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NSAIDs vs. Curcumin: Which One Relieves Joint Pain Without Stopping Healing?   
Date:
September 14, 2026 11:22 AM
Comparative Analysis of NSAIDs versus Curcumin in Musculoskeletal Tissue RepairPrimary Biological Mechanisms and Pharmacological TargetsManaging soft tissue and joint injuries presents a persistent therapeutic challenge in musculoskeletal medicine. Acute inflammation triggers pain, localized swelling, and mechanical disability, which routinely drives patients toward pharmacological relief. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, celecoxib, and diclofenac have served as primary clinical interventions. While these synthetic agents effectively extinguish acute pain signals, expanding cellular and clinical research indicates that their biochemical mechanism interrupts the fundamental repair cascades required for long-term connective tissue healing. In contrast, curcumin - a natural polyphenolic compound derived from the rhizomes of Curcuma longa (turmeric) - exhibits a distinct, multi-targeted regulatory profile that calms hyperactive inflammation while protecting the structural components of cartilage and tendon tissue.The functional divergence between these two compounds becomes clear when considering an intuitive mechanical analogy. Tissue trauma resembles damage to a commercial building, where initial inflammation functions as the construction and demolition crew tasked with clearing rubble, stabilizing the foundation, and laying down fresh structural framing. NSAIDs function like abruptly cutting electrical power to the entire work site: the noisy machinery stops instantly and the immediate disturbance ceases, but the construction workers lose the power necessary to clean the debris and erect permanent walls. Conversely, curcumin operates as an experienced site manager: it silences unnecessary chaos and prevents site vandalism while ensuring that the skilled workers - specifically chondrocytes in cartilage and tenocytes in tendons - remain fully active, supplied, and capable of completing the restoration. At the cellular level, NSAIDs exert their effects through the catalytic inhibition of cyclooxygenase enzymes, categorized as constitutive cyclooxygenase-1 (COX-1) and inducible cyclooxygenase-2 (COX-2). Membrane phospholipids damaged during injury release arachidonic acid, which COX enzymes convert into pro-inflammatory lipid mediators known as prostanoids, most notably prostaglandin E2 (PGE2). Nonselective NSAIDs block both isoforms, while selective coxibs specifically target COX-2. By shutting off PGE2 production, NSAIDs rapidly elevate pain thresholds and blunt localized swelling. However, because PGE2 also functions as a vital signaling cue for cellular recruitment, angiogenesis, and cellular proliferation, this total enzymatic shutdown strips local repair cells of the baseline signals required to orchestrate tissue regeneration. Curcumin avoids this indiscriminate pathway paralysis by acting upstream on master transcriptional control switches rather than directly neutralizing isolated enzymes. Its primary therapeutic mechanism centers on the inhibition of Nuclear Factor-kappa B (NF-kB) and Activator Protein-1 (AP-1) signaling networks. Under acute stress or chronic inflammatory loads, the NF-kB protein complex is released from its cytoplasmic inhibitor, IkBa, and translocates directly into the cell nucleus, where it drives the transcription of catabolic cytokines such as interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-a), and interleukin-6 (IL-6). Curcumin blocks the phosphorylation and degradation of IkBa, effectively keeping NF-kB trapped in the cytoplasm. By preventing this nuclear entry, curcumin attenuates the expression of pro-inflammatory cytokines and downstream matrix-degrading enzymes while preserving baseline physiological functions. Furthermore, curcumin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) pathways, which upregulate endogenous cellular antioxidants to neutralize destructive reactive oxygen species (ROS) that induce cell death in injured joints.
The Mechanisms of NSAID-Induced Inhibition in Cartilage and Tendon RepairArticular cartilage and tendons are specialized, bradytrophic connective tissues characterized by relatively low basal metabolic rates and limited endogenous vascular supplies. These physical constraints make their cellular maintenance highly vulnerable to pharmaceutical disruptions. When synthetic compounds impair cell migration, survival, or extracellular matrix secretion, the intrinsic repair capacity of these structures is substantially degraded.Cartilage maintenance depends on chondrocytes, the sole cell type residing within articular joints, which are responsible for generating and maintaining the extracellular matrix of Type II collagen and water-binding proteoglycans such as aggrecan. Because adult articular cartilage lacks a direct vascular network, major defect repair relies heavily on the recruitment and chondrogenic differentiation of subchondral mesenchymal stem cells (MSCs) through endochondral ossification. Experimental evaluations demonstrate that systemic or intra-articular NSAID exposure halts this regenerative differentiation. Both nonselective NSAIDs and selective COX-2 inhibitors interfere with chondrocyte maturation and prevent successful tissue integration following cartilage transplantation or microfracture procedures. At the cellular level, common NSAIDs - including indomethacin, ketorolac, and diclofenac - induce cell cycle arrest in chondrocytes by blocking transition from the resting G0 phase to the proliferative G1. phase, substantially reducing viable cell numbers. Concurrently, NSAIDs downregulate Bone Morphogenetic Protein-2 (BMP-2), an essential anabolic signaling molecule that orchestrates matrix synthesis. Histological analyses in animal models reveal that NSAID administration causes a marked loss of extracellular proteoglycan content and widespread chondrocyte depletion, yielding elevated modified Mankin scores that signify advanced structural degeneration. In layman's terms, proteoglycans serve as water-absorbing structural sponges that grant cartilage its elastic shock absorption. When NSAIDs deplete these molecules, the joint surface dries out, becomes brittle, and rapidly wears down under routine mechanical friction. Tendon healing is similarly susceptible to disruption by NSAIDs. Tendons operate as high-tensile structural cables composed of longitudinally arranged Type I collagen fibers, maintained by specialized fibroblasts termed tenocytes and tenoblasts. Healing after acute rupture or chronic tear progresses through an initial inflammatory phase, followed by a proliferative phase of cell migration, and culminates in a lengthy remodeling phase of collagen alignment. In vitro and in vivo studies establish that NSAIDs directly suppress the migration and proliferative capacity of tenocytes during the critical early healing window. Without an adequate cellular workforce migrating into the wound bed, provisional collagen scaffolding cannot be synthesized effectively. The disruption is particularly pronounced at the enthesis, the specialized fibrocartilaginous junction where soft tendon inserts into rigid bone. Re-establishing this transition zone requires coordinated bone remodeling and chondrogenic differentiation, both of which are hindered by COX inhibition. In animal rotator cuff repair models, early administration of NSAIDs significantly delays collagen fiber organization and impairs mechanical integration at the insertion site, resulting in a measurable decline in load-to-failure strength and overall tendon toughness. Furthermore, while prolonged inflammation contributes to pathological degeneration, the transient synthesis of PGE2 during the initial hours following injury is essential for regulating localized microvascular flow and hyperemic nutrient delivery. By eliminating this early prostanoid pulse, NSAIDs starve the repair zone of oxygen and circulating factors precisely when the cellular metabolic demand is highest. Beyond direct biochemical cytotoxicity, systemic NSAIDs introduce a physical hazard known as analgesic arthropathy. In musculoskeletal biomechanics, pain functions as a protective feedback mechanism, forcing the patient to unload an injured joint or limb to prevent structural overload. By effectively blunting the pain reflex while simultaneously undermining the cellular synthesis of proteoglycans and collagen, NSAIDs create a deceptive state of perceived recovery. Patients prematurely resume unrestricted weight-bearing and strenuous activity, placing substantial, uncompensated mechanical forces onto compromised cartilage surfaces and unhealed tendon fibers. Over time, this recurring mechanical trauma accelerates joint space narrowing, promotes microfractures in the subchondral plate, and hastens functional joint breakdown. Chondroprotective and Tenogenic Mechanisms of CurcuminIn sharp contrast to the suppressive actions of synthetic COX inhibitors, curcumin exhibits a tissue-sparing, pro-regenerative biological profile. Rather than paralyzing cellular metabolism, curcumin modulates the microenvironment by suppressing destructive catabolic enzymes while supporting the baseline anabolic signals required for cartilage and tendon reconstruction.In articular cartilage, curcumin acts as a direct chondroprotective agent by dismantling the catabolic cascade induced by pro-inflammatory cytokines. When joint tissues are exposed to elevated IL-1ß and TNF-a, chondrocytes are provoked to synthesize matrix metalloproteinases - specifically collagenases such as MMP-1, MMP-3, and MMP-13 - along with aggrecanases like ADAMTS5. These enzymes function like enzymatic shears, systematically slicing through structural Type II collagen strands and degrading aggrecan cores. Curcumin suppresses the transcription and secretion of MMP-1, MMP-3, MMP-13, and ADAMTS5 by neutralizing NF-kB and AP-1 activation. Concurrently, it upregulates Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2), an essential transcriptional regulator that represses matrix metalloproteinases at the genomic level. In addition to halting extracellular degradation, curcumin protects chondrocytes from inflammatory apoptosis. Exposure to oxidative stress and inflammatory cytokines typically triggers programmed cell death by activating the intrinsic caspase cascade. Curcumin suppresses this apoptotic pathway by reducing the cleavage of executioner caspase-3, downregulating the pro-apoptotic factor Bax, and elevating anti-apoptotic Bcl-2 expression. Microscopic and histological analyses of osteoarthritic cartilage treated with curcumin consistently show robust Safranin O staining, intact surface regularity, preserved chondrocyte density, and significantly reduced Osteoarthritis Research Society International (OARSI) degradation scores. Within tendon biology, curcumin promotes active tissue regeneration (tenogenesis) rather than inert scar formation. In animal models of tendon rupture and surgical repair, curcumin guides tendon-derived stem and progenitor cells (TSPCs) toward mature tenocyte differentiation. This lineage-specific differentiation is orchestrated primarily through activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and Wnt/ß-catenin signaling cascades. As stem cells commit to the tenogenic pathway, they significantly upregulate crucial structural and phenotypic markers, including epithelial cell adhesion molecule (EpCAM), tenomodulin, and the master tendon transcription factor Scleraxis. Through this guided differentiation, curcumin supports the preferential synthesis and organized deposition of high-tensile Type I collagen fibers, the primary architectural building blocks of healthy tendons. Injured tendons typically fill with disorganized, loose Type III collagen, which forms a structurally inferior, compliant scar. Curcumin supplementation promotes the progressive maturation from primitive Type III collagen to densely packed, parallel Type I collagen fibrils, restoring native tensile strength and mechanical breaking force. A major clinical challenge following tendon surgery is the development of peritendinous adhesions, in which excessive fibrotic scar tissue binds the healing tendon to its synovial sheath, restricting range of motion and joint gliding. Postoperative tendon repair involves a balance between extrinsic healing (in which exterior fibroblasts infiltrate the defect and deposit messy scar tissue) and intrinsic healing (in which tenocytes within the tendon substance reconstruct the matrix). Curcumin suppresses excessive peritendinous inflammation and extrinsic fibrosis while accelerating intrinsic tenocyte repair. Biomechanical testing confirms that local or systemic curcumin administration yields lower adhesion scores, increased gliding distances, and superior functional mobility without sacrificing structural load-bearing capacity. Comparative Clinical Efficacy and Systemic Safety ProfilesTranslating cellular findings into clinical practice requires weighing therapeutic outcomes against systemic safety profiles. While synthetic NSAIDs deliver potent, rapid analgesia during acute musculoskeletal pain events, their chronic administration is constrained by systemic toxicities across multiple organ systems.In randomized, active-controlled clinical trials of knee osteoarthritis, optimized curcumin preparations have demonstrated clinical pain reduction and functional recovery comparable to standard therapeutic doses of NSAIDs. In a randomized, open-label parallel-arm study evaluating 139 patients with symptomatic knee osteoarthritis, subjects received either 500 mg of a bio-enhanced curcumin extract three times daily or 50 mg of diclofenac sodium twice daily for 28 consecutive days. Patients treated with curcumin demonstrated comparable improvements in pain intensity on the Visual Analogue Scale (VAS) and functional scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) at days 14 and 28, showing no statistically significant difference in therapeutic efficacy compared to diclofenac. However, the systemic tolerability profiles between the treatments diverged markedly. Overall adverse events occurred in only 13% of the curcumin group compared to 38% of the diclofenac cohort. In the diclofenac arm, 28% of patients developed dyspeptic symptoms severe enough to require concurrent treatment with H2-receptor antagonists or proton pump inhibitors to prevent mucosal ulceration, whereas no patients in the curcumin cohort required gastroprotective intervention. Furthermore, the curcumin cohort experienced a significant reduction in flatulence and digestive discomfort, demonstrating beneficial gastric and intestinal cytoprotective effects. These safety observations are consistent across broader systematic reviews and meta-analyses. Nonsteroidal anti-inflammatory agents inherently compromise gastrointestinal integrity by systematically depleting cytoprotective prostaglandins, leaving the gastric epithelium vulnerable to acid erosion and hemorrhage. In addition, systemic inhibition of renal and vascular COX enzymes by NSAIDs reduces renal perfusion and disrupts the balance between prostacyclin and thromboxane, elevating the risk of fluid retention, hypertension, and adverse cardiovascular thrombotic events. Curcumin does not suppress these physiological prostanoid pathways, making it free from ulcerogenic, nephrotoxic, and cardiotoxic properties at therapeutic dosages.
A longstanding limitation of standard curcumin supplementation in clinical settings has been its low oral bioavailability. Native curcuminoids are highly lipophilic, poorly soluble in aqueous gastric fluids, and subject to rapid hepatic and intestinal phase II metabolism into inactive glucuronides and sulfates, leading to swift biliary and fecal excretion. Consequently, raw culinary turmeric powders struggle to achieve the therapeutic systemic circulating concentrations required to reach poorly vascularized joint and tendon compartments. Modern pharmacognosy has addressed this pharmacodynamic hurdle through advanced delivery formulations. Modern strategies - such as co-administration with the natural alkaloid piperine (which inhibits hepatic glucuronidation), micellar dispersions, phytosomal phospholipid complexes, and bio-enhanced submicron dispersions - elevate systemic blood bioavailability by ten- to thirty-fold compared to unformulated extracts. These modern delivery platforms ensure that therapeutic concentrations reach synovial fluid, subchondral bone, and fibrous tendon sheaths without requiring excessive oral dosing. Conclusions and Translational Clinical ImplicationsThe biological and clinical evidence reveals distinct physiological paths for NSAIDs and curcumin in orthopedic recovery. While NSAIDs remain powerful tools for the brief alleviation of acute, unmanageable pain, their ongoing administration during active tissue healing presents substantial biological compromises. Tendons and cartilage require a controlled, transient inflammatory cascade to signal cell recruitment, stimulate stem cell differentiation, and direct extracellular matrix synthesis. By completely shutting down cyclooxygenase enzymes and depleting local prostaglandins, NSAIDs disrupt this regenerative cascade. The resulting cellular consequences - including chondrocyte cell cycle arrest, proteoglycan loss, suppression of tenocyte migration, and weakened collagen tensile strength at the tendon-to-bone interface - demonstrate that pain relief from NSAIDs frequently comes at the cost of the structural integrity of healing connective tissues.In contrast, curcumin provides a tissue-preserving alternative that decouples pain and inflammation control from cellular suppression. Operating upstream at the level of NF-kB and AP-1 transcriptional activation, curcumin attenuates the expression of pro-inflammatory cytokines while leaving the physiological baseline of cellular metabolism intact. In cartilage, it actively represses the matrix-degrading enzymes MMP-1, MMP-3, MMP-13, and ADAMTS5, maintains water-binding proteoglycan content, and protects chondrocytes from inflammatory apoptosis. In damaged tendons, curcumin stimulates tenogenic differentiation of local stem cells via PI3K/Akt signaling, supports the proper maturation of dense Type I collagen fibers, and prevents restrictive peritendinous scar adhesions, preserving both joint mobility and mechanical breaking strength. From a translational perspective, these findings indicate that clinical protocols should reconsider relying on continuous NSAIDs as the default intervention for connective tissue injuries, post-surgical recovery, and chronic degenerative conditions. Where synthetic NSAIDs are deemed necessary, their use should be confined to short-term acute flare-ups to avoid interrupting early tissue remodeling. For long-term joint preservation, ongoing tendinopathy rehabilitation, and chronic osteoarthritis management, optimized bio-enhanced curcumin formulations deliver pain relief and functional restoration comparable to conventional pharmaceuticals, all while preserving the biological processes required for lasting musculoskeletal repair. References: NSAID therapy effects on healing of bone, tendon, and the enthesis The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Conservative management of symptomatic knee osteoarthritis - PMC Positives and negatives of nonsteroidal anti-inflammatory drugs in (PDF) Conservative management of symptomatic knee osteoarthritis Non-steroidal anti-inflammatory drugs influence cartilage healing Is Curcumine Useful in the Treatment and Prevention of ... - PMC - NIH Efficacy and mechanisms of curcumin in the treatment of osteoarthritis Biological actions of curcumin on articular chondrocytes - PubMed Curcumin slows osteoarthritis progression and relieves ... - PMC - NIH Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Anti-inflammatory management for tendon injuries - friends or foes? The mechanistic role of curcumin on matrix metalloproteinases in Therapeutic effects of turmeric or curcumin extract on pain and Curcumin inhibits chondrocyte apoptosis and inflammation in ... - PMC Analysis of the mechanism of curcumin against osteoarthritis using Synergistic enhancement of tendon-to-bone healing via anti ... - PMC A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis A randomized, pilot study to assess the efficacy and safety ... - PubMed Effectiveness of curcuminoids in the treatment of knee osteoarthritis THE EFFECTS OF TRADITIONAL STRENGTHENING EXERCISES Putting Some Muscle into Osteoarthritis | Annals of Internal Medicine Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Calebin A, a Compound of Turmeric, Down-Regulates Inflammation The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to Chiropractor in Toronto, ON, Canada :: Head and Neck Pain Investigation of the association of long-term NSAID use with ... - PMC Curcumin Improves Functional Recovery of Ruptured Tendon by Chemically modified curcumin (CMC2.24) alleviates osteoarthritis Curcumin improves age-related and surgically induced osteoarthritis (PDF) Curcumin Improves Functional Recovery of Ruptured Tendon Investigation of the effects of umbilical cord-derived mesenchymal Effect of curcumin-loaded polycaprolactone scaffold on Achilles Controlled release of curcumin from curcumin-loaded nanomicelles Efficacy and safety of combination of curcuminoid complex ... - PMC The efficacy of Curcuma Longa L. extract as an adjuvant therapy in
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6653) The Ultimate Guide to Cellular Longevity: NAD+, Methylation, and Senolytics 
Date:
September 10, 2026 10:57 AM
Introduction: Understanding Cellular Aging and Energy DeclineBiological aging represents a progressive decline in cellular maintenance, structural repair, and energy generation. Over decades, tissues experience an attrition of functional reserves, compromised stress resilience, and persistent low-grade systemic inflammation. At the cellular scale, biological degeneration is driven by a failure to generate bioenergetic fuel, repair genetic code, and clear metabolic waste.Cellular aging is characterized by interconnected biological disruptions known as the hallmarks of aging. These encompass genomic instability, epigenetic alterations, mitochondrial decay, loss of proteostasis, and cellular senescence. Rather than operating as isolated occurrences, these phenomena establish a self-reinforcing degenerative cycle: declining cellular power generation impairs enzymatic genetic repair, promoting the accumulation of damaged cells that enter irreversible growth arrest and poison surrounding healthy tissues. Mitigating cellular aging requires examining how microscopic bioenergetic pathways deteriorate and evaluating how targeted nutritional and biochemical interventions can restore cellular homeostasis. The Role of Mitochondria and ATP ProductionEvery biological function - from muscular contraction to continuous DNA replication - depends on adenosine triphosphate (ATP), the primary biochemical energy currency of living systems. Cells produce the vast majority of this energy within mitochondria through oxidative phosphorylation. Within these specialized organelles, metabolic intermediates derived from dietary carbohydrates and lipids donate high-energy electrons to the electron transport chain. The flow of these electrons across protein complexes establishes an electrochemical proton gradient across the inner mitochondrial membrane, driving ATP synthase to manufacture ATP.A youthful cell functions like an efficient municipal power grid, dynamically matching energetic demands with immediate ATP output. However, as biological aging progresses, mitochondrial efficiency declines. The electron transport chain becomes structurally leaky, inadvertently shedding electrons that react with ambient molecular oxygen to produce reactive oxygen species (ROS). While regulated levels of ROS participate in vital intracellular signaling, chronic excess induces widespread oxidative stress. Mitochondria are exceptionally vulnerable to this oxidative burden because they carry their own circular genetic material, known as mitochondrial DNA (mtDNA). Unlike nuclear DNA, mtDNA lacks the protective shielding of histone proteins and possesses rudimentary repair systems. As a result, mtDNA sustains cumulative oxidative damage, encoding increasingly defective electron transport chain proteins. This dynamic generates a bioenergetic deficit: degraded mitochondria synthesize progressively less ATP while emitting greater volumes of damaging free radicals. Deprived of optimal ATP reserves, cells lack the energy necessary to drive vital enzymatic repair cascades, accelerating structural degeneration and functional exhaustion. How Cellular Senescence Accelerates the Aging ProcessWhen healthy cells confront critical physiological damage - such as severe telomere attrition, persistent DNA double-strand breaks, or oxidative stress - they activate protective cell cycle arrest pathways governed primarily by the p53/p21^CIP1 and p16^INK4a/Rb molecular checkpoints. This defensive shutdown, termed cellular senescence, permanently prevents the replication of potentially premalignant or mutated cells.Senescent cells, colloquially known as "zombie cells," enter a state of permanent growth arrest while actively resisting programmed cell death (apoptosis). Over time, these cells accumulate within adipose depots, skeletal muscle, the vascular endothelium, and major organs, largely because immune surveillance and clearance pathways simultaneously lose functional efficiency. The systemic danger of senescent cells stems from their secretome. Rather than remaining biologically inert, senescent cells develop a hyperactive secretory state termed the Senescence-Associated Secretory Phenotype (SASP). The SASP is a destructive mixture of pro-inflammatory cytokines, chemokines, extracellular matrix-degrading matrix metalloproteinases (MMPs), and reactive oxygen species. Through this toxic secretome, even a small burden of senescent cells can impair whole-tissue architecture. SASP factors degrade surrounding structural proteins, induce insulin resistance in neighboring metabolic cells, and biochemically force adjacent healthy cells into secondary senescence. This persistent paracrine signaling fuels chronic, sterile, low-grade systemic inflammation, termed "inflammaging," which accelerates systemic tissue degeneration and elevates susceptibility to degenerative age-related pathologies. Nicotinamide Riboside (NR) and the NAD+ Salvage PathwayThe Biochemistry of NAD+ Depletion Over TimeNicotinamide adenine dinucleotide (NAD+) is an indispensable coenzyme present in every living cell. NAD+ fulfills a dual biological mandate: it serves as a central redox cofactor that shuttles electrons between cellular metabolic reactions, and it functions as an obligatory consumable substrate for regulatory enzymes that preserve cellular viability. In its redox capacity, NAD+ accepts electrons to form NADH during glycolysis, the tricarboxylic acid (TCA) cycle, and fatty acid beta-oxidation, subsequently donating those electrons to Complex I of the respiratory chain to power ATP synthesis.
