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  Messages 1-12 from 12 matching the search criteria.
Is this cruciferous vegetable the key to brain regeneration? Darrell Miller 4/24/19
Ribose Energy-Boosting Heart Supporter or Sugar Trap? Darrell Miller 1/9/19
Early signs of liver damage that everyone should know Darrell Miller 12/8/16
The Liver Is A Very Imprtant Organ Darrell Miller 9/30/16
If You Are Having Trouble With Night Driving, Bilberry Extract Could Help Darrell Miller 2/2/11
Glucosamine Sulfate Darrell Miller 10/2/08
Benefits of Best Alpha Lipoic 35! Darrell Miller 2/12/06
Dr. Verghese, M.D. Liver Detoxifier & Regenerator Fact Sheet Darrell Miller 12/7/05
Benefits of Alpha Lipoic Acid Darrell Miller 10/13/05
Gotta Habit Darrell Miller 6/14/05
Energy Cycles - Stress and lack of energy don't just frazzle your nerves Darrell Miller 6/12/05
Multiple - Why take them? Darrell Miller 6/9/05




Is this cruciferous vegetable the key to brain regeneration?
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Date: April 24, 2019 03:12 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Is this cruciferous vegetable the key to brain regeneration?





Scientists have been researching ways of achieving brain regeneration for decades, but the article suggests that cruciferous vegetables is a method of regenerating the brain. An MIT scientist discovered that the growth of nervous tissue is aided by phyto-substances, which is a nutrient that can be found in common vegetables, like broccoli. A compound found in broccoli also has more positive effects on the body, as it has anti-inflammatory properties. Broccoli is helpful for elderly patients that suffer from degenerative diseases.

Key Takeaways:

  • Toxins that are present in the air, water, and food can significantly interfere with one’s ability to learn, remember, and even communicate.
  • It was formerly believed in the past by scientists and considered a settled issue that brain regeneration was not a possibility.
  • Today, it is being observed by scientists that brain regeneration by cruciferous vegetables is possible. Joseph Altman, an MIT scientist, was the first to make this observation in 1960.

"This natural process of brain regeneration is expedited by certain beneficial phyto-nutrients, and hampered by certain toxic elements."

Read more: https://www.naturalnews.com/2019-03-09-is-this-cruciferous-vegetable-the-key-to-brain-regeneration.html

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Ribose Energy-Boosting Heart Supporter or Sugar Trap?
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Date: January 09, 2019 09:15 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Ribose Energy-Boosting Heart Supporter or Sugar Trap?





Ribose is a natural energy-boosting chemical that our bodies produce in order to provide our cells with the appropriate energy levels. It has been shown to support heart health by regenerating the necessary energy levels that can be depleted by cardiovascular disease. Ribose has also shown to help patients who are suffering from left ventricular diastolic dysfunction. Other advantages of ribose include: improved skin health, better workouts due to the energy increase, and aiding in the treatment of fibromyalgia.

Key Takeaways:

  • Ribose is also known as D-ribose. It is naturally created by our bodies and provides sufficient energy to the body cells.
  • The sources for D-ribose include plant and animal sources. Sometimes, it can also be obtained as a supplement.
  • D-ribose is unlike every other sugar which can increase blood sugar. People are warned that D-ribose can even lower blood sugar.

"In fact, scientific studies show that D-ribose may help a number of serious health concerns, including heart diseases, fibromyalgia symptoms and chronic fatigue syndrome."

Read more: https://draxe.com/ribose/

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Early signs of liver damage that everyone should know
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Date: December 08, 2016 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Early signs of liver damage that everyone should know





Our livers clean our blood of impurities and toxins, while asisting our bodies with fighting off infections. The liver has the ability to repar itself by regenerating damaged tissues. But when the liver suffers irrepairable damage like cancer, inflammation or scarring, our bodies react by producing outwardly signs. First, your stools will lighten and your urine will become more yellow, as well as your skin and eyes. Also, you may begin to feel itchy and you may bruise or bleed more easily. Additionally, your body will retain excess water, causing your body to swell.

Key Takeaways:

  • When your liver isn't working properly, your skin and the whites of your eyes can become discolored, turning a milky yellow due to the accumulation of a yellowish substance called bilirubin.
  • One of the signs of early liver damage is systemic itching. Your itching may be limited to a certain region, such as your arms or legs, or it may be occurring all over your body.
  • Folks with damaged livers will tend to bruise and/or bleed much more easily because the organ has slowed or ceased production of proteins that are vital to blood clotting.

"Despite the fact that the liver is inside the body, a poorly-functioning organ produces some outwardly visible signs that should always be heeded."



Reference:

//www.naturalnews.com/056148_liver_disease_yellow_skin_symptoms.html

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The Liver Is A Very Imprtant Organ
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Date: September 30, 2016 02:00 PM
Author: Darrell Miller
Subject: The Liver Is A Very Imprtant Organ

Positioning at the right side of the belly, The Liver, is the most significant internal organ of our body. Along with intestine and pancreas, it perform the function of digesting, absorbing and processing the food.

