascade. Curcumin suppresses this apoptotic pathway by reducing the cleavage of executioner caspase-3, downregulating the pro-apoptotic factor Bax, and elevating anti-apoptotic Bcl-2 expression. Microscopic and histological analyses of osteoarthritic cartilage treated with curcumin consistently show robust Safranin O staining, intact surface regularity, preserved chondrocyte density, and significantly reduced Osteoarthritis Research Society International (OARSI) degradation scores. Within tendon biology, curcumin promotes active tissue regeneration (tenogenesis) rather than inert scar formation. In animal models of tendon rupture and surgical repair, curcumin guides tendon-derived stem and progenitor cells (TSPCs) toward mature tenocyte differentiation. This lineage-specific differentiation is orchestrated primarily through activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and Wnt/ß-catenin signaling cascades. As stem cells commit to the tenogenic pathway, they significantly upregulate crucial structural and phenotypic markers, including epithelial cell adhesion molecule (EpCAM), tenomodulin, and the master tendon transcription factor Scleraxis. Through this guided differentiation, curcumin supports the preferential synthesis and organized deposition of high-tensile Type I collagen fibers, the primary architectural building blocks of healthy tendons. Injured tendons typically fill with disorganized, loose Type III collagen, which forms a structurally inferior, compliant scar. Curcumin supplementation promotes the progressive maturation from primitive Type III collagen to densely packed, parallel Type I collagen fibrils, restoring native tensile strength and mechanical breaking force. A major clinical challenge following tendon surgery is the development of peritendinous adhesions, in which excessive fibrotic scar tissue binds the healing tendon to its synovial sheath, restricting range of motion and joint gliding. Postoperative tendon repair involves a balance between extrinsic healing (in which exterior fibroblasts infiltrate the defect and deposit messy scar tissue) and intrinsic healing (in which tenocytes within the tendon substance reconstruct the matrix). Curcumin suppresses excessive peritendinous inflammation and extrinsic fibrosis while accelerating intrinsic tenocyte repair. Biomechanical testing confirms that local or systemic curcumin administration yields lower adhesion scores, increased gliding distances, and superior functional mobility without sacrificing structural load-bearing capacity. Comparative Clinical Efficacy and Systemic Safety ProfilesTranslating cellular findings into clinical practice requires weighing therapeutic outcomes against systemic safety profiles. While synthetic NSAIDs deliver potent, rapid analgesia during acute musculoskeletal pain events, their chronic administration is constrained by systemic toxicities across multiple organ systems.In randomized, active-controlled clinical trials of knee osteoarthritis, optimized curcumin preparations have demonstrated clinical pain reduction and functional recovery comparable to standard therapeutic doses of NSAIDs. In a randomized, open-label parallel-arm study evaluating 139 patients with symptomatic knee osteoarthritis, subjects received either 500 mg of a bio-enhanced curcumin extract three times daily or 50 mg of diclofenac sodium twice daily for 28 consecutive days. Patients treated with curcumin demonstrated comparable improvements in pain intensity on the Visual Analogue Scale (VAS) and functional scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) at days 14 and 28, showing no statistically significant difference in therapeutic efficacy compared to diclofenac. However, the systemic tolerability profiles between the treatments diverged markedly. Overall adverse events occurred in only 13% of the curcumin group compared to 38% of the diclofenac cohort. In the diclofenac arm, 28% of patients developed dyspeptic symptoms severe enough to require concurrent treatment with H2-receptor antagonists or proton pump inhibitors to prevent mucosal ulceration, whereas no patients in the curcumin cohort required gastroprotective intervention. Furthermore, the curcumin cohort experienced a significant reduction in flatulence and digestive discomfort, demonstrating beneficial gastric and intestinal cytoprotective effects. These safety observations are consistent across broader systematic reviews and meta-analyses. Nonsteroidal anti-inflammatory agents inherently compromise gastrointestinal integrity by systematically depleting cytoprotective prostaglandins, leaving the gastric epithelium vulnerable to acid erosion and hemorrhage. In addition, systemic inhibition of renal and vascular COX enzymes by NSAIDs reduces renal perfusion and disrupts the balance between prostacyclin and thromboxane, elevating the risk of fluid retention, hypertension, and adverse cardiovascular thrombotic events. Curcumin does not suppress these physiological prostanoid pathways, making it free from ulcerogenic, nephrotoxic, and cardiotoxic properties at therapeutic dosages.
A longstanding limitation of standard curcumin supplementation in clinical settings has been its low oral bioavailability. Native curcuminoids are highly lipophilic, poorly soluble in aqueous gastric fluids, and subject to rapid hepatic and intestinal phase II metabolism into inactive glucuronides and sulfates, leading to swift biliary and fecal excretion. Consequently, raw culinary turmeric powders struggle to achieve the therapeutic systemic circulating concentrations required to reach poorly vascularized joint and tendon compartments. Modern pharmacognosy has addressed this pharmacodynamic hurdle through advanced delivery formulations. Modern strategies - such as co-administration with the natural alkaloid piperine (which inhibits hepatic glucuronidation), micellar dispersions, phytosomal phospholipid complexes, and bio-enhanced submicron dispersions - elevate systemic blood bioavailability by ten- to thirty-fold compared to unformulated extracts. These modern delivery platforms ensure that therapeutic concentrations reach synovial fluid, subchondral bone, and fibrous tendon sheaths without requiring excessive oral dosing. Conclusions and Translational Clinical ImplicationsThe biological and clinical evidence reveals distinct physiological paths for NSAIDs and curcumin in orthopedic recovery. While NSAIDs remain powerful tools for the brief alleviation of acute, unmanageable pain, their ongoing administration during active tissue healing presents substantial biological compromises. Tendons and cartilage require a controlled, transient inflammatory cascade to signal cell recruitment, stimulate stem cell differentiation, and direct extracellular matrix synthesis. By completely shutting down cyclooxygenase enzymes and depleting local prostaglandins, NSAIDs disrupt this regenerative cascade. The resulting cellular consequences - including chondrocyte cell cycle arrest, proteoglycan loss, suppression of tenocyte migration, and weakened collagen tensile strength at the tendon-to-bone interface - demonstrate that pain relief from NSAIDs frequently comes at the cost of the structural integrity of healing connective tissues.In contrast, curcumin provides a tissue-preserving alternative that decouples pain and inflammation control from cellular suppression. Operating upstream at the level of NF-kB and AP-1 transcriptional activation, curcumin attenuates the expression of pro-inflammatory cytokines while leaving the physiological baseline of cellular metabolism intact. In cartilage, it actively represses the matrix-degrading enzymes MMP-1, MMP-3, MMP-13, and ADAMTS5, maintains water-binding proteoglycan content, and protects chondrocytes from inflammatory apoptosis. In damaged tendons, curcumin stimulates tenogenic differentiation of local stem cells via PI3K/Akt signaling, supports the proper maturation of dense Type I collagen fibers, and prevents restrictive peritendinous scar adhesions, preserving both joint mobility and mechanical breaking strength. From a translational perspective, these findings indicate that clinical protocols should reconsider relying on continuous NSAIDs as the default intervention for connective tissue injuries, post-surgical recovery, and chronic degenerative conditions. Where synthetic NSAIDs are deemed necessary, their use should be confined to short-term acute flare-ups to avoid interrupting early tissue remodeling. For long-term joint preservation, ongoing tendinopathy rehabilitation, and chronic osteoarthritis management, optimized bio-enhanced curcumin formulations deliver pain relief and functional restoration comparable to conventional pharmaceuticals, all while preserving the biological processes required for lasting musculoskeletal repair. References: NSAID therapy effects on healing of bone, tendon, and the enthesis The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Conservative management of symptomatic knee osteoarthritis - PMC Positives and negatives of nonsteroidal anti-inflammatory drugs in (PDF) Conservative management of symptomatic knee osteoarthritis Non-steroidal anti-inflammatory drugs influence cartilage healing Is Curcumine Useful in the Treatment and Prevention of ... - PMC - NIH Efficacy and mechanisms of curcumin in the treatment of osteoarthritis Biological actions of curcumin on articular chondrocytes - PubMed Curcumin slows osteoarthritis progression and relieves ... - PMC - NIH Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Anti-inflammatory management for tendon injuries - friends or foes? The mechanistic role of curcumin on matrix metalloproteinases in Therapeutic effects of turmeric or curcumin extract on pain and Curcumin inhibits chondrocyte apoptosis and inflammation in ... - PMC Analysis of the mechanism of curcumin against osteoarthritis using Synergistic enhancement of tendon-to-bone healing via anti ... - PMC A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis A randomized, pilot study to assess the efficacy and safety ... - PubMed Effectiveness of curcuminoids in the treatment of knee osteoarthritis THE EFFECTS OF TRADITIONAL STRENGTHENING EXERCISES Putting Some Muscle into Osteoarthritis | Annals of Internal Medicine Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Calebin A, a Compound of Turmeric, Down-Regulates Inflammation The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to Chiropractor in Toronto, ON, Canada :: Head and Neck Pain Investigation of the association of long-term NSAID use with ... - PMC Curcumin Improves Functional Recovery of Ruptured Tendon by Chemically modified curcumin (CMC2.24) alleviates osteoarthritis Curcumin improves age-related and surgically induced osteoarthritis (PDF) Curcumin Improves Functional Recovery of Ruptured Tendon Investigation of the effects of umbilical cord-derived mesenchymal Effect of curcumin-loaded polycaprolactone scaffold on Achilles Controlled release of curcumin from curcumin-loaded nanomicelles Efficacy and safety of combination of curcuminoid complex ... - PMC The efficacy of Curcuma Longa L. extract as an adjuvant therapy in
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6653) The Ultimate Guide to Cellular Longevity: NAD+, Methylation, and Senolytics 
Date:
September 10, 2026 10:57 AM
Introduction: Understanding Cellular Aging and Energy DeclineBiological aging represents a progressive decline in cellular maintenance, structural repair, and energy generation. Over decades, tissues experience an attrition of functional reserves, compromised stress resilience, and persistent low-grade systemic inflammation. At the cellular scale, biological degeneration is driven by a failure to generate bioenergetic fuel, repair genetic code, and clear metabolic waste.Cellular aging is characterized by interconnected biological disruptions known as the hallmarks of aging. These encompass genomic instability, epigenetic alterations, mitochondrial decay, loss of proteostasis, and cellular senescence. Rather than operating as isolated occurrences, these phenomena establish a self-reinforcing degenerative cycle: declining cellular power generation impairs enzymatic genetic repair, promoting the accumulation of damaged cells that enter irreversible growth arrest and poison surrounding healthy tissues. Mitigating cellular aging requires examining how microscopic bioenergetic pathways deteriorate and evaluating how targeted nutritional and biochemical interventions can restore cellular homeostasis. The Role of Mitochondria and ATP ProductionEvery biological function - from muscular contraction to continuous DNA replication - depends on adenosine triphosphate (ATP), the primary biochemical energy currency of living systems. Cells produce the vast majority of this energy within mitochondria through oxidative phosphorylation. Within these specialized organelles, metabolic intermediates derived from dietary carbohydrates and lipids donate high-energy electrons to the electron transport chain. The flow of these electrons across protein complexes establishes an electrochemical proton gradient across the inner mitochondrial membrane, driving ATP synthase to manufacture ATP.A youthful cell functions like an efficient municipal power grid, dynamically matching energetic demands with immediate ATP output. However, as biological aging progresses, mitochondrial efficiency declines. The electron transport chain becomes structurally leaky, inadvertently shedding electrons that react with ambient molecular oxygen to produce reactive oxygen species (ROS). While regulated levels of ROS participate in vital intracellular signaling, chronic excess induces widespread oxidative stress. Mitochondria are exceptionally vulnerable to this oxidative burden because they carry their own circular genetic material, known as mitochondrial DNA (mtDNA). Unlike nuclear DNA, mtDNA lacks the protective shielding of histone proteins and possesses rudimentary repair systems. As a result, mtDNA sustains cumulative oxidative damage, encoding increasingly defective electron transport chain proteins. This dynamic generates a bioenergetic deficit: degraded mitochondria synthesize progressively less ATP while emitting greater volumes of damaging free radicals. Deprived of optimal ATP reserves, cells lack the energy necessary to drive vital enzymatic repair cascades, accelerating structural degeneration and functional exhaustion. How Cellular Senescence Accelerates the Aging ProcessWhen healthy cells confront critical physiological damage - such as severe telomere attrition, persistent DNA double-strand breaks, or oxidative stress - they activate protective cell cycle arrest pathways governed primarily by the p53/p21^CIP1 and p16^INK4a/Rb molecular checkpoints. This defensive shutdown, termed cellular senescence, permanently prevents the replication of potentially premalignant or mutated cells.Senescent cells, colloquially known as "zombie cells," enter a state of permanent growth arrest while actively resisting programmed cell death (apoptosis). Over time, these cells accumulate within adipose depots, skeletal muscle, the vascular endothelium, and major organs, largely because immune surveillance and clearance pathways simultaneously lose functional efficiency. The systemic danger of senescent cells stems from their secretome. Rather than remaining biologically inert, senescent cells develop a hyperactive secretory state termed the Senescence-Associated Secretory Phenotype (SASP). The SASP is a destructive mixture of pro-inflammatory cytokines, chemokines, extracellular matrix-degrading matrix metalloproteinases (MMPs), and reactive oxygen species. Through this toxic secretome, even a small burden of senescent cells can impair whole-tissue architecture. SASP factors degrade surrounding structural proteins, induce insulin resistance in neighboring metabolic cells, and biochemically force adjacent healthy cells into secondary senescence. This persistent paracrine signaling fuels chronic, sterile, low-grade systemic inflammation, termed "inflammaging," which accelerates systemic tissue degeneration and elevates susceptibility to degenerative age-related pathologies. Nicotinamide Riboside (NR) and the NAD+ Salvage PathwayThe Biochemistry of NAD+ Depletion Over TimeNicotinamide adenine dinucleotide (NAD+) is an indispensable coenzyme present in every living cell. NAD+ fulfills a dual biological mandate: it serves as a central redox cofactor that shuttles electrons between cellular metabolic reactions, and it functions as an obligatory consumable substrate for regulatory enzymes that preserve cellular viability. In its redox capacity, NAD+ accepts electrons to form NADH during glycolysis, the tricarboxylic acid (TCA) cycle, and fatty acid beta-oxidation, subsequently donating those electrons to Complex I of the respiratory chain to power ATP synthesis.