The primary enzymatic driver of age-related NAD+ destruction is CD38, a membrane-bound glycohydrolase expressed on immune cells that is upregulated in response to chronic SASP exposure. Concurrently, lifelong genotoxic damage causes persistent activation of Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that cleaves the glycosidic bonds of NAD+ to assemble branched poly(ADP-ribose) chains at DNA lesion sites. Because PARP-1 consumes NAD+ without directly recycling the molecule, chronic DNA damage depletes intracellular NAD+ pools, impairing bioenergetics and limiting sirtuin activity. How NR Efficiently Boosts Cellular NAD+ LevelsThe mammalian body maintains its NAD+ supply through three distinct biosynthetic routes: the de novo pathway from dietary L-tryptophan, the Preiss-Handler pathway from nicotinic acid (niacin), and the NAD+ Salvage Pathway. The de novo pathway requires substantial energy expenditure, consuming roughly sixty milligrams of dietary tryptophan to yield a single milligram of NAD+. The Preiss-Handler pathway, while effective, can induce cutaneous prostaglandin-mediated flushing at therapeutic intakes. Consequently, the salvage pathway serves as the primary mechanism for maintaining intracellular NAD+ pools.The salvage pathway recycles the breakdown product nicotinamide (NAM), which is released whenever NAD+-consuming enzymes execute their functions. Under normal conditions, cells convert free nicotinamide into nicotinamide mononucleotide (NMN) via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), after which NMN adenylyltransferases (NMNAT1–3) complete the conversion into NAD+. However, NAMPT expression declines with advancing age, chronic inflammation, and metabolic stress, limiting the recycling capacity of the cell. Nicotinamide Riboside (NR) is a naturally occurring pyridine nucleoside that bypasses this enzymatic bottleneck. Upon cellular entry via equilibrative nucleoside transporters, NR is directly phosphorylated into NMN by nicotinamide riboside kinases (NRK1 and NRK2) using a single molecule of ATP. Because the NRK pathway remains intact and robust across the lifespan, NR provides an efficient alternative entry point into the NAD+ salvage cascade. Clinical evaluations in humans confirm the safety, bioavailability, and pharmacokinetics of oral NR supplementation. Randomized, double-blind, placebo-controlled trials reveal that oral NR chloride produces dose-dependent increases in steady-state whole blood NAD+ concentrations. Dosing regimens of 100 mg, 300 mg, and 1,000 mg daily elevate blood NAD+ levels by approximately 22%, 51%, and up to 142%, respectively, within two weeks of administration, maintaining these elevations throughout continuous use. High-resolution metabolomic analyses also demonstrate parallel elevations in nicotinic acid adenine dinucleotide (NAAD), establishing it as a reliable biomarker of active intracellular NAD+ synthesis without hepatic or systemic toxicity. Sirtuin Activation and DNA Repair MechanismsReplenishing intracellular NAD+ supports functions beyond mitochondrial ATP generation. NAD+ functions as an obligatory cofactor for sirtuins (SIRT1 through SIRT7), a family of class III histone and non-histone protein deacetylases that regulate stress resilience, metabolic homeostasis, and cell survival. Sirtuins couple the removal of acetyl groups from target lysine residues to the stoichiometric cleavage of NAD+, producing nicotinamide and O-acetyl-ADP-ribose. In states of NAD+ deficiency, sirtuin enzymes remain inactive regardless of cellular demand.In the nucleus, SIRT1 coordinates defense against cellular decline. When activated by restored NAD+ levels, SIRT1 deacetylates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a), the master transcriptional coactivator of mitochondrial biogenesis. This deacetylation stimulates mitochondrial replication and assembly, expanding functional respiratory capacity. Concurrently, SIRT1 deacetylates the p65 subunit of nuclear factor-kappa B (NF-kB), suppressing the transcription of pro-inflammatory cytokines. In the mitochondria, SIRT3 utilizes NAD+ to deacetylate metabolic enzymes and superoxide dismutase 2 (SOD2), enhancing the organelle's capacity to neutralize reactive oxygen species. At the same time, cellular NAD+ levels directly regulate genomic integrity through PARP-1. When genotoxic stress or oxidative damage induces single- or double-strand DNA breaks, PARP-1 binds to the damaged termini using its zinc-finger domains. Bound PARP-1 hydrolyzes NAD+ to synthesize extensive, negatively charged poly(ADP-ribose) polymers on itself and adjacent histones. This modification relaxes chromatin architecture and establishes an electrostatic scaffold that recruits base excision repair and homologous recombination complexes. Recent discoveries demonstrate close crosstalk between sirtuins and PARP-1 during DNA repair. PARP-1 recruits SIRT1 to double-strand breaks, where SIRT1 deacetylates the chromatin-remodeling ATPase BRG1 to displace nucleosomes and facilitate homologous recombination. However, because PARP-1 and SIRT1 draw from the same intracellular NAD+ pool, severe NAD+ depletion forces a biological compromise: PARP-1 consumes the scarce remaining cofactor to address DNA damage, leaving sirtuins deactivated. Restoring NAD+ via NR prevents this deficit, enabling concurrent genomic repair and sirtuin-mediated metabolic defense. Quercetin: A Powerful Senolytic and mTOR RegulatorClearing Senescent "Zombie" Cells from TissuesThe accumulation of senescent cells has driven interest in senolytics: molecules that selectively eliminate senescent cells while sparing healthy, non-senescent populations. Senolytic agents exploit a specific vulnerability in senescent cells. Because senescent cells produce cytotoxic, pro-inflammatory SASP factors that would normally induce their own death, they become dependent on upregulated Senescent Cell Anti-Apoptotic Pathways (SCAPs) to survive. The SCAP network involves anti-apoptotic proteins (such as BCL-2 and BCL-xL), the PI3K/Akt kinase cascade, and cyclin-dependent kinase inhibitors.Quercetin is a polyphenolic flavonoid found in capers, red onions, apples, and the flower buds of Sophora japonica. Beyond its classical antioxidant properties, quercetin functions as a senolytic compound that exerts multi-target inhibitory effects across the SCAP network. By inhibiting the upstream PI3K/Akt survival axis and downregulating anti-apoptotic defenses, quercetin disrupts the signaling that protects senescent cells from intrinsic apoptosis. Deprived of these survival signals, senescent cells undergo programmed cell death. Preclinical studies demonstrate that senolytic protocols utilizing quercetin - often combined with the tyrosine kinase inhibitor dasatinib - reduce senescent cell burden across multiple tissues. This targeted clearance lowers circulating SASP factors, attenuates tissue fibrosis, restores endothelial reactivity, and improves functional health span. By removing senescent cells, quercetin mitigates the primary driver of chronic, low-grade inflammaging. Modulating the mTOR Pathway for Optimal AutophagyThe mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that coordinates cellular metabolism by balancing anabolic growth with catabolic recycling. Operating within two multiprotein complexes - mTORC1 and mTORC2 - the mTOR pathway integrates signals from amino acids, growth factors, and intracellular energy levels. In nutrient-rich environments, mTORC1 promotes protein synthesis, lipogenesis, and cellular growth, while suppressing catabolic breakdown. Conversely, nutrient scarcity downregulates mTORC1, activating autophagy.Autophagy is an intracellular degradation system that packages damaged organelles, misfolded protein aggregates, and biological debris into double-membraned autophagosomes for lysosomal degradation and recycling. A specialized branch of this pathway, mitophagy, selectively targets and clears damaged mitochondria. In modern metabolic conditions characterized by continuous caloric intake, mTORC1 can remain persistently active. This persistent signaling suppresses autophagy, causing damaged organelles and toxic aggregates to accumulate within tissues. Quercetin functions as a natural modulator of mTOR signaling. By inhibiting upstream PI3K/Akt signaling and activating intracellular energy sensors, quercetin attenuates overactive mTORC1, mimicking the metabolic effects of caloric restriction. This down-regulation relieves inhibition on the ULK1 autophagy initiation complex, stimulating both general autophagy and mitophagy. As autophagy proceeds, cells clear protein aggregates and eliminate damaged mitochondria, supporting cellular longevity and proteostasis. Enhancing Absorption: Phytosomes and Dietary FatsDespite the biological activities of quercetin identified in experimental models, its clinical translation has historically been limited by poor oral bioavailability. Raw quercetin aglycone is a crystalline, hydrophobic polyphenol with poor solubility in water and gastrointestinal fluids. When ingested in unformulated powder forms, quercetin molecules aggregate in the gut lumen, resisting dissolution and passive absorption. Consequently, the vast majority of an unformulated dose passes into the colon unabsorbed, where it undergoes microbial degradation without reaching meaningful systemic concentrations.To address these pharmacokinetic limitations, advanced delivery systems such as phytosomes were engineered. A phytosome is a 100% food-grade molecular complex where individual polyphenolic molecules are bound to dietary phospholipids, typically sunflower-derived phosphatidylcholine. Unlike a classical liposome - which encapsulates water-soluble compounds inside an aqueous core enclosed by a lipid bilayer - a phytosome forms an amphiphilic complex at the molecular level. The polar head of the phosphatidylcholine molecule forms hydrogen bonds with the hydroxyl groups of the quercetin molecule, while its lipophilic fatty acid tails extend outward. This structural arrangement shields the polar regions of the flavonoid, creating a lipid-compatible complex that integrates smoothly into the intestinal mucosa.
