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Cerebral
  Messages 1-30 from 32 matching the search criteria.
Memory Loss - The Benefits of DHA to your Brain and Memory Darrell Miller 11/9/13
DHA Food Sources? Darrell Miller 10/31/12
How Does GABA Help Brain Function? Darrell Miller 5/16/12
How Does Taurine Help the Brain? Darrell Miller 5/13/11
Can Butterbur Help Me with Migraines Darrell Miller 4/2/11
What is Vinpocetine and How Does it Help with Memory? Darrell Miller 3/24/11
How to detoxify from heavy metal aluminum toxitity Darrell Miller 11/9/10
Periwinkle - Vinpocetine Darrell Miller 10/9/09
Ginkgo Biloba Extract Darrell Miller 9/19/08
DHA - Fish Oil Darrell Miller 7/31/08
A Periwinkle Extract Vinpocetine May Promote Cerebral Blood Flow Darrell Miller 12/1/07
High Potency Premium Fish Oil for Adults or Children. Darrell Miller 6/5/06
Benefits of Best Alpha Lipoic 35! Darrell Miller 2/12/06
Benefits of Alpha Lipoic Acid Darrell Miller 10/13/05
Oral Chelation with EDTA Darrell Miller 10/3/05
UROVEX: BUTTERBUR EXTRACT Supports healthy urinary urge and frequency Promotes healthy ... Darrell Miller 6/29/05
REFERENCES Darrell Miller 6/25/05
Migraine Headaches and Ginkgo Darrell Miller 6/25/05
Alzheimer’s Disease and Ginkgo Darrell Miller 6/25/05
Treating and Preventing Age-Related Mental Disorders Darrell Miller 6/25/05
Increased Brain Power and Memory with Ginkgo Darrell Miller 6/25/05
Herbal Forms Darrell Miller 6/25/05
Improove Memory ... Darrell Miller 6/9/05
PHOSPHATIDYL SERINE (PS) - Maintain healthy cells ... Darrell Miller 6/4/05
Mega Mind - re-align your body systems ... Darrell Miller 6/3/05
Intimate Response - The Freedom to Change. Boost intimacy Darrell Miller 6/2/05
Higher Mind - Smart Nutrients for the Performance of a Lifetime... Darrell Miller 6/2/05
DHA Neuromins - Feed Your Brain! Darrell Miller 6/1/05
Attentive Child - Enhances Mental Concentration ... Darrell Miller 5/31/05
Arcticpure EFA and EPA Fish Oil supplement ... Darrell Miller 5/31/05



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Memory Loss - The Benefits of DHA to your Brain and Memory
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Date: November 09, 2013 06:34 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Memory Loss - The Benefits of DHA to your Brain and Memory

Benefits of DHA

brain memoryAs the human being grows older, he/she experiences physiological changes that may interrupt normal brain function. For instance, it may take him/her longer than usual to learn new information and retain it because the brain is not as quick as it used to be. As a matter of fact, the slowing down of mental processes is often mistaken as total memory loss. But in real sense, the brain can learn or retrieve information if it is given more time.

The brain has the ability to produces new cells regardless of a person’s age. This simply means aging does not necessarily cause memory loss. It is your health habits, lifestyle and daily activities that affect the health of your brain. Everyone can avert memory loss, boost their cognitive skills and protect their grey matter, age notwithstanding.

How Does DHA Improve Memory?

DHA is an acronym for the words Docosahexaenoic acid. DHA is an omega-3 fatty acid that forms the main structural element of the testicles, sperm, the Cerebral cortex and retina. The following foods are rich in DHA: herring, anchovies, fish roe or caviar, Bluefin, sardines, algae, swordfish, breast milk (instant milk formula as well). DHA is also manufactured from microalgae for commercial purposes.

A study was conducted to find out whether DHA supplements can boost brain function in individuals experiencing age-related cognitive decline. It was established that DHA is effective in improving memory and learning. In this study, the subjects were administered with either 900mg per day DHA or placebo for a period of six months. Learning and memory tests were conducted before and after the study. Those who were administered with DHA demonstrated significant improvements in both learning and memory after the study was complete. In another study, DHA was administered to patients diagnosed with Alzheimer’s disease, but the patients did not record any significant change. It can therefore be concluded that DHA is most effective when used as a preventive measure. In the first study, subjects had mild cognitive disorders but showed remarkable improvement after being supplemented with DHA, unlike those in the second study. 

Conclusion

Memory loss can have devastating effects on the patient and his family, but this can be avoided through proper nutrition and supplementation. DHA supplements ensure that there are sufficient amounts of this vital fat in our brain tissues to maintain normal brain function even as we age. A dose of 100mg everyday normalizes cell membrane stores of DHA over time.

References:
  1. http://www.drfuhrman.com/default.aspx
  2. http://www.medicalnewstoday.com/articles/247456.php
  3. http://www.helpguide.org/life/prevent_memory_loss.htm
  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838628/

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DHA Food Sources?
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Date: October 31, 2012 11:58 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: DHA Food Sources?

DHA

DHA, or Docosahexaenoic acid, plays an important role in the structure of the retina, Cerebral cortex, sperm, and testicles. When levels of this substance decline, it has negative effects on cognitive function. Low levels are also suspect in the onset of Alzheimer's disease.

The best ways to get this omega-3 fatty acid are from natural sources. Babies can get their needs taken care of through breast milk and enriched formula. Adults need to find food sources for their needs.

Food Sources Of DHA

Cold-water varieties of fish are often excellent sources. These include salmon, bluefin tuna, albacore tuna, swordfish, anchovies, herring, sardines, caviar, and fish roe. Other types of seafood are also good sources for DHA, including crab, shrimp, lobster, clams, mussel, octopus, and scallops. Eggs and some organ meats are other sources for this essential fatty acid. For most vegetarians, eating seafood is not an option. An alternative vegetarian source is algae and seaweed. Supplements are another way to get DHA when fish, seafood, seaweed, and algae are not an option.

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How Does GABA Help Brain Function?
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Date: May 16, 2012 08:43 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does GABA Help Brain Function?

Gamma Amino Butyric Acid, GABA, is a neurotransmitter found in central nervous system. It has an inhibitory action on nerve transmission and helps in regulating brain activity and function.

Healthy functioning of brain is important to achieve optimal health. In today's fast paced lifestyle, work related stress and anxiety have taken a toll on man's health. Mental stress and anxiety can cause havoc on the internal systems of the body. According to American Psychological Association, stress can affect the physical as well as mental health of a person. It impairs the brain's ability to block certain toxins and can lead to certain aging conditions such as diabetes, cardiovascular diseases and cancer. Stress can affect brain's normal functioning and affect intellectual abilities and memory. GABA helps in calming the stress and thereby enhancing the functioning capacity of the brain. Let us understand how does GABA help in brain function?

Role of GABA in Cerebral cortex:

The nervous system comprises of neurons, brain, spinal cord and neurotransmitters. The role of neurotransmitters is to transmit nerve signals from one neuron to another or from neuron to muscle or gland cell. The most abundant neurotransmitters in Cerebral cortex, Glutamate and GABA, have opposite action on the neuron cells.

Glutamate is an excitatory neurotransmitter, which results in neuron fires and sends an electrical impulse down its length. On the other hand, GABA, made from glutamate, has inhibitory action on the nerve cells and does not allow the electrical impulse to pass through the neuron. In case of deficiency of GABA, nerve cells will fire too often and too easily, resulting in wide number of anxiety disorders such as panic attacks, seizure disorders, headaches and other cognitive impairment disorders. Hence, GABA helps in stopping the transmission of nerve impulses from one neuron to another and thereby regulating brain activity. It has a calming effect on the brain.

Once the activity in the brain is regulated and cognitive abilities are restored by GABA, the person can think better and perform better. This natural tranquilizer allows your brain to function more efficiently. Studies have related many higher brain functions such as visual recognition and language comprehension with declining levels of GABA with advancing age. This results in easy firing of neurons by stimulus, slowing down processing of information in brain.

Health benefits of GABA:

According to studies, GABA plays an important role in healthy functioning of mind and body. It helps in:

1. Treating conditions like depression, anxiety, Attention Deficit Hyperactivity Disorder and epilepsy. The result is due to the calming effect of GABA on brain activity. It helps in clear thinking and better reasoning.

2. Preventing age related conditions such as cardiovascular disorder, diabetes and cancer.

3. Inducing a sense of relaxation by providing tranquilizing effect. GABA increases dopamine hormone in the body and gives a sense of euphoria. You remain happy and of course this has a positive effect on sexual system.

4. Relieving pain.

5. Promoting body building and losing extra fat.

GABA can be purchased as a supplement in the form of pill, capsule or powder form. It is a natural alternative for relieving stress and improving brain function.

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How Does Taurine Help the Brain?
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Date: May 13, 2011 01:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does Taurine Help the Brain?

Taurine is an amino acid often added to energy drinks. There have been several theories on how taurine affects brain chemicals and improve cognitive function. For many years, it has been compared to caffeine due to its effects on the human brain that appear to enhance mood. Its exact mechanisms of action remain a mystery to the scientific community, but recent studies are believed to be closing in.

It has long been known that taurine crosses the blood brain barrier, allowing it to exert some effects on several neurotransmitters found in the central nervous system. It has been tied to the alleviation of many mental illnesses, such as epilepsy, post traumatic stress disorder, clinical depression, bipolar disorder, and anxiety, making it the subject of a number of studies in the past few years.

Rebalances Brain Chemicals

It has been postulated that taurine influences the activities of neurotransmitters in the brain, but only recently has brain scientists been able to actually track its activities in the brain. A team of researchers at Cornell University managed to find a site for the neurological activity of taurine, with initial results pointing to its relationship with gamma the neurotransmitter aminobutyric acid, or GABA. The researchers do not discount the possibility that taurine may even have a receptor of its own.

Whether taurine interacts with brain chemicals is no longer debatable as it creates homeostasis in the central nervous system. It acts on receptors that the researchers discovered to be the same receptors present in GABAergic mechanisms. That being said, scientists remain inconclusive as to how its interaction with GABA receptors provides energy-boosting benefits as it is marketed in the food and drug industries.

Prevents Neuron Damage

The scientific community is convinced that taurine has neuroprotective properties. High levels of taurine in the brain have been observed to protect brain tissues from Cerebral ischemia. Taurine has been linked to many metabolic pathways that are known to promote neurological health, such as the activation of glycine receptors and the regulation of enzymes called cysteine-dependent aspartate-directed proteases.

In addition, taurine serves as antioxidants that protect nerve cells from cellular damage brought on by oxidative stress. The presence of taurine within cells reduces damage from calcium excesses and increases mitochondrial events. For decades, supplementation of taurine has benefited sufferers of brain ischemia, epileptic seizures, panic attacks, anxiety symptoms, and even alcohol withdrawal.

Enhances Cognitive Function

Taurine has already been associated with physiological functions the hypothalamus controls, such as sleep-wake cycle and responses to fatigue. In several laboratory studies, administrations of taurine by way of intraperitoneal injection have successfully induced social interaction in animal subjects. It is one of the amino acids that affect cognitive development, especially in children. While it is one of the most abundant amino acids in the brain, it is depleted as we age, making supplementation a good option.

Protect your brain with Taurine by taking it daily!

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Can Butterbur Help Me with Migraines
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Date: April 02, 2011 12:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can Butterbur Help Me with Migraines

Butterbur and Headaches

Butterbur has helped countless of migraine sufferers for more than three decades. In Europe, it is available as a prescription drug, which neurologists have prescribed since 1972. It has been the subject of numerous studies and reviews in a span of 40 years that have come to a conclusion that it does alleviate symptoms of migraine and reduce frequency of attacks. It is one of the herbal remedies clinically tested in migraine centers in the US. To date there has been no recorded adverse effects and harmful drug interactions, and as such available in the US over the counter, no prescription required. It has been compared to beta blockers and anticonvulsants and in general believed to be better than both of these more common treatments.

Petasites hybridus, the common butterbur, is the herb where butterbur extracts are obtained from although other species that belong to the genus Petasites are also known to produce the same health benefits. Petasites comprises up to 20 plant species widely distributed across the globe, a number of which have been tied to folk medicine throughout the ages. Petasites hybridus is native to North America and thrive well in marshes and wetlands, where there is a significant amount of moisture in the soil.

American Indians have long used its rhizomatous roots to fight off headaches and inflammation-induced diseases, such as asthma attacks and hay fever. Indeed the discovery of the organic compounds petasin, isopetasin, and oxopetasin explained its long-standing association with the treatment of migraines and allergies. Today most butterbur preparations do not contain pyrrolizidine alkaloids, which were identified to cause liver damage. That being said, it is still best to seek professional advice and ask assistance in choosing products from a reputable laboratory.

Interferes with Releases of Pain Chemicals

The phytochemicals unique to Butterbur have been well investigated, and results point to their effects on inhibiting the productions of local pain chemicals, which are pro-inflammatory in nature. Leukotrienes are lipid mediators that supervise the productions of other intermediaries of inflammation. Prostaglandins are responsible for vasodilation of blood vessels and their consequent sensitization to pain. Butterbur has been observed to influence these two pain chemicals.

Plays the Role of a Natural Beta Blocker

Beta-adrenergic antagonists, or simply beta blockers, are a class of drugs that target endogenous catecholamines implicated in migraine attacks. Epinephrine and norepinephrine are catecholamines that act on beta-andrenergic receptors, leading to a reduced blood flow in the brain. This results in the spasmodic contractions of Cerebral blood vessels characteristic of migraines. Butterbur works on the principle of blocking the effects of catecholamines and inducing normal blood flow to the brain.

Produces No Known Serious Side Effects

Most analgesics and beta blockers have been associated with several adverse effects, which more often than not include nausea, dizziness, and muscle weakness. Many have been reported to cause weight gain. None of these have been linked to regular use of butterbur, one of the reasons why it has enjoyed a surge in popularity in recent years.

If you suffer from Migraine headaches, give butterbur a try!

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What is Vinpocetine and How Does it Help with Memory?
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Date: March 24, 2011 02:18 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What is Vinpocetine and How Does it Help with Memory?

Vinpocetine And Brain Health

Vinpocetine is a derivative of an organic compound found in the plant species Vinca minor, or common periwinkle. It is best known for its neuroprotective effects and used in Europe and Japan in treatment of age-related cognitive decline. More often than not, its activities inside the human body are described as vasodilator, which means it increases blood flow. It has also seen a growing presence in the North American market as a dietary supplement.