The primary enzymatic driver of age-related NAD+ destruction is CD38, a membrane-bound glycohydrolase expressed on immune cells that is upregulated in response to chronic SASP exposure. Concurrently, lifelong genotoxic damage causes persistent activation of Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that cleaves the glycosidic bonds of NAD+ to assemble branched poly(ADP-ribose) chains at DNA lesion sites. Because PARP-1 consumes NAD+ without directly recycling the molecule, chronic DNA damage depletes intracellular NAD+ pools, impairing bioenergetics and limiting sirtuin activity. How NR Efficiently Boosts Cellular NAD+ LevelsThe mammalian body maintains its NAD+ supply through three distinct biosynthetic routes: the de novo pathway from dietary L-tryptophan, the Preiss-Handler pathway from nicotinic acid (niacin), and the NAD+ Salvage Pathway. The de novo pathway requires substantial energy expenditure, consuming roughly sixty milligrams of dietary tryptophan to yield a single milligram of NAD+. The Preiss-Handler pathway, while effective, can induce cutaneous prostaglandin-mediated flushing at therapeutic intakes. Consequently, the salvage pathway serves as the primary mechanism for maintaining intracellular NAD+ pools.The salvage pathway recycles the breakdown product nicotinamide (NAM), which is released whenever NAD+-consuming enzymes execute their functions. Under normal conditions, cells convert free nicotinamide into nicotinamide mononucleotide (NMN) via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), after which NMN adenylyltransferases (NMNAT1–3) complete the conversion into NAD+. However, NAMPT expression declines with advancing age, chronic inflammation, and metabolic stress, limiting the recycling capacity of the cell. Nicotinamide Riboside (NR) is a naturally occurring pyridine nucleoside that bypasses this enzymatic bottleneck. Upon cellular entry via equilibrative nucleoside transporters, NR is directly phosphorylated into NMN by nicotinamide riboside kinases (NRK1 and NRK2) using a single molecule of ATP. Because the NRK pathway remains intact and robust across the lifespan, NR provides an efficient alternative entry point into the NAD+ salvage cascade. Clinical evaluations in humans confirm the safety, bioavailability, and pharmacokinetics of oral NR supplementation. Randomized, double-blind, placebo-controlled trials reveal that oral NR chloride produces dose-dependent increases in steady-state whole blood NAD+ concentrations. Dosing regimens of 100 mg, 300 mg, and 1,000 mg daily elevate blood NAD+ levels by approximately 22%, 51%, and up to 142%, respectively, within two weeks of administration, maintaining these elevations throughout continuous use. High-resolution metabolomic analyses also demonstrate parallel elevations in nicotinic acid adenine dinucleotide (NAAD), establishing it as a reliable biomarker of active intracellular NAD+ synthesis without hepatic or systemic toxicity. Sirtuin Activation and DNA Repair MechanismsReplenishing intracellular NAD+ supports functions beyond mitochondrial ATP generation. NAD+ functions as an obligatory cofactor for sirtuins (SIRT1 through SIRT7), a family of class III histone and non-histone protein deacetylases that regulate stress resilience, metabolic homeostasis, and cell survival. Sirtuins couple the removal of acetyl groups from target lysine residues to the stoichiometric cleavage of NAD+, producing nicotinamide and O-acetyl-ADP-ribose. In states of NAD+ deficiency, sirtuin enzymes remain inactive regardless of cellular demand.In the nucleus, SIRT1 coordinates defense against cellular decline. When activated by restored NAD+ levels, SIRT1 deacetylates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a), the master transcriptional coactivator of mitochondrial biogenesis. This deacetylation stimulates mitochondrial replication and assembly, expanding functional respiratory capacity. Concurrently, SIRT1 deacetylates the p65 subunit of nuclear factor-kappa B (NF-kB), suppressing the transcription of pro-inflammatory cytokines. In the mitochondria, SIRT3 utilizes NAD+ to deacetylate metabolic enzymes and superoxide dismutase 2 (SOD2), enhancing the organelle's capacity to neutralize reactive oxygen species. At the same time, cellular NAD+ levels directly regulate genomic integrity through PARP-1. When genotoxic stress or oxidative damage induces single- or double-strand DNA breaks, PARP-1 binds to the damaged termini using its zinc-finger domains. Bound PARP-1 hydrolyzes NAD+ to synthesize extensive, negatively charged poly(ADP-ribose) polymers on itself and adjacent histones. This modification relaxes chromatin architecture and establishes an electrostatic scaffold that recruits base excision repair and homologous recombination complexes. Recent discoveries demonstrate close crosstalk between sirtuins and PARP-1 during DNA repair. PARP-1 recruits SIRT1 to double-strand breaks, where SIRT1 deacetylates the chromatin-remodeling ATPase BRG1 to displace nucleosomes and facilitate homologous recombination. However, because PARP-1 and SIRT1 draw from the same intracellular NAD+ pool, severe NAD+ depletion forces a biological compromise: PARP-1 consumes the scarce remaining cofactor to address DNA damage, leaving sirtuins deactivated. Restoring NAD+ via NR prevents this deficit, enabling concurrent genomic repair and sirtuin-mediated metabolic defense. Quercetin: A Powerful Senolytic and mTOR RegulatorClearing Senescent "Zombie" Cells from TissuesThe accumulation of senescent cells has driven interest in senolytics: molecules that selectively eliminate senescent cells while sparing healthy, non-senescent populations. Senolytic agents exploit a specific vulnerability in senescent cells. Because senescent cells produce cytotoxic, pro-inflammatory SASP factors that would normally induce their own death, they become dependent on upregulated Senescent Cell Anti-Apoptotic Pathways (SCAPs) to survive. The SCAP network involves anti-apoptotic proteins (such as BCL-2 and BCL-xL), the PI3K/Akt kinase cascade, and cyclin-dependent kinase inhibitors.Quercetin is a polyphenolic flavonoid found in capers, red onions, apples, and the flower buds of Sophora japonica. Beyond its classical antioxidant properties, quercetin functions as a senolytic compound that exerts multi-target inhibitory effects across the SCAP network. By inhibiting the upstream PI3K/Akt survival axis and downregulating anti-apoptotic defenses, quercetin disrupts the signaling that protects senescent cells from intrinsic apoptosis. Deprived of these survival signals, senescent cells undergo programmed cell death. Preclinical studies demonstrate that senolytic protocols utilizing quercetin - often combined with the tyrosine kinase inhibitor dasatinib - reduce senescent cell burden across multiple tissues. This targeted clearance lowers circulating SASP factors, attenuates tissue fibrosis, restores endothelial reactivity, and improves functional health span. By removing senescent cells, quercetin mitigates the primary driver of chronic, low-grade inflammaging. Modulating the mTOR Pathway for Optimal AutophagyThe mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that coordinates cellular metabolism by balancing anabolic growth with catabolic recycling. Operating within two multiprotein complexes - mTORC1 and mTORC2 - the mTOR pathway integrates signals from amino acids, growth factors, and intracellular energy levels. In nutrient-rich environments, mTORC1 promotes protein synthesis, lipogenesis, and cellular growth, while suppressing catabolic breakdown. Conversely, nutrient scarcity downregulates mTORC1, activating autophagy.Autophagy is an intracellular degradation system that packages damaged organelles, misfolded protein aggregates, and biological debris into double-membraned autophagosomes for lysosomal degradation and recycling. A specialized branch of this pathway, mitophagy, selectively targets and clears damaged mitochondria. In modern metabolic conditions characterized by continuous caloric intake, mTORC1 can remain persistently active. This persistent signaling suppresses autophagy, causing damaged organelles and toxic aggregates to accumulate within tissues. Quercetin functions as a natural modulator of mTOR signaling. By inhibiting upstream PI3K/Akt signaling and activating intracellular energy sensors, quercetin attenuates overactive mTORC1, mimicking the metabolic effects of caloric restriction. This down-regulation relieves inhibition on the ULK1 autophagy initiation complex, stimulating both general autophagy and mitophagy. As autophagy proceeds, cells clear protein aggregates and eliminate damaged mitochondria, supporting cellular longevity and proteostasis. Enhancing Absorption: Phytosomes and Dietary FatsDespite the biological activities of quercetin identified in experimental models, its clinical translation has historically been limited by poor oral bioavailability. Raw quercetin aglycone is a crystalline, hydrophobic polyphenol with poor solubility in water and gastrointestinal fluids. When ingested in unformulated powder forms, quercetin molecules aggregate in the gut lumen, resisting dissolution and passive absorption. Consequently, the vast majority of an unformulated dose passes into the colon unabsorbed, where it undergoes microbial degradation without reaching meaningful systemic concentrations.To address these pharmacokinetic limitations, advanced delivery systems such as phytosomes were engineered. A phytosome is a 100% food-grade molecular complex where individual polyphenolic molecules are bound to dietary phospholipids, typically sunflower-derived phosphatidylcholine. Unlike a classical liposome - which encapsulates water-soluble compounds inside an aqueous core enclosed by a lipid bilayer - a phytosome forms an amphiphilic complex at the molecular level. The polar head of the phosphatidylcholine molecule forms hydrogen bonds with the hydroxyl groups of the quercetin molecule, while its lipophilic fatty acid tails extend outward. This structural arrangement shields the polar regions of the flavonoid, creating a lipid-compatible complex that integrates smoothly into the intestinal mucosa.
The Importance of Methylation in Healthy AgingVitamin B-Complex and Choline as Essential Methyl DonorsMethylation is an essential biochemical process occurring billions of times each second across all human tissues. It involves the transfer of a single-carbon unit - a methyl group consisting of one carbon atom bound to three hydrogen atoms - (CH3) - from a donor molecule to diverse recipients, including DNA, RNA, structural proteins, neurotransmitters, and membrane phospholipids. This transfer of one-carbon units is coordinated by the methionine-homocysteine cycle, which sustains genetic stability, detoxification pathways, and cellular repair.At the center of this pathway sits S-adenosylmethionine (SAM), the universal methyl donor in human biology. When a methyltransferase enzyme transfers a methyl group from SAM to an acceptor molecule, SAM is converted into S-adenosylhomocysteine (SAH). SAH functions as a potent competitive inhibitor of intracellular methyltransferases. To maintain functional methylation, SAH is rapidly hydrolyzed into homocysteine, a sulfur-containing amino acid that must be remethylated or cleared through transsulfuration. Homocysteine clearance proceeds through two distinct remethylation pathways. The primary route operates across most tissues via the enzyme methionine synthase, which requires vitamin B12 in its active methylcobalamin form. Methionine synthase transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF, the active form of folate) to homocysteine, regenerating methionine. The ongoing production of 5-MTHF depends on the enzyme methylenetetrahydrofolate reductase (MTHFR), which utilizes riboflavin (vitamin B2) as a cofactor. Alternatively, excess homocysteine can be routed into the transsulfuration pathway by vitamin B6 (as pyridoxal-5'-phosphate) to synthesize cystathionine, cysteine, and ultimately the antioxidant glutathione. A secondary remethylation pathway, active predominantly in hepatic and renal tissues, bypasses folate entirely. In this route, dietary choline is oxidized to betaine (trimethylglycine or TMG). The enzyme betaine-homocysteine S-methyltransferase (BHMT) then transfers a methyl group from betaine directly to homocysteine, yielding methionine and dimethylglycine. When dietary intake of active B-vitamins or choline is insufficient, or when genetic variations like MTHFR polymorphisms reduce pathway flux, the methylation cycle slows. Homocysteine accumulates in circulation, promoting vascular and neurological inflammation, while SAM reserves decline, restricting cellular methylation capacity. Understanding DNA Methylation and Epigenetic HealthEvery somatic cell in an organism carries an identical genetic code. Cellular differentiation and tissue-specific functions are governed by the epigenome: a regulatory layer of chemical modifications that dictates gene expression without altering underlying DNA sequences. DNA methylation represents the primary and most stable epigenetic modification. In this process, DNA methyltransferase (DNMT) enzymes utilize methyl groups donated by SAM to add a methyl tag to cytosine bases adjacent to guanine residues, forming 5-methylcytosine within CpG dinucleotide sites.Under physiological conditions, DNA methylation maintains genomic stability and coordinates transcription. Methylation of promoter regions condenses chromatin, repressing transposable elements and silencing genes inappropriate for a given cell type. Conversely, hypomethylated promoters maintain an open chromatin state, allowing transcription factors to bind and initiate gene expression. During biological aging, this epigenetic landscape undergoes progressive dysregulation, a phenomenon termed "epigenetic drift". Aging cells experience global hypomethylation alongside focal hypermethylation of specific gene promoters. Global loss of methyl tags destabilizes the genome, activating retrotransposons and pro-inflammatory pathways. Simultaneously, hypermethylation at targeted promoter sites silences critical tumor suppressor genes and DNA repair complexes. This systematic change in DNA methylation patterns is consistent across populations, allowing researchers to develop molecular "epigenetic clocks". Algorithms such as the Horvath clock, PhenoAge, and GrimAge quantify biological age by profiling the methylation status of specific CpG sites across the genome. These clocks assess whether individuals are aging faster or slower than their chronological years. Ensuring a steady supply of methyl donors and preventing unnecessary SAM depletion supports DNMT activity, maintaining epigenetic patterns and genomic stability. How the Methylation Cycle Impacts Energy and Cognitive FocusBeyond long-term epigenetic regulation, the methylation cycle directly modulates immediate biochemical processes that govern daily energy, neurotransmission, and cognitive focus. Compromised methylation capacity frequently manifests as cognitive slowing, executive fatigue, and reduced physical stamina.A major consumer of methyl reserves is the endogenous synthesis of creatine. Approximately 40% of all SAM-derived methyl groups in the human body are utilized by guanidinoacetate N-methyltransferase (GAMT) in the liver to synthesize creatine. Creatine then translocates to the brain and skeletal muscle, where it is phosphorylated into phosphocreatine. Phosphocreatine functions as a rapid energy buffer, donating a high-energy phosphate group to regenerate ADP into ATP in milliseconds during demanding physical or cognitive tasks. When methyl donor availability falls, endogenous creatine synthesis drops, depleting phosphocreatine reserves and increasing susceptibility to neuromuscular and cognitive fatigue. Methylation is equally central to central nervous system architecture. SAM provides methyl groups to convert phosphatidylethanolamine into phosphatidylcholine, the predominant phospholipid comprising neuronal cell membranes and the myelin sheaths that insulate axons. Intact myelin preserves rapid action potential conduction throughout the nervous system. Furthermore, free choline derived from this pathway is the direct precursor to acetylcholine, the neurotransmitter required for attention, working memory, and learning. The methylation cycle also governs monoamine neurotransmitter metabolism. SAM is required for the synthesis of adrenaline (epinephrine) from noradrenaline, while catechol-O-methyltransferase (COMT) relies on SAM to degrade dopamine and norepinephrine within the prefrontal cortex. Sluggish methylation disrupts this balance, contributing to cognitive fatigue, mood variability, and impaired mental performance. Building a Comprehensive Longevity ProtocolSynergizing NR, Quercetin, and Methylated B-VitaminsLongevity supplementation often falters when single molecules are administered in isolation, ignoring interconnected metabolic pathways. Designing an effective cellular longevity protocol requires combining complementary mechanisms that reinforce one another while preventing secondary metabolic deficits. The combination of Nicotinamide Riboside, Quercetin Phytosome, and Methylated B-Vitamins illustrates this multi-target synergy.This synergy is grounded in the direct biochemical intersection between the NAD+ salvage pathway and the methylation cycle. When high-dose NR is supplemented to boost systemic NAD+, sirtuins and PARP enzymes consume the newly synthesized cofactor, generating substantial quantities of free nicotinamide (NAM). This intracellular nicotinamide faces two primary metabolic fates: it can be recycled back into NAD+ through the NAMPT-dependent salvage loop, or it can be cleared via methylation. When the influx of nicotinamide exceeds salvage recycling capacity, the excess is cleared to avoid feedback inhibition of sirtuin enzymes. To accomplish this, the enzyme nicotinamide N-methyltransferase (NNMT) transfers a methyl group from SAM directly onto nicotinamide, forming 1-methylnicotinamide (1-MNA/MNAM), which is subsequently excreted in urine. Prolonged, high-dose precursor administration without nutritional methyl support can elevate NNMT flux, depleting intracellular SAM reserves. As methyl groups are consumed clearing nicotinamide, the cellular SAM-to-SAH ratio falls, which can elevate circulating homocysteine and reduce methyl availability for DNA methylation and neurotransmitter synthesis. Co-administering a fully methylated B-complex alongside choline or betaine addresses this potential bottleneck. Providing active methyl donors (such as 5-MTHF, methylcobalamin, and betaine) maintains the one-carbon donor pool. Even during increased NNMT activity, SAM pools remain stable, protecting DNA methylation fidelity and maintaining homocysteine within safe parameters. Quercetin reinforces this protocol through complementary mechanisms. By clearing senescent cells and reducing SASP-mediated inflammation, quercetin downregulates CD38, the primary enzyme responsible for age-related NAD+ degradation. Suppressing CD38 prevents unnecessary breakdown of newly synthesized NAD+, enhancing the efficiency of NR supplementation. Furthermore, while NR provides the NAD+ necessary to activate SIRT1-driven mitochondrial biogenesis, quercetin concurrently modulates mTORC1 to stimulate autophagy. This coordinated action ensures that newly generated mitochondria operate in an environment cleared of proteotoxic cellular debris. The Crucial Role of Magnesium Glycinate and Zinc in Cellular FunctionLongevity protocols require essential mineral cofactors to function efficiently. Without adequate divalent minerals acting as enzymatic cofactors and structural stabilizers, metabolic longevity pathways cannot operate at full capacity. Among these, magnesium and zinc are required for cellular repair, genomic stability, and energy production.Magnesium serves as an obligatory cofactor in over 300 enzymatic reactions, primarily through its interaction with ATP. In biological systems, ATP exists predominantly as a chelate with a divalent magnesium ion, forming biologically active Mg2+ -ATP. Every enzymatic reaction that synthesizes, transfers, or consumes cellular energy - including the enzymes of the NAD+ salvage pathway (NRK and NMNAT) and DNA polymerases - strictly requires Mg2+ -ATP as its substrate. Magnesium deficiency impairs these phosphorylation reactions, reducing the cellular utilization of NAD+ precursors. Additionally, magnesium is an essential cofactor for the enzymes that activate dietary B-vitamins into their active forms. Supplying magnesium as magnesium glycinate provides high gastrointestinal bioavailability, minimal laxative effect, and yields glycine to support inhibitory neurotransmission and restful sleep. Zinc serves as a vital structural component for more than 3,000 human transcription factors and enzymatic proteins. Its most prominent structural role in longevity occurs within zinc-finger motifs. These are specialized protein conformations stabilized by a zinc ion coordinated to cysteine and histidine residues. The DNA damage sensor PARP-1 utilizes three zinc-finger domains to identify, track, and physically bind to single- and double-strand DNA breaks. Without adequate intracellular zinc, PARP-1 cannot properly assemble or dock onto damaged chromosomes, impairing DNA repair and increasing genomic instability. Zinc is also an obligatory structural component of copper/zinc superoxide dismutase (Cu/Zn-SOD or SOD1), the primary cytosolic antioxidant enzyme that dismutates superoxide radicals into hydrogen peroxide, protecting mitochondrial membranes and nuclear DNA from premature senescence. Integrating Prebiotics (like Acacia and Inulin) for Gut-Derived Longevity MarkersA comprehensive cellular longevity framework must extend beyond somatic tissues to encompass the gut microbiome. The intestinal microbiome functions as a central regulator of systemic inflammatory tone, immune development, and metabolic signaling. Age-associated dysbiosis - characterized by the loss of beneficial commensals and an overgrowth of pathobionts - frequently leads to breakdown of the intestinal barrier.The gut epithelium consists of a single-cell monolayer sealed by tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and claudins. When this physical barrier is disrupted by poor dietary fiber intake or dysbiosis, gut permeability increases. This allows lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, to enter the portal and systemic circulation. The resulting "metabolic endotoxemia" activates Toll-like receptor 4 (TLR4) on immune cells, inducing NF-kB and systemic pro-inflammatory cytokine production. This persistent gut-derived inflammation exacerbates the SASP, accelerates tissue senescence, upregulates CD38, and drains systemic NAD+ reserves.
