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Date: September 14, 2026 11:22 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: NSAIDs vs. Curcumin: Which One Relieves Joint Pain Without Stopping Healing?

Comparative Analysis of NSAIDs versus Curcumin in Musculoskeletal Tissue Repair

Primary Biological Mechanisms and Pharmacological Targets

The functional divergence between these two compounds becomes clear when considering an intuitive mechanical analogy. Tissue trauma resembles damage to a commercial building, where initial inflammation functions as the construction and demolition crew tasked with clearing rubble, stabilizing the foundation, and laying down fresh structural framing. NSAIDs function like abruptly cutting electrical power to the entire work site: the noisy machinery stops instantly and the immediate disturbance ceases, but the construction workers lose the power necessary to clean the debris and erect permanent walls. Conversely, curcumin operates as an experienced site manager: it silences unnecessary chaos and prevents site vandalism while ensuring that the skilled workers - specifically chondrocytes in cartilage and tenocytes in tendons - remain fully active, supplied, and capable of completing the restoration.   

At the cellular level, NSAIDs exert their effects through the catalytic inhibition of cyclooxygenase enzymes, categorized as constitutive cyclooxygenase-1 (COX-1) and inducible cyclooxygenase-2 (COX-2). Membrane phospholipids damaged during injury release arachidonic acid, which COX enzymes convert into pro-inflammatory lipid mediators known as prostanoids, most notably prostaglandin E2 (PGE2). Nonselective NSAIDs block both isoforms, while selective coxibs specifically target COX-2. By shutting off PGE2 production, NSAIDs rapidly elevate pain thresholds and blunt localized swelling. However, because PGE2 also functions as a vital signaling cue for cellular recruitment, angiogenesis, and cellular proliferation, this total enzymatic shutdown strips local repair cells of the baseline signals required to orchestrate tissue regeneration.   

Curcumin avoids this indiscriminate pathway paralysis by acting upstream on master transcriptional control switches rather than directly neutralizing isolated enzymes. Its primary therapeutic mechanism centers on the inhibition of Nuclear Factor-kappa B (NF-kB) and Activator Protein-1 (AP-1) signaling networks. Under acute stress or chronic inflammatory loads, the NF-kB protein complex is released from its cytoplasmic inhibitor, IkBa, and translocates directly into the cell nucleus, where it drives the transcription of catabolic cytokines such as interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-a), and interleukin-6 (IL-6). Curcumin blocks the phosphorylation and degradation of IkBa, effectively keeping NF-kB trapped in the cytoplasm. By preventing this nuclear entry, curcumin attenuates the expression of pro-inflammatory cytokines and downstream matrix-degrading enzymes while preserving baseline physiological functions. Furthermore, curcumin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) pathways, which upregulate endogenous cellular antioxidants to neutralize destructive reactive oxygen species (ROS) that induce cell death in injured joints.   

The Mechanisms of NSAID-Induced Inhibition in Cartilage and Tendon Repair

Cartilage maintenance depends on chondrocytes, the sole cell type residing within articular joints, which are responsible for generating and maintaining the extracellular matrix of Type II collagen and water-binding proteoglycans such as aggrecan. Because adult articular cartilage lacks a direct vascular network, major defect repair relies heavily on the recruitment and chondrogenic differentiation of subchondral mesenchymal stem cells (MSCs) through endochondral ossification. Experimental evaluations demonstrate that systemic or intra-articular NSAID exposure halts this regenerative differentiation. Both nonselective NSAIDs and selective COX-2 inhibitors interfere with chondrocyte maturation and prevent successful tissue integration following cartilage transplantation or microfracture procedures.  At the cellular level, common NSAIDs - including indomethacin, ketorolac, and diclofenac - induce cell cycle arrest in chondrocytes by blocking transition from the resting G0 phase to the proliferative G1.

phase, substantially reducing viable cell numbers. Concurrently, NSAIDs downregulate Bone Morphogenetic Protein-2 (BMP-2), an essential anabolic signaling molecule that orchestrates matrix synthesis. Histological analyses in animal models reveal that NSAID administration causes a marked loss of extracellular proteoglycan content and widespread chondrocyte depletion, yielding elevated modified Mankin scores that signify advanced structural degeneration. In layman's terms, proteoglycans serve as water-absorbing structural sponges that grant cartilage its elastic shock absorption. When NSAIDs deplete these molecules, the joint surface dries out, becomes brittle, and rapidly wears down under routine mechanical friction.   

Tendon healing is similarly susceptible to disruption by NSAIDs. Tendons operate as high-tensile structural cables composed of longitudinally arranged Type I collagen fibers, maintained by specialized fibroblasts termed tenocytes and tenoblasts. Healing after acute rupture or chronic tear progresses through an initial inflammatory phase, followed by a proliferative phase of cell migration, and culminates in a lengthy remodeling phase of collagen alignment. In vitro and in vivo studies establish that NSAIDs directly suppress the migration and proliferative capacity of tenocytes during the critical early healing window. Without an adequate cellular workforce migrating into the wound bed, provisional collagen scaffolding cannot be synthesized effectively.   

The disruption is particularly pronounced at the enthesis, the specialized fibrocartilaginous junction where soft tendon inserts into rigid bone. Re-establishing this transition zone requires coordinated bone remodeling and chondrogenic differentiation, both of which are hindered by COX inhibition. In animal rotator cuff repair models, early administration of NSAIDs significantly delays collagen fiber organization and impairs mechanical integration at the insertion site, resulting in a measurable decline in load-to-failure strength and overall tendon toughness. Furthermore, while prolonged inflammation contributes to pathological degeneration, the transient synthesis of PGE2 during the initial hours following injury is essential for regulating localized microvascular flow and hyperemic nutrient delivery. By eliminating this early prostanoid pulse, NSAIDs starve the repair zone of oxygen and circulating factors precisely when the cellular metabolic demand is highest.   

Beyond direct biochemical cytotoxicity, systemic NSAIDs introduce a physical hazard known as analgesic arthropathy. In musculoskeletal biomechanics, pain functions as a protective feedback mechanism, forcing the patient to unload an injured joint or limb to prevent structural overload. By effectively blunting the pain reflex while simultaneously undermining the cellular synthesis of proteoglycans and collagen, NSAIDs create a deceptive state of perceived recovery. Patients prematurely resume unrestricted weight-bearing and strenuous activity, placing substantial, uncompensated mechanical forces onto compromised cartilage surfaces and unhealed tendon fibers. Over time, this recurring mechanical trauma accelerates joint space narrowing, promotes microfractures in the subchondral plate, and hastens functional joint breakdown.   

Chondroprotective and Tenogenic Mechanisms of Curcumin

In articular cartilage, curcumin acts as a direct chondroprotective agent by dismantling the catabolic cascade induced by pro-inflammatory cytokines. When joint tissues are exposed to elevated IL-1ß and TNF-a, chondrocytes are provoked to synthesize matrix metalloproteinases - specifically collagenases such as MMP-1, MMP-3, and MMP-13 - along with aggrecanases like ADAMTS5. These enzymes function like enzymatic shears, systematically slicing through structural Type II collagen strands and degrading aggrecan cores. Curcumin suppresses the transcription and secretion of MMP-1, MMP-3, MMP-13, and ADAMTS5 by neutralizing NF-kB and AP-1 activation. Concurrently, it upregulates Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2), an essential transcriptional regulator that represses matrix metalloproteinases at the genomic level.   

In addition to halting extracellular degradation, curcumin protects chondrocytes from inflammatory apoptosis. Exposure to oxidative stress and inflammatory cytokines typically triggers programmed cell death by activating the intrinsic caspase cascade. Curcumin suppresses this apoptotic pathway by reducing the cleavage of executioner caspase-3, downregulating the pro-apoptotic factor Bax, and elevating anti-apoptotic Bcl-2 expression. Microscopic and histological analyses of osteoarthritic cartilage treated with curcumin consistently show robust Safranin O staining, intact surface regularity, preserved chondrocyte density, and significantly reduced Osteoarthritis Research Society International (OARSI) degradation scores.   

Within tendon biology, curcumin promotes active tissue regeneration (tenogenesis) rather than inert scar formation. In animal models of tendon rupture and surgical repair, curcumin guides tendon-derived stem and progenitor cells (TSPCs) toward mature tenocyte differentiation. This lineage-specific differentiation is orchestrated primarily through activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and Wnt/ß-catenin signaling cascades. As stem cells commit to the tenogenic pathway, they significantly upregulate crucial structural and phenotypic markers, including epithelial cell adhesion molecule (EpCAM), tenomodulin, and the master tendon transcription factor Scleraxis.   

Through this guided differentiation, curcumin supports the preferential synthesis and organized deposition of high-tensile Type I collagen fibers, the primary architectural building blocks of healthy tendons. Injured tendons typically fill with disorganized, loose Type III collagen, which forms a structurally inferior, compliant scar. Curcumin supplementation promotes the progressive maturation from primitive Type III collagen to densely packed, parallel Type I collagen fibrils, restoring native tensile strength and mechanical breaking force.   

A major clinical challenge following tendon surgery is the development of peritendinous adhesions, in which excessive fibrotic scar tissue binds the healing tendon to its synovial sheath, restricting range of motion and joint gliding. Postoperative tendon repair involves a balance between extrinsic healing (in which exterior fibroblasts infiltrate the defect and deposit messy scar tissue) and intrinsic healing (in which tenocytes within the tendon substance reconstruct the matrix). Curcumin suppresses excessive peritendinous inflammation and extrinsic fibrosis while accelerating intrinsic tenocyte repair. Biomechanical testing confirms that local or systemic curcumin administration yields lower adhesion scores, increased gliding distances, and superior functional mobility without sacrificing structural load-bearing capacity.   

Comparative Clinical Efficacy and Systemic Safety Profiles

In randomized, active-controlled clinical trials of knee osteoarthritis, optimized curcumin preparations have demonstrated clinical pain reduction and functional recovery comparable to standard therapeutic doses of NSAIDs. In a randomized, open-label parallel-arm study evaluating 139 patients with symptomatic knee osteoarthritis, subjects received either 500 mg of a bio-enhanced curcumin extract three times daily or 50 mg of diclofenac sodium twice daily for 28 consecutive days. Patients treated with curcumin demonstrated comparable improvements in pain intensity on the Visual Analogue Scale (VAS) and functional scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) at days 14 and 28, showing no statistically significant difference in therapeutic efficacy compared to diclofenac.   

However, the systemic tolerability profiles between the treatments diverged markedly. Overall adverse events occurred in only 13% of the curcumin group compared to 38% of the diclofenac cohort. In the diclofenac arm, 28% of patients developed dyspeptic symptoms severe enough to require concurrent treatment with H2-receptor antagonists or proton pump inhibitors to prevent mucosal ulceration, whereas no patients in the curcumin cohort required gastroprotective intervention. Furthermore, the curcumin cohort experienced a significant reduction in flatulence and digestive discomfort, demonstrating beneficial gastric and intestinal cytoprotective effects.   

These safety observations are consistent across broader systematic reviews and meta-analyses. Nonsteroidal anti-inflammatory agents inherently compromise gastrointestinal integrity by systematically depleting cytoprotective prostaglandins, leaving the gastric epithelium vulnerable to acid erosion and hemorrhage. In addition, systemic inhibition of renal and vascular COX enzymes by NSAIDs reduces renal perfusion and disrupts the balance between prostacyclin and thromboxane, elevating the risk of fluid retention, hypertension, and adverse cardiovascular thrombotic events. Curcumin does not suppress these physiological prostanoid pathways, making it free from ulcerogenic, nephrotoxic, and cardiotoxic properties at therapeutic dosages.   

A longstanding limitation of standard curcumin supplementation in clinical settings has been its low oral bioavailability. Native curcuminoids are highly lipophilic, poorly soluble in aqueous gastric fluids, and subject to rapid hepatic and intestinal phase II metabolism into inactive glucuronides and sulfates, leading to swift biliary and fecal excretion. Consequently, raw culinary turmeric powders struggle to achieve the therapeutic systemic circulating concentrations required to reach poorly vascularized joint and tendon compartments. Modern pharmacognosy has addressed this pharmacodynamic hurdle through advanced delivery formulations. Modern strategies - such as co-administration with the natural alkaloid piperine (which inhibits hepatic glucuronidation), micellar dispersions, phytosomal phospholipid complexes, and bio-enhanced submicron dispersions - elevate systemic blood bioavailability by ten- to thirty-fold compared to unformulated extracts. These modern delivery platforms ensure that therapeutic concentrations reach synovial fluid, subchondral bone, and fibrous tendon sheaths without requiring excessive oral dosing.   

Conclusions and Translational Clinical Implications

In contrast, curcumin provides a tissue-preserving alternative that decouples pain and inflammation control from cellular suppression. Operating upstream at the level of NF-kB and AP-1 transcriptional activation, curcumin attenuates the expression of pro-inflammatory cytokines while leaving the physiological baseline of cellular metabolism intact. In cartilage, it actively represses the matrix-degrading enzymes MMP-1, MMP-3, MMP-13, and ADAMTS5, maintains water-binding proteoglycan content, and protects chondrocytes from inflammatory apoptosis. In damaged tendons, curcumin stimulates tenogenic differentiation of local stem cells via PI3K/Akt signaling, supports the proper maturation of dense Type I collagen fibers, and prevents restrictive peritendinous scar adhesions, preserving both joint mobility and mechanical breaking strength.   

