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EpiCore Benefits   
Date:
April 09, 2007 05:02 PM
EpiCor® is a unique and novel dietary supplement used for support of immune health, with a fascinating history of discovery. In 1943, a company in
Interestingly, when the company became self-insured, they became aware of unusually low rates of illness in employees that worked in the manufacturing plant for this animal product. This led to very low increases in their insurance premiums over the years compared to other companies, saving them quite a lot of money. Hence they began to investigate what might be the cause of the “healthfulness” of the employees at the fermentation plant. This investigation and subsequent research studies led to the formation of a new company called Embria Health Sciences, which now produces EpiCor® as a supplement for humans to support immune system health.1 Doctor’s Best® is proud to now offer the benefits of EpiCor® to its customers.
Beneficial Support of the Immune System and Activation of Natural Killer (NK) Cells in vitro*
A comparison study was performed on blood from 10 fermentation plant workers compared to that from 10 age and gender matched controls. The fermentation plant workers had several immune cell parameters that appeared superior to the control group. These included decreased levels of CD8 cells resulting in significantly increased CD4 to CD8 ratios, significantly improved cytotoxic natural killer (NK) cell activity even though total NK cells were decreased in number, higher killing efficiency of NK cells, significantly increased levels of secretory IgA, increased numbers of EpiCor™ specific antibodies, higher levels of red blood cell intracellular glutathione, and significantly lower levels of immune complexes. These results represent benefits on various cellular players of both the specific and innate parts of the immune system.1,3,4
NK cells are one of the first lines of defense used by the immune system. An in vitro study performed on human cells showed that NK cells were activated after incubation with EpiCor®, as evaluated by expression of the CD69 activation marker. The CD25 marker (IL-2 receptor) was also induced in the NK cells, although to a lesser degree.1,2 B cell activation was also noted through increased expression of CD80 and CD86 markers.2 Immediate increases in calcium levels were evident in peripheral blood mononuclear cells after exposure to EpiCor®, suggesting increased activation through calcium regulation.2
High Metabolite Immunogen*: Nutrient Make-up
Production of EpiCor® utilizes the common and harmless bakers or brewers yeast Saccharomyces cerevisiae in a patented process called MetaGen4™, a multi-stage fermentation and drying process. It differs from other yeast products in that it contains both the yeast itself as well as the metabolites or “nutrilites” formed by the fermentation process, which are present in the media.1 Together the media containing the metabolites and the yeast are dried to form EpiCor®. Analysis of EpiCor® reveals that it contains a mixture of natural polyphenols, phytosterols, beta-glucans, mannan oligosaccharides, fiber, trace amounts of B vitamins and minerals, as well as a host of other nutritional compounds.1,2
Beneficial Antioxidant Activity*
EpiCor® was tested for antioxidant activity in an in vitro assay called the Oxygen Radical Absorbance Capacity assay (ORAC). In this assay, EpiCor® was shown to have a total ORAC antioxidant level of 610 micromol TE (tocopherol (vitamin E) equivalents) units (ORAC units) per gram dry weight, which soared above other high antioxidant level foods such as cranberries (93 ORAC units per gram dry weight) and blueberries (62 ORAC units per gram dry weight).1,3,5
In another study, freshly isolated human neutrophils were treated with EpiCor® followed by the free radical generator hydrogen peroxide. Cells were treated with a dye that fluoresces when attacked by free radicals. Those cells treated with EpiCor® showed decreased fluorescence intensity compared to control cells not treated with EpiCor®, verifying antioxidant activity in vitro.2
Safety
Numerous safety tests have been conducted on EpiCor®, revealing an extremely safe profile. Animal studies performed by a leading toxicology laboratory showed no indication of any toxic effects of EpiCor®. An acute oral toxicity study on 20 rats showed that the product was safe when given to rats at a single oral dose of 2000 milligrams per kilogram of body weight (equivalent to a human ingesting 280 capsules at once). After 2 weeks the rats showed no clinical symptoms, no deaths, no abnormalities in body weight, and no gross pathological changes. The same safety results were found in a subchronic toxicity study where rats were given up to 1500 milligrams daily for 90 days (equivalent to a human ingesting up to 210 capsules daily for 1.5 years). Again, absolutely no signs or symptoms of toxicity were noted in these animals.1,3
In addition, a standard bacterial reverse mutagenicity test (AMES test) as well as a mammalian cell mutation assay using mouse lymphoma cells revealed no evidence of any increase in mutation rates after exposure to EpiCor®. EpiCor® also showed no evidence of mitogenicity (inducing increased cell division) in a human lymphocyte proliferation assay. This suggests that EpiCor® does not cause over-reactivity of cells1,3.
The effect of EpiCor® on specific liver enzymes CYP1A2 and CYP3A4 (enzymes involved in metabolizing certain drugs and other compounds) was assessed. Immortalized hepatocytes (liver cells) were treated with various concentrations of EpiCor® and compared to both positive and negative controls. EpiCor® did not increase the expression or activity of the liver enzymes, suggesting that it may not affect the metabolism of other substances or medications metabolized by these enzymes if they are taken simultaneously. It also did not appear to be toxic to the cells as measured by lactate dehydrogenase assays and microscopic analysis.1
Lastly, EpiCor® was tested for safety in humans in an open label study on 15 adult men and women given a single 500 milligram dose for 30 days. On various days throughout the study vital signs were monitored, and blood and urine samples were analyzed. No clinically relevant abnormal effects on the participants were found1.
EpiCor® also currently has received self-affirmed Generally Regarded as Safe (GRAS) status by an expert panel that included eminent toxicologists1.
