Nattokinase 1500 Fibrin Units 120 Tabs from Naturally Vitamins/Wobenzym
Nattokinase is an enzyme extracted from natto cheese, a dietary staple in Japan and believed to be the reason behind the country's record low rate of heart disease. (More information about nattokinase can be found on the Rutozym Product Page). For those seeking for a pure, potent source of nattokinase without having to travel to Asia, look no further! Nattokinase 1500 from Wobenzym USA provides a whopping 1500 fibrin units (FU) of nattokinase per serving. Unlike other similar products, Nattokinase 1500 is an enterically coated tablet. Each tablet passes through the stomach without being digested, where they are then absorbed into the blood stream via the small intestine. It is here in the blood stream where nattokinase gets to work. Other products, which get digested in the stomach, become less effective once they finally reach the bloodstream. High Purity Nattokinase from Natto Cheese (20,000 FU/gm). High potency 1500 Fibrin Unit Formula. Dietary Systemic Enzyme Supplement with Vitamin P Complex . Aspergillus niger-free. GMO-Free, No Animal Gelatin. Used in Japan for Centuries. Enterically-Coated, pH-Stable. Sucrose/Glucose-free. From the makers of Rutozym and Wobenzym - Trusted brand for more than 50 years.. Manufactured in USP-Approved facility. Easy on your wallet.
Supplement Facts :
Servings Size: 2 Tablets Servings Per Container: 60
Nattokinase providing 1,500 FU 75 mg * per serving (20,000 FU/gm)
Rutin Bioflavonoid Complex ........ 100 mg * (Vitamin P)
Other Ingredients: Plant Fiber, Modified cellulose gum, colloidal silica, vegetable magnesium stearate, vegetable stearic acid and pH-resistant Enteric Coating.
Directions:
As a dietary supplement, take two tables two times a day about 30 minutes after food. Conslult physician prior to use if taking bloodthinners or anticoagulants.
Solaray Nattokinase 100 mg (1,250 FU): Enteric-Coated Systemic Enzyme Support
Your circulatory system is a 60,000-mile highway network responsible for delivering oxygen and nutrients to every organ and tissue. Solaray Nattokinase delivers a potent, traditional fibrin-clearing enzyme derived from authentic Japanese fermented natto. Designed with an advanced enteric coating, each vegetarian capsule bypasses harsh stomach acids to release active enzymes directly into the small intestine where optimal systemic absorption takes place.
✓1,250 FU Potency: Clinically measured fibrinolytic units.
What Is Nattokinase and How Does It Work in Layman's Terms?
To understand how nattokinase works, picture your blood vessels as smooth garden hoses. When tissue is injured or irritated, your body produces a tough, fibrous protein called fibrin. Think of fibrin as microscopic spiderwebs or sticky mesh netting designed to seal leaks and form protective clots.
Under normal circumstances, your body produces its own natural "cleanup crew" enzyme called plasmin to break down and wash away excess fibrin once the job is done. However, as we age, during periods of physical stress, or with poor circulation, fibrin production can outpace our natural cleanup capacity. Left unchecked, excessive fibrin can cause blood to become sluggish, thicker, and harder for the heart to pump.
This is where Nattokinase steps in. Discovered in 1987 by Dr. Hiroyuki Sumi at Miyazaki Medical College, nattokinase is a natural protease enzyme extracted from natto—a traditional Japanese food made by fermenting non-GMO soybeans with beneficial Bacillus subtilis var. natto bacteria. Nattokinase works through a unique dual action:
Direct Action: It directly snips and breaks down excess cross-linked fibrin webs.
Indirect Amplification: It helps trigger the body's natural conversion of inactive plasminogen into active plasmin, effectively boosting your internal circulatory maintenance crew.
Viscosity Support: By keeping fibrin in check, it encourages natural blood thinning without irritating the stomach lining.
Why Enteric Coating Is Crucial for Systemic Enzymes
Many ordinary nattokinase supplements use plain vegetable or gelatin capsules that dissolve within minutes of entering the stomach. Because nattokinase is an active, delicate protein, harsh stomach hydrochloric acid (pH 1.5 to 2.0) can denature (destroy) the enzyme, turning an expensive circulatory supplement into an ordinary digested protein before it ever reaches your bloodstream.
The Solaray Enteric Advantage: Solaray utilizes a specialized pH-sensitive enteric coating on every VegCap. This shield remains completely intact against harsh stomach acid and only opens once it arrives in the alkaline environment of the small intestine (pH 6.0 to 7.4). This ensures the enzyme is absorbed into intestinal capillaries intact, allowing the full 1,250 Fibrinolytic Units (FU) to enter circulation and do its job.
Clinical Research & Scientific Evidence
Unlike generic health trends, oral nattokinase has undergone extensive clinical and pharmacological evaluation across multiple peer-reviewed trials:
1. Blood Pressure & Cardiovascular Circulation
In a randomized, double-blind, placebo-controlled trial published in Hypertension Research, 86 human subjects aged 20 to 80 with prehypertension or stage 1 hypertension received oral nattokinase daily for 8 weeks. Researchers observed statistically significant reductions in both systolic blood pressure (-5.55 mmHg) and diastolic blood pressure (-2.84 mmHg) compared to the control group.
Reference: Kim JY, Gum SN, Paik JK, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008;31(8):1583-1588. (PMID: 18971533)
2. Acute Fibrinolysis & Clot Clearance Support
A clinical crossover study published in Scientific Reports evaluated the systemic effects of a single oral dose of nattokinase in healthy human volunteers. Blood analysis demonstrated enhanced fibrin and blood clot breakdown products (such as D-dimer concentrations) and an elevation in tissue plasminogen activator (t-PA) activity within 2 to 4 hours post-ingestion.
Reference: Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601. (PMID: 26109079)
3. Arterial Plaque & Vascular Health
A comprehensive review published in Biomarker Insights highlighted nattokinase's multifaceted pharmacological benefits, including its ability to inhibit platelet aggregation, support normal endothelial elasticity, and reduce markers associated with arterial wall thickening.
Reference: Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights. 2018;13:1177271918785130. (PMID: 30013308)
Supplement Facts
Serving Size: 1 VegCap | Servings Per Container: 30
Amount Per Serving% Daily Value
Nattokinase (Soybean Fibrinase) (Supplying 1,250 FU [Fibrinolytic Units])100 mg *
!
Important Safety, Contraindications & Usage Directions
Because Nattokinase possesses genuine fibrin-dissolving properties, it is essential to observe the following medical cautions:
Prescription Blood Thinners: Do NOT use this product if you are taking prescription anticoagulant or antiplatelet medications (such as Warfarin/Coumadin, Eliquis, Xarelto, Plavix, or daily high-dose aspirin) without explicit physician supervision. Combining these may increase bleeding risk.
Bleeding Disorders: Avoid use if you have hemophilia or any active internal bleeding condition.
Upcoming Surgery: Discontinue use at least 14 days prior to any planned surgical or dental procedure.
Pregnancy & Nursing: Consult your licensed healthcare practitioner prior to use if pregnant or lactating.
Recommended Directions: Use only as directed. Adults take 1 VegCap daily with an 8 oz glass of water on an empty stomach (at least 30 minutes before a meal or 2 hours after). Taking systemic enzymes away from food ensures the enzymes target blood circulation rather than assisting in the digestion of dietary proteins. Store in a cool, dry place.
Frequently Asked Questions (FAQ)
What does "1,250 FU" mean on the Solaray Nattokinase label?
"FU" stands for Fibrinolytic Units. When evaluating enzyme supplements, milligrams (mg) only tell you how much the powder weighs, whereas FU measures its biological potency—its actual ability to break down fibrin protein. Solaray guarantees an active strength of 1,250 FU per 100 mg VegCap.
Why must Solaray Nattokinase be taken on an empty stomach?
Nattokinase is a systemic proteolytic enzyme. If taken with a meal, the enzyme expends its activity digesting proteins from your food in the digestive tract. When taken on an empty stomach (at least 30 minutes before eating or 2 hours after), the intact enzyme passes into the bloodstream to support cardiovascular circulation and vascular health.
Does Solaray Nattokinase contain Vitamin K2?
Traditional whole fermented natto contains high natural levels of Vitamin K2, which aids regular blood coagulation. Most dedicated, purified nattokinase extracts, including Solaray's enteric-coated formula, are processed to remove or isolate Vitamin K2 so the enzyme's natural fibrinolytic action remains focused and uninhibited.