The Importance of Methylation in Healthy AgingVitamin B-Complex and Choline as Essential Methyl DonorsMethylation is an essential biochemical process occurring billions of times each second across all human tissues. It involves the transfer of a single-carbon unit - a methyl group consisting of one carbon atom bound to three hydrogen atoms - (CH3) - from a donor molecule to diverse recipients, including DNA, RNA, structural proteins, neurotransmitters, and membrane phospholipids. This transfer of one-carbon units is coordinated by the methionine-homocysteine cycle, which sustains genetic stability, detoxification pathways, and cellular repair.At the center of this pathway sits S-adenosylmethionine (SAM), the universal methyl donor in human biology. When a methyltransferase enzyme transfers a methyl group from SAM to an acceptor molecule, SAM is converted into S-adenosylhomocysteine (SAH). SAH functions as a potent competitive inhibitor of intracellular methyltransferases. To maintain functional methylation, SAH is rapidly hydrolyzed into homocysteine, a sulfur-containing amino acid that must be remethylated or cleared through transsulfuration. Homocysteine clearance proceeds through two distinct remethylation pathways. The primary route operates across most tissues via the enzyme methionine synthase, which requires vitamin B12 in its active methylcobalamin form. Methionine synthase transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF, the active form of folate) to homocysteine, regenerating methionine. The ongoing production of 5-MTHF depends on the enzyme methylenetetrahydrofolate reductase (MTHFR), which utilizes riboflavin (vitamin B2) as a cofactor. Alternatively, excess homocysteine can be routed into the transsulfuration pathway by vitamin B6 (as pyridoxal-5'-phosphate) to synthesize cystathionine, cysteine, and ultimately the antioxidant glutathione. A secondary remethylation pathway, active predominantly in hepatic and renal tissues, bypasses folate entirely. In this route, dietary choline is oxidized to betaine (trimethylglycine or TMG). The enzyme betaine-homocysteine S-methyltransferase (BHMT) then transfers a methyl group from betaine directly to homocysteine, yielding methionine and dimethylglycine. When dietary intake of active B-vitamins or choline is insufficient, or when genetic variations like MTHFR polymorphisms reduce pathway flux, the methylation cycle slows. Homocysteine accumulates in circulation, promoting vascular and neurological inflammation, while SAM reserves decline, restricting cellular methylation capacity. Understanding DNA Methylation and Epigenetic HealthEvery somatic cell in an organism carries an identical genetic code. Cellular differentiation and tissue-specific functions are governed by the epigenome: a regulatory layer of chemical modifications that dictates gene expression without altering underlying DNA sequences. DNA methylation represents the primary and most stable epigenetic modification. In this process, DNA methyltransferase (DNMT) enzymes utilize methyl groups donated by SAM to add a methyl tag to cytosine bases adjacent to guanine residues, forming 5-methylcytosine within CpG dinucleotide sites.Under physiological conditions, DNA methylation maintains genomic stability and coordinates transcription. Methylation of promoter regions condenses chromatin, repressing transposable elements and silencing genes inappropriate for a given cell type. Conversely, hypomethylated promoters maintain an open chromatin state, allowing transcription factors to bind and initiate gene expression. During biological aging, this epigenetic landscape undergoes progressive dysregulation, a phenomenon termed "epigenetic drift". Aging cells experience global hypomethylation alongside focal hypermethylation of specific gene promoters. Global loss of methyl tags destabilizes the genome, activating retrotransposons and pro-inflammatory pathways. Simultaneously, hypermethylation at targeted promoter sites silences critical tumor suppressor genes and DNA repair complexes. This systematic change in DNA methylation patterns is consistent across populations, allowing researchers to develop molecular "epigenetic clocks". Algorithms such as the Horvath clock, PhenoAge, and GrimAge quantify biological age by profiling the methylation status of specific CpG sites across the genome. These clocks assess whether individuals are aging faster or slower than their chronological years. Ensuring a steady supply of methyl donors and preventing unnecessary SAM depletion supports DNMT activity, maintaining epigenetic patterns and genomic stability. How the Methylation Cycle Impacts Energy and Cognitive FocusBeyond long-term epigenetic regulation, the methylation cycle directly modulates immediate biochemical processes that govern daily energy, neurotransmission, and cognitive focus. Compromised methylation capacity frequently manifests as cognitive slowing, executive fatigue, and reduced physical stamina.A major consumer of methyl reserves is the endogenous synthesis of creatine. Approximately 40% of all SAM-derived methyl groups in the human body are utilized by guanidinoacetate N-methyltransferase (GAMT) in the liver to synthesize creatine. Creatine then translocates to the brain and skeletal muscle, where it is phosphorylated into phosphocreatine. Phosphocreatine functions as a rapid energy buffer, donating a high-energy phosphate group to regenerate ADP into ATP in milliseconds during demanding physical or cognitive tasks. When methyl donor availability falls, endogenous creatine synthesis drops, depleting phosphocreatine reserves and increasing susceptibility to neuromuscular and cognitive fatigue. Methylation is equally central to central nervous system architecture. SAM provides methyl groups to convert phosphatidylethanolamine into phosphatidylcholine, the predominant phospholipid comprising neuronal cell membranes and the myelin sheaths that insulate axons. Intact myelin preserves rapid action potential conduction throughout the nervous system. Furthermore, free choline derived from this pathway is the direct precursor to acetylcholine, the neurotransmitter required for attention, working memory, and learning. The methylation cycle also governs monoamine neurotransmitter metabolism. SAM is required for the synthesis of adrenaline (epinephrine) from noradrenaline, while catechol-O-methyltransferase (COMT) relies on SAM to degrade dopamine and norepinephrine within the prefrontal cortex. Sluggish methylation disrupts this balance, contributing to cognitive fatigue, mood variability, and impaired mental performance. Building a Comprehensive Longevity ProtocolSynergizing NR, Quercetin, and Methylated B-VitaminsLongevity supplementation often falters when single molecules are administered in isolation, ignoring interconnected metabolic pathways. Designing an effective cellular longevity protocol requires combining complementary mechanisms that reinforce one another while preventing secondary metabolic deficits. The combination of Nicotinamide Riboside, Quercetin Phytosome, and Methylated B-Vitamins illustrates this multi-target synergy.This synergy is grounded in the direct biochemical intersection between the NAD+ salvage pathway and the methylation cycle. When high-dose NR is supplemented to boost systemic NAD+, sirtuins and PARP enzymes consume the newly synthesized cofactor, generating substantial quantities of free nicotinamide (NAM). This intracellular nicotinamide faces two primary metabolic fates: it can be recycled back into NAD+ through the NAMPT-dependent salvage loop, or it can be cleared via methylation. When the influx of nicotinamide exceeds salvage recycling capacity, the excess is cleared to avoid feedback inhibition of sirtuin enzymes. To accomplish this, the enzyme nicotinamide N-methyltransferase (NNMT) transfers a methyl group from SAM directly onto nicotinamide, forming 1-methylnicotinamide (1-MNA/MNAM), which is subsequently excreted in urine. Prolonged, high-dose precursor administration without nutritional methyl support can elevate NNMT flux, depleting intracellular SAM reserves. As methyl groups are consumed clearing nicotinamide, the cellular SAM-to-SAH ratio falls, which can elevate circulating homocysteine and reduce methyl availability for DNA methylation and neurotransmitter synthesis. Co-administering a fully methylated B-complex alongside choline or betaine addresses this potential bottleneck. Providing active methyl donors (such as 5-MTHF, methylcobalamin, and betaine) maintains the one-carbon donor pool. Even during increased NNMT activity, SAM pools remain stable, protecting DNA methylation fidelity and maintaining homocysteine within safe parameters. Quercetin reinforces this protocol through complementary mechanisms. By clearing senescent cells and reducing SASP-mediated inflammation, quercetin downregulates CD38, the primary enzyme responsible for age-related NAD+ degradation. Suppressing CD38 prevents unnecessary breakdown of newly synthesized NAD+, enhancing the efficiency of NR supplementation. Furthermore, while NR provides the NAD+ necessary to activate SIRT1-driven mitochondrial biogenesis, quercetin concurrently modulates mTORC1 to stimulate autophagy. This coordinated action ensures that newly generated mitochondria operate in an environment cleared of proteotoxic cellular debris. The Crucial Role of Magnesium Glycinate and Zinc in Cellular FunctionLongevity protocols require essential mineral cofactors to function efficiently. Without adequate divalent minerals acting as enzymatic cofactors and structural stabilizers, metabolic longevity pathways cannot operate at full capacity. Among these, magnesium and zinc are required for cellular repair, genomic stability, and energy production.Magnesium serves as an obligatory cofactor in over 300 enzymatic reactions, primarily through its interaction with ATP. In biological systems, ATP exists predominantly as a chelate with a divalent magnesium ion, forming biologically active Mg2+ -ATP. Every enzymatic reaction that synthesizes, transfers, or consumes cellular energy - including the enzymes of the NAD+ salvage pathway (NRK and NMNAT) and DNA polymerases - strictly requires Mg2+ -ATP as its substrate. Magnesium deficiency impairs these phosphorylation reactions, reducing the cellular utilization of NAD+ precursors. Additionally, magnesium is an essential cofactor for the enzymes that activate dietary B-vitamins into their active forms. Supplying magnesium as magnesium glycinate provides high gastrointestinal bioavailability, minimal laxative effect, and yields glycine to support inhibitory neurotransmission and restful sleep. Zinc serves as a vital structural component for more than 3,000 human transcription factors and enzymatic proteins. Its most prominent structural role in longevity occurs within zinc-finger motifs. These are specialized protein conformations stabilized by a zinc ion coordinated to cysteine and histidine residues. The DNA damage sensor PARP-1 utilizes three zinc-finger domains to identify, track, and physically bind to single- and double-strand DNA breaks. Without adequate intracellular zinc, PARP-1 cannot properly assemble or dock onto damaged chromosomes, impairing DNA repair and increasing genomic instability. Zinc is also an obligatory structural component of copper/zinc superoxide dismutase (Cu/Zn-SOD or SOD1), the primary cytosolic antioxidant enzyme that dismutates superoxide radicals into hydrogen peroxide, protecting mitochondrial membranes and nuclear DNA from premature senescence. Integrating Prebiotics (like Acacia and Inulin) for Gut-Derived Longevity MarkersA comprehensive cellular longevity framework must extend beyond somatic tissues to encompass the gut microbiome. The intestinal microbiome functions as a central regulator of systemic inflammatory tone, immune development, and metabolic signaling. Age-associated dysbiosis - characterized by the loss of beneficial commensals and an overgrowth of pathobionts - frequently leads to breakdown of the intestinal barrier.The gut epithelium consists of a single-cell monolayer sealed by tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and claudins. When this physical barrier is disrupted by poor dietary fiber intake or dysbiosis, gut permeability increases. This allows lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, to enter the portal and systemic circulation. The resulting "metabolic endotoxemia" activates Toll-like receptor 4 (TLR4) on immune cells, inducing NF-kB and systemic pro-inflammatory cytokine production. This persistent gut-derived inflammation exacerbates the SASP, accelerates tissue senescence, upregulates CD38, and drains systemic NAD+ reserves.
These short-chain fatty acids, particularly butyrate, exert direct protective effects on systemic longevity. Butyrate provides the primary metabolic fuel for colonic epithelial cells, supplying more than 70% of their baseline energy needs and supporting mitochondrial function within colonocytes. Furthermore, SCFAs upregulate the expression of epithelial tight junction proteins (ZO-1, occludin, and claudin-1), restoring intestinal barrier integrity and preventing the translocation of inflammatory LPS into systemic circulation. Systemically absorbed butyrate also functions as an endogenous histone deacetylase (HDAC) inhibitor, suppressing pro-inflammatory gene expression and supporting regulatory T cell (T_reg) development. Reducing metabolic endotoxemia dampens systemic inflammation, protecting vascular function and preventing premature NAD+ depletion. Conclusion: The Integrated Cellular Longevity MatrixCellular longevity is achieved not by addressing isolated biomarkers in isolation, but by systematically supporting interconnected biological pathways. As bioenergetic capacity declines, cellular senescence accelerates, epigenetic patterns degrade, and gut barrier integrity weakens. A comprehensive approach addresses these biological vulnerabilities simultaneously.
Quercetin Phytosome clears senescent cells and modulates mTORC1, stimulating autophagy while dampening the inflammatory SASP cascade that accelerates CD38-mediated NAD+ destruction. Methylated B-vitamins, active folate, and choline replenish SAM reserves, balancing the methyl requirements of NNMT-mediated nicotinamide clearance, preserving epigenetic DNA methylation, and maintaining neurotransmitter production. Magnesium glycinate and zinc provide the structural and catalytic foundation required for ATP utilization, B-vitamin activation, and PARP-1 zinc-finger DNA repair docking. Finally, prebiotic fibers generate short-chain fatty acids like butyrate, reinforcing the intestinal barrier and preventing metabolic endotoxemia from fueling systemic inflammation. By coordinating energy replenishment, cellular waste clearance, epigenetic maintenance, and the suppression of systemic inflammation, this unified approach directly addresses the underlying drivers of cellular aging to support long-term physiological vitality.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6650) Unlocking Your Cellular Vitality: Understanding the Role of Mitochondria in Energy and Aging
Date:
September 09, 2026 05:22 PM
Introduction: Understanding Cellular Aging and Energy DeclineHave you ever wondered why you could bounce back from an all-nighter or an intense workout in your twenties, but in your forties or fifties, the same physical effort leaves you feeling drained for days?Most people think aging is something that happens strictly on the outside - fine lines around the eyes, stiff joints, or gray hairs. In reality, aging begins at a microscopic scale inside your cells, the microscopic building blocks that make up every tissue, muscle, and organ in your body. Every single day, your body relies on roughly 30 trillion cells working in unison. When your cells are young and resilient, they operate like a well-oiled machine: they repair minor damage instantly, clear away waste, and produce abundant energy. But over time, two fundamental biological shifts take place:
The Role of Mitochondria and ATP ProductionTo understand where your daily energy comes from, you have to look inside your cells at tiny structures called mitochondria.Often called the "powerhouses" of the cell, mitochondria function like miniature power stations. A single cell can house hundreds or even thousands of them, especially energy-hungry cells like those in your heart, brain, and skeletal muscles. The Body’s Energy Currency: What is ATP?Your body cannot directly use a sandwich or a cup of coffee to power muscle contractions or brain signals. Instead, your mitochondria take the nutrients from your food and combine them with the oxygen you breathe to manufacture a chemical molecule called adenosine triphosphate (ATP).Think of ATP as your body’s universal energy currency:
Why Cellular Energy Production Declines with AgeWhen you are young, your mitochondria are abundant, pristine, and remarkably efficient. However, the very process of creating energy comes with an unavoidable side effect: oxidative stress.Much like an engine produces exhaust fumes while burning fuel, mitochondria produce reactive byproducts known as free radicals (reactive oxygen species). Over decades, these "exhaust fumes" slowly damage the inner machinery of the mitochondria:
How Cellular Senescence Accelerates the Aging ProcessIf mitochondrial decline is a problem of power shortage, cellular senescence is a problem of biological clutter and pollution.In a healthy body, normal cells follow a strict lifecycle: they divide, perform their jobs, and when they incur significant damage or reach the end of their useful lifespan, they undergo a tidy self-destruction process called apoptosis (programmed cell death). Your immune system then clears away the debris, making room for fresh, vibrant cells. Cellular senescence happens when this cleanup process fails. The "Zombie Cell" PhenomenonWhen a cell experiences extreme stress - such as shortened telomeres (the protective caps on chromosomes), severe DNA breaks, or severe mitochondrial dysfunction - it reaches a biological crossroads. To prevent the damaged cell from dividing uncontrollably (which could lead to tumors), the body puts the brakes on.The cell enters a permanent state of dormancy:
Why Zombie Cells Are So Damaging: The Bad Apple EffectHaving a few retired cells hanging around might not sound catastrophic, but senescent cells do not sit quietly. Instead, they secrete a toxic chemical cocktail known as the Senescence-Associated Secretory Phenotype (SASP).This cocktail is packed with pro-inflammatory cytokines, chemokines, and tissue-degrading enzymes. Picture one spoiled apple sitting in a fruit basket: the ethylene gas it emits quickly causes the healthy apples surrounding it to rot. In the same way, the toxic secretions from zombie cells:
The Vicious Cycle of Cellular AgingMitochondrial decay and cellular senescence are not isolated events; they feed directly into one another:
What This Means for Everyday HealthThe good news from modern longevity science is that cellular decline is not entirely out of our hands. While aging is natural, the rate at which our cellular engines degrade can be influenced by daily habits:
Summary: Aging is fundamentally a microscopic process occurring inside the body's trillions of cells, which naturally become less resilient over time. Central to this decline are the mitochondria, the tiny structures that function as the cell's "power plants" to produce adenosine triphosphate (ATP), the universal chemical currency for everyday energy. While young mitochondria are abundant and pristine, decades of producing ATP generate oxidative stress through byproducts called free radicals, which eventually wear down and damage mitochondrial DNA and machinery. This damage results in fewer, less efficient power generators, lowering total cellular energy output, which individuals experience as real-world physical fatigue and mental fog. Aging is further accelerated by cellular senescence, a condition where damaged cells stop dividing but, instead of naturally self-destructing like healthy ones, linger behind as dormant "zombie cells." These senescent cells secrete a pro-inflammatory chemical mixture known as the Senescence-Associated Secretory Phenotype (SASP), which functions like a "bad apple" by poisoning healthy neighboring cells and tissues, creating a state of chronic biological pollution termed "inflammaging." Mitochondrial decay and senescence feed into one another in a vicious cycle that directly drives overall aging. However, longevity science highlights that healthy lifestyle habits, including regular exercise and periods of fasting, can support continued vitality by encouraging the development of new mitochondria and the clearing of this toxic cellular clutter.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6649) Is Your Cinnamon Causing Inflammation? The Hidden Risks of a Common Spice
Date:
July 16, 2026 05:28 PM
Cinnamon is widely praised for its ability to improve cellular glucose uptake and support insulin sensitivity, but the direct answer is yes - under specific conditions, consuming cinnamon can cause or trigger inflammation. While cinnamon naturally contains powerful anti-inflammatory polyphenols (like cinnamaldehyde), its potential to drive inflammation boils down to two distinct triggers: the specific variety you ingest, and your individual immune response to its volatile oils. 1. Coumarin-Induced Liver InflammationThe primary metabolic risk stems from Cassia cinnamon, which is the standard, inexpensive variety found on most grocery store spice racks. Cassia contains significant concentrations of a naturally occurring compound called coumarin.
2. Contact Hypersensitivity (Cinnamon Stomatitis)Cinnamaldehyde gives cinnamon its signature warmth and flavor, but it is also a documented contact allergen.
3. Gastrointestinal Mucosal IrritationBecause concentrated spice powders contain highly concentrated volatile oils, taking large doses on an empty stomach can physically irritate the delicate mucous lining of the upper gastrointestinal tract. This localized chemical irritation can mimic or exacerbate inflammatory discomfort in the stomach wall, resulting in heartburn, acid reflux, or cramping.Mitigating the Risk: Ceylon vs. CassiaIf you are leveraging cinnamon as a daily tool for metabolic health and blood sugar management, switching to Ceylon cinnamon (often labeled as "True Cinnamon") fundamentally changes its biochemical impact.
While cinnamon is highly regarded for improving insulin sensitivity and managing blood sugar, it can paradoxically trigger inflammation under specific conditions. The primary systemic risk stems from Cassia cinnamon, the common grocery store variety, which contains high concentrations of a compound called coumarin. When consumed regularly or in large therapeutic doses, coumarin can overwhelm the liver's metabolic pathways, leading to elevated liver enzymes and acute hepatic inflammation. Beyond liver toxicity, cinnamon can also incite localized inflammation; its volatile oil, cinnamaldehyde, can induce a Type IV delayed hypersensitivity reaction known as contact stomatitis - causing painful burning and swelling in the mouth - while concentrated doses can physically irritate the gastrointestinal lining. To safely harness the metabolic benefits of the spice without triggering these inflammatory responses, switching to Ceylon cinnamon ("true cinnamon") is the most effective strategy. Systemically, Ceylon contains only trace, negligible levels of coumarin (0.004% to 0.007%), making it safe for daily medicinal dosing, whereas Cassia contains significant levels (up to 1.0%) that require strict consumption limits to avoid toxicity. Visually and structurally, the two varieties are distinctly different: Ceylon features a light tan color with multiple thin, fragile, and tightly rolled layers, while Cassia is characterized by a dark reddish-brown hue and a single, thick, hard quill that is difficult to break.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6645) Does Methylation Effect Active Vitamin D3 Levels in the body?
Date:
July 08, 2026 12:43 PM
Yes, methylation directly and significantly impacts how efficiently your body converts Vitamin D3 into its active, usable form. This relationship operates on two distinct levels: epigenetic DNA methylation (which acts as a volume knob for the conversion enzymes) and the cellular methylation cycle (which shares a profound reciprocal feedback loop with active Vitamin D). To see exactly where methylation interferes, it helps to look at the standard two-step activation pathway:
1. DNA Methylation (The Epigenetic "Dimmer Switch")DNA methylation is an epigenetic mechanism where methyl groups are attached to a gene's promoter region, typically silencing or "turning down" its expression.
2. The Systemic Methylation Cycle Feedback LoopWhile S-adenosylmethionine (SAMe) is not a direct chemical cofactor required for the hydroxylation reactions themselves (which rely on NADPH and the cytochrome P450 enzyme network), the systemic methylation cycle and Vitamin D share a massive reciprocal cross-talk mechanism.
The Vitamin D "Non-Responder": Is Your DNA Dimming Your Supplement’s Power? Yes, higher active Vitamin D3 levels consistently cause homocysteine levels to drop. Large-scale observational studies and gold-standard randomized controlled trials (RCTs) confirm a distinct, inverse relationship: as your Vitamin D status optimizes, circulating total homocysteine decreases. When active D3 binds to the Vitamin D Receptor (VDR), it triggers specific genetic and cellular actions that clear homocysteine through multiple pathways. The Biological MechanismsActive Vitamin D doesn’t just lower homocysteine through one pathway; it exerts a multi-pronged push to keep the toxic amino acid from accumulating.1. Upregulation of Methionine Synthase (MTR)While active D3 supports the alternative BHMT (betaine) pathway, recent molecular research highlights an even more direct impact on the primary, folate-dependent remethylation loop.
