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Compound in turmeric found to suppress viruses, including hepatitis, herpes, chikungunya, influenza-A, HIV and HPV Darrell Miller 5/17/17
Ever wondered if sugar makes you hyper? Darrell Miller 12/9/16
Breast Cancer and Natural Supplements Darrell Miller 5/11/07
Super Cortisol Support Fact Sheet Darrell Miller 12/8/05
Re: Magnesium Darrell Miller 10/6/05
Stevia Sweetleaf with FOS - A Healthy Choice for Balanced Blood Sugar Levels Darrell Miller 6/6/05
Re: Its in the Blood Darrell Miller 5/9/05




Compound in turmeric found to suppress viruses, including hepatitis, herpes, chikungunya, influenza-A, HIV and HPV
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Date: May 17, 2017 03:44 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Compound in turmeric found to suppress viruses, including hepatitis, herpes, chikungunya, influenza-A, HIV and HPV





Recent studies on curcumin, a compound found in turmeric, in addition to treating cancer, diabetes and Alzheimer's can also be effective against several concerning viruses. Cur cumin affects the ability of many viruses to infect healthy cells in the body, causing damage. Positive results have come from several viral studies including hepatitis, HPV, Zika , and even HIV among other viruses. Further research is necessary but turmeric has so far shown that it useful and should be taken medicinally.

Key Takeaways:

  • Curcumin, a substance found in turmeric, has recently been shown to decrease the ability of Hepatitis C to infect cells.
  • A turmeric-derived compound called curcumin may be a potent tool in the fight against Zika.
  • Curcumin may help combat sexually transmitted diseases such as HPV and herpes, because it impairs the ability of the viruses to spread to new cells.

"According to a team of researchers from the Pasteur Institute in France, the turmeric compound not only inhibited the growth of zika and chikungunya viruses, but also halted the ability of these harmful viruses to infect otherwise healthy cells."

Read more: http://www.naturalnews.com/2017-05-11-compound-in-turmeric-found-to-suppress-a-number-of-significant-viruses-including-hepatitis-herpes-chikungunya-virus-influenza-a-hiv-and-hpv.html

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Ever wondered if sugar makes you hyper?
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Date: December 09, 2016 12:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Ever wondered if sugar makes you hyper?





Many parents think sugar makes kids hyper. No one, not the kids, the parents or the doctors knows which kids got which diet. A special code is used so the results can be evaluated after the study is completed. If sugar doesn't make kids hyper, why do parents believe it does? If kids eat too much sugar, they may reject healthful foods as not being sweet enough. As a result, you may not be aware of how much sugar is in your diet. Many popular brands of yogurt contain 20 grams or more of added sugar.

Key Takeaways:

  • Lots of scientific studies have been done to answer the question, and they have all reported the same thing: Sugar does not make kids overactive.
  • Doctors take a bunch of kids who are similar in age, background and other factors.
  • Sugar tastes good but has no nutritional value. That means it doesn't help you grow or stay healthy. Too much sugar can change the way you think food should taste.

"I love goofing around with my patients. I often start visits with younger kids by asking for a foot rub. I do this to make visits more fun (and less scary) and to give my patients "permission" to act silly."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//www.omaha.com/livewellnebraska/nutrition/ever-wondered-if-sugar-makes-you-hyper/article_9e8b149e-b0d5-11e6-afc1-8f2ba5929ca0.html&ct=ga&cd=CAIyGjY3NzEzYzg1MjE0ZjUwYzU6Y29tOmVuOlVT&usg=AFQjCNHyI8hOkbxO4KyRTEnx-J3Fy9jNkg

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Breast Cancer and Natural Supplements
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Date: May 11, 2007 10:47 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Breast Cancer and Natural Supplements

Breast Cancer and Nutritional Supplements

 

There is probably nothing more frightening for a woman than the discovery of a lump in her breast. Cancer and all its consequences quickly come to mind. This quick association may materialize, in part, because no woman is immune. Most have a friend, a sister, a mother, or a coworker who has been diagnosed with the disease. And they know how difficult dealing with this disease can be. Fortunately, 80% of all breast lumps are not cancerous. Most are cysts or a benign clump of tissue.

Over her lifetime, a woman’s breasts undergo many, many changes. From before puberty and on, breast tissue is continually evolving. Breasts often feel different before menstrual cycle, returning to normal a few days after. Pregnancy certainly causes changes in a woman’s breasts, as does breastfeeding. And as women age, breast tissue becomes less dense.

Because of these continual changes, breast tissue especially requires adequate nutrition. While everyone benefits from a healthy diet, there are additional nutrients from which women can specifically benefit.

In this issue of Ask the Doctor, we will discuss breast cancer and the vast amount of research that has explored the role nutrition plays in this serious and still deadly disease. Specifically, we will discuss how two B vitamins, calcium D-glucarate, broccoli extract, green tea, maitake mushrooms, and iodine can all help prevent breast cancer.

 

Q. How can these nutrients prevent breast cancer?

A. Scientists learn a lot about disease from simply observing what is happening around them. One observation that has been recognized for many years is that certain cultures have very low incidence of breast cancer. Women n China and Japan are good examples of this. Compared to women in America, Canada, and parts of Europe, Asian cultures have much lower breast cancer rates. It seems likely that something in their diet might be protecting these women from the disease because once Asian women adopt a western diet, their breast cancer rates climb.

Moms (and dads) have also learned a lot about diseases simply by observing what is happening in their families. They have notices that certain vegetables play a large role in the prevention of all types of diseases, including cancer. And, accordingly, they have been urging their offspring to eat their vegetables for several generations.

Building on these observations, scientists have designed and carried out many studies to determine what it is about these nutrients that can prevent breast cancer. What they have discovered, so far, follows. Let’s start with the B vitamins.

 

Vitamin B12

Deficiencies of this vitamin can result in a serious type of anemia. Nerve damage can also occur if B12 levels are too low. Researchers are now investigating whether breast cancer may, in part, be caused by a B12 deficiency as well.

At John Hopkins University in Maryland, two large but separate blood sample donations were evaluated against cases of breast cancer. In 1974, 12,450 blood samples were donated by female volunteers. In 1989, another 14,625 women again voluntarily donated samples of their blood. Cases of breast cancer that occurred in these groups of women were then recorded and their blood samples examined. Women, who had the lowest levels of B12 in their blood, had the highest rates of breast cancer.

Another study, this one taking place in a laboratory setting, discovered that vitamin B12, applied directly against experimental breast cancer cells, actually stopped the cancer cells from growing. The researchers conducting the experiment believe that giving vitamin B12 to women with breast cancer as part of a chemotherapy regime, might help keep the cancer in check.