These short-chain fatty acids, particularly butyrate, exert direct protective effects on systemic longevity. Butyrate provides the primary metabolic fuel for colonic epithelial cells, supplying more than 70% of their baseline energy needs and supporting mitochondrial function within colonocytes. Furthermore, SCFAs upregulate the expression of epithelial tight junction proteins (ZO-1, occludin, and claudin-1), restoring intestinal barrier integrity and preventing the translocation of inflammatory LPS into systemic circulation. Systemically absorbed butyrate also functions as an endogenous histone deacetylase (HDAC) inhibitor, suppressing pro-inflammatory gene expression and supporting regulatory T cell (T_reg) development. Reducing metabolic endotoxemia dampens systemic inflammation, protecting vascular function and preventing premature NAD+ depletion. Conclusion: The Integrated Cellular Longevity MatrixCellular longevity is achieved not by addressing isolated biomarkers in isolation, but by systematically supporting interconnected biological pathways. As bioenergetic capacity declines, cellular senescence accelerates, epigenetic patterns degrade, and gut barrier integrity weakens. A comprehensive approach addresses these biological vulnerabilities simultaneously.
Quercetin Phytosome clears senescent cells and modulates mTORC1, stimulating autophagy while dampening the inflammatory SASP cascade that accelerates CD38-mediated NAD+ destruction. Methylated B-vitamins, active folate, and choline replenish SAM reserves, balancing the methyl requirements of NNMT-mediated nicotinamide clearance, preserving epigenetic DNA methylation, and maintaining neurotransmitter production. Magnesium glycinate and zinc provide the structural and catalytic foundation required for ATP utilization, B-vitamin activation, and PARP-1 zinc-finger DNA repair docking. Finally, prebiotic fibers generate short-chain fatty acids like butyrate, reinforcing the intestinal barrier and preventing metabolic endotoxemia from fueling systemic inflammation. By coordinating energy replenishment, cellular waste clearance, epigenetic maintenance, and the suppression of systemic inflammation, this unified approach directly addresses the underlying drivers of cellular aging to support long-term physiological vitality.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6650) Is Your Cinnamon Causing Inflammation? The Hidden Risks of a Common Spice
Date:
July 16, 2026 05:28 PM
Cinnamon is widely praised for its ability to improve cellular glucose uptake and support insulin sensitivity, but the direct answer is yes - under specific conditions, consuming cinnamon can cause or trigger inflammation. While cinnamon naturally contains powerful anti-inflammatory polyphenols (like cinnamaldehyde), its potential to drive inflammation boils down to two distinct triggers: the specific variety you ingest, and your individual immune response to its volatile oils. 1. Coumarin-Induced Liver InflammationThe primary metabolic risk stems from Cassia cinnamon, which is the standard, inexpensive variety found on most grocery store spice racks. Cassia contains significant concentrations of a naturally occurring compound called coumarin.
2. Contact Hypersensitivity (Cinnamon Stomatitis)Cinnamaldehyde gives cinnamon its signature warmth and flavor, but it is also a documented contact allergen.
3. Gastrointestinal Mucosal IrritationBecause concentrated spice powders contain highly concentrated volatile oils, taking large doses on an empty stomach can physically irritate the delicate mucous lining of the upper gastrointestinal tract. This localized chemical irritation can mimic or exacerbate inflammatory discomfort in the stomach wall, resulting in heartburn, acid reflux, or cramping.Mitigating the Risk: Ceylon vs. CassiaIf you are leveraging cinnamon as a daily tool for metabolic health and blood sugar management, switching to Ceylon cinnamon (often labeled as "True Cinnamon") fundamentally changes its biochemical impact.
While cinnamon is highly regarded for improving insulin sensitivity and managing blood sugar, it can paradoxically trigger inflammation under specific conditions. The primary systemic risk stems from Cassia cinnamon, the common grocery store variety, which contains high concentrations of a compound called coumarin. When consumed regularly or in large therapeutic doses, coumarin can overwhelm the liver's metabolic pathways, leading to elevated liver enzymes and acute hepatic inflammation. Beyond liver toxicity, cinnamon can also incite localized inflammation; its volatile oil, cinnamaldehyde, can induce a Type IV delayed hypersensitivity reaction known as contact stomatitis - causing painful burning and swelling in the mouth - while concentrated doses can physically irritate the gastrointestinal lining. To safely harness the metabolic benefits of the spice without triggering these inflammatory responses, switching to Ceylon cinnamon ("true cinnamon") is the most effective strategy. Systemically, Ceylon contains only trace, negligible levels of coumarin (0.004% to 0.007%), making it safe for daily medicinal dosing, whereas Cassia contains significant levels (up to 1.0%) that require strict consumption limits to avoid toxicity. Visually and structurally, the two varieties are distinctly different: Ceylon features a light tan color with multiple thin, fragile, and tightly rolled layers, while Cassia is characterized by a dark reddish-brown hue and a single, thick, hard quill that is difficult to break.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6645) Choline: The Liver’s Fat-Export Engine
Date:
June 24, 2026 11:48 AM
Without sufficient choline, the liver's ability to process and export fats grinds to a halt. The Liver’s Fat-Export MechanismThe primary reason the liver requires choline comes down to a specific molecule: phosphatidylcholine (PC).When you eat fats or liberate stored fatty acids, your liver processes them into triglycerides. To move these triglycerides out of the liver and deliver them to muscle or adipose (fat) tissue for energy or storage, the liver has to package them into transport vehicles called VLDL (Very Low-Density Lipoproteins). Phosphatidylcholine forms the essential outer shell of these VLDL transport "boats." If you don't have enough choline, your liver cannot manufacture this outer shell, meaning the boats cannot be built, and fat cannot leave the liver. What Happens When Choline is Deficient?When dietary choline drops below critical levels, a highly predictable cascade of liver dysfunction occurs:
Dietary Benchmarks & SourcesTo prevent fat accumulation and support proper VLDL export, the Food and Nutrition Board establishes specific Adequate Intake (AI) targets, though optimal metabolic and athletic performance may require a more robust baseline.
Summary: Choline acts as a critical logistics coordinator for liver health, serving as a non-negotiable raw material for exporting fat out of the organ. Specifically, the liver relies on choline to produce phosphatidylcholine, a molecule that forms the essential outer shell of Very Low-Density Lipoproteins (VLDL). Think of VLDLs as transport boats designed to safely carry triglycerides out of the liver and deliver them to the rest of the body for energy or storage. Without an adequate dietary supply of choline, the liver simply cannot build these outer shells, causing the entire transport system to grind to a halt and leaving processed fats stranded inside liver cells. When this export mechanism stalls, the stranded fat quickly triggers a highly predictable cascade of liver dysfunction. This buildup leads directly to fat accumulation - historically known as fatty liver disease and now classified as MASLD - which quickly overwhelms the cellular mitochondria. The resulting oxidative stress and cellular injury spark chronic inflammation (MASH), causing liver cells to die and potentially leading to permanent scarring or fibrosis over time. Furthermore, a severe shortage of dietary choline starves the body's methylation cycle, forcing it to deplete vital SAMe pools in a desperate, structurally taxing attempt to manufacture its own phosphatidylcholine.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6643) Can DMAE Help With Cellular Cleanup?
Date:
May 28, 2026 01:38 PM
Yes, DMAE - and specifically its highly bioavailable pharmaceutical ester counterpart, centrophenoxine (meclofenoxate) - hits cellular cleanup mechanisms. However, the way it interacts with a stalled system in Parkinson's Disease (PD) is fundamentally different from standard macroautophagy upregulators like fasting or mTOR inhibitors. Instead of just forcing the cell to create more cleanup vesicles, DMAE addresses the structural and mechanical "traffic jams" that cause the system to stall in the first place. The Parkinson's Stagnation: An Autophagic Traffic JamIn Parkinson’s pathology, the primary breakdown in cellular quality control occurs within the autophagic-lysosomal pathway. The accumulation of misfolded a-synuclein proteins builds up into toxic aggregates (Lewy bodies). This doesn't just form static waste; it actively paralyzes the cell's transport machinery, halting macroautophagy, chaperone-mediated autophagy (CMA), and mitophagy (the clearing of damaged, radical-producing mitochondria).Here is how a healthy version of this pathway is structured: As shown above, a healthy cell relies on seamless transport where an autophagosome encapsulates debris and fuses with an acidic lysosome to form an autolysosome for enzymatic destruction. In a stalled Parkinson's state, this crucial fusion and trafficking step is paralyzed. How DMAE Alters Cleanup DynamicsDMAE approaches this bottleneck through two precise biochemical mechanisms:1. Re-greasing Vesicle Trafficking TracksTo build an autophagosome and move it to a lysosome, a neuron requires highly fluid lipid membranes.
2. Direct a-Synuclein DisruptionClassically, DMAE is famous in longevity research for dissolving lipofuscin - the cross-linked "wear-and-tear" pigment aggregate that accumulates in aging cells. While lipofuscin is structurally distinct from the amyloid-like sheets of a-synuclein, modern molecular profiling has revealed that DMAE derivatives possess a powerful cross-over effect:
Mechanics of Clearance: DMAE vs. Traditional Autophagy Inducers
Summary: In Parkinson’s disease, cellular cleanup stalls because toxic accumulations of misfolded alpha-synuclein proteins physically paralyze the autophagic-lysosomal pathway, creating a mechanical traffic jam that prevents waste-carrying autophagosomes from fusing with digestive lysosomes. Rather than simply triggering the creation of more cleanup vesicles like standard autophagy inducers do, DMAE and its highly bioavailable derivative, centrophenoxine, address this bottleneck structurally. It serves as a direct biochemical precursor to vital membrane phospholipids like phosphatidylcholine, restoring lipid bilayer fluidity and essentially "re-greasing the tracks" so stalled cellular transport machinery can resume normal trafficking and waste elimination. Beyond restoring membrane dynamics, DMAE compounds actively disrupt protein aggregation by changing the conformation of alpha-synuclein, which prevents individual monomers from stacking into the toxic, insoluble sheets that choke the cell's internal quality control. This action mirrors its well-documented ability to dissolve lipofuscin, the cross-linked "wear-and-tear" aging pigment that accumulates in aging cells. While free-base DMAE struggles to penetrate the central nervous system effectively due to competition with choline transporters, the lipophilic ester centrophenoxine easily crosses the blood-brain barrier, making it the superior vehicle for restoring neural membrane fluidity and clearing out stalled neurodegenerative debris.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6641) Is there anything else DLPA can do be sides Pain management and Mood?
Date:
May 22, 2026 04:29 PM
Here is what else DLPA can do:
When diving deeper into the physiological applications of DLPA, there are several advanced, highly specific mechanisms that make it particularly interesting, especially regarding athletic performance, metabolic pathways, and cellular recovery.
Here are a few of the more complex, nuanced roles of DLPA in the body:
By supplementing with L-phenylalanine, the brain has a steady supply of precursor material to maintain dopamine synthesis. This helps delay the onset of CNS fatigue, allowing for sustained mental drive, higher intensity, and better neurological output throughout a grueling session.
Because the D-phenylalanine in DLPA does not interfere with inflammation or COX enzymes—working entirely by shielding circulating endorphins—it provides musculoskeletal comfort without compromising the cellular signaling required for muscle repair and growth. It allows the body's natural inflammatory repair mechanisms to run their course uninterrupted.
The enzyme responsible for this final step (PNMT) relies entirely on S-adenosylmethionine (SAMe) to donate a methyl group. If the methylation cycle is sluggish or deficient in necessary cofactors (like methylated B-vitamins), the catecholamine cascade bottlenecks at norepinephrine. Therefore, DLPA's ability to fully support the adrenal axis is directly dependent on the efficiency of the body's methylation pathways.
Would you like to explore how to position this mTOR-safe, CNS-supporting angle into a specific educational breakdown for a retail or blog audience?
Summary:
Beyond its foundational role in chronic pain relief, DLPA serves as a versatile precursor that supports several advanced metabolic, cognitive, and physical functions. Because the L-phenylalanine half converts into tyrosine, it provides the essential raw materials required for thyroid hormone synthesis (T3 and T4), melanin skin pigmentation production, and the release of cholecystokinin (CCK), a gut peptide that signals satiety and regulates appetite. Furthermore, by elevating dopamine and norepinephrine, DLPA enhances executive function, working memory, and focus, making it a valuable asset in nootropic protocols and a supportive tool for rebuilding depleted neurotransmitter stores during substance recovery.