The most important function of the liver is to purify the blood before advancing it to the rest of the body. It also removes harmful toxic gases from the blood and helps in production of hormones. In other words, Liver is " Blood Purifier" of our body !

Liver Diseases

But various diseases like the Hepatitis, Cirrhosis, Liver cancer, Ascites , Gallstones can reduce the smooth functioning of the liver. This is why we need an aid to the liver, "Milk Thistle",a flowering herb is used as a natural treatment.

It is one of the strongest detoxifiers which helps in regenerating the liver cells, and it reduces the harmful effects of alcohol consumption, presence of heavy metals in our water supply and pesticides in our food. It can even back-pedal the effect of pollution in the air we breathe!

Milk thistle has been recognized as a therapeutic treatment for above mentioned liver diseases. It can also be used for lowering the cholesterol level, or as an anti-aging treatment.

If you are experiencing liver function issues,  consider taking milk thistle daily.

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If You Are Having Trouble With Night Driving, Bilberry Extract Could Help
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Date: February 02, 2011 10:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: If You Are Having Trouble With Night Driving, Bilberry Extract Could Help

Night blindness is very common nowadays. According to statistics, a lack of vitamin A is the primary cause of night blindness or inability to see at night or in dim light. The treatment of this eye condition will depend upon the cause. Treatment may be as simple as getting a new eye glasses prescription. But invasive procedures may also be required most especially those that are caused by cataracts. Fortunately, Bilberry extracts may help night blindness. bilberryleafplant

Bilberry is a low – growing perrenial shrub growing approximately 15 to 20 inches in height. It is a member of the family Ericaceae in the genus Vaccinium. Its branches are green with sharp edges. It bears edible berr that is seemingly wrinkled and black. Bilberry is a comparative to the common berries known as blueberry and cranberry. The active compounds in bilberry fruit are known as anthocyanosides. Bilberry extract has a deep bluish purple tone which contains the majority of the active substance of the fruit known as anthocyanidin. Anthocyanidin is a component of anthocyanosides. It can help increase the formation of rhodopsin. According to studies, rhodopsin is formed from an aldehyde form of vitamin A called retinaldehyde, or retinal as commonly used. It is then bound to the protein opsin. This compound consisting of retinal and opsin is stored in photoreceptors of the retina of the eye known as rods and cones. Rhodopsin is the compound in the eye that is responsible for adjusting eye perception to light variations.

This plant extract is also commonly used for treating eye problems like cataracts and retinal disorders particularly retinopathy. Scientists found out that anthocyanosides help protect the retina. Since bilberry improves the formation of rhodopsin, adequate levels of rhodopsin can significantly improve night vision and reduce visual fatigue. This eye pigment could help those individuals who are having trouble driving at night because of its rhodopsin regenerating property.

Aside from supporting a healthy eye function, bilberry has many other health benefits. It has an antioxidant, anti – inflammatory, collagen stabilizing and vasoprotective properties. Generally, anthocyanosides are considerably beneficial to the overall health of the body. It can improve circulation by preventing blood clumping by reducing platelet aggregation. It can also prevent or reduce the amount and extent of damage to cells caused by free radicals.

Further clinical studies are being done to be able to get concrete evidence on the fruit’s benefits especially to the eyes. Preliminary results show that bilberry decreases eyestrain after an excessive use of computers, protects against glaucoma by improving blood vessel integrity in the eyes, reduces the occurrence of cataracts by maintaining the integrity of connective tissues in the eyes and lessens the risk of retinopathy among diabetic patients. Preparations of bilberry extracts include teas, capsules or tablets.

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Glucosamine Sulfate
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Date: October 02, 2008 09:36 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Glucosamine Sulfate


It is possible to rebuild joint cartilage with glucosamine sulfate, although how quickly that occurs could depend upon what you take with it. First, though, an understanding of exactly why cartilage deteriorates will be useful in your understanding of how glucosamine sulfate can help towards repairing the damage.

Cartilage has several roles to play in your body, an example of which is to form curved body parts that would otherwise be unsupported, such as the external contours of your ears or a large part of your nose. Without cartilage you ears and nose would flop around a lot, and it is also contained in the spine, to prevent your discs from grinding against each other.

However, the part that we are interested in is as a shock absorber between the bones of your joints. It allows bones to slide over one another without damage, either through friction or shock, and is also nature’s shock absorber, helping to support your weight while you are active. Thus, your cartilage protects from impact damage when you are running or jumping down from a height. This type of cartilage, known as articular cartilage, is bathed in a lubricating fluid known as synovial fluid, which introduces its own problems when your cartilage becomes damaged.

This damage can occur in several ways: as the result of a fall, for example, or direct contact with the joint when playing a physical contact sport such as football or soccer. It can also become damaged through wear and tear over a period of time, such with long distance runners or soccer players (again), and is also associated with age. Many years of continual use, especially amongst those with active rather than sedentary occupations, eventually lead to wear and damage.

