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  Messages 1-80 from 80 matching the search criteria.
Benefits of Vitamin D-3 In The Body! Darrell Miller 8/5/23
The Importance of Vitamin B-12 Darrell Miller 11/5/22
Plant proteins found to help prevent Type 2 diabetes Darrell Miller 4/22/19
Ginger Oil: Fighting Inflammation And Other Healing Health BenefitsOf The Oil Darrell Miller 4/19/19
The science behind curcumin’s healing properties Darrell Miller 1/2/19
Eleuthero (Siberian Ginseng) Benefits to Boost Body & Brain Health Darrell Miller 12/17/18
Stop feeding cancer cells! This is the diet mistake you probablymake that can cause cancer VitaNet, LLC Staff 9/5/18
7 Reasons Why You Should Eat More Parsley - Health Benefits of Parsley Darrell Miller 5/7/18
Finding a market for hemp: More than 2000 acres of industrial hemp planted in Minnesota this year Darrell Miller 8/31/17
Add These 3 Things To Your Coffee To Fight Inflammation Darrell Miller 6/28/17
7 disease-fighting foods to incorporate into your eating habits Darrell Miller 6/1/17
Four nutritious ways to eat nuts Darrell Miller 1/11/17
Aspartame now being marketed as natural sweetener, name changed to 'AminoSweet' Darrell Miller 12/27/16
CoQ10 — A Nutritional Powerhouse for Mitochondrial Health Darrell Miller 12/27/16
Low-Carb Diet May Aid Your Metabolism Darrell Miller 12/14/16
Five vitamins you need to support your liver - Jakarta Post Darrell Miller 12/9/16
Calcium Supplements and the Heart: Clearing Up the Confusion Darrell Miller 11/26/16
Maca Root And Your Health Darrell Miller 9/28/16
Does Melatonin Decline As We Age? Darrell Miller 9/22/15
Ferrum Phosphoricum and Your Health Darrell Miller 6/26/14
A brief history of cinnamon bark oil and its benefits Darrell Miller 2/14/14
The Health Benefits Of Brazil Nuts Darrell Miller 2/3/14
Prevent Bone Loss Naturally Darrell Miller 11/17/13
Can Butcher's Broom Help Fight Varicose Veins? Darrell Miller 1/11/13
Korean Ginseng Root Extract Darrell Miller 12/14/12
Here are recommendations made by Dr. Oz. Darrell Miller 9/22/11
What Makes Organic Raw Almonds so Good for My Health? Darrell Miller 4/16/11
Why Should I Be Taking A Vitamin B-Complex? Darrell Miller 2/3/11
Vitamin D And Calcium - Phosphorus Absorption Darrell Miller 1/14/11
Vitamin D3 Darrell Miller 4/9/10
Agave Nectar Darrell Miller 4/8/10
Sweeteners Darrell Miller 4/8/10
Now foods and GMP Practices Darrell Miller 2/4/10
Cinnamon Bark Darrell Miller 10/15/09
Natural Sweeteners Vs. Artificial Sweeteners Darrell Miller 4/30/09
Multiple Vitamins Darrell Miller 2/4/09
Noni Fruit Extract Darrell Miller 11/22/08
Lutein 20mg (FloraGlo) Darrell Miller 9/26/08
Don’t Live With Pain, Live Pain Free – Curamin Is The Answer Darrell Miller 4/24/08
Celiac disease Darrell Miller 4/8/08
Urinary Incontinence and Overactive Bladder: The Silent Conditions Darrell Miller 2/7/08
Exotic Herbs From The Amazon Basin Darrell Miller 6/22/07
Vitamin D Shows Promise For Cancer Prevention… Darrell Miller 6/19/07
EpiCore Benefits Darrell Miller 4/9/07
Revita Darrell Miller 3/8/07
Betaine HCI and Pepsin Darrell Miller 1/28/07
Benefits - Supports joint function and tissue health* Darrell Miller 12/11/06
Magnesium May Help Reduce Inflammation… Darrell Miller 8/3/06
Wasabi Rhizome Cleanse - Supports Phase II Liver Detoxification - Wasabi Health Benefits Darrell Miller 8/1/06
Super Powerful Anti-Oxidants: Acai fruit, Green Tea, Mangosteen, Noni Fruit, and Pomegrana Darrell Miller 7/7/06
Lutein to fight age-related macular degeneration! Darrell Miller 2/27/06
Rutozym - Systemic Enzyme Supplement with Nattokinase Darrell Miller 2/22/06
California Proposition 65 (Prop 65) and Progesterone Cream Warnings Darrell Miller 2/17/06
Benefits of L-Carnitine Darrell Miller 2/12/06
Benefits of Acetyl-L-Carnitine Darrell Miller 2/12/06
Naturally enhanced powers Darrell Miller 2/10/06
Folic Acid: Strengthening the Immune System in the Elderly Darrell Miller 1/9/06
Thyroid Energy from Now Foods Darrell Miller 1/5/06
Astaxanthin - PHYTONUTRIENT ANTIOXIDANT Darrell Miller 12/28/05
Vitamin C FAQ's Darrell Miller 12/27/05
Glucosamine & Chondroitin - JOINT HEALTH Darrell Miller 12/22/05
7-Keto - Anti-Aging and Antioxidant Protection Darrell Miller 12/18/05
Super Cortisol Support Fact Sheet Darrell Miller 12/8/05
Nattokinase Fact Sheet Darrell Miller 12/8/05
OsteoBoron™ Fact Sheet Darrell Miller 12/8/05
Tru-E Bio Complex Darrell Miller 12/8/05
Psyllium Husk Fiber Fact Sheet Darrell Miller 12/8/05
Butterbur Extract Fact Sheet Darrell Miller 12/8/05
Carnitine Creatinate Darrell Miller 12/8/05
AHCC® Fact Sheet - from Now Foods. Darrell Miller 12/8/05
VitaBerry Plus+ Fact Sheet Darrell Miller 12/7/05
TMG Fact Sheet Darrell Miller 12/7/05
Allibiotic CF Fact Sheet Darrell Miller 12/7/05
Astragalus Fact Sheet Darrell Miller 12/7/05
Immune Renew Fact Sheet Darrell Miller 12/7/05
Expanding Waist Lines Darrell Miller 11/22/05
PepZin GI™ helps relieve occasional discomfort. Darrell Miller 9/20/05
Sytrinol can lower Cholesterol by 27% - 34% Darrell Miller 9/20/05
Curcumin - Turmeric Extract Darrell Miller 8/19/05
Benfotiamine raises the blood level of thiamine pyrophosphate (TPP) Darrell Miller 8/2/05



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Benefits of Vitamin D-3 In The Body!
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Date: August 05, 2023 09:10 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Benefits of Vitamin D-3 In The Body!

As we live in modern times, most people spend their days indoors or in offices under artificial light. This fact can help explain why many individuals are deficient in vitamin D. This vitamin is crucial for bone health, immune function, and overall body wellness. If you're looking for a way to improve your vitamin D levels, Solaray Vitamin D-3 supplement can be a suitable solution. Lets dive into the benefits of this product and how it can help you maintain your health.

Improved Bone Health

Vitamin D is essential for the absorption of calcium. Calcium is a critical element that our bodies require for strong bones. Thus, deficiency in vitamin D can lead to weak bones and fragile bone structures. Solaray brand Vitamin D-3 2000IU in Lemon flavor can supplement our bodies with enough vitamin D to enable sufficient calcium absorption and, in turn, strong and healthy bones & teeth.

Enhances Immune System

Our immune system is the first line of defense in protecting our bodies against diseases and infections. Vitamin D plays a pivotal role in the proper functioning of our immune system. Vitamin D boosts our white blood cells' activity, which helps combat infections and bacteria that may be detrimental to our system. Thus, supplementing with Solaray Vitamin D-3 2000IU can help improve your immune system's health and functionality.

Increases Dopamine/Serotonin Production

Dopamine/Serotonin are neurotransmitters that promotes positive thoughts, feelings of well-being, and happiness. Research has shown that maintaining optimal serotonin levels is essential for mental health and well-being. A Vitamin D-3 supplement can help increase serotonin production, leading to an improvement in mood and emotional regulation.

Boosts Mood and Mental Well-being

Vitamin D-3 plays a crucial role in mood regulation and warding off depression. It essentially works in the brain's mood centers and impacts the production of serotonin—a key hormone that stabilizes our mood, feelings of well-being, and happiness. Deficiency of Vitamin D-3 has often been linked with mood disorders, feeling of sadness, depression, and anxiety. By ensuring an adequate intake of Vitamin D-3, such as through supplements like Solaray Vitamin D-3 2000IU, you can maintain optimal serotonin levels, thereby improving your overall mood and promoting mental well-being. So, if you're feeling down more often than not, it might be a good idea to get your vitamin D levels checked and consider supplementation or more sunshine exposure.

Prevents Chronic Diseases

Deficiency in vitamin D has been linked to the development of chronic diseases such as multiple sclerosis, diabetes, and heart disease. Supplementing with Vitamin D-3 can reduce the risks of developing these diseases and improve your overall health.

Easy-to-take and Delicious Flavor

Solaray offers Vitamin D-3 2000IU in a Lemon flavor comes in a lozenge (under the tongue) form, making it easy and pleasant to consume. Hence, incorporating this supplement in your daily routine can be effortless and convenient.

In Summary: Supplementing with Solaray brand Vitamin D-3 can help boost your immune system, promote strong-bone-teeth development, enhance your mood, and prevent the development of chronic diseases. Additionally, the lemon flavor and lozenge form make it an enjoyable and easy-to-take supplement. Take care of your body and your health by incorporating a Vitamin D-3 supplement into your daily routine and feel the difference it can make in your life!

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6583)


The Importance of Vitamin B-12
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Date: November 05, 2022 10:41 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The Importance of Vitamin B-12

Vitamin B-12 is an essential nutrient that is involved in energy production, brain and nerve health, DNA replication, red blood cell production, and myelin sheath formation. While you can get vitamin B-12 from eating certain foods, many people don't get enough of this important nutrient and may need to supplement with a vitamin B-12 supplement like Source Naturals Vitamin B-12 Sublingual 2000 mcg.

Vitamin B-12 is an important nutrient for many reasons. This water-soluble vitamin helps to convert carbohydrates into glucose, which is used for energy production in the body. It also helps to form red blood cells and helps with the absorption of iron. Iron is important for carrying oxygen in the blood. Vitamin B-12 is also necessary for proper DNA replication and for the formation of the myelin sheath, which is a layer of insulation around nerve cells.

Vitamin B-12 deficiencies are common, especially among older adults, vegetarians, and vegans. Symptoms of a vitamin B-12 deficiency include fatigue, weakness, memory loss, depression, and nerve problems like numbness or tingling in the hands and feet. If you think you may be deficient in vitamin B-12, talk to your doctor about getting a blood test. A simple blood test can tell you if you are deficient in vitamin B-12 and whether or not you need to supplement with a vitamin B-12 supplement.

In Summary:

Vitamin B-12 is an essential nutrient that plays a role in energy production, brain and nerve function, DNA replication, red blood cell production, and myelin sheath formation.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6559)


Plant proteins found to help prevent Type 2 diabetes
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Date: April 22, 2019 04:18 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Plant proteins found to help prevent Type 2 diabetes





A recent study published in the British Journal of Nutrition analyzed the diets of more than 2,000 men. It specifically sought to find a correlation between protein sources and diabetes. It found that, in general, men with a higher intake of protein from plants were less likely to develop Type 2 diabetes. Conversely, men who got most of their protein from processed or unprocessed meats were more likely to develop Type 2 diabetes. Several other studies from Harvard have reached parallel conclusions.

Key Takeaways:

  • Researchers from the University of Eastern Finland looked at the dietary habits of 2000 men to try to learn the impact of protein sources on heart health.
  • Plant-based diets are associated with significant drops in the risk of Type 2 diabetes, even when subjects also are less healthy foods as well.
  • One serving of red meat per day is enough to substantially raise the risk of type 2 diabetes relative to non-meat eaters.

"According to the study, men who had the highest intake of plant proteins were 35 percent less likely to develop Type 2 diabetes compared with those who had the lowest consumption."

Read more: https://www.naturalnews.com/2019-02-17-plant-proteins-found-to-help-prevent-type-2-diabetes.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6149)


Ginger Oil: Fighting Inflammation And Other Healing Health BenefitsOf The Oil
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Date: April 19, 2019 01:43 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Ginger Oil: Fighting Inflammation And Other Healing Health BenefitsOf The Oil





Ginger oil is made from the versatile kitchen spice, and provides a wide variety of antibacterial, anti inflammatory and other health benefits. Ginger can help clear out your airway and soothe a troubled digestive system. You can also apply it topically to help relieve muscle and joint aches. Ginger oil is easy to make at home, and it retains the spicy taste of its main ingredient, making it an excellent addition to baked goods and other dishes.