Can I take Solaray Nattokinase together with prescription blood thinners?
No. You should not combine nattokinase with prescription anticoagulants or antiplatelet drugs (such as Warfarin, Eliquis, Plavix, or regular aspirin) without explicit supervision from your prescribing physician. Doing so could lead to an additive thinning effect and an increased risk of bruising or bleeding.
How long does it take for Nattokinase to work in the body?
Clinical pharmacokinetics show that systemic fibrinolytic activity begins within 2 to 4 hours following oral ingestion and remains active in the body for approximately 8 to 12 hours. For blood pressure and arterial benefits, clinical trials observe measurable results after 8 consecutive weeks of consistent daily supplementation.
FDA Disclaimer: The statements made regarding these products have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All information presented here is for educational purposes and is not a substitute for professional medical advice from a qualified healthcare practitioner.
Size: 60 CAPVEGI
S.Retail: $ 49.99
23% OFF
$ 38.49
Unlocking the Power of Nattokinase: A Natural Step Toward Heart Health
In a world where health and wellness are top priorities, it's essential to seek out natural solutions that can support our well-being. One such solution that has gained significant attention is Nattokinase, particularly the variety offered by Nature's Answer with a potency of 100 mg (2000 FU). But what exactly is Nattokinase, and how can it benefit you? Let's explore this remarkable enzyme and why it has become a popular choice for those seeking heart health support.
What is Nattokinase?
Nattokinase is an enzyme extracted from natto, a traditional Japanese dish made from fermented soybeans. Natto has been consumed for centuries for its numerous health benefits, primarily attributed to its rich content of vitamins, minerals, and enzymes. The most notable of these enzymes is Nattokinase, which has been researched for its potential effects on cardiovascular health.
How Does Nattokinase Work?
Nattokinase works by supporting the body's natural ability to dissolve fibrin—an essential protein involved in blood clotting. While clotting is a necessary process for healing, excessive clot formation can lead to health challenges, including cardiovascular issues. Nattokinase helps maintain healthy blood circulation by promoting natural fibrinolysis, the process of breaking down fibrin. This can contribute to a balanced cardiovascular system, which is essential for overall health.
The Benefits of Nattokinase
Supports Healthy Blood Flow
Maintaining healthy blood circulation is critical for overall health and vitality. Nattokinase aids in promoting proper blood flow throughout the body, which can help ensure that vital organs receive the oxygen and nutrients they need to function optimally.
Promotes Cardiovascular Health
Several studies suggest that Nattokinase may play a role in promoting heart health by maintaining normal blood viscosity. By helping to prevent excessive clot formation, this enzyme may contribute to reducing the risk of heart-related issues.
Boosts Overall Wellness
In addition to its cardiovascular benefits, Nattokinase may also support overall wellness. Many users report feeling more energetic and balanced when incorporating Nattokinase into their daily routine. With just one capsule of Nature's Answer Nattokinase 100 mg, you can take a step toward enhancing your well-being.
Why Choose Nature's Answer Nattokinase?
When selecting a supplement, quality matters. Nature's Answer is a trusted brand known for its commitment to quality and efficacy. Their Nattokinase 100 mg (2000 FU) product is carefully crafted to ensure potency and purity, giving you confidence in what you're putting into your body. Additionally, each capsule is formulated to be easy to swallow and digest, making it a convenient choice for any lifestyle.
How to Incorporate Nattokinase into Your Routine
Integrating Nature's Answer Nattokinase into your daily routine is simple. For most individuals, taking one capsule daily is sufficient to enjoy its potential benefits. However, as with any supplement, it's always wise to consult with a healthcare professional, especially if you have any existing health conditions or are taking medications.
The Importance of a Healthy Lifestyle
While Nattokinase can provide excellent support for cardiovascular health, it's essential to remember that supplements are most effective when combined with a balanced lifestyle. Incorporating regular exercise, a nutritious diet rich in fruits and vegetables, and managing stress are key components of maintaining heart health. Together with Nattokinase, these habits can help you achieve your wellness goals.
The Cardiovascular enzyme
Nattokinase is a powerful enzyme with significant potential for supporting a healthy cardiovascular system. Nature's Answer Nattokinase 100 mg (2000 FU) provides a reliable and effective option for those looking to harness the benefits of this natural enzyme. By integrating Nattokinase into your daily health regimen, you're taking proactive steps toward heart health and overall wellness.
Don't wait any longer to invest in your health! Experience the benefits of Nature's Answer Nattokinase for yourself. Click the add-to-cart button today, and take the first step towards a healthier, more vibrant life!
Nattokinase is a systemic enzyme isolated from the traditional Japanese soy food natto. It has been shown to support healthy blood flow by assisting in the circulatory clearing system of the body.
Supplement Facts
Serving Size: 2 softgels
Amount
%DV
Nattokinase
72 mg
†
Providing 1,440 fibrinolytic units (FU) of activity
Other Ingredients: soybean oil, gelatin, glycerin, beeswax, glycerin fatty acid ester, and soybean lecithin.
Warning: Do not use if you have a blood coagulation disorder. Consult your health care professional before taking this product if you are taking any drug that affects blood coagulation such as prescription vitamin K, heparin or warfarin (coumadin), or if you are pregnant or breastfeeding.
Suggested Use: 1 to 2 softgels three times daily, on an empty stomach, with 8 ounces of water.
Contains no yeast, dairy, egg, gluten, corn or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
Size: 60 softgels
S.Retail: $ 48.99
0% OFF
$ 48.99
Nattokinase 100mg is an isolated, purified and encapsulated nattokinase, which is an enzyme derived from boiled soybeans and Bacillus subtilis natto. Nattokinase is a great product that is good for healthy coagulation of blood with normal levels and enhance fibrinolytic activity.
Supplement Facts
Serving Size 1 softgel
Amount per serving:
Vitamin E (as D-alpha-Tocopherol) 10 IU
Nattokinase NSK-SD (2000 FU) 100 mg
Suggested Use:
As a dietary supplement, 1 softgel two times daily initial dose, or as directed by a healthcare practitioner. May be taken with or without food. Take with 8-10 ounces of water. If taken with anticoagulant drugs, use under medical supervision. Contraindicated in any condition associated with bleeding.
Size: 180 softgels
S.Retail: $ 118.99
0% OFF
$ 118.99
Nattokinase 100mg is an isolated, purified and encapsulated nattokinase, which is an enzyme derived from boiled soybeans and Bacillus subtilis natto. Nattokinase is a great product that is good for healthy coagulation of blood with normal levels and enhance fibrinolytic activity.
Supplement Facts
Serving Size 1 softgel
Amount per serving:
Vitamin E (as D-alpha-Tocopherol) 10 IU
Nattokinase NSK-SD (2000 FU) 100 mg
Suggested Use:
As a dietary supplement, 1 softgel two times daily initial dose, or as directed by a healthcare practitioner. May be taken with or without food. Take with 8-10 ounces of water. If taken with anticoagulant drugs, use under medical supervision. Contraindicated in any condition associated with bleeding.
The Power of Nattokinase: How This Enzyme Supports Heart Health and Circulation!
Nattokinase may be a mouthful to say, but this enzyme's potential health benefits are undeniable. Derived from a traditional Japanese food called Natto, Nattokinase has been consumed for thousands of years. In recent years, research has revealed its potential to promote healthy circulation and maintain healthy heart function. This powerful enzyme could be an essential addition to your wellness routine. Lets take a closer look into the amazing benefits of Nattokinase and how it can impact your health.
Nattokinase and Blood Clotting
One potential benefit of Nattokinase is its ability to support healthy blood clotting. Nattokinase works by breaking down the protein fibrin, which can contribute to the formation of blood clots. According to several clinical studies, including a review published in Alternative Medicine Review, Nattokinase exhibited potent anti-coagulant activity in numerous studies. This means it could help prevent blood clots from forming, potentially reducing the risk of heart attack and stroke.
Improved Circulation
In addition to its potential impact on blood clotting, Nattokinase may also support healthy circulation. Some research suggests that Nattokinase can help decrease blood pressure, reduce arterial plaque buildup, and enhance blood flow. When blood flows smoothly throughout the body, it can transport oxygen and nutrients more efficiently, supporting the health of vital organs like the heart and brain.