In the context of high-intensity athletic performance, DLPA offers unique physiological advantages for training and recovery. It directly combats central nervous system (CNS) fatigue by replenishing the dopamine depleted during heavy resistance training, thereby maintaining neural drive without interrupting muscle protein synthesis. Unlike traditional NSAIDs, which blunt the acute inflammatory response and stall the mTOR pathway, DLPA provides musculoskeletal comfort solely by shielding endogenous opioids (endorphins and enkephalins) from enzymatic breakdown. This allows the natural muscle-repair mechanisms to run their course uninterrupted while simultaneously prolonging the post-exercise "lifter's high." However, its full efficacy remains dependent on a healthy methylation cycle, as the final conversion of norepinephrine to adrenaline requires adequate methyl donors like SAMe.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6640)
Date:
May 22, 2026 12:27 PM
To understand how it works, it helps to break down the molecule. DLPA is a 50/50 mixture of two stereoisomers (mirror-image structures) of the essential amino acid phenylalanine:
Chronic pain rarely exists in a vacuum—it is deeply linked to systemic fatigue, mood degradation, and depression. Because chronic pain is neurologically exhausting, it frequently depletes the brain's stimulating neurotransmitters.
The L-phenylalanine half of DLPA acts as the raw precursor material for the catecholamine pathway. Your body converts it into tyrosine, which is then synthesized into dopamine, norepinephrine, and epinephrine (adrenaline). By combining both forms, DLPA provides a dual-action effect: the D-form raises the pain threshold, while the L-form combats the mental fatigue and mood dips that inevitably accompany long-term discomfort.
Key insight: Because DLPA relies on shifting enzyme levels and allowing endorphins to accumulate, it is primarily effective for chronic pain (like osteoarthritis or lingering injuries) rather than acute, immediate pain. It often requires several days to weeks of consistent use to reach its full therapeutic effect.
Summary:
DLPA (DL-phenylalanine) is a nutritional supplement combining two mirror-image forms of an essential amino acid to provide a unique approach to chronic pain management. Unlike standard pain relievers that suppress inflammation, the "D" form of the molecule acts as a biochemical shield for the body's built-in painkilling system. It functions as an enkephalinase inhibitor, meaning it blocks the specific enzymes responsible for destroying circulating endorphins and enkephalins. By protecting these natural opioids from premature breakdown, DLPA allows them to accumulate and remain active longer, effectively raising the body's natural pain threshold.
Because chronic pain is neurologically exhausting and frequently leads to fatigue or lowered mood, the "L" half of the supplement provides critical mental support. L-phenylalanine serves as a raw precursor for synthesizing stimulating neurotransmitters, including dopamine, norepinephrine, and epinephrine (adrenaline). Together, this dual-action mechanism addresses both the physical sensation of lingering discomfort and the mental fatigue that accompanies it, making DLPA uniquely suited for sustained, long-term pain conditions rather than immediate, acute injuries.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6639)
Date:
December 05, 2025 04:06 PM
Since mitochondria produce about 90% of the energy (ATP) your body uses, improving their function is like upgrading the engine in a car: you get more power, better fuel efficiency, and a smoother ride.
Here is the breakdown of how boosting mitochondria translates to "feeling better" physically and mentally.
Here are the top supplements with the strongest evidence for mitochondrial health, categorized by how they work.
Optimizing mitochondrial health is a systemic strategy that links gut health to overall vitality, largely driven by Short-Chain Fatty Acids (SCFAs) like butyrate, which act as both fuel and signaling agents to enhance energy production in the brain, muscles, and liver. By stimulating mitochondrial biogenesis (the creation of new energy factories via the PGC-1a gene) and fueling the Electron Transport Chain, SCFAs - along with targeted supplements like PQQ, CoQ10, and Urolithin A - directly increase ATP output while simultaneously clearing out damaged cells through mitophagy. This biological upgrade results in tangible benefits, including sustained physical endurance, sharper cognitive focus, and stabilized mood, effectively turning the body’s cells into more efficient engines that produce more power with less oxidative "exhaust."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6630)
Date:
May 30, 2024 12:46 PM
Stevia has garnered attention as a natural, calorie-free sweetener that can seamlessly replace sugar in various recipes. Derived from the leaves of the Stevia rebaudiana plant, this sweetener is known for its ability to provide a satisfying sweetness without the health drawbacks associated with traditional sugar. In this article, we'll explore creative recipes and practical tips for incorporating stevia into everyday cooking and baking, allowing you to enjoy your favorite dishes without compromising on taste.
Before diving into recipes, it's important to understand why stevia is a fantastic alternative to sugar. Here are some of the key benefits:
Stevia can effectively replace sugar in many baking recipes, but it's essential to remember that it is much sweeter than sugar. Typically, a teaspoon of stevia extract can replace a cup of sugar, but always refer to specific conversion charts provided by stevia product manufacturers.
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Beyond baking, stevia can introduce a hint of sweetness to savory dishes as well. Here are some innovative ways to include stevia in your everyday cooking.
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Stevia is also great for sweetening beverages. Whether it’s a refreshing iced tea or a nutritious smoothie, stevia can add the perfect touch of sweetness.
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Stevia opens up a world of culinary possibilities, letting you enjoy the sweetness of your favorite recipes without the drawbacks of sugar. From delectable desserts like chocolate chip cookies to savory innovations like homemade BBQ sauce, the versatility of stevia can enhance all your culinary creations. Remember, the key is to experiment and adapt recipes to suit your taste, making stevia a valuable and enjoyable part of your cooking repertoire.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6606)
Date:
May 29, 2024 11:28 AM
Vitamin B12, or cobalamin, is crucial for red blood cell production, DNA synthesis, and nervous system health. Among its many roles, one of the most vital is its contribution to energy production and metabolism. This article delves into how Vitamin B12 affects energy levels, with a particular focus on its importance for vegetarians and vegans.
Vitamin B12 is a water-soluble vitamin that is naturally found in animal products such as meat, dairy, and eggs. It is primarily responsible for converting food into ATP (adenosine triphosphate), which the body uses for energy. B12 is also crucial in the formation of red blood cells, which carry oxygen to every part of the body, and in maintaining the health of nerve cells.
Vitamin B12 is a key player in metabolism, a complex set of chemical reactions in our body that convert food into energy. One of the primary ways B12 contributes to metabolism is through its involvement in the Krebs cycle, a series of reactions that produce ATP (adenosine triphosphate), the body's primary energy currency. During the Krebs cycle, Vitamin B12 helps convert fats and proteins into energy, ensuring that the body has a constant supply of fuel to perform everyday tasks.
Vitamin B12 is also essential for DNA synthesis and cell division. It works closely with folate (Vitamin B9) to synthesize DNA during cell division. Rapidly dividing tissues, such as red blood cells, require an adequate supply of B12. A deficiency in this vitamin can lead to megaloblastic anemia, a condition where red blood cells are larger than normal and not as effective in transporting oxygen, thereby causing fatigue and weakness.
One of the significant challenges for vegetarians and vegans is getting enough Vitamin B12, as it is predominantly found in animal products. Plant-based diets generally lack this vitamin, putting individuals at risk of deficiency. However, several fortified foods and supplements can help prevent this deficiency.
Many plant-based milk alternatives, breakfast cereals, and nutritional yeasts are now fortified with Vitamin B12. For instance, a cup of fortified soy milk can provide about 50% of the daily recommended intake of B12. Additionally, B12 supplements are readily available and can be an effective way for vegetarians and vegans to ensure they get their daily dose. It's crucial to choose a supplement that meets the dietary needs and preferences of the individual.
A lack of Vitamin B12 can result in various health problems like fatigue, weakness, constipation, loss of appetite, and weight loss. In severe cases, it may lead to neurological issues such as numbness and tingling in the hands and feet, balance difficulties, depression, confusion, and memory loss. Given these risks, it's essential for vegetarians and vegans to monitor their B12 levels.
Adequate intake of Vitamin B12 can significantly enhance energy levels. Since B12 is involved in converting food into ATP, sufficient levels of this vitamin can help ensure that the body efficiently produces and uses energy. Individuals who maintain appropriate B12 levels often report feeling more energetic and less fatigued.
By ensuring a sufficient supply of B12, vegetarians and vegans can support their metabolic functions. A well-functioning metabolism is crucial for maintaining body weight, supporting muscle function, and ensuring overall vitality. Improved metabolic function also means better handling of the foods consumed, leading to more stable energy levels throughout the day.
Vitamin B12 is essential for producing neurotransmitters that regulate mood. Adequate levels of B12 can help prevent mental health issues such as depression and brain fog, which are often associated with fatigue and low energy levels. Regular intake of B12, either through diet or supplements, can contribute to better mental clarity and emotional well-being.
B12 is crucial in maintaining the myelin sheath, a protective coating around nerves. A healthy nervous system ensures that signals travel efficiently between the brain and the rest of the body. This not only helps in preventing neurological issues but also ensures that the body's energy systems operate smoothly.
For vegetarians and vegans, regular blood tests are an effective way to monitor B12 levels. These tests can help identify a deficiency early on, allowing individuals to take corrective measures before any severe symptoms manifest.
A well-rounded, balanced diet that includes fortified foods can help meet the daily recommended intake of Vitamin B12. Incorporating a variety of B12-fortified foods into every meal ensures a steady supply of this vital nutrient.
For those who struggle to get enough Vitamin B12 through diet alone, supplements are an excellent option.
When selecting a Vitamin B12 supplement, methylcobalamin, or methyl B12, is often recommended as the best form. It has superior bioavailability compared to cyanocobalamin, making it easier for the body to absorb and utilize. Methyl B12 doesn't need conversion in the body to be effective, leading to quicker uptake and immediate benefits. For vegetarians and vegans at higher risk of B12 deficiency, methyl B12 is especially beneficial for maintaining optimal B12 levels effectively. Including this form in your supplement routine can boost energy, mental clarity, and support metabolic and nervous system functions.
Raising awareness about B12 is key for vegetarians and vegans to prevent deficiencies. Health programs can educate on maintaining adequate levels through diet and supplements.
Vitamin B12's role in energy production and metabolism is indisputable. Vegetarians and vegans can struggle to get enough B12 from plant-based diets, but fortified foods and supplements offer solutions. Understanding B12's importance and taking action can boost energy, metabolism, and well-being. Regular monitoring, a balanced diet, and appropriate supplementation are key strategies to prevent deficiency and maintain optimal health.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6604)
Date:
November 10, 2022 11:23 AM
Probiotics are live bacteria that are good for your health, especially your digestive system. They can improve your gut health and even boost your immune system. But with so many different probiotics on the market, it can be hard to know which one to choose. That's where our new twelve-strain probiotic blend comes in. This blend contains over 20 billion living organisms, including B. lactis, B. bifidum, B. infantis, B. longum, L. acidophilus, L. brevis, L. bulgaricus, L. paracasei, L. planatarum, L. rhamnosus, L. salivarius and Streptococcus thermophilus—strains that have been shown to be particularly effective in supporting gut health.
But why take a probiotic? Probiotics can help to improve your gut health by restoring the balance of good bacteria in your gut microbiome. They can also help to reduce inflammation and alleviate symptoms of conditions like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Plus, taking a probiotic regularly can help to boost your immune system. So if you're looking for a probiotic that will support your overall health, our twelve-strain probiotic blend is an excellent option.
How the Twelve-Strain Probiotic Blend Works
When you take the twelve-strain probiotic blend, the live bacteria begin to work immediately—restoring balance to your gut microbiome and improving your gut health. The strains in the blend work together synergistically to provide the most effective results possible; for example, Bifidobacterium longum has been shown to increase the production of short-chain fatty acids (SCFAs), while Streptococcus thermophilus has been shown to reduce intestinal permeability (a common cause of inflammation). Together, these strains provide comprehensive support for gut health and immunity.
The Benefits of Taking the Twelve-Strain Probiotic Blend
There are many benefits to taking the twelve-strain probiotic blend on a regular basis. In addition to restoring balance to your gut microbiome and improving your gut health, the blend can also help to:
If you're looking for a probiotic that will support your overall health, our new twelve-strain probiotic blend is an excellent option. This potent blend contains over 20 billion live organisms—including Bifidobacterium longum, Streptococcus thermophilus, and other strains that have been shown to be particularly effective in supporting gut health—and it works immediately to restore balance to your gut microbiome and improve your gut health. Plus, the twelve-strain probiotic blend offers numerous other benefits, like reducing inflammation, boosting immunity, reducing anxiety and depression symptoms, and increasing weight loss. So if you're looking for a powerful probiotic that will support your overall health and well-being, our twelve-strain probiotic blend is an excellent option!
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Date:
October 21, 2022 12:12 PM
L-Histidine is an essential amino acid that plays a role in a variety of important bodily functions. Histidine is best known for its role in the production of histamine, an important mediator of immune system responses. However, histidine is also critical for normal brain function and for the maintenance of a healthy skin barrier. In addition, histidine plays important roles in muscle function, cardiovascular health, protection against free radicals, and the elimination of heavy metals from the body. Let's take a closer look at some of these benefits.
The Role of Histamine in the Immune System Response
As we mentioned before, histamine is an important mediator of immune system responses. When your body comes into contact with a foreign invader, such as a virus or bacteria, mast cells release histamine into the bloodstream. This leads to the dilation of blood vessels and increased permeability of capillaries, which allows white blood cells and other immune cells to more easily reach the site of infection. In addition, histamine release triggers sneezing and increased mucus production, which helps to expel foreign invaders from the body.*
Histamine and Brain Function
Histamine is also involved in regulating wakefulness and sleep cycles.* In fact, l-histidine deficiency has been linked to insomnia.* Histamine regulates serotonin levels in the brain and has been shown to improve cognitive function.* Additionally, histamine plays a role in memory formation and has even been shown to protect against age-related cognitive decline.*
L-Histidine and Cardiovascular Health
L-histidine has also been shown to have protective effects on the cardiovascular system.* Histamine promotes vasodilation—the widening of blood vessels—which can help to lower blood pressure.* L-histidine also inhibits platelet aggregation—the clumping together of blood cells—which can help to prevent blood clots from forming.* These effects can help to reduce the risk of heart attack and stroke.*
As you can see, l-histidine is involved in a variety of important bodily functions. From its role in immunity and brain function to its protective effects on the cardiovascular system, l-histidine is an amino acid that offers many benefits. If you are looking for a way to boost your health and well-being, consider adding l-histidine to your diet!
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Date:
October 07, 2022 10:26 AM
Feeling stressed? You're not alone. In today's fast-paced world, it's more important than ever to find natural ways to support our bodies in responding to stress. Introducing D-Flame, a carefully crafted blend of herbal extracts that may help to support a healthy response to physiological stress. Read on to learn more about the key ingredients in D-Flame and how they work together to keep your body operating at its best.
The Science Behind D-Flame
D-Flame contains a unique blend of botanical extracts that work together to support the body's natural response to stress. Here's a closer look at some of the key ingredients in D-Flame and how they contribute to its ability to promote a healthy stress response:
Holy Basil Extract - Holy basil is an ayurvedic herb that has been used for centuries in India for its many purported health benefits. Among these is the ability to help the body adapt to stress by supporting the activity of key stress mediators.
Ursolic Acid - Ursolic acid is a type of triterpenoid compound that is found in a variety of plants. It has been shown to possess anti-inflammatory and antioxidant properties, which may help to protect cells from damage caused by oxidative stress.
Turmeric Extract - Turmeric is a well-known spice with powerful antioxidant activity. Its active ingredient, curcumin, has been shown to modulate the activity of enzymes involved in inflammation, helping to keep inflammation levels in check.
Ginger Extract - Ginger has long been used as a natural remedy for digestive issues like nausea and indigestion. It also possesses potent anti-inflammatory activity, which may help to reduce pain and swelling associated with occasional overexertion or injury.