Key Takeaways:

  • Ginger is an anti-oxidant and anti-bacterial agent, making it one of the healthiest spices available.
  • Ginger oil can help ease pain from inflammation and it promotes respiratory health.
  • Ginger can promote digestive health and be helpful in cases of food poisoning.

"Ginger is one of the healthiest spices you can add to your diet and all its healing properties are credited to the presence of the bio-active compound gingerol."

Read more: https://food.ndtv.com/food-drinks/ginger-oil-fighting-inflammation-and-other-healing-health-benefits-of-the-oil-2000177

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6141)


The science behind curcumin’s healing properties
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Date: January 02, 2019 05:17 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The science behind curcumin’s healing properties





Nature provides many healing aids, and this spice is among one of the more useful.it has been used for thousands of years to fight and relieve inflammation and has recently been proven effective in preventing oxidation in the circulatory system brought on by smoking and diabetes. It has also proven effective in the tumor reduction treatment in certain cancer lines, which reversing the effects of oxidative stress has shown remarkable progress in the treatment and prevention areas.

Key Takeaways:

  • Turmeric's long history as a culinary spice predates the appearance of Christ by more than 2000 years.
  • Curcumin is the innate part of turmeric which gives the spice it's well-known yellow color.
  • Curcumin has renowned ability as an anti-inflammatory, besides aiding the human heart by keeping cholesterol levels lower.

"Now, two studies published in the African Journal of Traditional, Complementary and Alternative Medicines have confirmed that curcumin also has potent antitumor abilities, in addition to protecting the heart against oxidative stress caused by diabetes and nicotine."

Read more: https://www.naturalnews.com/2018-12-30-the-science-behind-curcumin-healing-peoperties.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5922)


Eleuthero (Siberian Ginseng) Benefits to Boost Body & Brain Health
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Date: December 17, 2018 12:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Eleuthero (Siberian Ginseng) Benefits to Boost Body & Brain Health





Eleuthero is another name for Siberian Ginseng, an herbal remedy which has been used for at least 2000 years. It is distantly related to another, better-known herbal remedy, Asian ginseng. It is also sometimes called Devil's shrub, shigoka, touch-me-not, or wild pepper. Siberian ginseng is an adaptogen. Athletes use it to improve endurance and reduce fatigue. It is also used to treat chronic heart conditions, ADHD, high blood pressure, diabetes, kidney disease, colds and flu, among other conditions.

Key Takeaways:

  • Eleuthero, also known as Siberian ginseng, is a distant relative to the Asian ginseng, and it has been used medically for about 2,000 years.
  • The list of uses of eleuthero is very long. Athletes use it for endurance and reducing fatigue. It is also used for diabetes, kidney disease and flu.
  • The Siberian ginseng is native to Russia, northern China, Korea, and Japan. Other common names are Devil’s shrub, shigoka, wild pepper and Kan Jang.

"There are seven primary eleutherosides in eleuthero, with eleutherosides B and E being the most frequently studied. Siberian ginseng also contains complex polysaccharides, which are a main reason for its ability to boost the immune system."

Read more: https://draxe.com/eleuthero-siberian-ginseng/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5904)


Stop feeding cancer cells! This is the diet mistake you probablymake that can cause cancer
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Date: September 05, 2018 09:52 AM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Stop feeding cancer cells! This is the diet mistake you probablymake that can cause cancer





Stop feeding cancer cells! This is the diet mistake you probably make that can cause cancer

Although we tend to associate fashion with things like neckties, the truth is scientific ideas go in and out of fashion as well. Various pet theories their have their moment in the sun and then slip quietly below the radar as another more intriguing idea grabs everyone's attention. In the 2000s it was all about genetics and DNA. The Genome project, which would take on the lofty goal of mapping human DNA, thereby aiding scientists in their search to discover the mutations that lead to cancer, or so it was assumed. In actuality the search for causative mutations petered off into almost nothing. Some tumors had no mutations. Nor was there any sort of common DNA factor.

However, it hasn't proven to be a trek back to square one precisely. A Nobel prize winner back in the thirties had a theory that though not conclusive was compelling. This scientist, Warburg, surmised that when the body's mitochondrial cells produced energy as they were supposed to, which is aerobically, the body remains healthy. When energy production became anaerobic, a process that produces lactic acid in the body, then cancer cells would proliferate. To starve these renegade cells, the body would have to re-shift back away from the lactic-acid producing energy style, back to the more positive aerobic method. Some more recent scientists have started to build on Warburg's ideas, even discovering that sugar is a specific for cancer cells, without which they starve. So a best case scenario proposed diet for those with cancer would include high fats, less than fifty percent carbs, and a small amount of protein. Because of the relationship with sugar some diabetes drugs may have secondary use as a way to fight cancer as well.

Key Takeaways:

  • The Human Genome project, which was to map human DNA and discover all the causative mutations leading to human cancers began around the 2000s.
  • Unfortunately, scientists had not allowed for how random mutations are and no specific genetic cause of cancer could be tracked down.
  • Warburg, surmised that when human cells shifted from an aerobic style of energy production to an anaerobic style, then cancer cells proliferated.

"In 1931, Dr. Otto Warburg won the Nobel Prize Physiology or Medicine for his discovery that cancer cells have a fundamentally different energy metabolism compared to healthy cells."

Read more: https://www.healthnutnews.com/stop-feeding-cancer-cells-this-is-the-diet-mistake-you-probably-make-that-can-cause-cancer/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5747)


7 Reasons Why You Should Eat More Parsley - Health Benefits of Parsley
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Date: May 07, 2018 01:17 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 7 Reasons Why You Should Eat More Parsley - Health Benefits of Parsley





There are seven reasons why you should eat a lot more parsley. parsley has been cultivated by people for the last 2000 years. It was originally used for medicinal purposes only, but its use expanded over time. There are many nutrients that are found in parsley and it is one of the healthiest things that you can consume. Parsley will help your body a lot and it is great to relieve indigestion and help strengthen your digestive system.

https://www.youtube.com/watch?v=mWP9K55wNlg&rel=0

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5592)


Finding a market for hemp: More than 2000 acres of industrial hemp planted in Minnesota this year
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Date: August 31, 2017 04:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Finding a market for hemp: More than 2000 acres of industrial hemp planted in Minnesota this year





Growing industrial hemp to harvest for food, fiber and other uses is becoming more common especially in Canada. Now Minnesota wants to begin allowing the cultivation of Hemp. Thanks to legislations, Hemp crops have doubled in Minnesota in the last few years and are continuing to grow. The Ag and Renewable Energy Committee of the Kandiyohi County as well as the City of Willmar Economic Development Commission have been working hard to increase production to help farmers while assuring the public that there is no danger from getting high off this particular type of crop.

Key Takeaways:

  • Thousands of acres of industrial hemp were planted in Minnesota on the year. Find a market for hemp when trying to place a bulk order.
  • New buyers have shown interest in the hemp crop itself over time. These thousands of new acres are a good sign for growers.
  • Minnesota is proud of its agricultural heritage on the whole. Leaders want to make sure that the hemp plants are the right decision.

"According to the Minnesota Department of Agriculture, there is a 101-acre field of hemp being grown in Chippewa County."

Read more: http://www.wdaz.com/news/4318205-finding-market-hemp-more-2000-acres-industrial-hemp-planted-minnesota-year

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5201)


Add These 3 Things To Your Coffee To Fight Inflammation
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Date: June 28, 2017 11:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Add These 3 Things To Your Coffee To Fight Inflammation





Most people have a morning routine that usually involves making a pot of coffee, along with getting some breakfast. If you are a person that drinks coffee regularly you should think about adding a few things to your coffee to help boost flavor and help fight inflammation. chronic inflammation if not controlled can lead to other more serious health problems. There are a few things you can add to your coffee to help boost your inflammation fighting abilities, these include turmeric, ground pepper and cinnamon. Turmeric is filled with antioxidants and anti inflammatory. ground pepper helps significantly boost turmeric's anti inflammatory proprieties 2000 percent. Cinnamon also has anti inflammatory ablates along with a few other health benefits. By adding these ingredients everyday to your coffee will help significantly with inflammation.

Read more: Add These 3 Things To Your Coffee To Fight Inflammation

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4899)


7 disease-fighting foods to incorporate into your eating habits
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Date: June 01, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 7 disease-fighting foods to incorporate into your eating habits





Garlic and onions are one of the main vegetables that can fight diseases. Together they lower the risk of prostate cancer while beans offer the healthy benefit of vegetables while keeping the heart healthy. Ginger is a cheap and simple antidote that can cure diarrhea, the Chinese have been using Ginger to cure diarrhea for over 2000 years. Mint has many uses like it can be used to cure asthma anxiety and can make the face pimple free when used as a mask.

Key Takeaways:

  • These 7 foods aid in disease prevention and healing; garlic and onion, ginger, cinnamon, turmeric, beans, mint and citrus fruits.
  • Each of these foods contain nutrients and properties that assist with symptoms ranging from diarrhea, high blood sugar, high cholesterol and inflammation.
  • Eating these power foods will assist with preventing obesity, cancer, diabetes, Alzheimer's and many other diseases.

"Disease prevention can be as simple as being more mindful of the food you eat."

Read more: http://www.naturalnews.com/2017-05-25-7-disease-fighting-foods-eating-habits.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4748)


Four nutritious ways to eat nuts
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Date: January 11, 2017 01:39 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Four nutritious ways to eat nuts





Nuts are a proven healthy food. There are ways to enjoy the benefits of eating nuts in a way that makes them more enjoyable to eat then just eating them whole. You can enjoy them roasted eating them that way or srinkling on food, you can grind them and add to porridge, you can also bake them into pastries or blend them into healthy smoothies, all excellent ways to enjoy the health benefits of nuts.

Key Takeaways:

  • We explored the different kinds of nuts we have at our disposal and we got to know what a nutrient powerhouse nuts really are.
  • The good news is there are so many ways one can include these nutritious treats into their daily dietary intake.
  • Roast nuts for breakfast, nuts in porridge, nuts in pastry, and nuts in smoothies are all some tips to include them in your diet.

"No one said mandazis and chapatis can only be used made interesting using carrots and pumpkins alone."

https://www.google.com/url?rct=j&sa=t&url=https://www.standardmedia.co.ke/evewoman/article/2000227748/four-nutritious-ways-to-eat-nuts&ct=ga&cd=CAIyGjY3NzEzYzg1MjE0ZjUwYzU6Y29tOmVuOlVT&usg=AFQjCNFbEZ_M3k_DmzGHAppH02aVnnThaw

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3769)


Aspartame now being marketed as natural sweetener, name changed to 'AminoSweet'
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Date: December 27, 2016 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Aspartame now being marketed as natural sweetener, name changed to 'AminoSweet'





Artificial sweeteners are starting to come under a lot of scrutiny. One of the most controversial is aspartame, which some consider a very toxic substance. Since the public views this so negatively, they are attempting to get it back to market by changing the name. It will now be called AminoSweet, but it is just as dangerous.

Key Takeaways:

  • Since its initial discovery in 1965 by G.D. Searle Pharmaceuticals, aspartame has been the subject of considerable and unrelenting controversy.
  • Numerous peer-reviewed studies published in the 1980s revealed that aspartame has a damaging effect on the brain.
  • Since acquiring ownership of the aspartame business from Monsanto in 2000, Japanese drug company Ajinomoto has been working hard to rebrand and recreate aspartame in order to boost its acceptance by the public.

"Since acquiring ownership of the aspartame business from Monsanto in 2000, Japanese drug company Ajinomoto has been working hard to rebrand and recreate aspartame in order to boost its acceptance by the public."



Reference:

//www.naturalnews.com/056108_aspartame_aminosweet_chemical_sweeteners.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3709)


CoQ10 — A Nutritional Powerhouse for Mitochondrial Health
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Date: December 27, 2016 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: CoQ10 — A Nutritional Powerhouse for Mitochondrial Health





coenzyme Q10, which is referred to as CoQ10 is gaining popularity in the supplement marketplace. The number of Americans who are using this supplement has risen to twenty-four million people. This is good news as research shows its benefits. New research shows it keeps the mitochondria healthy, allowing for oxygen to be converted to energy.

Key Takeaways:

  • At present, at least 1 in 4 American adults over the age of 40 are taking a statin — ostensibly to protect their heart health.
  • This is the enzyme inhibited by statin drugs. This means that, in addition to lowering your cholesterol, the drug also compromises your body's ability to benefit from a healthy and cleaner-burning fuel (fat).
  • Recent research found that taking CoQ10 in combination with selenium improves heart function and cuts cardiovascular mortality by nearly 50 percent in elderly people.