 

Folic Acid

Low folic acid intake is linked to the development of all cancers. This is because folic acid is crucial to the making and continual repair of DNA, the molecule that carries our genetic code. A recent study discovered that high intakes of folic acid might actually reduce the risk of breast cancer. The researchers looked at the diets of over 2600 women. During interviews with the researchers, the women reported what they usually ate. Once the data was collected, the results showed that women, who ate lots of foods that contained folic acid, had much lower rates of breast cancer.

There is no clear-cut, single cause of breast cancer. Many factors are required for the disease to appear. One such factor is estrogen. A recent study showed that women who developed breast cancer tended to have higher levels of estrogen circulating in their bodies than women without breast cancer. This means that women who got their periods before age eleven or entered menopause after age fifty-five have a higher risk of breast cancer. This also supports the theory that the number of menstrual cycles a woman has affects her risk for breast cancer.

Another factor is drinking alcohol. Because alcohol raises estrogen levels, if a woman consumes even moderate amounts of alcohol her risk of breast cancer also is increased. The link between alcohol and breast cancer may even be stronger than other dietary links. However, an important study has discovered that folic acid may uncouple this link.

A very large study of over 34,000 women recently studied the effect of folic acid on the risk of breast cancer. This project was part of the Nurses’ Health Study, an ongoing, long-term study that looks at nutrition’s role in the development of disease. The women in the folic acid and breast cancer study were followed for 12 years. The participants completed detailed food questionnaires that provided the researchers with important data.

The women were divided into four groups:

1.      Women with low folic acid levels and drink alcohol

2.      Women with high folic acid levels and rink alcohol

3.      Women with low folic acid levels and don’t drink alcohol

4.      Women with high folic acid levels and don’t drink alcohol

Within these four groups the women were further divided into subgroups according to the amount of alcohol they consumed each day and their specific folic acid intake.

The researchers found that women who consumed the lowest amounts of folic acid and drank at least one alcoholic beverage a day had the highest rate of breast cancer. In contrast, women who had high intakes of folic acid and also drank at least one alcoholic beverage a day, had the same rate of breast cancer as the women with high folic acid intakes who did not drink. In other words, women who had high levels of folic acid in their diet erased their alcohol-related increase in breast cancer risk.

 

Calcium D-Glucarate

It seems estrogen can be both friend and foe. While women need the hormone to soften skin, thicken hair, and fill out hips and breasts, estrogen can also nourish breast tumors, helping them grow bigger, stronger, and more deadly. Thanks, in part, to good nutrition, American women get their periods early and go through menopause alter in life. Women today also have fewer pregnancies; families with one or two children are quite common.

All of these factors increase the time women’s bodies are exposed to estrogen. As we discussed before, longer exposure means increased opportunities for estrogen to cause trouble. It is also a troubling fact of modern life that we are continuously exposed to cancer-causing chemicals and toxins. These toxins come in part from contaminants in the food we eat and pollutants in the air we breathe.

The body does have a system that eliminates some of the excess estrogen and toxic chemicals before they can cause harm. In the liver, they are bound or attached to a chemical called glucuronic acid. The bound toxin or estrogen is then excreted in bile and eventually eliminated as a waste product in the stool.

However, an enzyme called beta-glucuronidase can break this bond between estrogen and glucuronic acid. When this happens, the hormone or toxin is released from its bone, capable of causing harm once more. Increased beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependant cancers like breast cancer.

Fortunately, scientists have discovered that a natural substance found in foods calcium D-glucarate (CDG) can stop the activity of beta-glucuonidase. CDG keeps the harmful estrogen bound to glucuronidase. While CDG is found in fruits and vegetables, the amounts may not be sufficient to maintain effective levels to stop beta-glucuronidase.

CDG has been shown in experimental studies to significantly stop beast cancer growth. And several human trials are currently underway with CDG to determine its capability to decrease the breast cancer risk in women at high risk for the disease.

 

Iodine

There are some very interesting connections between breast tissue and thyroid tissue. Iodine is an essential trace element present in a hormone of the thyroid gland and is involved in several metabolic functions. One iodine function is the protection of breast tissue from cancerous cells.

In a laboratory study, researchers exposed breast cancer cells and breast tissue without any cancer to a type of seaweed that contains high levels of iodine. The seaweed killed all of the cancerous cells, yet did not harm the normal breast cells. Japanese women frequently eat this type of seaweed and have very low rates of breast cancer. The study’s researchers believe one reason for this low incidence of breast cancer may be the iodine in the seaweed.

And, for some as yet unknown reasons, women who have thyroid cancer are at higher risk of developing breast cancer. While they are unsure why this happens, researchers are continuing to study this link, and support of healthy thyroid function remains an important consideration.

 

Broccoli

For quite some time, scientists have observed that cruciferous vegetables, such as broccoli, cabbage, and cauliflower, significantly reduce the risk of disease, including cancer. It seems a phytochemical in broccoli sulforaphane, is one of the chemicals responsible for this beneficial activity. Sulforaphane increases certain enzymes in the body called phase 2 enzymes that deactivate cancer-causing chemicals.

Breast cancer cells exposed to sulforaphane in several lab experiments showed that the compound inhibited the growth of the cancer cells up to 80 percent. Researchers are in the process of setting up clinical trials to study sulforaphane’s effect in women who have breast cancer.

 

Green Tea

There is a tall amount of research, including finding from the Nurses’ Health Study, that suggest green tea beverage consumption is associated with a lower incidence of breast cancer. In fact, researchers have long noted the low rates of breast cancer in Japan, a country where green tea consumption is very high.

The active compound in green tea responsible for breast cancer inhibition is epigallocatechin-3 gallate or EGCG. When breast cancer cells are exposed to EGCG in lab experiments, the cells stop growing, lose their ability to replicate, and die.

In a recent study, researchers discovered that drinking green tea prevented the recurrence of breast cancer in women who have previously been diagnosed and treated for the disease. This study involved over 1100 Japanese women. The women who drank green tea every day had very low rates of their breast cancer returning.

 

Maitake Mushrooms

For thousands of years, maitake mushrooms have been linked to good health in those who eat them. Called “dancing mushrooms” (possibly due to their wavy, rippling appearance or possibly due to the little dance of joy mushroom hunters perform when they find them in the woods), maitakes contain an important compound called D-fraction.

Not only does the D-fraction in maitake mushrooms stop the growth of cancerous tumors, it also alerts and stimulates immune cells (including macrophages and natural killer cells) to fight the disease. Maitake also inhibits some of the mechanism that promotes metastasis, or spread, of cancer cells in the lymph and bloodstream.

Because of this success, maitake is now being used in clinical trials of women with breast cancer. One study reported significant improvement of symptoms, including reduction of the tumor. The maitake was given to breast cancer patients in addition to standard chemotherapy.

 

Q. Should these nutrients be used in place of traditional treatment for breast cancer?

A. Absolutely not. None of these nutrients can cure breast cancer. However, they can be a part of a validated plan of treatment. If you have breast cancer, talk to your health care practitioner about these nutrients. Remember, nutritional supplements are just that: supplements to food, medication, and treatment. They are intended to enhance and prevent, not replace.