From a translational perspective, these findings indicate that clinical protocols should reconsider relying on continuous NSAIDs as the default intervention for connective tissue injuries, post-surgical recovery, and chronic degenerative conditions. Where synthetic NSAIDs are deemed necessary, their use should be confined to short-term acute flare-ups to avoid interrupting early tissue remodeling. For long-term joint preservation, ongoing tendinopathy rehabilitation, and chronic osteoarthritis management, optimized bio-enhanced curcumin formulations deliver pain relief and functional restoration comparable to conventional pharmaceuticals, all while preserving the biological processes required for lasting musculoskeletal repair.   

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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6653)

Date: September 10, 2026 10:57 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The Ultimate Guide to Cellular Longevity: NAD+, Methylation, and Senolytics

Introduction: Understanding Cellular Aging and Energy Decline

Cellular aging is characterized by interconnected biological disruptions known as the hallmarks of aging. These encompass genomic instability, epigenetic alterations, mitochondrial decay, loss of proteostasis, and cellular senescence. Rather than operating as isolated occurrences, these phenomena establish a self-reinforcing degenerative cycle: declining cellular power generation impairs enzymatic genetic repair, promoting the accumulation of damaged cells that enter irreversible growth arrest and poison surrounding healthy tissues. Mitigating cellular aging requires examining how microscopic bioenergetic pathways deteriorate and evaluating how targeted nutritional and biochemical interventions can restore cellular homeostasis.

The Role of Mitochondria and ATP Production

A youthful cell functions like an efficient municipal power grid, dynamically matching energetic demands with immediate ATP output. However, as biological aging progresses, mitochondrial efficiency declines. The electron transport chain becomes structurally leaky, inadvertently shedding electrons that react with ambient molecular oxygen to produce reactive oxygen species (ROS). While regulated levels of ROS participate in vital intracellular signaling, chronic excess induces widespread oxidative stress.

Mitochondria are exceptionally vulnerable to this oxidative burden because they carry their own circular genetic material, known as mitochondrial DNA (mtDNA). Unlike nuclear DNA, mtDNA lacks the protective shielding of histone proteins and possesses rudimentary repair systems. As a result, mtDNA sustains cumulative oxidative damage, encoding increasingly defective electron transport chain proteins. This dynamic generates a bioenergetic deficit: degraded mitochondria synthesize progressively less ATP while emitting greater volumes of damaging free radicals. Deprived of optimal ATP reserves, cells lack the energy necessary to drive vital enzymatic repair cascades, accelerating structural degeneration and functional exhaustion.

How Cellular Senescence Accelerates the Aging Process

Senescent cells, colloquially known as "zombie cells," enter a state of permanent growth arrest while actively resisting programmed cell death (apoptosis). Over time, these cells accumulate within adipose depots, skeletal muscle, the vascular endothelium, and major organs, largely because immune surveillance and clearance pathways simultaneously lose functional efficiency.

The systemic danger of senescent cells stems from their secretome. Rather than remaining biologically inert, senescent cells develop a hyperactive secretory state termed the Senescence-Associated Secretory Phenotype (SASP). The SASP is a destructive mixture of pro-inflammatory cytokines, chemokines, extracellular matrix-degrading matrix metalloproteinases (MMPs), and reactive oxygen species.

Through this toxic secretome, even a small burden of senescent cells can impair whole-tissue architecture. SASP factors degrade surrounding structural proteins, induce insulin resistance in neighboring metabolic cells, and biochemically force adjacent healthy cells into secondary senescence. This persistent paracrine signaling fuels chronic, sterile, low-grade systemic inflammation, termed "inflammaging," which accelerates systemic tissue degeneration and elevates susceptibility to degenerative age-related pathologies.

Nicotinamide Riboside (NR) and the NAD+ Salvage Pathway

The Biochemistry of NAD+ Depletion Over Time

The primary enzymatic driver of age-related NAD+ destruction is CD38, a membrane-bound glycohydrolase expressed on immune cells that is upregulated in response to chronic SASP exposure. Concurrently, lifelong genotoxic damage causes persistent activation of Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that cleaves the glycosidic bonds of NAD+ to assemble branched poly(ADP-ribose) chains at DNA lesion sites. Because PARP-1 consumes NAD+ without directly recycling the molecule, chronic DNA damage depletes intracellular NAD+ pools, impairing bioenergetics and limiting sirtuin activity.

How NR Efficiently Boosts Cellular NAD+ Levels

The salvage pathway recycles the breakdown product nicotinamide (NAM), which is released whenever NAD+-consuming enzymes execute their functions. Under normal conditions, cells convert free nicotinamide into nicotinamide mononucleotide (NMN) via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), after which NMN adenylyltransferases (NMNAT1–3) complete the conversion into NAD+. However, NAMPT expression declines with advancing age, chronic inflammation, and metabolic stress, limiting the recycling capacity of the cell.

Nicotinamide Riboside (NR) is a naturally occurring pyridine nucleoside that bypasses this enzymatic bottleneck. Upon cellular entry via equilibrative nucleoside transporters, NR is directly phosphorylated into NMN by nicotinamide riboside kinases (NRK1 and NRK2) using a single molecule of ATP. Because the NRK pathway remains intact and robust across the lifespan, NR provides an efficient alternative entry point into the NAD+ salvage cascade.

Clinical evaluations in humans confirm the safety, bioavailability, and pharmacokinetics of oral NR supplementation. Randomized, double-blind, placebo-controlled trials reveal that oral NR chloride produces dose-dependent increases in steady-state whole blood NAD+ concentrations. Dosing regimens of 100 mg, 300 mg, and 1,000 mg daily elevate blood NAD+ levels by approximately 22%, 51%, and up to 142%, respectively, within two weeks of administration, maintaining these elevations throughout continuous use. High-resolution metabolomic analyses also demonstrate parallel elevations in nicotinic acid adenine dinucleotide (NAAD), establishing it as a reliable biomarker of active intracellular NAD+ synthesis without hepatic or systemic toxicity.

Sirtuin Activation and DNA Repair Mechanisms

In the nucleus, SIRT1 coordinates defense against cellular decline. When activated by restored NAD+ levels, SIRT1 deacetylates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a), the master transcriptional coactivator of mitochondrial biogenesis. This deacetylation stimulates mitochondrial replication and assembly, expanding functional respiratory capacity. Concurrently, SIRT1 deacetylates the p65 subunit of nuclear factor-kappa B (NF-kB), suppressing the transcription of pro-inflammatory cytokines. In the mitochondria, SIRT3 utilizes NAD+ to deacetylate metabolic enzymes and superoxide dismutase 2 (SOD2), enhancing the organelle's capacity to neutralize reactive oxygen species.

At the same time, cellular NAD+ levels directly regulate genomic integrity through PARP-1. When genotoxic stress or oxidative damage induces single- or double-strand DNA breaks, PARP-1 binds to the damaged termini using its zinc-finger domains. Bound PARP-1 hydrolyzes NAD+ to synthesize extensive, negatively charged poly(ADP-ribose) polymers on itself and adjacent histones. This modification relaxes chromatin architecture and establishes an electrostatic scaffold that recruits base excision repair and homologous recombination complexes.

Recent discoveries demonstrate close crosstalk between sirtuins and PARP-1 during DNA repair. PARP-1 recruits SIRT1 to double-strand breaks, where SIRT1 deacetylates the chromatin-remodeling ATPase BRG1 to displace nucleosomes and facilitate homologous recombination. However, because PARP-1 and SIRT1 draw from the same intracellular NAD+ pool, severe NAD+ depletion forces a biological compromise: PARP-1 consumes the scarce remaining cofactor to address DNA damage, leaving sirtuins deactivated. Restoring NAD+ via NR prevents this deficit, enabling concurrent genomic repair and sirtuin-mediated metabolic defense.

Quercetin: A Powerful Senolytic and mTOR Regulator

Clearing Senescent "Zombie" Cells from Tissues

Quercetin is a polyphenolic flavonoid found in capers, red onions, apples, and the flower buds of Sophora japonica. Beyond its classical antioxidant properties, quercetin functions as a senolytic compound that exerts multi-target inhibitory effects across the SCAP network. By inhibiting the upstream PI3K/Akt survival axis and downregulating anti-apoptotic defenses, quercetin disrupts the signaling that protects senescent cells from intrinsic apoptosis. Deprived of these survival signals, senescent cells undergo programmed cell death.

Preclinical studies demonstrate that senolytic protocols utilizing quercetin - often combined with the tyrosine kinase inhibitor dasatinib - reduce senescent cell burden across multiple tissues. This targeted clearance lowers circulating SASP factors, attenuates tissue fibrosis, restores endothelial reactivity, and improves functional health span. By removing senescent cells, quercetin mitigates the primary driver of chronic, low-grade inflammaging.

Modulating the mTOR Pathway for Optimal Autophagy

Autophagy is an intracellular degradation system that packages damaged organelles, misfolded protein aggregates, and biological debris into double-membraned autophagosomes for lysosomal degradation and recycling. A specialized branch of this pathway, mitophagy, selectively targets and clears damaged mitochondria. In modern metabolic conditions characterized by continuous caloric intake, mTORC1 can remain persistently active. This persistent signaling suppresses autophagy, causing damaged organelles and toxic aggregates to accumulate within tissues.

Quercetin functions as a natural modulator of mTOR signaling. By inhibiting upstream PI3K/Akt signaling and activating intracellular energy sensors, quercetin attenuates overactive mTORC1, mimicking the metabolic effects of caloric restriction. This down-regulation relieves inhibition on the ULK1 autophagy initiation complex, stimulating both general autophagy and mitophagy. As autophagy proceeds, cells clear protein aggregates and eliminate damaged mitochondria, supporting cellular longevity and proteostasis.

Enhancing Absorption: Phytosomes and Dietary Fats

To address these pharmacokinetic limitations, advanced delivery systems such as phytosomes were engineered. A phytosome is a 100% food-grade molecular complex where individual polyphenolic molecules are bound to dietary phospholipids, typically sunflower-derived phosphatidylcholine. Unlike a classical liposome - which encapsulates water-soluble compounds inside an aqueous core enclosed by a lipid bilayer - a phytosome forms an amphiphilic complex at the molecular level.

The polar head of the phosphatidylcholine molecule forms hydrogen bonds with the hydroxyl groups of the quercetin molecule, while its lipophilic fatty acid tails extend outward. This structural arrangement shields the polar regions of the flavonoid, creating a lipid-compatible complex that integrates smoothly into the intestinal mucosa.

The Importance of Methylation in Healthy Aging

Vitamin B-Complex and Choline as Essential Methyl Donors

At the center of this pathway sits S-adenosylmethionine (SAM), the universal methyl donor in human biology. When a methyltransferase enzyme transfers a methyl group from SAM to an acceptor molecule, SAM is converted into S-adenosylhomocysteine (SAH). SAH functions as a potent competitive inhibitor of intracellular methyltransferases. To maintain functional methylation, SAH is rapidly hydrolyzed into homocysteine, a sulfur-containing amino acid that must be remethylated or cleared through transsulfuration.

Homocysteine clearance proceeds through two distinct remethylation pathways. The primary route operates across most tissues via the enzyme methionine synthase, which requires vitamin B12 in its active methylcobalamin form. Methionine synthase transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF, the active form of folate) to homocysteine, regenerating methionine. The ongoing production of 5-MTHF depends on the enzyme methylenetetrahydrofolate reductase (MTHFR), which utilizes riboflavin (vitamin B2) as a cofactor.

Alternatively, excess homocysteine can be routed into the transsulfuration pathway by vitamin B6 (as pyridoxal-5'-phosphate) to synthesize cystathionine, cysteine, and ultimately the antioxidant glutathione.

A secondary remethylation pathway, active predominantly in hepatic and renal tissues, bypasses folate entirely. In this route, dietary choline is oxidized to betaine (trimethylglycine or TMG). The enzyme betaine-homocysteine S-methyltransferase (BHMT) then transfers a methyl group from betaine directly to homocysteine, yielding methionine and dimethylglycine.

When dietary intake of active B-vitamins or choline is insufficient, or when genetic variations like MTHFR polymorphisms reduce pathway flux, the methylation cycle slows. Homocysteine accumulates in circulation, promoting vascular and neurological inflammation, while SAM reserves decline, restricting cellular methylation capacity.

Understanding DNA Methylation and Epigenetic Health

Under physiological conditions, DNA methylation maintains genomic stability and coordinates transcription. Methylation of promoter regions condenses chromatin, repressing transposable elements and silencing genes inappropriate for a given cell type. Conversely, hypomethylated promoters maintain an open chromatin state, allowing transcription factors to bind and initiate gene expression.

During biological aging, this epigenetic landscape undergoes progressive dysregulation, a phenomenon termed "epigenetic drift". Aging cells experience global hypomethylation alongside focal hypermethylation of specific gene promoters. Global loss of methyl tags destabilizes the genome, activating retrotransposons and pro-inflammatory pathways. Simultaneously, hypermethylation at targeted promoter sites silences critical tumor suppressor genes and DNA repair complexes.

This systematic change in DNA methylation patterns is consistent across populations, allowing researchers to develop molecular "epigenetic clocks". Algorithms such as the Horvath clock, PhenoAge, and GrimAge quantify biological age by profiling the methylation status of specific CpG sites across the genome. These clocks assess whether individuals are aging faster or slower than their chronological years. Ensuring a steady supply of methyl donors and preventing unnecessary SAM depletion supports DNMT activity, maintaining epigenetic patterns and genomic stability.

How the Methylation Cycle Impacts Energy and Cognitive Focus

A major consumer of methyl reserves is the endogenous synthesis of creatine. Approximately 40% of all SAM-derived methyl groups in the human body are utilized by guanidinoacetate N-methyltransferase (GAMT) in the liver to synthesize creatine. Creatine then translocates to the brain and skeletal muscle, where it is phosphorylated into phosphocreatine.