Vinpocetine is available as a prescription drug in certain European countries and Japan and has shown to be speed up prognosis of patients who suffered cerebrovascular accident, or CVA, which is commonly referred to as stroke. Most cases of cerebrovascular accident are brought on by ischemia, or very poor circulation of blood to certain parts of the brain. This is exactly what vinpocetine is beneficial for, and recommended dosages have so far yielded very encouraging results.

Improves Blood Circulation in the Brain

It has long been postulated that one of the mechanisms of action of vinpocetine is limiting the effects of Na+ channels that are sensitive to voltage. This creates a neuroprotective effect believed to contribute to mental clarity and sustained attention. Striatal nerve endings produce extracellular Ca+ ions that induce neuronal damage through a phenomenon called excitotocity. High levels of Ca+ ions are now alleged to be correlated with voltage-sensitive Na+ channels. Striatal nerve endings see a decline in Ca+ ions when Na+ channels are influenced by vinpocetine, and in the process lessen excitotoxicity.

Attenuates Ischemic Neuronal Damage

In addition to limiting neuronal damage induced by excitotoxicity, which in turn results from Cerebral ischemia, vinpocetine plays an active role in the upkeep of brain cells after being subjected to ischemic damage. As a vasodilator, it not only counters the effects of ischemia but also significantly increases the brain’s access to bioactive molecules like oxygen and other nutrients exclusively distributed by the circulatory system.

It also inhibits the enzyme phosphodiesterase, which is specialized for the breakdown of cyclic adenosine monophosphate, or cAMP, and cyclic guanosine monophosphate, or cGMP. By so doing, vinpocetine contributes to glucose metabolism and energy production in the brain, and at the same time, improves the distribution of bioactive compounds in the central nervous system.

Displays Neuroprotective Activities

Vinpocetine and its precursor belong to a group of indole alkaloids known as tryptomines, which are present in the human brain and the rest of the central nervous system in minute quantities. These organic compounds make up several psychoactive drugs and in the human body act as neuromodulators and neurotransmitters in the form of melatonin and serotonin.

Vinpocetine in particular displays activities that are primarily anti-inflammatory in nature. Several studies point to its effects on the enzyme complex called IkB kinase, which regulates cellular responses to inflammation, by preventing the translocation of a protein complex called responsible for the process of inflammation within cells.

In a Nutshell, vinpocetine can help you think clearer and protect the brain from inflammation and free radical damage. Give vinpocetine a try today!

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How to detoxify from heavy metal aluminum toxitity
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Date: November 09, 2010 06:04 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How to detoxify from heavy metal aluminum toxitity

nacAlthough aluminum is not a heavy metal, it can be toxic if present in excessive amounts or small amounts if it is deposited in the brain. Many of the symptoms of aluminum toxicity are similar to those of Alzheimer’s disease and osteoporosis. Aluminum toxicity can often lead to colic, rickets, gastrointestinal disturbances, poor calcium metabolism, extreme nervousness, anemia, headaches, decreased liver and kidney function, forgetfulness, speech disturbances, memory loss, softening of the bones, and weak, aching muscles. Since aluminum is excreted through the kidneys, toxic amounts of aluminum can often impair kidney function.

When aluminum salts accumulate in the brain, seizures and reduced mental function can often result. In order to reach the brain, aluminum must pass the blood-brain barrier, which is an elaborate structure that filters the blood before it reaches the vital organ. Although elemental aluminum does not ordinarily pass through this barrier, certain aluminum compounds, such as aluminum fluoride, will. Many municipal water supplies are treated with aluminum sulfate and fluoride. These two chemicals readily combine with each other in the blood and are poorly excreted in the urine. The absorption of high levels of aluminum and silicon in the intestines can result in the formation of compounds that accumulate in the Cerebral cortex and prevent nerve impulses from being carried to and from the brain in the proper manner. This situation can be aggravated by a chronic calcium deficiency.

People who have spent their career in aluminum smelting plants for long periods have been known to experience dizziness, impaired coordination, and a loss of balance and energy. When aluminum accumulates in the brain, the above symptoms are often caused. Perhaps the most alarming thing to note it that there is evidence to suggest that long-term accumulation of aluminum in the brain may contribute to the development of Alzheimer’s disease. It has been estimated that an ordinary person ingests about 3 and 10 milligrams of aluminum a day. Aluminum, being the most abundant metallic element in the earth’s crust, is primarily absorbed in the body through the digestive tract, but can also be absorbed through the lungs and skin. Additionally, aluminum can be absorbed by and accumulate in the body tissues. Since aluminum permeates our air, water, and soil, it can be found naturally in varying amounts in almost all food and water. Aluminum is also used to make cookware, cooking utensils, and foil, along with being present in many other everyday products including over-the-counter painkillers, anti-inflammatories, douche preparations, antacids, baking powder, food processing, antiperspirants, toothpaste, dental amalgams, bleached flour, grated cheese, table salt, beer, and municipal water supplies.

The following nutrients are very helpful when dealing with aluminum toxicity: apple pectin, calcium, magnesium, coenzyme A, garlic, kelp, lecithin capsules or granules, l-glutathione, a multivitamin and mineral complex, SAMe, vitamin B complex, N-Acetyl Cysteine, and vitamin E. Additionally, the following herbs are great for blocking damage to the body from toxic heavy metals and radiation when taken regularly: burdock root, Echinacea, ginseng, ginkgo biloba, and fiber. Other recommendations to help prevent aluminum toxicity include maintaining a diet that is high in fiber and includes apple pectin; using only stainless steel, glass, or iron cookware, with stainless steel being the best; and being aware of the products that contain aluminum by reading labels and avoiding those that contain aluminum. Sulfur container foods like N-Acetyl Cysteine can help find up heavy metals and eliminate them from the body. If you suspect you have heavy metal toxicity, consult your health care provider immediately.

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Periwinkle - Vinpocetine
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Date: October 09, 2009 10:23 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Periwinkle - Vinpocetine

periwinkle colorsPeriwinkle can be found natively growing in North America, Europe, China, and India. The plant is a semi woody evergreen perennial. It is known by three names: Vinca, Periwinkle, and Myrtle. Typically, the plant is grown as an annual. It has a woody stem that can be found near the base and grows two to three feet tall and spreads out just as wide. The plant has a long life span of approximately twenty years. It also has a moderate growth rate. The plant has dark green foliage and bright blue flowers. The leaves are retained from year to year and are about two to three inches in length. This plant is very easy to grow, requiring little or no attention. Typically, it does best in poor, well drained soils. The flowers will suffer if the soils are too fertile. The periwinkle plant needs full sun or partial shade. It should be watered moderately during the growing season, but it is relatively drought resistant once it is established. The plant does not tolerate over watering. Fungus problems can occur in humid or wet weather.

For centuries, periwinkle has been used in different areas of the world to treat a variety of conditions. This herb grows in temperate climates and is often grown as an ornamental plant. Periwinkle juice from the leaves of the plant is used in India and applied to bee stings and bug bites. The plant grows well in Hawaii. The extract has been applied to wounds to stop bleeding. This herb can be found growing in South America and has been used for a wide variety of medicinal purposes. Periwinkle was used by native healers in Madagascar for cancer. Vincristine sulfate and vinblastine sulfate, two anticancer drugs, were developed from the periwinkle plant after the herbal healers in Madagascar were studied.

Periwinkle is considered to be a good binder. It can be chewed to stop bleeding in both the nose and mouth. It has been used historically for female complaints including excessive menstrual bleeding and uterine discharge. It also helps in aiding blood coagulation in wounds. This herb is effective in treating colitis, diarrhea, hemorrhoids, high blood pressure, headaches, migraines, nervous conditions, and diabetes.

Studies have found that periwinkle possesses anticancer attributes. Anticancer agents in periwinkle have been used to treat Hodgkin’s disease, leukemia, and cancer of the lungs, liver, and kidneys, along with other types of cancer. periwinkle More Periwinkle can be found natively growing in North America, Europe, China, and India. The plant is a semi woody evergreen perennial. It is known by three names: Vinca, Periwinkle, and Myrtle. Typically, the plant is grown as an annual. It has a woody stem that can be found near the base and grows two to three feet tall and spreads out just as wide. The plant has a long life span of approximately twenty years. It also has a moderate growth rate. The plant has dark green foliage and bright blue flowers. The leaves are retained from year to year and are about two to three inches in length. This plant is very easy to grow, requiring little or no attention. Typically, it does best in poor, well-drained soils. The flowers will suffer if the soils are too fertile. The periwinkle plant needs full sun or partial shade. It should be watered moderately during the growing season, but it is relatively drought r

The entire periwinkle plant is used to provide antineoplastic, astringent, hemostatic, nervine, and sedative properties. Primarily, periwinkle is extremely beneficial in dealing with cancer, diabetes, hemorrhoids, nervousness, and ulcers. Vincamine is an alkaloid found in this plant has been studied and found to support Cerebral blood flow, and oxygen and glucose utilization. It may also support cognitive function and enhance memory and concentration when taken regularly.

Additionally, the herb is very helpful in treating bleeding, congestion, chronic constipation, cramps, dandruff, chronic diarrhea, internal hemorrhages, leukemia, menstrual bleeding, excessive mucus, nightmares, skin disorders, sores, and toothache. In order to obtain the best results when supplementing with this, or any herb, it is important to consult your health care provider before beginning any regimen. For more information on the many beneficial effects provided by periwinkle, please feel free to consult a representative from your local health food store with questions.

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Ginkgo Biloba Extract
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Date: September 19, 2008 09:25 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Ginkgo Biloba Extract

Ginkgo biloba, also known as the maidenhair tree, grows naturally in two small areas of Eastern China. It is believed that even these sources are artificial, and planted and maintained by monks over many centuries, and that there are no true natural sources of the tree left. Other than these, all living ginkgo trees are now artificially farmed.

The ginkgo seeds contain nuts that are a traditional food in China, served at Chinese New Year, and on other special occasions such as weddings, and is also used in traditional Chinese medicine. The seeds have been used in the treatment of coughs and asthma, and during the late 1970s and 80s, the uses of ginkgo biloba in medicine was extensively investigated with a view to determine the range of conditions that the tree could be used to treat. Given that many ancient Chinese remedies have found to be effective, and with a relevant scientific basis, this was a logical step.

It has been established that ginkgo biloba could have three possible effects on the body. These are:

* Improvement in circulation including that in the small capillaries.
* An antioxidant effect against free radicals.
* Prevention of some of the harmful effects of blood clotting and aggregation of platelets.

The last of these has been responsible for many cardiovascular conditions, and disorders of the kidneys, lungs and central nervous system, and is due to the effect of the platelet-activating factor (PAF) that ginkgo appears to inhibit.

Before delving deeper into the possible beneficial effects of Ginkgo, let us first examine the active ingredients believed to be involved in the perceived beneficial effects.

Ginkgo leaf extract contains terpenoids (bilobalides and ginkgolides) and flavonoid glycosides. Flavones can reduce the fragility of capillaries, and protect the body from blood loss through damaged capillaries, particularly in the brain. The Ginkgolides, particularly ginkgolide B, inhibit the platelet-activating factor and so increase the fluidity of the blood that improves circulation, again particularly in the micro-capillaries of the brain. This is also why it is believed to reduce the incidence of Cerebral thrombosis and resultant strokes.

The antioxidant effect of ginkgo biloba extract (GBE) has been widely studied, and by scavenging free radicals the extract can help to prevent cell membrane damage, and so prevent cells from being destroyed. It has been established that pretreatment of cells with GBE can prevent such damage in rats.

The anti-inflammatory properties of ginkgo biloba, as seen in some asthma patients for example, is thought to be due to the inhibition of the platelet-activating factor (PAF) by ginkgolide B, PAF playing a significant part in the inflammatory response to allergens, and PAF is now believed to be responsible for conditions such as asthma, renal diseases, central nervous system disorders and ischemia, a restriction in the blood supply, particularly to the brain.

It follows, therefore, that the effect of GBE on these conditions is likely to be due to PAF inhibition, and a reduction in the inflammatory response to a number of conditions. What evidence is there for this? In fact, results of the trials carried out have been inconclusive one way or the other.

Hence, a trial published by the Journal of the American Medical Association reported no effects after a 6 week trial of Ginkgo on Alzheimer’s and memory disorders. However, other trials have indicated positive effects after 6 weeks, and it could be that the GBE has to be taken for more than 6 weeks for any effects to be noticed. It is certainly believed to be a longer term treatment rather than have instant results, although some tests have shown improvement in concentration for up to 2.5 hours after treatment. The bulk of the evidence is favorable on the effect of GBE on memory disorders.

Test on rats, in which the blood flow to the brain was mechanically blocked by carotid compression, indicated that ginkgo biloba promoted an increase in the glucose and ATP levels in the brain neurons. Other trials have indicated that neurological damage in mice subjected to neurotoxins was reduced by the administration of GBE, and while not conclusive with respect to humans, the effect of GBE on the brain appears to be more than just opinion.

To sum up, ginkgo biloba is believed to be effective in treating the following disorders by virtue of its effect in improving the fluidity of the blood, protecting fragile capillaries from damage, exerting an antioxidant effect on free radices, and so prevent damage to cell membranes, and its inhibiting effect on platelet-activating factor:

Circulation Problems

Circulation problems in the arteries can lead to blood clots that in turn cause strokes and cardiac problems. By preventing blood clots through the inhibition of PAF, ginkgolide B can help to maintain a healthy circulation system that also help to maintain circulation in the very small capillaries that feed the brain.

Atherosclerosis

This is caused by hardening and blockage of the arteries, and one of the effects of ginkgo biloba is to soften the arteries, help to unblock them and to prevent plaque formation by its antioxidant effect on the free radicals that cause the plaque by oxidation of LDL lipids. This is particularly true of the Cerebral arteries.

Memory Impairment

The increased blood flow to the brain that GBE promotes can help to improve memory, although test are indicating that treatment has to continue for 6 weeks or more for it to be effective. Reduced blood flow to the brain is a common cause of memory impairment.

Alzheimer’s disease

Ginkgo biloba has been used in the treatment of the symptoms of this condition, although it cannot be cured. It is thought that the improved circulation in the brain makes best use of the unaffected brain cells, improving memory and cognitive thought.

Reynard’s Disease

This is a condition where the extremities fail to warm up after being exposed to cold, and is caused by poor circulation in the small capillaries in which the blood pressure is very low. They symptoms are numbness and pins and needles, and GBE helps to overcome this condition due to improvement in the circulation and protection of the capillaries by rendering them less fragile.