 

Conclusion

Despite apprehension in performing self-breast exams, women are very proactive in their health. Yearly mammograms and pap tests have been an important part of their lives for many years, and newer and more accurate diagnoses are emerging. The prevention of health problems in themselves and their families has always been a high priority for women. And for women, nutrition has played an important part of health problem prevention.

Nutritionally speaking, what benefits your breasts benefit your whole body. However, as we have learned, there are specific links between nutrition and developing breast cancer that seem to be fairly strong.

Making a few changes may reduce the risk of developing the disease. The nutrients listed here, vitamin B12, folic acid, calcium d-glucarate, iodine, broccoli, green tea, and maitake mushrooms can be an important part of a woman’s preventative health regimen.



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Super Cortisol Support Fact Sheet
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Date: December 08, 2005 07:04 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Super Cortisol Support Fact Sheet

Super Cortisol Support Fact Sheet

Neil E. Levin, CCN, DANLA 10/1/05

LIKELY USERS: People under a lot of stress; People who suffer from stress-related eating; People who may have metabolic syndrome (Syndrome X);

KEY INGREDIENTS: Relora®13, Rhodiola14-20, Reishi 21-24, Green Tea Extract25-32, Holy Basil, Ashwaganda, Banaba, Pantothenic Acid, Calcium Ascorbate, Magnesium, Lecithin, Chromium

MAIN PRODUCT FEATURES: NOW® Super Cortisol Support is an herbal and nutritional formula designed to support healthy adrenal function and maintain healthy cortisol levels. The adrenal glands help the body respond and adjust to stress generated from both internal and external forces. Under chronic stress, cortisol can be overproduced, resulting in weight gain and difficulty in managing healthy blood sugar levels. Super Cortisol Support combines adaptogenic herbs with Chromium, Corosolic Acid and Relora® to help the body manage the negative effects of stress such as abdominal obesity, overeating and low energy levels.

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES:

Reishi, Rhodiola, Ashwaganda, and Holy Basil support healthy energy levels throughout the day1-6. Reishi, Rhodiola, Ashwaganda, and Holy Basil support healthy immunity1-9. Along with Chromium, and Corosolic Acid, these herbs also help to support healthy serum glucose levels1-12. Relora® has been included in this formula to alleviate symptoms associated with stress such as irritability and nervous tension13.

This formula is recommended by Hyla Cass, MD.

This is the first Cortisol formula to use Relora®, a natural proprietary blend of a patented (U.S. Patent No. US 6,582,735) extract of Magnolia officinalis and a patent-pending extract from Phellodendron amurense. Relora® was developed as an ingredient for dietary supplements and functional foods that could be used in stress management and for stress-related appetite control. This patented blend of plant extracts is the result of screening more than fifty plant fractions from traditional plant medicines used around the world. Relora® has excellent stress management properties without causing sedation. Overweight adults may have excessive abdominal fat due to stress-related overeating. Relora® appears to maintain healthy hormone levels in stressed individuals and act as an aid in controlling weight and stress-related eating.33

SERVING SIZE & HOW TO TAKE IT: One capsule, two to three times a day.

COMPLEMENTARY PRODUCTS: Holy Basil, Green Tea, L-Theanine, Licorice Root, Vitamin C, Eleuthero Root, Pantothenic acid

CAUTIONS: None.

SPECIFIC: Some of these ingredients may support the body’s blood sugar controls, so people taking blood sugar medications should inform their physician before using Super Cortisol Support, and their glucose should be monitored when taking this formula so their medication strength can be modulated appropriately to avoid an overdose of medication. No side effects have been noted for this dosage of Relora®.

GENERAL: Pregnant and lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV (2000) Phytomedicine 7(2):85-89.
2. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H (2000) Phytomedicine 7(5):365-371.
3. Bhattacharya SK, Battacharya A, Sairam K, Ghosal S (2000) Phytomedicine 7(6):463-469.
4. Sembulingam K, Sembulingam P, Namasivayam A (1997) Indian J Physiol Pharmacol 41(2):139-143.
5. Archana R, Namasivayam A (2000) J Ethnopharmacol 73:81-85.
6. Lin Z-B, Zhang H-N (2004) Acta Pharmacol Sin 25(11):1387-1395.
7. Monograph (2002) Alt Med Rev 7(5):421-423.
8. Agarwal R, Divanay S, Patki P, Patwardhan B (1999) J Ethnopharmacol 67:27-35.
9. Archana R, Namasivayam A (2000) J Ethnopharmacol 73:81-85.
10. Vincent JB (2000) J Nutr 130:715-718. 11. Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YMA, Passwater R (2003) J Ethnopharmacol 81)1):115-117.
12. Lin Z-B, Zhang H-N (2004) Acta Pharmacol Sin 25(2):191-195.
13. Maruyama Y, Kuribara H, Morita M, Yuzurihara M, Weintraub ST (1998) J Nat Prod 61:135-138.
14. Brown RP, et al. American Botanical Council. Rhodiola rosea: a phytomedicinal overview. g/herbalgram/articleview.asp?a=2333.
15. Kelly GS. Rhodiola rosea: a possible plant adaptogen. Alt Med Rev 2001;3(6):293-302.
16. De Bock K, et al. Acute rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab 2004;14:298-307.
17. Shevtsov VA, et al. A randomized trial of two different doses of a SHR-5 rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;2-3(10):95-105.
18. Shugarman AE. Men’s Fitness, 2002. As reported on: LookSmart FindArticles. Energy pills that work: can these five supplements help unleash the muscle building power within you? ttp://findarticles.com/p/articles/mi_m1608/is_3_18/ai_83343009/
19. Earnest CP, et al. Effects of a commercial herbal-based formula on exercise performance in cyclists. Med Sci Sports Exerc 2004;36(3):504-9.
20. Wing SL, et al. Lack of effect of rhodiola or oxygenated water supplementation on hypoxemia and oxidative stress. Wilderness Env Med 2003;14(1):9-16.
21. Shu HY. Oriental Materia Medica: A Concise Guide. Palos Verdes, CA: Oriental Healing Arts Press, 1986, 640–1. 22. Kammatsuse K, Kajiware N, Hayashi K. Studies on Ganoderma lucidum: I. Efficacy against hypertension and side effects. Yakugaku Zasshi 1985;105:531–3.
23. Jin H, Zhang G, Cao X, et al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Nimmi H, Xiu RJ, Sawada T, Zheng C. (eds). Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science, 1996, 131–8.
24. 9. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995, 96–107.
25. Kono S, Shinchi K, Ikeda N, et al. Green tea consumption and serum lipid profiles: A cross-sectional study in Northern Kyushu, Japan. Prev Med 1992;21:526–31.
26. Yamaguchi Y, Hayashi M, Yamazoe H, et al. Preventive effects of green tea extract on lipid abnormalities in serum, liver and aorta of mice fed an atherogenic diet. Nip Yak Zas 1991;97:329–37.
27. Sagesaka-Mitane Y, Milwa M, Okada S. Platelet aggregation inhibitors in hot water extract of green tea. Chem Pharm Bull 1990;38:790–3.
28. Stensvold I, Tverdal A, Solvoll K, et al. Tea consumption. Relationship to cholesterol, blood pressure, and coronary and total mortality. Prev Med 1992;21:546–53.
29. Tsubono Y, Tsugane S. Green tea intake in relation to serum lipid levels in middle-aged Japanese men and women. Ann Epidemiol 1997;7:280–4.
30. Serafini M, Ghiselli A, Ferro-Luzzi A. In vivo antioxidant effect of green tea in man. Eur J Clin Nutr 1996;50:28–32.
31. Benzie IF, Szeto YT, Strain JJ, Tomlinson B. Consumption of green tea causes rapid increase in plasma antioxidant power in humans. Nutr Cancer 1999;34:83–7.
32. Sasazuki S, Komdama H, Yoshimasu K, et al. Relation between green tea consumption and severity of coronary atherosclerosis among Japanese men and women. Ann Epidemiol 2000;10:401–8.
33. Sufka KJ, et al. Anxiolytic properties of botanical extracts in the chick social separation-stress procedure.Psychopharmacology. 2001 Jan 1;153(2):219-24. PMID: 11205