Phosphocreatine functions as a rapid energy buffer, donating a high-energy phosphate group to regenerate ADP into ATP in milliseconds during demanding physical or cognitive tasks. When methyl donor availability falls, endogenous creatine synthesis drops, depleting phosphocreatine reserves and increasing susceptibility to neuromuscular and cognitive fatigue.

Methylation is equally central to central nervous system architecture. SAM provides methyl groups to convert phosphatidylethanolamine into phosphatidylcholine, the predominant phospholipid comprising neuronal cell membranes and the myelin sheaths that insulate axons. Intact myelin preserves rapid action potential conduction throughout the nervous system.

Furthermore, free choline derived from this pathway is the direct precursor to acetylcholine, the neurotransmitter required for attention, working memory, and learning.

The methylation cycle also governs monoamine neurotransmitter metabolism. SAM is required for the synthesis of adrenaline (epinephrine) from noradrenaline, while catechol-O-methyltransferase (COMT) relies on SAM to degrade dopamine and norepinephrine within the prefrontal cortex. Sluggish methylation disrupts this balance, contributing to cognitive fatigue, mood variability, and impaired mental performance.

Building a Comprehensive Longevity Protocol

Synergizing NR, Quercetin, and Methylated B-Vitamins

This synergy is grounded in the direct biochemical intersection between the NAD+ salvage pathway and the methylation cycle. When high-dose NR is supplemented to boost systemic NAD+, sirtuins and PARP enzymes consume the newly synthesized cofactor, generating substantial quantities of free nicotinamide (NAM). This intracellular nicotinamide faces two primary metabolic fates: it can be recycled back into NAD+ through the NAMPT-dependent salvage loop, or it can be cleared via methylation.

When the influx of nicotinamide exceeds salvage recycling capacity, the excess is cleared to avoid feedback inhibition of sirtuin enzymes. To accomplish this, the enzyme nicotinamide N-methyltransferase (NNMT) transfers a methyl group from SAM directly onto nicotinamide, forming 1-methylnicotinamide (1-MNA/MNAM), which is subsequently excreted in urine.

Prolonged, high-dose precursor administration without nutritional methyl support can elevate NNMT flux, depleting intracellular SAM reserves. As methyl groups are consumed clearing nicotinamide, the cellular SAM-to-SAH ratio falls, which can elevate circulating homocysteine and reduce methyl availability for DNA methylation and neurotransmitter synthesis.

Co-administering a fully methylated B-complex alongside choline or betaine addresses this potential bottleneck. Providing active methyl donors (such as 5-MTHF, methylcobalamin, and betaine) maintains the one-carbon donor pool. Even during increased NNMT activity, SAM pools remain stable, protecting DNA methylation fidelity and maintaining homocysteine within safe parameters.

Quercetin reinforces this protocol through complementary mechanisms. By clearing senescent cells and reducing SASP-mediated inflammation, quercetin downregulates CD38, the primary enzyme responsible for age-related NAD+ degradation. Suppressing CD38 prevents unnecessary breakdown of newly synthesized NAD+, enhancing the efficiency of NR supplementation.

Furthermore, while NR provides the NAD+ necessary to activate SIRT1-driven mitochondrial biogenesis, quercetin concurrently modulates mTORC1 to stimulate autophagy. This coordinated action ensures that newly generated mitochondria operate in an environment cleared of proteotoxic cellular debris.

The Crucial Role of Magnesium Glycinate and Zinc in Cellular Function

Magnesium serves as an obligatory cofactor in over 300 enzymatic reactions, primarily through its interaction with ATP. In biological systems, ATP exists predominantly as a chelate with a divalent magnesium ion, forming biologically active Mg2+ -ATP.

Every enzymatic reaction that synthesizes, transfers, or consumes cellular energy - including the enzymes of the NAD+ salvage pathway (NRK and NMNAT) and DNA polymerases - strictly requires Mg2+ -ATP as its substrate. Magnesium deficiency impairs these phosphorylation reactions, reducing the cellular utilization of NAD+ precursors.

Additionally, magnesium is an essential cofactor for the enzymes that activate dietary B-vitamins into their active forms. Supplying magnesium as magnesium glycinate provides high gastrointestinal bioavailability, minimal laxative effect, and yields glycine to support inhibitory neurotransmission and restful sleep.

Zinc serves as a vital structural component for more than 3,000 human transcription factors and enzymatic proteins. Its most prominent structural role in longevity occurs within zinc-finger motifs. These are specialized protein conformations stabilized by a zinc ion coordinated to cysteine and histidine residues.

The DNA damage sensor PARP-1 utilizes three zinc-finger domains to identify, track, and physically bind to single- and double-strand DNA breaks. Without adequate intracellular zinc, PARP-1 cannot properly assemble or dock onto damaged chromosomes, impairing DNA repair and increasing genomic instability.

Zinc is also an obligatory structural component of copper/zinc superoxide dismutase (Cu/Zn-SOD or SOD1), the primary cytosolic antioxidant enzyme that dismutates superoxide radicals into hydrogen peroxide, protecting mitochondrial membranes and nuclear DNA from premature senescence.

Integrating Prebiotics (like Acacia and Inulin) for Gut-Derived Longevity Markers

The gut epithelium consists of a single-cell monolayer sealed by tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and claudins. When this physical barrier is disrupted by poor dietary fiber intake or dysbiosis, gut permeability increases.

This allows lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, to enter the portal and systemic circulation. The resulting "metabolic endotoxemia" activates Toll-like receptor 4 (TLR4) on immune cells, inducing NF-kB and systemic pro-inflammatory cytokine production. This persistent gut-derived inflammation exacerbates the SASP, accelerates tissue senescence, upregulates CD38, and drains systemic NAD+ reserves.

These short-chain fatty acids, particularly butyrate, exert direct protective effects on systemic longevity. Butyrate provides the primary metabolic fuel for colonic epithelial cells, supplying more than 70% of their baseline energy needs and supporting mitochondrial function within colonocytes.

Furthermore, SCFAs upregulate the expression of epithelial tight junction proteins (ZO-1, occludin, and claudin-1), restoring intestinal barrier integrity and preventing the translocation of inflammatory LPS into systemic circulation.

Systemically absorbed butyrate also functions as an endogenous histone deacetylase (HDAC) inhibitor, suppressing pro-inflammatory gene expression and supporting regulatory T cell (T_reg) development. Reducing metabolic endotoxemia dampens systemic inflammation, protecting vascular function and preventing premature NAD+ depletion.

Conclusion: The Integrated Cellular Longevity Matrix

Quercetin Phytosome clears senescent cells and modulates mTORC1, stimulating autophagy while dampening the inflammatory SASP cascade that accelerates CD38-mediated NAD+ destruction.

Methylated B-vitamins, active folate, and choline replenish SAM reserves, balancing the methyl requirements of NNMT-mediated nicotinamide clearance, preserving epigenetic DNA methylation, and maintaining neurotransmitter production.

Magnesium glycinate and zinc provide the structural and catalytic foundation required for ATP utilization, B-vitamin activation, and PARP-1 zinc-finger DNA repair docking.

Finally, prebiotic fibers generate short-chain fatty acids like butyrate, reinforcing the intestinal barrier and preventing metabolic endotoxemia from fueling systemic inflammation.

By coordinating energy replenishment, cellular waste clearance, epigenetic maintenance, and the suppression of systemic inflammation, this unified approach directly addresses the underlying drivers of cellular aging to support long-term physiological vitality.

--
Content Put together by Darrell Miller CEO of VitaNet LLC

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6650)

Date: May 22, 2026 04:29 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Is there anything else DLPA can do be sides Pain management and Mood?

Is there anything else DLPA can do be sides Pain management and Mood?

Here is what else DLPA can do:

1. Appetite Regulation and Satiety

2. Thyroid Hormone Synthesis

3. Melanin Production (Skin Pigmentation)

4. Attention and Executive Function

5. Addiction Recovery Support

When diving deeper into the physiological applications of DLPA, there are several advanced, highly specific mechanisms that make it particularly interesting, especially regarding athletic performance, metabolic pathways, and cellular recovery.

Here are a few of the more complex, nuanced roles of DLPA in the body:

6. Combating Central Nervous System (CNS) Fatigue

By supplementing with L-phenylalanine, the brain has a steady supply of precursor material to maintain dopamine synthesis. This helps delay the onset of CNS fatigue, allowing for sustained mental drive, higher intensity, and better neurological output throughout a grueling session.

7. Pain Management Without Blunting Hypertrophy

Because the D-phenylalanine in DLPA does not interfere with inflammation or COX enzymes—working entirely by shielding circulating endorphins—it provides musculoskeletal comfort without compromising the cellular signaling required for muscle repair and growth. It allows the body's natural inflammatory repair mechanisms to run their course uninterrupted.

8. The Methylation Cycle Bottleneck

The enzyme responsible for this final step (PNMT) relies entirely on S-adenosylmethionine (SAMe) to donate a methyl group. If the methylation cycle is sluggish or deficient in necessary cofactors (like methylated B-vitamins), the catecholamine cascade bottlenecks at norepinephrine. Therefore, DLPA's ability to fully support the adrenal axis is directly dependent on the efficiency of the body's methylation pathways.

9. Prolonging the "Lifter's High"

Would you like to explore how to position this mTOR-safe, CNS-supporting angle into a specific educational breakdown for a retail or blog audience?

Summary:

Beyond its foundational role in chronic pain relief, DLPA serves as a versatile precursor that supports several advanced metabolic, cognitive, and physical functions. Because the L-phenylalanine half converts into tyrosine, it provides the essential raw materials required for thyroid hormone synthesis (T3 and T4), melanin skin pigmentation production, and the release of cholecystokinin (CCK), a gut peptide that signals satiety and regulates appetite. Furthermore, by elevating dopamine and norepinephrine, DLPA enhances executive function, working memory, and focus, making it a valuable asset in nootropic protocols and a supportive tool for rebuilding depleted neurotransmitter stores during substance recovery.

In the context of high-intensity athletic performance, DLPA offers unique physiological advantages for training and recovery. It directly combats central nervous system (CNS) fatigue by replenishing the dopamine depleted during heavy resistance training, thereby maintaining neural drive without interrupting muscle protein synthesis. Unlike traditional NSAIDs, which blunt the acute inflammatory response and stall the mTOR pathway, DLPA provides musculoskeletal comfort solely by shielding endogenous opioids (endorphins and enkephalins) from enzymatic breakdown. This allows the natural muscle-repair mechanisms to run their course uninterrupted while simultaneously prolonging the post-exercise "lifter's high." However, its full efficacy remains dependent on a healthy methylation cycle, as the final conversion of norepinephrine to adrenaline requires adequate methyl donors like SAMe.

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Date: November 20, 2025 12:16 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: "The Butyrate Paradox" Does Butyrate Trigger Apoptosis in Just Colon Cancer or All Cancers Throughout The Body?

The Butyrate Paradox primarily refers to the differential effect of butyrate on normal versus cancerous cells in the colon.

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Date: July 16, 2025 11:08 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Borage Seed Oil: A Rich Source of GLA with Diverse Health Benefits

Borage Seed Oil: A Rich Source of GLA with Diverse Health Benefits

The Power of GLA: An Anti-Inflammatory Agent

Soothing Skin Ailments

• Eczema (Atopic Dermatitis): Studies suggest that the GLA in borage seed oil can help reduce the inflammation, itching, and redness associated with eczema. It is believed that individuals with eczema may have a defect in the enzyme that converts linoleic acid to GLA, leading to a deficiency that borage seed oil can help correct.
• Acne and Rosacea: By modulating inflammation, borage seed oil may also help to calm the redness and irritation associated with acne and rosacea.

Relief for Rheumatoid Arthritis

Hormonal Harmony and PMS Relief

Important Considerations and Potential Side Effects

Potential side effects of borage seed oil are typically mild and may include digestive issues such as bloating, gas, or indigestion. As with any supplement, it is advisable to consult with a healthcare professional before starting to take borage seed oil, especially for those who are pregnant, breastfeeding, or taking other medications, particularly blood thinners or anti-seizure drugs.

In conclusion,

Borage seed oil, rich in GLA, is a valuable natural supplement with many potential health benefits. Its ability to modulate cellular inflammation makes it a compelling option for supporting skin, managing arthritis, and easing hormonal discomfort.

Here are even more concise versions:

• Rich in GLA, borage seed oil is a powerful natural supplement that can reduce inflammation, improve skin health, and ease symptoms of arthritis and hormonal imbalances.
• Borage seed oil's high GLA content makes it a valuable supplement for reducing inflammation, supporting skin health, and managing arthritic and hormonal issues.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6621)

Date: May 31, 2024 11:05 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The History of Stevia: From Ancient Sweet Leaf to Global Sweetener

The History of Stevia: From Ancient Sweet Leaf to Global Sweetener

Stevia, a natural sweetener that has become globally popular in recent years, boasts a rich history spanning centuries. This article delves into the origins and historical significance of stevia, shedding light on its traditional use by indigenous peoples and its evolution into a mainstream alternative to sugar.

The Origins of Stevia

Stevia, scientifically known as Stevia rebaudiana, originates from South America. This small, green plant is part of the Asteraceae family, which also includes daisies and sunflowers. The leaves of the stevia plant contain sweet compounds known as steviol glycosides, which are responsible for its sweetness.

Traditional Use by the Guaraní People

The historical journey of stevia begins with the Guaraní people of Paraguay and Brazil, who have used the plant for over 1,500 years. The Guaraní referred to stevia as "ka'a he'ê," which translates to "sweet herb." They traditionally used stevia leaves to sweeten beverages like yerba maté, a popular herbal tea, and to enhance the flavor of various traditional dishes.