2. Safeguarding Enzyme Function via Oxidative Stress ReductionThe primary enzyme responsible for clearing homocysteine, Methionine Synthase, is incredibly sensitive to oxidative stress. Under high inflammation or oxidative conditions, the cobalt atom at the heart of its B12 cofactor becomes oxidized, completely disabling the enzyme and causing a major homocysteine backup.
3. Preserving Liver and Kidney FunctionThe alternative remethylation pathway, BHMT, operates almost exclusively in the liver and kidneys. If these organs experience structural or metabolic strain, their capacity to process homocysteine drops drastically. Active Vitamin D protects hepatic and renal tissue architecture, ensuring the local cellular machinery required for the betaine-homocysteine conversion remains functional.What the Clinical Trials ShowIn human trials, the drop isn't just theoretical - it's highly measurable.The Clinical Evidence: In double-blind, randomized, placebo-controlled trials, individuals with low baseline Vitamin D and elevated homocysteine were given high-dose Vitamin D3 (e.g., 50,000 IU weekly) over a two-month period. The treatment groups consistently showed statistically significant drops in total serum homocysteine, alongside reductions in body mass index (BMI) and systemic inflammatory markers, while the placebo groups saw no change. If someone is dealing with stubborn hyperhomocysteinemia (elevated homocysteine) and pushing hard on methylated B-vitamins (like methylfolate and TMG/betaine) without seeing their numbers budge, a hidden Vitamin D deficiency or a high-methylation genetic barrier at the CYP2R1 liver enzyme is very frequently the missing link. Summary: The relationship between Vitamin D3 activation and the body's biochemical pathways operates as a highly coordinated, reciprocal feedback loop. On an epigenetic level, DNA methylation acts like a cellular dimmer switch for the liver enzyme CYP2R1, which is responsible for converting raw D3 into its circulating form. When the promoter region of this gene is heavily methylated, enzyme production is suppressed, explaining why some individuals act as clinical "non-responders" who struggle to raise their blood levels even with high-dose supplementation. Once Vitamin D is successfully activated, however, it turns around and directly reinforces the systemic methylation cycle by binding to the Vitamin D Receptor (VDR) and upregulating the BHMT gene, which is vital for maintaining the body's universal methyl donor (SAMe) pool. Conversely, maintaining robust levels of active Vitamin D3 plays a direct, clinically proven role in forcing circulating homocysteine levels to drop. When active D3 binds to its receptor, it triggers a multi-pronged clearance strategy by activating the Nrf2 cellular defense pathway, which upregulates Methionine Synthase (MTR) - the primary enzyme that converts toxic homocysteine back into harmless methionine. Furthermore, by acting as a powerful systemic anti-inflammatory, active Vitamin D lowers the oxidative stress that would otherwise oxidize and disable the delicate B12 cofactors inside these clearance enzymes. This dual action of increasing enzyme production while shielding existing enzymes from environmental damage explains why clinical trials consistently show significant reductions in serum homocysteine when Vitamin D status is optimized.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6644) Can DMAE Help With Cellular Cleanup?
Date:
May 28, 2026 01:38 PM
Yes, DMAE - and specifically its highly bioavailable pharmaceutical ester counterpart, centrophenoxine (meclofenoxate) - hits cellular cleanup mechanisms. However, the way it interacts with a stalled system in Parkinson's Disease (PD) is fundamentally different from standard macroautophagy upregulators like fasting or mTOR inhibitors. Instead of just forcing the cell to create more cleanup vesicles, DMAE addresses the structural and mechanical "traffic jams" that cause the system to stall in the first place. The Parkinson's Stagnation: An Autophagic Traffic JamIn Parkinson’s pathology, the primary breakdown in cellular quality control occurs within the autophagic-lysosomal pathway. The accumulation of misfolded a-synuclein proteins builds up into toxic aggregates (Lewy bodies). This doesn't just form static waste; it actively paralyzes the cell's transport machinery, halting macroautophagy, chaperone-mediated autophagy (CMA), and mitophagy (the clearing of damaged, radical-producing mitochondria).Here is how a healthy version of this pathway is structured: As shown above, a healthy cell relies on seamless transport where an autophagosome encapsulates debris and fuses with an acidic lysosome to form an autolysosome for enzymatic destruction. In a stalled Parkinson's state, this crucial fusion and trafficking step is paralyzed. How DMAE Alters Cleanup DynamicsDMAE approaches this bottleneck through two precise biochemical mechanisms:1. Re-greasing Vesicle Trafficking TracksTo build an autophagosome and move it to a lysosome, a neuron requires highly fluid lipid membranes.
2. Direct a-Synuclein DisruptionClassically, DMAE is famous in longevity research for dissolving lipofuscin - the cross-linked "wear-and-tear" pigment aggregate that accumulates in aging cells. While lipofuscin is structurally distinct from the amyloid-like sheets of a-synuclein, modern molecular profiling has revealed that DMAE derivatives possess a powerful cross-over effect:
Mechanics of Clearance: DMAE vs. Traditional Autophagy Inducers
Summary: In Parkinson’s disease, cellular cleanup stalls because toxic accumulations of misfolded alpha-synuclein proteins physically paralyze the autophagic-lysosomal pathway, creating a mechanical traffic jam that prevents waste-carrying autophagosomes from fusing with digestive lysosomes. Rather than simply triggering the creation of more cleanup vesicles like standard autophagy inducers do, DMAE and its highly bioavailable derivative, centrophenoxine, address this bottleneck structurally. It serves as a direct biochemical precursor to vital membrane phospholipids like phosphatidylcholine, restoring lipid bilayer fluidity and essentially "re-greasing the tracks" so stalled cellular transport machinery can resume normal trafficking and waste elimination. Beyond restoring membrane dynamics, DMAE compounds actively disrupt protein aggregation by changing the conformation of alpha-synuclein, which prevents individual monomers from stacking into the toxic, insoluble sheets that choke the cell's internal quality control. This action mirrors its well-documented ability to dissolve lipofuscin, the cross-linked "wear-and-tear" aging pigment that accumulates in aging cells. While free-base DMAE struggles to penetrate the central nervous system effectively due to competition with choline transporters, the lipophilic ester centrophenoxine easily crosses the blood-brain barrier, making it the superior vehicle for restoring neural membrane fluidity and clearing out stalled neurodegenerative debris.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6641) SCFAs Improve Mitochondria Function Throughout The Body
Date:
December 05, 2025 04:06 PM
Quick Summary: How SCFAs Help Mitochondria
Specific Benefits by Body Part1. Skeletal Muscle (Energy & Endurance)
2. Liver (Detox & Metabolism)
3. Brain (Neuroprotection)
4. Brown Adipose Tissue (Fat Burning)
Key Mechanisms
Does boosting Mitochondria boost overall body energy production and help people feel better?Yes, absolutely. Boosting mitochondrial function is one of the most effective ways to increase overall body energy and improve subjective well-being.Since mitochondria produce about 90% of the energy (ATP) your body uses, improving their function is like upgrading the engine in a car: you get more power, better fuel efficiency, and a smoother ride. Here is the breakdown of how boosting mitochondria translates to "feeling better" physically and mentally. 1. The Physical Energy Boost (ATP Production)When you improve mitochondrial density (the number of mitochondria) and efficiency (how well they work), you directly increase your "energy budget."
2. The Mental & Mood Boost (Neurotransmitters)The brain consumes 20% of your body’s energy despite being only 2% of your weight. It is incredibly sensitive to mitochondrial health.
3. How to "Boost" Them (Actionable Science)You can stimulate Mitochondrial Biogenesis (growing new mitochondria) through specific signals:
Connection to your previous questionThis connects directly to the SCFAs we discussed. When your gut produces SCFAs (like butyrate), they travel to your brain and muscles and literally feed these mitochondria, helping them produce this energy.Which specific supplements (like PQQ or CoQ10) have the strongest clinical evidence for triggering mitochondrial biogenesis?This is an exciting area of research because we now have human clinical trials showing we can actually "grow" new mitochondria (biogenesis) and clean out old ones (mitophagy) using specific compounds.Here are the top supplements with the strongest evidence for mitochondrial health, categorized by how they work. 1. The "Biogenesis" Trigger: PQQ (Pyrroloquinoline Quinone)PQQ is currently the gold standard for generating new mitochondria.
2. The "Quality Control" Agent: Urolithin AWhile PQQ builds new engines, Urolithin A recycles the old, broken ones.
3. The "Fuel" Supplier: CoQ10 (Coenzyme Q10)CoQ10 doesn't necessarily build new mitochondria, but the ones you have literally cannot work without it.
4. The "Signal" Booster: Nicotinamide Riboside (NR)This is a form of Vitamin B3 that boosts NAD+ levels.
Summary Table: What should you take?
Optimizing mitochondrial health is a systemic strategy that links gut health to overall vitality, largely driven by Short-Chain Fatty Acids (SCFAs) like butyrate, which act as both fuel and signaling agents to enhance energy production in the brain, muscles, and liver. By stimulating mitochondrial biogenesis (the creation of new energy factories via the PGC-1a gene) and fueling the Electron Transport Chain, SCFAs - along with targeted supplements like PQQ, CoQ10, and Urolithin A - directly increase ATP output while simultaneously clearing out damaged cells through mitophagy. This biological upgrade results in tangible benefits, including sustained physical endurance, sharper cognitive focus, and stabilized mood, effectively turning the body’s cells into more efficient engines that produce more power with less oxidative "exhaust."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6630) The Role of Vitamin D in Immune Health
Date:
May 24, 2024 03:28 PM
The Role of Vitamin D in Immune HealthVitamin D plays a crucial role in maintaining a robust immune system, acting as a vital nutrient that supports overall health. Unlike other vitamins, vitamin D functions as a hormone, interacting with various bodily systems to help modulate the immune response. This essential vitamin aids in the activation of T cells, which are critical for identifying and combating pathogens.
Sources of Vitamin DTo ensure adequate levels of vitamin D, it is important to consider both dietary sources and sunlight exposure. Foods rich in vitamin D include fatty fish like salmon and mackerel, fortified dairy products, and egg yolks. Additionally, sensible sun exposure enables the body to synthesize vitamin D naturally. However, factors such as geographic location, skin pigmentation, and the use of sunscreen can influence the amount of vitamin D produced by the skin. Make sure to supplement Vitamin D in a D-3 form for optimal absorption in your vitamin regimen.
Optimal Levels and SupplementationMaintaining optimal levels of vitamin D is important for immune health. Blood tests can determine vitamin D levels, with health professionals often recommending supplementation to address deficiencies. The right amount of vitamin D supplements varies depending on individual needs. Follow healthcare providers' guidelines to prevent potential toxicity from excessive intake.
Vitamin D and Immune ResponseResearch has shown that adequate levels of vitamin D are associated with a reduced risk of infections and improved immune function. Vitamin D enhances the pathogen-fighting effects of monocytes and macrophages—white blood cells that are important parts of immune defense—and decreases inflammation. This helps the body to fend off illnesses more effectively and recover quicker.
Public Health ConsiderationsPublic health organizations emphasize the importance of maintaining sufficient vitamin D levels for overall health. It is recommended to regularly monitor high-risk groups such as older adults, individuals with limited sun exposure, and those with specific medical conditions. Understanding the significance of vitamin D can improve health and boost the immune system. It is advised to get blood work twice a year to monitory vitamin D levels and supplement accordingly. In summary, vitamin D is indispensable for a well-functioning immune system. Ensuring adequate intake through diet, sunlight, and supplementation as needed can provide beneficial effects on health and enhance the body's ability to combat illness.
Take Action to Boost Your Immune HealthUnderstanding vitamin D's crucial role in supporting a healthy immune system, it's crucial to take proactive steps to ensure sufficient intake. Include vitamin D-rich foods like fatty fish, fortified dairy, and egg yolks in your diet. Consider D-3 supplements and aim for safe sun exposure to boost vitamin D levels. Don't hesitate to seek advice from healthcare providers regarding supplementation, especially if you fall into a higher-risk category for deficiency. Regular blood tests can help you monitor your vitamin D levels and adjust your intake accordingly. By Stay informed, take action, boost your immune health, lower infection risks, and improve overall well-being. Act now to incorporate these practices into your daily routine and fortify your body's natural defenses.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6601) Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?
Date:
December 07, 2023 12:12 PM
Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body. While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption. GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age. The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels. In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body. This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form. But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them. So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing! Liver HealthWhen it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ. Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds. During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances? But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker! The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning. So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being! Alcohol IntoxicationAlcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells. To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes. The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group. The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver. Nonalcoholic fatty liver diseaseNonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels. Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy. In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management. Beautiful SkinBy activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions. Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores. Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects. Skin LighteningSkin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract. The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women. In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH. Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin. The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities. In summary, the administration of
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6592) Magnesium Glycinate: An In-Depth Guide
Date:
November 04, 2023 10:53 AM
Magnesium Glycinate: An In-Depth GuideMagnesium is an essential mineral for the body, playing a crucial role in the regulation of blood pressure and numerous other bodily functions. The shortcoming of this nutrient can be addressed through the consumption of magnesium glycinate, a supplement also known as magnesium diglycinate and magnesium bisglycinate. Key Roles of Magnesium
This article delves into the details of magnesium glycinate, looking at its benefits, potential side effects, the recommended dosage, and more. Benefits of Magnesium GlycinateThe human body needs a significant amount of magnesium for optimal function. Although the best way to obtain nutrients is in their natural form, supplements like magnesium glycinate are available to enhance magnesium intake in individuals with low levels. Benefits of this supplement include:
Precautionary Measures
Conditions that may Benefit from Magnesium Glycinate
Sources of Magnesium Glycinate Nutritional sources rich in magnesium include legumes, nuts, seeds, whole grains, spinach, fortified breakfast cereals, yogurt, milk, and other dairy products. Recommended Dosage The amount of magnesium glycinate to be taken can vary. It is advised to consult a doctor before starting a magnesium glycinate regimen. Potential Side Effects Magnesium glycinate, like other dietary supplements, can cause side effects such as nausea, abdominal cramps, and diarrhea when taken in large or frequent doses. However, a study from 2013 indicated that magnesium glycinate is less likely to induce diarrhea compared to other magnesium supplements. Extreme doses could lead to magnesium toxicity, resulting in more severe side effects. Easy Ways to Consume More Magnesium One effective method of increasing magnesium intake is by incorporating dietary supplements into your daily regime. For instance, Solaray Magnesium Glycinate is a popular supplement that is widely recognized for its efficacy. It is an easily digestible form of magnesium that is gentle on the stomach and less likely to induce diarrhea. Solaray's supplement provides an accessible option for those looking to supplement their diet with magnesium, especially for individuals who might struggle to meet their nutritional requirements through diet alone. Conclusion Magnesium glycinate can be a beneficial supplement for individuals with magnesium deficiency. However, caution must be exercised in its consumption, with potential side effects and individual health conditions taken into account. As always, it is best to seek medical advice before starting a new supplement regimen.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6587) All-Natural Flea and Tick Repellent for Dogs
Date:
October 14, 2022 04:37 PM
At The Royal Treatment, we are always looking for ways to provide the best possible care for your furry friends. That's why we're excited to introduce our new all-natural flea and tick repellent for dogs! This product has been formulated by our very own Dr. Barbara Royal, DVM, CVA and is safe for dogs of all ages. Why You Should Use an All-Natural Flea & Tick Repellent for Dogs As pet parents, we want what's best for our furry friends. That's why we're always on the lookout for products that are safe, effective, and affordable. When it comes to flea and tick repellents, there are a lot of products on the market that contain harmful chemicals like DEET, synthetic pesticides, and pyrethrins. These chemicals can be toxic to both humans and animals, and can cause a host of health problems including skin irritation, respiratory distress, and even cancer. Our all-natural flea & tick repellent for dogs is made with essential oils that are safe for both humans and animals. It's also free of artificial colors and fragrances. And best of all, it's vet-formulated and approved! This product is ideal for dogs of all ages and can be used as often as needed. Simply spray it on your dog's coat before going outside, and reapply as needed throughout the day. We know that as a pet parent, you only want what's best for your furry friend. That's why we've formulated this all-natural flea & tick repellent for dogs. It's safe for both humans and animals, and can be used as often as needed. Simply spray it on your dog's coat before going outside, and reapply as needed throughout the day.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6506) The Many Benefits of Graviola(Diabetes, Liver, Parasites)
Date:
October 11, 2022 11:18 AM
Graviola, also known as soursop, is a small, green fruit that grows in tropical climates. The fruit, leaves, and seeds of graviola have been used for centuries in traditional medicine to treat a variety of conditions. Today, we know that graviola can help control diabetes and blood sugar problems, cleanse the liver, and remove parasites. These functions help in cases where underlying blood sugar imbalances and immune system weakness are persistent problems. Also, numerous studies of Graviola have shown selective cytotoxicities against several lines of cancer cells. Let's take a closer look at some of the ways graviola can benefit your health. Graviola and Diabetes Graviola can be helpful in managing diabetes and blood sugar levels for two reasons. First, graviola helps to increase insulin sensitivity. Second, graviola leaf extract has hypoglycemic properties, which means it can help to lower blood sugar levels. A study published in the Journal of Ethnopharmacology found that rats with diabetes who were given graviola leaf extract had significantly lower blood sugar levels than rats who were not given the extract. Graviola and the Liver Graviola can also help to cleanse the liver and protect it from damage. The liver is responsible for filtering toxins out of the body, so it is important to keep it healthy. Graviola helps to keep the liver healthy by reducing inflammation and protecting it from oxidative damage. A study published in the International Journal of Molecular Sciences found that graviola was able to protect the liver from oxidative damage in rats with liver disease. Graviola and Parasites In addition to its other benefits, graviola can also help to eliminate parasites from the body. Parasites can cause a wide range of problems including fatigue, gastrointestinal issues, and weight loss. A study published in Phytotherapy Research found that graviola was effective at eliminating parasites in rats infected with the parasite Ascaris suum. In Summary: Graviola is a small fruit with a big impact on health. It can help to control diabetes, cleanse the liver, and remove parasites from the body. Additionally, studies have shown that graviola has anti-cancer properties. If you are looking for a natural way to improve your health, Graviola may be worth trying!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6499) The Truth About Sugar: How It's Digested, Metabolized, and Why Too Much Can Be Dangerous
Date:
June 25, 2022 10:13 AM
What is glycation and what does it do to the body? Glycation is a process that occurs when glucose binds to proteins, lipids, or nucleic acids. This can damage tissues and lead to the formation of advanced glycation end products (AGEs). AGEs are toxic compounds that contribute to the development of chronic diseases, such as diabetes, atherosclerosis, and Alzheimer’s disease. The body has mechanisms to prevent glycation, but these become less effective with age. Additionally, certain lifestyle choices, such as smoking and a high-sugar diet, can increase the risk of glycation. Therefore, it is important to be aware of the risks and take steps to protect the body from this damaging process. How does sugar cause glycation? Sugar causes glycation in several ways. First, when sugar is present in the bloodstream, it can attach to proteins and lipids, forming new molecules called advanced glycation end products (AGEs). Once formed, AGEs can accumulate in tissues and cause damage. Second, sugar can also indirectly cause glycation by promoting inflammation. Inflammation triggers a release of immune system chemicals that can damage tissues. Third, sugar can also impair the body's ability to regenerate tissues. This is because glycation damages DNA, making it difficult for cells to divide and multiply properly. over time, this leads to a decrease in the body's ability to heal wounds and repair damaged tissues. As a result, sugar plays a significant role in the development of conditions such as diabetes and Alzheimer's disease. How can you prevent glycation from happening? There are several ways to help prevent glycation from occurring. First, it is important to control blood sugar levels by eating a healthy diet and maintaining a healthy weight. Exercise can also help to regulate blood sugar levels and prevent glycation. In addition, antioxidants may help to protect against glycation by scavenging sugar molecules before they can attach to other molecules. By taking these steps, you can help to prevent glycation and the age-related conditions that are associated with it. Should we be worried about sugar intake? Sugar is a complex topic, and there is still a lot of scientific research to be done in order to understand all of its implications. However, based on the current evidence, it seems that we should be at least somewhat concerned about our sugar intake. Numerous studies have linked sugar consumption to an increased risk of obesity, type 2 diabetes, heart disease, and certain types of cancer. And while sugar itself is not necessarily bad for you, the truth is that most of us consume far more sugar than we need. The average American consumes over 150 pounds of sugar every year, which is well above the recommended limit. So, while you don't need to eliminating sugar entirely from your diet, it is important to be aware of how much sugar you're consuming and to make sure that you're not overdoing it. What are some healthy alternatives to sugar? Sugar is a common ingredient in many processed foods, and it can be difficult to avoid. However, consuming too much sugar can lead to weight gain, cavities, and other health problems. Thankfully, there are a few healthy alternatives that can be used in place of sugar. Stevia is a popular choice, as it is derived from a plant, has no calories, and does not elevate blood sugar levels. Xylitol and erythritol are both sugar alcohols that have a lower calorie content than sugar and do not cause cavities. These substitutes can be found in most supermarkets, and they can help to make healthier choices when it comes to sweetening food and drink. So, while you don't need to eliminating sugar entirely from your diet, it is important to be aware of how much sugar you're consuming and to make sure that you're not overdoing it. There are a few healthy alternatives that can be used in place of sugar. Stevia is a popular choice, as it is derived from a plant, has no calories, and does not elevate blood sugar levels. Xylitol and erythritol are both sugar alcohols that have a lower calorie content than sugar and do not cause cavities. Our suggestion is Kal brand Stevia, it is a no after taste stevia with over 1800 servings, this is VitaNet's Recommendation. Try a sugar alternative in your next recipe and see how it tastes! You might be surprised at how good it can be.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6413) Can the Liver Be Repaired Once It Is Damaged?