Problems with the joint structure itself, known as osteoarthritis, can also damage the cartilage, as can being overweight for a lengthy period. You can also experience cartilage damage if you are bedridden or other wise immobile for long periods, because the cartilage needs regular movement to function correctly. This is connected with the blood supply, which will be discussed shortly.

Cartilage is constructed of cells known as chondrocytes that generate a fibrous matrix known as collagen, a mixture of amino acids known as elastin that allows the cartilage to return to its original shape after deformation, and non-collagenous matrix tissue containing proteins, water and proteoglycans that contain sulfated glycosaminoglycan chains. That last mixture is often referred to as ‘ground substance.’

One of the problems with cartilage is its lack of a direct blood supply, and it relies on the compression and decompression of the articular cartilage, or on the flexing of elastic cartilage, to create a pumping action that drives blood to the chondrocytes. This is why inactivity can cause cartilage damage, due to a lack of blood supply, and why it is repaired more slowly than other body components.

Once an injury or wear and tear damages a joint, the body’s natural defense, the immune system, is activated, and the major part of that involved in cartilage damage is the inflammatory response. The joint becomes inflamed, the quantity of synovial fluid is increased to provide more protection and swells the joint, and enzymes (hyaluronidase) are produced which, although part of the natural defense system, actually degrade the synovial fluid and the cartilage.

This increases the amount of inflammation and the process becomes self-perpetuating, leading to the condition known as degenerative joint disease (DJD) because the body is unable to produce enough glucosamine to generate the proteoglycan needed for repair.

This is where glucosamine sulfate enters the scene. Glucosamine is a precursor for glycosaminoglycans (GAG), which as mentioned as above are components of proteoglycans in the cartilage matrix ground tissue. It has been shown to stimulate the biosynthesis of proteoglycan, and analysis has shown its presence within articular cartilage after administering it orally to patients with cartilage disease. It therefore makes its way to the right place.

Glucosamine is administered in the form of glucosamine sulfate, the highly electrically charged sulfate groups believed to aid in the compression properties of cartilage. It is rapidly absorbed into the bloodstream, although only about a quarter of the oral dose is eventually available to the body, and high concentrations accumulate in the liver, kidneys and in articular cartilage where it is used in the biosynthesis of GAG.

When in solution, glucosamine sulfate separates into ions: sulfate and glucosamine. Glucosamine ions are involved in the synthesis of GAG, that then combine with proteins to form proteoglycans, a component of the non-collagenous matrix of the cartilage. Although glucosamine is the major active component, there is evidence that the sulfate group contributes the stability of the matrix of the connective tissue since the uptake of sulfate ions increases with the amount of glucosamine sulfate used.

Another consideration here is that sulfate is an important part of proteoglycans, and glucosamine sulfate promotes not only the synthesis of glycosaminoglycans, but also of proteoglycans in general. Glucosamine is also active in regenerating the lubricating properties of the synovial fluid, and in hindering the activity of hyaluronidase, the enzyme that breaks down the hyaluronic acid in the synovial fluid.

Some people find that glucosamine, taken either alone or in conjunction with chondroitin sulfate and/or methyl sulfonyl methane (MSM), is more effective than the non-steroidal anti-inflammatory drugs (NSAIDs) used to reduce inflammation (e.g. Aspirin and Ibuprofen) and without the side effects of these substances. MSM contains dietary sulfur, which is necessary for cell structure and healthy cell repair. Methyl sulfone methane is know to be beneficial for painful conditions such as arthritis, and also improves the blood circulation. It might also play a part in helping glucosamine sulfate get to the site of the cartilage damage.

Glucosamine is a large molecule, however, and finds it difficult to make its way to the area around the joint due to the lack of a direct blood supply. It is therefore taken in relatively large doses to ensure that sufficient amounts get to where it is needed. Many people insist that glucosamine sulfate is very effective in reducing, or even eliminating, their pain, and it is finding increasing popularity in the treatment of arthritis and other conditions involving cartilage damage.

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Benefits of Best Alpha Lipoic 35!
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Date: February 12, 2006 03:11 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Best Alpha Lipoic 35!

Benefits

Supports the Body’s Defense Against Free Radicals*

Recycles Antioxidant Nutrients such as Vitamin C and Vitamin E*
Helps Maintain a Healthy Blood Sugar Level when used as part of the diet*

Alpha-lipoic Acid––the "Ideal Antioxidant"
The antioxidant potential of a substance is based on a number of criteria, including:
1) Ability to quench specific free-radicals.
2) Ability to bind or "chelate" metal ions that can generate free radicals.
3) Supports function of other antioxidants.
4) Absorption/bioavailability.
5) Concentration in tissues, cells and extra cellular fluids.
6) Ability to function as an antioxidant in fatty and watery environments.


The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes.

As a team, ALA and DHLA come close to the ideal, for the following reasons:1,2,3
1) ALA is easily absorbed when consumed orally.
2) ALA is readily converted to DHLA in various tissues.
3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals.
4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions.
5) ALA and DHLA scavenge free radicals in fatty environments and watery environments.
6) DHLA recycles other important antioxidants.