Stevia wasn't just a sweetener for the Guaraní; it also held medicinal importance. The leaves were used to treat a variety of conditions, including burns, stomach issues, and as a general tonic. This dual use of stevia as both a sweetener and a medicinal plant highlights its invaluable role in indigenous culture.

Stevia's Journey to the Modern World

Rediscovery by European Explorers

The modern history of stevia began in the 16th century when European explorers first arrived in South America. Spanish botanist and physician Pedro Jaime Esteve (1500–1556) is often credited with the early European studies on stevia, although the plant was not widely documented until later.

Interest in stevia grew in the early 20th century when it was scientifically studied by Paraguayan chemist Ovidio Rebaudi. Rebaudi analyzed the sweet properties of stevia leaves and confirmed that they were much sweeter than sugar, which caught the attention of the scientific community.

Introduction to Asia and Beyond

In the 1970s, stevia began gaining traction in Japan as the country sought alternatives to artificial sweeteners. Japanese researchers developed methods for extracting and refining steviol glycosides from stevia leaves, making it possible to use stevia as a commercial sweetener. The success of stevia in Japan set the stage for its global acceptance.

Stevia in the Modern Health Movement

Health Benefits and Advantages

Stevia's rise in popularity can be attributed to its myriad of health benefits. Unlike sugar, stevia is calorie-free, making it an attractive option for those managing their weight. Additionally, stevia has a negligible effect on blood glucose levels, which is beneficial for individuals with diabetes or those monitoring their carbohydrate intake.

Moreover, steviol glycosides are stable at high temperatures, making stevia a versatile sweetener suitable for cooking and baking. This thermal stability, combined with its natural origin, has positioned stevia as a preferred option for health-conscious consumers.

Regulatory Approval and Global Adoption

The journey of stevia to becoming a global sweetener has involved rigorous scientific scrutiny and regulatory approval. In 2008, the United States Food and Drug Administration (FDA) granted stevia the status of "Generally Recognized As Safe" (GRAS), which paved the way for its use in a wide range of food and beverage products.

Following the FDA's approval, other countries, including those in the European Union, Canada, and Australia, also approved the use of stevia in food and beverages. Today, stevia is found in everything from soft drinks to baked goods, reflecting its widespread acceptance and global reach.

Challenges and Future prospects

Overcoming Obstacles

Despite its many advantages, the path to widespread adoption of stevia has not been without challenges. One of the initial hurdles was the aftertaste associated with some of the early stevia extracts. However, advances in extraction and formulation techniques have significantly improved the taste profile of stevia, making it more palatable for consumers.

Another challenge has been ensuring the sustainable cultivation of stevia. As demand grows, it is essential to implement agricultural practices that support environmental sustainability and fair labor conditions for farmers.

Research and Innovation

The future of stevia holds exciting possibilities as ongoing research continues to explore new applications and improvements. Scientists are currently investigating the potential of stevia extracts in providing health benefits beyond sweetness, such as their antioxidant properties and possible roles in managing certain health conditions.

Innovations in biotechnology are also paving the way for the development of new stevia varieties with enhanced sweetness and improved agronomic traits. These advancements could further solidify stevia's position as a key player in the global sweetener market.

In Summary

The history of stevia is a fascinating journey from the rainforests of South America to the shelves of supermarkets around the world. From its traditional use by the Guaraní people to its rediscovery by European explorers and subsequent global adoption, stevia has proven to be a remarkable sweetener with enduring significance. As the modern world continues to prioritize health and wellness, stevia's natural sweetness offers a much-needed alternative to sugar, promising a future where we can enjoy the sweetness of life without compromising our health.

Are You Ready to Make a Sweet Change?

If you've been searching for a healthier way to satisfy your sweet tooth, the journey of stevia offers a compelling reason to make the switch. With its rich history rooted in traditional use by the Guaraní people, and its scientifically-backed benefits recognized globally, stevia stands out as a truly remarkable sweetener. Free from calories and gentle on blood glucose levels, it's an excellent choice for both weight management and diabetes care. Plus, its versatility in cooking and baking means you won't have to compromise on your favorite recipes.

Join the growing number of health-conscious consumers who are choosing stevia for a naturally sweet life. Explore its various forms—from whole leaves to refined steviol glycosides—and incorporate this natural sweetener into your diet today. Embrace the future of sweetening and enjoy the benefits of stevia for yourself and your loved ones.

Frequently Asked Questions (FAQ) About Stevia

What is stevia?

Stevia is a natural sweetener derived from the leaves of the Stevia rebaudiana plant, which is native to South America. It has been used for centuries by the Guaraní people and is known for being much sweeter than sugar while containing zero calories.

How is stevia used as a sweetener?

Stevia can be used in various forms, including whole leaves, powdered extracts, and liquid concentrates. It is commonly used to sweeten beverages, baked goods, and other foods. Thanks to its stability at high temperatures, stevia can also be used in cooking and baking.

Is stevia safe to consume?

Yes, stevia is considered safe for consumption. The United States Food and Drug Administration (FDA) has granted stevia the status of "Generally Recognized As Safe" (GRAS). It has also been approved for use in many other countries, including those in the European Union, Canada, and Australia.

Can stevia help with weight management?

Stevia can be an effective tool for weight management because it contains no calories. Replacing sugar with stevia in your diet can help reduce overall calorie intake, which may contribute to weight loss or maintenance.

Is stevia suitable for people with diabetes?

Stevia is suitable for people with diabetes as it has a negligible effect on blood glucose levels. This makes it a preferable alternative to sugar for those needing to monitor their carbohydrate intake. However, it is always best to consult with a healthcare provider before making any significant changes to your diet.

Does stevia have any side effects?

Stevia is generally well-tolerated and considered safe for most people. However, some individuals may experience mild side effects, such as digestive discomfort, when consuming large amounts. It is advisable to use stevia in moderation.

What does stevia taste like?

Stevia is known to be much sweeter than sugar, and its taste can vary depending on the form used and the specific product. Early versions of stevia extracts were noted for having a slight aftertaste, though modern formulations have significantly improved the taste profile.

How is stevia cultivated?

Stevia is typically grown in subtropical and tropical climates. Sustainable cultivation practices are essential as the demand for stevia increases. These practices include using environmentally friendly agricultural methods and ensuring fair labor conditions for farmers.

Are there any environmental benefits to using stevia?

Stevia has the potential to be more sustainable than traditional sugar crops. It requires less land and water to produce the same level of sweetness, which can reduce the environmental impact associated with sugar cultivation.

Can stevia be used in baking?

Yes, stevia can be used in baking due to its high-temperature stability. However, because it is much sweeter than sugar, recipes may need to be adjusted to account for its intensity. Many commercially available stevia sweeteners come with specific usage guidelines for cooking and baking.

Are there different types of stevia products?

Yes, stevia products come in various forms, including whole leaves, powdered extracts, and liquid concentrates. Some products are blended with other sweeteners or filler ingredients to better mimic the taste and texture of sugar.

How does stevia compare to artificial sweeteners?

Stevia is a natural sweetener, which sets it apart from many artificial sweeteners. It is derived from a plant and does not undergo extensive chemical processing. Many consumers prefer stevia because it is perceived as a more natural and healthier option.

What research is being done on stevia?

Ongoing research on stevia explores its potential health benefits beyond sweetness, such as its antioxidant properties and possible roles in managing certain health conditions. Innovations in biotechnology are also working to develop new stevia varieties with enhanced sweetness and other desirable traits.

Where can I buy stevia?

Stevia products are widely available at VitaNet LLC. Stevia can be found in the baking aisle or the section dedicated to natural and alternative sweeteners.

By understanding the benefits and uses of stevia, you can make an informed decision about incorporating this natural sweetener into your diet. With its rich history, proven health benefits, and versatility, stevia offers a compelling alternative to traditional sugar.

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Date: December 07, 2023 12:12 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?

Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?

Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body.

While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption.

GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age.

The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels.

In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body.

This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form.

But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them.

So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing!

Liver Health

When it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ.

Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds.

During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances?

But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker!

The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning.

So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being!

Alcohol Intoxication

Alcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells.

To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes.

The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group.

The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver.

Nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels.

Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy.

In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management.

Beautiful Skin

By activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions.

Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores.

Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects.

Skin Lightening

Skin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract.

The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women.

In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH.

Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin.

The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities.

In summary, the administration of glutathione, whether oral, buccal, or topical, has shown promising results in skin lightening and the improvement of complexion. Studies have demonstrated that glutathione not only enhances skin brightness but also reduces hyperpigmentation, wrinkles, and minimizes pores. Moreover, its effects have been evident in as little as two weeks, with a sustained impact over longer periods. These benefits were observed across a range of different skin types and ethnicities. However, it is important to highlight that these findings are based on specific populations, and more research needs to be conducted to confirm the consistency of these effects across a broader spectrum of skin types and ethnicities. The studies have also confirmed that the usage of glutathione is well-tolerated with no serious adverse effects reported.

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Date: May 11, 2022 12:19 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: How Melatonin Can Support a Healthy Sleep Cycle and More

Did you know that melatonin is a powerful free radical scavenger? This means that it helps protect the body from damage caused by harmful molecules called radicals. Melatonin is also naturally produced in the pineal gland and is present in high amounts in the GI tract. We will discuss some of the ways that melatonin supports health and wellness.

Melatonin and the body

Melatonin is a hormone that is produced by the pineal gland in the brain. It is responsible for regulating the body's internal clock, or circadian rhythm. The production of melatonin increases at night, and decreases during the day. This hormone is also available in supplement form, and is often used to treat jet lag or insomnia. When taken as a supplement, melatonin works by resetting the body's internal clock, making it easier to fall asleep and stay asleep. Additionally, melatonin may also help to reduce anxiety and improve mood. As a result, this hormone plays an important role in regulating the body's sleep-wake cycle.

How does melatonin support a healthy sleep cycle?

Melatonin is a hormone that help regulate the sleep cycle. The production of melatonin is stimulated by darkness and inhibited by light. As a result, melatonin levels typically start to rise in the evening as the sun sets, and they remain high throughout the night. In the morning, light exposure causes melatonin levels to drop, helping to wake us up and start the day. Melatonin supplements can be used to help people who have difficulty sleeping and staying asleep. This hormone helps to reset the body's natural sleep cycle, making it easier to fall asleep and stay asleep. As a result, melatonin can be an effective way to support a healthy sleep cycle.

What are some of the other benefits of melatonin?

It can help to boost the immune system, protect against cancer, and reduce inflammation. Research suggests that melatonin may also have neuroprotective effects and could be beneficial for people with Alzheimer's disease or Parkinson's disease.

Tips for getting a good night's sleep

Most people need about seven to eight hours of sleep a day. However, many people find it difficult to get enough rest. There are a number of things you can do to improve your sleep habits. First, create a regular sleep schedule and stick to it as much as possible. Go to bed and wake up at the same time each day, even on weekends. Second, create a relaxing bedtime routine. This might include taking a warm shower, reading a book, or writing in a journal. Third, create a comfortable sleep environment by making sure your bedroom is dark, quiet, and cool. Fourth, avoid caffeine and alcohol before bed. Caffeine can make it difficult to fall asleep and stay asleep, while alcohol can disrupt your sleep cycle. Finally, try not to use electronic devices in bed. The blue light emitted by screens can interfere with your body's natural sleep rhythm and take melatonin. By following these tips, you can improve your chances of getting a good night's sleep.

Scientific research

Research on melatonin began in the 1950s, and since then, numerous studies have been conducted on its potential health benefits. Some of the most promising research has found that melatonin may help to prevent cancer. In one study, melatonin supplements were found to reduce the risk of breast cancer recurrence by half. Other research has shown that melatonin may help to protect against colon cancer, prostate cancer, and ovarian cancer. Additionally, melatonin has been shown to boost the effectiveness of chemotherapy drugs and radiation therapy.

While more research is needed to confirm the exact role of melatonin in cancer prevention, the available evidence suggests that it could play a significant role in protecting against this disease. Therefore, it may be worth considering supplementing with melatonin if you are at high risk for cancer or are undergoing treatment for this disease.

References:

• How Melatonin Can Support a Healthy Sleep Cycle and More. (n.d.).
• Tips for Getting a Good Night's Sleep. (n.d.).
• The Role of Melatonin in Cancer Prevention. (n.d.).
• Cancer Treatment Centers of America. (2017, September 28). Melatonin Shows Promise as Cancer Treatment Adjuvant | Cancer Treatment Centers of America.
• National Sleep Foundation. (2015, July 29). Melatonin and Cancer Risk - National Sleep Foundation.
• Mayo Clinic Staff.(2018, March 23). Melatonin: Is it effective?Retrieved from Mayo Clinic: Diseases & Conditions.."Melatonin."

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Date: April 30, 2022 09:39 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Curcumin: The Superfood That Fights Inflammation

Do you suffer from inflammation? If so, you're not alone. Inflammation is a common problem that can cause pain and discomfort in the body. Fortunately, there is a natural remedy that can help: curcumin. Curcumin is a compound found in turmeric that has powerful anti-inflammatory properties. We will discuss the benefits of curcumin and how to add it to your diet.

What is inflammation and what causes it?

Inflammation is a natural process that helps the body heal. It occurs when the immune system responds to an injury or infection. The symptoms of inflammation include redness, swelling, and pain. While inflammation is a necessary part of the healing process, chronic inflammation can lead to serious health problems. Chronic inflammation is often caused by lifestyle factors, such as smoking, obesity, and stress. dietary factors can also contribute to chronic inflammation, including a diet high in sugar. Sugar causes the body to release inflammatory chemicals that can damage tissues and lead to disease. Therefore, reducing sugar intake can help to reduce the risk of chronic inflammation.

What are the symptoms of inflammation?