Vertigo

GBE can help to reduce the symptoms of vertigo such as nausea and dizziness. This is believed, once again, to be due to an improvement in blood circulation.

There are few doubts that ginkgo biloba extract improves the circulation, particularly in the micro-capillaries in the brain and extremities of the body, and also possesses antioxidant properties, both of which help to maintain and improve the memory, and that combined with its effect on the platelet-activating factor, most of the properties of GBE is due to its capacity to maintain and improve circulation, particularly through those blood vessels closest to the blood-brain barrier.


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DHA - Fish Oil
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Date: July 31, 2008 03:03 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: DHA - Fish Oil

A lot of research has been preformed over the past twenty years which has concluded that fats and cholesterol play a huge role in the development of heart disease, which happens to be the number one killer in the United States. It has been found that certain types of cholesterol in our blood can eventually lead to a buildup of plaque in the arteries, which restricts the blood supply to the heart and sets us up for a potential heart attack.

These researchers found it ironic when looking at the Greenland Eskimo, whose diet is rich in animal fat, but who is almost entirely free from coronary artery disease. Studies have proved that high levels of DHA and EPA that are found in the fish, seal, and whale diet of the Eskimo is what protects them from the heart disease that many people in the United States battle.

In order to improve cardiovascular health, DHA must performs many tasks. Increased DHA and EPA levels have been shown to lower total serum cholesterol. It has also been shown to selectively lower LDL cholesterol while elevating protective HDL cholesterol. Additionally, DHA and EPA supplementation lowers triglycerides. In terms of heart health, these omega-3s also reduce the tendency of platelets to clump and adhere to blood vessels and the blood vessels themselves to constrict.

Although diets that are high in fat content are believed to be potential risk factors for the development of certain types of cancer, especially breast cancer, the rates for some common cancers are relatively low among the Eskimos of Greenland and Alaska even though they have a high fat intake. Studies preformed to look into this fact concluded that the type of fat consumed may be important in determining cancer incidence, rather than just the overall fat intake.

DHA and EPA consumption suppresses the formation of a lot of leukotrienes, which are compounds that affect many different body systems. These leukotrienes stimulate bronchial contraction and are strongly associated with asthma, as they stimulate the production of mucus, affect Cerebral circulation, and are powerful pro-inflammatory agents. To sum it up, leukotrienes can contribute too several severe health conditions, so consuming DHA and other fatty acids, have shown to reduce the production of leukotrienes by as much as seventy-five percent. Also, supplementation causes immune and inflammatory responses to be greatly diminished, which is especially important for immune response disorders such as rheumatoid arthritis and inflammatory bowel disorder.

Unless people are eating a good amount of fatty fish and other sea foods daily, it is likely that both adults and children are deficient in DHA. To ensure the proper amount of DHA in the most effective way, one should take DHA in supplement form. Research has shown that consuming DHA exclusively from fish oil may have some drawbacks, specifically the taste of fish.

Fish oils that contain both DHA and EPA are now available in capsule form, which allows one to avoid the issue of taste. For those who prefer to have their supplements from a plant source, microalgae, the food source of fish, is a great source of DHA. This source can be used by both vegetarians and individuals on low-fat diets, both of whom are extremely vulnerable to having a lower dietary DHA level.

Also, if you are having trouble with fish oil softgels give vectomega dry fish oil a try. vectomega is a tablet form of fish oil you can take once daily to get your needed DHA and EPA to enhance your health.



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A Periwinkle Extract Vinpocetine May Promote Cerebral Blood Flow
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Date: December 01, 2007 09:05 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: A Periwinkle Extract Vinpocetine May Promote Cerebral Blood Flow

Periwinkles form the plant genus Vinca, of which the lesser periwinkle and the greater periwinkle are the two members. They are also a form of dogbane, known for its alkaloid properties. Periwinkles are of interest to the medical profession due to their biosynthesis of a number of alkaloids that are used to protect themselves from bacteria and are also toxic to the herbivores that would otherwise eat them.

Many other plants produce alkaloids, perhaps the best known being poppy, that produces the alkaloid opium that is the precursor to heroin. The alkaloids of the periwinkle, however, have a much more beneficial use for mankind in their action on certain types of cancer such as Hodgkin’s disease, and also on the flow of blood to the brain.

The components of the periwinkle include vinblastine, which is used in the treatment of Hodgkin’s lymphoma, and it is the only plant known to produce the alkaloid, although only in very small quantities after synthetic seeding. This involves introducing modified tryptamines to the plant so that they produce the desired alkaloid, although only in quantities of 0.002% of the weight of the plant. Although small, this is still less expensive that synthesizing the alkaloid in a chemical plant rather than a biological one!

Chemists are now seeking more readily synthesizable alternative forms of the alkaloid that have the same effect, again using the periwinkle as a botanical chemical factory to provide them with a lead as to possible synthetic routes. However, it is for the application of another alkaloid of this amazing little plant that we are more concerned with here.

In addition to vinblastine, the periwinkle produces the alkaloid vincamine, a type of tryptamine that can be extracted from the leaves of the lesser periwinkle, the Vinca minor. This periwinkle has been used through the ages as an invigorating tonic and as an astringent to treat bleeding gums and sores in the mouth. Vincamine promotes the aerobic glycolysis that is essential to Cerebral health.

Normal glycolysis, or the conversion of glucose to energy in the mitochondria of the cells of the body, occurs best in the absence of oxygen (anaerobic glycolysis). However, the brain produces up to and over 90% more energy through aerobic glycolysis in the presence of oxygen than through anaerobic. Hence one of the needs for such a rich supply of oxygenated blood being needed by the brain. As people grow older, or their brain tissue becomes damaged, then the supply of blood can be reduced and more and more anaerobic glycolysis is switched on. This results in an increasing loss of brain energy and hence brain function. Vincamine can reverse this effect, or at least maintain the status quo, and so enable people to maintain their brain function for longer.

It is also what is known as a vasodilator, and dilates the blood vessels in the brain allowing a greater blood flow. It is known to be beneficial in relation to tasks requiring focused concentration such as mathematical problem solving, and has also been found effective in the treatment of people with poor memory.

Vinpocetine (ethyl apovincaminate) is a derivative of vincamine, obtained by slightly modifying the molecule to produce a commercial form of the alkaloid. This possesses all of the beneficial effects of its precursor, including its positive effects on memory, believed to be due to the stimulation of serotonin production that improves the rate at which the brain can process information. Tinnitus, or ringing in the ears that has severely reduced the quality of life of so many people, can also be treated with vinpotecine.

Its vascodilation effect is thought to be through its action as a phosphodeaterase 1 (PDE1) inhibitor that results in an improvement in the plasticity of neurons. The mechanism is complex, but the end result is an improvement in the cognitive abilities of the subject. This is supplemented by the effect of vinpocetine on the calcium levels in the blood vessels. This renders them more plastic in much the same way that some anti-hypertension treatments work to reduce blood pressure by increasing the plasticity of the blood vessels by modification of their calcium levels. It can also reduce the viscosity of the blood through its action on the “stickiness” of leucocytes and so allow the blood to run more freely through the capillaries of the brain.

These effects have been demonstrated through double blind studies, and there is little doubt that vinpocetine helps to maintain a healthy Cerebral circulation. So let’s have a recap on its various effects, and then finish with a summary of the conditions that the alkaloid can be used to treat or improve. The theory and biochemistry behind these effects is known, but is complex, but here are the major actions:

a) It improves blood flow by modifying the calcium content of the blood vessels and so improves their elasticity, hence allowing a freer movement of blood. In effect it helps the blood vessels to dilate easier.

b) It inhibits the enzyme PDE1 and by doing so helps to restore the elasticity of neurons in aging brain cells, allowing them to relax more and operate more effectively.

c) It promotes aerobic glycolysis, and so the rate at which the mitochondria of brain cells produce ATP (adenosine triphosphate) that is the chemical manifestation of energy.

d) It helps to maintain a good supply of glucose and oxygen in the brain to allow (c) to occur.

Not all of these may be separate effects, but the outcome is an improvement in conditions such as short term memory loss, dementia and other conditions associated with a reduction in the blood supply to the brain including Menière’s syndrome and vertigo. There is also evidence that it helps with hearing problems, macular degeneration of the eye, and fatigue.

It is a supplement that should be taken by the elderly to help with age-related memory problems, but has also been found to be beneficial in normal healthy people. The periwinkle extract Vinpocetine has been shown to have benefits, largely through an increase in the blood flow to the brain, and will be of use to anybody suffering from conditions that can be related to a deficiency in their Cerebral blood supply.



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High Potency Premium Fish Oil for Adults or Children.
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Date: June 05, 2006 03:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: High Potency Premium Fish Oil for Adults or Children.

Fresh Catch Healthy Adult

Fresh Catch® Healthy Adult formula is a pure and pristine source of molecularly distilled, pharmaceutical grade fish oil formulated with the ideal dose and ratio of highly concentrated EPA and DHA omega-3 for the vibrant health and energy of healthy adults. Meet’s the American Heart Association’s recommendation of 2-to-4 grams of EPA and DHA.

Fresh Catch Healthy Adult 50+

Fresh Catch® Healthy Adult 50+ is a pure & pristine source of molecularly distilled, Pharmaceutical grade fish oil formulated with the ideal dose and ratio of beneficial Omega-3 - EPA and DHA, to support vibrant health and energy in healthy adults 50 years of age and over. Meets the American Heart Association’s recommendation of 2-to-4 grams of EPA and DHA.

Fresh Catch Healthy Mom

Fresh Catch® Healthy Mom is a pure and pristine source of molecularly distilled, pharmaceutical grade fish oil formulated with the ideal dose and ratio of DHA and EPA to address the health and nutrition priorities of pregnant and lactating women.

Compelling research indicates that DHA, and omega-3 fatty acid found in fish, and provided in Barlean’s Healthy Mom – aids in the Cerebral and eye development that occurs during pregnancy and into infancy. Optimal levels of DHA in the bloodstream of pregnant and lactating women may be important to development of the brain and nervous system of the developing fetus and infant and possibly address post partum depression.

Fresh Catch High EPA-DHA

Fresh® Catch EPA-DHA concentrate is a pure and pristine source of pharmaceutical grade fish oil providing an ideal dose and ratio of highly concentrated EPA and DHA omega-3 to support overall vibrant health and well being – for your vibrant health and energy. Meets the American Heart Association’s recommendation of 2-4 grams of EPA/DHA daily.

Fresh Catch High EPA

Fresh Catch® Super High Potency EPA is a pure and pristine source of pharmaceutical grade fish oil providing highly concentrated EPA Omega-3 to support cardiovascular, joint, immune and colon health. – for your vibrant health and energy.

Fresh Catch High DHA

Fresh Catch® Super Potency DHA is a pure and pristine source of molecularly distilled, pharmaceutical grade fish oil providing highly concentrated DHA omega-3 to support memory, cognition and emotional well-being – for your vibrant health and energy.

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Benefits of Best Alpha Lipoic 35!
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Date: February 12, 2006 03:11 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Best Alpha Lipoic 35!

Benefits

Supports the Body’s Defense Against Free Radicals*

Recycles Antioxidant Nutrients such as Vitamin C and Vitamin E*
Helps Maintain a Healthy Blood Sugar Level when used as part of the diet*

Alpha-lipoic Acid––the "Ideal Antioxidant"
The antioxidant potential of a substance is based on a number of criteria, including:
1) Ability to quench specific free-radicals.
2) Ability to bind or "chelate" metal ions that can generate free radicals.
3) Supports function of other antioxidants.
4) Absorption/bioavailability.
5) Concentration in tissues, cells and extra cellular fluids.
6) Ability to function as an antioxidant in fatty and watery environments.


The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes.

As a team, ALA and DHLA come close to the ideal, for the following reasons:1,2,3
1) ALA is easily absorbed when consumed orally.
2) ALA is readily converted to DHLA in various tissues.
3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals.
4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions.
5) ALA and DHLA scavenge free radicals in fatty environments and watery environments.
6) DHLA recycles other important antioxidants.


DHLA-regenerates vitamin C, vitamin E and glutathione

Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants.

DHLA is an essential component in the interaction between these antioxidants.4 Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form.3,5 The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells.4 DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes.6 Evidence from animal studies suggests that DHLA protects the brain against free radical damage.7

Alpha-lipoic Acid and Blood Sugar

Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA.8 In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved.9 In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells.10



Safety

Suggested Adult Use: One to six capsules daily with food.

Alpha-lipoic acid is considered safe, and no adverse effects have been seen with long-term supplementation.1

Scientific References
1. Packer, L.. Witt, E., Tritschler, H. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995;19(2):227-50.
2. Suzuki, Y., et al. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Comms. 15(5):255-63.
3. Biewenga, G., Haenen, G., Bast, A. The pharmacology of lipoic acid. Gen. Pharmac. 29(3):315-31.
4. Serbinova, E. Maitra, I., Packer, L. The synergy between vitamin E and alpha-lipoic acid--–possible relationship against oxidative stress in vivo. Life Chemistry Reports 1994;12:17-21.
5. Bast, A. Haenen, G. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochimica et Biophysica Acta 1988; 963:558-561.
6. Kagan, V. et al. Dihydrolipoic acid––a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992;44(8):1637.
7. Prehn, J. et al. Dihydrolipoate reduces neuronal injury after Cerebral ischemia. J Cereb Blood Flow Metab 1992;12(1):78-87.
8. Jacob, S. et al. Enhancement of glucose disposal in patients with type-2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45(8):872-4.
9. Jacob, S et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology & Medicine 1999;27(3/4):309-14.
10. Estrada, D. et al. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-804.


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Benefits of Alpha Lipoic Acid
TopPreviousNext

Date: October 13, 2005 05:08 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Alpha Lipoic Acid

Benefits of Alpha Lipoic Acid

  • Supports the Body’s Defense Against Free Radicals*
  • Recycles Antioxidant Nutrients such as Vitamin C and Vitamin E*
  • Helps Maintain a Healthy Blood Sugar Level when used as part of the diet*

    Alpha-lipoic Acid––the "Ideal Antioxidant"

    The antioxidant potential of a substance is based on a number of criteria, including:
    1) Ability to quench specific free-radicals.
    2) Ability to bind or "chelate" metal ions that can generate free radicals.
    3) Supports function of other antioxidants.
    4) Absorption/bioavailability.
    5) Concentration in tissues, cells and extra cellular fluids.
    6) Ability to function as an antioxidant in fatty and watery environments.