"Between 2000 and 2016, the number of Americans using CoQ10 increased from an estimated 2 million to 24 million, and the number of brands featuring CoQ10 has increased from 18 brands to 125."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//www.prohealth.com/library/showarticle.cfm%3Flibid%3D29771&ct=ga&cd=CAIyGjVkYjY3ZDViNDdiNGM3ZTc6Y29tOmVuOlVT&usg=AFQjCNFStHXdUv1oYIMpcXavYYI0sc130w

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3707)


Low-Carb Diet May Aid Your Metabolism
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Date: December 14, 2016 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Low-Carb Diet May Aid Your Metabolism





Feeling a little sluggish? Think you could lose a few pounds? Well low carb may be just for you. New research shows that low card is supposed to upstart metabolism making it even easier to lose weight. This is on top of the benefit that low carb provides. Start today.

Key Takeaways:

  • Research suggests that eating low-carbohydrate meals may lead to healthy changes in a woman's metabolism.
  • The researchers also found that the timing of exercise may play a role in how beneficial it is for your metabolism.
  • Small changes can make a difference, such as watching the kinds of foods you eat and not exercising at an inappropriate time.

"Insulin is a hormone that helps the body use carbohydrates from food to fuel the cells in the body and brain."



Reference:

//www.medicinenet.com/script/main/art.asp?articlekey=200089

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3641)


Five vitamins you need to support your liver - Jakarta Post
TopPreviousNext

Date: December 09, 2016 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Five vitamins you need to support your liver - Jakarta Post





Your liver is one of your body's most metabolically active organs, meaning its energy demands are high. The liver, brain, kidneys and heart together account for about 5 percent of your body weight. Yet, these organs account for 60 percent of the energy your body consumes when you are at rest, according to the book "Principles of Clinical Gastroenterology." To keep you liver functioning efficiently, it needs a good supply of B-complex vitamins to assist it with the breakdown of carbohydrates, fats and proteins.

Key Takeaways:

  • Your liver is constantly working to filter hundreds of toxins found in your diet and environment. On top of that, your liver also helps to break down your food and provide energy to your other organs.
  • Although vitamin A has several benefits to offer someone with liver disease, it can be toxic to the liver in high dosages.
  • According to researchers from the University of Tennessee in Memphis, more than 90 percent of individuals with chronic liver diseases have some degree of vitamin D deficiency.

"Vitamin A and iron deficiencies are among the most common nutritional deficiencies worldwide, according to a study published in the 2000 issue of Nutrition."



Reference:

//www.thejakartapost.com/life/2016/11/25/five-vitamins-you-need-to-support-your-liver.html

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Calcium Supplements and the Heart: Clearing Up the Confusion
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Date: November 26, 2016 12:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Calcium Supplements and the Heart: Clearing Up the Confusion





The Institute of Medicine has recommended 1000-1200 mg of calcium daily for most adults, and the tolerable upper intake level has been set at 2000-2500 mg of calcium daily. Even a recent observational study from the MESA cohort suggested an association between calcium supplements and coronary artery calcium, but it is important to note that in observational studies, the association does not prove causation. In the large-scale Women's Health Initiative calcium and vitamin D trial, we found no association between calcium and vitamin D supplementation and coronary artery calcium measured at the end of the 7-year trial.

Key Takeaways:

  • We know that both calcium and vitamin D are essential for bone health, but concerns have been raised from selected reports in recent years about heart risk.
  • There are other reasons that there could be an association, such as overlapping risk factors for osteoporosis and heart disease, including smoking and lack of exercise.
  • There are many dietary sources of calcium, including dairy products (milk, yogurt, cheese), fatty fish with bones (such as sardines), fortified beverages, and leafy greens.

"We know that both calcium and vitamin D are essential for bone health, but concerns have been raised from selected reports in recent years about heart risk."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//www.medscape.com/viewarticle/871466&ct=ga&cd=CAIyGmU0N2NhMzY3ZTc4ODMzY2U6Y29tOmVuOlVT&usg=AFQjCNFQpRn2FPTRhKr-ZYi7jkxzioJqrQ

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Maca Root And Your Health
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Date: September 28, 2016 07:50 AM
Author: Darrell Miller
Subject: Maca Root And Your Health

Maca, (Lepidium meyenii) also Peruvian herb is a biennial herb indigenous to Andes, Peru. It’s also grown in Brazil and Bolivia. It’s cultivated for its fleshy hypocotyl and tap root which is a root vegetable and a medicinal herb.

Brief history

For over 2000 years, Maca root has been used by the ancient Incan culture for medicinal uses. They highly revered the plant for its legendary ability to offer mental clarity and energy as well as enhancing sex drive.

Today, Maca root is medicinal and health benefits such as:

  •  Hormonal balance to improve menopause and PMS symptoms in women as well as mood and fertility
  •  Improving sperm production, volume, and mobility in men
  •  Reduces enlarged prostates
  •  It’s used as an aphrodisiac to improve sex drive
  •  Increasing bone density especially in women

Maca root and Energy improvement

Maca contains vitamins, fatty acids, proteins, and minerals. These are elements to naturally support energy supporting as well as aid in injury recovery. Those who have used maca root in powder form have testified that it makes them awake, driven and energized. They even prefer it over caffeine as it doesn’t give jitters.

Clinical studies have revealed that maca is useful in maintaining positive energy levels and reducing anxiety and depression. It’s also important in regulating the hypothalamus, which improves the functioning of pituitary glands and thus balancing focus and energy. Researchers believe this is enhanced by balancing blood sugar levels.

Maca root holds many health benefits, if you are over the age of 50, you should be taking maca root daily to help balance hormones and feel better.


Reference URLs

https://draxe.com/top-5-maca-root-benefits-and-nutrition/

//www.globalhealingcenter.com/natural-health/7-benefits-of-maca-root-for-women/

//www.webmd.com/sex-relationships/guide/the-truth-about-maca

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Does Melatonin Decline As We Age?
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Date: September 22, 2015 01:00 AM
Author: Darrell Miller
Subject: Does Melatonin Decline As We Age?

Melatonin is a hormone secreted by the pineal glands.  The circadian production of melatonin is tied to the day/night cycle. Light through the retina signals the pineal glands to suppress its production. Lack of light stimulation (at night) results to increased production of melatonin. The increased hormone production at night is associated with a good night’s sleep. According to a study, melatonin significantly reduces sleep latency and increases sleep efficiency. It has thus been used to treat insomnia.

Sleep

Aging and Insomnia

Insomnia is commonplace among the elderly. As we age, sleep problems which include difficulty in falling asleep and maintaining the sleep are so rampant. This is so because melatonin production declines with age. With age comes the disruption of the circadian rhythms associated with the production of melatonin. To this end, melatonin supplements come handy to the elderly in maintaining a good night’s sleep.


Aging and Alzheimer's Disease

There is more to this hormone than a good night’s sleep and normal aging. There are evidences that melatonin suppresses Alzheimer’s disease. AD is the leading cause of dementia among individuals older than 65 years. Lack of sleep is a common symptom among AD patients and feels bad but sundowning (worsening of symptoms during evening hours) is worse. According to Netherlands Institute of Brain Research, the declining production of melatonin among the elderly not only affects the circadian rhythms but also enhances the development of Alzheimer.


Melatonin as an Antioxidant

Melatonin production starts to decline at age 60. This is the onset of diseases like AD which leads to increased production of free radicals in the brain. According to a review paper written in 2000, there is a lot of pathological changes among AD patients’ autopsied brains as a result of free radical activity. Melatonin carries antioxidant properties which fight the free radicals and protect the brain neurons.


Melatonin Supplements

Melatonin is a powerful hormone. Its function in sustaining optimal human health is crucial. New discoveries are being made on this versatile hormone. The fact that its production starts to decline at 60 only means that you need to use supplements and not fret over the onset of AD or insomnia. It is clear that besides being harmless and natural in treating insomnia, Melatonin is the most effective way of averting deleterious aging effects.



References

www.life-enhancement.com/magazine/article/1025-melatonin-can-reset-your-biological-clock

www.quora.com/Why-do-we-sleep-less-as-we-age

www.biomedgerontology.oxfordjournals.org/content/56/1/B21.full

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Ferrum Phosphoricum and Your Health
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Date: June 26, 2014 10:59 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Ferrum Phosphoricum and Your Health

iron foodsWhat is a Ferrum Phosphoricum?

Ferrum Phosphoricum or iron phosphate is a tissue salt used in Homeopathic medicine. It is derived from the combination of iron sulfate and phosphate. It also features prominently among the 12 Schuessler's Tissue Salts of Dr. Wilhelm Heinrich Schuessler. It is made by mixing iron sulfate, sodium phosphate, and sodium acetate. Then, this combination is ground to a fine powder and the resulting product is Ferrum Phosphoricum, which no longer retains any traces of the original compounds.

Iron


Iron is well known as being an important mineral for growth in humans and animals since it is responsible for blood formation, e.g., hemoglobin, and for oxygenizing tissues.

Phosphorus

Phosphorus serves its purpose by aiding in the development of bones and teeth and is considered to be a building block for certain B vitamins.

Ferrum Phosphoricum

Ferrum Phosphoricum is most often used where there is a need to fortify the blood, particularly the cell walls which transport blood. It is most commonly indicated at the beginning of an influenza or if there are feverish symptoms, after a period of prolonged bleeding, or for general malaise (weakness) where it excels greatly.

People suffering from anemia and/or issues connected with deficient blood are said to benefit immensely by taking Ferrum Phosphoricum.

Other indications for the use of Ferrum Phosphoricum are the following:

• Tonsillitis

• Fever

• Vertigo

• Sore throat

• Rheumatism

• Skin aliments

Generally speaking Ferrum Phosphoricum is beneficial for those individuals who have weekend or delicate immune systems, or who catch colds easily. It is most useful when given during the first stages of illnesses, particularly where there is heat, fever, or inflammation.

Part of the benefit of tissue salts and homeopathic remedies such as Ferrum Phosphoricum is that they are small, easily diluted and taste free. This makes them excellent for children and older individuals. Given the fact that they are quite inexpensive makes for all the more reason to give them a try. 

Sources

  1. //www.wisegeek.com/what-is-ferrum-phosphoricum.htm

  2. //www.remedysource.com/store/cell_salts/04-ferrum-phosphoricum.php

  3. //www.herbs2000.com/homeopathy/ferrum.htm

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A brief history of cinnamon bark oil and its benefits
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Date: February 14, 2014 09:34 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: A brief history of cinnamon bark oil and its benefits

What is cinnamon

cinnamon barkCinnamon traces its roots to the biblical times of Moses. It was imported to Egypt in the year 2000 BC by ancient travellers. It is one of the most valued herbs that is known to cure a variety of health complications.

Health benefits of cinnamon bark oil

The health benefits of cinnamon bark oil are attributed to the properties that it has. It is known to posses various beneficial properties. For instance, it is antifungal, antibacterial and antimicrobial. Cinnamon is also known to posses several beneficial minerals such as iron and calcium. Some of the treasured health benefits of cinnamon include:

I. Brain function

Cinnamon is one of the best products that can boost the activity of the brain. It aids in the elimination of memory loss and nervous tension. This ability was confirmed by a study that was conducted at the Wheeling Jesuit University in the USA.

II. Purification of blood

Cinnamon bark oil is a great blood purifier. This is why is normally used in treating pimples.

III. Circulation of blood

Cinnamon bark oil is the best product for those who intend to improve the circulation of blood in their bodies. Blood circulations are necessary since it aids in the transportation of oxygen and nutrients to all parts of the body. It is also important for the elimination of waste products.

IV. Pain relief

Cinnamon has always been prescribed for those who are feeling pain. It has anti-inflammatory properties that assist in getting rid of stiffness and pains in muscles as well as joints. Its anti-inflammatory property makes it an approved product for treating ailments such as arthritis.

V. Diabetes

Cinnamon bark oil can control blood sugar. According to a research study that was conducted in the United States, it was found out that cinnamon has special components that aids in the regulation of blood sugar.

VI. Control of infections

Cinnamon bark oil has anti-bacterial, anti-viral and anti-fungal properties which aids in the control of infections that result from bacteria.

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The Health Benefits Of Brazil Nuts
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Date: February 03, 2014 07:38 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Health Benefits Of Brazil Nuts

Brazil nut nutritional content

brazil nut fruitIf you are interested in improving your health, one of the most effective ways of doing it would be through increasing your intake of Brazil nuts. Most people don’t realize this, but these types of nuts have very high nutritional value and are beneficial for all kinds of people. They have a very high calorie count, which makes them one of the healthiest sources of energy you can find. It is estimated that 100 grams of Brazil nuts provide around 650 calories of energy. They also contain a high concentration of vitamin E, which is important in maintaining the integrity of human cells and is also a potent antioxidant. Selenium levels are also high in Brazil nuts, with 100g of the nuts having around 2000 micrograms of the element. This is more than enough for a single day. This trace element is a potent anti-oxidant, and has been shown to be very effective in protecting against diseases such as cirrhosis, some types of cancer and coronary artery disease.

Brazil nut minerals

One of the most remarkable things about these types of nuts is that they are gluten free. This means that they can safely be used by people who happen to have gluten sensitivity. Other minerals that are rich in the Brazil nuts include copper, manganese, potassium and phosphorus.