DHLA-regenerates vitamin C, vitamin E and glutathione

Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants.

DHLA is an essential component in the interaction between these antioxidants.4 Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form.3,5 The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells.4 DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes.6 Evidence from animal studies suggests that DHLA protects the brain against free radical damage.7

Alpha-lipoic Acid and Blood Sugar

Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA.8 In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved.9 In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells.10



Safety

Suggested Adult Use: One to six capsules daily with food.

Alpha-lipoic acid is considered safe, and no adverse effects have been seen with long-term supplementation.1

Scientific References
1. Packer, L.. Witt, E., Tritschler, H. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995;19(2):227-50.
2. Suzuki, Y., et al. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Comms. 15(5):255-63.
3. Biewenga, G., Haenen, G., Bast, A. The pharmacology of lipoic acid. Gen. Pharmac. 29(3):315-31.
4. Serbinova, E. Maitra, I., Packer, L. The synergy between vitamin E and alpha-lipoic acid--–possible relationship against oxidative stress in vivo. Life Chemistry Reports 1994;12:17-21.
5. Bast, A. Haenen, G. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochimica et Biophysica Acta 1988; 963:558-561.
6. Kagan, V. et al. Dihydrolipoic acid––a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992;44(8):1637.
7. Prehn, J. et al. Dihydrolipoate reduces neuronal injury after cerebral ischemia. J Cereb Blood Flow Metab 1992;12(1):78-87.
8. Jacob, S. et al. Enhancement of glucose disposal in patients with type-2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45(8):872-4.
9. Jacob, S et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology & Medicine 1999;27(3/4):309-14.
10. Estrada, D. et al. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-804.


--
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Dr. Verghese, M.D. Liver Detoxifier & Regenerator Fact Sheet
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Date: December 07, 2005 12:16 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Dr. Verghese, M.D. Liver Detoxifier & Regenerator Fact Sheet

Dr. Verghese, M.D. Liver Detoxifier & Regenerator Fact Sheet Neil E. Levin, CCN, DANLA 02/10/05

LIKELY USERS: People with exposure to toxins that stimulate liver activity; People with exposure to infections that may have damaged liver tissue

KEY INGREDIENT (S): Milk Thistle extract (Silymarin), Glutathione, NAC, Bupleurum extract, Grape Seed Extract, Dandelion Root extract, Artichoke Leaf, Schisandra and about a dozen additional herbs, along with synergistic ingredients

MAIN PRODUCT FEATURES: This formula was developed by a physician based on his clinical experience.

Artichoke leaf has antioxidant properties and restores healthy growth to liver cells.

Bupleurum may promote normal cell growth, immune function and is a staple of Chinese liver formulas. Dandelion Root may serve as a natural down-regulator of inflammatory chemicals in the body. NAC supports liver Glutathionestores (antioxidant, detoxifier, heavy metal chelator). Schisandra protects liver cells from toxins and may help to regenerate damaged cells. Milk thistle’s antioxidant Silymarin improves liver function tests and protects liver cells against oxidative damage. It also protects liver cells by blocking and removing toxins from the liver. Silymarin aids in regenerating injured liver cells and blocks fibrosis.

OTHER IMPORTANT ISSUES: Samuel Verghese, M.D. (AM), Ph.D., BCIA-EEG, DAAPM, holds a degree in Alternative Medicine and specializes in Nutritional, Ayurvedic and other Alternative Health Solutions. He is certified as a BCIA-EEG Associate Fellow.

AMOUNT TO USE: Three or more capsules a day, preferably with meals.

COMPLEMENTARY PRODUCTS: Antioxidants (supports liver detoxification), Alpha Lipoic Acid, EGCg Green Tea Extract, Astragalus, medicinal mushrooms (shiitake, reishi), SAM-e (may improve bile flow and promotes methylation to detoxify chemicals), TMG, lecithin, thymus glandular extract, Cordyceps.

AVOID: acetaminophen, alcohol, iron supplements (also red meat, fortified flour)