    The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes.

    As a team, ALA and DHLA come close to the ideal, for the following reasons:1,2,3
    1) ALA is easily absorbed when consumed orally.
    2) ALA is readily converted to DHLA in various tissues.
    3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals.
    4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions.
    5) ALA and DHLA scavenge free radicals in fatty environments and watery environments.
    6) DHLA recycles other important antioxidants.

    DHLA-regenerates vitamin C, vitamin E and glutathione

    Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants.

    DHLA is an essential component in the interaction between these antioxidants.4 Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form.3,5 The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells.4 DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes.6 Evidence from animal studies suggests that DHLA protects the brain against free radical damage.7

    Alpha-lipoic Acid and Blood Sugar

    Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA.8 In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved.9 In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells.10

    Scientific References

    1. Packer, L.. Witt, E., Tritschler, H. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995;19(2):227-50.

    2. Suzuki, Y., et al. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Comms. 15(5):255-63.

    3. Biewenga, G., Haenen, G., Bast, A. The pharmacology of lipoic acid. Gen. Pharmac. 29(3):315-31.

    4. Serbinova, E. Maitra, I., Packer, L. The synergy between vitamin E and alpha-lipoic acid--–possible relationship against oxidative stress in vivo. Life Chemistry Reports 1994;12:17-21.

    5. Bast, A. Haenen, G. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochimica et Biophysica Acta 1988; 963:558-561.

    6. Kagan, V. et al. Dihydrolipoic acid––a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992;44(8):1637.

    7. Prehn, J. et al. Dihydrolipoate reduces neuronal injury after Cerebral ischemia. J Cereb Blood Flow Metab 1992;12(1):78-87.

    8. Jacob, S. et al. Enhancement of glucose disposal in patients with type-2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45(8):872-4.

    9. Jacob, S et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology & Medicine 1999;27(3/4):309-14.

    10. Estrada, D. et al. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-804.



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    Oral Chelation with EDTA
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    Date: October 03, 2005 03:00 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Oral Chelation with EDTA

    Oral Chelation with EDTA

    Cardiovascular Disease claims nearly 960,000 lives every year which is largely preventable and reversible.

    What does heart disease really do to your body? Atherosclerosis (Hardened arteries) is a systemic condition (runs through out the body, brain, lungs, kidneys, and legs) where blood vesels get blocked and clogged. The blockages that lead to atherosclerosis can occur not only in large vessels sugeons can manipulate, but in the smaller blood vessels as well. Its in the smaller blood vessels and capillaries that the oxygen exchange to the tissue takes place.

    You can protect the critical lifeline of oxygen that feeds and sustains the organs and tissues throughout your body including your heart. There is a treatment that moves plaque and restores blood flow throughout the entire arterial system, treating the micro as well as the macro vessels. Its called EDTA chelation, available in oral supplementation. Oral chelation is safe and inexpensive therapy for your Cardiovascular system, if your family has a history of cardiovascular problems, don’t hesitate to try EDTA!

    Traditional medicine uses one of two primary ways to open blocked arteries. The first is angioplasty, take a balloon and ream out the large arteries to clear blockages, there is a risk of heart attack or making the blockage worst, and this type of blockages usually return to normal size after a year. The second is cut away the blockage and put in new vessels usually stripped from your legs or other places in the body. If your doctor has recommended this second form of treatment you should be aware that mortality rate of this surgery is 4% - 10% and common side effects after the procedure is Cerebral dysfunction—memory loss and mental decline.

    EDTA can also treat heavy metal poisoning!

    Back in world war II, men who worked in battery factories and men who painted ships with lead based paints began coming down with lead poisoning from their high exposure in these jobs. EDTA seemed to safely and effectively remove lead from the body and cure lead poisoning.

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    UROVEX: BUTTERBUR EXTRACT Supports healthy urinary urge and frequency Promotes healthy ...
    TopPreviousNext

    Date: June 29, 2005 02:13 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: UROVEX: BUTTERBUR EXTRACT Supports healthy urinary urge and frequency Promotes healthy ...

    UROVEX: BUTTERBUR EXTRACT Supports healthy urinary urge and frequency Promotes healthy bladder control

    Fear—the fear of job loss, embarrassment in social settings, sexual frustrations and psychological stress. That’s what life is like for the nearly 30 million people in the United States who have concerns with bladder control. A burden at any age, bladder issues are highly prevalent in both genders but more common in women. Urinary urge and frequency occurs when the smooth muscle of the bladder contracts without warning. SOURCE NATURALS UROVEX BUTTERBUR is a patented standardized extract that supports healthy urinary urge and frequency. Further, it has been shown to help minimize the sudden urge to urinate, according to a human clinical trial. It has also been shown to support smooth muscle relaxation in animal studies. In vitro studies show that UROVEX BUTTERBUR may reduce bladder cell irritation by inhibiting leukotriene synthesis.

    What Goes On

    If you experience this circumstance, you probably have two of the following indicators: frequency of urination (usually more than 8 times in 24 hours), urgency (an immediate and strong urge to urinate) and leaking or involuntary loss of urine. Although the changes in urinary anatomy—the result of normal aging—do not cause urinary trouble, they do create a situation that allows this to occur more easily. Aging results in a reduced size of the bladder, producing a decreased bladder volume and a need for more frequent bladder emptying.

    Urination involves physiological processes within the urinary tract and the brain. Our brain normally suppresses the urge to urinate until we initiate urination. Neurons in the brain and in smooth muscle of the bladder involuntarily govern the detrusor (layered, smooth muscle that surrounds the bladder) muscle. This muscle contracts and relaxes based on the volume of urine in the bladder and the initiation of urination. The desire to urinate usually starts when the bladder has reached about half its physiologic capacity. This desire is suppressed by the Cerebral cortex until a suitable time and place has been chosen. Butterbur relaxes the detrusor muscle, which reduces pressure on the bladder and thus relieves the urge to urinate. Each capsule contains 50 mg of standardized butterbur, yielding 7.5 mg of the active ingredients petasin and isopetasin. Our extract has been specially processed to remove undesirable pyrrolizidine alkaloids found in some brands.

    Newest Research

    UROVEX BUTTERBUR EXTRACT has been shown in research to improve the sudden urge to urinate. In one study, 24 women were given butterbur for 8 weeks. After three weeks, 17 women reported a significant reduction of the frequency of urination. Before they began taking butterbur, urination intervals were 30 to 90 minutes, while three weeks later the intervals of 17 of the women were between 90 and 150 minutes. Butterbur is a perennial shrub native to Europe, northern Africa and southwestern Asia that has been used medicinally for centuries to maintain a healthful, active lifestyle. The use of preparations from butterbur has included promoting proper smooth muscle tone, including relief for painful menstrual cramps and other traditional uses.

    An All-Natural Solution

    Source Naturals is pleased to partner with your natural food product retailer to deliver this botanical treasure that is so effective in solving this often untreated problem. Look for Source Naturals UROVEX BUTTERBUR. It is the only patented butterbur product for bladder control and other traditional uses and is available in 12, 30 and 60 capsule bottles.

    References
    Wang, Guei-Jane et al. 2002. Ca2+ channel blocking effect of iso-S-petasin in rat aortic smooth muscle cells. European Journal of Pharmacology. 445(3) : 239-245. Brune, Kay et al. 1993. Gastro-protective effects by extracts of Petasites hybridus: the role of inhibition of peptido-leukotriene synthesis. Planta Medica 59 : 494-496. Bickel, Daniela et al. 1994. Identification and characterization of inhibitors of peptidoleukotriene- synthesis from Petasites hybridus. Planta medica 60 : 318-322. Thomet, OA et al. 2001. Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. Biochemical Pharmacology 61 : 1041-1047. Bauer, H.W. and U. Danesch. 1995. Therapeutische Aspekte in der Urologie mit Petadolex (Therapeutic aspects in the urology with Petadolex) Presse Symposium München 10/18/95.



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    REFERENCES
    TopPreviousNext

    Date: June 25, 2005 12:40 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: REFERENCES

    REFERENCES

    1Penelope Od y. The Complete Medicinal Herbal. ( New Yo rk : Dorling-Kindersley, 1993) 64. 2I. Hi n d m a rch and Z. Subhan. “The Ps yc h o p h a r - m a c o l o g i c a l Effects of Ginkgo biloba Extract in Normal Healthy Volunteers.” Int. J. Clin. Pharmacol Res., (1984), 89-93. 3B. Gebner and M. Klasser. “Study of the Long-Term Action of Ginkgo biloba Extract on Vigilance and Mental Pe rformance as Determined by Means of Qu a n t i t a t i ve Pharmaco-EEG and Psychometric Measurements.” Arzneim-Forsch. (1985) 35, 1459-65. 4James Brady MD. “A Scientific Herb for Symptoms of Aging.” Doctor’s Best. (Laguna Hills, California). 5G. Vorberg. “Ginkgo biloba Extract (GBE): A Long-Term Study of Chronic Cerebral Insufficiency in Geriatric Patients.” C l i n i c a l Trials Journal. (1985) 22, 149-57. 6Michael Murray N.D., and Joseph Pizzorno, N.D. Encyclopedia of Na t u ral Medicine. ( Rocklin, California: Prima Publishing, 1991) 34. 7F. Juguet, K. Drieu and A. Piriou. “Decreased Cerebral 5-HT1A Receptors During Aging: Re versal by Ginkgo biloba Ex t r a c t , ” J . Pharm. Pharmacol. 1994 Apr. 46(4): 318-8. 8Ody, 64. 9Today’s Herbs, “Ginkgo.” (Provo, Utah: Woodland Health Books, September, 1992) 49. 10Today’s Herbs, 50. 11 F. Hoffmann, C. Beck, A. Schutz and P. Offermann. “Ginkgo Extract EGb 761 (tenobin)/HAES versus naftidr o f u ry l ( Du s o d r i l ) / Haes. A Randomized Study of Therapy of Su d d e n Deafness.” Laryngorhinootologie. 1994 March 73(3): 149-52. 1 2Rita Elkins. The Complete Home Health Ad v i s o r. ( Pl e a s a n t Grove, Utah: Woodland Books, 1994) 233. 13N. Kobayashi, R. Suzuki, C. Koide, T. Suzuki, H. Matsuda and M. Kubo. “Effect of Leaves of Ginkgo biloba on Hair Regrowth in C3H Strain Mice.” Yakugaku-zasshi. 1993 Oct. 113(10): 718-24. 14R. Kaezelmann and F. Kade. “Limitation of the Deterioration of Lipid Parameters by a St a n d a rd i zed Ga r l i c - Ginkgo Combination Product: A Multicenter Pl a c e b o - C o n t rolled Do u b l e - Blind St u d y. ” Arzneimittelforschung. 1993 Sept. 43(9): 978-81. 15A. Tamborini, and R. Taurelle. “Value of Standardized Ginkgo biloba Extract (EGb 761) in the Management of Congestive Symptoms of Premenstrual Syndrome.” Review Gynecol. Obstet. 1993 Jul-Sep 88(7-9): 447-57.



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    Migraine Headaches and Ginkgo
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    Date: June 25, 2005 12:02 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Migraine Headaches and Ginkgo

    Migraine Headaches and Ginkgo

    Because ginkgo helps to promote proper Cerebral circulation, it may be effective in some cases of migraine headaches. Migraines are believed to be the cause of a malfunction in vasodilation and constriction of blood vessels in the brain. By heightening blood flow and oxygenation of brain tissue, this neuro-vascular disorder may be alleviated or even prevented. More research is required to establish a firm scientific link between migraines and ginkgo.

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    Alzheimer’s Disease and Ginkgo
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    Date: June 25, 2005 11:26 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Alzheimer’s Disease and Ginkgo

    Alzheimer’s Disease and Ginkgo

    Concerning Alzheimer’s disease, ginkgo has been shown to normalize the acetylcholine receptors in the brain of aged animals which results in an increased transmission of nerve impulses. Alzheimer patients experience a decrease in these very functions.

    Clearly, test results have repeatedly shown that ginkgo has a positive effect in geriatric patients who have already experienced a deterioration of their mental performance. For this reason, it should be considered a viable treatment option in cases of Alzheimer’s disease and senile dementia. It is important to realize that it appears the ginkgo works more effectively in delaying the mental demise that occurs in the initial stages of Alzheimer’s disease. Once the disease is well established, the effects of ginkgo are minimized. On the other hand, if mental deterioration is due to a circulatory insufficiency, ginkgo therapy can help to reverse the condition.

    Laboratory tests performed on aged rats showed that ginkgo extract works to protect neuronal membranes in the brain. In addition, these tests also showed that the herb has a restorative effect which can help to pre vent the decrease in Cerebral receptors that occurs with aging.7

    Double-blind studies on groups of elderly subjects have confirmed that using ginkgo before presenting tests which required mental p rocessing significantly shortened the time required to process the material, which facilitated a speedier transference of information. Combining ginkgo with panax ginseng had similar results. Tests showed that this combination has a favorable effect on both learning and memory in aged individuals.

    Perhaps the most exciting biological potential ginkgo has is the possibility that it may pre vent the onset of certain age-re lated disorders if taken early enough. Research suggests that it may offer significant protection agains t the development of mental deterioration and strokes. In other words, the diminished mental function which routinely accompanies aging could be significantly prevented with ginkgo therapy.

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    Treating and Preventing Age-Related Mental Disorders
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    Date: June 25, 2005 11:24 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Treating and Preventing Age-Related Mental Disorders

    Treating and Preventing Age-Related Mental Disorders

    Ginkgo biloba may be of great value in cases of age-related mental dysfunction including senility, Alzheimer’s disease and diminished memory. In Paris, P. R. Michil conducted a double-blind study in which 50

    patients with moderate senile dementia were given either ginkgo or a placebo. Patients treated with ginkgo extract showed a significant improvement in their mood, sociability, and vigilance. Senility in the elderly is frequently the result of insufficient blood and oxygen flow to brain cells. Anytime this type of insufficiency occurs, short-term memory loss, ve rtigo, headache, malaise or depression can result. An extract derived from ginkgo leaves offers significant hope to anyone who suffers from diminished blood flow to the brain.