Benefits of brazil nut

Eating such nuts on a regular basis is therefore a good idea, since it exposes one to all the above. The good thing about them is that they don’t cost much, so you can benefit from all the above without having to spend a lot of money on them. When you consider the fact that they offer all the benefits above but without costing much, it’s easy to see that they are actually very good value for money. Including them in your diet, irrespective of your physiological status, is therefore a good idea.

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Prevent Bone Loss Naturally
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Date: November 17, 2013 02:16 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Prevent Bone Loss Naturally

What is Bone Loss

bone loss

Bone loss is the condition that results when the body cannot make new bone quickly enough to replace old bone that is broken down. Contrary to popular belief, bone is not just a solid structure, rather a living tissue that replaces itself through the process of destroying and creating new. If bone loss is not treated, the bones become very weak and are prone to break, a condition known as osteoperosis.

Risk Factors for Bone Loss

There are several different risk factors for bone loss and essentially osteoperosis. While this can include age, gender and even body composition, nutrition can also play an equally important role. Those who do not obtain enough Vitamin D, calcium or magnesium in the diet are more likely to suffer from this problem. However, there are several preventative actions and treatments which may be available.

Prevention and Treatment

Obtaining the recommended daily allowances (RDA) of calcium, Vitamin D and magnesium can help prevent and even aid in the treatment of bone loss. While milk is most often boasted for being the best source, this is not entirely so. First and foremost, not everyone enjoys or can tolerate milk and milk based products, meaning that this may not be the best option. Costly prescription drugs are an option, but these are not necessary.

An acidic body can draw out calcium and other minerals.  Eating lots of green vegetables along with taking a calcium supplement can balance the body and bring its pH up to the needed 7.0 - 7.3 that is needed for good health and wellness.

Alternate Remedies

Those that wish to prevent or obtain alternate treatment for bone loss will have a variety of options available to them. However, supplements may be the best choice for many consumers. Magnesium, Vitamin D and calcium supplements are an affordable option that are available over-the-counter. There are no amounts to keep up with, just a once-a-day oral form that is quick-and-easy. These products are perfectly safe and can be great for the lactose intolerant or those who simply are not a fan of milk. Recent studies suggest that we need a lot more vitamin D in the body.  2000IU to 5000IU are recommended on a daily basis.

References:

  1. What is Bone Loss? eMedicine, WebMD, 2013. Accessed 11, November 2013. //www.emedicinehealth.com/what_is_bone_loss/article_em.htm.

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Can Butcher's Broom Help Fight Varicose Veins?
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Date: January 11, 2013 12:36 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can Butcher's Broom Help Fight Varicose Veins?

Varicose Veins are abnormally thick veins that are twisted and enlarged. This problem occurs mostly in the leg and thigh veins. The thickened and twisted veins are called varicose veins. They can occur anywhere, but they mostly form in the legs because the legs work against gravity. Standing all day can increase the pressure on leg veins and cause varicose veins.

Causes

The normal function of veins is to carry blood from the outer body parts to the heart and lungs. The veins are provided with one-way valves, which prevent the blood from flowing backward within the vein. Defective or damaged valves are the main reason for varicose veins, as they allow the blood to flow backward, when it should be actually flowing up towards the heart. As the muscles contract to empty the veins, pressure builds up and this causes in the flow of more blood in the wrong way. Thus the pressure on the veins is increased and this causes varicose veins.

Factors that Aggravate Varicose Veins

  • * Pregnancy: During pregnancy, the blood volume increases and the growing uterus adds to the vein pressure in the legs, moreover, estrogen and progesterone relax the vein walls. All this lead to varicose vein formation during pregnancy
  • * Standing for long
  • * Obesity
  • * Straining: Any bodily condition, such as chronic cough, chronic constipation or urinary retention, which may cause strain can increase the chances for varicose veins.
  • * Age: Mostly elderly people are more prone to varicose vein occurrence.
  • * Surgery or trauma: Surgery can sometimes interrupt in the normal flow of blood.

Treatment

There are different types of treatments available to shrink varicose veins and to improve circulation, from simple home remedies to surgeries or medications for severe cases. Natural supplements like Butcher's broom are considered to be a very effective treatment for varicosities.

Butcher's Broom

Butcher's broom is a small, clump-forming evergreen shrub with tiny green flowers. It is an aromatic, diuretic and mildly laxative herb that helps reduce inflammation, increase perspiration and constrict the veins. The whole plant, young shoots and roots are used medically. Young shoots can be eaten like asparagus. It grows commonly in woodlands and hedgerows, and also on coastal cliffs. It is widely grown from Iran to the Mediterranean and the United States.

Its scientific name is Ruscus aculeatus, but it is commonly known as butcher's broom because butcher's used the stiff twigs to clean their cutting boards. The herb has been used for nearly 2000 years, but its medicinal uses have become common only from the last century. Investigations conducted in the 1950s indicated that butcher's broom can induce vasoconstriction and thus might be useful in treating circulatory diseases.

How It Works?

The two primary chemicals in butcher's broom, ruscogenin and neoruscogenin, can cause the blood vessels to narrow or constrict. Their anti-inflammatory properties help improve blood circulation in legs by preventing pooling of blood and reduce swelling.

  • * The flavonoids and ruscogenins in butcher's broom cause the vessels to constrict, reduce blood collection and protect the capillaries. It strengthens blood vessels and improves circulatory health.
  • * Butcher's broom helps the blood vessels to release the accumulated blood, and thus reduces the size of the veins.

Therapeutic Uses

Butcher's broom is used internally to treat venous problems that vary from varicose veins to hemorrhoids. It is also used to strengthen the veins and capillaries. Butcher's broom may be the best natural solution for varicose vein treatment, because it helps with blood flow and circulation.

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Korean Ginseng Root Extract
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Date: December 14, 2012 12:28 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Korean Ginseng Root Extract

Korean ginseng is a perennial herb that has been long renowned for its medicinal properties in curing various health disorders. Extracts of the root of this plant are made by dilution of one part of ginseng root with one part of water and alcohol.

The Korean ginseng root has been a staple ingredient in traditional Chinese medicines for more than 2000 years. This herb was considered a miracle drug by them, and the theory of its beneficial properties has been passed down through the ages. People still recognize the miraculous powers of this root, and use it as a natural antidote for various ailments. The ginseng root is generally, powdered only after six years of its growth and is made available in the form of extracts at stores all over the world. The Korean root is believed to comprise of various phytochemicals which are the main cause of all beneficial properties.

  • Ginsenosides, possessing steroid-like properties, increase the brain activity and act as a stress-buster.
  • Panaxans, have the similar structure as anabolic steroids, and can strengthen and build body muscles.
  • Polysaccharides, with a carbohydrate structure can boost mood, maintain blood sugar levels and promote cardiovascular health.

Benefits of Korean ginseng root extract

General health tonic

Ginseng is classified as an adaptogen, which acts as a complete health tonic. This extract can help the body rebound from fatigue, arising from various kinds of stress. It also aids in improving energy and physical endurance, thereby, contributing to the overall well-being of an individual.

Improves cardiovascular function

- This root extract can prevent organ and tissue prolapse, and improve blood circulation for improved cardiovascular function. It lowers the bad cholesterol levels and increases HDL cholesterol in the human body.

Improves functioning of the nervous system

The plant nutrients found in the herb extract can enhance the cognitive abilities and act as memory boosters. They can cure problems related to poor concentration, memory, insomnia and anxiety.

Diabetes control

The ginseng extract holds great promises for people with type-2 diabetes as it can result in greater glucose and insulin resistance.

Prevents cancer

Ginseng extract has also been proved to act as a preventive remedy for several kinds of cancer.

Immunity support

The extracts of this herb act as a stimulant for boosting the immunity and effectively prevent all kinds of flu and cold.

Korean ginseng root extract has worked miracles on improving the general well-being of a person. The numerous benefits of ginseng extract might seem compelling but it is advisable to exercise caution, as with other herbal supplements. Consult your physician before consuming ginseng to explore probable side-effects with existing medication.

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Here are recommendations made by Dr. Oz.
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Date: September 22, 2011 12:47 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Here are recommendations made by Dr. Oz.

FYI - Here are recommendations made by Dr. Oz.  See in blue the NOW Foods options.

1.    Vitamin D:

        - The only nutrient that's also a hormone

        - 60% of Americans are deficient

        - Helps immunity and cancers, especially colon cancer

        

item#

description

size

UOM

0357

VIT D 3 1000 CHEWABLE FRUIT FLAVOR

180

LOZ

0358

VIT D-3 5000 IU CHEWABLE MINT FLAVOR

120

LOZ

0363

Vit D-3 1000iu

90

SGELS

0364

Vit D-400 IU

180

SGELS

0365

Vit D-3 1000iu

180

SGELS

0366

Vit D-1000iu

360

SGELS

0367

Vit D-2000iu

120

SGELS

0368

VITAMIN D-1000iu VEGETARIAN

120

VCAPS

0370

LIQUID VITAMIN D-3 2000IU/0.5ML

2

OZ

0372

Vitamin D3 5000 IU

120

SGELS

0373

Vitamin D3 5000 IU

240

SGELS

0375

Vit D-3 1000iu

360

SGELS

0377

Vit D-3 2000iu

240

SGELS

0380

Vit D-3 Lipospray 1000iu

2

OZ

2.    Melatonin

        - Take if not getting enough sleep

        - 3 mg

        - Take 2 hours before bedtime

        - You should see a change in your sleep pattern within 1-2 weeks

 

3255

MELATONIN 3mg 60 CAPS

60

CAPS

3256

MELATONIN 3mg TWIN 2/60 CAPS

60 + 60

TWIN

3257

MELATONIN 3mg 180 CAPS

180

CAPS

3258

MELATONIN 3mg 90 LOZ

90

LOZ

3259

MELATONIN 3mg 180 LOZ

180

LOZ

3261

LIQUID MELATONIN 2 FL OZ

2

OZ

3262

MELATONIN 1mg TR COMPLEX 100 TABS

100

TABS

3263

MELATONIN 1mg TR COMPLEX 250 TABS

250

TABS

3555

MELATONIN 5mg VCAPS 60 VCAPS

60

CAPS

3556

MELATONIN 5mg VCAPS 180 VCAPS

180

CAPS

3.    Alpha Lipoic Acid

        - Increases energy

        - Slows the aging process

        - Helps with diabetes that affects 80 million Americans

3040

ALPHA LIPOIC ACID 100mg 60 VCAP

60

VCAPS

3041

ALPHA LIPOIC ACID 100mg 120 VCAPS

120

VCAPS

3042

ALPHA LIPOIC ACID 250mg 60 VCAPS

60

CAPS

3043

ALPHA LIPOIC ACID 250mg 120 VCAPS

120

CAPS

3045

ALPHA LIPOIC ACID 600mg 120 VCAPS

120

VCAPS

3046

ALPHA LIPOIC ACID 600mg 60 VCAPS

60

VCAPS

400 mg 3 times a day

keeps immune system strong

take as soon as symptoms develop

fights respiratory infections

NOW Foods Air Defense contains a patented form of Andrographis plus other lung supportive ingredients.  a GREAT formula for seasonal health and the frequent traveler.

4591

ANDROGRAPHIS EXTRACT 400MG 90 VCAPS

90

VCAPS

3372

AIR DEFENSE(R) CAPS 90 VCAPS

90

VCAPS

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What Makes Organic Raw Almonds so Good for My Health?
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Date: April 16, 2011 10:10 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Makes Organic Raw Almonds so Good for My Health?

Eat Organic Raw Almonds for Good Health.

Almonds are widely cultivated for its nuts, which are rich in vitamins and minerals. Throughout history, almond nuts have enjoyed a significant presence in many cuisines from all over the world. In fact, they are one of the best known nuts, rivaled only by peanuts in popularity. In recent years, almond nuts have been tied to alkaline diet, which consists of healthy foods touted to be alkaline-forming.Almonds Natural Unblanched

Prunus dulcis, the scientific name of almonds, is believed to have been domesticated earlier than the ancient times, with earliest evidence dating back to more than 2000 years ago in what is now known as the Early Bronze Age. This species is one of the ancient fruit-bearing trees grown commercially that remains popular to this day largely owing to its capacity to easily grow and bear fruits without the aid of grafting.

Organic almonds are different from other almonds grown the conventional way in that, as the name suggests, they meet the standards for organic farming, a method of food production that does away with chemicals known for their potential threat to the human health. In addition to being the only nuts considered alkaline forming, it contains higher levels of bioactive compounds noted for their nutritional significance.

Decreases Acidic By-Products

Almond, the only alkalizing nut, works on the principle of rebalancing the body’s pH. Proponents of alkaline diet believe that foods that are identified to be alkaline-forming aid the body in maintaining homeostasis and restore pH imbalances in the human body. It follows that foods that are acid-forming gradually contribute to the formation of diseases. Organic almonds, guaranteed to contain none of the chemical compounds known to produce acidic by-products, help rebalance the overall pH of the body.