Green Tea Extract - Green tea is rich in antioxidants and polyphenols, which may help protect cells from damage caused by free radicals. It also contains caffeine, which has been shown to increase alertness and focus while also reducing fatigue.
Boswellin® - Boswellin® is an extract of the herb boswellia serrata that has been shown to inhibit the production of pro-inflammatory molecules known as leukotrienes. This action helps to reduce inflammation throughout the body.
Bromelain - Bromelain is an enzyme found naturally in pineapple that possesses powerful anti-inflammatory activity. It works by inhibiting the production of pro-inflammatory cytokines, helping to reduce inflammation and pain associated with conditions like joint pain and arthritis.
Baikal Skullcap - Baikal skullcap is an herb native to Southeast Asia that has traditionally been used as a remedy for digestive issues and skin ailments. It also possesses potent anti-inflammatory activity, which makes it ideal for alleviating occasional pain and swelling associated with injury or overexertion.
Resveratrol - Resveratrol is a type of phytonutrient that is found in grapes, berries, and other plant foods. It has strong antioxidant activity and has also been shown to modulate the activity of genes involved in inflammation, making it an effective tool for reducing chronic inflammation throughout the body.*
Berberine - Berberine is a bitter alkaloid compound that is found in a variety of plants including goldenseal, barberry, and Oregon grape root. It has powerful antimicrobial activity against bacteria, viruses, and fungi.* Additionally, berberine has strong anti-inflammatory activity, making it ideal for alleviating occasional pain and swelling associated with injury or overexertion.*
In Summary:
D-Flame is an all-natural blend of botanical extracts that have been traditionally used for centuries to support the body's response to stress.* These herbs work together synergistically to modulate key enzymes and mediators involved in inflammation.* This action helps reduce chronic inflammation throughout the body.* Additionally, these herbs also help protect cells from damage caused by oxidative stress.* If you're looking for an herbal supplement to help support your body during times of stress, look no further than D-Flame!*
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6487)
Date:
October 06, 2022 04:01 PM
Feeling stressed? You're not alone. In today's fast-paced world, it's more important than ever to find natural ways to support our bodies in responding to stress. Introducing D-Flame, a carefully crafted blend of herbal extracts that may help to support a healthy response to physiological stress. Read on to learn more about the key ingredients in D-Flame and how they work together to keep your body operating at its best.
The Science Behind D-Flame
D-Flame contains a unique blend of botanical extracts that work together to support the body's natural response to stress. Here's a closer look at some of the key ingredients in D-Flame and how they contribute to its ability to promote a healthy stress response:
Holy Basil Extract - Holy basil is an ayurvedic herb that has been used for centuries in India for its many purported health benefits. Among these is the ability to help the body adapt to stress by supporting the activity of key stress mediators.
Ursolic Acid - Ursolic acid is a type of triterpenoid compound that is found in a variety of plants. It has been shown to possess anti-inflammatory and antioxidant properties, which may help to protect cells from damage caused by oxidative stress.
Turmeric Extract - Turmeric is a well-known spice with powerful antioxidant activity. Its active ingredient, curcumin, has been shown to modulate the activity of enzymes involved in inflammation, helping to keep inflammation levels in check.
Ginger Extract - Ginger has long been used as a natural remedy for digestive issues like nausea and indigestion. It also possesses potent anti-inflammatory activity, which may help to reduce pain and swelling associated with occasional overexertion or injury.
Green Tea Extract - Green tea is rich in antioxidants and polyphenols, which may help protect cells from damage caused by free radicals. It also contains caffeine, which has been shown to increase alertness and focus while also reducing fatigue.
Boswellin® - Boswellin® is an extract of the herb boswellia serrata that has been shown to inhibit the production of pro-inflammatory molecules known as leukotrienes. This action helps to reduce inflammation throughout the body.
Bromelain - Bromelain is an enzyme found naturally in pineapple that possesses powerful anti-inflammatory activity. It works by inhibiting the production of pro-inflammatory cytokines, helping to reduce inflammation and pain associated with conditions like joint pain and arthritis.
Baikal Skullcap - Baikal skullcap is an herb native to Southeast Asia that has traditionally been used as a remedy for digestive issues and skin ailments. It also possesses potent anti-inflammatory activity, which makes it ideal for alleviating occasional pain and swelling associated with injury or overexertion.
Resveratrol - Resveratrol is a type of phytonutrient that is found in grapes, berries, and other plant foods. It has strong antioxidant activity and has also been shown to modulate the activity of genes involved in inflammation, making it an effective tool for reducing chronic inflammation throughout the body.*
Berberine - Berberine is a bitter alkaloid compound that is found in a variety of plants including goldenseal, barberry, and Oregon grape root. It has powerful antimicrobial activity against bacteria, viruses, and fungi.* Additionally, berberine has strong anti-inflammatory activity, making it ideal for alleviating occasional pain and swelling associated with injury or overexertion.*
In Summary:
D-Flame is an all-natural blend of botanical extracts that have been traditionally used for centuries to support the body's response to stress.* These herbs work together synergistically to modulate key enzymes and mediators involved in inflammation.* This action helps reduce chronic inflammation throughout the body.* Additionally, these herbs also help protect cells from damage caused by oxidative stress.* If you're looking for an herbal supplement to help support your body during times of stress, look no further than D-Flame!*
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6486)
Date:
September 24, 2022 10:26 AM
Pyruvate is a biochemical compound that’s involved in a number of metabolic processes in the body, including the metabolism of fat, proteins, and carbohydrates, the storage of glycogen, and the production of cellular energy.* Pyruvate is necessary for the citric acid cycle (or Krebs cycle), which is the process through which our cells produce energy in the form of adenosine triphosphate (ATP).* ATP is the body’s primary chemical fuel and powers many vital functions, including energy production, muscle contraction, and cellular fuel replenishment.* In short, pyruvate is essential for maintaining a healthy body. Let’s take a closer look at some of the specific ways in which pyruvate benefits the body.
The Role of Pyruvate in Metabolism
As we mentioned above, pyruvate plays an important role in metabolism—specifically, the metabolism of fat, protein, and carbohydrates. Pyruvate is involved in three different metabolic pathways: glycolysis (the breakdown of glucose), gluconeogenesis (the synthesis of glucose from non-carbohydrate sources), and the citric acid cycle (also known as the Krebs cycle or tricarboxylic acid cycle).*
The role of pyruvate in metabolism is twofold. First, pyruvate acts as an intermediary molecule in the conversion of glucose to ATP. Second, pyruvate initiates gluconeogenesis—the process by which glucose is synthesized from non-carbohydrate sources—by conversion into oxaloacetate.* This process occurs when there is not enough carbohydrate available for fuel or when additional glucose is needed for glycogen storage.*
The Benefits of Pyruvate Supplements
Pyruvate supplements have become popular in recent years as a weight loss aid.* Pyruvate has been shown to boost metabolism and promote thermogenesis—the process by which our bodies convert food into heat and energy.* In one study, participants who took 2.5 grams of pyruvate per day for six weeks lost significantly more weight and body fat than those who didn’t take pyruvate.* In another study, participants taking 3 grams of pyruvic acid per day for 12 weeks reduced their body fat mass by an average of 3.5 kilograms (7.7 pounds) compared to those taking a placebo.*
In Summary:
Pyruvate is a biochemical compound with a variety of functions in the human body. Most importantly, it plays a role in metabolism—specifically, the metabolism of fat, proteins, and carbohydrates. It also initiates gluconeogenesis—the process by which glucose is synthesized from non-carbohydrate sources—by conversion into oxaloacetate. Additionally, pyruvate has become popular in recent years as a weight loss aid due to its ability to boost metabolism and promote thermogenesis. Supplementing with pyruvic acid can help you lose weight and achieve your desired body composition.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6462)
Date:
April 29, 2022 12:41 PM
Heart disease is the leading cause of death in America, and myocarditis is one of the most common causes. Researchers are constantly looking for new ways to combat this deadly disease, and Delta-8 THC may be a promising treatment. A recent study found that Delta-8 was able to slow down heart rate and reduce inflammation in mice with myocarditis. While more research is needed, these findings suggest that Delta-8 could be a valuable tool in the fight against heart disease.
What is myocarditis and what are the symptoms?
Myocarditis is a term used to describe inflammation of the heart muscle. This can occur for a variety of reasons, including infection or injury, and it can cause a wide range of symptoms. Some of the most common signs of myocarditis include shortness of breath, chest pain, and chest tightness. Other possible symptoms include dizziness, lightheadedness, fatigue, nausea, and weakness. If you experience any combination of these symptoms along with changes in your heart rate or blood pressure, it is important to seek immediate medical attention to determine whether you are suffering from myocarditis. Treatment will depend on the specific cause of your condition, but it typically involves anti-inflammatory medications and rest. Early diagnosis and treatment are essential for preventing the progression of the disease and reducing the risk of cardiovascular complications.
What causes myocarditis and how is it diagnosed?
Myocarditis is a condition characterized by inflammation and swelling of the heart muscle. This can lead to a number of symptoms, such as shortness of breath, chest pain, increased heart rate, and cough. There are many possible causes of myocarditis, including infections, autoimmune disorders, metabolic or nutritional disorders, or exposure to toxins or other irritants. In order to diagnose myocarditis properly, doctors will typically perform several different tests. These may include blood tests, scans of the heart using ultrasound or MRI technology, and electrocardiograms to assess heart activity. Ultimately, the treatment for myocarditis will depend on its underlying cause and the severity of symptoms. With proper care, however, most people can recover fully from this condition.
How is myocarditis treated and what are the potential complications?
Myocarditis is a condition that occurs when the heart muscle becomes inflamed. This can be caused by a viral infection, an autoimmune reaction, or other factors. Treatment for myocarditis generally involves addressing the underlying cause, if possible. For example, if the inflammation is due to a viral infection, antiviral medications may be prescribed. Corticosteroids may also be used to reduce inflammation. In some cases, heart surgery may be necessary to repair damage to the heart muscle. Complications of myocarditis can include heart failure and arrhythmias. With prompt and appropriate treatment, however, most people with myocarditis recover fully.
What is Delta-8 THC and how does it work?
Delta-8 THC is a chemical compound that is found in the Hemp plant. Unlike other forms of THC, which produce psychoactive effects by binding to cannabinoid receptors in the brain, Delta-8 simply activates these receptors without producing any noticeable effects on cognition or perception. While the precise mechanism of action for this compound remains somewhat unclear, scientists believe that Delta-8 works by interacting with specific neuroreceptors in the brain and body, thereby triggering a series of responses that ultimately lead to changes in mood or behavior. Furthermore, research suggests thatDelta-8 may also have antioxidant properties and may be effective at reducing inflammation in certain tissues. Overall, while more research is needed to fully understand the pharmacological effects of this compound, it seems clear that Delta-8 has great potential as a therapeutic agent and may hold benefits for patients suffering from certain mood disorders or neurological conditions.
Delta-8, inflammation and relaxation
Delta-8 is a cannabinoid that is found in hemp plants. This compound has a similar structure to Delta-9 THC, the main psychoactive compound in cannabis. However, Delta-8 is much less potent than Delta-9 and does not produce the same psychoactive effects. Instead, Delta-8 provides a more mild physical response that is associated with relaxation and relief from anxiety and pain. Research suggests that Delta-8 may also be effective in reducing inflammation. This anti-inflammatory effect may be due to the ability of Delta-8 to bind to CB2 receptors, which are found in high numbers in the immune system. As a result,Delta-8 may offer a unique combination of anti-inflammatory and relaxant effects.
What are the findings:
The results of recent studies suggest that delta-8, a type of cannabinoid found in cannabis plants, may play a role in reducing the symptoms of myocarditis. Myocarditis is a condition characterized by inflammation and damage to the heart muscle, which can lead to serious complications such as cardiac arrest if left untreated. Early research has shown that delta-8 may be able to help protect against this deterioration, as it was found to reduce levels of oxidative stress and inhibit pro-inflammatory signaling pathways. As more studies continue to explore the mechanisms underlying myocarditis, it is hoped that delta-8 will become an important tool for managing this deadly disease.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6398)
Date:
April 29, 2022 11:33 AM
https://vitamins.vitanetonline.com/wp-content/uploads/liver-2934612_1920.png
What is the liver and what does it do?
The liver is a large, multi-functional organ that plays a vital role in the body. Its primary function is to filter the blood and remove toxins, but it also helps to regulate metabolism, store nutrients, and produce bile. The liver is divided into two main lobes, the right lobe and the left lobe. The right lobe is slightly larger than the left lobe and includes the quadrate lobe and caudate lobe. The left lobe contains the left lateral section and the medial section. The hepatic veins drain blood from the liver and pass it through the inferior vena cava to be returned to the heart. The hepatic arteries supply oxygenated blood to the liver tissue, while the portal vein carries nutrient-rich blood from the digestive organs. The bile ducts transport bile produced by the liver cells to the gallbladder, where it is stored until needed for digestion.
The liver is a hardworking organ that performs many crucial functions in the body. By keeping it healthy, we can help to ensure that our entire body remains healthy and functioning properly.
What can damage the liver and how does that damage occur?
The liver is a vital organ that performs many important functions, such as filtering toxins from the blood and producing bile to help digest fats. However, the liver can be damaged by a number of different agents, including viruses, alcohol, and certain medications. Viruses such as hepatitis C and hepatitis B can cause inflammation of the liver, which can lead to scarring and eventually to liver failure. Alcohol abuse is also a major cause of liver damage, as it can lead to fatty deposits, inflammation, and scarring. In addition, certain drugs (such as acetaminophen) can cause toxic damage to the liver cells. If the liver is not functioning properly, it can result in a build-up of toxins in the blood, which can lead to serious health problems.
Can the liver be repaired once it is damaged, and if so, how is that done?
The liver is a amazing organ. It is responsible for so many important functions in the body, from filtering toxins to producing bile to breaking down fats. When it is damaged, it can often repair itself. This is because the liver has a high regenerative capacity. hepatocytes, which are the main type of liver cell, can divide and grow back quickly when necessary. In fact, as long as about 25% of the liver remains healthy, it can regenerate itself completely over the course of a few weeks. There are a number of ways to damage the liver, such as through alcohol abuse or viral infections, but fortunately there are also ways to help it repair itself. Eating a healthy diet, getting enough exercise, and avoiding toxins, take liver supporting supplements like milk thistle and NAC can all support liver health and regeneration.
How can people prevent their livers from being damaged in the first place?
The liver is a vital organ that plays an important role in metabolism. However, the liver can also be easily damaged by alcohol, drugs, prescriptions, and environmental toxins, which are in the foods we eat. To help prevent liver damage, it is important to avoid excess alcohol consumption or avoid it all together, take medication as directed and if you are on medications that cause liver damage to discuss alternatives that do not harm the liver, and eat a healthy diet along with taking liver supporting supplements. Additionally, it is important to get regular exercise, as this helps to keep the liver healthy and functioning properly. By taking these steps, people can help to prevent liver damage and keep their organs healthy.
Are there any lifestyle changes or supplements that can help improve liver function even if it has been damaged already?
Liver damage is a serious concern for many people, as it can lead to a number of health problems. While there is no guaranteed way to reverse liver damage, there are some lifestyle changes and supplements that may help improve liver function. One potential change is to limit alcohol consumption, as alcohol is known to be damaging to the liver, mixing alchol and drugs can enhance the progress of liver damage. Additionally, eating a healthy diet and exercising regularly can help improve overall liver function. There are also a number of herbal supplements that are thought to be beneficial for the liver, such as milk thistle and dandelion root. However, it is important to speak with a healthcare provider before starting any new supplement, as some may interact with other medications.
What are the possible consequences of not repairing a damaged liver?