Inflammation is a natural process in the body that helps to protect us from injury and illness. It occurs when the immune system detects harmful stimuli, such as pathogens or damaged tissue, and triggers a series of reactions which boost the production of white blood cells. However, if inflammation becomes excessive or chronic, it can cause a range of physical symptoms, including redness and swelling at the site of inflammation, increased pain sensitivity, headache, fatigue and fever. Other common symptoms include irritation in the eyes and mouth, digestive issues like diarrhea and nausea, rashes or skin lesions, changes in appetite and mood swings. If you are experiencing any of these symptoms on a regular basis, it is important to take anti-inflammatory supplements to help control inflammation. One such supplement is curcumin.

How can curcumin help to reduce inflammation in the body?

Curcumin is a compound that can be found in turmeric, a bright yellow spice commonly used in cooking. This powerful phytochemical has been shown to have potent anti-inflammatory properties, and can help to reduce inflammation throughout the body. One of the main ways that curcumin achieves this effect is by blocking an enzyme known as cyclooxygenase, or COX. This enzyme is responsible for producing pro-inflammatory compounds called prostaglandins that are often associated with pain and swelling. By preventing their production, curcumin can help to control acute and chronic inflammation in the body, thereby reducing the risk of conditions such as arthritis, heart disease, and cancer. In addition to blocking COX activity, curcumin helps to reduce oxidative stress by inducing production of antioxidants like superoxide dismutase. Overall, these mechanisms make curcumin an excellent natural treatment for chronic inflammation and a host of related health problems.

How to add curcumin to your diet?

Adding curcumin to your diet is a great way to reap the many health benefits of this powerful natural compound. There are several different ways that you can incorporate more curcumin into your daily routine, from simply adding it to your favorite recipes to taking a supplement. For example, you can start off by incorporating turmeric into your cooking, as turmeric is one of the richest sources of curcumin in nature. Additionally, there are many curcumin supplements available on the market that can be easily incorporated into your daily routine. Ultimately, by making these simple changes in your diet, you can enjoy all the great benefits of curcumin for overall health and well-being.

The benefits of taking curcumin regularly

Curcumin is a compound found in the spice turmeric. It has powerful anti-inflammatory and antioxidant effects, and it has been used for centuries in traditional Chinese and Indian medicine. Recently, curcumin has begun to gain recognition in the Western world as well. A growing body of research suggests that curcumin may have a wide range of health benefits, including the ability to improve cognitive function, reduce inflammation, and even ward off cancer. Curcumin is generally well tolerated, but it can interact with certain medications. However, for many people, taking curcumin regularly can be a safe and effective way to improve overall health.

To fight inflammation, reduce sugar consumption and take curcumin

To help reduce inflammation in the body, it is important to reduce your sugar intake and take curcumin supplements. These steps are vital because chronic inflammation has been linked to a wide range of health conditions, such as heart disease, diabetes, and even cancer. Additionally, sugar consumption can also worsen inflammation by triggering the release of inflammatory chemicals like cytokines and free radicals.

One of the best ways to fight against inflammation is to take curcumin supplements on a regular basis. Curcumin is a natural anti-inflammatory agent found in turmeric, a spice that is commonly used in Indian cooking. Research has shown that curcumin can be just as effective as anti-inflammatory drugs in reducing levels of tumor necrosis factor alpha (TNF-alpha), a potent inflammatory chemical released by cells. Furthermore, studies have also shown that taking curcumin regularly may benefit overall health and prevent certain age-related diseases like Alzheimer's.

Overall, reducing your sugar intake and taking curcumin supplements are two effective ways to fight inflammation and improve overall health. By following these simple steps, you can help protect yourself from the many negative effects of chronic inflammation.

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Date: September 01, 2020 11:03 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Curcumin and Grapeseed

Smoking, Chemical exposure, pesticides, nutrient deficiencies, to much sun exposure, and over the counter drugs and prescriptions can cause cancer. In the news, there are forever chemical roundup found in our water supply, it is no wonder we are laden with cancer as a society.

Fortunately, a healthy cancer preventing diet along with natural plant compounds can be far more effective and cost a lot less than conventional care alone.

Two top suggested natural medicines available right now are curcumin and grape seed extract. These two herbs are an amazing pair, curcumin is a fat soluble herb to fight oxidation on the fatty oil side in the body and grape seed extract is water soluble, making it a great antioxidant to fight oxidative stress on the water side of a cell. Cells in the body are made up of oil(fats) and water. The impact of both together on your health is virtually miraculous.

Curcumin neutralizes unstable free radicals that take electrons from nearby molecules, and stop them from creating a cascade of damaged cells. It also reduces inflammation reduces inflammation markers in the body to prevent prevent tissue degradation.

Curcumin has been shown to stop the changes that happen from free radical damage causing normal cells to become cancerous, and tumorous formations, and can even stop cancer from metastasizing or migrating to other parts of the body. Published studies anticancer activity have found that it can suppress breast, prostate, liver, skin, colon and lung cancer cells.

Curcumin Must Be Absorbed To Be Useful

One of the challenges or using curcumin for cancer prevention and treatment is that not all curcumin extracts are easily absorbable into the body. Blending curcumin in Turmeric essential oil enhances absorption and provides the additional benefits of ar-turmerone, a compound in the oil.

Curcumin Makes Chemo More Effective

There is big potential for curcumin when used with conventional treatment. BCM-95 curcumin, through research, has shown to sensitize human colon cancer cells to chemotherapy treatment where it would otherwise be resistant to this form of treatment. In some cases tumor recurrence rates can be as high as 60% but when treated with curcumin while under conventional treatment, curcumin boosted the effectiveness of the chemo drug 5-fluorouracil against cancer stem cells.

Curcumin has great potential in conjunction with conventional cancer treatment and recovery. It has been found that as chemo treatment progresses, cancer cells become resistant to the chemo treatment and the dosage has to be increased as the treatment continues increasing the toxic side effects. Fortunately, curcumin taken in conjunction with conventional cancer treatment can improve the effectiveness of chemo and so the dosage can be lowered reducing the toxic side effects for individuals. This is good news!

Curcumin Protects The Body During Cancer Treatment

In a clinical study with curcumin, it showed to alleviate side effects of one of the most common treatments of prostate cancer known as external beam radiotherapy (EBRT) where the doctor uses radiation to destroy tumorous cancel cells. This sort of therapy has many side effects making it a difficult therapy for most men. I often causes sexual dysfunction, digestive problems, urinary tract pain and loss of control. The higher the radiation dosage the more effective the treatment is but this causes significant discomfort, that is why most doctors lean towards lower dosages which makes the treatment less effective.

The clinical study administered 3000mg of BCM-95 curcumin that is 1000mg x 3 per day or a placebo one week before therapy started and during the treatment length. Each capsule of curcumin contained curcuminoids, curcumin, demethoxycurcumin, bisdemethoxycurcumin, and essential oil of turmeric, this is a full spectrum curcumin supplement.

At the end of the treatment which lasted 20 weeks the most dramatic difference between the two groups in the study was urinary symptoms. The curcumin group said a 50% decrease in symptoms or side effects of the radiation. Also, researchers noted that the curcumin did not reduce the efficacy of the EBRT.

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Date: August 31, 2020 12:36 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Hintonia Latiflora Combined With Key Nutrients for Blood Sugar Control

Type 2 diabetes is increasing at an alarming rate. With certain life style changes, exercise, along with Sucontral D, one can reduce blood sugar.

Hintonia latiflora combined with key nutrients for blood sugar control can:

• Lower A1c levels by 10%
• Improve fasting and postprandial blood sugar by 23% and 24% respectively.
• Balance total cholesterol and reduce triglyceride levels
• Prevent hypoglycemia - undesirable drops in blood sugar
• Reduce or eliminate the need for medication in nearly half the patients

The CDC reports that 84 million Americans have pre diabetes which is higher than normal blood sugar levels but not yet considered type 2 diabetes. It is said there is an additional 30 million type 2 diabetes and roughly 24% do not know they have high blood sugar levels.

Hintonia has been clinically studied in Europe for decades, 60 years to be exact, clinically studied to help bot pre- and type 2 diabetes. By the end of these studies, participants in the studies experienced an average of 10.4% improvement in their A1C, and 23.3% improvement in their fasting glucose levels and 24.9% on their postprandial glucose levels. This is quite significant indeed.

In conclusion, the clinical studies proved Hintonia improved blood glucose levels. out of 114 patients 45 were able to reduce their medication and 10 were able to eliminate their medication all together.

Reference:Hintonia concentrate for the dietary treatment of increased blood sugar values: Results of a multicentric, prospective, non-interventional study with a defined dry concentrate of Hintonia latiflora. Schmidt M, Hladikova M Naturheilpraxis, Feb. 2014 (Translated).

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Date: May 21, 2019 04:43 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Study shows that vitamin D can help lower your risk of Type 2diabetes

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Date: May 09, 2019 09:51 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: For the men: Multivitamins can keep heart disease at bay

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Date: April 26, 2019 03:15 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Omega-3s found to benefit children diagnosed with behavioraldisorders

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Date: February 09, 2019 10:05 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Compounds in pomegranate juice found to trigger cancer cell death

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Date: January 16, 2019 08:50 AM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Camu camu fruits are rich in an anthocyanin that stops tumors fromgrowing

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Date: December 12, 2018 09:09 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 12 Benefits and Uses of Argan Oil

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Date: December 11, 2018 11:22 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Pumpkin Seeds: The Antioxidant Seeds that Combat Diabetes, HeartDisease & Cancer Cells

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Date: December 08, 2018 11:16 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Gotu Kola is one of the most useful plant remedies found inAyurvedic medicine

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Date: November 29, 2018 12:32 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 5 Ginger Benefits for Men That You Should Know About

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Date: October 29, 2018 01:51 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Curcumin Targets Cancer Cells

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Date: October 22, 2018 09:52 AM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Riboflavin Foods: Top 15 Vitamin B2 Foods & Their Benefits

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Date: April 12, 2018 05:17 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 5 undeniable ways to protect your prostate

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Date: January 06, 2018 03:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Antioxidant power: Blueberry extract found to improve health outcomes for women receiving radiation for cervical cancer, reducing the damaging effects of the therapy

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Date: November 15, 2017 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Vitamin K: Your New Superhero For a Healthy Living

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Date: October 06, 2017 10:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Annatto: Is This Natural Food Dye Safe?

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Date: September 16, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Look At What Happens To Your Body After Eating At Least One Nut A Day!!

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Date: August 30, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Cancer-fighting super foods

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Date: August 28, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Health Benefits of Stinging Nettle (Urtica Dioica) | Natural Cures

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Date: August 09, 2017 09:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Almost half of cannabidiol users stop using over-the-counter medicines, survey says

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Date: August 06, 2017 09:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The Best Natural Treatments And Medicinal Plants For Liver Detoxification

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Date: July 03, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: prostate cancer breakthrough: Combination of three plant-based nutrients found to MELT AWAY prostate cancer cells

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Date: July 02, 2017 09:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Hematuria: What Causes Blood in Urine?

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Date: June 28, 2017 07:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Compounds in Turmeric, Red grapes, Apple Peels, & Berries May Help in Treating prostate Cancer

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Date: June 12, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Why You Need Choline And How To Get It

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Date: June 11, 2017 07:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Starving prostate cancer with what you eat: Apple peels, red grapes, turmeric

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Date: June 01, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 7 disease-fighting foods to incorporate into your eating habits

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Date: May 21, 2017 11:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Expert calls for government to stop lying about cannabis

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Date: May 10, 2017 10:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: pros and Cons to Know About the Atkins Diet

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Date: May 03, 2017 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: prostate inflammation (prostatitis): Causes, symptoms, and treatment

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Date: April 16, 2017 06:44 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Heavy intake of antibiotics linked to deadly bowel cancer

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Date: April 16, 2017 01:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Health benefits of mushrooms: 10 interesting health benefits of mushrooms nobody told you about

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Date: March 28, 2017 11:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Easy Healthy Recipes || How to Make Avocado Smoothie

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Date: March 22, 2017 04:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Drop Toxic Sanitizers! They Cause Skin to Absorb 10X MORE of the Hormone Disrupting BPA. Instead, DIY the most Effective Hand Sanitizer

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Date: March 22, 2017 04:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: LOOK HOW IT IS EXPELLED TO THE LAST STONE OF THE KIDNEY WITH A HALF CUP OF THIS DRINK!!

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Date: March 20, 2017 04:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Walnuts can help improve sperm quality —Scientists

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Date: March 18, 2017 03:44 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 10 Amazing Benefits That Make Green Tea The Healthiest Drink In The World

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Date: March 18, 2017 01:44 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Medical cannabis - The healing pros and cons

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Date: March 18, 2017 04:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Are walnuts the key to fighting prostate cancer? Researchers think so

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Date: March 12, 2017 04:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Cannabidiol (CBD) Inhibits Cancer Growth According to Medical Researchers, Announces Phillip Fry

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Date: March 10, 2017 12:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: List Of 16 Best Vitamins To Increase Metabolism

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Date: February 08, 2017 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Does depression boost the risk of cancer death?

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Date: February 08, 2017 10:19 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Health Benefits Of Corn Silk | Health Tips Education

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Date: January 03, 2017 08:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 6 surprising ways Christmas is actually good for your health

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Date: December 23, 2016 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Men's prostate Health – Best Vitamins, Supplements & Tips?

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Date: December 18, 2016 08:11 PM
Author: Darrell Miller
Subject: 4 Main Health Benefits Of Grapefruit

Grapefruits are fruits loved by many. Most people prefer eating this fruit mainly because they're rich in vitamin C. Besides that, grateful also has a number of health benefits that you should probably know about. This fruit is found in 3 different pulps; white, red or pink pulps. But nevertheless, they still offer similar benefits. I'm going to show you some of the most unexpected health benefits of grapefruits that you probably need to be aware of. 