    In another large open trial involving 112 geriatric patients who suffered from inadequate Cerebral blood flow, 120 mg. of ginkgo biloba extract was administered. The results showed a significant regression of pre-existing symptoms.5 What this study implies is that so-called “age - related disorders,” including senile dementia, may be caused by reduced blood flow to the brain rather than the actual degeneration of nerve cells. Ginkgo appears to increase oxygen utilization in brain tissue, which also enables neural cells to metabolized sugar more effectively.6

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    Increased Brain Power and Memory with Ginkgo
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    Date: June 25, 2005 11:23 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Increased Brain Power and Memory with Ginkgo

    Increased Brain Power and Memory with Ginkgo

    Ginkgo’s ability to enhance cognitive function is becoming common knowledge. Boosting the capability of the brain to record information, communicate ideas or recall concepts can all be enhanced by taking ginkgo biloba therapeutically. Evidently, providing a better oxygen supply to brain cells is ginkgo’s primary neural action. The brain is the body’s most sensitive organ to oxygen deprivation. Today, more than ever, the effects of smoking, alcohol and stress in general can diminish brain function and compromise mental alertness. Ginkgo has demonstrated over and over that it can make a significant difference in memory retrieval, fact retention and problem solving.

    One of the most impressive aspects of ginkgo is its ability to stimulate circulation and oxygen flow to neural tissue, there by improving cognitive functions and memory. In test cases when ginkgo has been administered, an increase in cerebro-circulation has been noted in both healthy or diseased brain tissue. What makes this finding particularly relevant is that other circulatory enhancers, whether natural or synthetic do not usually possess this capability.

    In addition, ginkgo increases oxygen transport at the blood-brain barrier site, while inhibiting the permeability of toxins into brain tissue. As well as boosting blood supply to the brain, ginkgo has demonstrated the ability to increase the rate at which information is transmitted at the nerve cell level.2

    In a double-blind study, one group of healthy young women received ginkgo extract, and the other was given a placebo. A memory test was administered and the reaction time in those women who had taken the ginkgo improved significantly. These findings corresponded with EEG tracings which showed increased brain wave activity.3

    Short-term memory and basic learning rates can be statistically improved by using ginkgo. Ginkgo’s ability to enhance memory may also be helpful for epileptics who take anticonvulsants. Typically, an anticonvulsant can impair memory function, making it difficult to retrieve names or numbers from memory banks. In addition, although research is lacking, because ginkgo stimulates brain function, it may help to inhibit improper discharging of electrical impulses which is the primary cause of seizures in epileptics. Ginkgo is rapidly gaining an impressive reputation as a brain enhancer. It has demonstrated its capability to improve memory, mental efficiency and the ability to concentrate. It has also been shown to reduce anxiety, headaches, tension, vertigo, and age-related Cerebral disorders. Anyone who has suffered a stroke should look into the possible benefits of ginkgo to amplify mental function and clarity.

    Considerable research on ginkgo conducted in Eu rope has confirmed that ginkgo does indeed facilitate better arterial circulation as well as improve electrical transmission in the nerves. The latter function also contributes to improved oxygenation and nutrition to the brain.4 Ginkgo is now accepted as a brain booster which improves memory, mental efficiency, cognitive function, communication, orientation and the ability to concentrate. Recently, the notion of using ginkgo for learning disorders has received some attention. Forthcoming research on the subject will help to clarify its potential for treating such conditions.

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    Herbal Forms
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    Date: June 25, 2005 10:52 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Herbal Forms

    Herbal Forms

    Extract: An extract made from ginkgo leaves is available in Europe and is used for Cerebral arteriosclerosis in peripheral circulatory disorders of the elderly.

    Tincture: Ginkgo tincture is often combined with other herbs such as periwinkle and used for circulatory problems and venous disorders.

    Infusion: Infusions of ginkgo are used for arteriosclerosis, varicose veins and hemorrhoids.

    Capsules: Powd e red forms of ginkgo can be used to enhance brain function and memory.

    Storage: Keep in a dark container in a cool, dry environment.

    Regulatory Stauts:
    U.S.: none
    U.K.: none
    Canada: none
    France: over-the-counter drug status
    Germany: over-the counter drug status

    Recommended Usage: Ginkgo should be taken in normal dosages and, if possible, at the same times eve ry day. In the case of ginkgo, taking it consistently for 12 weeks is recommended. Although injections of Gingko have sometimes been used, oral ingestion of a tablet or capsule is therapeutically effective. More advanced p reparations of ginkgo make it possible to obtain higher concentrations of flavoglycosides in smaller amounts of extract.

    Safety: Ginkgo extracted from the leaves of the ginkgo tree is considered nontoxic and is virtually without side-effects. It can be safely used with other supplements without interaction and has no reported toxicity. In rare cases, some gastric upset or incidence of headache or skin rash have occurred, which may indicate that the individual is allergic to the substance. The fruit pulp of ginkgo can produce seve re contact dermatitis and other allergic reactions. The leaf extract of ginkgo is usually the only form that is available and is extremely safe.

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    Improove Memory ...
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    Date: June 09, 2005 05:49 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Improove Memory ...

    Mesmerizing Memory by Cal Orey Energy Times, January 1, 1999

    In the 60s, the same rock 'n' rollers who belted out "One pill makes you larger and one pill makes you small," often espoused the belief that certain pills could expand the mind. While counter-culture pill purveyors were pilloried for their pill-popping claims, 90s nutritional research has uncovered a stash of supplements that may amplify mental improvement.

    Like a blues singer bending a high note, researchers are now humming with dramatic assertions that certain nutritional supplements can sustain and enhance concentration and memory function. For instance, studies reveal possible benefits for cognitive powers from vitamin C, magnesium and Ginkgo biloba. A recent report in the Journal of the American Medical Association (JAMA 278:1327-1332) said that an extract of Ginkgo biloba "can stabilize and, in some cases, improve the cognitive function and social behavior of demented patients."

    A researcher in the Proceedings of the National Academy of Sciences noted that a daily dose of vitamin E may "help protect the brain and its memories from the ravages of time." And the beat goes on: other evidence indicates that zinc, iron and boron may pump up short-term memory attention span and cut the time it takes to perform mental tasks.

    Neuronutrients
    Neuronutrients-mentally helpful vitamins, minerals, fatty acids, amino acids and trace elements-offer an exciting key to keeping mental functions from succumbing to the degenerations of aging and disease. According to Dharma Singh Khalsa, MD, author of Brain Longevity (Warner Books) and an energetic campaigner for mental fitness through nutrition and exercise, vitamin E "can not only prevent deterioration of the brain, but actually reverse an important element of deterioration." Dr. Khalsa describes vitamin E as one of the most potent antioxidants, a fighter of the electrically charged free radicals that attack and break down cell membranes and nerve endings.

    Lester Packer, PhD, professor of molecular and cell biology at UC Berkeley, told a joint 1996 United Nations-World Health Organization conference on Aging that "there is a growing body of evidence indicating that the free radical theory of aging and aging-related disease is valid," and that dietary and supplemental antioxidants can help fight illness and mental deterioration.

    Vitamin E and other memory aids are believed to protect brain chemicals called neurotransmitters, "the ferrymen of the brain's communication system," that influence concentration and memory. Experts say that sustaining the level of these nerve chemicals in the brain can potentially improve all mental processes.

    Brain Well-Being
    "Your brain is intricately bound up with your physical state of well-being and is, therefore, vulnerable to any kind of physical abuse, especially that of chemical or substance abuse," report Thomas H. Crook III, PhD, and Brenda Adderly, MHA, co-authors of The Memory Cure (Pocket Books).

    Too much alcohol, for example, commonly causes progressive mental decline, according to Secrets of the Superyoung (Villard) by David Weeks and Jamie James. The authors also point out that "the memory tends to worsen noticeably after 15 years of alcohol drinking, and much sooner in people who go on massive binges."

    "The effects of cigarette smoke are subtler because the poisonous effects of carbon monoxide in each puff are temporarily offset by the alerting effects of the nicotine," they add. Can't remember the name of that singer cavorting in a music video? Tests have shown that smokers are worse at connecting peoples' names to their faces than nonsmokers.

    Cognition Ignition
    A first step in beginning your brain-boosting regimen consists of intensified intellectual activity, insists Rebecca Rupp, writer of Committed to Memory: How We Remember and Why We Forget (Crown): n Keep working: The mental challenges and social interactions of a job prevents lapses in the brain's synapses.

    n Learn something new: A second language, musical instrument, or unique puzzles and games keep neurons working like new.

    n Turn off the TV: Read. Studies show that passively watching TV requires less concentration than eating cereal. Mental rejuvenation also requires physical activity. Exercise increases oxygen flow to the brain, which supports memory, concentration and cognition. One study has shown that exercise significantly brightened the moods of middle-aged and older women, regardless of whether they were pre- or post-menopausal, with or without hormone replacement therapy.

    Supplemental Brain Help
    As you provide for your physical and mental vitality through healthy exercise and diet, you can augment your regimens with other supplements that research has shown to boost brain power.

    Antioxidants, including the previously mentioned vitamin E (You haven't forgotten vitamin E already, have you?), provide crucial help for vigorous Cerebral function. The free radicals created by tobacco smoke, air pollution, ultraviolet light and certain carcinogenic chemicals deconstruct cell membranes and may foster microscopic brain cell havoc. Antioxidant enzymes convert free radicals to more neutral, benign substances and nutritional antioxidants can neutralize free radicals by linking up with them.

    Vitamin C, a brainy antioxidant all star, performs so well that, according to Dr. Khalsa, its levels in the brain are almost 15 times higher than in other parts of the body. This nutrient, he asserts, aids mental and physical longevity. In a UCLA study, people who ingested at least 300 mg of vitamin C daily lived more than six years longer than those who ingested less.

    Mental Fat
    As a brain protector, selenium ranks high. Your brain consists of about 60% fat and selenium is a master at restricting detrimental fat oxidation. At the same time, zinc takes part in antioxidant processes that quell free radicals and strengthens neuronal cell membranes, protecting nerves from damage.

    Added to this mix, magnesium also scavenges free-radicals, according to Dr. Khalsa. Plus, experts recommend grape seed extract (phytochemicals that protect a wide range of cellular structures) to safeguard nerve cells and mental capacity.

    B Vitamins for the Mind
    John W. Rowe, MD, president of Mount Sinai Hospital and School of Medicine in New York and author of Successful Aging (Pantheon) states that "there is a significant relationship between blood levels of folic acid and vitamins B12 and cognitive decline." In other words, these vitamins seem to be necessary to eliminate a protein called homocysteine, which has been implicated in the development of coronary heart disease and cognitive problems. (Support for Dr. Rowe's conclusion appeared in the American Journal for Clinical Nutrition 63-306.)

    Iron Mind
    Iron also may strengthen memory. Since iron is involved in distributing oxygen to brain cells (and every other cell in the body), when you lack this mineral you may find it hard to concentrate. In the early 1990s, Harold Sandstead, MD, professor of preventive medicine at the University of Texas, discovered that women whose diets lack zinc and iron experienced more difficulties on standard exams than women with an adequate dietary supply. In his study of women aged 18 to 40, Sandstead found that giving these women more zinc and iron raised their scores on memory tests and average of 20%.

    Boron plays a crucial part in mental function. Scientists at the USDA's Human Nutrition Research Center have linked boron deficiencies to chronic lethargy and fatigue. In brain studies, they found that the electrical activity of the gray matter in the boron deficient indicated increased drowsiness and mental sluggishness.

    Huperzine Boost
    Borrowed from Chinese folk medicine, Huperzine A (HupA) recently has attracted attention from researchers who credit it with enhancing cognitive function and helping folks suffering from disease-related dementia. HupA is an extract of the club moss Huperzia serrata and has been used for centuries in China to treat fever, inflammation and, most recently, dementia. Dr. Alan Kozikowski, professor of chemistry in the neurology department at Georgetown University's Drug Discovery Program, a researcher who first synthesized HupA and studied it extensively, reported in the Journal of the American Medical Association (JAMA, 277 (10):776-March 1997), that HupA is safe, having been used to treat 100,000 people in China.

    HupA basically protects the brain from free radical damage (due to low levels of antioxidant defenses) and maintains or enhances crucial neurotransmitter action. More specifically, HupA helps reduce the breakdown of acetylcholine, the vital neurotransmitter, and makes this substance more bioavailable. In addition, HupA helps make choline accessible to the brain for the synthesis of acetylcholine, according to a study in Neuropharmacology (30, 1991: 763-768).

    Normally, the brain manufactures sufficient levels of the chemical phosphatidylserine, a lecithin-derivative that helps boost neurotransmitter release, but deficiencies of vitamin B12 and folic acid, or of essential fatty acids, may retard that production. Low levels of phosphatidylserine in the brain are related to impaired mental function and depression in the elderly. Scientists reporting in Aging (5, 1993; 123-33) describe "good results" using phosphatidylserine in the treatment of age-related cognitive ills.

    Ginkgo Brain Power
    Researchers also have demonstrated that Ginkgo biloba extract (GBE) increases brain function mostly by boosting acetylcholine receptors and the transmission of nerve impulses, with no significant adverse reactions. GBE is effective not only for folks with Alzheimer's; it also helps when mental function is impaired by vascular deficiencies or depression. Keep in mind that experts believe that GBE requires about 12 weeks of supplementation to reach optimal effectiveness.

    Another ingredient in what seems like an alphabet-soup of brain nourishment is DHA (docosahexaenoic acid), an omega-3 fat essential for normal brain function. Researchers met recently at The New York Hospital-Cornell Medical Center's Nutrition Information Center to discuss "Keeping Your Brain in Shape: New Insights into DHA." Their findings revealed links between low levels of DHA and Alzheimer's, depression, memory loss, attention-deficit/hyperactivity disorder (ADHD) and certain behavioral traits including aggression and hostility.

    Mostly Fat
    Since so much of the brain is fat, material like DHA forms the building block of brain tissue and the primary structural fatty acid in its gray matter. Although it is critical for mental and visual well being, the average American's consumption of DHA has declined since we're eating less of DHA's dietary sources: animal organ meats and eggs.

    Researchers from the National Institutes of Health point out, however, that fish is an excellent dietary source of DHA. In their studies, they discovered that depression rates in Japan and Taiwan, where fish ranks a top spot on the menu, are significantly lower than in North America and Europe.

    DHA also is crucial to the neurological development of children, according to findings published in Pediatrics (vol. 101, no. 1, January 1998). Researchers suggest that DHA-rich breast milk should be the model for infant formulas that enhance babies' neurological development. Scientists also have correlated some behavioral problems in children-ADHD, for example-to DHA deficiencies.