Liver damage can have serious consequences if left untreated. Depending on the cause, there may be a variety of negative effects that result from an injured liver. For example, if the damage is due to excessive alcohol consumption, then scarring and inflammation of the liver tissue can interfere with its ability to filter toxins out of the blood. This can lead to a host of potentially dangerous health problems, including nausea, chronic fatigue, jaundice, and cirrhosis. You must address the cause before change for the good can happen. In addition, unresolved inflammation can increase one's risk of developing more serious conditions such as cancer or heart disease. To prevent these possible consequences, it is important to seek medical attention as soon as possible after suffering from liver damage. This will allow doctors to properly diagnose the issue and develop an appropriate treatment plan. Addressing the cause is always preferable over simply treating symptoms alone. Ultimately, taking action now can help you protect your health in the future.
How can people find out if their livers need repair and where they should go for help if that is the case?
When it comes to liver health, there are a number of ways to find out if your liver needs some repairs. One method is to get tested for elevated liver enzymes, which are indicative of problems with the organ. You can also watch out for certain symptoms, such as fatigue, bloating or skin discoloration. If you notice any of these markers, you may want to consult with your doctor or a specialist in liver disease, who can help determine the best course of action. Depending on the underlying cause of your liver problem, treatment options may include changes to your diet and exercise habits, medications or even surgery in extreme cases. Whatever route you choose, it is essential that you address any issues with your liver as soon as possible in order to protect your overall wellbeing.
Generally, symptoms only show when liver function has dropped significantly.
Liver damage can often go undetected until it has reached a advanced stage. This is because the liver has an incredible capacity for regeneration and can continue to function even when up to 75% of it has been damaged. As a result, symptoms of liver disease often only become apparent when the organ has been severely compromised. By that point, the damage may be irreversible and serious complications may have developed. Therefore, it is important to be aware of the early signs of liver damage so that treatment can be started as soon as possible. These include fatigue, weight loss, abdominal pain, and yellowing of the skin and eyes.
Fortunately, Supplements like Milk thistle and NAC may help the body assist the liver in its repair.
The liver is a hardworking organ that is constantly exposed to toxins. As a result, it is susceptible to damage. Fortunately, supplements like milk thistle and NAC may help the body assist the liver in its repair. Milk thistle contains silymarin, a compound that helps to protect the liver from damage. NAC is an amino acid that helps to remove toxins from the liver. NAC also helps to replenish glutathione, a substance that plays a key role in liver detoxification. Together, these supplements can help to keep the liver healthy and functioning properly.
Whether you are looking for preventative measures to protect the liver or have an existing issue, it can never hurt to take either milk thistle, NAC, or both to support healthy liver function.
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Date:
May 15, 2019 02:34 PM
The elevated levels of insulin found in many people with obesity can elevate their risk of breast cancer, but new studies show that omega-3 free fatty acids can help mitigate this risk. Too much insulin can increase Akt and Erk1/2 phosphorylation, but omega-3s can help to reduce this effect. Likewise, omega-3 free fatty acids were able to cut down proliferation of MCF-7 cells. The research sheds some light onto why omega-3s appear to reduce the risk of breast cancer, although more research is needed. Key Takeaways: "Researchers found a link between consumption of omega-3s and reduced breast cancer risk by lowering insulin levels. The study, which was published in Nutrition Research, tested the ability of omega-3 free fatty acids (FFAs) to reduce insulin-induced breast cancer cell proliferation." Read more: https://www.naturalnews.com/2019-03-26-omega-3-can-reduce-high-insulin-levels-breast-cancer.html
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Date:
May 14, 2019 05:01 PM
It is noted that when one eats sweets before going to bed this could have a negative impact on his sleep. If one does not sleep well, the next day would be a dreadful one. But for those who want to indulge themselves at night with something sweet, there is a natural alternative they can go for which can also help them to sleep better at night. That alternative is honey. Honey is a potent superfood and effective for relaxation, and can serve as a sleep remedy. The use of honey is not new. For centuries, various cultures have used it for food and medicine. Honey is a good source of nutrition because it has lots of antioxidants and nutrients. It is also rich in natural compounds. Honey is recommended as a daily food and its does not have negative drawbacks no matter how often one takes it. Honey possesses many properties which include being an important alternative to sugar, for the treatment of insomnia, for the promotion of deep sleep, and for the relaxation of the body. Therefore, honey is recommended by health practitioners to be taken daily. Key Takeaways: "Eating honey at night can kick-start a whole chain of events throughout your body. Raw honey naturally contains high levels of fructose and glucose. Glucose can immediately boost your energy levels, whereas fructose gets stored in your liver as glycogen to serve as an energy source while you sleep." Read more: https://www.naturalnews.com/2019-04-18-eat-honey-to-help-you-sleep-better.html
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Date:
May 10, 2019 10:42 AM
Aloe vera can be used for plenty of skin conditions, but new evidence suggests it could be used for blood infections, because of the metabolites in the plant. A Chinese and Japanese study looked at this using mice, and found that aloe metabolites suppressed inflammation, due to reduced nitric oxide level. This is important because sepsis harms the body's own tissues and organs, and can be fatal. Aloe also has other uses, such as skin care, warding off cancer, treating digestive issues, and lowering blood sugar levels. Key Takeaways: "After using various tests to determine inflammation, the Chinese and Japanese research team found that aloe metabolites suppressed the expression of inducible nitric oxide synthase (iNOS) and mitogen-activated protein kinases (MAPKs). Aloe metabolites also decreased the production of proinflammatory cytokines and nitric oxide." Read more: https://www.naturalnews.com/2019-04-17-can-aloe-vera-be-used-to-treat-sepsis.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6300)
Date:
May 06, 2019 03:02 PM
In an emergency, there are some home remedies that can help mitigate the effects of burns. The first step is always to cool the burn by running it under cool water for at least 10 minutes. Aloe Vera can be applied to burns to help promote quicker healing and control inflammation. Bathing in oatmeal can help to reduce itching, especially when the burn begins to heal. Raw honey may also have antibacterial properties, while the tannins in witch hazel can reduce swelling and help repair your skin. Key Takeaways: "The injured skin is traumatized and using ice on the patient’s skin will constrict blood vessels and decrease blood circulation to an area that desperately needs it." Read more: https://www.naturalnews.com/2019-03-31-natural-home-remedies-for-burns.html
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Date:
May 03, 2019 04:06 PM
South African honeybush tea is made from a plant called Cyclopia intermedia and provides a diverse mix of health benefits. In addition to providing many important minerals, honeybush also contains a very wide range of antioxidants, including flavones, polyphenols, flavonoids and many others. It also contains compounds with expectorant and antimicrobial effects that can help ward off colds and other minor infections. Animal studies suggest honeybush tea also helps prevent your body from storing as much fat, and assist in burning the body fat you already have. Key Takeaways: "Drinking a cup of honeybush tea can provide the body with minerals such as calcium, copper, iron, magnesium, manganese, potassium, sodium, and zinc." Read more: https://www.naturalnews.com/2019-04-01-honeybush-tea-a-nutrient-rich-heart-healthy-drink.html
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Date:
April 25, 2019 04:48 PM
Insomnia, which is a chronic lack of sleep, achieved because the insomniac can't seem to enter a state of sleeping, or because the sufferer can't sustain the state once achieved, is a debilitating problem for many. While there exist pharmaceutical interventions for insomnia, there are also more natural ways to combat the problem, specifically food choices that may help. Tryptophan is the hormone that releases the relaxing chemical serotinin, that helps sleep arrive. Hummus has natural tryptophan. Kiwi has specific phtyochemicals and antioxidants that also promote sleep. Healthy carbs tend to make us sleep, which is why corn is a good sleep-promoter. Milk is another healthy carrier of tryptophan. Chewing on basil might help too as it eases mental woes and soothes troubled digestion. Key Takeaways: "The sugar level in candies is capable of upsetting your blood sugar levels which leads to the interruption of your sleep. You might sleep well immediately after eating them but after some time, you will wake up irritable. Corn is a healthy carb you should incorporate in your diet." Read more: https://www.longevitylive.com/live-healthier/5-foods-fight-insomnia/
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Date:
April 24, 2019 03:57 PM
With more and more consideration placed on ways to make you more healthy and physically well, there has been an increase in the holistic forms and natural remedies that have been implemented. In doing so, one interesting trend that is recently being discovered is that of pine bark, a more specific type, that is seen for heart health. By using this pine bark in different foods, it can decrease the risk of metabolic syndrome in individuals. Key Takeaways: "Disease-fighting OPCs in pine bark are not only antioxidant (helping to scavenge dangerous free radicals), but have anti-inflammatory, anticancer, anti-allergenic, antibacterial and anti-aging effects as well." Read more: https://www.naturalhealth365.com/pine-bark-heart-health-2823.html
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Date:
February 11, 2019 11:11 AM
Physicians typically prescribe patients mainstream pharmaceutical drugs called selective serotonin reuptake inhibitors (SSRIs), and cognitive behavioral therapy (CBT) as a way to treat obsessive-compulsive disorder (OCD), but new research is showing that another effective route may be available. Ashwagandha roots can be put into a powdered extract that can be combined with lactose in order to treat symptoms of OCD. A six week trial proved that after 30mg of ashwagandha each day, patients who suffered from anxiety noticed that their symptoms improved at the end of the trial. Key Takeaways: "Patients may finally get their obsessive-compulsive disorder (OCD) under proper control thanks to an ancient Indian herbal remedy." Read more: https://www.naturalnews.com/2019-01-09-natural-remedy-for-ocd-may-lie-in-ashwagandha.html
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Date:
January 27, 2019 04:33 PM
Vegan diets are something that is really in fashion right now. Years ago, very few people were following vegan diets. People did not pay much attention to it but now, due to social media and marketing, these diets are getting more and more hype. As a result, you should try to make sure you are getting all the nutrients you need when on this diet. It is only natural for there to be some kind of nutrient deficiency when on this sort of meal plan. Key Takeaways: "Following a vegetarian or (the stricter) vegan lifestyle is rewarding, but it also comes with some challenges. Foregoing meat means you lose out on a major source of protein, but the list below includes other Paleo meat-free sources of this crucial nutrient." Read more: https://www.naturalnews.com/2018-12-08-best-vegan-friendly-protein-sources.html
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Date:
January 13, 2019 04:10 PM
The Francis Crick Institute has published new research on the useful properties of cruciferous vegetables in protecting against pathogens that attack your gastrointestinal tract. According to this research, kale, broccoli, and cauliflower can all help reduce your susceptibility to inflammatory bowel diseases. They do this by helping to mitigate the effects of a compound called Cyplal, which can inhibit your body’s ability to use a separate substance called aryl hydrocarbon receptor (AhR). This is good because when Cyplal interferes with AhR, it can leave you more vulnerable to gut parhogens. Key Takeaways: "An article in The Francis Crick Institute news page reported that cruciferous vegetables are particularly beneficial when it comes to shielding the intestine from disease-causing microorganisms." Read more: https://www.naturalnews.com/2018-12-18-eating-cruciferous-greens-help-your-immune-system-fight-off-intestinal-pathogens.html
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Date:
January 12, 2019 08:38 AM
Apple cider vinegar has many known health benefits including lowering cholesterol and helping with weight loss. However, there are also benefits from using it for your skin instead of just ingesting it. Apple cider vinegar can fight skin infections, help reduce body odor and fight dandruff. If you have a sensitive area due to a sunburn or mosquito bite, apple cider vinegar can also provide soothing relief. This will speed up the healing process as you will not be tempted to itch the affected areas. Key Takeaways: "The uses and benefits of ACV don’t end there: it’s also very popular in the world of beauty." Read more: https://www.standardmedia.co.ke/lifestyle/article/2001304805/why-your-skin-needs-apple-cider-vinegar
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Date:
November 27, 2018 08:51 AM
Mainstream media likes to emphasize medicine as the solution to our modern health crisis, but often downplays diet's role. The western diet is the cause of many cardiac issues, and it makes sense that it is also the solution. Omega 3 fatty acids have been shown to lower your risk of heart disease and cardiac death. Specifically, the compounds EPA and DHA are linked to a reduction in risk. Supplementing your diet with EPA and DHA omega 3 fatty acids is a low risk option with no negative side effects. Key Takeaways: "A recent study published in the Journal of Clinical Lipidology has shown that omega 3 fatty acids can, and do, help reduce the risk of heart disease and cardiac death. Specifically, the compounds EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) were linked to an overall eight percent reduction in risk." Read more: https://www.naturalnews.com/2018-11-13-taking-epa-and-dha-omega-3s-reduces-your-risk-of-cardiac-death.html
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Date:
November 24, 2018 11:13 AM
There are a lot of myths out there that are associated with the preventing of cancer. People who have come out and stated that they have the cure are immediately shot back down to Earth when their findings reveal almost nothing. However, doctors think that cranberries are actually important when it comes to preventing cancer. They have used them on many different subjects and the results are good. Not only do they help in preventing cancer, they help combating other chronic disease also. Key Takeaways: "These not only support your immune system and cellular health, but they also help your body flush bacteria like E. coli from your urinary tract, which is why cranberry is often recommended for those prone to urinary tract infections." Read more: https://www.naturalnews.com/2018-11-15-cranberries-prevent-cancer-and-many-other-chronic-diseases.html
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Date:
November 23, 2018 08:51 AM
A lot of natural healing herbs are getting a lot more media attention than before. It is hard to understand why but in all reality, it comes down to the individual. Some individuals really like the idea of natural remedies and they swear by them. This healing herb from India has received good reviews but doctors are not sure how effective it can be for the masses. However, if something works for you, then do not change from it. Key Takeaways: "This medicinal herb can provide the body with a lot of benefits. Some examples include lowering blood sugar levels, improving brain function, reducing inflammation, and even preventing anxiety and depression" Read more: https://www.naturalnews.com/2018-11-13-5-reasons-why-ashwagandha-is-an-amazing-healing-herb.html
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Date:
October 30, 2018 09:51 AM
There are so many people out there that really struggle from natural allergies. They wake up some days, and due to the environment around them, they can immediately start coughing and sneezing. They are not sick but they are allergic to the natural environment. It is very bothersome to some people. If you want to get rid of these allergies, then you need to look into some of the natural remedies that are said to help people. Key Takeaways: "Anyone can develop this condition, which can be triggered by animal dander, feathers, plants, pollen, or other environmental elements." Read more: https://www.naturalnews.com/2018-10-25-natural-remedies-to-alleviate-nasal-allergies.html
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Date:
October 25, 2018 01:51 PM