EpiCor® is a novel compound with an incredibly unique composition that has been shown to enhance immune system function.*
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Scientific References
1. Embria Health Sciences
2. Hart et al. A new Saccharomyces cerevisiae based product has anti-inflammatory effects while specifically activating human NK and B lymphocyte subsets. Unpublished study, personal communication.
3. Schauss AG, Jensen G, Vojdani A, Financsek I. After decades of ingestion by farm animals, the discovery of a yeast fermentate with unexpected significant immune modulatory activity when consumed by humans. [abstract] Journal of the
4. Schauss AG, Vodjani A. Discovery of an edible fermentation product with unusual immune enhancing properties in humans. [abstract] FASEB J, 2006; 20(4):A143.
5. Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1508) TEA TREE OIL (Meleleuca alternifolia)  
Date:
July 11, 2005 09:32 PM
TEA TREE OIL (Meleleuca alternifolia) Another important component of the first aid kit is tea tree oil. It can help with many minor conditions that commonly occur. Some include athlete’s foot, acne, boils, burns, warts, vaginal infections, tonsillitis, sinus infections, ringworm, skin rashes, impetigo, herpes, corns, head lice, cold sores, canker sores, insect bites, insect repellent and fungal infections. It is truly a remarkable oil with valuable properties for healing and to prevent infection. Tea tree oil is extracted from the leaves of Melaleuca alternifolia which is a shrub like tree found in the northeast t ropical coastal region of New South Wales and Queensland, Australia. There are over 300 different varieties of tea tree but only a few are known to produce the valuable, medicinal oil. Tea tree oil contains at least 48 different organic compounds. The compounds work together to produce the healing abilities found in the oil. Research done in the 1950s and early 1960s found that tea tree oil is a germicide and fungicide with additional characteristics of dissolving pus and debris.1 Recent studies have found it effective for thrush, vaginal infections of candida albicans, staph infections, athlete’s foot, hair and scalp problems, mouth sores, muscle and joint pain, pain, and boils.2 Tea tree oil is a valuable antiseptic for skin infections. It is able to penetrate the epidermis to heal from within. Clinical studies have found that tea tree oil can heal quickly and with less scarring than other treatments. The oil is even effective against Staphylococcus aureus, which is often difficult to treat and is becoming resistant to antibiotic therapy. The oil can be applied two to three times a day with full strength or diluted. If an irritation occurs, a diluted solution can be tried. Even highly diluted concentrations have been found to heal in clinical studies. Organisms against which tea tree oil has been shown to be effective include aspergillus, baceroides, Candida, clostridium, cryptosporidium, diptheroids, E. Coli, enter-obacter, epidermophyton, fusobacterium, gonococcus, hemophilus, herpes viruses, meningococcus. microsporium, petococcus, proteus, pseudomonas, spirochetes, staph, strep, trichinosis, and trichophyton3 Tea tree oil is an effective bactericide. It is safe for healthy tissue. It is a strong organic solvent and will help heal and disperse pus in pimples and wounds. It has been used to neutralize the venom of minor insect bites. It is able to kill bacteria by penetrating the skin layers and reaching deep into abscesses in the gums and even beneath the fingernails. It has been found to have some of the strongest antimicrobial properties ever discovered in a plant.4 Tea tree oil can help with fungal infections such as candida. Dr. Eduardo F. Pena, M.D. has studied Melaleuca alternifolia oil for its value in treating vaginitis and candida albicans.5 In studying candida researchers have gone to the extreme of infecting healthy volunteers with the organism. The yeasts proceeded to invade the bloodstream and internal organs. Then they were cultured from these regions. However, within a matter of hours yeasts could no longer be cultured, indicating that the immune systems of these individuals efficiently cleared the organisms from the tissues. Unfortunately, in today’s era a great many people are afflicted with compromised immune function.6 Tea tree oil acts as a mild anesthetic when applied to painful areas and to soothe cuts, burns, and mouth sores. It can help heal as well as reduce scarring. Burn victims in Australia are often treated with tea tree oil to help prevent infection, relieve pain and speed healing. Tea tree oil can help prevent and heal acne. Tea tree oil has a reputation of being gentle on the skin. It does not produce the side effects of some medications such as dry skin, stinging, burning and slight redness after application. Tea tree oil can help to heal and prevent infections from occurring. A minor scrape or scratch can sometimes result in infection. Tea tree oil applied to the area can help prevent infection. The oil is effective in healing many types of bacteria but the most amazing thing is that is does not damage the skin tissue. Many of the recommended treatments can actually do damage to the skin resulting in scarring and sensitivity. Tea tree oil can be used to prevent bites and stings. Bugs don’t like the scent and may stay away. There is no way to entirely void coming into contact with insects. Anyone who likes to be outdoors is vulnerable. Whether you live in the city or the country or anywhere in between, bugs abound. Tea tree oil or lotions and creams containing the oil can also be used to prevent bites. Insects don’t like the scent of the oil and are actually repelled by it. The Australian tea tree oil has been found to be highly effective in treating infections and destroying microbes while not irritating the skin. Many antiseptics can cause skin irritation, but tea tree oil seems to cause no harm to skin tissue. Tea tree oil is an antiseptic and generally not taken internally. Some evidence has suggested mild organ damage from internal use. The oil when absorbed through the skin is non-toxic. Tea tree oil is most often recommended for exposed surfaces of the body such as the skin tissue and the mucous membranes. It should be noted that the original Australian aborigines made tea from the leaves without adverse affects. And the early settlers followed their exam - ple with positive results. But the tea was a very diluted form and the distilled oil is much stronger.
Endnotes
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