CAUTIONS: This formula should not be used by pregnant women, nursing mothers children or those with liver problems unless recommended under the supervision of a healthcare professional. Please notify your physician about your supplement use if you are using any drugs! Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Salmi HA, Sarna S. Effect of silymarin on chemical, functional and morphological alterations of the liver. A double-blind controlled study. Scand J Gastroenterol 1982;17:517–21.
2. Feher J, Deak G, Muzes G, et al. Liver-protective action of silymarin therapy in chronic alcoholic liver diseases. Orv Hetil 1989;130:2723–7 [in Hungarian].
3. Muzes G, Deak G, Lang I, et al. Effect of silymarin (Legalon) therapy on the antioxidant defense mechanism and lipid peroxidation in alcoholic liver disease (double blind protocol.) Orv Hetil 1990:131:863–6 [in Hungarian].
4. Velussi M, Cernigoi AM, De Monte A, et al. Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients. J Hepatol 1997;26:871–9.
5. Lieber CS. Nutrition in liver disorders. In: Shils ME, Olson JA, Shike M, Ross AC (eds). Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins, 1999, 1179–80.
6. Rodriguez-Moreno F, Gonzalez-Reimers E, Santolaria-Fernandez F, et al. Zinc, copper, manganese, and iron in chronic alcoholic liver disease. Alcohol 1997;14:39–44.
7. Gibbs K, Walshe JM. Studies with radioactive copper (64 Cu and 67 Cu); the incorporation of radioactive copper into caeruloplasmin in Wilson’s disease and in primary biliary cirrhosis. Clin Sci 1971;41:189–202.
8. Lieber CS. Nutrition in liver disorders. In: Shils ME, Olson JA, Shike M, Ross AC (eds). Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins, 1999:1179–80.
9. Halsted CH. Alcohol: medical and nutritional effects. In Ziegler EE, Filer LJ (eds). Present Knowledge in Nutrition, 7th ed. ILSI Press, Washington, DC, 1996, 553.
10. Blum AL, Doelle W, Kortum K, et al. Treatment of acute viral hepatitis with (+)-cyanidanol-3. Lancet 1977;2:1153–5.
11. Suzuki H, Yamamoto S, Hirayama C, et al. Cianidanol therapy for HBs-antigen-positive chronic hepatitis: a multicentre, double-blind study. Liver 1986;6:35–44.
12. Tang W, Eisenbrand G. Chinese Drugs of Plant Origin. Berlin: Springer Verlag, 1992. (Astragalus)
13. Hobbs, C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995, 96–107.
14. Harada T, Kanetaka T, Suzuki H, Suzuki K. Therapeutic effect of LEM (extract of cultured Lentinus edodes mycelia) against HBeAg-positive chronic hepatitis B. Gastroenterol Int 1988;1(suppl 1):abstract 719. 15. Kelly GS. Clinical applications of N-acetylcysteine. Altern Med Rev. Apr1998;3(2):114-27.
16. Montanini S, et al. Use of acetylcysteine as the life-saving antidote in Amanita phalloides (death cap) poisoning. Case report on 11 patients. Arzneimittelforschung. Dec1999;49(12):1044-7.
17. Buckley NA, et al. Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? J Toxicol Clin Toxicol. 1999;37(6):759-67. 18. Girardi G, Elias MM. Effectiveness of N-acetylcysteine in protecting against mercuric chloride-induced nephrotoxicity. Toxicology. Apr1991;67(2):155-64.
19. Berkson MB. Alpha-Lipoic Acid (Thioctic Acid): My Experience With This Outstanding Therapeutic Agent. Journal of Orthomolecular Medicine. 1998;13(1):44-48.
20. Breithaupt-Grogler K, et al. Dose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual data. Eur J Pharm Sci. Apr1999;8(1):57-65.
21. Gebhardt R. Antioxidative and Protective Properties of Extracts from Leaves of the Artichoke (Cynara scolymus L.) Against Hydroperoxide-induced Oxidative Stress in Cultured Rat Hepatocytes. Toxicol Appl Pharmacol. Jun1997;144(2):279-86.
22. Adzet T, et al. Hepatoprotective Activity of Polyphenolic Compounds From Cynara scolymus Against CCl4 Toxicity in Isolated Rat Hepatocytes. J Nat Prod. Jul1987;50(4):612-17.
23. Gebhardt R. Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Toxicol Appl Pharmacol. Jun1997;144(2):279-86.
24. Khadzhai I, et al. Effect of Artichoke Extracts on the Liver. Farmakol Toksikol. Nov1971;34(6):685-87.
25. Newall CA, et al. Herbal Medicine: A Guide for Health-Care Professionals. Cambridge: Pharmaceutical Press; 1996:36-37.
27. Newall CA, et al. Herbal Medicines: A Guide for Health Care Professionals. London: The Pharmaceutical Press;1996:96-97.
28. Bradley PR, ed. British Herbal Compendium. Vol.1. Bournemouth: British Herbal Medicine Association;1992:73-74.
29. Newall CA, et al. Herbal Medicines: A Guide for Health Care Professionals. London: The Pharmaceutical Press;1996:96-97.



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Vitanet ®

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Benefits of Alpha Lipoic Acid
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Date: October 13, 2005 05:08 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Alpha Lipoic Acid

Benefits of Alpha Lipoic Acid

  • Supports the Body’s Defense Against Free Radicals*
  • Recycles Antioxidant Nutrients such as Vitamin C and Vitamin E*
  • Helps Maintain a Healthy Blood Sugar Level when used as part of the diet*

    Alpha-lipoic Acid––the "Ideal Antioxidant"

    The antioxidant potential of a substance is based on a number of criteria, including:
    1) Ability to quench specific free-radicals.
    2) Ability to bind or "chelate" metal ions that can generate free radicals.
    3) Supports function of other antioxidants.
    4) Absorption/bioavailability.
    5) Concentration in tissues, cells and extra cellular fluids.
    6) Ability to function as an antioxidant in fatty and watery environments.