The bottom line is that your diet is so important if you want to remain healthy. Many people do not realize how important diet is and what it can do for the physical nature of your body. You are in charge of putting the right fuel into your body and this can lead to some great health benefits. If you are looking to eat healthy, try some beetroots as they have been proven to be excellent for your health. Key Takeaways: "Researchers found that people who drank 8 ounces of beetroot juice daily lowered both systolic and diastolic blood pressure." Read more: https://www.standardmedia.co.ke/evewoman/article/2001299375/five-health-benefits-of-eating-beetroots
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Date:
October 12, 2018 07:52 AM
Research shows that pomegranate can reduce muscle spasms which also allows it to be treated for spasm related conditions including diarrhea. The rind of a pomegranate has chemicals which relieve muscle spasms, but research is still being done as to a safe dosage of this chemical. Other home remedies that can reduce muscle spasms include water, electrolytes, tea, massages and rest. If the situation is more severe, you should go visit a health professional immediately. Key Takeaways: "Past research has confirmed the spasmolytic properties – the ability to reduce or cease spasms – of pomegranate rind, but the exact mechanism was not made clear." Read more: https://www.naturalnews.com/2018-09-28-relieve-muscle-spasms-naturally-with-the-pomegranate.html
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Date:
September 07, 2018 09:52 AM
As medical advancements have seen immense growth and expansion in recent years thanks to new technologies and capabilities, many people are also learning about some of the downfalls of using pharmaceutical drugs to fix their ailments at every turn. Instead, many people have opted out to choose holistic and natural remedies for many basic ailments or issues, with one of the most popular ingredients being used for many ailments being that of the spice and root turmeric. Key Takeaways: "Some common foods found in your pantry can actually work as home remedies that heal common illnesses." Read more: https://www.hindustantimes.com/fitness/5-natural-home-remedies-to-cure-common-ailments-turmeric-for-joint-pain-to-lavender-oil-for-insomnia/story-6i0wNunvys698ARgBY7thJ.html
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Date:
September 04, 2018 09:53 AM
Saffron is not only a tasty spice highly valued to culinary chefs, but it also has anti-cancer properties, according to a recently published article. Not only does saffron kill cancerous cells, but it is also selective in which cells it kills, meaning it doesn't harm non-cancerous cells. Saffron, although expensive, also has many other benefits. It can fight depression, improve skin, balance hormones, combat stomach pain, and even give sexual activity a boost. Saffron is a highly valued spice for good reason due to it's contributions to overall health. Key Takeaways: "What’s more, these compounds display selective toxicity against cells; that is, they ultimately kill cancer varieties without harming normal ones." Read more: https://www.naturalnews.com/2018-07-31-saffron-can-be-used-as-an-alternative-cancer-treatment.html
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Date:
July 11, 2018 09:54 AM
The kumquat may be tiny but it is full of many important nutrients. By eating it, you can inject your body with a terrific source of fiber and vitamin C. From the orange family, kumquats offer a slightly sweet but sour flavor. It is packed with many beneficial ingredients like antioxidants, fiber, minerals and vitamins. In addition, the fruit can help a person with the shedding of weight and better digestive health and immunity. It can also lower your risk of getting cancer. Key Takeaways: "Rich in fiber, antioxidants, vitamins and minerals, the kumquat may help increase weight loss, enhance immunity and promote digestive health." Read more: https://draxe.com/kumquat/
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Date:
March 20, 2018 09:18 AM
With the recent loosening of regulations on medical and recreational cannabis, a number of new cannabis products have flooded the market. As a result, consumers are often confused about the different options out there and what they do. One of these is CBD, and there are a number of myths surrounding it. For one, many people believe that it is a pure sedative, which isn't true. Additionally, it is often thought that the source of CBD is irrelevant - also false. Key Takeaways: "Cannabidiol (CBD) is an exciting focus of medical research, popular media, and legislation related to cannabis. Its presence is becoming ubiquitous on the shelves of health food stores and search engine results for numerous medical conditions, but don’t believe everything you hear." Read more: https://www.leafly.com/news/cannabis-101/separating-cbd-facts-from-myths
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Date:
February 11, 2018 03:59 PM
The body is pretty amazing in how it can detect foes. The system is literally called "friend/foe" and it is the immune system's response to all bacteria. Researchers examined mice for a particular strand of bacteria known as Helicobacter hepaticus. This invader caused a response from T cells and immediately was acted upon as "foe." Specifically Th17 were the T cells that were able to kill the bacteria, but they have another which shuts this cell down when finding friendly ones, not causing the inflammation chain that it normally does. Key Takeaways: "Certain bacteria, such as those from the Helicobacter family, are generally considered helpful but can cause disease when genetic or environmental factors alter the normal balance." Read more: https://www.breakingnews.ie/world/heres-how-the-body-prevents-helpful-bacteria-from-causing-disease-827150.html
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Date:
January 30, 2018 03:59 PM
Coconut oil is becoming more and more seen as a superfood, not only for its health but its beauty purposes as well. Its health can be seen with its anti-bacterial qualities. There is also a link to cardiovascular health. In Polynesia, where the coconut is the main staple, rates of heart disease are incredibly low. You can also use it to replace many of the fats in your pantry, since it cooks well and even adds great flavor to coffee. Key Takeaways: "Coconut products, particularly coconut oil, have been used by certain populations around the world for millennia, and in places where coconut oil is consumed as part of the standard diet, people seem to thrive." Read more: https://www.healthnutnews.com/use-coconut-oil-daily/
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Date:
January 28, 2018 07:59 AM
Cannabidiol, or cbd, was recently passed as a legal substance by the Indiana House of Representatives. The bill does have a curious ride that the cbd must contain less than 3% thc, or the active ingredient in marijuana to be legal. There may still be hurdles as it heads to the Senate, but this is clearly good. The best evidence came from a man suffering from ALS, who said it didn't cure him but it did give him better days than without the drug. Key Takeaways: "A House committee passed legislation Wednesday to legalize cannabidiol, or CBD. The unanimously-approved bill takes a simpler approach to authorizing its use." Read more: http://indianapublicmedia.org/news/simpler-cbd-legalization-bill-clears-house-committee-138811/
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Date:
January 17, 2018 03:59 PM
B complex vitamins can solve many skin problems and help make hair healthy and lustrous. B complex includes Niacin (B3), Pyridoxine (B6), Biotin (B7), Folic Acid (B9) and Cobalamin (B12). These vitamins have been found to decrease or prevent eczema, hyper-pigmentation, acne, skin cancer, premature aging, vitilago, and dandruff. Hair follicle size also increases due to B complex. All of the B complex vitamins are present in a healthy diet containing a variety of fruits and vegetables. Where diet is lacking, B complex supplements can be used and are taken by millions of people. There are many health benefits not related to hair and nails that B complex provides. Be sure to get B complex vitamins daily to look and feel your best. Key Takeaways: "Dull, hair fall, lifeless hair and receding hairlines are problems that plague not only older people but also the youth of today." Read more: http://www.natural-health-news.com/how-does-vitamins-b-complex-work-on-skin-and-hair/
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Date:
January 03, 2018 11:59 AM
British scientists have discovered thag drinking beetroot juice can help repair muscle damage. It is recommended to drink it right after strenuous physical activity. In this scientific study some people were given beetroot juice anf some people were given a placebo with the same amount of calories as beetroot juice. The people who drank the beetroot juice had a quicker recovery than those who drank the placebo. The ones who drank the placebo experienced more muscle soreness. Key Takeaways: "The findings showed that the participants exhibited a 13 percent increase in power in muscles that extended to the knee at about two hours after drinking the beetroot juice with high nitrate levels." Read more: http://www.naturalnews.com/2017-09-24-beet-for-muscle-recovery-scientists-reveal-how.html
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Date:
December 31, 2017 07:59 AM
A lot more children in this day and age are experiencing more mental disorders that were previously only diagnosed to adults, such as depression. Many factors can be causing this. Social media is much too image focused. Academic pressures are higher than ever before. Prepackaged junk foods and fast food are causing children to have poor diets. As adults we have to be aware of all these issues and bolster children's confidence while counterattacking negative influences. Key Takeaways: "Instagram and Snapchat can have a detrimental impact on the mental health of young people." Read more: https://www.thealternativedaily.com/what-is-driving-the-epidemic-of-anxiety-and-depression-in-school-age-kids/
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Date:
December 06, 2017 03:59 PM
Legalizing cannabis is at the forefront of many media outlets today. Some celebrities like Pam St. Clement are stepping up and confessing their use of cannabis to help relieve the ailments they suffer from such as the polymalgia rheumatica that Pam has.
She uses CBD which is an oil derived from cannabis that does not make you high. A drop or two under her tongue daily gives her the relief she needs in her joints to be able to function in a more normal way that she has not enjoyed in years.
It could be very helpful to the legalize cannabis movement when stars stand up and promote the drug as a legitimate way to help with many ailments and diseases without resorting to other drugs such as steroids, Key Takeaways: "Pam, 75, stunned TV viewers last month by smoking cannabis with nuns and getting high on a bong while filming Gone To Pot: An American Road Trip ." Read more: http://www.mirror.co.uk/tv/tv-news/eastenders-star-pam-st-clement-11627621
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Date:
November 15, 2017 07:59 AM
Vitamin K is the latest of the vitamins being better understood in the body. The latest research indicates it's good for a variety of health concerns and even in age prevention. Vitamin K supports dental health, strong bones which are correlated with smooth skin, and even heart health. Although relatively new to mainstream media, vitamin K plays a vital role in the body. It is found in animal products, in high quantities in dairy and also in fermented and cultured food. Keep eating healthy to keep up your vitamin K. Key Takeaways: "K2 is vital for calcium regulation in the body, building strong bones and breaking down unwanted calcification." Read more: http://www.longevitylive.com/health-living/vitamin-k-your-new-superhero-for-a-healthy-living/
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Date:
November 01, 2017 12:59 PM
Osteoarthritis is a condition affecting many people and without a cure, the condition turns lives upside down. Fortunately for sufferers, osteoarthritis inflammation and pain can be reduced with many at-home, natural remedies you probably already have lying around. Turmeric happens to be one of the remedies that works wonders for anyone who uses it and is suffering from this painful condition. Immediate inflammation relief is just one of the many benefits you enjoy when using turmeric for inflammation reduction. Key Takeaways: "A recent study published in the Journal of Medicinal Food demonstrated that extracts of turmeric have a significant impact on the inflammation and pain associated with osteoarthritis." Read more: http://www.dailyherald.com/entlife/20171028/turmeric-may-reduce-inflammation-from-osteoarthritis
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Date:
October 30, 2017 01:14 PM
It's easy for me to believe that the elderly would benefit from cannabis. Considering the plant is useful for pain management and arthritis pain. While i was in favor of the first point, I wasn't sure of what to think of point two. The usual stereotype for a cannabis user is dad bod at best.
I do wish there was more studies done on the benefits of cannabis over prescription pain relief for elderly. With America going through an opioid epidemic, you can see instant and prolonged benefit from this issue. Younger patients could be introduced to cannabis from a medical standpoint immediately, and not need opioids at age 11 for an appendix surgery.
Endocannabinoids are apparently good for bone strength. Which is great for the elderly.
Again, chronic pain is relieved by cannabis. Dementia can also be treated with cannabis. And can be prevented by smoking as an adult.
Enjoying life doesn't mean smoking cannabis, but smoking cannabis makes life enjoyable. Key Takeaways: "Every day, Baby Boomers and seniors are discovering the many benefits of the natural herb, and they’re using it to combat the consequences of age" Read more: http://www.dopemagazine.com/8-reasons-grandparents-use-cannabis/
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Date:
October 06, 2017 12:14 PM
Joint pain is hard for many. It hurts and makes it hard to get things done. This drink can help, though, and if you suffer from joint pain you could notice how much better it is to have it lessened. There are medications for this but not everyone wants to take those. Some people are allergic to them or just don't like the ingredients. This drink will seem safter to those people so they might be willing to try it. Key Takeaways: "its high concentration of nutrients will help eliminate pain and inflamation almost immediately"
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Date:
October 03, 2017 01:14 PM
Some people might wonder if it is healthy to detox with salt. The world is going crazy about salt detox. If you are feeling itchy and bloated, then it may be time for a detox. A detoxification, or body cleanse is the process through which toxins are removed from your system. Water and juices and even meditation aids in this process. These toxins get into our system through food and many other ways as well. Key Takeaways: "Contrary to what the salt-water detox fanatics say, experts don’t recommend a saline cleanse at all!" Read more: http://www.thehealthsite.com/fitness/diet/is-it-healthy-to-detox-with-salt-k0917/
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Date:
September 26, 2017 09:14 AM
There is new hope for people that suffer from a leaky gut. Probiotics that are spore based have been found to improve gastrointestinal health. They are the answer to leaky gut syndrome. The researchers came to this conclusion thanks to study they did. Leaky gut syndrome can lead to things like fatigue and inflammatory skin diseases as well as food sensitivities. It is very important for people that are suffering from this to get help right away. Key Takeaways: "According to the results of the experiment, the probiotic brought about a 42 percent decrease in endotoxin levels, a 24 percent decrease in triglyceride levels, while endotoxin levels rose by 36 percent in the placebo group and triglycerides fell by five percent." Read more: http://www.naturalnews.com/2017-09-17-new-hope-for-leaky-gut-sufferers-spore-based-probiotics-found-to-improve-gastrointestinal-health.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5280)
Date:
August 26, 2017 09:14 AM
Not all cholesterol is bad. You hear the word and probably immediately think of a doctor's visit but there is actually a good type. If you need more of that you can eat almonds. These nuts are delicious and are also a great source of protein and other things your body needs. There are many reasons to add them to your diet and many great ways in which to do it. There are different almond products on the market. Key Takeaways: "Regularly eating almonds could boost levels of HDL cholesterol while also improving the way it removes cholesterol from the body, according to a new study." Read more: http://www.foodprocessing.com.au/content/prepared-food/news/eating-almonds-could-increase-good-cholesterol-874218761
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5179)
Date:
August 09, 2017 07:14 AM
Recently, apple cider vinegar has become a hot-button topic not only in the kitchen, but when health is being discussed. There have been studies where apple cider vinegar can be used to whiten teeth, manage acne, and promote one's digestive health. Counter theories against these state that the testing was done on animals, leaving doubt. The vinegar can also help people feel fuller, longer, therefore reducing the need to eat. To avoid any damage to the teeth, drink the vinegar with a straw. Read more: Apple Cider Vinegar: Treasure or Trash?
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Date:
July 27, 2017 09:14 AM
All of us have favorite foods, dishes, go-to condiments, that appear invariably on our plate. Whether it’s the easy-to-make no-fuss nature of the choice, the it’s ‘what my store carries appeal,’ or it just boils down to how our taste buds feel about it, we can get in nutrition rut.
Fortunately, it’s not that hard to start swapping items we use daily for other easy-to-use items that taste good, even often having a similar taste and texture to those items we already use. The plus is that the swapped in items are better for us. Better, because they’re higher, in things that matter, like protein, amino acids, fiber, vitamins and minerals, besides being lower in things we should want to avoid, like empty calories, trans fat, excess carbs, and more.