Potential Stroke Prevention
The health benefits of Nattokinase extend beyond just heart health. Several preliminary studies suggest that Nattokinase may also help prevent strokes. Certain types of strokes, such as ischemic strokes, are caused by blood clots that block blood flow to the brain. By reducing the risk of blood clots, Nattokinase may help lower the risk of these types of strokes. This enzyme can also thin the blood, for those who are experiencing clotting, thinner blood increases blood flow.
Dosage and Safety
Like any supplement, it's essential to take Nattokinase at the correct dosage. Research shows that doses between 50mg to 1,000mg a day of Nattokinase is considered safe. However, it's recommended that you start with small doses initially, as some individuals may experience an upset stomach. Additionally, because Natto is derived from soybeans, individuals who have soy allergies should exercise caution when taking Nattokinase supplements. This supplement can thin the blood so it is advised to consult a doctor if on blood thinners before consuming nattokinase.
In Summary: Nattokinase is a promising enzyme with numerous potential health benefits, from promoting healthy circulation to reducing the risk of blood clots and strokes. It's no wonder that it's becoming increasingly popular among the health and wellness community. With the correct dosage and a high-quality supplement like NOW's Nattokinase, incorporating this powerful enzyme into your wellness routine could be an excellent way to support overall health and vitality. As always, be sure to consult with your healthcare provider before adding any supplement while on medications.
* Item#: N3141 * Manufacturer SKU: 733739031419 * Promotes Circulatory Health* * High Potency * 2,000 FU's of Activity * Vegetarian Formula
Nattokinase is an enzyme isolated from Natto, a traditional Japanese fermented soy food. Natto has been consumed safely for thousands of years for its numerous health benefits. More recently, both clinical and non-clinical studies have demonstrated that Nattokinase supports heart health and promotes healthy circulation. Each serving of NOW® Nattokinase provides 2000 FU (Fibrinolytic Units) to help maintain already healthy levels of blood clotting factors within a healthy range.*
Nattokinase Fact Sheet
Serving Size: 1 Vcap®
Servings Per Container:
Amount Per Serving % Daily Value
Nattokinase (enzyme from Natto Extract) (soy derived) 100 mg*
(providing 2,000 FU's of enzyme activity - an assay equivalent to 160 IU Urokinase assay)
* Percent Daily Values are based on 2,000 calorie diet.
† Daily Value not established.
Suggested Usage: As a dietary supplement take 1 Vcap® 1 to 2 times daily on an empty stomach. Consider taking this product in combination with NOW® CoQ10, Tru-E BioComplex™ and Fish or Flax Oil.
Other Ingredients: Cellulose, Cellulose (capsule), Maltodextrin, Stearic Acid (vegetable source) and Silica. Contains soy derivative.
Contains no: sugar, salt, yeast, wheat, gluten, milk, egg, shellfish or preservatives. Contains noVitamin K. Vegetarian/Vegan Product.
Caution: Those with blood coagulation disorders or those currently taking any anti-coagulant (blood-thinning) medications, please consult a health practitioner prior to use.
Disclaimers: *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Introducing NOW Foods Nattokinase, a remarkable supplement designed explicitly for those seeking a natural and potent aid for their cardiovascular health. Cast from the rich history of traditional Japanese food culture, our product reflects thousand-year old wisdom combined with modern scientific interpretation.
Nattokinase, the star ingredient in our supplement, is an enzyme sourced from natto, a fermented soy food lauded for its numerous health benefits. From ancient Japanese cuisine to your modern-day health routine, this powerful enzyme has stood the test of time, continually serving humanity with its profound health-promoting properties. In recent years, both clinical and non-clinical studies have demonstrated its undoubtable potential to support heart and circulatory health by supporting normal blood clotting functions.
What sets NOW Foods Nattokinase apart? We've encapsulated this enzymatic power in a way that's both potent and convenient. The product is derived from non-GMO soy, ensuring you're getting the best of nature without any compromise. Each 100 mg serving delivers 2,000 FUs (Fibrinolytic Units), for a powerful impact on your cardiovascular health.
Quality: We only use non-GMO soy, ensuring the purity of our product and your peace of mind.
Potency: With 2,000 FUs per 100 mg serving, our Nattokinase supplement is designed for optimal efficiency.
Heritage: Our product is steeped in the rich tradition of Japanese health wisdom, offering a time-tested solution to modern health concerns.
Health: NOW Foods Nattokinase promotes heart and circulatory health by supporting normal blood clotting functions, an essential aspect of cardiovascular well-being.
Don't miss the chance to elevate your cardiovascular health with NOW Foods Nattokinase. Join the ranks of those who have experienced the transformative power of this ancient Japanese wonder and have since lived healthier, fuller lives. Act now, and make the first step towards a healthier heart. Click Add to Cart and start your journey towards better cardiovascular health today!
Supplement Facts
Serving Size:
1 Veg Capsule
Servings Per Container:
60
Description
Amount per Serving
% Daily Value
Nattokinase (2,000 FU)(enzyme from Natto Extract) (Non-GMO soy derived)
100 mg
** Daily Value not established.
**Daily Value not established.
Other Ingredients: Microcrystalline Cellulose, Hypromellose (cellulose capsule), Stearic Acid (vegetable source) and Silicon Dioxide.
Contains soy.
Not manufactured with wheat, gluten, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Caution: For adults only. Do not use if pregnant or nursing, taking “blood thinning” medications (anticoagulants) (such as aspirin, warfarin, heparin), or if you have any ongoing bleeding/coagulation problems (including but not limited to: active ulcer, recent surgery/trauma, hemophilia). Consult physician if you have a medical condition (including uncontrolled high blood pressure [equal to or higher than 200 mmHg/110 mmHg]). Keep out of reach of children.
Contains no Vitamin K.
Natural color variation may occur in this product.
Made and quality tested in the USA with globally sourced ingredients.
Size: 30ct - 2000 Fibrinolytic Units
S.Retail: $ 26.09
40% OFF
$ 15.65
Kal Nattokinase 100mg: Your Natural Solution to Blood Clot and Blood Pressure Problems
Kal Nattokinase 100mg is a remarkable supplement that leverages the power of nattokinase, an enzyme derived from a traditional Japanese food, natto. As a staple food in Japan for over a thousand years, nattokinase has been celebrated for its profound benefits in cardiovascular health. This supplement is the culmination of centuries of traditional wisdom and modern science, designed to support your body's natural ability to dissolve blood clots and regulate blood pressure.
Nattokinase works in harmony with your body's circulatory system. Its primary function is to dissolve fibrin, the protein responsible for the formation of blood clots. By doing so, it aids in keeping your blood flow unhindered and your blood pressure in check. This enzyme even extends its benefits to thin the blood, promoting overall cardiovascular health and reducing the risk of heart attacks and strokes.
Our customers seek out Kal Nattokinase 100mg for its multifaceted benefits. Whether you are looking to naturally dissolve blood clots, regulate blood pressure, or simply improve your cardiovascular health, this supplement has you covered. It's an invaluable ally for those hoping to maintain a healthy lifestyle without resorting to synthetic medications.
Natural & Effective: Kal Nattokinase 100mg utilizes the natural enzyme derived from natto, making it a natural alternative to synthetic drugs. It's effectiveness in dissolving fibrin and blood clots has been scientifically proven.
Cardiovascular Support: Regular use of this supplement can help regulate blood pressure and improve overall cardiovascular health.
Safe to Use: Kal Nattokinase 100mg is non-GMO, vegan-friendly, and free of harmful additives, making it safe for regular consumption.
Nattokinase, also known as Soybean Fibrinase, is usually measured in fibrinolytic units (FU). These units indicate the enzyme's ability to break down fibrin, a protein involved in blood clotting. The term "fibrinolytic" actually stems from "fibrinolysis," a process where fibrin is broken down, hence maintaining a balance of clotting and clot dissolution in our bodies. When the product label of Kal Nattokinase 100mg mentions "Supplying 2000 FU [Fibrinolytic Units]", it indicates the level of enzymatic activity that the nattokinase supplement provides in breaking down fibrin. In other words, a dosage of 2000 FU would have a potent effect on fibrinolysis, thus promoting healthy blood flow and cardiovascular health.
Enteric Coating:
Enhanced Stability: Enteric coating protects nattokinase from being destroyed by the acidic environment of the stomach. This ensures the enzyme reaches the intestines intact, where it can be properly absorbed.