    If you are a vegetarian, or have other cause for concern about a potential lack of DHA in your diet, you can rely on dietary supplementation of DHA. Bruce J. Holub, PhD, of the University of Guelph in Canada provided vegetarians in his research project with DHA supplements over a 42-day period and substantially increased their DHA blood levels.

    The bottom line to enhanced mental performance is to take a balanced approach, says Robert Snider, MD, who specializes in preventive medicine in Massena, New York. "Maintaining brain power includes exercise, stress reduction and good nutrition." The message to keep in mind: Don't lose your nutritional balance or you could lose a piece of your peace of mind.

    Recommended Reading: & Brain Builders (Reward Books, 1995), by Richard Leviton.

    Brain Longevity (Warner Books, 1997), by Dharma Singh Khalsa, MD.

    Omega 3 Oils to Improve Mental Health, Fight Degenerative Diseases and Extend Life (Avery, 1996), by Donald Rudin, MD, and Clara Felix.

    Successful Aging (Pantheon, 1998), by John W. Rowe, MD, and Robert L. Kahn, PhD.



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    PHOSPHATIDYL SERINE (PS) - Maintain healthy cells ...
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    Date: June 04, 2005 11:08 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: PHOSPHATIDYL SERINE (PS) - Maintain healthy cells ...

    All we have ever known or will ever feel, begins and ends with the hundreds of billions of nerve cells that form our brain. Without them, there can be no experience; for us, nothing would exist. Our mind and personality, the sense of who we are, emanate from this immensely intricate system of nerves. The brain’s remarkable ability to perceive and perform, remember and learn, is severely challenged by today’s social and physical environment. These environmental factors accelerate the decline in nerve cell activity that normally occurs with age. Recent clinical research is revealing how previously unrecognized nutrients can strengthen the body’s natural defenses against age-related cognitive decline. Source Naturals is proud to present the latest breakthrough in nutritional support for the brain: PHOSPHATIDYL SERINE.

    Phosphatidyl Serine (PS) is a phospholipid which forms an essential part of every human cell, but it’s particularly concentrated in the membranes of nerve cells. Since the electronic messages that communicate and regulate every aspect of our lives travel along nerve cell membranes, the structural integrity of these membranes is imperative to our health. The nerve cell membrane is the site where molecules of sodium and potassium exchange electrons, causing the electrical impulse to be generated. This bio-electric current then travels along the membrane to trigger the release of neurotransmitters. These are the chemical messengers that cross synapses (gaps between nerve cells) to relay information to neighboring nerve cells. This sets other electrical currents in motion– along thousands of other nerve cells. This happens billions of times each second, and is how the brain and nerves coordinate and communicate with the rest of the body. PS has a very important function in the nerve cell membrane. As a key bio-structural molecule, PS provides vital support for the membrane proteins that enable nerve cells to communicate and grow.

    Regulating the Flow

    Unlike other cells in the body, nerve cells do not reproduce. Instead, they repair and rebuild themselves, using proteins called Nerve Growth Factor (NGF). Experiments verify that PS enhances the synthesis and reception of NGF, which tend to drop off radically with age.1 PS supplements enhance the Cerebral cortex’s output of acetylcholine, the neurotransmitter associated with our ability to think, reason, and concentrate. PS also stimulates the synthesis and release of dopamine, related to heightened states of attention.2 The brain’s response to stress also appears to be related to PS. When healthy young men were subjected to exercise-induced stress, those taking PS had a lowered stress response. This was measured by blood levels of ACTH, the pituitary hormone that triggers the adrenals to secrete the stress hormone cortisol.3

    Well-Tested

    Subjects taking PS showed increased levels of brain energy metabolism and scored higher on cognitive tests.4 Behavioral factors were also measured in elderly subjects; PS positively affected their mood states.5 Over 23 clinical trials have investigated the effect of PS supplements on more than 1200 human subjects, ages 40-93. Consistent and statistically significant results suggest that PS supports brain functions that tend to diminish with age.

    Wellness Redefined

    Nutritional research continually reveals new potentials for wellness. Source Naturals is committed to helping people achieve a fulfilling life, and a fully functioning nervous system is central to this aim. Source Naturals PHOSPHATIDYL SERINE can help support your body’s natural regenerative processes, keeping your brain healthy and vital for a long, long time. Experience the difference with Source Naturals PHOSPHATIDYL SERINE.

    References:
    1. Aporti, F., et al., 1986. “Age-dependent spontaneous EEG bursts in rats: effects of brain phosphatidylserine.” Neurobiology of Aging 7: 115-120. 2. Caffarra, P., and V. Santamaria, 1987. “The effects of phosphatidylserine in subjects with mild cognitive decline.” Clin. Trials J. 24: 109-114. 3. Heiss, W.D., et al., 1993. “Activation PET as an instrument to determine therapeutic efficacy in Alzheimer’s Disease.” Annals N.Y. Acad. Sci. 695: 327-31. 4. Monteleone, P., et al., 1990. “Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans.” Neuroendocrinol. 52: 243-48. 5. Nunzi, M.G., et al., 1990. “Therapeutic properties of phosphatidylserine in the aging brain.” In, Phospholipids: Biochemical, Pharmaceutical and Analytical Considerations (ed. I. Hanin and G. Pepeu). New York: Plenum Press.



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    Mega Mind - re-align your body systems ...
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    Date: June 03, 2005 05:24 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Mega Mind - re-align your body systems ...

    MegaMind

    Aging and nutritional imbalances can disrupt the multiple body systems that affect healthy brain function. The result: cognitive symptoms* such as forgetfulness, inability to focus, and mental fatigue. MEGAMIND™ is a Bio-Aligned Formula™ that helps align multiple systems: neurotransmitter production, antioxidant defense, energy generation, circulation, and myelin sheath generation. Complementary Formulations Source Naturals can help keep your mind sharp and alert. Use MENTAL EDGE® Bio-Aligned Formula for foundational support, or MEGAMIND, when memory symptoms* are severe. HIGHER MINDTM is an additional Bio-Aligned choice. Take these formulas alone or as the core of a program that includes additional ingredients such as DHA (NEUROMINS®), GINKGO-24™, PHOSPHATIDYL SERINE, VINCAMINE, and VINPOCETINE.

    In today’s complex world, we are bombarded with information. Our ability to process this massive input depends on how well we nourish the multiple body systems related to brain health. In addition, normal aging is associated with impairment of certain mental functions, according to the National Institute on Aging. The brain undergoes changes including functional decline in neurons important to learning, memory, planning, and other complex mental activities, as well as increased oxidative stress. In healthy people, these changes may result in varying degrees of age-related memory decline. Source Naturals can help, with a full line of cognitive support products.

    Mental Edge®: Bio-Aligned Formula

    MENTAL EDGE is a literal multivitamin for your brain. MENTAL EDGE supports production of neurotransmitters including acetylcholine, antioxidant defense, energy generation, stress response and myelin sheath generation. It features nutrients needed for production of neurotransmitters— chemical messengers in the brain’s communication system. One of the most important of these is acetylcholine, which is necessary for memory and muscle movement. MENTAL EDGE also contains antioxidants—vitamin C, ginkgo, DMAE, and zinc—to protect the neuron cell membranes where electrical signaling takes place. Adaptogenic herbs provide the brain with support and energy to deal with environmental stress. Energy-generating ingredients such as ginkgo and B-vitamins are vital to the high-powered functioning of your brain. Vitamins B-5 and B-12 are also important for formation of myelin, a substance that forms a protective insulating cover around certain nerve fibers and increases nerve impulse conduction.

    MegaMind™: Bio-Aligned Formula When memory symptoms* are severe, you may need a formula with extraordinary cognitive support. MEGAMIND addresses many of the same body systems as MENTAL EDGE, but does so with megadoses of brain nutrients, such as L-pyroglutamic acid and vitamin B-1 for neurotransmitter production. It also adds bacopa and the inhibitory neurotransmitter GABA to support neurotransmitter production, and higher potency vitamin B-12 for myelin sheath generation. Like MENTAL EDGE, MEGAMIND supports energy generation and antioxidant defense. MEGAMIND augments basic support for the brain’s immense energy requirements with higher potency vitamin B-1, and with one of nutritional science’s most advanced, high-tech nutrients, alpha-lipoic acid. Lipoic acid is also an antioxidant, as are gotu kola and grape seed. MEGAMIND also supports circulation with ginkgo and gotu kola.

    Mega Mind: Bio-Aligned Formula HIGHER MIND is another multi-system support formula, which features phosphatidyl serine, a structural component of nerve cell membranes, and the botanical vinpocetine. HIGHER MIND nourishes neurotransmitter production, cell membrane stability, energy generation, antioxidant defense and myelin sheath generation.

    Neurotransmitter Production: Bacopa, GABA, L-Glutamine, L-Pyroglutamic Acid, Taurine, N-Acetyl L-Tyrosine, Manganese, Vitamins B-1 & B-6

    Acetylcholine Production: Acetyl L-Carnitine, DMAE, Gotu Kola, L-Pyroglutamic Acid, Vitamin B-5

    Myelin Sheath Generation: Vitamins B-5 & B-12

    Energy Metabolism: Acetyl L-Carnitine, Ginkgo Biloba, L-Glutamine, alpha-Lipoic Acid, Calcium, Magnesium, Manganese, Potassium, Zinc, Vitamins B-1, B-2, B-3, B-5, B-6 & B-12, Biotin,Folic Acid

    Circulation: Ginkgo Biloba, Gotu Kola

    Antioxidant Defense: DMAE, Ginkgo Biloba, Gotu Kola, Grape Seed, alpha-Lipoic Acid, Zinc, Vitamin C

    Complementary Cognitive Support Products

    For additional support, you can supplement Source Naturals Bio-Aligned formulas with these single ingredient products: ACETYL L-CARNITINE and DMAE are both important to the synthesis of acetylcholine, a key neurotransmitter associated with higher cognitive functions, such as learning and memory. DHA (NEUROMINS®) is an omega-3 fatty acid that plays a significant role in Cerebral development, especially during fetal development and infancy. GINKGO is renowned for promoting blood flow to the brain. Source Naturals GINKGO-24™ is a standardized concentration of Ginkgo biloba leaves, yielding 24% ginkgo flavone glycosides and 6% terpenes (the key constituents). PHOSPHATIDYL SERINE is necessary for the health of nerve cell membranes, where electrical signaling takes place. These membranes are critical to information processing. VINCAMINE, an alkaloid obtained from the periwinkle plant, supports Cerebral metabolism by promoting blood flow and oxygen and glucose utilization. VINPOCETINE is a derivative of vincamine, shown in research studies to improve cognitive performance and alleviate the short-term memory loss that may accompany stress or aging.

    Lifestyle Tips for Cognitive Health: A Strategy for Wellness SM

    Eat Well: Recent research suggests that diets rich in beta-carotene and vitamins C and E help reduce memory problems, probably by lessening oxidative stress. And new animal research at the University of Toronto found that a high-fat diet slowed the ability of rats to learn new tasks. Use Your Brain: Learn a foreign language or new hobby, do crossword puzzles, read books, and cut back on TV. Scientists at Case Western found that people who were less mentally active in middle age were three times more likely to experience memory decline as they got older. Stay Active: Vigorous walking can improve mental processes in aging individuals, according to research. Aerobic exercise increases oxygenation and blood flow to the brain, resulting in improved memory, organization, and the ability to juggle intellectual tasks. Manage Stress: Longterm anxiety or depression can make a person more forgetful. Try to regulate stress, increase social contacts, and, if necessary, seek professional help. Get Organized: Make the most of your cognitive abilities, through the use of memory aids such as “to-do” lists, notes, or calendars.

    References
    Braquet, P. Ginkgolides-Chemistry, Biol., 1988. FAO/WHO Expert Committee (1994). Food and Nutrition Paper No. 57. FAO: Rome. 49-55. Heiss, W.D., et al. (1993). Annals N.Y. Acad. Sci. 695: 327-31. Passeri, M., et al. (1990). Int. J. Clin. Pharm. Res. X(1/2): 75-79. Simopoulos, Artemis P. (1991). Am J Clin Nutr: 54. 438-63. Vorberg, G., M.D. Clinical Trials Journal 22.2 (1985): 149-57.



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    Intimate Response - The Freedom to Change. Boost intimacy
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    Date: June 02, 2005 12:48 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Intimate Response - The Freedom to Change. Boost intimacy

    SENSUALITY AND MENOPAUSE. FOR MANY WOMEN THIS apprehensive milestone is foreshadowed by disquieting physiological changes. Its debut marks a transition period that can actually begin at age 40. Called pre-menopause, it usually lasts 3 to 6 years and is characterized by powerful hormonal changes with wide-ranging effects on a woman’s body. Her level of romantic passion is often influenced by these changes. Source Naturals is proud to announce ETERNAL WOMAN™ INTIMATE RESPONSE™. This herbal-safe, natural formulation may support a woman’s healthy vitality and vigor during pre-menopause.

    Healthy Circulation = Natural Vitality.

    Most women experience decreases in desire at one time or another. Activity levels, monthly hormonal changes, circulatory status, drugs such as oral contraceptives and anti-depressants, alcohol and emotional factors all may contribute to a woman’s passion. However, premenopause is something more. Hormones stimulate, affect and balance hundreds of processes during a woman’s monthly cycle. When their levels begin to fluctuate and decline during premenopause, the body’s internal balancing act is acutely influenced. The bloodstream is our “river of life” as it delivers oxygen and nutrients throughout the body. Maintaining adequate blood circulation is necessary to our health and vitality. INTIMATE RESPONSE contains these supportive herbs and nutrients: yohimbe, epimedium, Ginkgo biloba, Panax ginseng, and L-Arginine.

    The Nitric Oxide Connection.

    L-Arginine is the primary amino acid t hat the body uses to make nitric oxide. It is nitric oxide that helps the muscle tissues surrounding a blood vessel to relax, allowing more blood to flow to the organs. Panax ginseng is a highly valued botanical traditionally utilized as an energizing tonic. In use for thousands of years in China, its main active constituents are the ginsenosides. Ginkgo extract is traditionally the premier herb for supporting blood flow in the circulatory system. Pregnenolone is the starting point from which all sex hormones are produced internally. Yohimbe is an African herb that has traditionally been used for more than 100 years. It supports peripheral blood vessels. Epimedium and dong quai are highly valued blood tonic herbs in traditional Chinese medicine used to support circulation and “life essence.” Vitamin B6 and folic acid support proper blood flow and healthy arteries by reducing levels of homocysteine in the bloodstream.