By swapping some things daily, such as trying cinnamon, or organic honey, over sugar, substituting plain, organic coffee for that latte, a veggie wrap, for that bread and meat sandwich, could have big overall benefits in reduced pounds, renewed energy and a better overall nutritional profile, making for a healthier you. Key Takeaways: "Coffee often gets a bad rap when in fact, quality coffee consumed in moderation can have some great benefits." Read more: https://www.healthnutnews.com/30-surprising-food-swaps-that-will-immediately-improve-the-health-of-every-organ-in-your-body/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5043)
Date:
July 20, 2017 04:14 PM
There are always new fads where weight loss is concerned. Everyone wants to find new things to try. They want things to be more modern. Maybe this is not the right outlook, though. Maybe they should look at what their grandparents did because things seemed to be easier then, though there were fads back then too. The fads weren't as easy to find, though. Sometimes looking at previous generations can help us solve health and other problems. Key Takeaways: "Research also shows timing and frequency of meals effected weight loss. One big meal and two smaller meals with no snacking works the best." Read more: http://www.wwl.com/media/audio-channel/did-our-grandparents-have-it-right-when-it-concerns-weight-loss
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5005)
Date:
June 26, 2017 05:14 AM
Allergies are a concern for many people, especially when spring and summer weather rolls around. But, what would you say if you could drink a delicious juice and almost immediately end all those allergies and the painful symptoms that come with it ? The idea might not be so far-fetched, as there is a new juice that promises to do just that. Read this information and learn important information about this incredible juice that you should consume. Key Takeaways: "Allergies are actually reactions of the organism in people with weak immune system"
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4885)
Date:
June 05, 2017 07:14 PM
This article, titled, "Steroid abuse, a ticking health time bomb" is about the risk of heart attack associated with steroid abuse. There has recently been an increase in steroid abuse among young men who are willing to risk their health to look good. Steroids can cause cardiovascular disease, including heart attacks. The article also outlines the warning signs of an impending heart attack. People should be aware of symptoms such as feeling tired for no apparent reason, along with shortness of breath. If you are at risk for a heart attack, preventative measure should be taken immediately. Read more: Steroid abuse a ticking health time bomb
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4777)
Date:
May 28, 2017 12:14 PM
A warning video in absolutely awful English followed by a robotic voice telling me Dr Oz approves of this banana tea recipe.There is this terrible still image on the screen that zooms in and out and changes colors throughout the video. The recipe is then shown on the screen in scrolling text followed by the voice saying that this recipe can be used as an alternative to sleeping pills. Then the voice tells me to subscribe to the channel (which I absolutely will not be doing) so I don't miss any future videos. It also tells me to share the video to social media. Key Takeaways: "Banana tea is an ideal drink for better sleep, it is quick and easy, tastes amazingly and is really effective."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4715)
Date:
May 14, 2017 06:44 PM
Bloat is a very uncomfortable feeling which can be caused by eating certain foods, by menstruation and by other things. It causes a feeling of pressure in the abdomen. It can be painful or just unpleasant to deal with. There is also gas sometimes which is embarrassing if you're around others. This talks about how to deal with this bloating naturally rather than taking a medication. Many prefer natural remedies and these are good ones. Read more: 5 Simple Ways to Naturally Relieve Bloating
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4616)
Date:
May 13, 2017 08:44 AM
Coconut oil has experienced a huge increase in sales and taken the media bystorm in recent years. coconut oil can be found not only in specialty health food stores, but at most local grocers as well. Diets high in MCTs (65% of coconut oil's makeup) have been shown to improve glucose tolerance and reduce body fat accumulation when compared to diets high in LCTs. MCFAs have also been shown to preserve insulin action in, and insulin resistance in rat studies. When compared with other fats, coconut oil contains 2.6% fewer calories. Keep in mind however that all high-fat foods and oils are calorically dense and simply adding in more calorically dense food to a diet already ample in calories is not likely to result in weight loss.According to the Academy of Nutrition and Dietetics, virgin coconut oil has potential antioxidant properties due to certain plant nutrients it contains called phenolic compounds. Key Takeaways: "MCT oil is associated with a whole host of health claims including weight loss, decreased risk of metabolic syndrome, lowered abdominal fat, lowered inflammatory markers, decreased triglyceride levels, and the ability to raise HDL (good) cholesterol." Read more: http://www.organicauthority.com/are-the-mct-oil-nutrition-and-health-claims-backed-up/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4603)
Date:
April 10, 2017 06:44 PM
We often think that the water in our home is safe. There are many people in the world that do not have access to clean water. Even if you live someplace that is consider safe for water you still need to have it tested. You should have your water tested for things like fluoride, lead, chlorine, PCB, DDT, and more. Its not hard to have your water tested. Simply call your city and see what you need to do. Read more: Why You Should Test Your Tap Water Immediately (And How To Do It)
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4392)
Date:
March 23, 2017 11:44 AM
The hemp industry may be coming to Lehigh Valley, Pennsylvania. Ironically, Pennsylvania was a hub of hemp cultivation until it became illegal in the 1950s. Now hemp is returning with about half of 16 upcoming research projects exploring industrial hemp slated to take place in this region. These research projects include using hemp in bio-manufacturing, erosion control, and using hemp to absorb toxins in soil. With all this new interest in hemp cultivation, it has the potential to become a big industry in Pennsylvania. Key Takeaways: "Lehigh will evaluate the use of hemp for erosion control and phytoremediation." Read more: http://www.lehighvalleylive.com/news/index.ssf/2017/03/lehigh_valley_at_center_of_new.html
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Date:
March 22, 2017 11:14 AM
You can drink caffeine in low doses in order to fall asleep. You do not need to take a large amount. This may not work for everyone. But, one person found that they could sleep easier and their life got a little bit better after they had some caffeine. The only way to know if it works, is to try it yourself. Key Takeaways: "drink caffine in low doses to fall asleep I feel really backwards. I've been around medicine, worked at a pharmacy, I've heard this before but never believed others who said it cause it seems impossible."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4258)
Date:
March 19, 2017 10:44 AM
Dr. Michael Mosley writes about an 8 week blood sugar diet that will help you lower your blood sugar the natural way. Almost every physician recommends diet and exercise as the first line of defense in beating diabetes. This book gives you a great program to get your blood sugar under control through diet and exercise so you can avoid the nasty side effects that come from the medications that are used to treat diabetes. Read more: The 8-Week Blood Sugar Diet
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4217)
Date:
March 17, 2017 11:44 AM
Chronic depression should not be left untreated. Cost of treatment is a real concern, particularly if you are uninsured or unable to meet high deductibles. Fortunately, there are alternatives. Look for the free or low cost resources in your community. Community counseling services or support groups are some examples of low cost or free access to help. Self helps in the form of journal writing or meditation should be considered. Take advantage of sunlight, exercise, and a balanced diet. Finally, know the number for a national crisis hotline and recognize help is waiting for your call. Key Takeaways: "Some universities across the nation offer community counseling services with graduate students in their psychology departments." Read more: http://www.thealternativedaily.com/natural-ways-to-treat-depression/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4191)
Date:
March 03, 2017 02:59 PM
If you're looking for ways to prevent winter colds and the flu, your first step should be a visit to your local grocery store. Feeding your body certain foods may help to keep your immune system running strong. Plan your meals to include the following powerful immune system boosters. You may increase everyone’s chances of fending off those winter bugs before they get sick. Key Takeaways: "Usually, your immune system does an excellent job of protecting your body against disease-causing microbes. However, sometimes bacteria or viruses can slip past your body’s defense line." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4065)
Date:
February 17, 2017 10:59 AM
With marijuana now legal in 26 states and the District of Columbia, the cry for more research on cannabis oil has spread. Many are pushing for the use of cannabis oil, which is a potent form of the plant, to treat cancer and seizures. Though the use of the oil to treat symptoms of diseases is not currently supported by the FDA, some cases have shown success in relieving pain, preventing seizures, and slowing down cancer tumors. It’s important to get use a trustworthy source and start with small doses until you know how you will react. Key Takeaways: "Nausea is one of the most common reasons people turn to medical marijuana; synthetic THC has been administered to battle nausea in the UK since the early 80s, and many cancer patients choose to smoke marijuana to battle the effects of chemotherapy treatments." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3961)
Date:
February 16, 2017 10:59 AM
There are a lot of shocking stories in the news but CBS news may have topped all of them. CBS news appeared completely baffled while reporting on a story about a man whose cancer was cured through the use of cannabis oil. With more and more states pushing for cannabis to be legal in the United States more news has come out about its health benefits. Key Takeaways: "The only reason that marijuana isn’t already legalized is that the federal government profits far too heavily from the alternatives." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3954)
Date:
February 04, 2017 02:59 PM
It has been discovered that Cannabinoids can treat persistent inflammatory pain. This is according to new research that has been published in the journal of neuroscience and it was also published online. The researchers say their data shows how it can help. There are also other studies done that have shown the same thing. Key Takeaways: "This study joins a list of dozens that have shown that cannabinoids can treat and prevent inflammation, including one released just last month in the FASEB Journal which found that cannabis may treat chronic inflammation." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3883)
Date:
February 03, 2017 10:19 AM
We all know there are many foods and beverages that aren't good for you. But did you know that there are 12 foods you should never eat? You might be surprised by some of the items in this list. Find out what these foods are and why they should be removed from your diet immediately. Key Takeaways: "Heating juice denatures the chemicals makeup of vitamins and minerals and unless it is truly raw it is little more than flavored fructose."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3874)
Date:
February 01, 2017 10:59 AM
The United States is not the only place where marijuana plant products are under fire. Even in Australia, it is nearly impossible to get CBD oil for treatment of medical conditions such as epilepsy. One particular case in Australia is gaining media attention. It is the case of 5-year-old Katelyn whose grandfather has been giving her CBD oil to help with her Dravet Syndrome seizures. Her grandfather is under threat of being arrested, but he says it is worth it if he gets his family better access to a drug that will greatly help with her condition. Key Takeaways: "A millionaire philanthropist has taken hemp oil on national television to highlight his granddaughter's struggle to get treatment for her epilepsy, as the five-year-old-girl begs prime minister Malcolm Turnbull and state premiers to make medicinal cannabis more accessible." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3865)
Date:
January 26, 2017 02:59 PM
CDB is a cannabis compound that does not contain any THC, making some believe it is good. There have been some confusing reports recently in the British media about a compound in cannabis called CBD and how it has been reclassified as medicine. There are many facts and myths about it, but most importantly it is not weed, and has many uses. Key Takeaways: "In the UK it has been possible to buy CBD as a nutritional supplement. But last October, the Medical Healthcare Regulatory Agency decided to recognise CBD’s therapeutic benefits and reclassify it as medicine." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3832)
Date:
January 25, 2017 12:59 PM
The research, carried out at the University Hospital Basel, was published, Jan. 16, in the journal Nature Immunology, and addresses the series of reactions taking place in the human body, both for healthy and overweight people. When it comes to people who suffer from diabetes, this substance causes chronic inflammation, thus killing the cells responsible for the production of insulin. IL-1 and insulin increased the uptake of glucose into macrophages, and insulin reinforced a pro-inflammatory pattern via the insulin receptor, glucose metabolism, production of reactive oxygen species, and secretion of IL-1 mediated by the NLRP3 inflammasome, noted the research. Key Takeaways: "However, this new research presents the positive aspects of this type of inflammation triggered by digestion, as it seems that healthy people only have a short-term inflammatory response, directed at leveling the sugar uptake and the immune system." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3827)
Date:
January 23, 2017 10:59 AM
As Marijuana becomes more and more legal across the states, its plant leaves are becoming more popular tool. Oil from the leaves ,CBD oil, also has many great properties. It an affect the way you sleep helping you get a better nights rest. It also been known to change our mood and relieve your pain without any psychoactive properties. One of the most noteworthy reason to incoroporate this oil into daily life because it can help with cancer. It inhibits cell growth and manage seizures. The oil can be found all over as it is legal. Key Takeaways: "First off, don’t confuse CBD oil with hemp oil — a nutritional oil more properly known as hempseed oil. Made from crushing hempseed or hemp hearts, hemp oil is very rich in linoleic and alpha-linoleic acids and antioxidants, and it has an optimal ratio of omega-6 to omega-3 fatty acids." Reference: Always Stick with name brand CBD like Leaf Therapeutics
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3818)
Date:
January 22, 2017 02:59 PM
High doses of vitamin c can kill cancer cells. In the past cancer therapy through vitamin c has not always proven that effective. However, that is because they were trying to get people to ingest it through the mouth. the key is to let hit the bloodstream immediately. The Vitamin C selectively kills the cancerous cells and not the normal cells. This is because normal cells are smarter and handle the hydrogen peroxide better. Key Takeaways: "Normal cells have several ways to remove hydrogen peroxide, keeping it at very low levels so it does not cause damage. The new study shows that an enzyme called catalase is the central route for removing hydrogen peroxide generated by decomposing vitamin C." Reference: https://www.sciencedaily.com/releases/2017/01/170109134014.htm
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3816)
Date:
January 19, 2017 10:26 PM
There are mainly two different types of diabetes - Type 1 diabetes and Type 2 diabetes.
Type 1 diabetes is known as insulin-dependent or juvenile diabetes. It is a condition in which there is an absolute lack of insulin. Due to the attacking of the body's immune system, the beta cells which are present in the pancreas and are responsible for making and secreting insulin die. Thus, there are no cells available to make insulin. So, in this case, the body will die without getting supplemental insulin immediately or in near- immediate future. The only treatment for this diabetes is insulin shots. Almost 10% of the people get this diabetes.
Whereas in type 2 diabetes, beta cells are present therefore insulin is also present. This diabetes is also known as non-insulin dependent diabetes. Insulin production produced is less than the amount of insulin the body requires. Almost 90% get affected by this type of diabetes. Treatment includes proper diet, exercise, and pills.
Usually, type 1 diabetes starts during childhood whereas type 2 diabetes is usually diagnosed during adulthood. As type 1 diabetes affects mostly young babies and children, it is known as juvenile-onset diabetes. People who have type 1 diabetes lack total insulin whereas type 2 diabetics have too little insulin.
Even the causes of type 1 and type 2 diabetes are entirely different. It is not possible to prevent type 1 diabetes whereas type 2 can be avoided. But type 2 diabetes may be genetic also. It may be the result of obesity or high blood pressure. The symptoms of type 1 diabetes are very severe. Suddenly the child becomes feeble and sick; urination is increased, experience increased thirst, nausea, vomiting, stomach and abdominal pain, excessive fatigue, weight loss and decreased appetite. Immediate medical attention or usually hospitalization is required for the person suffering from these symptoms. On the other hand, type 2 is often diagnosed before the presence of any symptoms.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3804)
Date:
January 11, 2017 01:39 PM
Nuts are a proven healthy food. There are ways to enjoy the benefits of eating nuts in a way that makes them more enjoyable to eat then just eating them whole. You can enjoy them roasted eating them that way or srinkling on food, you can grind them and add to porridge, you can also bake them into pastries or blend them into healthy smoothies, all excellent ways to enjoy the health benefits of nuts. Key Takeaways: "No one said mandazis and chapatis can only be used made interesting using carrots and pumpkins alone."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3769)
Date:
January 04, 2017 10:37 PM
Free radicals are of good concern to any individual who wants to stay healthy. You have possibly heard of how hazardous these substances are and how essential are antioxidants that battle them. Understanding free radicals involves mastering just a little bit about their chemical background. Your body is made up of numerous connected parts. The organs and tissues that form these parts are all made from cells. In original terms, each cell is an independent unit that processes its waste and ingests nutrients, additionally to performing several other functions. Rust reactions occur since the oxygen in moisture has a charge. Though water is a complete molecule, its unbalanced, or polarized, form means that it tends to react, coming apart easily to leave charged oxygen behind. This oxygen joins with the metal molecules inside your body just as simply as it does those in a piece of iron. When your body could not become a rusted hulk of an old ship, it undergoes internal alterations. Related Products
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Date:
January 01, 2017 01:59 PM
New mothers, college students and emergency room doctors all have something in common: sleep deprivation. But is getting little to no sleep on a regular basis bad for your health? The evidence says yes. According to a recent study, getting less than three hours of sleep within twenty-four hours causes increased strain on the heart, elevated blood pressure, and increased heart rates. Thyroid hormones and cortisol also went up, which can lead to stress and eventually heart disease. It is clear that getting enough sleep is in your best interests in the short- and long-term, along with a healthy lifestyle. Key Takeaways: "Getting less than three hours of sleep during a 24-hour period causes immediate heart problems, according to a new study presented at the annual meeting of the Radio logical Society of North America. Researchers looked at 20 healthy adults." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3728)
Date:
December 29, 2016 07:59 AM
Inflammation and autoimmunity are caused by inappropriate activity of the body's own regulatory T immune cells. A mutation in a gene called Foxp3 causes a fatal disease, IPEX syndrome, where these cells run amok. But new research shows an unexpected link to the gut: Foxp3 mutant mice end up missing a particular type of bacteria from their intestines. By replacing the missing bacterial species in the gut microbiome, many of the T cell-mediated inflammatory symptoms could be improved. Key Takeaways: "The study, published online in The Journal of Experimental Medicine, suggests that replacing the missing gut bacteria." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3715)
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DLPA (DL-phenylalanine)
The liver is a vital organ in the body that performs many essential functions. It can be damaged by a variety of factors, including disease, alcohol abuse, and exposure to toxic chemicals. Once the liver is damaged, can it be repaired? In this article, we will explore the answer to that question. We will also discuss the various ways that the liver can be damaged and how those damages can be repaired. 