Optimized Effectiveness: By preserving the integrity of the nattokinase enzyme until it reaches the intestines, enteric coating optimizes the supplement's effectiveness in promoting fibrinolysis and maintaining cardiovascular health.
Delayed Release: Enteric coatings delay the release of nattokinase, allowing the supplement to be distributed more evenly throughout the digestive tract for optimal absorption.
Improved Tolerance: Enteric coated supplements are less likely to cause stomach upset or discomfort, making the supplement easier to tolerate for individuals with sensitive stomachs.
Aside from its primary benefits, regular consumption of Nattokinase 100mg can also help:
Improve circulation
Enhance heart health
Reduce the risk of heart disease
Are you tired of worrying about your heart health? Do you want a natural remedy that works with your body to promote cardiovascular well-being? Choose Kal Nattokinase 100mg. With its proven history and natural formulation, it's a choice that your heart will thank you for. So why wait? Start your journey towards better heart health today with Kal Nattokinase 100mg!
WARNING: Do not use if safety seal is broken or missing. Keep out of reach of children. Keep your licensed health care practitioner informed when using this product. Do not use this product if you are taking anticoagulant (blood thinning) medications or have any condition associated with bleeding.
DIRECTIONS: Use only as directed. Take 1 tablet daily with a meal or glass of water. Store in a cool, dry place.
Supplement Facts Serving Size: 1 Tablet
Amount Per Serving
% Daily Value
Nattokinase (Soybean Fibrinase) (Supplying 2000 FU [Fibrinolytic Units])
100 mg
*
* Daily Value not established.
Other Ingredients: Cellulose, Silica, Glyceryl Triacetate and Stearic Acid.
Looking to keep your blood flowing smoothly and give your cardiovascular system targeted support? Source Naturals Nattokinase 100 mg delivers 2,000 Fibrin Units (FU) of pure, clinically validated NSK-SD®—the world's most researched form of nattokinase. Derived from traditional Japanese fermented soybeans (natto), this specialized systemic enzyme helps your body maintain healthy blood viscosity, vascular elasticity, and microvascular flow without unnecessary additives.
Quick Product Highlights
✓Clinically Active Dose: Delivers 100 mg (2,000 Fibrin Units) of patented NSK-SD® nattokinase per single-capsule serving.
✓Circulatory Clearing Power: Assists the body's natural fibrinolytic (clot-dissolving) processes to encourage effortless arterial blood flow.
✓Patented Vitamin K2 Removal: Carefully filtered using a proprietary process to remove virtually all Vitamin K2, preventing unwanted interactions with blood-thinning balance.
✓Systemic Protection: Works throughout your entire vascular tree—from major arteries down to delicate microcapillaries in the extremities, brain, and eyes.
✓Pure & Clean: Free of yeast, gluten, wheat, dairy, eggs, artificial colors, artificial flavors, and preservatives.
How Nattokinase Works: The Science of Blood Flow in Plain English
To understand why nattokinase is such a breakthrough nutrient, think of your vascular system like a vast network of highways. Throughout your life, your body relies on an insoluble protein called fibrin. When you get a cut or scrape, fibrin forms a sticky, web-like mesh that traps platelets to create a protective scab—a vital survival mechanism.
However, as we age, encounter chronic stress, or deal with low physical activity, the body can produce excess fibrin inside circulating blood vessels. Excess fibrin makes blood thicker, stickier, and more sluggish—much like debris cluttering the lanes of a busy freeway. This increases cardiovascular resistance, forcing your heart to work harder to pump blood through narrow capillaries.
Nattokinase is a systemic fibrinolytic enzyme, meaning it operates inside your bloodstream rather than merely breaking down food in your stomach. It performs a unique "double-action" cleanup:
Direct Action: Nattokinase directly cuts through and breaks down cross-linked fibrin protein threads, reducing sludgy blood build-up without disturbing normal, healthy clotting factors.
Indirect Action: It signals your body to increase its own clot-clearing machinery. Specifically, it stimulates the release of tissue plasminogen activator (t-PA) and boosts the conversion of inactive prourokinase into active urokinase, enhancing your natural endogenous enzyme defense.
Blood Pressure Balance: Nattokinase helps naturally inhibit angiotensin-converting enzyme (ACE) activity and balances plasma renin, easing tension across arterial walls to encourage smooth blood pressure control.
Clinically Grounded Research: What Human Studies Reveal
When choosing cardiovascular supplements, clinical evidence matters. Nattokinase is backed by dozens of peer-reviewed clinical trials investigating its safety, bioavailability, and physiological actions:
1. Rapid Clot-Dissolving and Anti-Thrombotic Action (Human Clinical Data)
In a landmark double-blind, placebo-controlled crossover study published in Scientific Reports, researchers administered a single oral dose of 2,000 FU nattokinase to healthy human volunteers. Blood samples tracked over 48 hours demonstrated that oral nattokinase significantly enhanced fibrin and blood clot breakdown products (such as D-dimer) within 6 to 8 hours post-ingestion.
Reference: Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Scientific Reports. 2015;5:11601. [PMID: 26109079]
2. Blood Pressure and Renin Activity Regulation
In an 8-week randomized, double-blind, placebo-controlled clinical trial published in Hypertension Research, 86 human subjects aged 20 to 80 with elevated blood pressure took 2,000 FU of nattokinase daily. The nattokinase group demonstrated a statistically significant reduction in both systolic blood pressure (-5.55 mmHg net) and diastolic blood pressure (-2.84 mmHg net), accompanied by a favorable decrease in plasma renin activity.
Reference: Kim JY, Gum SN, Paik JK, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertension Research. 2008;31(8):1583-1588. [PMID: 18971533]
3. Vascular Health and Cardiovascular Risk Markers
A multicenter North American randomized clinical trial published in Integrated Blood Pressure Control examined subjects taking nattokinase over 8 weeks. Researchers observed meaningful decreases in blood pressure alongside a significant reduction in von Willebrand factor (vWF)—a recognized biomarker for arterial inflammation and clotting risk.
Reference: Jensen GS, Lenninger M, Ero MP, Benson KF. Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker. Integrative Blood Pressure Control. 2016;9:95-104. [PMID: 27785095]
4. Long-Term Arterial Plaque and Lipid Management (1,062 Patients)
A large 12-month clinical study published in Frontiers in Cardiovascular Medicine evaluated 1,062 participants to observe the impact of daily nattokinase on arterial thickness. The findings showed sustained improvements in carotid artery intima-media thickness (CCA-IMT) and carotid plaque size, confirming nattokinase's safety profile over prolonged periods.
Reference: Chen H, Chen J, Zhang F, et al. Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. Frontiers in Cardiovascular Medicine. 2022;9:964977. [PMID: 36172238]
The NSK-SD® Difference: Why Source Naturals Leads in Quality
Not all nattokinase supplements are created equal. Raw natto food contains high amounts of Vitamin K2. While Vitamin K2 is wonderful for bone density, it is also the nutrient your liver uses to produce clotting factors. If you take a nattokinase product that retains raw Vitamin K2, you run the risk of blunting its blood-thinning and fibrin-clearing effectiveness.
Source Naturals solves this issue by exclusively utilizing NSK-SD® (Natural Super Kinase-Sprayed Dried), produced by the pioneer of nattokinase science, Japan Bio Science Laboratories (JBSL):
Patented Vitamin K2 Extraction: NSK-SD® uses a patented filtration method that reduces Vitamin K2 to less than 0.1 parts per million (virtually 100% Vitamin K2-free).
Standardized Enzymatic Potency: Every single capsule is standardized to deliver precisely 2,000 Fibrin Units (FU), guaranteeing reliable activity batch after batch.
Authentic Non-GMO Fermentation: Fermented exclusively with non-GMO soybeans and a proprietary strain of Bacillus subtilis var. natto.
Safety Authenticated: Recognized by the Japan NattoKinase Association (JNKA) and backed by extensive toxicological safety evaluations submitted to the U.S. FDA.
How to Take Source Naturals Nattokinase for Maximum Absorption
Because nattokinase is a protein-cleaving enzyme, when you take it is just as important as what you take:
Crucial Rule: Always take Nattokinase on an empty stomach!
If taken with meals, nattokinase will spend its enzymatic energy digesting proteins from your food (like meat, dairy, or beans) inside the stomach. When taken on an empty stomach with a full glass of water, it passes through the stomach intact and enters the small intestine, where it is absorbed systemically into the bloodstream to clean circulatory pathways.