Enhances Mental Performance

NOW - ALMOND FLOUR PURE   10 OZ 10 ozNuts have always been touted as foods for the brain. Organic almonds are different from other nuts because it is not even a nut in the first place. It is a drupe that contains a large seed, which is sold and consumed exactly like other nuts. These seeds contain an abundance of nutrients, such as magnesium, phosphorus, iron, B vitamins, and many others, all of which work hand in hand in increasing neuronal activities in the brain and the central nervous system, thereby enhancing mental performance.

Prevents Many Known Diseases

One cup of organic almonds is enough to meet the recommended daily intake for vitamin E and magnesium, two nutrients that have been the subject of extensive study in the past few years for their purported role in medicine. Vitamin E is an antioxidant that is pervasive at the cellular level. Magnesium improves health by raising the production of energy needed for cellular functions.

Organic almonds have been linked to the treatment of many different diseases, such as diabetes, cardiovascular diseases, cancer, and digestive problems. More importantly, they are one of the sources of food consistently recommended by experts on the alkaline diet.

Most importantly, raw almonds are full of nutrients and phytonutrients. Have you had your raw almonds today?

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Why Should I Be Taking A Vitamin B-Complex?
TopPreviousNext

Date: February 03, 2011 12:18 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Why Should I Be Taking A Vitamin B-Complex?

Vitamins are vital to life. They are essential organic nutrients that are required in very small amounts. Each vitamin is responsible for a certain metabolic function. Vitamins, except for Vitamin D, are not synthesized by the human body and thus are essential nutrients that must be provided through diet or supplements. Vitamins have two categories based on their solubility, the water – soluble and the fat – soluble. Water – soluble vitamins comprise of the B – complex vitamins, vitamin C and choline. On the other hand, the fat – soluble ones are vitamins A, D, E and K. In this article, we will focus on vitamin B – complex which are water soluble.

Vitamin B – complex include thiamine, riboflavin, niacin, pyridoxine, folate, cobalamin, biotin and pantothenic acid. These vitamins are crucial to many biologic processes:

Vitamin B-1 or thiamine is plays a role in energy metabolism and nerve functioning that is associated with muscular movement.

Vitamin B-2 or riboflavin also acts as a coenzyme in the release of energy from nutrients just like thiamine.

Vitamin B 3 or niacin is also very important in energy metabolism, specifically in glycolysis and tricarboxylic acid (TCA) cycle.

Vitamin B5 or pantothenic acid is involved in the normal growth and development of cells.

Vitamin B6 or pyridoxine acts as a catalyst in protein metabolism. This is essential in the development of nerve cells and normal functioning of the nervous system.

Vitamin B7 or biotin aids the transfer of carbon dioxide from one compound to another. It also assists the body to make hormones.

Vitamin B9 or folic acid helps maintain a healthy DNA and is required in the production of red blood cells (RBC).

Vitamin B12 or cobalamin is important in the growth and development of tissues and organs. It is also needed in the production of RBCs and nervous system functioning.

These vitamins are found almost in all foods, yet no one food is a perfect source of all these essential vitamins. Fruits and vegetables, cereals, meat and dairy products are great sources. Experts suggest that it is always best to consume vitamins from food sources. However, deficiencies may be rampant if you would just depend on dietary sources. These vitamins work hand in hand that an insufficiency in any B vitamin may result to poor functioning of any or all of the other B vitamins even if they are in good supply. Good thing, vitamin B – complex is made available to supplement the diet. These supplements come in capsule or tablet preparations. Inadequate levels of B vitamins may cause a feeling of weakness, tingling sensation and numbness in both upper and lower extremities, muscle cramps, hair loss, nail brittling, abdominal pain, depression, anemia, poor growth and development in children, and birth defects. As mentioned above, B vitamins are water – soluble. This means that the body cannot store this kind of vitamin except for vitamin B12 and any excess will be readily excreted in the urine. That’s why for those who are taking vitamin B – complex, it is safe and normal to have a bright to dark yellow – colored urine.

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Vitamin D And Calcium - Phosphorus Absorption
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Date: January 14, 2011 12:21 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Vitamin D And Calcium - Phosphorus Absorption

The human body is indeed a very complex system that needs various vitamins and minerals to sustain its vigor and life. One of the essential vitamins that is a must for our body to have is Vitamin D. The function of the said vitamin would sound very simple but if you ponder it deeper you will realize that beyond the simplicity lies its true essence and use.

The most vital function of vitamin D is for calcium and phosphorous absorption for bone and teeth growth. Not only that, it also aids in regulating the use and consumption of both minerals. To simply elaborate the vitamin’s mechanism of action, here goes the explanation. Adequate intake of Vitamin D could help your body decipher whether phosphorous and calcium will be deposited into your bones or would be discarded out of your system. Hence, for individuals who do not have sufficient intake of vitamin D, they would find it difficult to maintain homeostasis of the two essential minerals- calcium and phosphorous.

As early as now, we have to do our best and engage in different ways and means on how we can ensure that our body is getting enough vitamin D. It has been stated in several medical literatures that with adequate exposure to morning sunlight for approximately twenty to thirty minutes or an hour depending on the person’s skin tone, the body could generate its own vitamin D. the explanation for the difference in the required exposure is based on the fact that individuals who have dark colored skin has undeniably more skin pigments that could filter ultraviolet rays.

Because vitamin D is responsible in maintaining the health of your bones and teeth, a deficiency with the said vitamin would lead to a condition known as rickets. Rickets is characterized by bone fragility caused by depletion of calcium and protein deposits in your bones. However, as the golden rule dictates, too much of everything is bad. So if you consume too much of vitamin D, there would be a high probability that it will cause you a problem in your kidneys, heart and other vital organs brought about by calcium deposits.

Vitamin D can be found on the array of foods that we eat. Some food groups that contain high and liberal amounts of vitamin D includes: butter, milk, cod liver oil, cream, yogurt, tuna and egg yolks. However, despite of their high content of vitamin D, extra caution must be employed in eating such foods for it contains high level of bad cholesterol that is very detrimental to one’s body which in the long run would bring you to an undesirable state of health. Another wonder that vitamin D brings is the capacity of slowing down the growing number of cancer cells and in preventing grave illness such as multiple sclerosis, psoriasis diabetes mellitus and arthritis.

Solaray - Ultimate Nutrition - Actipet Pet supplements - Action Labs - Sunny Greens - Thompson nutritional - Natural Sport - Veg Life Vegan Line - Premier One - NaturalMax - Kal

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Vitamin D3
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Date: April 09, 2010 10:47 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Vitamin D3

Vitamin D3 does more than just strengthen your bones, new and continuing research suggests that up to 2000 different genes are targeted by this nutrient.* Vitamin D3 promotes health and wellness throughout your body, including increasing calcium absorption for stronger bones and boosting immunity.* without enough vitamin D, your body may be working far below its potential. And chances are, you are not getting enough.

Research suggests that healthy individuals who do not get a lot of sunlight may need to supplement with vitamin D3, every day. Vita net offers vitamin D3 in 1000, 2000, and 5000 I U which will provide the boost your body needs to stay at its peak.*

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Agave Nectar
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Date: April 08, 2010 04:31 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Agave Nectar

Agave Nectar Light Certified Organic 17 oz from NOWComments by Craig Gerbore, CEO of Madhava:

Reading through the attack articles and blogs that have surfaced recently one could think that using agave is bad for one's health. These claims are utterly false and misleading. They are extreme views drawn from extreme examples and applied way out of context. They are propagandizing and clearly designed to frighten, not educate. All of the fears and concerns associated with the overconsumption of sugars and calories in general have been unfairly cast on agave.

What is a "healthy" sweetener? One that you use moderately and sensibly.

Health concerns related to fructose and caloric sweeteners are all dependant on the overconsumption of them. All foods have calories and it is the overall consumption of calories that lead to obesity and related issues, not any one food source.

Agave's caloric value is comparable to the other sweeteners in the category. Due to its greater sweetness though, less agave is used compared to the others, so agave actually can reduce caloric consumption per serving. This is due to a higher fructose content. The higher content does not mean higher consumption though, due to the smaller portion used. But, it is not the single serving that matters, it is the number of servings which lead to the overconsumption issues which may result in health concerns.Agave Nectar Amber Certified Organic 17 oz from NOW

As a reference point, 9-10 teaspoon servings of agave would be the approximate caloric equivalent of one 16 oz soft drink. With this perspective, is agave really being overconsumed as a choice of sweetener for home use?

Every single health issue which the attackers have tried to associate with agave is really the result of a caloric overconsumption issue. There are no documented issues with normal, moderate consumption of agave or sweeteners in general as part of our everyday diet. For reasons unknown, some have attempted to isolate agave from the real world and real world conditions with the goal of inhibiting agave's use. They play on people's fears, reference false information and fail to address health issues in any meaningful way.

The purpose of this article is to debunk the controversial misinformation surrounding agave. All information debunking the myths and misinformation is based on current science and facts. It is our goal to provide you with useful information so that you can make your personal nutritional choices in a well-informed, science-based manner.

The Agave Controversy: Exposing the fraudulent article by Rami Nagel

By Dr. Susan Kleiner, PhD, RD, FACN, CNS, FISSN

And Craig Gerbore, CEO Madhava

The controversy about agave syrup was manufactured by the publication of a single article on the internet, which has been reproduced and adapted for virtually every other article produced on the internet and other media venues. That article, written by Rami Nagel and published on Naturalnews.com, was highly biased and full of inaccuracies, half-truths and misinformation about agave. Since the Naturalnews.com article has been the sole source of nearly all other popular articles in public media, we want to set the record straight with science-based, reliable information to offer a more balanced resource to those interested in learning more about agave syrup. Organic Blue Agave Nectar 16 Liq from FunFresh Foods Who is the author, Rami Nagel?

According to the description on the Naturalnews.com website, Rami Nagel is a "citizen journalist". This means that Mr. Nagel is self-employed, and not employed as an in-house journalist by the website. He wrote and published the article without any editorial or content oversight, and the editor of the website, Mike Adams, makes it clear that the article was not checked for incorrect or inaccurate information or facts. The introduction to the article, written by Mr. Adams, states that readers had written to comment that Mr. Nagel's resources were biased with conflicts of interest due to their financial interests in competing sweeteners, such as brown rice syrup. So even the website editor himself states that the article is not fact-checked, and it is biased and unbalanced.

Who is Russ Bianchi?

The sole resource interviewed for the article is Russ Bianchi, identified by the author as Managing Director and CEO of Adept Solutions, Inc. Mr. Bianchi has clear conflict of interest ties to the sweetener industry. We have documentation of the fact that Mr Bianchi had plans to market a product named Replace. It was to be touted as a low calorie alternative sweetener composed of natural and artificial ingredients! Mr Bianchi was prevented from marketing this sweetener as the result of a lawsuit against him by the owner of the formula.

Mr Bianchi is quoted by Nagel extensively and exclusively. Many, if not all, of his statements are blatantly false or misrepresentations of fact. He is clearly propagandizing against agave nectar.

Was anyone else interviewed for this article?

Yes. Craig Gerbore, president and owner of Madhava Agave Syrup, was extensively interviewed by the author but no parts of that interview were included in the article. Organic Maple Agave Nectar 16 Liq from FunFresh Foods

It is important to note that neither Mr Nagel or Mr Bianchi have not made themselves available for questions on their statements since the articles appearance. They remain out of sight and have entirely avoided the controversy their statements created.

What is agave nectar?

The opening line of this paragraph in the article by Mr. Nagel states:

"The principal constituent of the agave is starch, such as what is found in corn or rice."

This is absolutely false. There is no starch in agave. The source of carbohydrate in agave syrup is inulin, a polysaccharide made up primarily of strings of fructose units. Starch is a polysaccharide made up of strings of glucose molecules. They are significantly different, and this difference is why agave syrup is naturally sweet.

The very basis of the argument presented by Mr. Nagel is false.

The Process

The agave plant is a succulent, similar to a cactus. The agave sweetener comes from both the Salmiana agave plant and the agave Tequilana (Blue Agave) which are both organically farmed in Mexico and certified organic by USDA approved certifiers. As the salmiana plant grows it produces a stalk called the "quiote" and when this is removed, a natural liquid called "aquamiel". The liquid is collected from the plant, while Blue agave pinons are harvested and shredded to remove the similar juice. Either can be naturally processed thermally or by enzymes into agave nectar.

The juice of the plant is not naturally sweet. The string of connected fructose units that makes up the major proportion of inulin does not have a sweet taste, but when the fructose units are separated (the process is called hydrolysis) by the addition of an enzyme, similar to digestion, or thermally for most blue agave, the syrup becomes quite sweet. That is the entire processing chain for agave nectar. There are no additives, other ingredients or chemicals in Madhava agave nectar. It is absolutely pure and organic and GMO free.

? Mr. Nagel claims that agave syrup is a "refined corn fructose" similar to high fructose corn syrup. This is absolutely false. There is no relationship between agave syrup and high fructose corn syrup in any way, including the source of the product, or the manufacturing process.