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Date: October 06, 2005 10:08 PM
Author: Darrell Miller (dm@vitanetonline.com)

Magnesium is a dietary mineral with a wide array of biological activities in the body. Magnesium participates in numerous life-essential processes that occur both inside and outside cells. Magnesium deficiency impacts normal physiologic function on many levels. Adequate magnesium is a fundamental requirement for optimum function of the cardiovascular system, the nervous system and skeletal muscle, as well as the uterus and GI tract. Magnesium deficiency can affect health of the heart, bones and blood vessels and alter blood sugar balance [1].

Magnesium–Important for Everyone, Deficient in Many The average person living in a modern country today very likely consumes less than the optimum amount of magnesium [2]. An abundance of data collected over the last two decades shows a consistent pattern of low magnesium intake in the U.S. This pattern cuts a wide swath across various age-sex groups. The USDA’s Nationwide Food Consumption Survey found that a majority of Americans consumed less than the recommended daily magnesium intake [3]. Twelve age-sex groups were studied and this low magnesium intake was true for all groups except 0 to 5 year olds.

An analysis of the nutrient content of the diets of 7,810 individuals age four and above included magnesium among several nutrients where the amounts supplied by the average diet "were not sufficient to meet recommended standards" [4]. The FDA’s Total Diet study examined the intakes of eleven minerals, including magnesium, among eight age-sex groups. Data was collected four times yearly from 1982 to 1984. Levels of magnesium, calcium, iron, zinc and copper were low for most age-sex groups [5]. Surveys conducted in Europe and in other parts of North America paint a similar picture. Loss of magnesium during food processing is one explanation for this global lack of adequate dietary magnesium [6].

In particular, the elderly may be susceptible to magnesium deficiency for a variety of reasons, including inadequate magnesium intake, poor absorption due to impaired gastrointestinal function and use of drugs such as diuretics that deplete magnesium from the body [7]. It has recently been theorized that magnesium deficiency may contribute to accelerated aging, through effects on the cardiovascular and nervous systems, as well as muscles and the kidneys [8].

Women who take both synthetic estrogen and calcium supplements may be at risk for low blood levels of magnesium [9]. Estrogen promotes the transfer of magnesium from blood to soft–tissues. Low blood magnesium may result if the ratio of calcium to magnesium intake exceeds 4 to 1. Magnesium supplementation is thus advisable for women taking estrogen and calcium.

Young adults are not immune to magnesium deficiency. The University of California’s Bogalusa Heart Study collected nutritional data from a cross-sectional sample of 504 young adults between age 19 and 28 [10]. The reported intake of magnesium, along with several other minerals and vitamins, was below the RDA.

Glycine is a highly effective mineral chelator. This is because it is a low-molecular-weight amino acid, hence is easily transported across the intestinal membrane. A study conducted at Weber State University found this particular magnesium glycinate was absorbed up to four times more effectively than typical magnesium supplements.

Magnesium-the Versatile Mineral

The average adult body contains anywhere from about 21 to 28 grams of magnesium. Approximately 60 percent of the body’s magnesium supply is stored in bone. Soft tissue, such as skeletal muscle, contains 38%, leaving only about 1 to 2% of the total body magnesium content in blood plasma and red blood cells. Magnesium in the body may be bound either to proteins or "anions" (negatively charged substances.) About 55% of the body’s magnesium content is in the "ionic" form, which means it carries an electrical charge. Magnesium ions are "cations," ions that carry a positive charge. In its charged state, magnesium functions as one of the mineral "electrolytes."

Magnesium works as a "co-factor" for over 300 enzymatic reactions in the body. Metabolism uses a phosphate containing molecule called "ATP" as its energy source. Magnesium is required for all reactions involving ATP [11]. ATP supplies the energy for physical activity, by releasing energy stored in "phosphate bonds".

Skeletal and heart muscle use up large amounts of ATP. The energy for muscle contraction is released when one of ATP’s phosphate bonds is broken, in a reaction that produces ADP. Phosphate is added back to ADP, re-forming ATP. ATP also powers the cellular "calcium pump" which allows muscle cells to relax. Because it participates in these ATP-controlled processes, magnesium is vitally important for muscle contraction and relaxation. By controlling the flow of sodium, potassium and calcium in and out of cells, magnesium regulates the function of nerves as well as muscles [12].

Magnesium’s importance for heart health is widely recognized. The heart is the only muscle in the body that generates its own electrical impulses. Through its influence on the heart’s electrical conduction system, magnesium is essential for maintenance of a smooth, regular heartbeat [13]. Magnesium appears to help the heart resist the effects of systemic stress. Magnesium deficiency aggravates cardiac damage due to acute systemic stress (such as caused by infection or trauma), while magnesium supplementation protects the heart against stress [14]. This has been found true even in the absence of an actual magnesium deficit in the body.

Evidence suggests that magnesium may help support mineral bone density in elderly women. In a two-year open, controlled trial, 22 out of a group of 31 postmenopausal women who took daily magnesium supplements showed gains in bone density. A control group of 23 women who declined taking the supplements had decreases in bone density [15]. The dietary intakes of magnesium, potassium, fruit and vegetables are associated with increased bone density in elderly women and men [16]. In an interesting animal study, rats were fed diets with either high or low levels of magnesium. Compared to the high magnesium-fed rats, bone strength and magnesium content of bone decreased in the low-magnesium rats, even though these rats showed no visible signs of magnesium deficiency [17]. While this finding may or may not apply to humans, it raises the possibility that diets supplying low magnesium intakes may contribute to weakening of bone in the elderly.