    The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes.

    As a team, ALA and DHLA come close to the ideal, for the following reasons:1,2,3
    1) ALA is easily absorbed when consumed orally.
    2) ALA is readily converted to DHLA in various tissues.
    3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals.
    4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions.
    5) ALA and DHLA scavenge free radicals in fatty environments and watery environments.
    6) DHLA recycles other important antioxidants.

    DHLA-regenerates vitamin C, vitamin E and glutathione

    Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants.

    DHLA is an essential component in the interaction between these antioxidants.4 Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form.3,5 The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells.4 DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes.6 Evidence from animal studies suggests that DHLA protects the brain against free radical damage.7

    Alpha-lipoic Acid and Blood Sugar

    Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA.8 In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved.9 In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells.10

    Scientific References

    1. Packer, L.. Witt, E., Tritschler, H. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995;19(2):227-50.

    2. Suzuki, Y., et al. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Comms. 15(5):255-63.

    3. Biewenga, G., Haenen, G., Bast, A. The pharmacology of lipoic acid. Gen. Pharmac. 29(3):315-31.

    4. Serbinova, E. Maitra, I., Packer, L. The synergy between vitamin E and alpha-lipoic acid--–possible relationship against oxidative stress in vivo. Life Chemistry Reports 1994;12:17-21.

    5. Bast, A. Haenen, G. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochimica et Biophysica Acta 1988; 963:558-561.

    6. Kagan, V. et al. Dihydrolipoic acid––a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992;44(8):1637.

    7. Prehn, J. et al. Dihydrolipoate reduces neuronal injury after cerebral ischemia. J Cereb Blood Flow Metab 1992;12(1):78-87.

    8. Jacob, S. et al. Enhancement of glucose disposal in patients with type-2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45(8):872-4.

    9. Jacob, S et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology & Medicine 1999;27(3/4):309-14.

    10. Estrada, D. et al. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-804.



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    Gotta Habit
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    Date: June 14, 2005 06:26 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Gotta Habit

    Gotta Habit

    by Catherine Heusel Energy Times, October 1, 1998

    Quitting a bad habit presents quite a challenge. Just ask anyone who's ever tried to give up cigarettes. Or alcohol. Or even coffee. You start out with the best of intentions but cravings can push you off the straight and narrow. The result: giving up a nasty habit often means regenerating your resolve and trying again. And again. And again. While some blame an inability to give up a bad habit on poor will power, in actuality, the tenacious chains of these habits may derive from the body as well as the mind. "People don't seem to realize the effects these substances have on the body," says Joan Mathews-Larson, Ph.D., director of the Health Recovery Center, in Minneapolis, and author of Seven Weeks to Sobriety. Dr. Mathews-Larson is one of a growing number of addiction professionals who stress physical recovery when giving up a drug, whether it's caffeine or cocaine. "You can't disrupt your internal chemistry for months or years on end and then expect your body to automatically bounce back," she says. "You have to give it some help."

    Breaking Off is Hard to Do

    The substances we love to overdo all share a common characteristic: they mimic or enhance the body's chemical messengers. Opiate drugs such as heroin, for example, are virtually identical to substances called endorphins, neurochemicals that the body produces to mask feelings of pain. (When an injured Kerri Strug performed her final Olympic vault, her endorphins enabled her to push past her protesting nerve endings.) Stimulants such as caffeine and nicotine can provide a "rush" similar to that produced by adrenaline and noradrenaline, the neurochemicals that provide the quick and excited feeling that swells down your spine during frightened or thrilling moments. On the other hand, some drugs (notably alcohol and cocaine) boost the activity of several different neurochemicals, including those that control sensations of pleasure. From a biological perspective, then, none of the drugs that people take are totally unfamiliar to the body. Your body makes similar chemicals all the time, in response to specific events and needs. "The main advantage of drugs is that they act powerfully and immediately," explains Andrew Weil, M.D., in his book, From Chocolate to Morphine: Everything You Need to Know About Mind Altering Drugs. "Their main disadvantage is that they reinforce the notion that the state we desire comes from something outside us."

    Serious Disadvantage

    Another serious disadvantage of drugs resides in their impact on the body's everyday neurochemical balance. Under normal circumstances, the body maintains its internal chemical environment on a fairly even keel. It may pump out oodles of adrenaline in response to a specific threat, like a near miss on the highway, but for every such scary "high" a corresponding low sets in: that rubbery-kneed sense of relief you feel when things calm down.

    Over time, the body mistakes the introduction of mind-altering, foreign chemicals as an excess of its own production of neurochemicals. As a result it slows down its own manufacture of these vital substances. So when you stop drinking caffeine or other stimulating drugs, the body finds its neurochemical receptors begging for relief: Cravings raise their ugly heads while so-called withdrawal symptoms raise your discomfort level. A general sense of ill health sets in until the body's natural production of neurotransmitter production reaches an acceptable level.