Benefits of Grapefruit

Boosts metabolism

Grapefruit is a good remedy for those who want to shed some weight. A high metabolism is good because it will help you burn down excessive fat in your body even when you're resting. Eating grapefruit before meal can tremendously help you lose some weight. This is because grapefruits have a high amount of enzymes and less sodium which helps to burn excessive fat easily.

Reduces the risk of having kidney stones

According to reports, grapefruits reduce the risk of having kidney stones. Naringenin is a natural compound that regulates protein a called PKD2 which is responsible for the prevention of kidney cysts. The antioxidant effects will also prevent the kidneys from swelling which is mainly caused by fluid retention.

Strengthen the immune system

Typically, any fruit that is rich in vitamin C will support and strengthen the immune system. This vitamin also works in conjunction with other micronutrients in order to provide the body with good nourishment. Having high levels of the vitamin will help reduce cold symptoms. This will make it easier to control allergies since vitamin C reduces histamine levels.

Protects against cancer

Grapefruits have also been linked to reducing the chances of getting certain cancers. Recent studies have discovered that the fruit can help repair/restore damaged DNA found in prostate cancer cells. The natural compound called naringenin stimulates repair of DNA in the cancer cells and will prevent your body from cancer. Grapefruits have been linked to reducing the risk of cancer like breast cancer, cancer of the stomach, colon, esophagus as well as bladder.

Related Products

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Date: December 17, 2016 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Collusion: DEA bans plant medicines, then Big Pharma patents them for profits

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Date: December 15, 2016 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Enzyme that digests vitamin A also may regulate testosterone levels

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Date: December 07, 2016 04:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: High-dose vitamin C reduces inflammation in cancer patients, study shows

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Date: November 24, 2016 06:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Matcha, kiwi will give your skin a glow

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Date: November 14, 2016 10:20 PM
Author: Darrell Miller
Subject: The Health Benefits of Grape Seed Extract

Grape seed extract is most commonly a waste product produced by the grape juice and winery industry. This is because grape seed extract doesn't go into finished drinks. Grape seed contains a wide variety of health-enhancing ingredients like protein, carbohydrates and lipids (healthy fats).

Immune system

Vascular Endothelial Health

High Blood Pressure

High Cholesterol

Pancreas

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3445)

Date: November 04, 2016 02:04 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 5-foods diabetics should add to their diets

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Date: October 29, 2016 11:29 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Hair Growth Vitamins - Are you going bald?

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Date: September 28, 2016 07:50 AM
Author: Darrell Miller
Subject: Maca Root And Your Health

Maca, (Lepidium meyenii) also Peruvian herb is a biennial herb indigenous to Andes, Peru. It’s also grown in Brazil and Bolivia. It’s cultivated for its fleshy hypocotyl and tap root which is a root vegetable and a medicinal herb.

Brief history

For over 2000 years, Maca root has been used by the ancient Incan culture for medicinal uses. They highly revered the plant for its legendary ability to offer mental clarity and energy as well as enhancing sex drive.

Today, Maca root is medicinal and health benefits such as:

•  Hormonal balance to improve menopause and PMS symptoms in women as well as mood and fertility
•  Improving sperm production, volume, and mobility in men
•  Reduces enlarged prostates
•  It’s used as an aphrodisiac to improve sex drive
•  Increasing bone density especially in women

Maca root and Energy improvement

Maca contains vitamins, fatty acids, proteins, and minerals. These are elements to naturally support energy supporting as well as aid in injury recovery. Those who have used maca root in powder form have testified that it makes them awake, driven and energized. They even prefer it over caffeine as it doesn’t give jitters.

Clinical studies have revealed that maca is useful in maintaining positive energy levels and reducing anxiety and depression. It’s also important in regulating the hypothalamus, which improves the functioning of pituitary glands and thus balancing focus and energy. Researchers believe this is enhanced by balancing blood sugar levels.

Maca root holds many health benefits, if you are over the age of 50, you should be taking maca root daily to help balance hormones and feel better.

Reference URLs

https://draxe.com/top-5-maca-root-benefits-and-nutrition/

//www.globalhealingcenter.com/natural-health/7-benefits-of-maca-root-for-women/

//www.webmd.com/sex-relationships/guide/the-truth-about-maca

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3316)

Date: September 17, 2016 09:58 AM
Author: Darrell Miller
Subject: Do you need to regulate hormones ? Experience Chaste Berries Powerful Effects

Would you believe that a simple berry could be the solution to hormone normalization and regulation? The Chaste berry has been shown to treat suffering from symptoms of menopause, menstrual irregularities, pre-menstral syndrome, and infertility. However, Chaste berries benefits do not end with women as the berry has also seen use as a natural way to balance hormones in men and may actually prevent prostate cancer.

Chaste berry, also known as vitex, has the ability to regulate and stimulate anterior pituitary functions and has been shown to restore normal estrogen to progesterone levels in women. This is accomplished by attaching to dopamine receptors and decreasing output of prolactin. It is this process that allows Chaste berry to treat the multitude of different hormonal issues that it does and ultimately regulate and normalize hormone levels.

In conclusion, there are many different uses for Chaste berry when it comes to hormonal health. For women the berry has shown successful use as a treatment for PMS pains, fertility challenges, and abnormal menses. In men, Chaste berry has been used to prevent prostate cancer and balance hormones. Chaste berry has also been indicated to effectively treat acne in both male and females. Who would’ve thought you could get all that from one little berry?

References:

//www.organicauthority.com/health/balance-hormones-naturally-with-chasteberry.html

//www.blossomclinic.net/2012/01/04/chaste-tree-berry-vitex-a-girls-best-friend-2/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3296)

Date: September 28, 2015 08:53 PM
Author: Darrell Miller
Subject: What Is Thymoquinone Found In Black Seed Oil?

The black seed oil is obtained from the seeds of the Nigella Sativa plant. The black seeds, also known as the black cumin, were used by the ancient Egyptians because of their ability to cure a variety of health conditions such as toothaches, headaches. It was also used as a dietary supplement. Additionally, the black seed oil is effective in ensuring a stable immune system as well as combating diseases that affect the immune system. The medicinal power of this oil emanates from its active ingredient, thymoquinone.

Thymoquinone is an active compound that contains anti-inflammatory, anti-cancerous, and antioxidant properties. Research indicates that thymoquinone can thwart the cancerous cells in the colon, pancreases, and prostate. Because of the healing properties of this compound, black seed oil, therefore, remains useful as far as human health is concerned.

Some of its benefits includes:

• Treating cancer

The black seed oil has been used for a long time to treat cancer. According to the research from three Chinese researchers and four Arabian scientists, black seed oil contains the right anti-cancer properties. They noted that the black seed oil was used as a traditional medicine for many years. The active compound, thymoquinone, contained in the black seed oil is effective against many other diseases such diabetes, kidney, asthma diseases.

• Fever and flu

Taking a teaspoon of the black seed oil can help cure fever or flu. It causes the body to sweat for it to recover from the illness.

• Curing insomnia

Research indicates that black seed oil can help a person sleep well if suffering from insomnia. One teaspoon of the oil put in a warm drink before sleeping helps to eradicate the problem.

• Curing arthritis

Studies show that the black seed oil responds positively to the treatment of Rheumatoid arthritis. Further studies indicate that this oil helps reduce inflammation in the joints and the stiffness that occur in the morning.

• Curing asthma and cough

Black seed oil is an anti-bacterial and anti-inflammatory, and it is ideal for treating coughs and also addressing asthma symptoms. It achieves this by relaxing the bronchiole tube muscles.

• Radiation treatment

According to researchers from Turkey, black seed oil is potentially helpful to people receiving radiation treatment for cancer.

The thymoquinone compound in black seed oil makes this oil essential to the health of human beings. Consumption of the black seed oil will keep you off from most cancer infection and diseases.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3224)

Date: September 03, 2015 01:59 AM
Author: Darrell Miller
Subject: What Herbs Support A Healthy prostate

prostate health is vital for any male's well-being.  Keeping your prostrate free from complications is a result of good hygiene, proper diet and most importantly, living a healthy lifestyle.  The bad news is that some of the prostate complications such as prostate cancer can cause death.  The good news is that there are better remedies to prevent that from happening, reduce the effects of these complications and lastly, do away with them completely.

From pharmaceutical pills to natural supplements, there are more than enough remedies for prostate complications in the market. However, if you are looking for something safe to use, then it is always advisable to choose natural supplements, herbs or anything that is safe from toxic chemicals.  In our case, we will be dealing with herbs that support prostate health.

What Herbs Support A Healthy prostate?

• Saw Palmetto.  Saw Palmetto is simply a small palm with fan-shaped leaves from the southeastern United States. Saw Palmetto is known to treat enlarged prostate or hyperplasia (BPH). Some studies show that they can also reduce the urge to urinate at night and also, enhance urinary flow.

• Pygeum.  Used to treat several complications, Pygeum contains extracts from the bark of Prunus Africana. It is known to work best when it comes to treatment of enlarged prostate. Just like saw palmetto it is also known to reduce the need to urinate at night and at the same time improves the flow of urine.

• Beta-sitosterol.  Beta-sitosterol can be found in vegetables, nuts, seeds and fruits. Beta-sitosterol has several health benefits that include treating colon cancer, cervical cancer and more. It is also known to be among the best solutions for an enlarged prostate.
• Lycopene.  Lycopene is simply a red carotenoid pigment that is found in fruits, berries, and many other fruits. Apart from being the best remedy for several complications, research shows that Lycopene also has the ability to cure prostate cancer.
• Stinging Nettle Root. Stinging nettle root is among the best remedies for urination problems that include, frequent urination, painful urination, bed time urination and more. They are also considered to be among the best solutions in dealing with an enlarged prostate.

In summary, keeping your prostate healthy means improved urination flow and more. It also means, creating a barrier between your prostrate and several diseases such as prostate cancer. The herbs mentioned above are among the best and the safest ones to use.

References:
//www.webmd.com/vitamins-supplements/ingredientmono-939-beta-sitosterol.aspx activeingredientid=939&activeingredientname=beta-sitosterol
//www.webmd.com/vitamins-supplements/ingredientmono-664-stinging%20nettle.aspx?activeingredientid=664&activeingredientname=stinging%20nettle
//www.webmd.com/men/prostate-enlargement-bph/supplement-guide-saw-palmetto
//www.globalhealingcenter.com/natural-health/pygeum-bark-can-help-prostate-health/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3208)

Date: July 21, 2015 06:18 AM
Author: Darrell Miller
Subject: Protect The prostate With Herbs: Curcumin

prostate cancer is considered as the most common form of cancer affecting men. There are various remedies available to address this condition and one of the most notable are natural herbs. Pygeum, saw palmetto and garlic are some of the herbs that fall under this category but perhaps one of the most important natural agents is curcumin.

Curcumin is a natural agent normally derived from the Indian spice, turmeric. It is responsible for yellowish color in turmeric powder.

So how does it help to fight cancer?

According to a research carried out at the Anderson cancer center, curcumin is an antioxidant and also has anti-bacteria and anti-viral properties. It also has the capacity to stop the action of an enzyme known as cox-2 known to cause chronic prostate inflammation bringing about cancer.

Curcumin also has the capacity to inhibit, vascular epithelial growth factor. You see, all tumors need an active blood supply, by inhibiting the epithelial growth factor, blood supply is cut to the tumor preventing its growth.

Curcumin has been shown to have the ability of killing cancer cells and also prevent the regrowth of cancer stem cells which usually lie at the center of many tumors that cause prostate cancer.

//www.canceractive.com/cancer-active-page-link.aspx?n=1571

//drgeo.com/perhaps-the-most-important-herb-for-prostate-cancer-protection

Read More

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Date: July 20, 2015 01:32 AM
Author: Darrell Miller
Subject: Three Immune Boosting Mushrooms You Can't Ignore

Mushrooms are plants that belong to the fungi kingdom.  These plants are not classified as vegetables, they provide essential and vital nutrients to our bodies. It is a common knowledge that the key to building strong immune systems and getting enough minerals and vitamins in the diet is by supplementing a variety of colorful fruits and vegetables, the more the color the better.  This knowledge has however left mushrooms, which offer a wide variety of nutrients and antioxidants to our bodies, in the dark.  In many cases, foods are only considered to be nutritious if they are colored. However, this is not true for mushrooms.

Let's take a look at three most common mushrooms that positively impact the overall immune system and how they make it happen.

Maitake Mushroom

Maitake mushrooms are common in Asian countries.  This mushroom subspecies has shown effectiveness in the treatment of cancer. They can also be used to treat some side effects that are commonly associated with various chemical treatments such as chemotherapy for cancer. It is also used in the other conditions such as chronic fatigue syndrome, HIV/AIDS, Hepatitis, high cholesterol, hay fever, weight loss, diabetes, hypertension and infertility due to poly cystic ovary syndrome.

How it works

This species of mushroom contains chemicals that might stimulate the immune system and help fight tumors. There is also evidence that it can also be used as an effective regimen in efforts to lower blood pressure, lower blood sugar levels, improve cholesterol levels. Studies have also shown that it is effective in weight loss management.

Reishi Mushrooms

Reishi mushrooms are a type of fungi that some people describe as "woody" and "tough". The fruiting body of this plant and the filaments connecting a group of mushrooms has been used greatly as medicine. The plant is also used to boost the immune system, lung conditions including bronchitis and asthma, viral infections such as swine flu, influenza and avian flu, heart disease.