Suggested Use: Take 1 capsule three times daily on an empty stomach with 8 ounces of water, or as directed by your healthcare professional. For daily maintenance, many individuals begin with 1 capsule (2,000 FU) daily.
Ideal Timing: Take your dose at least 30 to 45 minutes before a meal, or at least 2 hours after finishing a meal.
Bedtime Advantage: Many cardiovascular experts recommend taking one of your doses right before bed. Normal blood circulation naturally slows down while sleeping, making nighttime an optimal window for enzymatic circulatory support.
Safety Precautions, Warnings & Drug Interactions
Because nattokinase possesses potent fibrinolytic and blood-thinning properties, please review these vital health precautions before incorporating it into your routine:
Prescription Blood Thinners (Anticoagulants & Antiplatelets): Do NOT use nattokinase without strict medical supervision if you are currently taking warfarin (Coumadin®), heparin, clopidogrel (Plavix®), apixaban (Eliquis®), rivaroxaban (Xarelto®), or daily high-dose aspirin. Combining nattokinase with prescription anticoagulants can compound blood-thinning effects and increase the risk of bruising or bleeding.
Bleeding & Coagulation Disorders: Do not use if you suffer from bleeding disorders such as hemophilia, active stomach ulcers, or a history of hemorrhagic stroke.
Blood Pressure Medications: Because nattokinase helps ease arterial tension and may lower blood pressure, monitor your blood pressure closely if you take antihypertensive medications (ACE inhibitors, beta-blockers, or diuretics) to ensure readings do not drop too low.
Upcoming Surgeries & Dental Procedures: Discontinue taking nattokinase at least 14 days (2 weeks) prior to any scheduled surgery or invasive dental procedure to prevent excessive intra- or post-operative bleeding.
Pregnancy & Nursing: Do not use if you are pregnant, planning to become pregnant, or breastfeeding, as clinical safety has not been established in these populations.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always discuss supplement changes with your personal physician.
Complete Supplement Facts & Ingredients
VitaNet® believes in 100% label honesty. Below is the full nutritional panel and ingredient declaration for Source Naturals Nattokinase 100 mg (SKU: SN1885):
Supplement Facts
Serving Size: 1 Capsule Servings Per Container: 60
Amount Per Serving
% Daily Value
Nattokinase (NSK-SD®) supplying 2,000 Fibrin Units (FU) of activity
100 mg *
* Daily Value not established.
Other Ingredients: Microcrystalline cellulose, gelatin (capsule), colloidal silicon dioxide (silica), and magnesium stearate.
Allergen Information: Contains soy.
Free From: Contains no yeast, dairy, egg, gluten, or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor, or fragrance.
Frequently Asked Questions (FAQ)
What does "2,000 FU" mean on the nattokinase label?
"FU" stands for Fibrin Units (also called Fibrinolytic Units). Unlike simple milligrams that only measure raw powder weight, FU measures actual biological activity—how effectively the enzyme dissolves fibrin protein in laboratory tests. A standard dose of 100 mg providing 2,000 FU is the exact potency benchmark established in Japanese cardiovascular research.
How is Source Naturals Nattokinase different from eating natto food?
While eating whole natto food provides natural enzymes, it has an intensely pungent, fermented smell, a sticky stringy texture, and an acquired taste. More importantly, whole natto contains exceptionally high levels of Vitamin K2, which promotes blood clotting and makes it inappropriate for individuals monitoring vitamin K intake. Source Naturals uses NSK-SD®, which delivers pure active enzyme with virtually all Vitamin K2 removed.
Why is it essential to take nattokinase on an empty stomach?
Nattokinase is a systemic proteolytic (protein-breaking) enzyme. If you take it with food, it stays in the stomach to digest proteins from your meal. Taking it on an empty stomach (at least 30 minutes before food or 2 hours after) allows it to pass into your intestines intact, where it absorbs into your circulation to clean up vascular fibrin.
Can I take nattokinase if I am already on blood thinners like Warfarin or Eliquis?
No, you should never combine nattokinase with prescription anticoagulants or antiplatelet drugs without express supervision from your physician. Because nattokinase has natural clot-clearing properties, combining it with medications like Coumadin, heparin, Plavix, or Eliquis may excessively thin the blood and elevate the risk of internal bleeding.
How long does it take for nattokinase to start working?
Clinical pharmacokinetic trials show that nattokinase begins enhancing fibrinolytic activity in the bloodstream within 2 to 4 hours, peaking between 6 and 8 hours after consumption. For long-term cardiovascular metrics such as blood pressure balance and arterial elasticity, clinical studies demonstrate optimal outcomes with consistent daily use over 8 to 12 weeks.
Do I need to stop taking nattokinase before surgery or dental work?
Yes. Because nattokinase reduces blood stickiness and helps break down fibrin clots, you should discontinue use at least 14 days before any elective surgery, dental extraction, or invasive medical procedure to allow normal clotting mechanisms to fully stabilize.
The VitaNet® Advantage: Authentic Supplements You Can Trust
When investing in your heart health, product authenticity and freshness matter. VitaNet® has supplied high-integrity dietary supplements to wellness-focused families for over three decades:
✓100% Genuine Source Naturals Products: Sourced directly through verified manufacturing chains. Never counterfeit or diluted.
✓Climate-Controlled Storage: Enzymes are sensitive to heat and moisture. Our climate-regulated warehousing protects enzymatic activity from bottling to delivery.
✓Guaranteed Freshness: High-inventory turnover ensures you receive fresh, sealed bottles with maximum shelf life.
✓Prompt & Reliable Delivery: Orders ship promptly so your wellness regimen never misses a beat.
Size: 60 capvegi
S.Retail: $ 19.99
32% OFF
$ 13.59
Healthy Origins, Nattokinase 2,000 FU's , 100 mg, 60 Vcaps
Nattokinase is a fibrinolytic enzyme which is extracted from the popular Japanese food natto. Natto is a cheese-like food that is produced by adding bacillus natto to boiled soybeans.
Suggested Use
Adults: take one (1) vegetarian capsule once or twice daily between meals, on an empty stomach, or as directed by a physician.
Supplement Facts
Serving Size: 1 Vcap
Amount Per Serving %DV
Nattokinase (Providing 2,000 fibrinolytic units of activity in Vcap) 2,000 FU (100 mg) †
† Daily Value not established.
Other Ingredients
Vegetable capsule (cellulose, water), and microcrystalline cellulose.
No sugar, salt, yeast, wheat, gluten, corn, soy, barley, fish, shellfish, nuts, tree nuts, egg and milk.
No artificial sweetener, flavors, colors or preservatives.
Warnings
Do not use if pregnant, nursing, allergic to or contraindicated to aspirin. If you are taking aspirin, blood thinning or other medication, consult your physician before using this product. Discontinue use two week prior to surgery or if stomach upset occurs.
Keep out reach of children.
Size: 180 capvegi
S.Retail: $ 54.99
32% OFF
$ 37.39
Healthy Origins, Nattokinase 2,000 FU's, 100 mg, 180 Vcaps
Nattokinase is a fibrinolytic enzyme which is extracted from the popular Japanese food natto. Natto is a cheese-like food that is produced by adding bacillus natto to boiled soybeans.
Suggested Use
Adults: take one (1) vegetarian capsule once or twice daily between meals, on an empty stomach, or as directed by a physician.
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving %DV
Nattokinase 2,000 FU's
(Providing 2,000 fibrinolytic units of activity per capsule)
100 mg †
†Daily Value (DV) not established.
Other Ingredients
Vegetable capsule (cellulose, water), microcrystalline cellulose.
No sugar, salt, yeast, wheat, gluten, corn, soy, barley, fish, shellfish, nuts, tree nuts, egg and milk.
No artificial sweetener, flavors, colors or preservatives..
Warnings
Do not use if pregnant, nursing, allergic to or contraindicated to aspirin. If you are taking aspirin, blood thinning or other medication, consult your physician before using this product. Discontinue use two week prior to surgery or if stomach upset occurs.
Keep out reach of children.
Nattokinase is a systemic enzyme isolated from the traditional Japanese soy food natto. It has been shown to support healthy blood flow by assisting in the circulatory clearing system of the body.