Maximizing Absorption––Chelated Minerals Explained Mineral absorption occurs mainly in the small intestine. Like any mineral, magnesium may be absorbed as an "ion," a mineral in its elemental state that carries an electric charge. Mineral ions cross the intestinal membrane either through "active transport" by a protein carrier imbedded in the cells lining the membrane inner wall, or by simple diffusion. The magnesium in mineral salts is absorbed in ionic form. However, absorption of ionic minerals can be compromised by any number of factors, including: 1) Low solubility of the starting salt, which inhibits release of the mineral ion, and 2) Binding of the released ion to naturally occurring dietary factors such as phytates, fats and other minerals that form indigestible mineral complexes [18].

A second absorption mechanism has been discovered for minerals. Experiments have shown that minerals chemically bonded to amino acids (building blocks of protein) are absorbed differently from mineral ions. This has given rise to the introduction of "chelated" minerals as dietary supplements. Mineral amino acid chelates consist of a single atom of elemental mineral that is surrounded by two or more amino acid molecules in a stable, ring-like structure.

Unlike mineral salts, which must be digested by stomach acid before the desired mineral portion can be released and absorbed, mineral chelates are not broken down in the stomach or intestines. Instead, chelates cross the intestinal wall intact, carrying the mineral tightly bound and hidden within the amino acid ring. The mineral is then released into the bloodstream for use by the body. Research by pioneers in the field of mineral chelation and human nutrition indicates that the best-absorbed chelates consist of one mineral atom chelated with two amino acids. This form of chelate is called a "di-peptide." Compared to other chelates, di-peptides have the ideal chemical attributes for optimum absorption [19]. Dipeptide chelates demonstrate superior absorption compared to mineral salts. For example, a magnesium di-peptide chelate was shown to be four times better absorbed than magnesium oxide [20].

Consumer Alert! Not all "amino acid chelates" are true chelates. In order for a mineral supplement to qualify as a genuine chelate, it must be carefully processed to ensure the mineral is chemically bonded to the amino acids in a stable molecule with the right characteristics. The magnesium bis-glycinate/lysinate in High Absorption Magnesium is a genuine di-peptide chelate ("bis" means "two"). It has a molecular weight of 324 daltons, considerably lower than the upper limit of 800 daltons stated in the definition of "mineral amino acid chelates" adopted by the National Nutritional Foods Association in 1996 [21].

Bioperine® For Enhanced Absorption Bioperine® is a natural extract derived from black pepper that increases nutrient absorption.* Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine® [22].

Scientific References 1. Abbott, L.R., R., Clinical manifestations of magnesium deficiency. Miner electrolyte Metab, 1993. 19: p. 314-22. 2. Durlach, J., Recommended dietary amounts of magnesium: Mg RDA. Magnesium Research, 1989. 2(3): p. 195-202. 3. Morgan, K.e.a., Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition, 1985. 4: p. 195-206. 4. Windham, C., Wyse, B., Hurst, R. Hansen, R., Consistency of nutrient consumption patterns in the United States. J AM Diet Assoc, 1981. 78(6): p. 587-95. 5. Pennington, J., Mineral content of foods and total diets: the Selected Minerals in Food Survey, 1982 to 1984. J AM Diet Assoc, 1986. 86(7): p. 876-91. 6. Marier, J., Magnesium Content of the Food Supply in the Modern- Day World. Magnesium, 1986. 5: p. 1-8. 7. Costello, R., Moser-Veillon, P., A review of magnesium intake in the elderly. A cause for concern? Magnesium Research, 1992. 5(1): p. 61-67. 8. Durlach, J., et al., Magnesium status and aging: An update. Magnesium Research, 1997. 11(1): p. 25-42. 9. Seelig, M., Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnesium Research, 1990. 3(3): p. 197-215. 10. Zive, M., et al., Marginal vitamin and mineral intakes of young adults: the Bogalusa Heart Study. J Adolesc, 1996. 19(1): p. 39-47. 11. McLean, R., Magnesium and its therapeutic uses: A review. American Journal of Medicine, 1994. 96: p. 63-76. 12. Graber, T., Role of magnesium in health and disease. Comprehensive Therapy, 1987. 13(1): p. 29-35. 13. Sueta, C., Patterson, J., Adams, K., Antiarrhythmic action of pharmacological administration of magnesium in heart failure: A critical review of new data. Magnesium Research, 1995. 8(4): p. 389- 401. 14. Classen, H.-G., Systemic stress, magnesium status and cardiovascular damage. Magnesium, 1986. 5: p. 105-110. 15. Stendig-Lindberg, G., Tepper, R., Leichter, I., Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnesium Research, 1993. 6(2): p. 155-63. 16. Tucker, K., et al., Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr, 1999. 69(4): p. 727-736. 17. Heroux, O., Peter, D., Tanner, A., Effect of a chronic suboptimal intake of magnesium on magnesium and calcium content of bone and bone strength of the rat. Can J. Physiol. Pharmacol., 1975. 53: p. 304-310. 18. Pineda, O., Ashmead, H.D., Effectiveness of treatment of irondeficiency anemia in infants and young children with ferrous bisglycinate chelate. Nutrition, 2001. 17: p. 381-84. 19. Adibi, A., Intestinal transport of dipetides in man: Relative importance of hydrolysis and intact absorption. J Clin Invest, 1971. 50: p. 2266-75. 20. Ashmead, H.D., Graff, D., Ashmead, H., Intestinal Absorption of Metal Ions and Chelates. 1985, Springfield, Illinois: Charles C. Thomas. 21. NNFA definition of mineral amino acid chlelates, in NNFA Today. 1996. p. 15. 22. Bioperine-Nature's Bioavailability Enhancing Thermonutrient. 1996, Sabinsa Corporation: Piscataway, N.J.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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Stevia Sweetleaf with FOS - A Healthy Choice for Balanced Blood Sugar Levels
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Date: June 06, 2005 09:08 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Stevia Sweetleaf with FOS - A Healthy Choice for Balanced Blood Sugar Levels

Stevia Sweetleaf with FOS

Since the first sugar cane was brought from exotic South Pacific and Caribbean islands generations ago, Americans have had a love affair with foods that are super sweet but lack true nourishment. This has led to the development of literally thousands of good tasting but nutritionless foods that have contributed to childhood and adult obesity, energy depletion, mood swings, decreased brain function, and countless other negative effects on human health. Nature has also provided help in the form of an amazing herb from Paraguay, Stevia rebaudiana. Now Planetary Formulas brings you this beneficial herb with its introduction of STEVIA SWEETLEAF WITH FOS.