    Healthy Behavior

    Breaking a bad habit may be complicated by a lack of regenerative health habits. "A proper diet is pretty low on an addict's list of priorities," says Mathews-Larson. "Most of the people we see live on fast food and junk food." Many people trying to give up bad habits are attacked by the chemical and physical problems resulting from eating fatty foods and not exercising: their bodies are chemically and physically challenged from a poor lifestyle.

    Fortunately, recovery from a bad habit can be enhanced by balancing your diet, exercising and using nutritional supplements to straighten out your interior biochemical environment.

    "We target substances that are essential for maintaining optimal brain chemistry," points out Mathews-Larson. Foremost among these substances are a variety of amino acids that the body needs to rebuild its supply of neurotransmitters. In addition, nutrients such as B vitamins and vitamin C are often in short supply among those who indulge in addictive drugs and alcohol.

    Exercise and meditation are equally important to recovery, since both activities naturally prompt production of mood-enhancing neurochemicals. (The so-called "runner's high" is believed to result from endorphins and other neurochemicals stimulated by jogging.) More importantly, natural stimulation that pushes the body to create its own, endogenous supply of feel-good chemicals produces a longer sense of well-being than the transitory high induced by drugs and alcohol. "The potential for highs is always there, and many techniques exist for eliciting them," declares Dr. Weil. "Drug highs differ from other highs only in superficial ways."

    Natural Appreciation

    To experienced treatment professionals such as Mathews-Larson, kicking a long-standing habit depends on learning to appreciate the natural high of good health, through an overall healthy lifestyle. "It's not enough to just stop using the substance you abused," she contends. "You have to build a high quality of life for yourself, so you can fully enjoy every day."

    Recommended Reading: Seven Weeks to Sobriety, by Joan Mathews-Larson (Fawcett Books, 1997) Healing Anxiety With Herbs by Harold H. Bloomfield. (Harper Collins, 1998.)



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    Energy Cycles - Stress and lack of energy don't just frazzle your nerves
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    Date: June 12, 2005 02:09 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Energy Cycles - Stress and lack of energy don't just frazzle your nerves

    Energy Cycles by Sylvia Whitefeather Energy Times, August 2, 2003

    Feeling stressed out and exhausted from an overburdened schedule? Regenerating your personal energy necessitates defusing stress. Stress and lack of energy don't just frazzle your nerves; they can leave you depressed, anxious and vulnerable to a long list of health problems.

    According to J. Douglas Bremner, MD, a psychiatrist at Emory University, Atlanta, when your brain overcharges on prolonged stress, your body pays a heavy, tiring price.

    "If stress has effects on the brain and neurological function, then stress has effects on all parts of the body, including the heart, blood vessels, immune system and digestive system," says Dr. Bremner, author of Does Stress Damage the Brain? (Norton). "The long list of damaging effects can include heart disease, memory impairment, depression and even increased susceptibility to stroke and cancer."

    A Good Night's Sleep

    Although getting a good night's sleep is a basic part of lowering stress and boosting energy, many of us seem to be tossing and turning through an epidemic of insomnia. The fact that so many people appear to suffer from disturbed and unsatisfying sleep may signal not only a personal energy lack, but also a deeper health crisis developing on the horizon. Lack of sleep, along with stress, not only contributes to those lackluster afternoons of the blahs, but it can also derail your basic body rhythms, weaken your immune system and make you age quicker.

    Researchers at the University of Chicago report that lack of sleep may deplete your get-up-and-go by upsetting basic metabolic functions and interfering with hormones. Pretty serious stuff: When people in this experiment cut back their sleep time to about four hours each night, their bodies behaved as if they were twenty years older and they started showing signs of developing diabetes. These effects happened in only a week of missing sleep (The Lancet, October 23, 1999).

    The drastically reduced sleep schedule slowed the thyroid gland, reducing the production and action of thyroid hormones. As a result, metabolism slowed and the non-sleepers developed that awful sluggish feeling too many of us know and hate.

    Stress from lack of sleep also coaxed the adrenal glands into releasing extra amounts of cortisol, a stress hormone whose purpose is to force the body into providing short-lived energy boosts. But after a while the body flames out, its ability to cope with daily demands drained even further.

    "We found that the metabolic and endocrine changes resulting from a significant sleep debt mimic many of the hallmarks of aging," says Eve Van Couter, PhD, professor of medicine at the University of Chicago and director of the study. "We suspect that chronic sleep loss may not only hasten the onset but could also increase the severity of age-related ailments such as diabetes, hypertension, obesity and memory loss."

    And when are you are constantly short-changed of sleep, it builds up an accumulative effect. Particularly susceptible are busy parents, shift workers, menopausal women and college students.

    One way to take back your energy from this metabolic madness is to get twelve hours of sleep a night for a week. But aside from hitting the snooze button a few hundred times, a possible antidote to this cortisol nightmare may be vitamin C.

    Fight and Flight

    The human body, which evolved before the advent of split-level houses and SUVs, was built to survive life-threatening, physical danger. When it encounters modern-day stress, such as traffic jams and credit card bills, it releases extra cortisol, heightening the body's immediate ability to run or fight. As a result of cortisol release, senses go on high alert, heart rate speeds up, blood flow to muscles increases, and the immune system mobilizes to deal with what it thinks is an imminent crisis.