? Mr. Nagel refers to a "confidential FDA letter" from Mr. Martin Stutsman, claiming that agave is fraudulently labeled. We contacted Mr. Stutsman at the United States Food and Drug Administration, and his response made it clear that there was never a "confidential FDA letter". He did publish a public letter referenced in an FDA document as "FDA letter from Martin Stutsman to Dr. Eric

Wilhelmsen (Wilhelmsen Consulting), May 8, 2000", regarding evaporated cane juice, a topic wholly unrelated to agave syrup.

? He continued in his response to us that the paragraph in Mr. Nagel's article inaccurately reflected the substance of his comments in the document.

This link will take you to the original document in which the letter was referenced (reference #2):

//www.fda.gov/Food/GuidanceComplianceRegulatoryInformation/GuidanceDocuments/FoodLabelingNutrition/ucm181491.htm

In fact, Mr. Nagel fabricated the entire story of the letter. Mr. Stutsman is a lawyer, not a doctor. The quotes were completely taken out of context from the document, and the quotes never referred to agave syrup at any time. Nagel goes on to further misrepresent Mr. Stutsman's intent in the published document by weaving in other inaccurate information that is thoroughly unrelated to the original document. Mr Bianchi's subsequent statements on labeling issues are false and without merit.

Mr. Nagel is clearly caught red-handed. He has misrepresented the words of a government official, lied about the facts, and twisted the information to achieve his own agenda. This strategy is repeated throughout the article.

? Mr. Nagel continues his deceptive writing by referring to a quote by the late Dr. Varro Tyler in his book, The Honest Herbal. The first line of the paragraph is a direct quote from the book. Nothing else in that paragraph remotely resembles anything else found in Dr. Tyler's book. Mr. Nagel is trying to claim that agave syrup contains large quantities of saponins, and that they can be harmful to health. Here is the debunking of that paragraph:

1. Dr. Tyler does not include the variety of agave plant used for agave syrup.

2. The entire discussion is about the use of the sword-shaped leaves and the stem. Agave syrup is produced from the natural liquid in the plant. The saponins are isolated from the leaves of the plant.

3. There is no documented evidence to suggest agave syrup contains worrisome levels of saponins and the entire rest of the discussion about health dangers is fabricated and false.

Sugars

People are going to continue to consume sweet food and drink. There are only three categories of choice to sweeten food. Those are artificial sweeteners, stevia, or caloric sweeteners from natural sources, sugars.

Most people will not choose artificial. Many will not choose stevia. That only leaves the category of sugars. In this group, agave is a good choice due to its organic quality, ease of

use, neutral flavor, low glycemic index and the fact that less is used to equal the sweetness of the others in the category.

The sweeteners in this category are composed of three primary sugars used to sweeten foods: glucose, fructose and sucrose. These sugars belong to a class of compounds known as carbohydrates. "Saccharide" is a term that denotes sugar, or substances derived from sugar. Monosaccharides are simple or single sugars; disaccharides are derived from two joined monosaccharides and when they are hydrolyzed, or separated, they yield two molecules of simple sugar. Strings of more than two sugar molecules are called polysaccharides. This category includes compounds such as starches, cellulose and inulin.

Glucose and fructose are monosaccharides. Glucose and fructose are found abundantly in nature in fruits and plants. Sucrose is the disaccharide formed by the joining of glucose and fructose, also known as table sugar. When comparing their relative sweetness, glucose is the least sweet tasting, sucrose is next, and fructose is the sweetest of the three sugars, measured as 1.4 times sweeter than table sugar. Because it is so sweet, people typically use less fructose when sweetening foods compared to sucrose.

? In the article by Mr. Nagel he states , "fructose is not what is found in fruit. Commonly, fructose is compared with its opposite and truly naturally occurring sweetener, known as ‘levulose' (made by nature)..."

Another fabrication. In fact, levulose is just another name for fructose. There are various nomenclatures used in the scientific naming of compounds. Fructose and levulose are exactly the same thing; the names are interchangeable. It is no different than if you called your father, "dad", and your sibling called your father, "father". He would still be the exact same person. Fructose and levulose are different names for the exact same thing: a sugar found in nature.

Mr. Bianchi also is quoted to say that the body does not recognize the fructose in agave. This is another false piece of propaganda which demonstrates just how far he is reaching. If this were true, it would have no impact on us. He immediately contradicts himself with the claims of detrimental effects caused by the overconsumption of fructose.

Using Sugars

Sugars can be compared to each other in their ability to raise blood sugar levels by using the Glycemic Index. The scale is set from zero to 100, where low numbers do not have much impact on blood sugar levels, and high numbers raise blood sugar levels quickly. Fructose is very low on the scale. Because agave syrup is high in fructose, it has a rating of 32 or lower. Honey, which has a higher proportion of glucose to fructose, has a Glycemic Index of 58. Sucrose has a Glycemic Index of 68, and glucose, serving as the index standard, is 100.

All sugars, whether fructose, glucose, sucrose or others, contribute 4 calories per gram to our total diet. 1 teaspoon of sugar = 4 grams = 16 calories

In addition to calories, sugars sweeten our foods offering a desirable taste and adding enjoyment and pleasure to our dining. During cooking and baking, sugars allow for browning and the unique consistencies of syrups, candies, frostings and frozen desserts. The varieties of sugars, such as crystallized table sugar, brown sugar, raw sugar, molasses, honey and agave nectar, among others, contribute different properties and flavors to foods.

When you add your own sugar to foods you are in control of how much sugar you use. Most people would never add as much sugar as do the food manufacturers. Moderate amounts of sugar can certainly be enjoyed as part of a healthy diet for an active individual. Natural sugars are easily metabolized and utilized by the body, offering a very efficient source of fuel for physical and mental activity.

Of course, sugars should be used in moderation in the diet. This can control calories and help create a diet that is dense in nutrients.

Impact of sugar on health and disease

? The remainder of Mr. Nagel's article works to link agave syrup with the increased incidence of obesity, diabetes, metabolic disease, and the general rise of morbidity and mortality in the population. This is an overconsumption issue involving far more than the occasional use of agave. Here are the facts:

• Rats that are fed a high fructose diet become obese and will develop the chronic diseases associated with obesity: insulin resistance, diabetes and metabolic disease.

• No one should eat a diet that reflects this type of experimental diet.

• Too much sugar in the diet, whether from fructose, glucose or sucrose, can be unhealthy. Diets high in sugar promote tooth decay and periodontal disease; create an overabundance of calories and a deficit of nutrients. This scenario typically leads to weight gain and the development of chronic disease.

• Active individuals can include a moderate amount of added sugar in their diet without negative health consequences. When calorie intake is balanced with physical activity, sugar serves as an efficient source of fuel for muscles, the brain and the central nervous system.

• According to the World Health Organization (2003), individuals can healthfully include 10% of their daily calories from added sugars. This translates into 200 calories for a 2000 calorie diet, or 12½ teaspoons of added sugar daily. Clearly, one can safely add a couple of teaspoons of sweetener to a cup of tea or coffee, or have a little sweetened food without worrying about their risk of developing disease.

• Agave syrup, which is sweeter than other sugars and low on the Glycemic Index scale, is a good choice to include as one of the added sugars in your diet because you will use less sugar (and therefore fewer calories) and minimally raise blood sugar levels.

Just a teaspoon of agave: the healthy use of sweeteners in your diet

We all want to live healthier and longer lives. Diet and nutrition plays a key role, impacting our health and our ability to perform physically and mentally now and into the future. Food offers us not only sustenance, but also pleasure and enjoyment. Food is present in so many parts of our lives: at celebrations, business events, family events, religious and spiritual occasions, sports outings, the focus of our family meals, intimate dinners, and sometimes just the excuse to socialize.

Sweet foods make us feel good. Sugar allows for the elevation of serotonin in our brains, the "feel good" neurotransmitter that elevates mood, helps us focus, and in the evening, helps us relax and sleep.

Sugar is a source of energy for our muscles, brain and central nervous system. Without sugar our bodies will not function at peak capacity.

Too much sugar, however, is not good. In small amounts sugar energizes us, but in large doses, repeated throughout the day, day in and day out, sugar puts stress on the body. The extra calories can lead to weight gain and obesity, which in time can lead to chronic disease. In the short term, high sugar intakes can lead to a nutritionally deficient diet and a sense of being on an emotional roller coaster.

So be selective about your use of sugars and use them in moderation in your diet. Just like all foods, a variety will enhance the nutritional content of your diet and the flavor and tastes that you can enjoy. Since sugars come in different forms and have different flavors, they can be used most effectively in specific foods and beverages. For instance, agave syrup is liquid and less viscous than honey, making it easy to mix into cold liquids like iced tea and coffee, and is great to add to cold unsweetened cereals for a little sweet taste. Agave's mild flavor allows chefs and bakers to sweeten foods lightly, without overpowering the taste of the dish.

Pay attention to how much sugar is added to your diet every day. Read labels so that you know when sugar is added to manufactured foods. Keep the consumption of added sugars in your diet to no more than 10% of your total daily calorie intake so that you have plenty of room for nutrient dense foods like fruits, vegetables, grains, dairy, protein-rich foods, nuts, seeds and healthy oils.

Remember that nutrition is a science based on facts. We are making great advances in our understanding of the science of foods and nutrition. Beware of people with hidden agendas using fear tactics to influence your choices. Don't take their opinion at face value. What are their credentials? What conflicts of interest do they have? If they do not disclose conflicts, then assume that they are manipulating the truth.

Most of all enjoy food. Think about what you need to eat to promote whole health. Don't overindulge, but don't deprive yourself of the bounty of wonderful tastes, either. Use celebrations as occasions to enjoy your favorite foods and try new ones. A teaspoon or two of sugar easily fits into the diet of an active, healthy person. Agave syrup offers an organic low-glycemic choice for those looking for that option.

Resources for this article:

Charley H. Food Science, 2nd Edition. John Wiley & Sons, New York, NY, 1982.

Figlewicz DP et al. Effect of moderate intake of sweeteners on metabolic health in the rat. Physiology and Behavior 98:618-624, 2009

Johnson RK et al. Dietary sugars intake and cardiovascular health: A scientific statement from the American Heart Association. Circulation: Journal of the American Heart Association, 2009

Tyler VE. The Honest Herbal, Third Edition. Pharmaceutical Products Press, New York, NY, 1993.

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Sweeteners
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Date: April 08, 2010 04:15 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Sweeteners

There are only 3 categories to choose from when sweetening: sugar sweeteners from plant sources, artificial sweeteners, and stevia.

Most people will not use artificial sweeteners and many will not use stevia. This only leaves the sugar sweeteners category, and among these, agave has some advantages and is a good choice.

All sweeteners in this category also have some similar characteristics and all add to the overall total consumption that can have an impact on health. Moderation in the overall consumption of sweeteners in ones diet is the important point.

People may not realize that sugars are essential to our body and are an important part of one’s diet. The problem being that affinity for sweets leads to overconsumption.

What is overconsumption?

It is based on caloric intake and includes all caloric foods and is also related to the level of physical activity. The USDA recommends an average diet consumption of 2000 calories. As a portion of this overall consumption, added sweeteners should constitute approx 10% of that intake, 200-250 calories daily.

Agave has 20 calories per teaspoon. The caloric value is similar to other sweeteners, but less agave is required to reach the same sweetness level, so relatively fewer calories are consumed per serving.

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Now foods and GMP Practices
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Date: February 04, 2010 12:36 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Now foods and GMP Practices

Author: Michael Lelah, Ph.D, Technical Directory, Now Foods

It should come as no surprise that 2009 was a challenging year with regard to the timeliness of order delivery, not just at NOW, but on an industry-wide scale. Many of the brands you carry have not been able to meet your demands.

In 2009 all medium-sized dietary supplement manufacturers, including NOW Foods, were officially required to meet the FDA's new dietary supplement cGMPs (current good manufacturing practices). NOW has placed very high quality standards on our products, and has been certified by NPA's stringent GMPs since 2000. Now that the FDA has started auditing manufacturers in our industry, we have found that the FDA requirements for the cGMPs are more strict than the early interpretations of experts.

This has resulted in ourselves and our industry being less prepared than anticipated, affecting the order fulfillment rates of many companies. We are actively working to respond to this.

Let's review the new FDA cGMPs. Good Manufacturing Practices, or GMPs, are manufacturing control systems designed to ensure that health products are manufactured in a consistent and safe manner. Standard operating procedures, specifications for all ingredients and products, and lab testing are cornerstones of GMPs. The FDA cGMPs are considerably rigorous, and by the FDA's own estimates, 25% of the brands you carry could be out of business as a result of not being able to meet their new cGMPs. Moreover, even for reputable brands, there is a lack of clarity on what the FDA expects, as much of this is new.