    The Healthy, Herbal-Safe Response.

    INTIMATE RESPONSE is a remarkable combination of herbal-safe, gentle ingredients that may support healthy and normal circulation during pre-menopause. For the freedom to change™ naturally...choose INTIMATE RESPONSE by Source Naturals.

    References:
    Bush, P., et al. (1992). Biochemical and Biophysical Research Communications, 186(1), 308-314. Chatterjee, S.S. in: Effect of Ginkgo Biloba on Organic Cerebral Impairment (Agnoli, A, Rapin J.R., Scapagnini, V., Weitbrecht, W.V., eds) John Libbey, London, pp. 5-14 (1985). Chen, X. (1996). Clin Exp Pharmacol Physiol, 23(8), 728-32. Davis, S.R., & Burger, H.G. (1996). Journal of Clinical Endocrinology and Metabolism, Vol. 81(8), 2759-2763. Franken, D.G., et al. (1994). Arterioscler Thromb., 14, 465-470. Huang, K.C. (1993). The Pharmacology of Chinese Herbs, CRC Press Inc: Boca Raton, 91-92. Marcocci, L., et al. (1994). Biochemical and Biophysical Research Communication, 201(2), 748-755. Paick, Jae-Seung, & Lee, J.H. (1996). The Journal of Urology, 156, 1876-1880. Riley, AJ. (1994, May/June). BJCP, 48(3), 133-136. Roberts, E. (1995). Biochemical Pharmacology, 49(1), 1-16. Stamler, J.S. et al. (1993). The Journal of Clinical Investigation, 91, 308-318. Zumoff, B., et al. (1995). Journal of Clinical Endocrinology and Metabolism, Vol. 80(4), 1429-1430.



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    Higher Mind - Smart Nutrients for the Performance of a Lifetime...
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    Date: June 02, 2005 12:18 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Higher Mind - Smart Nutrients for the Performance of a Lifetime...

    Our adult years are the time to reap the fruit of an active, meaningful life – appreciated by family and friends who value our experience and knowledge. For some, however, their later years are clouded by a mental decline that erodes their capacity to enjoy life. More of us are becoming apprehensive about the future health of our minds. Will we still be able to communicate our needs as well as our wisdom? As science focuses its investigative might on the workings of the human brain, new findings suggest that it is possible to enjoy a vital, healthy brain and mind – well into old age. Based on compelling research, Source Naturals formulated HIGHER MIND. It contains the most important Neuroceuticals™ now recognized by nutrition scientists – including phosphatidyl serine, a natural nutrient that promotes cognitive function. The connection is clear: nourish your brain; enrich your life.

    To have a healthy, well-functioning brain and nervous system, we need the correct nutrients. Our diets must provide the necessary raw materials for nerve cells to grow, for the synthesis of neurochemicals, and for the maintenance of nerve cell membranes. Nutritional deficiencies can alter the brain’s metabolism, which is expressed by changes in perception and thinking, behavior and mood.

    Brain Cells – Issued at Birth

    Before birth, neurons (nerve cells) are created at the amazing rate of 15 million per hour. As infants, we have over 100 billion neurons, but this is the most we will ever have because – unlike most other cells in our body – nerve cells do not reproduce. A different strategy is used to replace the neurons that are naturally lost throughout life: nerve cells repair themselves and grow by extending branches of nerve fibers called dendrites (from the Latin word for tree). These are the communication links with other neurons that form the circuitry of the brain. A single neuron may be in contact with up to a hundred thousand others! When the density of this fragile organic communication network decreases, we experience a corresponding decline in mental acuity.

    Brain Cell Membranes

    The membrane is the working surface of a cell. It needs to be strong yet flexible, so the cell can maintain its integrity and be able to move and change shape. The membrane regulates the flow of nutrients into the cell and the removal of waste, plus controls the passage of molecular messages from outside the cell to its interior. Membrane ion pumps use a third of the cell’s energy just to maintain the correct ratio of sodium to potassium. In neurons, a rapid exchange of sodium and potassium ions across the nerve membrane is responsible for their unique ability to generate the electrical impulses that are the basis of all communication in the nervous system. As cells age, their membranes become less fluid and more rigid. Key membrane molecules called phospholipids are crucial to the health of neuron membranes, allowing the brain to maintain its youthful quality. The phospholipids in HIGHER MIND – especially phosphatidyl serine and phosphatidyl choline – are essential nutritional supplements for the aging brain.

    Phosphatidyl Serine – Key to Cognition

    For the past decade, researchers have been investigating the role in brain health of a remarkable neuroceutical, phosphatidyl serine (PS). This key structural molecule is integral to the matrix of fats and proteins that compose cell membranes. Although PS is found in all the cells of the body, its highest concentration is in nerve cell membranes. PS is rarely found in the foods we eat, so the body has to synthesize it, but the process is energy- intensive and becomes less efficient with age. Consequently, our levels of PS tend to decline as we get older. PS taken as a dietary supplement is well-absorbed, readily reaching the brain, where it helps create more effective, well-structured nerve cell membranes. The positive effects of PS supplementation have been demonstrated by 23 clinical studies with over 1200 human subjects, ages 43 to 90. Consistent and statistically significant results have confirmed the value of PS in improving age-related cognitive decline, as well as in improving behavioral aspects such as apathy and withdrawal.1 A major study concluded that for one particular measurable parameter of higher mental functions, PS recipients achieved scores of persons roughly 12 years younger.2 Nerve Growth Factor (NGF) is one of the most important proteins the body makes. It enables neurons to extend dendrites out to other neurons, allowing the brain to maintain an effective communication network. In experiments, PS enhanced the production and reception of NGF, which tend to drop off radically with age.3 The effects of PS at the cellular level are manifest in the performance of the brain as a whole. Subjects taking PS showed increased levels of brain energy metabolism. This enhancement corresponded to higher performances on cognitive tests.4

    The Chemistry of Thought

    Science now understands the role of neurotransmitters in regulating the body’s complex network of behavior. Neurotransmitters are the chemicals used by neurons to communicate with each other. Activated by a neuron’s electrical impulse, neurotransmitters travel between nerve cells, where they excite or inhibit (in various degrees) the electrical impulse in neighboring cells. One of HIGHER MIND’S key strategies is to improve the brain’s ability to produce and use acetylcholine, a key excitatory neurotransmitter. Acetylcholine is essential for both the storage and recall of memory, and partly responsible for concentration and focus. It also plays a significant role in muscular coordination. Patients showing cognitive decline may exhibit reduced ability to synthesize and utilize acetylcholine.5 The chemical building blocks of acetylcholine and other neurotransmitters are called precursors. The most important one for acetylcholine is DMAE (dimethylaminoethanol). This natural substance is found in various fish, such as anchovies and sardines. Supplements of DMAE (and phosphatidyl choline) promote increased levels of choline in the brain. Acetylcholine is created when an acetyl group is attached to the choline molecule, with the help of choline acetyl transferase (CAT), a key brain enzyme. Acetyl L-carnitine is an amino acid that activates this enzyme. Acetyl L-carnitine may also help reduce lipofuscin deposits in the brain because of its involvement in the metabolism of fatty acids.6 Lipofuscin is composed of oxidized fats and proteins; the brown “age spots” on the back of an elderly person’s hand are made of lipofuscin. The amino acid L-pyroglutamic acid sensitizes the acetylcholine receptor sites on a neuron membrane. A given amount of acetylcholine will then have a larger, more powerful effect. Studies have shown that supplements of L-pyroglutamic acid seem to enhance the ability to focus, remember, and learn.

    Total Nutrition for the Brain

    The neurotransmitters dopamine and noradrenalin are critical to motor coordination, motivation, concentration, and alertness. Like acetylcholine, their production tends to decline with age. The precursors and activators of dopamine and noradrenalin included in HIGHER MIND are the amino acids N-Acetyl L-Tyrosine and DL-phenylalanine (DLPA), plus folic acid, vitamins B-3, B-6, and C. DLPA is also a precursor to PEA, a neuroamine that has a stimulating effect on the brain. Glutamine is an amino acid precursor to glutamic acid, a major excitatory neurotransmitter involved in mental activity and learning. Glutamine acts as an alternative fuel source for the brain when blood sugar levels are low. It also helps the brain dispose of waste ammonia, which is a natural result of protein breakdown but is irritating to neurons even at low levels. GABA is a dietary amino acid which is also an inhibitory neurotransmitter. GABA works to calm and balance the mind, enhancing mental focus. Along with taurine, these two relaxing neurotransmitters provide a balancing influence to the other, excitatory neurotransmitters. Taurine is found in brain tissue more than anywhere else in the body. It has antioxidant properties and serves as a nerve cell membrane stabilizer, preventing excessive or erratic electrical activity in the brain.

    The Importance of Magnesium

    Magnesium must be present in adequate amounts in the synaptic gaps between neurons or the neurons become hyper-reactive: causing noises to sound excessively loud and emotional reactions to be extreme. Magnesium also activates a key enzyme responsible for maintaining cellular sodium- potassium balance, which is absolutely essential to the electrical activity of nerve cells, as well as to the existence of the cell itself. (Cells would burst if the sodium-potassium ratio were wrong.) Magnesium also helps relax Cerebral blood vessels and is important to the manufacture of ATP, the chief energy molecule of the brain. A buildup of aluminum has been found in the brains of some elderly. In 1989, the British medical journal Lancet published a study showing that drinking water with aluminum can increase the risk of damage by up to 50%. An abundant natural element, aluminum is now a common feature in our culture. It’s found in tap water, cookware, deodorants, beverage containers, baked goods, and of course as aluminum foil. In the brain, aluminum breaks down the structure of neurons – causing them to starve – by displacing magnesium from tubulin, a glycoprotein responsible for making microtubules. These tiny pipe-like structures within a neuron provide needed rigidity, as well as transport nutrients from the nucleus down the dendrites to the ends of the nerve cell. Magnesium malate is an excellent form of magnesium that ensures neurons receive this vital mineral.

    B is for Brain Vitamins

    HIGHER MIND also contains a high profile of B vitamins and other key nutrients that are often N A T U R A L S S O U R C E Strategies for Wellness SM ¤ lacking in older individuals. A deficiency in any of the B vitamins can alter nerve function and psychological well-being. Thiamine (B-1), known as the “nerve vitamin,” was first recognized because its deficiency caused beriberi, a degenerative nerve disease. Thiamine is part of the structure of nerve cell membranes and is important to the reparative process that neurons need to offset the stress of continual firing of the electrical impulse. Low amounts of thiamine can cause cell malnutrition in the hypothalamus, the brain’s memory center. 7 NAD and NADH, two coenzyme forms of Niacin (B-3), are the most plentiful coenzymes in the brain. They are essential to hundreds of enzymatic reactions, including ones that produce energy. NADH can stimulate the synthesis of key mood-elevating neurotransmitters. It is also one of the body’s most potent antioxidants. Pantothenic acid (B-5), cyanocobalamin (B-12), and folic acid are required to form the myelin sheath – the insulating covering of nerve fibers. A diet low in pantothenic acid has been shown to make test subjects emotionally upset, irritable, and depressed.7 A lack of B-12 can result in poor concentration and, in severe deficiencies, hallucinations. Pyridoxine (B-6) is precursor to over 60 enzymatic reactions and is involved in the synthesis of several neurotransmitters.

    Brain Power

    Brain cells almost exclusively burn glucose for their energy (other cells can also burn fat), and typically require 50% of all the glucose in the blood. Two B-like vitamins help in the utilization of glucose: PAK (pyridoxine alpha-ketoglutarate) may potentiate the effects of insulin and improve glucose utilization to the cells;8 Biotin is important for the transformation of glucose into energy in the brain. Lipoic acid and coenzyme Q10 are metabolic energizers that help produce ATP, the primary energy molecule in the body. Since the brain uses 20% of the body’s total energy supply, efficient ATP production is vital. Lipoic acid and CoQ10 are also powerful antioxidants that help regenerate other antioxidants in the body. The blood vessels feeding the brain become less efficient as we pass middle age. Since the brain depends on the bloodstream to deliver nutrients and oxygen and to remove waste, the quality of this blood flow is paramount to proper brain nutrition. Ginkgo biloba leaf extract has been shown in scientific studies to increase blood flow to the brain by helping vessels to dilate. It also promotes the smoothness and healthy integrity of blood vessel linings.

    For the Life of Your Mind Without proper nutrition, the brain will deteriorate; therefore strategies are needed to both enhance current brain function and protect it throughout life. Based on the latest scientific findings, Source Naturals HIGHER MIND is formulated with neuroceuticals that support the mental functions that tend to decline with age. They give your brain the nourishment it needs to integrate perception, memory, and learning into a more comprehensive awareness – so you can excel for a lifetime.

    References
    1. Palmieri, G., et al. (1987). Clin. Trials J. 24: 73- 83.
    2. Crook, T.H., et al. (1991). Neurol. 41: 644-49.
    3. Nunzi, M.G., et al. In Phospholipids: Biochemical, Pharmaceutical and Analytical Considerations (ed. I. Hanin and G. Pepeu).
    New York: Plenum Press, 1990.
    4. Heiss, W.D., et al. (1993). Annals N.Y. Acad. Sci. 695: 327-31.
    5. Passeri, M., et al. (1990). Int. J. Clin. Pharm. Res. X(1/2): 75-79.
    6. Kohjimoto, Y., et al. (1988). Japanese Journal of Pharmacology 48(3): 365-71.
    7. Philpott, William H. Brain Allergies: the Psychonutrient Connection. New Canaan: Keats, 1987.
    8. Passariello, N., et al. (1983). Int. J. Clin. Pharmacol. Ther. Toxicol. 21: 252-56.



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    DHA Neuromins - Feed Your Brain!
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    Date: June 01, 2005 11:59 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: DHA Neuromins - Feed Your Brain!

    Neuromins DHA

    In today’s society, “fat” has become a bad word. Our quest for good health has influenced many of us to drastically reduce our intake of fatty foods. But this dietary change has brought unintended consequences. As we’ve cut back on unhealthy saturated fats, we’ve also reduced certain “good” fats essential to our well-being. Few people realize how important fats are to a healthy brain. In fact, our brains are primarily fat, 60% by dry weight! And DHA, the most plentiful fatty acid in the brain, is crucial to brain health, from infancy to old age. Now DHA is available in a vegetarian source compatible with today’s trimmed-down lifestyle. Introducing: Source Naturals NEUROMINS DHA.