Date:
April 29, 2022 11:33 AM
https://vitamins.vitanetonline.com/wp-content/uploads/liver-2934612_1920.png What is the liver and what does it do? The liver is a large, multi-functional organ that plays a vital role in the body. Its primary function is to filter the blood and remove toxins, but it also helps to regulate metabolism, store nutrients, and produce bile. The liver is divided into two main lobes, the right lobe and the left lobe. The right lobe is slightly larger than the left lobe and includes the quadrate lobe and caudate lobe. The left lobe contains the left lateral section and the medial section. The hepatic veins drain blood from the liver and pass it through the inferior vena cava to be returned to the heart. The hepatic arteries supply oxygenated blood to the liver tissue, while the portal vein carries nutrient-rich blood from the digestive organs. The bile ducts transport bile produced by the liver cells to the gallbladder, where it is stored until needed for digestion. The liver is a hardworking organ that performs many crucial functions in the body. By keeping it healthy, we can help to ensure that our entire body remains healthy and functioning properly. What can damage the liver and how does that damage occur? The liver is a vital organ that performs many important functions, such as filtering toxins from the blood and producing bile to help digest fats. However, the liver can be damaged by a number of different agents, including viruses, alcohol, and certain medications. Viruses such as hepatitis C and hepatitis B can cause inflammation of the liver, which can lead to scarring and eventually to liver failure. Alcohol abuse is also a major cause of liver damage, as it can lead to fatty deposits, inflammation, and scarring. In addition, certain drugs (such as acetaminophen) can cause toxic damage to the liver cells. If the liver is not functioning properly, it can result in a build-up of toxins in the blood, which can lead to serious health problems. Can the liver be repaired once it is damaged, and if so, how is that done? The liver is a amazing organ. It is responsible for so many important functions in the body, from filtering toxins to producing bile to breaking down fats. When it is damaged, it can often repair itself. This is because the liver has a high regenerative capacity. hepatocytes, which are the main type of liver cell, can divide and grow back quickly when necessary. In fact, as long as about 25% of the liver remains healthy, it can regenerate itself completely over the course of a few weeks. There are a number of ways to damage the liver, such as through alcohol abuse or viral infections, but fortunately there are also ways to help it repair itself. Eating a healthy diet, getting enough exercise, and avoiding toxins, take liver supporting supplements like milk thistle and NAC can all support liver health and regeneration. How can people prevent their livers from being damaged in the first place? The liver is a vital organ that plays an important role in metabolism. However, the liver can also be easily damaged by alcohol, drugs, prescriptions, and environmental toxins, which are in the foods we eat. To help prevent liver damage, it is important to avoid excess alcohol consumption or avoid it all together, take medication as directed and if you are on medications that cause liver damage to discuss alternatives that do not harm the liver, and eat a healthy diet along with taking liver supporting supplements. Additionally, it is important to get regular exercise, as this helps to keep the liver healthy and functioning properly. By taking these steps, people can help to prevent liver damage and keep their organs healthy. Are there any lifestyle changes or supplements that can help improve liver function even if it has been damaged already? Liver damage is a serious concern for many people, as it can lead to a number of health problems. While there is no guaranteed way to reverse liver damage, there are some lifestyle changes and supplements that may help improve liver function. One potential change is to limit alcohol consumption, as alcohol is known to be damaging to the liver, mixing alchol and drugs can enhance the progress of liver damage. Additionally, eating a healthy diet and exercising regularly can help improve overall liver function. There are also a number of herbal supplements that are thought to be beneficial for the liver, such as milk thistle and dandelion root. However, it is important to speak with a healthcare provider before starting any new supplement, as some may interact with other medications. What are the possible consequences of not repairing a damaged liver? Liver damage can have serious consequences if left untreated. Depending on the cause, there may be a variety of negative effects that result from an injured liver. For example, if the damage is due to excessive alcohol consumption, then scarring and inflammation of the liver tissue can interfere with its ability to filter toxins out of the blood. This can lead to a host of potentially dangerous health problems, including nausea, chronic fatigue, jaundice, and cirrhosis. You must address the cause before change for the good can happen. In addition, unresolved inflammation can increase one's risk of developing more serious conditions such as cancer or heart disease. To prevent these possible consequences, it is important to seek medical attention as soon as possible after suffering from liver damage. This will allow doctors to properly diagnose the issue and develop an appropriate treatment plan. Addressing the cause is always preferable over simply treating symptoms alone. Ultimately, taking action now can help you protect your health in the future. How can people find out if their livers need repair and where they should go for help if that is the case? When it comes to liver health, there are a number of ways to find out if your liver needs some repairs. One method is to get tested for elevated liver enzymes, which are indicative of problems with the organ. You can also watch out for certain symptoms, such as fatigue, bloating or skin discoloration. If you notice any of these markers, you may want to consult with your doctor or a specialist in liver disease, who can help determine the best course of action. Depending on the underlying cause of your liver problem, treatment options may include changes to your diet and exercise habits, medications or even surgery in extreme cases. Whatever route you choose, it is essential that you address any issues with your liver as soon as possible in order to protect your overall wellbeing. Generally, symptoms only show when liver function has dropped significantly. Liver damage can often go undetected until it has reached a advanced stage. This is because the liver has an incredible capacity for regeneration and can continue to function even when up to 75% of it has been damaged. As a result, symptoms of liver disease often only become apparent when the organ has been severely compromised. By that point, the damage may be irreversible and serious complications may have developed. Therefore, it is important to be aware of the early signs of liver damage so that treatment can be started as soon as possible. These include fatigue, weight loss, abdominal pain, and yellowing of the skin and eyes. Fortunately, Supplements like Milk thistle and NAC may help the body assist the liver in its repair. The liver is a hardworking organ that is constantly exposed to toxins. As a result, it is susceptible to damage. Fortunately, supplements like milk thistle and NAC may help the body assist the liver in its repair. Milk thistle contains silymarin, a compound that helps to protect the liver from damage. NAC is an amino acid that helps to remove toxins from the liver. NAC also helps to replenish glutathione, a substance that plays a key role in liver detoxification. Together, these supplements can help to keep the liver healthy and functioning properly. Whether you are looking for preventative measures to protect the liver or have an existing issue, it can never hurt to take either milk thistle, NAC, or both to support healthy liver function.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6396) Astaxanthin can boost your health
Date:
April 22, 2022 04:19 PM
Astaxanthin is a nutrient that has tremendous potential for improving human health, but it's not well known. Most people have never even heard of astaxanthin, let alone know how beneficial it can be for their health. Astaxanthin is a uniquely powerful nutrient that can improve your health in ways you never imagined. It's hundreds of times more potent than some of the world's strongest nutrients at stopping oxidative stress, and it offers a wide range of other benefits as well. There are a variety of natural astaxanthin sources. The most well-known source is the microalgae haematococcus pluvialis, which is often used as a dietary supplement. Other natural sources include shrimp, lobster, and crab. Salmon, trout, and other red-fleshed fish get their pink color from astaxanthin, which they acquire by eating krill and other small crustaceans. Astaxanthin is also found in certain plants, including spirulina and chlorella. In addition, some fungi produce astaxanthin, and it is sometimes added to poultry feed to provide a healthy pigment for the flesh. Astaxanthin is a powerful antioxidant that has a range of potential health benefits. It is thought to protect against heart disease and cancer, and it may also help to reduce inflammation.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6387) Curcumin and Grapeseed
Date:
September 01, 2020 11:03 AM
Smoking, Chemical exposure, pesticides, nutrient deficiencies, to much sun exposure, and over the counter drugs and prescriptions can cause cancer. In the news, there are forever chemical roundup found in our water supply, it is no wonder we are laden with cancer as a society. Fortunately, a healthy cancer preventing diet along with natural plant compounds can be far more effective and cost a lot less than conventional care alone. Two top suggested natural medicines available right now are curcumin and grape seed extract. These two herbs are an amazing pair, curcumin is a fat soluble herb to fight oxidation on the fatty oil side in the body and grape seed extract is water soluble, making it a great antioxidant to fight oxidative stress on the water side of a cell. Cells in the body are made up of oil(fats) and water. The impact of both together on your health is virtually miraculous. Curcumin neutralizes unstable free radicals that take electrons from nearby molecules, and stop them from creating a cascade of damaged cells. It also reduces inflammation reduces inflammation markers in the body to prevent prevent tissue degradation. Curcumin has been shown to stop the changes that happen from free radical damage causing normal cells to become cancerous, and tumorous formations, and can even stop cancer from metastasizing or migrating to other parts of the body. Published studies anticancer activity have found that it can suppress breast, prostate, liver, skin, colon and lung cancer cells. Curcumin Must Be Absorbed To Be Useful One of the challenges or using curcumin for cancer prevention and treatment is that not all curcumin extracts are easily absorbable into the body. Blending curcumin in Turmeric essential oil enhances absorption and provides the additional benefits of ar-turmerone, a compound in the oil. Curcumin Makes Chemo More Effective There is big potential for curcumin when used with conventional treatment. BCM-95 curcumin, through research, has shown to sensitize human colon cancer cells to chemotherapy treatment where it would otherwise be resistant to this form of treatment. In some cases tumor recurrence rates can be as high as 60% but when treated with curcumin while under conventional treatment, curcumin boosted the effectiveness of the chemo drug 5-fluorouracil against cancer stem cells. Curcumin has great potential in conjunction with conventional cancer treatment and recovery. It has been found that as chemo treatment progresses, cancer cells become resistant to the chemo treatment and the dosage has to be increased as the treatment continues increasing the toxic side effects. Fortunately, curcumin taken in conjunction with conventional cancer treatment can improve the effectiveness of chemo and so the dosage can be lowered reducing the toxic side effects for individuals. This is good news! Curcumin Protects The Body During Cancer Treatment In a clinical study with curcumin, it showed to alleviate side effects of one of the most common treatments of prostate cancer known as external beam radiotherapy (EBRT) where the doctor uses radiation to destroy tumorous cancel cells. This sort of therapy has many side effects making it a difficult therapy for most men. I often causes sexual dysfunction, digestive problems, urinary tract pain and loss of control. The higher the radiation dosage the more effective the treatment is but this causes significant discomfort, that is why most doctors lean towards lower dosages which makes the treatment less effective. The clinical study administered 3000mg of BCM-95 curcumin that is 1000mg x 3 per day or a placebo one week before therapy started and during the treatment length. Each capsule of curcumin contained curcuminoids, curcumin, demethoxycurcumin, bisdemethoxycurcumin, and essential oil of turmeric, this is a full spectrum curcumin supplement. At the end of the treatment which lasted 20 weeks the most dramatic difference between the two groups in the study was urinary symptoms. The curcumin group said a 50% decrease in symptoms or side effects of the radiation. Also, researchers noted that the curcumin did not reduce the efficacy of the EBRT.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6362) Non-Intoxicating Hemp and CBD
Date:
December 03, 2019 04:37 PM
Benefits of Hemp Non-Intoxicating Agricultural hemp keeps you healthy, doesn't get you "high." Nutrient Rich Hemp contains excellent nutritional value, providing essential nutritional components called Essential Fatty Acids (EFA) that the human body does not product naturally, and must be consumed through the diet. Further, emerging scientific research supports the consumption of CBD from hemp oil for general well-being. Good for the Earth Hemp sequesters CO2 and leaves the soil in better condition than before it was planted. Eco-friendly Not only is hemp renewable and fast-growing, nearly every part of the plant is useable - for food, fiber, building materials and fuel, with an estimated 25,000 uses! Agricultural Hemp (Outdoor Grown)
The Bad Side of Medical Cannabis (Indoor Grown)
Industrial Hemp based CBD has many uses have you given it a try yet?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6351) Gardenia, widely used in TCM, found to prevent cognitive impairmentand neurotoxicity
Date:
May 09, 2019 09:56 AM
Nobody wants to think about losing their memories as they begin to age. Luckily, a Chinese medicinal herb called gardenia has been shown to contain components that can help improve cognitive function. Scientists studied mice that were given daily doses of gardenia, and the research revealed that a component called GJ-4 had the ability to help repair cognitive damage, reduce brain inflammation, and even help expand the body's ability to hold antioxidants which help promote brain function. Key Takeaways:
"In the study, researchers looked at Chinese herbs, which have been used medicinally for thousands of years, as a good source for potential drugs for Alzheimer’s." Read more: https://www.naturalnews.com/2019-03-28-gardenia-found-to-prevent-cognitive-impairment-and-neurotoxicity.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6291) Barley grass is one of the best green super foods for improving gut health
Date:
May 08, 2019 03:57 PM
Barley grass — the leaf of young stalks of barley — has lots of health benefits, especially for digestion. Its anti-inflammatory properties may explain why it seems to help prevent the development of ulcerative colitis. Barley grass is an excellent source of multiple B vitamins, as well as vitamins C and K, calcium, potassium and other important minerals. It’s also great for detoxification of the body, thanks to its bountiful supply of a antioxidants and chlorophyll. Barley grass makes a great ingredient to juice mixes or smoothies, and can also be bought as a supplement. Key Takeaways:
"In addition, barley grass is rich in digestive enzymes, which are substances that can help eliminate toxic and indigestible materials in food." Read more: https://www.naturalnews.com/2019-03-31-barley-grass-green-superfood-for-improving-gut-health.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6286) Oolong tea inhibits the growth and progression of breast cancer cells
Date:
May 08, 2019 03:07 PM
Many persons drink tea for relaxation, stress relief, and to get a caffeine fix but little do they know that drinking tea can help to inhibit the growth of breast cancer cells. Some researchers in both America and China who worked together have found that drinking tea can lead to DNA damage in the cells of breast cancer. Since this tea can be used to prevent also the progression of a tumor, it is hoped that one day they can be a non-toxic means to prevent the growth of breast cancer. In the USA alone, about 250,000 women were diagnosed with breast cancer in 2018 and about 41,000 are expected to die from the disease. Although there are improvements in the screening for breast cancer, and in treatment, it is noted that more needs to be done to help women. The researchers discovered that tea has long been used in medicinal treatment in China for centuries and reckoned that black tea is used more often than green tea and oolong tea. And although the benefits of green tea in treating cancer has long been known, the use of oolong tea for cancer is not known, so the researchers sought out this tea in their experiment. Using patients from Fujian, China, where oolong tea is grown mainly, they found out that there was a lower incidence of cancer among people who take oolong tea. Key Takeaways:
"Like black and green teas, oolong tea contains several vitamins, minerals, and helpful antioxidants." Read more: https://www.naturalnews.com/2019-04-11-oolong-tea-inhibits-the-growth-and-progression-of-breast-cancer-cells.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6284) Traditional Pacific Island medicine, kava kava, found to alleviateanxiety
Date:
May 07, 2019 04:27 PM
Kava kava was found to alleviate anxiety symptoms by a study done at Gran Valley State University in Michigan. The study reported that it was safe if used for less than eight weeks. This medicine can be found in the Pacific and helps the many people suffering phobias and major depressive disorders. Approximately one in fourteen people suffer from some anxiety. The medicine was found to be harmful to the liver, and even toxic if taken longer than eight weeks. It was also found to be more effective for females and younger people. Longer term studies will be done to determine overall safety. In the meantime, other treatments include using skullcap, Valerian root, passion flower and Ashwagandha. Key Takeaways:
"A lot of people suffer from anxiety. The World Health Organization (WHO) estimates that one in 14 people around the world has an anxiety disorder, making it one of the most common mental disorders." Read more: https://www.naturalnews.com/2019-03-13-kava-kava-can-alleviate-anxiety.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6276) Cocoa isn’t just delicious – dies show it fights fatigue, too?