You might be wondering what all of this has to do with your orders? We at NOW Foods, along with other reputable manufacturers have increased our quality control efforts to meet the new FDA cGMPs. There are more requirements for ingredients and finished products, more documentation and more testing. The breadth of NOW's product line requires testing of thousands of ingredients. Based on the extensive nature of these efforts, coupled with disruptions in the supply chain, your orders have most likely been affected.

We are now better prepared to serve you. We are taking the safety of our products to entirely new levels and doing everything in our power to expedite the delivery of NOW products to your door.

Here are just a few examples of what we're doing:

  • We've implemented new systems and processes that meet the FDA's additional cGMP requirements
  • We've developed a new state-of-the-art screening method for melamine, weight loss drugs, steroids and erectile dysfunction drugs. This is specifically designed to assure the safety of our products while retaining our commitment to natural.
  • We've developed specialized methods to ensure the accurate identification of some ingredients that were once considered difficult-to-verify.
  • We're expanding our industry-leading microbiology testing procedures and facilities to further improve consumer safety.
  • We're working with our suppliers to minimize disruption to the supply chain
  • We're implementing a new stringent Supplier Quality Verification program to further ensure the quality of our ingredients and raw materials.
  • We're adding more manufacturing capacity, additional operators and technicians to meet increased demand as your business grows.
  • We've improved our order fulfillment processes by upgrading our operations processes. This will better ensure that your orders arrive on time and complete.

Here's what you can expect from NOW Foods in 2010:

  • Enhanced security and safety of products
  • Improved delivery over 2009
  • Even greater product quality
  • Receive a higher percentage of complete orders over 2009
  • Even higher service levels

At NOW Foods we are continuing to work hard to meet your needs, despite the increased challenges to our supply chain. We hope and anticipate that as we move into 2010, you will reap the benefits of our quality and fulfillment efforts.

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Cinnamon Bark
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Date: October 15, 2009 10:44 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Cinnamon Bark

cinnamon treeThe cinnamon plant is a small evergreen tree that grows between thirty two and forty nine feet tall. This plant belongs to the Lauraceae family and is native to Sri Lanka. The leaves of the plant are ovate oblong in shape and approximately two to seven inches in length, while the flowers, which have a distinct odor, are greenish in color. The fruit is a purple berry about one-centimeter and contain a single seed. The flavor of cinnamon is the result of an essential oil which makes up about 1/2% to 1% of its composition. This oil can be prepared by roughly pounding the bark, macerating it in seawater, and quickly distilling the whole. The oil is of a golden-yellow color, with the characteristic odor of cinnamon and a very hot aromatic taste.

Cinnamon has been known from ancient times, with the first mention of particular spice in the Old Testament being of cinnamon. In this, Moses commanded the use of sweet cinnamon and cassia in the holy anointing oil. Additionally, cinnamon is also mentioned elsewhere in the bible. This herb was so highly prized among ancient nations that it was often looked upon as a gift fit for even God. Cinnamon was imported to Egypt as early as 2000 B.C. The herb is also alluded to by Herodotus and other classical writers. Cinnamon was too expensive to be commonly used in funerals of ancient Rome. However, the Emperor Nero is said to have burned a year’s worth of the city’s supply at the funeral for his wife in 65 A.D.

Cinnamon can be harvested by growing the tree for two years and then coppicing it. About a dozen shoots will form from the roots in the next year. These shoots are then stripped of their bark and left to dry. Only the thin inner bark is used, while the outer woody portion is removed. Each dried strip of cinnamon are then cut into lengths of about five to ten centimeters for sale.

Cinnamon has been around for thousands of years. It is revered as a spice and also as a healing agent. Cinnamon was included in embalming oils by the Egyptians. This herb was used in China to treat fever, diarrhea, and menstrual problems dating as far back as 2000 BC. Cinnamon was a major trade commodity during the ancient times. Cinnamon grew in the southern regions of Asia originally. cinnamon tree This herb is used to help relieve upset stomachs, reduce milk flow, stop excessive menstrual flow, and alleviate back pain. Research has also determined that cinnamon contains components that possess antifungal and antibacterial capabilities. This herb is found in some toothpaste, which allows it to help some decay-causing bacteria. Cinnamon is also helpful for promoting healthy blood sugar levels.

The dried bark of the cinnamon plant is used to provide alterative, analgesic, antibacterial, antifungal, antiseptic, astringent, carminative, diaphoretic, emmenagogue, febrifuge, sedative, stimulant, and stomachic properties. Primarily, cinnamon is beneficial in treating abdominal pain, candida, diarrhea, gas, gastric disorders, and indigestion.

Additionally, this herb is also extremely helpful in dealing with arthritis, asthma, backaches, bloating, bronchitis, cholera, coronary problems, fevers, excessive menstruation, nausea, nephritis, parasites, psoriasis, rheumatism, upset stomach, vomiting, and warts. For more information on the many beneficial effects provided by cinnamon, please contact a representative from your local health food store with questions.

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Natural Sweeteners Vs. Artificial Sweeteners
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Date: April 30, 2009 10:16 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Natural Sweeteners Vs. Artificial Sweeteners

Artificial sweeteners are food additives intended to replace the sweetness of sugar without the calorie intake. There are also natural sweeteners that can replace sugar, so which should you choose? Natural sweeteners such as sugar, honey and grape juice are well known, although there are also the less well known, but much more effective, sucanat and stevia.

Sucanat is dried unrefined cane sugar, and unlike refined sugar retains the molasses. Stevia, on the other hand, is a shrub, native to Paraguay, the leaf of which contains a non-sucrose sweetener, 300 times the sweetness of sugar, and which is not absorbed by the body. It is a sweetener pure and simple, with no proven health issues. It is also Japan's most popular sugar substitute.

Artificial sweeteners have been known for many years, the first and best known being benzoic sulfanide, known to you as saccharin. The health risks of saccharin have been the subject of debate for over 100 years and have yet to be resolved. Studies had shown it to cause cancer in rats, and it was placed on a list of known or suspected carcinogens.

It has been banned for use in the USA, but that was lifted by the FDA in 1991, and in 2000 saccharin has no longer required a health warning label. The issue appears to have been resolved by rats metabolizing saccharin in a way not possible in humans. However, many are still suspicious of it, and if you don't trust a food additive then do not voluntarily consume it.

The top two artificial sweeteners in the USA are sucralose and aspartame. Sucralose, discovered in the UK in 1976, is the less emotive of the two, and is chemically the chlorocarbon trichlorogalactosucrose, produced by chlorination of sucrose and 600 times as sweet. It should be stressed that a chlorocarbon is totally different to a chlorinated hydrocarbon. It is generally considered safe to use, although it is very slow rate of degradation in waste water has raised concerns that concentrations could increase with increasing popularity of the sweetener.

According to' Sweet Deception', the book states sucralose to be discovered during the search for an insecticide, and is produced when sugar is treated with acetic anhydride, hydrogen chloride and trityl chloride among others in the presence of toluene, MIBK and dimethyl formamide among other solvents. Although marketed as coming from a natural source, it is anything but natural.

Aspartame was developed by G.D. Searle, and its approval by the FDA has been a matter of concern for many years. Promoted by Donald Rumsfeld, then CEO of Searle, he "called in his markers" to have the substance approved, which was not one of the more glorious moments in America's history.

It is used in over 6,000 products, most household names, yet was based on "inconclusive and incompetent science" according to detractors. In 1981, on the day of his inauguration, Ronald Regan suspended the powers of the FDA on aspartame, and then a month later appointed a new FDA head, Arthur Hayes, who immediately licensed the substance. Donald Rumsfeld was on President Regan's team.

There is a strong body of evidence that aspartame is toxic to humans, although the official evidence has discredit such studies. Recent evidence that linked aspartame to cancer has been stated as irrelevant to humans. In spite of the concerns, the substance has been approved, not only in the USA but also by the European Union. This might call into question the relevance of studies to humans, but many still believe that commercial considerations are behind these decisions.

In fact, an extensive study carried out by the Italian European Ramazzini Foundation, showed that aspartame can cause a significant increase in cancers and leukemias in rats at well below the doses allowed by the EU or the US. This substance required further study by bodies with no vested interest in the outcome.

Those that believe so point to the stevia situation. This natural sweetener is banned for use as a food additive in the EU, and cannot be sold as sweetener due to the FDA not recognizing it as such. It has also been banned in Hong Kong, even though it is the sweetener of choice in Japan, with no apparent side-effects becoming endemic in that country. The USA might not approve stevia as a sweetener, but it is considering lifting its ban on cyclamate.

Cyclamate was banned by the FDA due to tests on rats indicating a possibly carcinogenic effect, but no more positive than those on aspartame. Cyclamate is permitted in Canada, where saccharin is not, and also in the UK, but not throughout the EU.

It is obvious, then, looking at the various claims and counter-claims, and the conflicting legislation between civilized countries, that the artificial sweetener industry is wrought with uncertainty. In the past, it is almost certain that commercial considerations have come before the health of the nation, and that does not engender confidence.

In fact, the only sane approach to take at this time would be to avoid artificial sweeteners altogether, and stay natural. That is not to claim that natural products are safe to eat - far from it! Many of the most virulent poisons are natural, but the well-used natural sweeteners appear to be safer at this time than any of those artificially manufactured.

There might be objections to this where diabetes is concerned, and Canada, while banning saccharin for normal use, still allows it for use by diabetics. This is the one of the two major bodies that promotes the use of artificial sweeteners: the diabetic lobby and the weight loss lobby.

It is difficult to question the obesity and weight problem that America has while at the same time arguing against the use of artificial sweeteners. However, don't forget that stevia is widely used in Japan with no reported health problems, and stevia is a natural sweetener that is permitted for use as a food additive, and that is not absorbed by the body.

However, there is also a recent 2005 study that has indicated that diet drinks containing artificial sweeteners might fool your body into believing that the sweet taste is promising energy, and when it doesn't materialize, you feel hungry and eat more. This has been supported by animal studies.

These have shown convincingly that the sensation of sweetness induces the production of insulin with resulting hypoglycemia because there is no actual increase in blood sugar. This induces increased food intake. This has been proved with rats, and also proved was the fact that the natural response of eating less at the next meal, after sugary food, was gradually diminished in animals fed non-calorific sweeteners.

The choice is yours, but it would seem advisable to stick to natural sweeteners for the time being, at least until the studies carried out are in concurrence as opposed to offering conflicting results depending upon who is doing the testing.



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Multiple Vitamins
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Date: February 04, 2009 09:17 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Multiple Vitamins

It has been announced that it pays to take your vitamins, as the American Medical Association has completely reversed its previous anti-vitamin stance after twenty years and is now encouraging all adults to supplement daily with a multiple vitamin. After this decision, a review of 38 years of scientific evidence has convinced the Journal of the American Medical Association (JAMA) to rewrite its policy guidelines regarding the use of vitamin supplements.

It is common knowledge that today's diet is not providing sufficient nutritional value to keep chronic diseases at bay. Although nutrient intakes in North American are generally sufficient to avoid overt vitamin deficiencies, sub-clinical deficiencies are extremely common. Most vitamins and minerals come mainly from fruits and vegetables, causing us to need at least five daily servings of each. Studies have found that the number of servings of fresh fruits and vegetables is well below the recommended fiver servings per day, with the intake of dietary iron, folic acid, and calcium being significantly below recommended levels for adolescent girls.

Not many people know that cardiovascular disease is a problem that has been cultivated by modern society, with the first report on cardiovascular disease in America being published in 1912. At that time, the disease was so rare that it took years to find. In less than 100 years, the changes to our lifestyle, environment, and to the food we eat have made cardiovascular disease the number one killer in North America.

A groundbreaking report on July 13, 2000 tied the development of most cancers to lifestyle and the exposure to environmental and occupational risk factors. Although a genetic influence was not negated, as it appears to account for about 30% of total cancer risk, the findings placed the blame on poor dietary habits, smoking, alcohol consumption, lack of exercise, and exposure to environmental toxins. It has been recommended that a diet made up of plant-based foods which include vegetables, fruits, and grains is essential.

Stroke, the third-leading cause of death in the most developed countries for decades, occurs when blood flow to the brain is cut off due to a thrombotic event in one of the major arteries feeding the brain. A major cause of disability among adults and a principal factor in late-life dementia, small strokes can often go unnoticed. Because hypertension is the major cause of stroke, potassium and its blood pressure-lowering abilities are often helpful. Additionally, nutrients such as folic acid, bioflavonoids, polyphenols, and assorted antioxidants play an important role. The consumption of citrus fruit juices that contain high levels of vitamin C, and cruciferous vegetables like broccoli, cabbage, Brussels sprouts, bok choy, and cauliflower give protection against stroke.

Not only are we not eating enough of the proper food groups, the foods we do eat are often short in vital nutrients and high in calories. Nothing can replace the value of a diet that is carefully balanced. However, in today's high-stress world, we often face a absence of physical activity and a surplus of meals on the run, consisting of fast-food and processed foods that lack nutritional value. We should never neglect the importance of a well-balanced diet that is high in fruits and vegetables and we should make every opportunity to eat as close to the earth as possible.