STEVIA SWEETLEAF contains a concentrated extract of stevia leaves and fructooligosaccharides (FOS) derived from the roots of the Chicory plant (Cichorium intiba). Stevia leaves have been used as a staple in the diet of the Gaurani Indians for more than 1500 years. One of stevia’s greatest attributes is that it contains no calories and no fat. Traditionally, it was used in foods and as a digestive tonic. Modern research has shown that stevia can help to balance blood sugar levels through an enhancement of insulin production. Balanced blood sugar levels in turn can help maintain stable energy levels, proper brain function, and emotional stability, while also reducing sugar cravings.

Planetary Formulas STEVIA SWEETLEAF WITH FOS contains a highly potent stevia extract containing 90% steviosides, the primary active components of stevia. Stevia has been used historically to improve digestion and gastrointestinal function. A healthy gastrointestinal tract is important for digestion, assimilation, the efficient burning of calories, the elimination of toxins, and healthy immune functions. The steviosides in stevia pass through the digestive process without chemically breaking down, so the body obtains no calories from it and it does not contribute to swings in blood sugar levels in the way that consumption of simple sugars do. Modern research suggests stevia has a positive effect on the pancreas, the primary sugar regulating organ of the body.

Unlike many stevia extracts, which are made with toxic extracting solvents, Planetary Formulas uses a water extraction process to avoid the presence of potentially toxic compounds. This is also more ecologically sound: a perfect supplement for people and planet.

FOS is a delicious, fiber-rich group of compounds that also serve as an herbal intestinal prebiotic. Prebiotics are substances that promote the body's natural production of friendly flora, most specifically, lactobacillus and bifidobacteria. The magic of FOS is that–like the steviosides–it passes through the stomach and small intestine undigested. Once in the colon, it helps to create a healthy bacterial environment. Part of its action in the colon is its ability to increase the production of short-chain fatty acids, which have beneficial effects on fat metabolism that are similar to fiber. The results are improvements in gastrointestinal function, bowel regularity, fat metabolism, and a cleansed colon--all of which are integral to health overall.

This combination of delicious flavor, fiber, blood sugar-balancing, and prebiotic activity makes STEVIA SWEETLEAF WITH FOS an ideal dietary supplement for healthy blood sugar levels, digestion, and colon health and as part of a healthy weight management program.

PLANETARY FORMULAS—YOUR SOURCE FOR ADVANCED HERBAL NUTRITION

Planetary Formulas is dedicated to bringing you the finest herbal supplement modern research has to offer. And now compelling research shows how the ingredients in STEVIA SWEETLEAF WITH FOS can help maintain normal blood sugar levels and a healthier lifestyle. Available in 2 oz, 4 oz and 8 oz sizes.

References:
Jeppesen, P., Gregersen, S., Poulsen, C., Hermansen, K. 2000. Stevioside Acts Directly on Pancreatic Beta Cells to Secrete Insulin. Metabolism Vol 49, No 2, 208-214. Alvarez, M., Curi, R., Bazotte, R., Botion, L., Godoy, J., Bracht, A. 1986. Effect of Stevia Rebaudiana on Glucose Tolerance in Normal Adult Humans. Brazilian Journal of Medicine Vol 19, 771-774. Toskulkao C., Sutheerawattananon M., Wanichanon C., Saitongdee P., Suttajit. 1995. Effects of Stevioside and Steviol on Intestinal Glucose Absorption in Hamsters, Journal of Nutritional Science Vitaminology 41 (1): 105-113. Melis, M. 1996. A Crude Extract of Stevia rebaudiana Increases the Renal Plasma Flow of Normal and Hypertensive Rats, Brazilian Journal of Medicine 29 (5): 669-675. Toskulkao, C., Sutheerawattananon M., Piyachaturawat. 1995. Inhibitory Effect of Steviol, A Metabolite of Stevioside, On Glucose Absorption in Everted Hamster Intestine In Vitro, Toxicology Letters 80 (1-3):153-159.



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TopPreviousNext

Date: May 09, 2005 06:10 PM
Author: Darrell Miller (dm@vitanetonline.com)

It's in the Blood

Natural alternatives abound for managing cholesterol levels, backed by a growing body of research ©VR By Paul Bubny

The National Cholesterol Education Program (NCEP) last July lowered the threshold for considering the use of statin drugs—a move which some say was motivated more by profits than scientific evidence. For example, the Center for Science in the Public Interest pointed out that eight of the nine authors behind the new recommendations had financial ties to statin manufacturers, which stand to reap billions of dollars more from a category that grossed $14 billion in the U.S. last year. And though the Food and Drug Administration (FDA) in January decided against authorizing over-the-counter (OTC) sales of statin drugs, drug companies would still like to see this happen.

“The medical establishment’s pushing of these drugs to becoming the number one category of prescribed drugs in the world has led them to keep lowering the total cholesterol number that triggers the drug recommendation,” said Neil E. Levin, C.C.N., D.A.N.L.A., nutrition educator, product formulator, and “Truth Advocate” for NOW Foods (Bloomingdale, IL), which produces a number of supplements for addressing cholesterol. “This is despite the lack of evidence that total cholesterol means much as regards cardiovascular risks.

“Other tests are much more important in terms of predicting risks, including CRP (C-reactive protein), the balance of different cholesterol fractions, and homocysteine,” he continued. “Add adult-onset diabetes to the risk factors for cardiovascular disease (CVD).”

At the same time, the allegation that enormous sales potential lay behind the lower threshold for prescribing statin drugs illustrates how widespread the problem of hypercholesterolemia (elevated total cholesterol) is. More than 100 million Americans have elevated cholesterol (total cholesterol values of 200 mg/dl and higher), and of these, more than a third have high cholesterol (levels of 240 mg/dl and higher), according to the American Heart Association. Those numbers have unfavorable implications for the incidence of CVD, as high cholesterol is considered a risk factor for coronary heart disease and stroke.

While statin drugs haven’t garnered the same degree of negative publicity that COX-2 inhibitors have suffered lately, safety concerns have arisen nonetheless. For one thing, these drugs lower the liver’s production of coenzyme Q10 (coQ10) along with its production of cholesterol. “CoQ10 is related to energy production and immune functions, is an antioxidant, and [is] an important cardiovascular nutrient,” Levin said. “It is not good to lower one’s coQ10 levels by half!”

Moreover, said Levin, statins increase the tendency of muscle tissues to break down. “Combined with inactivity or certain drugs, this can stimulate muscle wasting,” he said. “Muscle is where a good deal of calories are burned, so a loss of muscle could affect mobility and energy production, potentially adding to obesity problems. These muscle changes occurred in patients and persisted for years after treatment was discontinued, as shown by muscle biopsies, even if no obvious muscle problems were observed by the patients.”