Date:
April 30, 2019 04:18 PM
A surprising new study presented by the Journal of Neurology, Neurosurgery and Psychiatry suggests that drinking cocoa can offer surprising relief to the fatigue associated with Multiple Sclerosis. Fatigue is one of the most common symptoms of MS, and because of the complicated nature of the disease, it is hard to treat this symptom. However, the study found that patients who drank a high-flavonoid blend of cocoa for six weeks reported significant levels of relief. This is one of several recent studies attesting to the benefits of dark chocolate. Key Takeaways:
"Turns out that a warm cup of (any drink) flavored with cocoa is more than just a tasty treat. It has some big health benefits, too." Read more: https://www.naturalhealth365.com/cocoa-chronic-fatigue-2922.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6228) Modified citrus pectin helps to reduce heavy metal toxicity by 74percent, study says
Date:
April 25, 2019 04:54 PM
As you may know, heavy metals are everywhere, in our water, food, dental fillings, and air. Fortunately, according to the latest research, modified citrus pectin is a substance that can help to safely remove these toxic metals from the body. The accumulation of heavy metals in the body not only can lead to chronic disease, but it also compromises the body's ability to heal from illness. Some common toxic heavy metals are lead, mercury, and cadmium. To reduce your body's burden of heavy metals, take 15 grams of the product PectaSol three times a day. Key Takeaways:
"Mercury, a known neurotoxin, is found in fish such as swordfish and shark, as well as in “silver” dental fillings. The crazy part is: we know that mercury can seriously affect the nervous system, causing tremors, loss of coordination, muscular spasms and even death." Read more: https://www.naturalhealth365.com/modified-citrus-pectin-2824.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6187) Field elm bark protects against liver damage, gastric ulcers andhigh blood pressure
Date:
April 25, 2019 04:51 PM
Field elm, which is known for its health benefits, is now being touted for helping with blood pressure, gastric ulcers, and liver damage. Researchers in France and Algeria found that field elm acted as an antioxidant which relaxed the coronary artery and protected the stomach from ulcers and the liver from toxins. There are various types of elm, some are good for skin irritations, diarrhea, heartburn, sore throats, or cramps. The trees are known for their strong wood. Key Takeaways:
"The researchers also saw that the extract can protect the stomach from ulcers and protect the liver from toxic substances. In addition, the extract also exhibited a relaxing effect on the coronary artery." Read more: https://www.naturalnews.com/2019-03-12-field-elm-bark-protects-against-liver-damage.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6186) Is this cruciferous vegetable the key to brain regeneration?
Date:
April 24, 2019 03:12 PM
Scientists have been researching ways of achieving brain regeneration for decades, but the article suggests that cruciferous vegetables is a method of regenerating the brain. An MIT scientist discovered that the growth of nervous tissue is aided by phyto-substances, which is a nutrient that can be found in common vegetables, like broccoli. A compound found in broccoli also has more positive effects on the body, as it has anti-inflammatory properties. Broccoli is helpful for elderly patients that suffer from degenerative diseases. Key Takeaways:
"This natural process of brain regeneration is expedited by certain beneficial phyto-nutrients, and hampered by certain toxic elements." Read more: https://www.naturalnews.com/2019-03-09-is-this-cruciferous-vegetable-the-key-to-brain-regeneration.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6177) Research says flavonoids can flush out arsenic from the body
Date:
April 20, 2019 11:36 AM
Thru environmental and food processes, we are exposed to many chemicals that are either ingested or absorbed thru respiration or through the skin. These toxic materials can be gotten rid of thru the foods we eat. A nutritional component called flavornoids, which are found the colors of various fruit and vegetables. The brighter the color, the more they contain. Flavornoids can not only help to rid the body of organic toxins, but inorganic as well. Key Takeaways:
"In a study published in the journal Nutrition Research, scientists from the U.S. and Mexico found that these nutrients help eliminate a toxin called inorganic arsenic from the body." Read more: https://www.naturalnews.com/2019-02-27-research-says-flavonoids-can-flush-out-arsenic-from-the-body.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6145) Study proves the antifungal potential of thyme essential oil
Date:
March 22, 2019 11:27 AM
The essential oil thyme isn’t just for cooking! Derived from the thymus vulgaris plant, this potent essential oil has been found to have strong antifungal and antioxidant properties. The powerhouse oil has been found to be effective against infections caused by Candida, Aspergillus, and Trichophyton. This perennial herb has been used for generations to treat coughs, headaches, constipation, and kidney issues. One study in the Journal of Pharmacology even showed that thyme is promising in the prevention and treatment of breast cancer. Key Takeaways:
"From these results, the researchers concluded that thyme essential oil has potent antifungal and cytotoxic properties, highlighting its potential use as a natural remedy for fungal infections and cancer." Read more: https://www.naturalnews.com/2019-01-24-antifungal-potential-of-thyme-essential-oil.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6089) CBD Oil: Health Benefits and Risks
Date:
February 12, 2019 01:14 PM
CBD is currently being touted as a new treatment for a range of health concerns. However, we do not yet fully understand its long term effects. CBD has been shown to effectively treat epilepsy and have some success as an anti-inflammatory medicine. CBD is not considered to be addictive according to the WHO. It also does not have the intoxicating effects that THC has. However, some people do experience side effects including sleepiness, fatigue, and diarrhea. Key Takeaways:
"CBD oil is thought to have potential benefits for the treatment and management of a wide variety of disorders due to its antioxidant, anti-inflammatory, neuroprotective, antipsychotic, analgesic, and muscle relaxing effects, among others." Read more: https://www.news-medical.net/health/CBD-Oil-Health-Benefits-and-Risks.aspx
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6021) There is a STRONG link between exposure to endocrine-disruptingchemicals and vitamin D deficiency
Date:
January 22, 2019 04:39 PM
Endocrine-disrupting chemicals such as BPA are a group of over 80,000 manufactured chemicals that are present within the products that we use on a consistent basis. These chemicals can unfortunately lead to many health implications such as cancer, heart disease, and diabetes. Studies have even shown that those who are exposed to higher levels of EDCs are more prone to developing Vitamin D deficiencies. All of these harmful health risks show just how dangerous these man-made chemicals can be to our bodies. Key Takeaways:
"But recent research has shown that the hazards of BPA and other endocrine disruptors can even cause vitamin D deficiency — which can cause a whole host of other health issues." Read more: https://www.naturalnews.com/2018-12-22-strong-link-endocrine-disrupting-chemicals-vitamin-d-deficiency.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5982) Eating cruciferous greens help your immune system fight offintestinal pathogens
Date:
January 13, 2019 04:10 PM
The Francis Crick Institute has published new research on the useful properties of cruciferous vegetables in protecting against pathogens that attack your gastrointestinal tract. According to this research, kale, broccoli, and cauliflower can all help reduce your susceptibility to inflammatory bowel diseases. They do this by helping to mitigate the effects of a compound called Cyplal, which can inhibit your body’s ability to use a separate substance called aryl hydrocarbon receptor (AhR). This is good because when Cyplal interferes with AhR, it can leave you more vulnerable to gut parhogens. Key Takeaways:
"An article in The Francis Crick Institute news page reported that cruciferous vegetables are particularly beneficial when it comes to shielding the intestine from disease-causing microorganisms." Read more: https://www.naturalnews.com/2018-12-18-eating-cruciferous-greens-help-your-immune-system-fight-off-intestinal-pathogens.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5960) Peppermint essential oil exhibits powerful antifungal activity
Date:
January 10, 2019 08:47 AM
Researchers in India had a problem: fungi in grains that are stored in bulk where making people sick. grains once coated with industrial chemicals to prevent this dangerous fungi from forming prevented the food borne illness, but posed a separate threat to human and animal health in their own right. They decided to try peppermint oil, which possesses anti microbial, anti fungus, and anti oxidative properties to coat the grains for storage as a natural and healthy alternative and have had stellar results in not only repelling the fungi, but vermin as well. Key Takeaways:
"Indian researchers believe the essential oil of the plant can serve as a natural fungicide for Fusarium head blight." Read more: https://www.naturalnews.com/2019-01-02-peppermint-essential-oil-powerful-antifungal.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5951) Study: PQQ (pyrroloquinoline quinone) may prevent and even reverseAlzheimer's
Date:
January 04, 2019 08:12 AM
Pyrroloquinoline quinone (PPQ) is a microbe that is derived from plants, and it is showing to have neurological benefits that are associated with the prevention of Alzheimer's progression. This particular microbe is able to reduce inflammation in the brain, which can lead to several neurological conditions. It also helps patients in post-stroke recovery because it is able to reduce the area of the brain that is impacted by stroke activity. Most importantly, it helps in the prevention of Alzheimer's due to how it can neutralize levels of oxidative stress. Key Takeaways:
"Glutamate is an important chemical in the brain, but too much of it results in excitotoxicity, a risk factor in both stroke and neurodegenerative disease. PQQ protects the brain from overstimulation by glutamate and the resulting death of brain cells." Read more: https://www.naturalnews.com/2018-12-15-ppq-can-prevent-alzheimers.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5928) PQQ is effective in combating neurodegeneration that can affect theaging brain
Date:
December 21, 2018 08:53 AM
A nutrient called Pyrroloquinoline quinone (PQQ) has shown potential for combating the degenerative neurological symptoms of Alzheimer’s, according to research published by Life Extension. Mice that were given a PQQ supplement developed smaller deposits of toxic proteins in their brains compared to the mice that did not, and also demonstrated better recall, memory, motor skills and learning relative to the control group. Other research suggests PQQ may help with Parkinson’s symptoms, and improve blood circulation within the brain. Key Takeaways:
"But there are many ways in which a person can reduce their risk of neurodegeneration as they age, like healthy eating." Read more: https://www.naturalnews.com/2018-12-13-pqq-combats-neurodegeneration-that-can-affect-the-aging-brain.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5916) What's The Difference Between Niacin And Niacinamide
Date:
December 19, 2018 08:31 AM
When it comes to Vitamin B3, not all forms of Niacin are created equally. Aside from the risk of allergens and impurities, there are also separate forms with critical distinctions. The pure form is made solely of nicotinic acid which causes the flushing effect when it is taken by humans. The flushing effect is a redness that starts in the face and expands outwards through the rest of the body. It can make the skin feel warm, dry, and itchy for half an hour. The flushing effect is associated with vascular dilation that helps open up the tiny capillaries and blood vessels to clean out all the toxic junk they may have accumulated. Nicotinic Acid Lowers Cholesterol Nicotinic acid is also associated with increasing HDL levels in the body to prevent heart disease and plaques from accumulating on the interior walls of arteries. Nicotinic acid is also known to lower the LDL and VLDL bad cholesterols that clog up arteries and lead to heart attacks and strokes. Other Benefits of Vitamin B3 Vitamin B3 plays a critical role in building enzymes that help us carry out over 200 physical functions in the body. It is not produced naturally but is absorbed from foods such as yeast, green vegetables, milk, eggs, legumes, and fish. Aside from cardiovascular health, it plays a critical role in nervous health and sex hormone production. How Does Niacinamide Differ? Niacinamide is a water-soluble form of Niacin that is used to treat deficiencies or for therapies when patients need to take higher doses regularly to treat pellegra and the deficiencies that lead to it. When an excess of Niacin is built up in the body, your body may store it in this form. The chief distinction between this water-soluable hybrid and nicotinic acid is the effect on cholesterol and vascular dilation. Although flushing can be reduced by taking nicotinic acid daily and building up a tolerance to the effects, it is harder on the liver and more burdensome on the body to metabolize it in the high doses used for therapy of many illnesses: ADHD, Schizophrenia, nervous problems, migraines, and arthritis, among others. It is the preferred choice for maintaining a consistent and steady level of Vitamin B3 in the body and loaded into many beauty and skin products for women. What Other Forms Can I Take? You can take any form of the vitamin on a daily basis or supplement it with nicotinic acid when you need some additional flushing effect. You will notice that Niacinamide causes some symptoms of drying and itching that are similar to flushing when you take it in high doses. The no-flush formulation is called inositol hexanicotinate and made up from Vitamins B3 and Inositol Vitamin B8. The inositol acts as an additional buffer that makes inositol hexanicotinate easy to digest and take 1600 mg without side-effects: nausea, itching, flushing, dizziness, gout, liver damage, diabetes. Although multi-vitamin formulas and even fortified foods like breakfast shakes and cereals suggest that you are getting a full dose of B3 in each serving, this is very unlikely. The better choice is to take specifically formulated capsules rather than multivitamins if you are using it for therapeutic reasons.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5911) Compelling study confirms the therapeutic effects of curcumin inremoving fluoride from our bodies
Date:
December 03, 2018 02:03 PM
According to statistics recently released by the CDC, 66.3% of U.S. citizens are being exposed to fluoride poisoning through the country's public water supplies. The good news is that a study in Pharmacognosy Magazine points to curcumin as a natural solution to this growing problem. According to this Indian study, curcumin can protect our brains from fluoride poisoning. If you cannot afford to install a whole-house water filter in your home, curcumin may be a safe and affordable option to protect your family from the dangerous neurological effects of fluoride. Key Takeaways:
"The researchers looked specifically at fluoride-induced toxicity on the mice’s brains, including the chemical’s impact on lipid peroxidation, or rancidity, in brain tissue. They also evaluated markers of malondialdehyde, or MDA, a well-known marker of oxidative stress and oxidative damage, in the brains of mice from each test group." Read more: https://www.naturalnews.com/2018-11-26-curcumin-removing-fluoride-from-the-body.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5869) One more reason to supplement: Probiotics reduce cadmium toxicity
Date:
November 26, 2018 02:52 PM
A new study published in the Journal of Medicinal Food claims that probiotic supplements can aid with the reduction of cadmium toxicity. Researchers found that probiotics actually help eradicate a body's cadmium by fastening to their bacterial cell wall and then remove them via feces. If a person is looking to lower their exposure to cadmium then they might want to stop smoking and if they don't smoke then also avoid inhaling another person's cigarette smoke as well. Key Takeaways:
"Lower cadmium levels can also be found in vegetables, cereals, and starchy roots. It has toxic effects on the kidneys, the skeletal system, and the respiratory system. It is also classified as a human carcinogen." Read more: https://www.naturalnews.com/2018-11-22-one-more-reason-to-supplement-probiotics-reduce-cadmium-toxicity.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5860) Natural matcha green tea extract found to effectively kill breastcancer cells
Date:
November 12, 2018 02:51 PM
Everyone knows that green tea is healthy for you but not everyone is aware of just what it can do for your body. Now, this natural green tea extract is being used for more than little get together's at your local Starbucks. It is beginning to be used for medicinal purposes as studies have shown it to be effective in killing breast cancer cells. More tests still have to be done but this is a massive revelation. Key Takeaways:
"When you’re making yourself matcha, be sure you do not boil it as this could compromise its antioxidant effects." Read more: https://www.naturalnews.com/2018-11-05-matcha-green-tea-extract-kill-breast-cancer-cells.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5828) Research indicates that turmeric may help mitigate the growth ofMRSA superbugs
Date:
November 06, 2018 03:51 PM
There are a lot of things that scientists are researching on a daily basis. Plenty of these scientists are in different fields and sectors over the things that they are researching. In this particular case, scientists were focusing on how to slow down the massive growth of these MRSA super bugs. Some people know what they are while other people have absolutely no idea. The truth of the matter is that they found that turmeric might be good to combat the growth of these things. Key Takeaways:
"Previous research shows that curcumin can have synergistic effects with certain antibiotics." Read more: https://www.naturalnews.com/2018-10-14-turmeric-mitigate-the-growth-of-mrsa-superbugs.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5820) Multiple studies show using CBD Oil for sleep disorders may be yoursafest bet
Date:
November 06, 2018 03:51 PM
There are a lot of people that struggle with sleeping disorders. More people than you realize are ones that cannot get a good night sleep on a regular basis. It is something that really takes a toll on their bodies and can be really bad for their physical health. Understanding how to get enough sleep in your life is crucial to long term health. These new studies are showing that CBD oil is so important and could be the best bet for these individuals. Key Takeaways:
"Although medical cannabis is very effective in inducing sleepiness, many people do not want smoke or ingest weed. Also, many do not enjoy the psychoactive effects of the cannabinoid tetrahydrocannabinol (THC)." Read more: https://www.healthnutnews.com/multiple-studies-show-using-cbd-oil-for-sleep-disorders-may-be-your-safest-bet/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5818) Brewer's yeast, a potential probiotic?