Supplement Facts
Serving Size: 2 softgels
Amount
%DV
Nattokinase
72 mg
†
Providing 1,440 fibrinolytic units (FU) of activity
Other Ingredients: soybean oil, gelatin, glycerin, beeswax, glycerin fatty acid ester, and soybean lecithin.
Warning: Do not use if you have a blood coagulation disorder. Consult your health care professional before taking this product if you are taking any drug that affects blood coagulation such as prescription vitamin K, heparin or warfarin (coumadin), or if you are pregnant or breastfeeding.
Suggested Use: 1 to 2 softgels three times daily, on an empty stomach, with 8 ounces of water.
Contains no yeast, dairy, egg, gluten, corn or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
Nattokinase is a systemic enzyme isolated from the traditional Japanese soy food natto. It has been shown to support healthy blood flow by assisting in the circulatory clearing system of the body.
Supplement Facts
Serving Size: 2 softgels
Amount
%DV
Nattokinase
72 mg
†
Providing 1,440 fibrinolytic units (FU) of activity
Other Ingredients: soybean oil, gelatin, glycerin, beeswax, glycerin fatty acid ester, and soybean lecithin.
Warning: Do not use if you have a blood coagulation disorder. Consult your health care professional before taking this product if you are taking any drug that affects blood coagulation such as prescription vitamin K, heparin or warfarin (coumadin), or if you are pregnant or breastfeeding.
Suggested Use: 1 to 2 softgels three times daily, on an empty stomach, with 8 ounces of water.
Contains no yeast, dairy, egg, gluten, corn or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
Nattokinase is a systemic enzyme isolated from the traditional Japanese soy food natto. It has been shown to support healthy blood flow by assisting in the circulatory clearing system of the body.
Supplement Facts
Serving Size: 2 softgels
Amount
%DV
Nattokinase
72 mg
†
Providing 1,440 fibrinolytic units (FU) of activity
Other Ingredients: soybean oil, gelatin, glycerin, beeswax, glycerin fatty acid ester, and soybean lecithin.
Warning: Do not use if you have a blood coagulation disorder. Consult your health care professional before taking this product if you are taking any drug that affects blood coagulation such as prescription vitamin K, heparin or warfarin (coumadin), or if you are pregnant or breastfeeding.
Suggested Use: 1 to 2 softgels three times daily, on an empty stomach, with 8 ounces of water.
Contains no yeast, dairy, egg, gluten, corn or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
Nattokinase is a systemic enzyme isolated from the traditional Japanese soy food natto. It has been shown to support healthy blood flow by assisting in the circulatory clearing system of the body.
Supplement Facts
Serving Size: 2 softgels
Amount
%DV
Nattokinase
72 mg
†
Providing 1,440 fibrinolytic units (FU) of activity
Other Ingredients: soybean oil, gelatin, glycerin, beeswax, glycerin fatty acid ester, and soybean lecithin.
Warning: Do not use if you have a blood coagulation disorder. Consult your health care professional before taking this product if you are taking any drug that affects blood coagulation such as prescription vitamin K, heparin or warfarin (coumadin), or if you are pregnant or breastfeeding.
Suggested Use: 1 to 2 softgels three times daily, on an empty stomach, with 8 ounces of water.
Contains no yeast, dairy, egg, gluten, corn or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
Nattokinase is a systemic enzyme isolated from the traditional Japanese soy food natto. It has been shown to support healthy blood flow by assisting in the circulatory clearing system of the body.
Supplement Facts
Serving Size: 2 softgels
Amount
%DV
Nattokinase
72 mg
†
Providing 1,440 fibrinolytic units (FU) of activity
Other Ingredients: soybean oil, gelatin, glycerin, beeswax, glycerin fatty acid ester, and soybean lecithin.
Warning: Do not use if you have a blood coagulation disorder. Consult your health care professional before taking this product if you are taking any drug that affects blood coagulation such as prescription vitamin K, heparin or warfarin (coumadin), or if you are pregnant or breastfeeding.
Suggested Use: 1 to 2 softgels three times daily, on an empty stomach, with 8 ounces of water.
Contains no yeast, dairy, egg, gluten, corn or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
Source Naturals Nattokinase 50mg (SN1823) delivers a purified, bioactive systemic enzyme isolated from traditional Japanese fermented soybean (natto). Engineered to support cardiovascular dynamics, nattokinase works systemically to assist the body's natural fibrinolytic clearing mechanisms, degrade excess cross-linked fibrin, and promote smooth, healthy blood viscosity without unnecessary synthetic fillers.
What Is Nattokinase? The Science of Fermented Fibrinolytic Enzymes
Nattokinase is a 275-amino acid alkaline serine protease with an approximate molecular weight of 27.7 kDa, derived from the fermentation of non-GMO soybeans by the probiotic bacterium Bacillus subtilis var. natto. First identified in 1980 by Dr. Hiroyuki Sumi at the University of Chicago and Miyazaki Medical College, nattokinase was discovered when fermented natto was placed onto an artificial fibrin thrombus in a Petri dish; the enzyme cleaved the clot completely within 18 hours, demonstrating a fibrin-degrading potential far exceeding other conventional enzymes (Sumi et al., 1987).
Unlike typical digestive enzymes that break down proteins inside the gastrointestinal lumen, nattokinase is a systemic enzyme. When taken on an empty stomach, it passes through the intestinal mucosal epithelium intact into the bloodstream, where it exerts direct proteolytic activity against intravascular fibrin build-up and promotes fluid shear dynamics across capillary beds.
Mechanism of Action: How Nattokinase Supports Arterial & Venous Blood Flow
The circulatory system relies on a delicate homeostatic balance between coagulation (clot formation via fibrin) and fibrinolysis (clot breakdown via plasmin). As we age, vascular endothelial inflammation, elevated stress, and sedentary lifestyles can elevate clotting proteins and suppress our natural clearing enzymes. Research confirms that Nattokinase 50mg operates through four distinct cardiovascular mechanisms:
1. Direct Cleavage of Cross-Linked Fibrin
Nattokinase directly mimics plasmin—the body's only endogenous fibrinolytic enzyme. It cleaves cross-linked fibrin strands within microscopic deposits, breaking them down into soluble fibrin degradation products (FDPs) and D-dimers without destroying essential clotting factors during minor tissue repair.
2. Cleavage of Plasminogen Activator Inhibitor-1 (PAI-1)
Plasminogen Activator Inhibitor-1 (PAI-1) acts as the primary "brake" on the body's natural clot-dissolving machinery. Elevated PAI-1 levels paralyze tissue plasminogen activator (t-PA), allowing fibrin to accumulate. Clinical studies demonstrate that nattokinase proteolytically degrades PAI-1, releasing this inhibition and allowing natural fibrinolysis to resume unimpeded (Urano et al., 2001).
3. Upregulation of Tissue Plasminogen Activator (t-PA) & Urokinase
In addition to clearing inhibitors, nattokinase stimulates vascular endothelial cells to release endogenous tissue plasminogen activator (t-PA) and facilitates the conversion of inactive pro-urokinase into active urokinase (u-PA). This triggers a self-sustaining wave of natural plasmin activation directly along the vessel lumen.
4. Reduction of Whole Blood Viscosity & Red Cell Aggregation
By breaking down excess circulating fibrinogen and preventing red blood cells from stacking into rigid chains (rouleaux formation), nattokinase lowers whole blood viscosity. Decreased vascular friction improves microvascular capillary perfusion, peripheral blood flow to extremities, and healthy arterial wall elasticity.
Potency Breakdown: Why Fibrinolytic Units (FU) Matter More Than Milligrams
When evaluating nattokinase supplements, weight (milligrams) does not dictate potency—enzymatic activity does. Enzyme potency is measured in Fibrinolytic Units (FU), which represent the enzyme's quantifiable laboratory ability to hydrolyze and dissolve a calibrated mass of fibrin substrate over time.
Standard Clinical Target: Most clinical research on cardiovascular clearance and blood pressure stabilization validates daily dosing between 2,000 FU to 4,000 FU.
Source Naturals SN1823 Formulation: Formulated with premium concentrated nattokinase, providing targeted, flexible enzyme delivery. A standard daily intake of 1 to 2 softgels up to three times daily delivers reliable, standardized fibrinolytic units (1,440 FU to 2,000+ FU per therapeutic day), allowing users to adjust their intake based on their healthcare provider's recommendations.