And the last word on the subject may not have been spoken. Predicted Dr. Frank King, Jr. president of King Bio Natural Medicine (Asheville, NC), “Once the appropriate studies are finished, these drugs, along with hypertensives, will hit the fan bigger than the COX-2 inhibitors.”

Also looking toward the future, Levin said that of the 20 million Americans who will be “targeted” for statin drug prescriptions under the new NCEP guidelines, “Some of these will want to try natural methods first. Others will rebel at the side effects of the drugs and experiment with alternative products.”

King and Levin both saw opportunity for natural products in the fallout from drug safety concerns, with King projecting that sales of his company’s cholesterol-related homeopathic remedies will double in 2005. “The reports of deaths from drugs will always overshadow the trumped-up studies and news reports blasting dietary supplements,” said Levin. “Vioxx knocked vitamin E off the media’s radar screens pretty rapidly, though we still see ignorant reporters citing that [Johns Hopkins] vitamin E analysis as if it were true. But the comparable safety of supplements means that open-minded people will want to at least try natural therapies before signing in to a lifetime of drug therapies. Meanwhile, the studies on natural products will continue to build our credibility.”

Those studies keep coming in, with at least four major findings published in the past few months, plus a heart-health claim on walnuts authorized by FDA. They join a raft of earlier findings that link natural products—branded and otherwise—to healthy cholesterol levels.

"Blur of Products"

With so many natural alternatives to cholesterol drugs available, it can be hard to keep track. “As with any other category, the blur of products as they cascade over several shelves means that the retailer needs to have a good sense of what works and what they want to recommend to their customers,” Levin said. “Really, each person needs a protocol that would include antioxidants, fiber, vitamins, herbs, and oils. The pre-mixed cholesterol support formulas are a good starting place.”

To help retailers get a sense of “what works,” here is an alphabetical discussion of several nutrients that have demonstrated benefits in serum cholesterol levels. They include the following:

Barley may help lower cholesterol, according to a report in the American Journal of Clinical Nutrition (2004, vol.80, no.5: 1185-1193). Twenty-five adults with mild hypercholesterolemia consumed a controlled diet low in total fat, saturated fat, and cholesterol for 19 weeks. They then added whole-grain products containing barley to their diets that contained low (0 g), medium (3 g), or high (6 g) amount of beta-glucan per day for five weeks. Total cholesterol was reduced by 4 percent 9 percent, and 10 percent, respectively. The diet with the highest amount of beta-glucan led to a decrease in LDL cholesterol of 17 percent.

Chromium. There’s evidence, Levin said, that chromium in doses of 500 mg a day may decrease levels of low-density lipoprotein (LDL, the so-called “bad” cholesterol) and total cholesterol while raising levels of high-density lipoprotein (HDL, or “good” cholesterol). At the annual meeting of the American College of Nutrition last October, a poster presentation on the safety of Benicia, CA-based InterHealth Nutraceuticals’ ChromeMate niacin-bound chromium won first prize; among other things, the presentation cited chromium’s role in maintaining healthy blood lipid levels.

Fatty Acids. The latest in a long line of studies demonstrating the benefits of fatty acids in heart health is a study published in The International Journal of Clinical Pharmacology and Therapeutics in December 2004. It showed that docosahexaenoic acid (DHA), an omega-3 fatty acid, can restore normal blood vessel function in children with inherited high cholesterol. The study, which used Martek DHA produced from microalgae, concluded that restoration of normal blood vessel function has the “potential for preventing the progression of early coronary heart disease in high-risk children.”

“The evidence continues to accumulate on the cardiovascular benefits of DHA for people of all ages,” said Henry “Pete” Linsert, Jr., chairman and CEO of Martek Biosciences, an ingredient supplier based in Columbia, MD. “This study clearly indicates that DHA played an important role in healthy blood vessel function in the children in this study.”

On the Omega-Research.com Website maintained by fish oil manufacturer Nordic Naturals (Watsonville, CA) can be found summaries of several earlier studies linking omega-3 fatty acids to maintaining healthy blood lipid levels, as well as related benefits such as elasticity of the arteries. In a 2003 study published in the American Journal of Clinical Nutrition, it was found that women receiving a mixture of 4 g eicosapentaenoic acid (EPA) and DHA along with 2 g of gamma-linolenic acid (GLA) had lower levels of LDL cholesterol after 28 days compared to those who received either the EPA/DHA supplements without DHA, EPA/DHA with a smaller dose of GLA, or GLA alone.

Flax is another source of omega-3s, and Arkopharma/Health From The Sun (Bedford, MA) offers FiProFLAX in a variety of forms. Marketing director Hugues P. Mas said the flax is “QAI [Quality Assurance International] certified organic and guaranteed GMO [genetically modified organism]-free.” On its Website, the company offers a cholesterol quiz geared to consumers, discussing the importance of omega-3s as well as other nutrients.

Garlic. Adding to an already considerable body of research demonstrating that garlic can lower total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol, researchers at UCLA in 2003 reported that Kyolic aged garlic extract reduced or inhibited plaque formation in the arteries of 19 cardiac patients taking statin drugs.

Lead researcher Matthew Budoff, Ph.D. commented at the time that the study “suggests that aged garlic extract may be a useful and beneficial dietary addition for the people who have high cardiovascular risk or who have undergone heart surgery.” Budoff has since presented several trade show seminars sponsored by Los Angeles-based Wakunaga of America, the makers of Kyolic.

Guggul. In use for centuries as a component of Ayurvedic medicine, guggul—a gummy resin tapped from the Commiphora mukul tree, which is native to India—has been studied since the early 1960s for its hypolidemic (blood-lipid lowering) properties. Sabinsa Corp. (Piscataway, NJ), an ingredient supplier which produces a standardized extract under the brand name Gugulipid, says the studies on guggul indicate that its hypolipidemic activity can be attributed to more than one mechanism of action.

Among the possible mechanisms are: inhibition of cholesterol biosynthesis, enhancing the rate of excretion of cholesterol, promoting rapid degradation of cholesterol, thyroid stimulation, alteration of biogenic amines, and “high affinity binding and anion exchange.”

Homeopathy. “Homeopathy activates the body’s own control system to work properly,” said King. “This is the safest and most curative approach to take.

“Forcing the body into biochemical change even naturally doesn’t actually have the curative action of homeopathy,” King continued. “Homeopathy can even correct the genetic predispositions to disease we may have inherited from as deep as a thousand years into our family chain.” King Bio makes Artery/Cholesterol/BP, a homeopathic formula intended to help tone heart muscles and blood vessels.

Low glycemic index foods. In a study published in the February issue of the American Journal of Clinical Nutrition, researchers found that high glycemic load is negatively correlated to serum levels of HDL cholesterol. Assessing the relationship between blood levels of lipids and diet in a test population of 32 healthy males and females ages 11 to 25, the researchers found that glycemic load accounted for 21.1 percent of the variation in HDL cholesterol. They concluded that glycemic load appears to be an important independent predictor of HDL cholesterol in youth and noted that dietary restrictions without attention to glycemic load could unfavorably influence blood lipids.