Date:
September 07, 2018 10:52 AM
Probiotic is current trend amongst consumers and are increasingly popular for their health benefits.brewers yeast is an essential commodity for making bread and beer.A study reveals brewers yeast tolerant to various temperatures high concentration of bile salt and sodium chloride gastric juice, intestinal environment, alpha-amylase, trypsin, and lysozyme,it produces organic acids and exhibits resistance against drugs.brewers yeast can absorb cholestrol and can also produce killer toxins and also demonstrated better antibacterial activity against gram-negative bacteria than gram-positive.brewers yeast also produces enzymes that enhance nutrient utilisation in the gut. Key Takeaways:
"Ingestion of brewer’s yeast was also considered safe as it did not cause any toxic side effects based on the results of toxicity tests." Read more: https://www.naturalnews.com/2018-08-11-brewers-yeast-a-potential-probiotic.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5752) One of the most precious spices in the world, saffron can be usedas an alternative cancer treatment
Date:
September 04, 2018 09:53 AM
Saffron is not only a tasty spice highly valued to culinary chefs, but it also has anti-cancer properties, according to a recently published article. Not only does saffron kill cancerous cells, but it is also selective in which cells it kills, meaning it doesn't harm non-cancerous cells. Saffron, although expensive, also has many other benefits. It can fight depression, improve skin, balance hormones, combat stomach pain, and even give sexual activity a boost. Saffron is a highly valued spice for good reason due to it's contributions to overall health. Key Takeaways:
"What’s more, these compounds display selective toxicity against cells; that is, they ultimately kill cancer varieties without harming normal ones." Read more: https://www.naturalnews.com/2018-07-31-saffron-can-be-used-as-an-alternative-cancer-treatment.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5742) Borage seed oil found to mitigate effects of radiation therapy on the liver
Date:
August 19, 2018 09:53 AM
Borage seed oil is typically used to treat the following health problems, rheumatoid arthritis, chest congestion, cough, depression, premenstrual syndrome, and menopausal symptoms. It is often used for hair and skin conditions such as hair loss, eczema, and Acne. borage oil contains a powerful anti-inflammatory compound known as gamma-linolenic acid however, borage oil is unique in that its GLA content is remarkably high.Also known as starflower, borage (Borago officinalis) is an herbaceous flowering plant.As a common herbal treatment in traditional medicine practices for hundreds of years, borage oil has numerous uses ranging from treating skin flare-ups to lowering pain.The most beneficial aspect of using borage oil either topically on the skin or internally in capsule form is it has strong anti-inflammatory effects.Borage oil is becoming increasingly popular as a natural anti-inflammatory supplement because it has one of the highest amounts of GLA of all seed oils.GLA is one type of omega-6 “essential” fatty acid that the body cannot make on its own, so we must get it from outside sources.The mechanisms of [borage oil] that provide protection against gamma-irradiation-induced toxicity may be explained by its antioxidant activity, inhibition of MDA, and prevention against GSH depletion due to its high content of GLA. Therefore, [borage oil] may be used as a beneficial supplement for patients during radiotherapy treatment.Borage can be helpful for treating a wide range of both short- and long-term illnesses like Bone loss and osteoporosis,skin disorders,Rheumatoid arthritis pain,managing diabetes,Dealing with stress, Hormonal imbalances, including adrenal insufficiency,respitory distress like bronchitis, colds, coughs and fevers,Alcoholism,preventing heart diseases and Inflammation causing pain and swelling. Borage oil is often used along with evening primrose oil supplements to further increase the anti-inflammatory and pain-reducing effects. Key Takeaways:
"Also known as starflower, borage (Borago officinalis) is an herbaceous flowering plant most known for being the source of borage oil." Read more: https://www.naturalnews.com/2018-08-17-borage-seed-oil-found-to-mitigate-effects-of-cancer-treatment-the-supplements-antioxidant-activity-reduces-damage-to-liver-from-chemicals-according-to-study.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5713) CV Sciences, Inc. Announces Landmark Publication on the Toxicology and Safety Assessment of ...
Date:
August 09, 2018 09:53 AM
The scientific study of the analysis of CBD oil got a major push recently. It's been almost 40 years since the last thorough toxicological safety assessment was run on a CBD oil. However, recently CV sciences had AIBMR Life Sciences Inc. perform a complete array of toxicological studies on Plus CBD oil, the company's consumer-lauded hemp cannabidiol oil. The study attested to the safety of oral consumption of the product. The study conclusions, which have been shared in a peer-reviewed journal, attest to the fact that the oil was discovered to be non-clastogenic, non-mutagenic and non-genotoxic. A spokesperson for CV Sciences noted that the company was "thrilled" and would encourage all CBD companies to allow such studies to be conducted for their own base materials. Key Takeaways:
"The toxicological assessment is the first known published data of its kind since the 1980 Rosenkrantz et al.’s publication with respect to toxicology data on CBD, Cannabichromene and hashish oil." Read more: http://markets.businessinsider.com/news/stocks/cv-sciences-inc-announces-landmark-publication-on-the-toxicology-and-safety-assessment-of-base-material-of-its-pluscbd-oil-products-1027104828
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5701) Anxious Pets? Hereâ??s How Hemp Can Help
Date:
July 26, 2018 05:53 PM
Separation anxiety is a real concern for pets and their owners. When dogs, for example, are left alone and unhappy they can act out in a number of negative ways, which can include urinating and defecating, chewing and scratching and trying to escape. While behavior modification can at times ease the symptoms, owners are looking into a way to alleviate the sense of anxiety their pets fel with CBD oil, which is a compound available through the hemp plant. The oil affects the neurotransmitters in the brain, also boosting the feel-good hormone serotonin. In this way the dog's anxiety may be alleviated. And, it may be a good choice, as study has shown 75% of pet-owners using CBD felt that it was an effective choice for their pet. Because hemp-based products are low in THC, the psychoactive compound found in marijuana, they are a better and usually legal choice. Regardless, it is always wise to seek out a veterinarian's advice. Key Takeaways:
"CBD is a compound found in both marijuana and its close cousin hemp. Unlike THC, which is responsible for marijuana’s psychoactive effect, CBD is not mind-altering or toxic." Read more: https://www.thealternativedaily.com/hemp-can-help-anxious-pets/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5680) CBD Oil Is the 'Wellness Vitamin' Everyone Can Benefit From, Experts Say
Date:
July 22, 2018 11:53 AM
Unlike its cousin marijuana, which is psychoactive in nature, the hemp plant has very minute amounts of the intoxicant found in marijuana. It's therefore legal to consume and sell in all of the fifty states, as long as the sellers can show their product has less than .03% of THC, the intoxicating element in marijuana. CBD oil, or cannabidiol, which is a hemp extract, is not just legal it's sexy and offered to eager consumers in pills, powders, liquids, even smoothies. CBD popularity undoubtedly arises from the fact that the hemp variant has many of the calming feel-good effects of the marijuana variant, but without the intoxicant. Besides its mood-elevating and tranquilizing effects, CBD also has been shown to help pain-sufferers and lower inflammation. Many nutrition gurus are advocating use of the oil as a daily wellness regiment. Meanwhile, product uses multiply in everything from salad dressing to chocolate. Key Takeaways:
"Currently, CBD is being added to everything from smoothie powders, coffee, tinctures, gummies and tablets to salad dressing. Despite its lack of psychoactive components, which is typically credited for cannabis’ feel-good benefits, when taken internally, CBD has a similar effect — just without the high." Read more: https://www.usmagazine.com/celebrity-body/news/cbd-oil-the-wellness-benefits-explained-by-experts/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5671) Edible or poisonous? Tips on how to determine which wild plants are safe to consume
Date:
June 30, 2018 05:54 PM
If you're an avid nature lover, it is important to familiarize yourself with which plants and flowers can be potentially toxic to you and your family's health. A good rule of thumb is to always be on the lookout for white, flowered buds. They typically appear in groups, and they indicate that the plant is either a Cicuta or a Conium plant. Both are known to be super toxic to human health, and should be avoided at all costs. Key Takeaways:
"If you find yourself forced to survive in the woods, it is important to know which plants are safe to forage." Read more: https://www.naturalnews.com/2018-06-28-tips-on-how-to-determine-which-wild-plants-are-safe-to-consume.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5651) Three nutrient dense superfoods that are easy on your digestion
Date:
June 23, 2018 05:54 PM
Eating wholesome, unprocessed, nutritious “superfoods” can help promote better health and compensate for some of the other obstacles we encounter in trying to improve our diets. Moringa, for example, provides dense leaves rich in 90 vitamins, 18 amino acids and a variety of antioxidants, and is usually prepared as a fine powder that can be added to beverages. Aloe Vera is also rich in a wide variety of nutrients, including some rare ones, and freeze dried extracts of Aloe Vera can provide an excellent source of this remarkable superfood. Perhaps most promising of all is chlorella, an algae and one of the most nutritious foods in the world. The cracked cell wall and fermented variants of this rich protein source are especially easy to digest. Key Takeaways:
"From toxic onslaughts to poor food choices, the amount of trip wires on the road to good health can be nauseating and can paralyze people into doing nothing at all." Read more: https://www.naturalnews.com/2018-06-21-three-nutrient-dense-superfoods-that-are-easy-on-your-digestion.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5644) CBD oil: the cannabis supplement taking the wellness world by storm
Date:
June 22, 2018 08:10 AM
Cannabis oil, despite having proven medicinal properties, is currently illegal in many parts of the world, because it also has high levels of an intoxicating substance. The same cannot be said for cannabidiol oil, which unlike cannabis, which comes from the marijuana plant, is a derived from hemp. Cannabidiol oil, or CBD oil, affects neural receptors in a positive way, boosting brain chemicals, like serotonin, but without psychoactive elements. This makes the oil a boon for those suffering from various forms of anxiety, as well as PTSD and panic attacks. CBD oil is anti-inflammatory and it promotes REM sleep, which makes it invaluable for joint-pain relief and insomnia. CBD oil is generally sold as both a capsule and an oil-specific product. It's recommended that users start with small doses, building up slowly. 6.4 mgs 3x a day is a good amount to enhance overall health. However, to address specific concerns, up to three times that amount many be needed. Again, one should only take such a high dose after taking the time to build up to it in increments. Key Takeaways:
"Cannabidiol (CBD) oil (derived from the stems and leaves of hemp plants) is currently flying off shelves at the moment due to its wide range of purported health benefits that include better sleep and the relief of joint pain, stress and anxiety." Read more: https://www.getthegloss.com/news/cbd-oil-its-health-benefits-explained
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5639) Where in the world is cannabis legal?
Date:
June 22, 2018 08:10 AM
Cannabis, which is a marijuana-based compound, has pronounced medicinal affects, despite also have a psychotropic effect. Cannabidiol, which is hemp-based, has many of the same medicinal affects, without the intoxicant. However, cannabis is still valued by many, who consider it to be of greater benefit than its near-neighbor, cannabidiol, in some areas. Many parts of the world are reviewing their strictures currently allied against the legal use of cannabis. In the UK there is now debate as to whether it may indeed be time to look at legalizing the compound for medicinal purposes. However, Britain's governing bodies have said that should this happen it is not to be understood that legalization of marijuana for the purposes of recreation will follow. Uruguay was the first country to make the growing, marketing, supplying and use of marijuana completely legal. Canada is slated to become country number two. Key Takeaways:
"In Canada, the nation's politicians are working on legislation that would protect young people while allowing adults to use the drug recreationally." Read more: https://news.sky.com/story/where-in-the-world-is-cannabis-legal-11409787
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5638) 8 Ways To Clean With Oregano Oil
Date:
June 02, 2018 09:16 AM
Do you know how many harmful chemicals are in items that we use on a daily basis? The shampoo you use to wash your hair, the detergent that washes your clothes, and the cleaner you use to scrub your counter all contain toxic ingredients. However, you can use other things in their place. Oregano oil can kill many bugs. You can use it to clean items, as hand sanitizer, and to freshen up your damp or smelly laundry. Key Takeaways:
"Today we know that the antibacterial and antifungal properties of oregano can be attributed to phenols in the natural oil of the plant, including thymol and carvacrol." Read more: https://www.thealternativedaily.com/8-ways-to-clean-with-oregano-oil/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5624) Will CBD Oil Help Me Sleep?
Date:
May 31, 2018 05:16 PM
Insomnia affects one-third of Americans. That shows many people are not having good sleep quality. CBD oil can help in this regard. It helps you to enter and maintain the non-REM phase of sleep (the deep sleep phase) while reducing the duration of the REM phase (the light sleep phase where dreams take place). The benefits are a marked increase in overall sleep quality and reduction of symptoms of depression and anxiety. So, even if you live in a very noisy environment, CBD oil can help you get that needed sleep. But before you chose on which oil to use, you should go for one that is environmentally-friendly and not made with toxic chemicals. Check whether the manufacturer allows third party lab testing. Also, the higher the price, the higher is the quality. Key Takeaways:
"It may sound weird, but CBD is actually known to promote alertness, and thanks to that, it helps us sleep better." Read more: http://baltimorepostexaminer.com/will-cbd-oil-help-sleep/2018/05/29
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5621) What's Legal And Illegal About CBD Oil In Tennessee
Date:
March 17, 2018 10:15 AM
Several retail venues were recently closed for selling confections with an ingredient found in hemp. While hemp and marijuana both come from the cannabis plant, they are not the same. The hemp ingredient found in the confectionary product is not from an intoxicant plant, as it's lookalike, plant relative, marijuana, is known to be. Not is it illegal to sell, or buy items made with hemp in Tennessee. Some of the plant's ingredients are even getting a name as pain assuagers and sleep aids. Nonetheless, the plant's are similar loooking, easy to confuse, and still the source of legal snafus. Key Takeaways:
"Questions surrounding the closure of multiple Rutherford County businesses have continued; so NewsChannel 5 found out what is legal and illegal about CBD oil in Tennessee." Read more: https://www.newschannel5.com/news/whats-legal-and-whats-not-when-it-comes-to-cbd-oil-in-tennessee
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5554) 6 Natural Remedies To Cleanse Your Congested Colon
Date:
February 10, 2018 03:59 PM
The colon is part of the digestive system whose function is to assimilate the nutrients of food, however, due to poor eating habits, this organ houses a large amount of toxic material that eventually wears it and generates health consequences; In this sense it is very important to consider healthy practices to improve the functioning and restore the health of this vital organ, such as drinking between 10 and 12 glasses of water and if it has a high level of alkalinity, excellent; the consumption of seeds of linanza provides a high content of fiber and omega3, the juice of lemon contributes with its detoxification and the consumption of plums helps its mobility. Finally these simple habits, can improve the health and life of your colon . Key Takeaways:
"It just so happens that one of the most effective ways to cleanse and detoxify your colon is also one of the easiest: drink more water!" Read more: https://www.thealternativedaily.com/6-natural-remedies-cleanse-congested-colon/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5525) Worried about your liver after taking Tylenol? Take Moringa peregrina – it has been found to help mitigate the effects of liver toxicity caused by the drug
Date:
January 18, 2018 03:59 PM
Tylenol may have negative effects on the liver if taken incorrectly. There are alternatives for patients that are worried about their liver. Moringa peregrina is the right choice and could save many lives out there. That medication could minimize the effects of liver toxicity over time. That includes liver toxicity caused by Tylenol and similar drugs in the class. Research has shown that approach to be effective overall. Patients were able to recover quickly on that medication. Key Takeaways:
"A team of investigators discovered that Moringa peregrina leaf extract can improve the state of livers damaged by acetaminophen, a pain reliever and fever reducer that goes by such names as Tylenol and Actamin." Read more: https://www.naturalnews.com/2018-01-17-worried-about-your-liver-after-taking-tylenol-drink-moringa-tea.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5494) Help mitigate the toxic effects of traditional cancer treatments with diet: Soy, cruciferous vegetables associated with fewer side effects
Date:
January 04, 2018 07:59 AM
Food may be a great way to help you fight cancer. A recent study has shown that eating more cruciferous vegetables, like broccoli and kale, as well as soy can help breast cancer survivors as well as menopause sufferers. The study found that the symptoms of both were decreased with a diet higher in these nutrients. Oddly they only found this with in Caucasians. Asian women were shown to have no effect from this diet, leading the researchers to have more questions about the exact pathway. Key Takeaways:
"Choosing organic soy products is the easiest way to avoid genetically modified soy." Read more: https://www.naturalnews.com/2017-12-28-help-mitigate-the-toxic-effects-of-traditional-cancer-treatments-with-diet-soy-cruciferous.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5479) WHO to DEA: You Are Completely Wrong About Marijuana
Date:
December 20, 2017 03:59 PM
The article writes about how the DEA is still classifying marijuana as bad as heroin even tho that is clearly not the case. There have been several studies on cannabidiol that prove that it has a helpful effect in curing or helping with certain illnesses such as Alzheimer's disease while also having no toxic or addictive properties. The article tries to show the DEA that their are many medically valid reasons that marijuana should be reclassified. Key Takeaways:
"In a preliminary report released by the World Health Organization (WHO) last month, a non-psychoactive substance in marijuana, cannabidiol, which the US Drug Enforcement Administration (DEA) considers to be a Schedule I drug that has no medical use and can be abused, is, in fact, not harmful, and has been shown to be a benefit to those who are ill." Read more: https://sputniknews.com/society/201712171060065986-who-to-dea-wrong-about-marijuana/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5446) 4 Easy Tricks To Remove Pesticides From Your Produce, Naturally
Date:
December 12, 2017 03:59 PM
Pesticides are needed to keep pests off of produce when it is growing, but ingesting these pesticides can be harmful to the health! Rather than risk your good health while trying to eat right, you can remove the pesticides from the produce quickly and easily, eliminating any worries. It is rather simple to remove pesticides off of your produce. Use one of these four tricks and pesticides on your produce is the least of your concerns. Key Takeaways:
"But the vast majority of Americans have no real concept of just how toxic most fruits and vegetables really are." Read more: https://www.thealternativedaily.com/4-ways-to-remove-pesticides-naturally/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5434) Scientists call on feds to allow research on CBD for pets
Date:
December 10, 2017 03:59 PM