    However, unlike physical danger that rapidly resolves (either you get away from what's trying to harm you or it does you in), today's stress drags on and on (at least till the next exit on the expressway), and the cortisol in the body continues to circulate.

    The long-range result of persistent cortisol is a drop in energy, rampant fatigue and lowered immunity. You feel constantly tired and you get sick more often. You may also gain weight.

    But researchers at the University of Alabama at Huntsville have found that large doses of vitamin C "reduce...the levels of stress hormones in the blood and also reduce...other typical indicators of physical and emotional stress, such as loss in body weight, enlargement of the adrenal glands, and reduction in the size of the thymus gland and the spleen," according to P. Samuel Campbell, PhD (American Chemical Society, 1999). Dr. Campbell believes that our prehistoric ancestors probably consumed large amounts of vitamin C in a tropical diet rich in fruits. "If so, the physiological constitution we have inherited may require doses far larger than the present RDA (the amount the government recommends) to keep us healthy under varying environmental conditions, including stress."

    Iron Out the Fatigue

    If you are a premenopausal woman, a lack of iron may also be draining your body of energy. According to experts, as many as one of every five women who menstruate may suffer anemia caused by a lack of iron. This type of problem is also frequent in teenagers and during pregnancy. (But before you take iron supplements, talk to your health practitioner to make sure this is the source of your fatigue.)

    "Women with heavy menstrual flow have the greatest risk (of anemia)," points out Susan Lark, MD, in Healing with Vitamins (Rodale). Dr. Lark recommends eating more iron-rich foods (like organic red meat) even if you are not anemic, since a mild iron deficiency can drag you down into the doldrums.

    Vegetarians necessarily eat fewer iron-rich foods than do meat eaters. But if you take a vitamin C supplement when you consume such iron-rich vegetables as lima beans, pinto beans and spinach, your body can absorb more of the iron in these foods.

    The Krebs Cycle: Keep the Wheel Turning

    All of your cells make the energy that keeps you going. This process, a complicated chemical reaction called the Krebs cycle, transforms fatty acids and carbohydrates into ATP (adenosine triphosphate) for cellular energy. Mitochondria, small structures in each cell, are the centers of this energy production.

    Energy production requires oxygen. The more oxygen available to the cells, the more energy is produced. Deep breathing and moderate exercise are simple, quick ways to oxygenate the body and boost energy. That is why walking, jogging and other physical activity wakes up your brain and restores pep.

    If you've been looking for ways to feel more energetic, take a deep breath and go for a long walk before you sit down to your rejuvenating lima beans and vitamin C. And another thing...take a pass on those late-night TV shows. Sleep is more important.



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    Multiple - Why take them?
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    Date: June 09, 2005 08:52 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Multiple - Why take them?

    Multiples

    When designing supplements to provide the foundation of a complete nutritional program, Source Naturals devoted extensive research to making sure you get the most out of the nutrients you consume. We took into account a key factor other such products have overlooked: the fact that our bodies are challenged by living in the modern world.

    We are constantly exposed to stresses our evolutionary ancestors never faced: a daily barrage of pollutants in our air, our water, even our food supply. In recognition of this fact, Source Naturals has created products that not only supply essential nutrients, but also support our key organ of detoxification: the liver.

    Why Take A Multiple?

    The advantage of taking a high-quality multiple, rather than taking individual nutrients, is that nutrients often enhance the absorption and/or function of other nutrients. In other words, nutrients work together. The list of nutrient interactions in the body is seemingly endless. For example, vitamin C dramatically enhances the absorption of iron. Vitamin D enhances calcium absorption and reduces excretion of calcium by the kidneys. Magnesium and calcium have complementary actions, with both playing a role in neuromuscular transmission and activity as well as bone metabolism. Vitamin B-5 is crucial in metabolizing amino acids and plays a role in converting the amino acid tyrosine into the neurotransmitters epinephrine, norepinephrine and dopamine. And the list goes on. Many antioxidant nutrients in the body have synergistic relationships as well. For example, the amino acid N-acetyl cysteine and vitamin B-2 work together. N-acetyl cysteine is an acetylated amino acid that is an antioxidant in its own right and also a precursor to another potent antioxidant, glutathione. Glutathione is a key player in redox reactions in the body?a repeating loop of chemical reactions in which glutathione is shuttled back and forth between its oxidized and reduced states. In its reduced form (GSH), glutathione is a potent antioxidant. After scavenging free radicals, glutathione becomes oxidized (GSSG). But, by using a coenzyme form of vitamin B-2 called flavin adenine dinucleotide (FAD), the body can convert glutathione back into its reduced state so it can continue to scavenge free radicals.

    In a similar fashion, alpha-lipoic acid recycles the antioxidant vitamins C and E. And the mineral selenium performs similar functions in the body as vitamin E, as well as regenerating oxidized vitamin E.



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