Medicinal Mushrooms. Although its product SX-Fraction is intended primarily to address high blood sugar, Maitake Products, Inc. (MPI, Ridgefield Park, NJ) found in a clinical study that LDL cholesterol in diabetic patients declined modestly (from 142 mg/dl to 133 mg/dl) over a two-month period. Those taking SX-Fraction also lost about 7 lbs. in the same time period.

“The more impressive lowering of cholesterol, however, comes from the dietary fiber that is found in all medicinal mushrooms,” said Ellen Shnidman, manager of scientific affairs at MPI. She cited animal studies which documented the cholesterol-lowering properties of four different mushrooms: maitake, shiitake, agaricus, and enokitake.

For example, a study reported in the September 1996 issue of Alternative Therapies showed “a 44 percent reduction in total cholesterol in rats consuming maitake mushroom in their diet,” said Shnidman. “This cholesterol reduction is accompanied by weight loss, relative to rats eating a similar high-choelsterol diet without mushrooms. Apparently, cholesterol is excreted by the rats in sufficient quantity to aid in weight loss.”

Oat bran. A 2004 consumer study conducted by the Natural Marketing Institute (NMI, Harleysville, PA) for Nurture, Inc. (Devon, PA), which produces the ingredient OatVantage, found that 63 percent of consumers managing their cholesterol levels prefer oat-based ingredients.

Oat bran is the subject of a health claim authorized by FDA in 1999, and NMI research found that 69 percent of respondents preferred the FDA-permitted health claim, “Helps Lower Cholesterol,” over the model structure-function claim, “Helps Maintain Healthy Cholesterol Levels.” “This is significant for food, beverage, and dietary supplement manufacturers who want to increase sales by using a more consumer-desired claim on the product label,” said Griff Parker, Nurture CEO.

Plant sterols. Also the subject of an FDA-approved claim for heart health, plant sterols (structurally similar to cholesterol in humans) can block the absorption of cholesterol, according to a number of studies. In an “Ask the Doctor” publication (available online at www.atdonline.org), Decker Weiss, N.M.D. noted that sterols enter the same receptor sites that cholesterol enters on its way to the bloodstream. “The cholesterol, being blocked from absorption, remains in our intestines where it is eventually excreted,” Weiss wrote. General Mills has just introduced Yoplait Healthy Heart, a yogurt high in plant sterols.

Policosanol. A mixture of fatty alcohols derived from sugar cane or beeswax, policosanol has been favorably compared in clinical studies to several types of prescription drugs for managing cholesterol. On its own, policosanol was found in a 1999 study to reduce LDL cholesterol while raising levels of HDL cholesterol.

Probiotics. “Several studies have indicated that consumption of certain cultured dairy products resulted in reduction of serum cholesterol, as well as triglycerides,” wrote Dr. S.K. Dash, president of probiotic manufacturer UAS Laboratories (Eden Prairie, MN), in his Consumer Guide to Probiotics. Among other studies, Dash cited two controlled clinical studies from the VA Medical Center at the University of Kentucky.

“In the first study, fermented milk containing [Lactobacillus] acidophilus was accompanied by a 2.4 percent reduction of serum cholesterol concentration,” he wrote. “In the second study, a different L. acidophilus strain reduced serum cholesterol concentration by 3.2 percent. Since every 1 percent reduction in serum cholesterol concentration is associated with an estimated 2 to 3 percent reduction in risk for coronary heart disease [CHD], regular intake of fermented milk containing an appropriate strain of L. acidophilus has the potential of reducing risk for [CHD] by 6 to 10 percent.”

Dash said his company’s DDS Probiotics contain DDS-1 L. acidophilus, “which has been researched and demonstrated to show cholesterol-lowering effect.”

Psyllium. “Internal cleansing is very important” in maintaining healthy cholesterol levels, “especially if you do it with a lot of fiber,” said Sunil Kohli, vice president of Chino, CA-based Health Plus, Inc. The cholesterol-managing ability of fiber in general and psyllium in particular is “very well-established,” he said.

However, Kohli said, “It will probably do you no good if it’s random. It should be done on a regular basis, and it should be supervised. Consulting the doctor or pharmacist is important.”

Soy. The protein in soy “has evidence of lowering total cholesterol and LDL cholesterol, based on reviews of studies using over 20 g of soy protein per day,” said Levin. “Soy isoflavones are considered only partly responsible for this effect.”

Sytrinol. A patented proprietary formula derived from natural citrus and palm fruit extracts and containing citrus polymethoxylated flavones and palm tocotrienols, Sytrinol has been shown in clinical trials to improve total cholesterol, LDL cholesterol, and triglycerides by up to 30 percent, 27 percent, and 33 percent, respectively. Having just wrapped up Phase III of a long-term trial of Sytrinol, Chicago-based SourceOne Global Partners, which owns the exclusive worldwide license for intellectual property associated with the ingredient, is commencing a study that combines Sytrinol with plant sterols.

Tocotrienols. On its Website discussing the science and benefits of tocotrienols (www.tocotrienol.org), ingredient supplier Carotech Inc. (Edison, NJ) identifies several benefits for blood lipid levels. Tocotrienols, according to the Website, have been shown to “inhibit cholesterol production in the liver, thereby lowering total blood cholesterol;” “[suppress] hepatic HMG-CoA reductase activity [and result in] the lowering of LDL cholesterol levels;” and “inhibit cholesterogenesis by suppressing HMG-CoA reductase.”

New Weapons

There are also nutrients that are emerging as potential weapons in the fight against cholesterol. Levin cited rice bran oil, resveratrol, pantethine, l-carnitine, and niacin as showing promise.

With all of this, Levin said, it’s important for retailers to remember that “they are not allowed to discuss diseases and remedies unless there is an approved FDA health claim allowed on the label, as with soy protein and plant sterols. What is allowed are structure-function claims such as ‘cholesterol support,’ ‘promoting normal, healthy circulation,’ ‘homocysteine regulators,’ etc.”

Supplementation is only one tool for managing cholesterol levels, manufacturers pointed out. “Besides nutrition, lifestyle is a key to controlling cholesterol,” Levin said. “Eating a variety of antioxidant-rich foods will prevent the liver from churning out cholesterol as a ‘cheap’ antioxidant. The body uses oxidized cholesterol to patch leaky and damaged blood vessels, so the ability to build healthy collagen is a must, using nutrients like vitamin C, Pycnogenol, rutin, hyaluronic acid, and MSM.

“Don’t forget exercise and stress reduction,” he added. “Stress results in high cortisol levels—usually accompanied by poor blood lipid levels—and a lack of good sleep to produce unhealthy people.” VR

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