It is also effective in maintaining other contributing conditions such hypertension, high cholesterol, liver disease and cancer. Other conditions where Reishi mushrooms are used are insomnia, stomach ulcers, chronic fatigue, herpes pain and poisoning.  In combination with other forms of herbs, they are also used in the treatment of prostate cancer.

How it Works

Reishi mushrooms contain a wide variety of antioxidants and chemicals that have potential benefits and effects on the immune system and activity against tumors.

Shiitake Mushroom

An extract made from this mushroom is used as medicine. Although it is used widely as medicine, it is also consumed as food. Shiitake mushrooms are used to lower blood cholesterol levels, boost t-cells and as an anti-aging agent.

How it Works

This type of mushroom contains chemicals that help in lowering cholesterol levels. It contains chemicals that keep cancerous tumors from getting bigger.

References:

1. //www.medicalnewstoday.com/articles/278858.php

2. //www.webmd.com/vitamins-supplements/ingredientmono-560-maitake%20mushroom.aspx?activeingredientid=560&activeingredientname=maitake%20mushroom

3. //www.healthline.com/health/reishi-mushroom-key-to-immortality#2

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3171)

Date: August 08, 2014 10:01 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can Low Selenium Affect Thyroid Functions?

What is thyroid glands

Human thyroid glands are small glands with a very important function. The major function of thyroid glands is to regulate body metabolism.

There are two main hormones produced by thyroid glands; thyroxin (T4) and triiodothyronine (T3). The secretion of these 2 hormones is based on the feedback mechanism of hypothalamus and pituitary glands. These hormones influence every body cells- they control the rate at which your body accumulates and uses fat, help to regulate body temperature and also heart rate. In addition, thyroid glands produce calcitonin, a very important hormone that regulates the amount of calcium in the body. There are the major types of thyroid diseases, Thyroid cancer, Hyperthyroidism, Hypothyroidism and Benign disease. But what is the role of selenium in thyroid functions?

Selenium deficiency

Selenium deficiency is not common in healthy adults, but it is common in people with digestive disorders causing low absorption, or those with severe inflammation arising from chronic infection. Research shows that low selenium does not cause illness by itself, but due to its role in immune functions, it makes a body susceptible to biochemical, nutritional and infectious diseases.

But this does not mean that selenium has no direct influence on thyroid functions. Adequate selenium supports the production of thyroid hormones, protects thyroid glands from the adverse effects of excess iodine in the body, and will also improve body metabolism.

Importance of selenium

Selenium is very important and it is always healthy to ensure your normal selenium level. For example, selenium supplements are used to treat autoimmune thyroid condition. Studies have found that selenium supplementation lowers thyroid inflammation. These findings are backed by the fact that selenium increases thioredoxin reductase and glutathione peroxidase activity, and also lowers the toxic concentration of lipid hydro peroxides and hydrogen peroxides which results from the production of thyroid hormones.

Selenium prevents thyroid tissue damage. Selenium is very important because it lowers the level of thyroid peroxides in the blood. In addition, selenium is vital for conversion of T4 to T3. T3 is the active form of thyroid hormones. Low T3 causes hypothyroidism.

How to obtain selenium?

If you think your body is deficient of selenium, it is good to seek medical care immediately. Thyroid glands are very important for the body functions. Selenium supplement is a good solution to thyroid function. But long term use of selenium supplement would cause other complications such as white blotchy nails, hair loss, gastrointestinal upsets, fatigue, irritability, garlic breath odor, and mild nerve damage. In addition, very high selenium in the body may cause hyperthyroidism. In addition, clinical test for use of selenium supplements has found that it predisposes users to the risk of prostate cancer. Though this has not yet been proven. This makes selenium rich foods the best way to increase the level of selenium in the body. Some of the food rich in selenium includes; crimini mushrooms, shrimp, tuna, cod, scallops, chicken, halibut, salmon, shiitake mushrooms, brazil nuts, lamb eggs, and turkey. Brazil nut is particularly very rich in selenium, taking one or two in a day will significantly improve the selenium level and also boost your immune system.

Is selenium important for thyroid function?

Yes, selenium level is very important and low selenium.

References

1. //chriskresser.com/selenium-the-missing-link-for-treating-hypothyroidism
2. //www.wellnessresources.com/health/articles/seleniums_vital_role_in_thyroid_hormone_function/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3155)

Date: August 01, 2014 05:29 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Liquid Calcium Citrate - An Overview of What to Discover

Calcium

While calcium is quite effective in conditions of improving health, it is valued very little without the addition of magnesium. Calcium in liquid type is much, much more potent than that of the tablet selection.

Absorption of calcium

Due to the fact liquid calcium is drinking water centered, it is virtually a single hundred % to be absorbed by the body. The reality of the subject is that much less than twenty five % of tablet based calcium is absorbed by the body.

Benefits of liquid calcium

The digestive process rewards immensely from liquid calcium magnesium. It is excellent for the relief of constipation, indigestion and heartburn. It gains the digestive procedure in other strategies as well and for greatest outcomes, it ought to be taken right after eating.

Calcium deficiency

It is a properly-recognized truth that insufficient quantities of calcium trigger osteoporosis. Calcium deficiency has dire penalties for little ones as it can lead to rickets in kids. Far more important in adults, it causes softening of the bony tissue. This is acknowledged as osteomalacia.

Symptoms of calcium deficiency

An individual can detect a lack of calcium in the body by the presence of tingling and or numbness all around the mouth and the fingertips. Calcium deficient persons will also knowledge painful aches and muscle spasms.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3151)

Date: June 30, 2014 09:54 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Homeopathic Remedies

Homeopathic remedies

The utilization of homeopathic remedies is an option to tried and true therapeutic medicine. A moderately new limb of solution, it utilizes a comprehensive methodology for treating side effects of a condition. Homeopathic remedies are developing in prominence, generally on the grounds that tried and true therapeutic medicine has been frequently unsuccessful the root issue of a condition, not simply side effects.

Homeopathy- -the act of homeopathic drug -was initially utilized by Dr. Samuel Hahnemann in Germany in the eighteenth century. It utilizes the antiquated idea of "like cures like," an idea that is much the same as that of inoculation. Its reason is that if a substantial amount of a substance causes, manifestations in a sound individual, then a little measure of that same substance will cure an individual experiencing those indications.

Speculations

The speculations about exactly how homeopathic remedies function are backed by real clinical trials and in practice. Professionals who use homeopathic remedies accept that that the human body is always striving to achieve a state of regularity. It responds to transform it deciphers as "fixable." Homeopathic remedies work by utilizing a little weakened measure of a substance to fortify the body's recuperating systems. The conviction is that this will trigger the invulnerable framework to assault the illness and the body will come back to an ordinary, sound condition.

Methodology

Homeopathic meds are accessible over the counter, however an assessment by a confirmed homeopathy specialist is prescribed before curing toward oneself. Throughout a homeopathic assessment, side effects of an infection are deliberately watched and reported, alongside insights about the general conduct of the patient. Insights about the persistent's preferences and aversions, general demeanor and identity characteristics are contemplated. A homeopath utilizes these perceptions to guide the patient in picking the best cure and dose for his specific condition.

Contemplations

There is no genuine experimental confirmation that medication with homeopathic remedies is powerful. On the other hand, the therapeutic group recognizes that it is conceivable that some of these remedies may be useful and it is for the most part concurred that they are totally protected. Homeopathy is still an extremely youthful extension of the drug. Extra experimental study is required to keep in mind the end goal to accommodate clashing convictions concerning its adequacy.

Why use Homeopathics?

Homeopathy is the second most broadly utilized arrangement of pharmaceutical as a part of the world. Its development in ubiquity in the United States has been around 25 to 50 percent a year all through the most recent decade.

This achievement is powered by a few elements:

• Homeopathy is greatly powerful. At the point when the right cure is taken, results might be fast, finish and lasting.

• Homeopathy is totally protected. Indeed infants and pregnant ladies can utilize Homeopathy without the risk of symptoms. Homeopathic remedies can likewise be taken nearby other pharmaceutical without delivering unwanted reactions.

• Homeopathy is common. Homeopathic remedies are ordinarily focused around characteristic fixings.

• Homeopathy works in concordance with your insusceptible framework, dissimilar to some customary meds which stifle the invulnerable framework.

• Homeopathic remedies are not addictive - once alleviation is felt, you ought to quit taking them. On the off chance that no alleviation is felt, you are likely taking the wrong homeopathic cure.

• Homeopathy is comprehensive. It treats all the side effects as one, which in reasonable terms implies that it addresses the reason, not the indications. This frequently implies that side effects handled with Homeopathy don't repeat.

• Homeopathic remedies are sheltered items that create no reactions. The doses are so little and weakened that they are totally safe. Additionally, some feel that the significant serenity connected with utilizing regular substances helps a general feeling of prosperity that helps help the resistant framework and empowers the body to heal itself.

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Date: June 13, 2014 09:25 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Learn about the prostate

Introduction:

The human prostate is a walnut-sized gland that is located between the bladder and the penis. It is just in front of the rectum with the urethra running through the center from the bladder to the penis, letting out urine off the body. The prostate gland secretes fluid that is useful in nourishment and protection of sperms. The prostrate squeezes this fluid into the urethra during ejaculation and it comes out with sperms as semen.

Article Body

However, the prostate is faced by some conditions that lead to its dysfunctions. Some of the main conditions are.

prostate cancer:

This is one of the major cancers affecting men and it kills one in every thirty-five men. Some of the treatments used to treat it are, chemotherapy, surgery, radiation and hormone therapy.

prostatitis:

This is inflammation of the prostate, which is caused by infection. It is usually treated with antibiotics.

Enlarged prostate:

This usually affects older men above the age of fifty. Its signs are difficulty in urinating that increases with age. It can be treated through medication or surgery. This usually affects older men above the age of fifty. Its signs are difficulty in urinating that increases with age. It can be treated through medication or surgery.

It is of much importance to keep the prostate healthy due to its major functions. The general function of the prostate is to secrete a slightly alkaline fluid that is white in color constituting 50-70% of the semen volume together with spermatozoa and seminal fluid. The prostatic fluid is expelled in the first ejaculate fractions together with most of the spermatozoa. Maintaining good health of the prostate for example by taking foods rich in lycopene mainly found in tomatoes lower the risk of developing prostate cancer.

The pygeum africanum is made from the bark of the African palm tree while the saw palmetto is made from ripe berries of the plant serenoa repens. They are both used for the treatment of benign prostatic hyperplasia. Pygeum may reduce symptoms such as nighttime urination, urinary frequency and residual urine volume. But despite that the pygeum is also proposed for prostatitis, impotence and male infertility. This makes it better than saw palmetto. Saw palmetto has mineral selenium and vitamin E while pygeum africanum has zinc.

Sources

1. //www.webmd.com/urinary-incontinence-oab/picture-of-the-prostate
2. //www.med.nyu.edu/content?ChunkIID=21851
3. //en.wikipedia.org/wiki/Saw_palmetto_extract

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Date: June 12, 2014 08:54 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Different Types of Royal Jelly

What is a royal jelly?

Royal jelly is a gelatin-held substance, which is normally emitted from the cephalic organs of the working drones for the expansion of the ruler honeybee. The hugeness of this white substance for ruler honeybee could be comprehended with a truth that without it, the monarch bumblebee and other working drones will not prosper.

Benefits of royal jelly

The concoction component of illustrious jam is that it is a water-based emulsion of lipids, proteins, sugars and assortments of elements. Further, there are sure parts of it that work against diverse sorts of bacterial executors. It is additionally paramount that the sugar synthesis of bumblebee jam is indistinguishable to those found in glucose and nectar fructose.

The counterfeit detailing of illustrious jam is carried out through distinctive conversion stages, for example, transforming it into different structures like cases, mixture, chewable tablets and fluid. The readiness of the substance is of two sorts, specifically - stop dried and new.

A few producers make offers of crisp jam straightforwardly to clients. In the end, the clients get profits as far as benefitting bumblebee items holding well being profits and sturdiness. Naturally, with such strong item, the expense of purchasing a new one is unreasonable purchase for the clients.

One of the wonderful sorts is stop-dried substance. This is a direct result of the reason that the stop-dried sort holds complete well being support profits alongside providing for your long lifespan of the item. That intends to say, different sorts of it cannot provide for you a life span ensure as stop dried jam provides for you. Those results of diverse sorts of regal jam are effectively perishable and at a certain stage, their possibility lessens continuously in this way, providing for you no wellbeing profits and the items get valuable for you. You ought to realize that it can additionally be stop dried into powder and therefore pressed into containers.

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Date: May 27, 2014 05:23 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Does Broccoli Really Fight Cancer?

What is a broccoli?

Cruciferous vegetables such as broccoli is known to have numerous health benefits within the body. In addition, many studies have proved that broccoli has another element known as sulforaphane that has cancer-fighting properties.

Benefits of broccoli

A recent study by the Oregon State University, suggested that sulforaphane is a powerful antioxidant in broccoli and many other cruciferous vegetables do have the power and the ability to kill cancer cells, thus leaving the prostate cells unaffected.

Sulforaphane is also another potent antioxidant that has the ability to inhibit HDAC enzymes known as histone deacetylase and play a vital role in suppressing tumor-like genes thus making a perfect solution to cancer treatment. HDAC in Cruciferous vegetables such as broccoli is known to have numerous health benefits within the body. In addition, many studies have proved that broccoli has another element known as sulforaphane that has cancer-fighting properties.

A recent study by the Oregon State University, suggested that sulforaphane is a powerful antioxidant in broccoli and many other cruciferous vegetables do have the power and the ability to kill cancer cells, thus leaving the prostate cells unaffected.