Vitamin K2 Removal: Whole food natto is naturally rich in Vitamin K2 (menaquinone-7), which supports clotting cascades. High-grade clinical nattokinase extracts, such as those selected by Source Naturals, undergo specialized molecular isolation to remove Vitamin K2, ensuring pure fibrinolytic action that will not conflict with baseline vascular clearing.
Clinical Research & Scientific Citations
Nattokinase has been the subject of extensive international human clinical trials, animal studies, and pharmacodynamic reviews:
Antihypertensive & Vascular Resistance Effects:
In an 8-week randomized, double-blind, placebo-controlled human clinical trial involving 86 subjects aged 20 to 80 years, daily supplementation with 2,000 FU of nattokinase resulted in a statistically significant reduction in both systolic blood pressure (-5.55 mmHg) and diastolic blood pressure (-2.84 mmHg) compared to placebo (Kim et al., 2008, Hypertension Research).
Deep Vein & Microcirculatory Flight Study:
The landmark FLIGHT trial evaluated 186 passengers on long-haul flights (7 to 8 hours) at high risk for deep vein thrombosis (DVT) and edema. Patients administered an oral enzyme combination containing nattokinase and pinokinase prior to flight demonstrated zero thrombotic events and significantly reduced lower-leg edema, whereas the placebo control group experienced 7 venous events (5 deep, 2 superficial) and measurable fluid pooling (Cesarone et al., 2003, Angiology).
Comprehensive Review on Fibrinolytic Dynamics:
A pharmacologic review published in Biomarker Insights demonstrated that nattokinase possesses potent multi-pathway activity: accelerating plasma fibrin breakdown, extending prothrombin time (PT) and activated partial thromboplastin time (APTT) within safe biological margins, and degrading vascular atherosclerotic plaques without producing hemorrhagic side effects (Weng et al., 2017).
Source Naturals adheres strictly to Good Manufacturing Practices (cGMP) and third-party laboratory verification for identity, potency, and purity.
Supplement Facts
Serving Size: 2 Softgels • Servings Per Container: 30
Active Ingredients
Amount Per Serving
% Daily Value
Nattokinase
(standardized providing ~1,440 to 2,000 Fibrinolytic Units [FU] of active systemic enzyme)
72 mg to 100 mg*
†
† Daily Value not established.
*Batch potencies may vary based on standardized FU activity assays (delivering 50mg active nattokinase equivalent per single softgel).
Complete Ingredients:
Active Ingredient: Pure Nattokinase (from fermented, non-GMO soybean extract via Bacillus subtilis var. natto).
Other Ingredients (Excipients): Soybean oil, gelatin, vegetable glycerin, purified water, beeswax, glycerin fatty acid ester, and soybean lecithin.
Allergen Declaration: Contains Soy.
Does NOT Contain: Yeast, dairy, egg, gluten, corn, wheat, starch, sugar, salt, preservatives, or artificial colors, flavors, or fragrances.
Suggested Use & Pharmacokinetic Administration
To achieve maximum systemic absorption and biological activity, nattokinase must be taken correctly:
Take on an Empty Stomach: Consume 1 to 2 softgels three times daily, at least 45 minutes before meals or 2 hours after eating, with a full 8-ounce glass of pure water.
Why the Empty Stomach Is Essential: When ingested with food, nattokinase acts as a general protease, spending its catalytic energy digesting dietary proteins in the stomach. When consumed without food, it rapidly traverses the acidic stomach environment and enters the duodenum intact, allowing full systemic absorption into plasma.
Consistent Timing: Plasma fibrinolytic activity peaks approximately 2 to 4 hours post-ingestion, with active breakdown metabolites circulating for 8 to 12 hours. Evening dosing (before bed) is frequently recommended by practitioners because nocturnal blood flow is naturally more sluggish and endogenous fibrinogen concentrations elevate overnight.
Safety Information, Contraindications & Drug Interactions
Important Medical Advisory: Nattokinase affects systemic coagulation parameters. Consult a board-certified physician before incorporating this supplement into your daily regimen, especially if you are managing chronic cardiovascular disease.
Prescription Anticoagulant / Antiplatelet Medications: Do NOT take nattokinase in conjunction with prescription blood thinners such as Warfarin (Coumadin), Heparin, Clopidogrel (Plavix), Apixaban (Eliquis), Rivaroxaban (Xarelto), or daily therapeutic Aspirin unless directly managed and monitored by a hematologist or cardiologist. Combining systemic enzymes with blood-thinning drugs can increase the risk of unexpected bruising or bleeding.
Bleeding Disorders: Contraindicated in individuals diagnosed with active peptic ulcers, hemophilia, von Willebrand disease, recent intracranial hemorrhage, or any other coagulopathy.
Pre-Operative Protocol: Discontinue use of nattokinase at least 14 days prior to any scheduled surgical or dental procedure to prevent prolonged operative bleeding times.
Pregnancy & Lactation: Do not use if you are pregnant, planning to become pregnant, or nursing, as clinical safety profiles have not been established in these populations.
Frequently Asked Questions About Nattokinase 50mg
What is the difference between Nattokinase milligrams (mg) and Fibrinolytic Units (FU)?
Milligrams (mg) measure the physical weight of the extract powder or softgel contents, whereas Fibrinolytic Units (FU) measure the enzymatic activity—specifically the enzyme's laboratory capacity to dissolve fibrin clots. A 50mg softgel that provides high enzymatic activity is more biologically potent than a 100mg supplement containing poorly standardized raw powder. Always check for standardized FU per dose.
How quickly does Nattokinase begin working in the body?
Pharmacokinetic studies show that nattokinase enters systemic circulation and increases plasma fibrinolytic activity within 2 to 4 hours after oral ingestion on an empty stomach. Its biochemical effects on blood viscosity and fibrin clearance can remain active for 8 to 12 hours. For long-term arterial flexibility and blood pressure support, clinical trials typically evaluate results after 8 to 12 weeks of daily, consistent use.
Does Source Naturals Nattokinase 50mg contain Vitamin K2?
While traditional whole fermented food natto contains substantial amounts of Vitamin K2 (menaquinone-7), purified nattokinase dietary supplements undergo specialized filtration to remove Vitamin K. This ensures that the supplement provides targeted fibrinolytic activity without providing the coagulant-promoting cofactors associated with high-dose Vitamin K intake.
Can I take Nattokinase with Serrapeptase or Lumbrokinase?
Yes, many cardiovascular and functional medicine practitioners combine nattokinase with serrapeptase for synergistic systemic enzyme benefits. Nattokinase primarily targets fibrin within the blood vessels, while serrapeptase specializes in clearing dead cellular debris and cellular swelling throughout soft tissue. However, combining nattokinase with lumbrokinase (an exceptionally potent earthworm-derived enzyme) requires professional supervision, as stacking multiple strong fibrinolytic agents significantly amplifies blood-thinning actions.
Why must Nattokinase be taken strictly on an empty stomach?
Nattokinase is an active protease. If you consume it with meals or snacks, the enzyme will spend its catalytic power digesting dietary proteins in your stomach (similar to pepsin or bromelain). When taken on an empty stomach with 8 oz of pure water (at least 45 minutes before eating or 2 hours after), the enzyme passes into the intestines undamaged and absorbs directly into your bloodstream to work on vascular circulation.
Is Source Naturals Nattokinase safe for people with soy allergies?
Because nattokinase is derived from soybeans fermented by Bacillus subtilis var. natto, and the softgel carrier contains soybean oil and soybean lecithin, this product contains soy and is not recommended for individuals with severe, IgE-mediated soy allergies.
Solaray Nattokinase and Serrapeptase (Enteric Coated) – Dual-Action Systemic Enzyme Support for Healthy Circulation and Clear Sinuses
Give your cardiovascular and respiratory systems the targeted, cellular cleanup support they deserve. Solaray Nattokinase and Serrapeptase unites two of nature’s most effective proteolytic (protein-cleaving) enzymes to break down stubborn cellular debris, maintain elastic blood vessels, and soothe congested sinus passages.
✓ 3,000 FU Active Nattokinase
✓ 60,000 Units Potent Serrapeptase
✓ Acid-Shielding Enteric Coating
✓ 100% Vegetarian & Lab Verified
How Nattokinase and Serrapeptase Work Together in Your Body
Many people know about digestive enzymes that help break down the food you eat, but systemic enzymes do something entirely different. When absorbed into your bloodstream on an empty stomach, they operate like a dedicated cleanup crew traveling through your circulatory and lymphatic pathways.