Veterinarians, researchers and pet owners are looking to loosen federal regulations on the use of marijuana products to help treat sick animals. Medical issues in dogs, such as epilepsy, arthritis, anxiety, loss of appetite and inflammation could potentially by helped by marijuana-based drugs and extracts. Some people are already using marijuana extracts on their animals, such as those containing CBD, which is an element of marijuana that is not psychoactive. However, such extracts continue to be listed as Schedule 1 drugs by the Federal Drug Enforcement Administration, even when they contain little or no THC. THC is the active component in marijuana that causes intoxication. The Food and Drug Administration has warned that marijuana products for pets sold in animal hospitals or online pet stores are illegal, since such drugs are unapproved. The FDA has suggested it will pursue legal action against those in violation of the law. However, the policy-making body of the American Veterinary Medical Association, in conjunction with two group councils, is considering making a recommendation to the DEA for marijuana to be declassified as a Schedule 1 drug in order to enable research for both animal and human medical purposes. Declassification could also help prevent pet owners from accidentally overmedicating their animals in the absence of proper guidance from a medical professional. In September, Republican senator Orrin Hatch of Utah introduced a bill that would facilitate research on use of marijuana-based medications, concurring that the drug is over-regulated, although he continues to oppose recreational use of the drug,. Some veterinarians note that without sufficient evidence, it remains unsafe to use marijuana products on animals, with concerns about potential toxicity. Yet researchers are continuing to wait for clearance to proceed on various relevant studies, such as use of marijuana for dogs with osteoarthritis, pruritis and epilepsy. Some research on use of products with CBD has been stopped until federal approval is granted. Gaining approval has been difficult due to government requirements, which continue to be an obstacle to moving forward. Key Takeaways:
"The concern our membership has is worry about people extrapolating their own dosages, looking to medicate their pets outside the realm of the medical professional" Read more: https://www.aspentimes.com/news/scientists-call-on-feds-to-allow-research-on-cbd-for-pets/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5432) What Are The Health Benefits Of Hemp? You Can Use It In Food, On Your Skin, & So Much More
Date:
November 23, 2017 07:59 AM
Though hemp is often associated with a cannabis induced high, the truth is far different. Hemp contains only a small percentage(.03%) of cannabis and does not create a high. So what good is hemp? Hemp can be used as a stress reliever, as hair or skin products, food or even clothing and textile products. While there is still ongoing research and certifications going on, in the United States and abroad, the practical uses of hemp look promising. Key Takeaways:
"Reasons hemp is all the rage include its reported ability to reduce anxiety, sooth aches, manage chronic pain, relieve PMS symptoms, moisturize skin, and more — all without the worry of exposing yourself to toxic chemicals." Read more: https://www.bustle.com/p/what-are-the-health-benefits-of-hemp-you-can-use-it-in-food-on-your-skin-so-much-more-35415
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5411) Weeding through marijuana: Experts, advocates talk cannabidiol (CBD)
Date:
October 26, 2017 01:14 PM
Cannabidiol is a chemical compound in marijuana that helps deal with a variety of ailments such as pain, swelling, anxiety, and depression. Unlike its more famous chemical compound THC, cannabidiol doesn't give you the sensation of feeling high. For people skeptical of the ability of marijuana to help, they can hear stories like the one shared by Sage Pierson, who started taking a mix of cannabidiol to put in her tea every morning. This drastically reduced the swelling she had as a result of her arthritis, helping her live a normal life. While doctors and government officials debate the merits of CBD, it is not officially endorsed by the FDA, so you won't be able to buy it at a pharmacy near you. Key Takeaways:
"Whenever a medicated herb can provide relief to a medical condition or illness it should not only be allowed, it should be encouraged before taking (Food and Drug Administration)-approved drugs with their long list of toxic side effects." Read more: http://www.aspentimes.com/news/weeding-through-marijuana-experts-advocates-talk-cannabidiol-cbd/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5372) Is Fluoride Bad for You? It’s Not Just in the Water
Date:
October 19, 2017 10:14 AM
The benefits and risks of fluoride has been a subject of much contention since the 1960’s when it was added to the public water supply in the US and several other countries, though no studies have been shown to prove this fact. . According to the CDC, fluoride helps prevent cavities. Those against fluoride maintain that fluoride is dangerous, and can cause damaging effects to living organisms. This claim is supported by the fact that the type of fluoride in drinking water, sodium fluoride, was considered as industrial toxic waste. Key Takeaways:
"But when we look at the studies that have been done, we found that many of these questions are unsettled and we have much less information than we should, considering how long this [fluoridation] has been going on. I think that’s why fluoridation is still being challenged so many years after it began. In the face of ignorance, controversy is rampant." Read more: https://draxe.com/is-fluoride-bad-for-you/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5350) 10 Toxic skincare product ingredients to watch out for
Date:
September 26, 2017 12:14 PM
There are lots of choices in products to take care of your skin. Some are better than others, there are even ingredients that you shouldn't use on your skin. Here are some examples of things you should look for in the ingredients of your products: Certain color pigments that can cause your skin to be irritated; Hydroquinone, which can various skin diseases and even cancer; parabens can cause problems with the reproductive system; mineral oil will clog pores and keep your skin from cleaning itself out. These and other ingredients are used to make more and cheaper skincare products. Key Takeaways:
"Synthetic fragrances are considered to be one of the top allergens in beauty and skincare products." Read more: http://www.naturalnews.com/2017-09-18-10-toxic-skincare-product-ingredients-to-watch-out-for.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5282) Why this "medicine plant" is so heavily revered for optimal health
Date:
September 24, 2017 09:14 AM
Many North American physicians prescribe drugs to treat medical ailments that do not address the underlying cause of the disease and leaves patients with toxic chemicals from prescription drugs in their systems. Nature has medicinal plants that are healthier and safer. The Aloe Vera plant is a prime example of a medicine plant. The plant is packed with nutrients and disease fighting compounds. Find out here what Aloe Vera can do for you either in it's natural or supplement form. Key Takeaways:
"Since many natural health professionals proclaim that all illness begins in the gut and up to 80 percent of our immune system resides there, it makes perfect sense to use a highly medicinal plant like aloe vera to support those key functions." Read more: http://www.naturalnews.com/2017-09-14-f-why-this-medicine-plant-is-so-heavily-revered-for-optimal-health.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5276) Watch out for these nine TOXIC ingredients in your toothpaste
Date:
September 18, 2017 09:14 AM
There are nine toxic ingredients that are in toothpaste that you need to watch out for. Everyone wants to have a healthy smile and a clean one as well. It can be hard for people to achieve that though. Also, with all of the toxic ingredients that are found in toothpastes, this is an even harder thing to achieve. Aspartame is one of the toxic ingredients that people need to watch out for in their toothpaste. Key Takeaways:
"Once touted as a solution to building strong teeth, fluoride has since been exposed as a downright unsafe toothpaste ingredient with a shocking number of negative health effects." Read more: http://www.naturalnews.com/2017-09-12-watch-out-for-these-nine-toxic-ingredients-in-your-toothpaste.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5258) Cross Your Fingers—Weed Might Lower Blood Pressure
Date:
September 04, 2017 04:14 PM
The effects of CBD (Cannabidiol) are proving to be effective in lowering blood pressure in early testing. CBD is one of the main active chemicals in marijuana, but the effect in this case is not to get high, but to get calm. A company called PotBotics is using the measurement of EEGs to potentially come to a finding that it truly does reduce blood pressure. The magazine Popular Science published some recent results that in initial dosing, blood pressure DID come down. Key Takeaways:
"While the familiar high most people use weed for comes from tetrahydrocannabinol (THC), most researchers agree that CBD provides weed’s mellowing effect. It doesn’t intoxicate users, but it does calm them down." Read more: http://observer.com/2017/08/marijuana-cbd-blood-pressure/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5220) 15 Signs Your Body Desperately Needs A Detox (And What To Do)
Date:
August 22, 2017 09:14 AM
There are 15 signs that your body needs a detox. One of the signs is constant fatigue, regardless of how much sleep you get. A strange and thick coating on your tongue is another sign that your body needs a detox. If you have this sign, then your body may be in need of a serious detox. There are many other signs as well. Rapid mood swings and depression are a good indicator os a body that needs a detox. Key Takeaways:
"With your liver working overtime to process and eliminate these toxins 24/7, it’s got no time for a vacation… and we all know what happens when you don’t get that all important vacation time: a tantrum!" Read more: http://www.thealternativedaily.com/signs-your-body-desperately-needs-a-detox
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5160) The Best Natural Treatments And Medicinal Plants For Liver Detoxification
Date:
August 06, 2017 09:14 AM
There are some great natural treatments and medicinal plants for liver detoxification. The liver is a very vital organ and it detoxifies your entire body. It synthesizes proteins and removes blood waste and it is responsible for the metabolism as well as the immune system. It also is responsible for processing all sorts of toxic substances. The good news is that the liver is actually the only organ that has the ability to regenerate and can function even when it is affected in a proportion of 80 to 90 percent. Key Takeaways:
"The good news is that the liver is the only organ that has the ability to regenerate and can function even when it is affected in a proportion of 80-90%." Read more: https://www.healththoroughfare.com/medicine/best-natural-treatments-medicinal-plants-liver-detoxification/1142
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5093) Advantages And Disadvantages Of CBD Oil
Date:
July 25, 2017 12:14 PM
There are some advantages and disadvantages of CBD oil. CBD oil is a derivative of cannabis. The origin of this oil is the marijuana plant. It does not intoxicate anyone that uses it. There have been several controversies that have emerged because its parent plant is used for recreational use. But, there are many indications of the health benefits it offers. Marijuana consists of some quantity of CBD. One of the benefits of CBD oil is decreased anxiety. Key Takeaways:
"CBD oil can help in managing anxiety attacks by changing the response produced by brain receptors towards serotonin." Read more: http://reportshealthcare.com/advantages-disadvantages-cbd-oil/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5033) 10 Healthy alternatives to toxic processed table salt you can start using today
Date:
July 12, 2017 12:14 PM
Salt is generally not good for your body. White table salt especially is not good for you and has no health benefits. If you're going to use a salt try and go for a natural version. Pink salts or Sea salts are really great and even help keep your body's pH level good. The iodized table salt has a ton of chemicals in it and it's also bleached. The other natural salts have great benefits. Key Takeaways:
"Unlike commercial salts, naturally extracted salts like sea salts promote alkaline formation and help maintain a balanced body pH." Read more: http://www.naturalnews.com/2017-07-09-8-healthy-alternatives-to-your-toxic-table-salt-you-can-start-using-today.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4960) Herbs to enhance beauty
Date:
July 07, 2017 12:14 PM
A walk through the cosmetics aisle of your grocery or health food store can reveal a bewildering array of products—shampoos and conditioners, soaps, cleansers, and anti-aging face creams—promoting the benefits of the botanical ingredients they contain. But many commercial skin- and hair-care products touted as "natural" contain synthetic, potentially harmful ingredients, including preservatives and surfactants. However, it’s easy, economical, and in some cases more healthful to make herbal skin- and hair-care products in your own kitchen. By choosing herbs and ingredients recommended for specific skin types or problems, you can easily customize herbal beauty products improve the health of your skin. Key Takeaways:
"Turmeric (haldi) is a part of our traditional medicinal and beauty aids since the ancient times, due to its anti-inflammatory and antiseptic properties." Read more: http://www.thehansindia.com/posts/index/Sunday-Hans/2017-07-02/Herbs-to-enhance-beauty/309747
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4940) 5 Health Benefits Of Comfrey
Date:
July 02, 2017 12:14 PM
Comfrey, a weed common to the waters edges in Europe, has long been used as a medicinal plant. Since the Medieval period, this plant has been used as a natural remedy for a number of ailments. It has proven to be beneficial in a number areas related to healing of skin ailments, with boosts to the immune system and improved relief of inflammation. Though Comfrey does have some serious problems with toxicity due to alkaloid content. Usage of Comfrey can be done safely with positive effects. Key Takeaways:
"Researchers found that “a highly significantly and clinically relevantly faster initial reduction of wound size…was found.” They found that patients’ wounds took on average three days less to heal completely than the control group, and that there were no adverse effects or intolerability issues. It doesn’t get much better than that, folks!" Read more: http://www.thealternativedaily.com/health-benefits-of-comfrey/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4915) Drink It With A Single Blow And Your Liver Will Look Like The One You Had At 20!!
Date:
June 26, 2017 12:14 PM
The liver is the organ that suffers most from a poor diet, which is the organ that does most of the work in cleaning the bodies blood. By boiling a handful of peppermint in two liters of water, letting stand, and then straining, it can be combined with the juice from a lemon, orange, and a half tablespoon of lemon zest to create a drink that will cleanse the body and liver. If the taste is too acidic a teaspoon of honey can be added. This cleanse should be taken for a week at a cup per day. It is also recommended that the person taking this cleanse take care of their body by avoiding tobacco and alcohol while drinking two liters of water a day and eating carrots, nuts, and foods rich in fiber as well as whole grains. They should also get about eight hours of sleep to maintain a healthy system. https://www.youtube.com/watch?v=bpBH4b1Ms5w&rel=0Key Takeaways:
"While people are becoming more interested in feeling good, it is also true that we are still interested in seeing each other well."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4887) Probiotics found to protect honey bees from toxic effects of pesticides
Date:
June 25, 2017 09:14 AM
Honeybees are necessary for our agriculture they provide an air replaceable service when they cross pollinate crops. Unfortunately, the population of bees has been decreasing and human made a pesticide are a major reason. Studies conducted in fruit flies and early studies and honeybees show that a probiotic can be used to negate the effects of pesticides. Just stopping pesticide use seems a simple solution but crops could also be devastated, that's why the study into probiotics is so important. Key Takeaways:
"According to a recent study from Lawson Health Research Institute and Western University, probiotics can protect honey bees from the fatal side effects of pesticides that people use to protect their crops." Read more: http://www.naturalnews.com/2017-06-22-probiotics-found-to-protect-honey-bees-from-toxic-effects-of-pesticides.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4882) Why overall gut health is vital to wellbeing
Date:
June 08, 2017 04:14 PM
Nobody likes bloating and cramping and other gut nuisances. Millions of bacteria, also called microflora, are in gastro-intestinal tract. The state of your digestive health can effect your immunity to illnesses. A healthy digestive tract is key to overall good health. Travel, stress, diet and antibiotics can all cause problems or imbalances in the flora in the digestive tract. Probiotics help to protect the gut, as well as overall health and well-being. It's important to assure you take a probiotic that is high quality. Key Takeaways:
"Various factors such as a poor diet, high stress, travel, gastroenteritis or taking antibiotics, can cause an imbalance in the gut flora, so it is necessary for most people to supplement their diet with a high quality daily probiotic, Dicks added" Read more: http://www.iol.co.za/lifestyle/health/body/why-overall-gut-health-is-vital-to-wellbeing-9578835
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4794) Do you need a vitamin D boost?
Date:
June 05, 2017 07:14 AM
Vitamin D is good for your bones but also your immune system, blood vessels muscles strength, depression prevention and prevention of multiple sclerosis. Most people can not count on the sun providing enough vitamin D with a large amount of people not knowing they have a deficiency. Most adults should supplement with at least 10 micrograms a day, not exceeding 100 micrograms to avoid toxicity. You should definitely not try to supplement through sun exposure as it can cause skin cancer. Read more: Do you need a vitamin D boost?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4773) Learning the Health Benefits of Cannabis
Date:
June 03, 2017 04:14 PM
The cannabis debate continues to rage. Many feel it should be legalized because it can do a lot of good for the body. It is already being used medicinally in many areas. It's legal in some and illegal in others. This discusses some of the health benefits people are seeing when they use cannabis in its many forms. If you have never considered it you should check this out and you should also consider the different forms like oil, vapor and more. Key Takeaways:
"Most medical marijuana states stipulate the product has to be grown and produced and sold and consumed within that state." Read more: https://consortiumnews.com/2017/04/28/learning-the-health-benefits-of-cannabis/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4763) Only 1 Cup Of This Can Empty Your Bowel In Just 30 Minutes!!
Date:
May 26, 2017 05:14 AM
Sometimes you need to cleanse your bowels. It can rid your body of toxins. This drink can help you do this by emptying them. You only ned one cup. It works quickly as well. It's important not to do it too often, though, because you could get dehydrated and sick from it. It's something you should do rarely and if it's really necessary. You should also not do it to lose weight. Some do but that is dangerous. https://www.youtube.com/watch?v=FqHMDejR2lI&rel=0Key Takeaways:
"The following drink will help you cleanse your colon, fight constipation, and optimize health."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4695) Can CBD help dogs?
Date:
May 18, 2017 06:44 PM
THC, the active ingredient in marijuana is toxic to dogs, but CBD oil is not. Although no studies have been done on dogs, some reports claim in can help anxiety and seizures in humans. If you attempt to use CBD oil instead of doctor recommended medications, you could be putting your dog's health at risk. If you still insist on using it, start with the lowest possible dose, this can lessen the chance of a negative reaction. Read more: Can CBD help dogs?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4642) Cannabis Oil Extraction
Date:
May 18, 2017 11:44 AM
Within a marijuana plant there is an oil that can be extracted. There are a few ways to extract this oil, but one with butane or hexane could be very unsafe and harmful to the body. Healthier ways to extract this oil include olive oil. However, the oil is perishable so quick use is recommended. A carbon dioxide extraction is possible but needs a lot of equipment and a high quality of thinking. Lastly, a high grade ethanol can be used and is more common for cartridges. Key Takeaways:
"Cannabis oil made with neurotoxic solvents like butane and hexane may leave unsafe residues that compromise immune function and impede healing." Read more: https://www.projectcbd.org/cannabis-oil-extraction
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4640) One of the Best Brain Boosters, yet Hardly Anyone Does It 
Date:
May 13, 2017 11:44 AM
Dave Asprey, founder of Bulletproof.com belives that he has devised a plan that can make the brain work faster and sharper in as little as two weeks. After working long hours in silicon valley, Dave realized he was gaining weight and experiencing brain fog. He believes he experienced mitochondrial dysfunction, mitochondria fuel the cell of your body so it was like having your batteries drained. He relates you can recharge these batteries in several ways. You can use sunlight and infrared exposure, you also need quality proteins and fat to fuel your cells. There is also some biofeedback techniques that work as well. Doing all these things can get your mind and body back on track. [video mp4="//www.healthnutnews.com/one-best-brain-boosters-yet-hardly-anyone/"] Key Takeaways:
"After going on a low-fat diet, he started experiencing severe brain fog — so much so, he feared losing his career."
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The liver is a vital organ in the body that performs many essential functions. It can be damaged by a variety of factors, including disease, alcohol abuse, and exposure to toxic chemicals. Once the liver is damaged, can it be repaired? In this article, we will explore the answer to that question. We will also discuss the various ways that the liver can be damaged and how those damages can be repaired. 