Sulforaphane is also another potent antioxidant that has the ability to inhibit HDAC enzymes known as histone deacetylase and play a vital role in suppressing tumor-like genes thus making a perfect solution to cancer treatment. HDAC inhibition is another very promising cancer treatment and many researchers have found that it is associated with broccoli. Cancer is often characterized by the inappropriate cell growth, however, HDAC inhibitors has the ability of restoring cells to normalcy in terms of function and thus the most effective cure of cancer.

Other studies have also demonstrated the cancer-fighting ability of the cruciferous vegetables. In the year 2009, Victoria Kirsh., of Toronto Cancer Care Ontario and her team discovered that eating vegetables and fruits in general was associated with the decreased prostate cancer risk, making it one of the best ways of enhancing health. This remarkable compound in broccoli is among the strongest anti-cancer elements in the body.

It is important to recall that you cook your broccoli in the best way possible since this will preserve the elements that helps in fighting cancer. In addition, Broccoli has myrosinase that helps in the formation of sulforaphane. You need to remember that Myrosinase is an element that can be destroyed through overcooking the broccoli. You should only steam it for 2 to 4 minutes. In conclusion, the above information should convince on the incredible ability to cure the cancer cells that are found within the body.

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Date: May 18, 2014 11:06 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Adrenal Glandular Supplements

Healthful supplements

Healthful supplements can help keep up the strength of your organs by guaranteeing legitimate working of the glandular framework. Like all organs, the organs need healthful backing. Particularly when anxiety exhausts the assemblage of put away supplements. Your organs produce and discharge substances into the body for the body’s utilization. A breakdown or an irregularity of any one glandular substance can make gigantic issues around the body.

Organs has two classifications.

The exocrine organs - open onto a surface of an organ; or other structure, through a pipe. Samples of the exocrine organs incorporate the salivary of the mouth and the sweat and oil organs of the skin. Other exocrine organs are found in the kidneys, the mammary organs and the digestive tract.

The endocrine organs - are ductless, in this way emitting the substances they prepare (hormones) straightforwardly into the circulation system. By emitting hormones the endocrine organs help manage almost all substantial capacities. Samples of the endocrine organs incorporate the adrenal (on the kidney), the pancreas (behind the stomach), the pituitary organ (at the base of the mind), the pineal organ (connected to cerebrum), sex organs (testes/ovaries), the thymus organ (underneath the thyroid) and the thyroid and parathyroid organs (in the neck).

Supplement source

• Kelp - is rich in dietary minerals and iodine, which is essential for thyroid capacity. Consume to 200 milligrams every day.
• L-Arginine - an amino corrosive that expands the movement and size of the thymus organ. Take 500 milligrams every day.
• L-Glycine - an amino corrosive that is key for the wellbeing of bone marrow, spleen and the thymus organ. Take 500 milligrams every day.
• L-Tyrosine - an amino corrosive that is paramount to the capacity and wellbeing of the adrenal, thyroid and pituitary organs. Take 500 milligrams every day.
• Manganese - is put away and utilized by the cerebrum, kidneys, liver, lungs, pancreas and prostate organ. It is critical to the generation of thyroxine, the hormone that directs digestion system and is vital for typical development and advancement. Take as guided on name.
• Silica (silicon) - helps in recuperating the organs and tissues. Take 500 milligrams twice day by day.
• Vitamin A in addition to common beta-carotene - supplements that build immune response processing and sustain the thymus organ. Organs with conduit frameworks require these supplements. Take as coordinated on marks.
• Vitamin B complex - is particularly imperative on the off chance that you are under anxiety. B vitamins work best when all has taken together. Take 100 milligrams twice day by day.
• Plus additional riboflavin (B2) - essential to the strength of the completely glandular framework. Take 50 milligrams three times day by day.
• Plus additional pantothenic corrosive (B5) - known as the opposition to push vitamin. Take 50 milligrams three times day by day.
• Vitamin C - is vital for adrenal organ capacity. Take 1500 milligrams every day.
• Zinc - is required for pancreas and thymus wellbeing and required by the safe framework. It is particularly imperative for the sex organs.

Maintain a strategic distance from perk and soft drinks, which can dispose of vitality in your body and make you feel more tired. Furthermore, you ought to change your lifestyle. For instance, take a stab at dozing in until nine in the morning if at all conceivable and verify you practice and do exercises that minimize stress. Consume customarily and does something fun while staying far from contrary individuals and movements.

Caution in taking the supplement

In addition, you may want to take the fatigue supplements each day to help you recover from this glandular dysfunction and make you feel more energetic. If you have this syndrome, then there are supplements that you can take to help address the problem. Before taking any enhancers, contact your doctor and have him or her run a test first to see if you suffer from adrenal fatigue syndrome.

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Date: May 17, 2014 01:25 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: A Sulfur Supplement Is Necessary For A Healthy Body

Benefits of sulfur

The human body obliges sulfur for bones, joints and an assortment of capacities. Sulfur is needed for ordinary day-by-day capacities and in bigger amounts when the body's frameworks are focused on, repairing harm or battling a malady. A sulfur supplement is required that can likewise offer a large number of numerous wellbeing upgrading profits for fighting an extensive variety of wellbeing issues, expanding imperviousness to sicknesses, and making wellbeing and prosperity. It is additionally required for detoxification of the body in uprooting poisons and mechanical chemicals that the body regularly assimilates once a day.

An approach to fulfill these needs is with a day-by-day admission of MSM (Methyl Sulfonyl Methane). MSM is the main bio available manifestation of sulfur, a macro mineral that is utilized within critical sums in the body. An uncommon dietary supplement is likely the most noteworthy finding since Vitamin C, and is presently the most prominent supplement in nourishment. It is intended to help joint conditions, for example, osteoarthritis, sprains, tendinitis, bursitis and games related wounds. It is non-poisonous, non-allergenic and does not meddle with different sorts of pharmaceuticals and supplements, and offers a long arrangement of wellbeing profits for the body.

Where to find sulfur?

Sulfur is fundamental in the ordinary consistently working of the human body. It has been utilized for many years to cure skin sicknesses, joint and bone conditions and numerous different afflictions. In spite of the fact that sulfur is gotten from nourishment sources and the human body does not handle it, in instances of great insufficiency it could be acquired by dietary supplements. Sulfur makes up pretty nearly 0.25% of body weight and is a vital some piece of all living cells. It is key in the counteractive action of numerous issues and must essentially be acquired from sustenance or wellbeing supplements.

Sulfur could be found in numerous skin balms, bar soaps, salves and creams. It is been demonstrated to be valuable in the medicine of pimple inflammation. It is utilized as an element within the medication for other skin related issue, for example, scabies, warts, and likewise for dandruff because of the antifungal, antibacterial properties of sulfur. Results of sulfur have been utilized to upgrade the procedure of wound recuperating, which was its motivation in the Trojan wars.

What are the benefits of MSM

MSM is the wealthiest wellspring of natural sulfur accessible and is essential in the creation and recovery of tissue. It is found in and utilized by every cell as a part of the body. It expands vitality, readiness, mental placidness and improves the capacity to focus. It remembers the manifestations of joint pain, carpal tunnel, tendonitis, bursitis and unending weakness. Sulfur has an alternate, positive impact on all the frameworks in the human body. MSM causes quick detoxification of the body's tissues by making the cell dividers more porous, making it simpler for the body to ingest supplements and to dispose of poisons by flushing them out of the body. Hormones, compounds, antibodies and cell reinforcements rely on upon MSM for their day-by-day capacities.

MSM is a non-medicine supplement that can help with joint issues running from a slight solidness to extreme torment. Its general profits helps with wellbeing issues, for example, joint inflammation, unfavorable susceptibilities, gastrointestinal, PMS, skin break out, lung issues, muscle torment, parasite, a few diseases, heart smolder and blockage, to name a couple. It is an exceptional dietary supplement that could be utilized for a mixture of requisitions, for example, hostile to aggravation, body corrosive decrease, expanding flow, sound connective tissues, lupus, breast and colon diseases, diabetes, eye wellbeing, anxiety and mental issue.

Studies have indicated that MSM Capsules help joint adaptability, decrease firmness and swelling, and diminish torment connected with maturing and damage. They have been utilized to help with ceaseless agony, joint inflammation, joint irritation, rheumatoid joint pain, osteoporosis, bursitis, tendonitis, musculoskeletal ache, muscle issues and then some. These containers can make the skin look more youthful and increment vitality levels. MSM is copious in nature, yet the wealthiest characteristic sources just give it at levels of a few parts for every million. Nourishment sources are prepared which exhausts characteristic sulfur, making a MSM supplement vital, and these containers have not demonstrated any negative reactions.

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Date: April 26, 2014 10:03 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Are Laxatives Safe For Your?

Laxatives

Herbal laxatives could promote bowel activity with mild purgation. They are usually used when there is a blood toxicity, constipation, an infection that cleansing of people bowel is needed, insufficient fiber in diet, a skin condition which caused by insufficient elimination, gallstones or hypertension.

Common laxatives

The most common laxative herbs used are senna, cascara sagrada, sesame, psyllium and milkweed. Milkweed or Asclepias syriaca is an old home remedy for warts, and medicinally important in heart disease treatment. The seed of Psyllium contain copious amounts of the mucilage, which are able to treat constipation, diarrhea and act as an effective and safe weight loss aid.

Why Would You Use Laxatives?

For relief of constipation you might suppose to use laxatives. Constipation is a gastrointestinal disorder, which make result in fewer or difficult bowel movements. Low fluid or fiber intake is the common causes of constipation. You will discover that bulk-forming laxatives are usually recommended for first aid when you have a constipation problem that will draw fluid into your intestines. However, it is not recommended to use laxatives in  long-term, because it could give you harmful side effect.

The pros and Cons of Taking Laxatives

Laxatives were used for conditions like irregularity, painful elimination and hard stools. For temporary use laxatives are help to treat some chronic condition and invaluable. However, using laxatives for long-term use may give you several risks: cramping, bloating, nausea, gas and diarrhea. The most important risk you might want to know, is your body will be dependent on that herbs. It is an important option to consult to your doctor when having a risk of laxatives. Since there are some risks of using laxatives, you would like to try the alternatives of laxative when you are planning to use in a long term. Here are some valuable alternatives: Fiber rich food, drink plenty of water daily and exercise regularly.

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Date: April 20, 2014 08:25 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Boswellic Acid To The Body

Benefits of boswellia

Rarely do people bank on herbs for treatment. Chemically manufacture medicines have taken over. However, what makes Boswellia herb very important? This herb has been used for a very long time. It is extracted from the Boswellia serrate tree. This herb is popular among other pharmacological medicines because of its medicinal values of reducing the effect of inflammation and inflammation related diseases.

What is inflammation?

Our body goes through very complex biological processes to keep us healthy. Inflammation is one of them. Inflammation has been the response action that the body takes towards an intruder. The body does this by producing prostaglandins and leukotriene; they are otherwise called inflammation mediators. Most of the time, the intruder can be harmful stimuli or pathogens and damaged cells. The body responds by causing acute pain in places like toes and fingers. Besides the pain, heat, swelling, redness and loss of function are signs of inflammation. Note that inflammation is not an infection.

Examples of inflammatory disease

Examples of inflammatory diseases are bronchial asthma that leads to narrowing of the respiratory tract and makes breathing difficult. Diabetes, type 1 is an inflammatory disease that is caused by the inflammatory mediators. They eat up the pancreas until it is exhausted. Production of insulin to counter diabetes will be affected largely.

How boswellia works

Boswellia releases boswellic acid. This is the main ingredient that is used to fight and heal inflammation. It does this by suppressing the release of prostaglandins and leukotriene. Bowellic acid comes in many forms. Acetyl-11-keto-B is one example that when released, inhibits the synthesis of enzymes that will produce leukotriene hence lead to inflammation. Constant use of this herb heals and prevents the body from inflammation diseases.

Besides healing inflammation diseases, boswellia reduces the effects of brain cells tumor and colon cancer. The herb can be used to activate tumor suppression genes, a genes that will control and eventually reduce the growth of cancer cells.

Sources

1. //medlicker.com/105-health-benefits-of-boswellia/

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Date: April 17, 2014 10:47 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: A Guide About beet roots.

History of beet

Beets are certainly historical. Originally, the sweet reddish beetroot that majority of people think of to be a "beet" today had not been cultivated till era involving historical Rome. By the exact nineteenth century, however, the natural sweetness of beets had become appreciated and beets grew to become used as a method to obtain sugar.

Health improvements about beet root base.

a) Lower Blood Pressure

Drinking beet juice can assist to lower blood pressure. One study discovered which drinking a single wine glass concerning beet juice minimal systolic blood pressure by simply typically 4-5 items.

b). Enhance Ones Stamina

If you choose a boost to let it become through your current subsequent training, beet juice may again prove valuable. Those who consumed beet liquid before exercise had an opportunity to exercise for approximately aid 16 pct longer. 4 The leading benefit is thought to also be connected with nitrates turning in nitric oxide, which can slow up the oxygen charge connected with low-intensity exercise and moreover enhance tolerance in order to high-intensity determine.

c) Anti-Cancer Qualities

The powerful phytonutrients that supply beets their strong crimson color can assist to ward off melanoma. Research has found which beetroot remove reduced multi-organ tumor formations in lots of different animal designs when administered in water, for instance, while beetroot extract is normally being studied for easy use within treating human pancreatic, bust line, and prostate varieties of cancer.

d) Rich inside Valuable Nutrients and Bedding

Beets are excessive throughout immune-boosting nutritional C, dietary linens, and essential minerals for instance potassium (essential intended for healthful nerve along with muscle function) along with manganese (which is useful for your bones, liver, kidneys, and in addition pancreas). Beets in addition support the vitamin foliate, which helps slow from the risk of beginning complications.

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