Think of your blood vessels like clear-running streams: over time, microscopic debris made of an adhesive structural protein called fibrin can build up. While fibrin is needed to stop bleeding from cuts, excess fibrin can thicken your blood, make vessel walls stiff, and trap fluid in swollen, uncomfortable tissues.
1. Nattokinase: The Arterial Sweeper
Extracted from the traditional Japanese fermented food natto, nattokinase is a natural fibrin-dissolving specialist. It specifically identifies and slices through excessive, stubborn fibrin webs inside blood vessels, encouraging smooth arterial dilation, healthy blood viscosity, and balanced blood pressure.
2. Serrapeptase: The Debris & Mucus Dissolver
Originally discovered in the digestive tract of silkworms (now cleanly cultivated via friendly bacterial fermentation), serrapeptase safely digests dead tissue, inflammatory proteins, and thick mucus without harming living cells. It is widely praised for clearing nasal pathways and soothing irritated joint tissues.
The Scientific Evidence: Verified Peer-Reviewed Clinical Research
Unlike generic supplement blends based on guesswork, both nattokinase and serrapeptase are backed by extensive human clinical trials and biochemical evaluations:
✓ Direct Carotid Plaque and Artery Support
In a 12-month clinical study involving 1,062 human participants, daily nattokinase supplementation demonstrated substantial, statistically significant reductions in both carotid plaque thickness and carotid intima-media thickness (CCA-IMT), while promoting healthier lipid balances.
Clinical Citation: Chen H, Chen J, Zhang F, et al. Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. Front Cardiovasc Med. 2022;9:964977. PMID: 36172235.
✓ Multi-Path Fibrin Dissolution & Blood Flow
Clinical evaluations demonstrate that oral nattokinase acts through multiple vascular protective pathways: it breaks down cross-linked fibrin networks directly, supports the body's natural tissue plasminogen activator (t-PA), and reduces inhibitors that cause sluggish blood flow.
Clinical Citation: Weng Y, Yao J, Sparks S, Wang KY. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017;18(3):523. PMID: 28264497.
✓ Respiratory Secretion Breakdown & Sinus Comfort
Double-blind, placebo-controlled human trials show that serrapeptase (serratiopeptidase) thins dense nasal and bronchial mucus, allowing the respiratory system to flush out congested fluids quickly and restoring easy, unobstructed airflow through the sinuses.
Clinical Citation: Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990;18(5):379-388. PMID: 2258169.
Why Enteric Coating Is Essential for Enzyme Potency
Many ordinary enzyme supplements fail before they ever get the chance to work. Your stomach relies on strong digestive acid (pH 1.5 to 3.5) to dissolve protein. If delicate systemic enzymes like serrapeptase and nattokinase are unprotected, that harsh acid will destroy them, breaking them down into inactive amino acids.
How Solaray Protects Every Single VegCap:
Acid Armor: The specialized enteric capsule coating remains completely intact as it passes through the corrosive environment of your stomach.
Intestinal Release: Once the capsule reaches the neutral, slightly alkaline pH (6.8 to 7.4) of your small intestine, the coating gently dissolves.
Direct Absorption: Both enzymes enter your bloodstream in their full biological forms, delivering their active 3,000 FU and 60,000 units directly to your circulation.
Complete Supplement Facts & Ingredient Breakdown
Solaray manufactures each batch under strict cGMP pharmaceutical standards, with every lot tested by independent third-party laboratories for purity and potency.
Supplement Facts
Serving Size: 1 VegCap | Servings Per Container: 30
Amount Per Serving% Daily Value
Nattokinase (Soybean Fibrinase) (Supplying 3,000 FU [Fibrinolytic Units])150 mg *
Serrapeptase (Supplying 60,000 Units [2,000 U/mg])30 mg *
Allergen Notice: Contains soy. Free from artificial flavorings, synthetic preservatives, and animal gelatin. 100% Vegan formula.
How to Take for Maximum Results & Safety Precautions
Directions for Daily Use:
Take one (1) VegCap daily on an empty stomach with an 8-ounce glass of water. For best results, take it at least 60 minutes before your morning meal or two hours after eating. Taking systemic enzymes with food causes them to digest your food instead of working systemically inside your bloodstream.
Important afety & Medical Precautions:
Blood Thinners: Do NOT use this product without your doctor's supervision if you take anticoagulant or antiplatelet drugs (e.g., Warfarin, Coumadin, Eliquis, Plavix, Xarelto), or daily high-dose aspirin.
Upcoming Surgery: Discontinue use at least 14 days before any surgical or dental procedure to avoid prolonged bleeding times.
Bleeding Disorders: Do not take if you have a history of bleeding conditions, ulcers, or active internal lesions.
Pregnancy & Nursing: Consult a physician prior to use if pregnant or nursing, as human safety trials are currently limited.
Frequently Asked Questions (FAQ)
What is the difference between Nattokinase and Serrapeptase?
While both are protein-cleaving systemic enzymes, they specialize in different areas. Nattokinase primarily focuses on cardiovascular health by clearing away excess fibrin webs in blood vessels, preventing thick sluggish blood, and maintaining arterial elasticity. Serrapeptase is broader, specializing in clearing dead cellular debris, soothing joint irritation, and liquefying dense mucous fluids in congested sinuses and airways.
Why must I take Nattokinase and Serrapeptase on an empty stomach?
If you consume these enzymes with food, they will immediately begin breaking down the proteins in your meal, acting as digestive aids. To support your cardiovascular, circulatory, and sinus health, the enzymes must remain unattached so they can pass into your small intestine, absorb directly into your bloodstream, and circulate throughout your body.
What does FU mean on a nattokinase supplement label?
"FU" stands for Fibrinolytic Units. It is an internationally recognized scientific measurement of the enzyme's active potency — specifically its ability to dissolve fibrin. Milligrams (mg) only tell you the physical weight of the powder in the capsule, whereas FU verifies how active and effective the enzyme is. Solaray provides 3,000 FU per serving, surpassing standard 2,000 FU formulas.
Can I take Nattokinase and Serrapeptase with prescription blood thinners?
No, not unless you are under the direct supervision of your physician or cardiologist. Because nattokinase naturally thins and clears circulatory pathways, taking it alongside medications like warfarin, Eliquis, Plavix, or high-dose aspirin can increase your chance of bleeding or bruising.
How quickly will I notice the benefits of Nattokinase and Serrapeptase?
For sinus drainage and clearer nasal airways, many people notice positive changes within 3 to 7 days. For cardiovascular goals like healthy arterial flexibility, balanced blood pressure, and long-term circulatory support, clinical studies evaluate benefits over 8 to 26 weeks of consistent daily usage.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. VitaNet® LLC reminds customers that dietary supplements must be used responsibly and under the supervision of a licensed physician, especially when managing cardiovascular or circulatory health conditions.
Scientific References:
1. Sumi H, et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto. Experientia. 1987;43(10):1110-1111.
2. Chen H, et al. Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. Front Cardiovasc Med. 2022;9:964977.
3. Weng Y, et al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017;18(3):523.
4. Mazzone A, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology. J Int Med Res. 1990;18(5):379-388.
5. Tiwari M. The role of serratiopeptidase in the resolution of inflammation. Asian J Pharm Sci. 2017;12(3):209-215.
Size: 30 capsule
S.Retail: $ 42.99
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$ 31.38
Nattokinase Complex 350mg by Olympian Labs
Nattokinase is derived from fermented soybeans. Research has shown that Nattokinase may aid in maintaining natural activities of the blood. Fibrin is a protein, that when activated, forms fibrinogen which is responsible for management of healthy blood activity. OL use only the highly absorbable, proprietary extract of Nattokinase.
SUGGESTED USE
As a dietary supplement, take one (1) capsule daily on an empty stomach, or as directed by a healthcare professional.
Free Of GMO and animal ingredients.
SUPPLEMENT FACTS
Serving Size: 1 Capsule Servings per Container: 30
Those with blood coagulation disorders or those currently raking any anti-coagulant (blood-thinning) medications please consult a health practitioner prior to use. If you are pregnant or nursing, have a medical condition, or are taking medication, consult your healthcare professional before using this or any other nutritional supplement. Discontinue use if allergic reaction occurs.