    The Building Block of the Brain

    DHA is shorthand for docosahexaenoic acid. This omega-3 long chain fatty acid is the primary building block of the brain and retina of the eye. The brain is 60% fat, and DHA is the most abundant fatty acid in the brain, comprising 25-35%. DHA is found in even greater concentrations - 50- 60% - in the retina. DHA is critical for infant development. Compelling research links DHA to the rapid Cerebral and eye development that occurs during pregnancy and in the first few months after birth. DHA passes through the placenta to the fetus during pregnancy, and to the nursing baby through breast milk. Optimal levels of DHA in the bloodstream of pregnant women and the breast milk of nursing mothers are crucial to babies. In fact, DHA’s presence in breast milk may explain why breast-fed babies have demonstrable IQ advantages over babies fed formula without DHA. An emerging body of research led an expert committee of the U.N.’s Food and Agriculture Organization/World Health Organization to recommend that DHA be included in infant formulas at levels comparable to those of mothers’ milk. Yet DHA levels in the breast milk of American women rank among the lowest in the world, and DHA is still not available in U.S. infant formulas.

    Supporting a Healthy Nervous System

    DHA’s benefits are not limited to infant development. Supplementation may be helpful to anyone with a low DHA intake, especially for supporting a healthy nervous system. DHA has been associated with optimal memory function, visual acuity, and maintaining a positive mental state. DHA is an integral component of all membranes with electrical activity. The cells in our brain, retina and other parts of the nervous system have a complex network of connecting arms that transport electrical messages throughout the body. DHA’s presence in nerve cell membranes is critical because this is where messages are transmitted. It is at the membrane that nerve cells generate the electrical impulses that are the basis of all communication in the nervous system. Without the necessary fatty acids, this communication system can break down or become less effective. DHA supplementation may be especially important as we grow older. The body’s ability to synthesize DHA, which is very limited in all human beings, may decline even further with age. Research suggests that aging interferes with the activity of delta-6-desaturase, the enzyme involved in the conversion of omega-3 fatty acids into DHA. Elderly people with inadequate or DHAdeficient diets may benefit from a supplementary source of DHA.

    Insufficient in Today’s Diet

    Because human beings cannot adequately synthesize DHA, most of it is obtained from our diets. The richest sources are red meats, animal organs and eggs - among the first foods to be eliminated by people concerned about fat intake. Today, the average American is getting less DHA from food, and vegetarians, vegans, and people on lowfat diets are especially at risk. Fish are a good dietary source, but must be eaten several times a week to provide enough DHA for optimal brain function. Fish obtain their DHA from microalgae – the nutritional basis of NEUROMINS.

    Neuromins: a Pure, Safe Source Source Naturals DHA is obtained from NEUROMINS, a dietary supplement derived from algae in a base of sunflower oil. NEUROMINS DHA is a highly purified form of DHA, produced under tightly controlled manufacturing conditions. Unlike fish oil, which used to be the main supplemental source of DHA, NEUROMINS does not contain the fatty acid eicosapentaenoic acid (EPA), which is not recommended for infants or children. Source Naturals NEUROMINS DHA is available in bottles of 30, 60 and 120 softgels, in both 100 and 200 mg dosages. Pure, safe DHA in the 200 mg dosage may be especially beneficial for pregnant or nursing women.

    References
    Crawford, M.A. (1990). Upsala J Med Sci Suppl 48: 43-78.
    Crawford, M.A. et al. (1993). Nutr and Health: 9. 81-97.
    FAO/WHO Expert Committee (1994). Fats and Oils in Human Nutrition.
    Food and Nutrition Paper No. 57. FAO: Rome. 49-55.
    Hibbeln, Joseph R. & Salem, Norman Jr. Am J Clin Nutr: 62. 1-9.
    Horrobin, David F., ed. (1982). Clinical Uses of Essential Fatty Acids. Eden Press. 3-36.
    Makrides, M. et al. (1996). Eur J Clin Nutr:50. 352-7.
    Sanders, T.A.B. & Reddy, Sheela (1992). J Pediatr: 120. S71-7.
    Simopoulos, Artemis P. (1989). J Nutri 119: 521-8.
    Simopoulos, Artemis P. (1991). Am J Clin Nutr: 54. 438-63.
    Söderberg, M. et al. (1991). Lipids 26: 6. 421-5.
    Uauy, Ricardo et al. (1992). J Pediatr: 120. S168-80.



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    Attentive Child - Enhances Mental Concentration ...
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    Date: May 31, 2005 05:14 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Attentive Child - Enhances Mental Concentration ...

    Most children are creative, energetic and spontaneous, but sometimes they don’t focus on requested activities. Sometimes kids find it difficult to apply themselves to the task at hand. Your child’s brain also may work differently than most people’s brains— just like the 5% of the population that is left-handed. Most people think an ultra-active child means an active brain, but active children may actually need a boost in brain metabolism. Source Naturals ATTENTIVE CHILD is a Bio-Aligned Formula™ designed to address the multiple systems that affect children’s ability to focus: neurotransmitters and brain metabolism, nerve cell communication, antioxidant defense, and essential fatty acid metabolism.

  • Formerly FOCUS CHILD™
  • Comprehensive Brain Support

    Parents are looking for a safe and natural product to support their children’s ability to focus. Source Naturals studied the research and created an experiential formula, based on the latest breakthroughs in Cerebral and nervous system biochemistry. Each ingredient in ATTENTIVE CHILD plays a role in brain and nervous system structure or functioning, or is involved in important biochemical pathways. DMAE, a substance normally found in the brain, boosts brain metabolism and has been shown to enhance concentration. L-Aspartate is an amino acid neurotransmitter that stimulates brain activity. Research has shown that some ultra-active children may have special dietary needs for magnesium, zinc and DHA (docosahexaenoic acid). Magnesium is necessary for the transmission of nerve signals, and, along with zinc, for the processing of essential fatty acids into other vital biochemicals. DHA is an essential fatty acid that is very important for Cerebral development and effective communication between nerve cells in the brain. Lecithin contains four phospholipids—fatty acid building-block molecules in nerve cell membranes. Phosphatidylserine, in particular, is vital in nerve cell communication and the electrical activity of the brain. Grape seed extract is a plant-derived antioxidant that protects the integrity of fatty acids in nerve cell membranes.

    ATTENTIVE DHA™ in Tiny Kid Caps™

    The ATTENTIVE CHILD formula can be supplemented with additional DHA. ATTENTIVE DHA Kid Caps are available in easy-to-swallow, small oval softgels, each containing 100 mg of DHA. For children who can’t swallow caps, simply pierce the gel and mix the oil with food. Sweeteners with Low Impact on Blood Sugar The delicious sweetand- tart taste in ATTENTIVE CHILD wafers comes from natural flavors, specially manufactured without sugar for Source Naturals. Unless specified, most flavors in other products contain maltodextrin, a sugar with a high glycemic index. The ATTENTIVE CHILD wafer itself is sweetened with crystalline fructose (natural fruit sugar) and xylitol (a naturally occurring sweetening agent found in many fruits and vegetables). These select natural sweeteners have a very low glycemic index—so ATTENTIVE CHILD will taste great to your child, but have little effect on blood sugar levels. We recommend carefully reviewing the labels of other products. They may contain honey, glucose, sucrose, maltodextrin, and maltose—all of which have moderate-tohigh glycemic indexes. In addition, maple sugar, molasses, malt syrup, rice syrup, and beet sugar contain varying amounts of high-glycemic-index sugars, which can set off blood sugar fluctuations that may affect concentration. Beware of children’s nutritional bars designed to enhance focus and concentration. Most have over 20 grams of sugar per bar. In contrast, each serving of ATTENTIVE CHILD contains only two grams of crystalline fructose, which has little effect on blood sugar.

    Glycemic Index of Various Sweeteners

    The glycemic index is a ranking of foods based on their immediate effect on blood glucose levels. It measures how much your blood glucose increases over a period of two or three hours after intake. The higher the glycemic index (GI), the greater the fluctuations in blood sugar. Sweetener Glycemic Index†
    Xylitol* 7.0
    Crystalline Fructose* 23.0
    Organic Agave Nectar†† 10.0
    High Fructose Corn Syrup 62.3
    Sucrose 65.0
    Honey 73.0
    Glucose 97.0
    Maltodextrin 105.0
    Maltose 105.0

    *sweeteners used in ATTENTIVE CHILD ™ †based on rate of 100 for glucose ††for information, see website www.wcommerce.com

    Lifestyle Strategies for Your Child

    You can help your child concentrate on schoolwork, chores and other challenges. Start with ATTENTIVE CHILD and ATTENTIVE DHA, and then incorporate a healthy lifestyle and nutrition routine.

    Physical Health

    Have your child’s overall health checked by a welltrained holistic health care professional, such as a naturopathic physician. It is particularly important to examine the functioning of your child’s thyroid gland (the master regulator of the body’s metabolism, which influences mood and energy level), and blood sugar metabolism (the brain depends on a steady supply of glucose to function properly, particularly when you are trying to concentrate).

    Nutritional Health: Feeding the Brain

    Help your child maintain a steady supply of energy and brain fuel by providing a balanced diet. Small, frequent meals are preferable since they dispense a steady level of glucose to the brain. Include foods high in the amino acid tyrosine, a precursor to neurotransmitters that support an alert state. It is found in protein foods, such as meat, poultry, beans, tofu, lentils and seafood. Also include complex carbohydrates such as whole grains, fruits and vegetables, which are metabolized slowly and yield a steady supply of glucose. The simple sugars found in candy, cookies, sodas and other processed foods can lead to a rapid rise in blood sugar levels, followed by an abrupt decline, and should be discouraged. It is important to include essential fatty acids, especially omega-3 fatty acids, which are abundant in the brain and essential for its development and normal functioning. Supplement with ATTENTIVE DHA, and encourage your child to eat cold-water fish, such as salmon. Avoid the hydrogenated fats found in processed foods and margarine, as well as chemicals and food additives. A nutrition program consisting of fresh, unprocessed natural foods is the healthiest choice for everyone.

    Lifestyle Health

    Some experts believe extended time watching TV and playing video games does not support optimal health or school performance. EEG studies have shown that these activities decrease brain activity rather than activating the brain. Encourage your child to spend time in outdoor physical recreation and in creative, challenging activities.

    Supplement with ATTENTIVE CHILD and ATTENTIVE DHA

    ATTENTIVE CHILD is available in bottles of 30 & 60 chewable wafers. ATTENTIVE DHA Kid Caps (algal-source Neuromins®) are available in 30- & 60-softgel bottles. References Amen, D. Windows into the....Mind. Fairfield, CA: MindWorks Press, 1997. Foster-Powell, K. & Miller, J.B. 1995, International tables of glycemic index. Am J Clin Nutr. 62:871S-93S. Natah, S.S. et al. 1997. Metabolic response to lactitol and xylitol in healthy men. Am J Clin Nutr. Apr; 65(4):947-50. Schmidt, Michael. Smart Fats. Berkeley: Frog, Ltd., 1997. Sears, William. Boston: Little, Brown & Co., 1998.



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    Arcticpure EFA and EPA Fish Oil supplement ...
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    Date: May 31, 2005 05:05 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Arcticpure EFA and EPA Fish Oil supplement ...

    Essential fatty acids are crucial for health—as much so as daily vitamins and minerals. And fish oil is one of the best sources of these nutrients. Now Source Naturals offers you three premium fish oil concentrates. ARCTICPURE DHA supplies the essential brain nutrient DHA. ARCTICPURE EPA is ideal for cardiovascular support and joint mobility. ARCTICPURE EFA contains a blend of healthful fatty acids. All ARCTICPURE products contain fish oils from the cleanest and coldest body of water, the Arctic Sea. A series of distillation processes concentrates and extracts beneficial fatty acids, while guaranteeing the absence of heavy metals and PCB’s.

    EFA’s: Healthy Fats

    Essential fatty acids (EFA’s) support an amazing variety of cellular processes. They maintain cell wall and membrane integrity, generate energy, produce hormones and support brain, nerve, and eye function. Yet too many people today eat diets that are high in saturated or hydrogenated fats, but low in healthy fats—essential fatty acids. ARCTICPURE softgels are an excellent source of EFA’s, including docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), gamma linolenic acid (GLA), and alpha linolenic acid (ALA). ArcticPure DHA™ DHA is an omega-3 long chain fatty acid that is the primary building block of the brain and retina of the eye. The brain is 60% fat, and DHA is the most abundant fatty acid in the brain, comprising 25-35%. DHA is found in even greater concentrations—50-60%—in the retina. DHA is critical for infant development, especially the rapid Cerebral and eye development that occurs during pregnancy and in the first few months after birth. It is therefore an important nutrient for pregnant women and nursing mothers. DHA also has been associated with optimal memory function, visual acuity, and maintaining a positive mental state. It is an integral component of all membranes with electrical activity, including the cells in our brain and nervous system. ARCTICPURE DHA contains 50% DHA, or 250 mg, in each softgel.

    ARCTICPURE EPA™

    EPA is another omega-3 fatty acid, which has been associated with many potential health benefits. Epidemiological and animal studies have shown that EPA can support a healthy cardiovascular system. It is important for healthy skin and is a precursor of prostaglandins, thromboxanes and leukotrienes. These chemical mediators help regulate a variety of physiological processes, including blood pressure and blood clotting. ARCTICPURE EPA supplies 45% (450 mg) of EPA—one of the highest concentrations available.

    ARCTICPURE EFA™

    ARCTICPURE EFA is a source of EPA, DHA, and also GLA (gamma-linolenic acid) from borage oil, and additional omega-3 fatty acids including ALA. GLA is an essential polyunsaturated fatty acid. It is used by most cells to produce the soothing, intracellular, hormonelike messengers known as series 1 prostaglandins (PGE1), which help maintain the balance of many functions in the body. GLA supports the immune system and helps maintain healthy skin and circulation. This essential nutrient is incorporated into our cell membranes, where it helps to maintain fluidity and permeability.

    Stabilized for Freshness

    ARCTICPURE oils are enhanced with antioxidants such as lecithin, ascorbyl palmitate, vitamin E and rosemary oil, for extended shelf life. They also contain natural fruit flavors, so there is no fishy taste! ARCTICPURE softgels are pleasing to both children and adults.



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