Unfortunately, in today's fast-food world, it is hard to get away from the high-calorie, low-nutrition, over-processed, corporate food culture. If you value your health, it makes sense to take the extra step and start supplementing your diet with nutritional supplementation, as it is your personal health insurance to help you age gracefully. Stop into your local or internet health food store and look for a good multiple vitamin supplement to help boost your current diet.

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Noni Fruit Extract
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Date: November 22, 2008 09:34 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Noni Fruit Extract

Tahitian Noni juice can promote a healthy body in many ways. These Noni benefits are conferred by the phytochemicals contained within the fruit pulp, but before discussing the benefits of Noni let's first have a look at what it actually is.

Morinda citrifolia is also known as the Indian or beach mulberry tree, and is a member of Rubiaceae family. Although it originated in Southeast Asia, it has spread all the way to French Polynesia and the Dominican Republic. It is mainly cultivated in Tahiti for its fruit, known as cheese fruit or Noni fruit.

Although it is a staple food in some areas of the Pacific, it has a pungent smell and a bitter taste, and often eaten either raw or cooked only in times of famine. However, the fruit is particularly rich in phytonutrients, and many people swear by the Noni benefits it to maintain a glowing healthy body, free from disease and many of the health problems from which most people suffer.

The strange thing about it is the taste: you would not drink Tahitian Noni juice by choice, nor eat the fruit, so how were these Noni health benefits discovered? Hunger likely explains it: those forced to eat it through hunger were likely the lucky ones, who actually ate a nutritional diet even though they were eating a fruit normally eaten only in times of famine.

Among the conditions that Noni fruit is believed to protect you from are cardiovascular disease, high cholesterol levels, asthma, cholesterol, strokes, migraines, a weak immune system, arthritis and some cancers. Many of these conditions should give you a clue as to the nature of the phytochemicals contained within the fruit, since most of them involve free radical attack and immune system response.

Prior to examining thee diseases and conditions in detail, let's have a look at the chemicals the fruit has been established to contain. It is rich in dietary fiber, offering 100% of the Dietary Reference Intakes of the Institute of Medicine for each 100g serving, and also contains enough carbohydrate to meet 55% of you DTI needs. However, that is just the start.

The Noni pulp powder contains ten times the DRI of Vitamin C, and large quantities of Vitamin B3 niacin), potassium and iron. The Tahitian Noni juice itself contains few nutrients, and only the Vitamin C is retained to any useful level. It is therefore the pulp powder that offers the major nutritional benefit. In fact, because it has to be pasteurized at high temperature to meet regulations the for liquid product, Noni juice loses most of its nutritional content, and even the 31% Vitamin C content is surprising since that too is destroyed at high temperatures.

It is the high phytochemical content of Noni powder that renders it such an important supplement, and a scan down the following components will give you an idea of how the fruit got its reputation. The known Noni benefits are obtained from:

Lignans: these are phytoestrogens that have been reported to offer a reduced risk of ovarian and breast cancers, osteoporosis and also cardiovascular disease. They possess antioxidant properties and although reports as to their effectiveness are varied, they appear to have beneficial health effects.

Flavanoids: These are phenolics, including asperulodisic acid and rutin. The former is believed to be effective against certain cancers, while rutin, also contained in buckwheat, is a strong antioxidant that strengthens capillaries, and also helps to prevent atherosclerosis and heart disease.

Catechin and epicatechin: strong antioxidants that help prevent heart disease, strokes, diabetes and cancers. It also protects your skin against the harmful effects of the ultra-violet component of the sun's rays. Catechin is a form of flavanoid, and one of the more powerful of the antioxidants needed to destroy the free radicals that would otherwise ravage your body through the destruction of your body cells.

B-Sitosterol: a plant sterol that is believed to reduce the cholesterol in your blood, but still requires scientific proof, even though there is plenty of evidence to support its effect. Plant sterols are the basis of the cholesterol-lowering yoghurt drinks that you can but in your local supermarket.

This list is not exclusive, and there are several other phytochemicals found in Noni pulp powder that are believed to confer significant health benefits, but that are still seeking scientific support. The fact that such support has yet to be provided is not a reason to doubt their effectiveness, although the above benefits are sufficient to justify the reputation of this nutritional supplement that few have heard about.

There have been only around 110 reports on Noni research since the 1950s, so it is not surprising that the scientific proof is weak, although of these around 100 have appeared since the year 2000. Don't forget that there was no proof for the effectiveness of penicillin until it was discovered!

Even the biochemistry of the components of Tahitian Noni juice, such as the polysaccharides not mentioned in the above list, is in the early stages of research, and an increasing number of traditional remedies are being found to have a valid scientific and medical basis. These polysaccharides are a form of dietary fiber with probiotic properties that can be fermented by bacteria in the gut to form short chain fatty acids that possess many beneficial health properties.

Take the heterocyclic iridoids, for example. These are unknown to most people, yet they are found in many plants that have extensive medicinal properties, and might be responsible for many of them. They appear to possess anti-inflammatory, antiviral and antispasmodic properties, and support the cardiovascular system, the immune system and help to maintain a healthy blood sugar level. These are also contained in Noni pulp powder.

Another component of Noni fruit that most people have not heard of is damnacanthal. This inhibits certain tyrosine kinesis that basically have a controlling effect on the division of body cells. They particularly inhibit the Ras genes, responsible for some cancers due to uncontrolled cell division. Damnacanthal can prevent Ras genes from causing these cancers.

There are many more benefits that Tahitian Noni juice, or particularly the powdered Noni pulp, can confer, and it is recommended that it be taken as a supplement by anybody needing a general health tonic since it possesses such a wide variety of beneficial properties. The Noni benefits which those that use it enjoy area available to everyone, even though it is one of the lesser known of the beneficial health supplements.



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Lutein 20mg (FloraGlo)
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Date: September 26, 2008 03:49 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Lutein 20mg (FloraGlo)

Maintains Healthy Visual Function*

It has been well established that lutein is present in high concentrations in the retinal tissue of the human eye. However, a study was conducted in human volunteers to determine whether taking lutein in supplement form actually increased the density of the carotenoid pigments present in the macula. In this study of eight individuals, researchers estimated the density of the macular pigments prior to having each individual take 10 mg of lutein daily in supplement form for 12 weeks. Plasma lutein concentrations were measured at 4-week intervals. During the first four weeks of the study, plasma levels increased five-fold from pre-supplement measures, and then remained at this level for the duration of the study. It was also shown that, due to increased deposition of lutein in optical tissues, macular pigment density increased by an average of 5.3% at the 4-week mark, and continued to increase until the duration of the study.1

A study was also conducted to investigate the possible role of specific nutrients in protecting the lens of the eye against aging, a risk factor for compromised visual function. The study was comprised of 376 individuals aged from 18 to 75. Of the nutrients measured, it was found that the lenses of individuals with higher concentrations of lutein and zeaxanthin showed less of an effect from the aging process. The investigators concluded that these carotenoids might play a protective role in supporting the maintenance of healthy vision.2

The Age-Related Eye Disease Study (AREDS) was a landmark study of the effects of diet and antioxidant supplementation on eye health. The study enrolled over 3500 subjects aged 55 to 80 years who were followed for approximately 6 years. Among the data collected in this multi-faceted study was a self-administered Food Frequency Questionnaire (FFQ). The AREDS Report No. 22 examined the data from the FFQs and determined that, of the nutrients evaluated, only lutein and zeaxanthin were directly related to maintaining eye health with statistical significance3. These findings corroborated similar results of an earlier multi-center study published in the Journal of the American Medical Association that also found that those with a higher intake of lutein and zeaxanthin maintained healthier eye function.4 These promising results have spurred the design of a second major clinical trial (AREDS2), which is currently enrolling participants to study the impact of supplemental xanthophylls (FloraGLO® Lutein and zeaxanthin) and other nutrients on age-related eye health.5

In addition, a double-blind placebo controlled trial was performed in ninety individuals who had signs of compromised visual function. Individuals were divided into three groups and received either 10 mg FloraGLO® lutein, 10 mg FloraGLO® lutein plus a multivitamin/multimineral formulation, or placebo for 12 months. In both the FloraGLO® lutein and FloraGLO® lutein plus other nutrients groups, improvements were seen in mean eye macular pigment optical density, visual acuity and contrast sensitivity. No improvements were noted in the placebo group.6 These results demonstrate FloraGLO® lutein’s beneficial effect on maintaining healthy visual function.

Newly published research has demonstrated that lutein and zeaxanthin supplementation may enhance visual performance under glare conditions. Forty healthy subjects took daily doses of 10 mg FloraGLO® Lutein plus 2 mg zeaxanthin for six months. They were evaluated for changes in macular pigment, glare disability and photostress recovery at the onset of the study, and at 1, 2, 4 and six months. After six months, subjects experienced an average increase in macular pigment optical density (MPOD) of 39% compared to baseline, and all but two participants experienced some increase in MPOD. This increase in MPOD was also directly related to measured improvements in visual performance after exposure to bright light, as well as photostress recovery.7 This study suggests another way in which lutein and zeaxanthin can help support optimal visual function in healthy individuals.

Potent Antioxidant Protection*

Most of the beneficial effects of lutein are ascribed to its potent free radical scavenging abilities. It is well-known that lutein is a carotenoid related to beta-carotene and possesses antioxidant activity against a number of reactive oxygen species.8

More direct evidence for the free radical scavenging activity of lutein is found in studies of its effects on human lens epithelial cells. Cell cultures were exposed to ultraviolet light after pretreatment with lutein or alpha-tocopherol. Both nutrients were found to reduce ultraviolet-induced damage to lens epithelial cells. However, lutein was shown to have significantly higher photoprotective activity than alpha-tocopherol9 demonstrating its potential as a high-powered antioxidant.

A further review of the mechanisms of lutein in conferring a protective role reveals evidence for its antioxidant activity in various body tissues. Lutein has been shown to be an effective antioxidant in vitro as well as in experimental models of a number of body systems.10

Supports Healthy Skin*

A recent randomized, double blind, placebo-controlled study has demonstrated the positive effects of oral and topical administration of lutein on skin health parameters (surface lipids, hydration, photoprotective activity, skin elasticity and skin lipid peroxidation). Forty female subjects were divided into four treatment groups. Treatment options included oral administration of 5 mg of FloraGLO® Lutein twice daily or placebo and topical administration of 50 ppm FloraGLO® Lutein twice daily or placebo. Each treatment group received either an active oral treatment with a placebo topical treatment, a placebo oral treatment with an active topical treatment, both active treatments, or both placebo treatments. Statistically significant improvements were seen in all five parameters tested in all treatment groups compared to the group receiving only placebos. The greatest overall improvements were seen in the group receiving both active oral and topical treatments, while lesser but still significant improvement was seen in both the active oral only and the active topical only groups. Additionally, oral administration of lutein conferred superior photoprotective activity (as measured by skin surface redness after exposure to ultraviolet light) and prevention of lipid peroxidation (as indicated by levels of malondialdehyde in skin lipids after exposure to ultraviolet light) than either topical lutein or placebo.11

Diverse Cinical Benefits*

Evidence from various experimental trials suggests that lutein may play a protective role on the circulatory and cardiovascular systems. Its antioxidant activity may also extend to the heart, skin, lungs and blood vessels, making it a nutrient with diverse clinical benefits. Lutein possesses the ability to promote the health of many body tissues.12

Suggested Adult Use: One softgel daily with food, or as directed by a health care professional.

Does Not Contain: milk, egg, wheat, sugar, sweeteners, starch, salt, or preservatives.

Scientific References

1. Berendschot TT, et al. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Invest Opthalmol Vis Sci. 2000 Oct; 41(11): 3322-6.

2. Berendschot TT, et al. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Arch Opthalmol. 2002 Dec; 120(12): 1732-7.

3. Age-Related Eye Disease Study Research Group. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol. 2007 Sep; 125(9): 1225-32.

4. Seddon JM, et al. Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration. JAMA. 1994 Nov; 272(18):1413-1420.

5. www.nei.nih.gov/neitrials/viewStudyWeb.aspx?id=120. Clinical Studies Database. Age-Related Eye Disease Study 2 (AREDS2). Last Updated 2/28/2008. Viewed 5/15/2008.

6. Richer S, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr; 75(4): 216-230.

7. Stringham JM and Hammond BR. Macular pigment and visual performance under glare conditions. Optom Vis Sci. 2008 Feb; 85(2):82-8.

8. “Lutein and Zeaxanthin”. PDR Health. www.gettingwell.com/drug_info/nmdrugprofiles/nutsupdrugs/lut_0164.shtml

9. Chitchumroonchokchai C, et al. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. J Nutr. 2004 Dec; 134(12): 3225-32.

10. Krinsky NI. Possible biologic mechanisms for a protective role of xanthophylls. J Nutr. 2002; 132: 540S-542S.

11. Palombo P, et al. Beneficial Long-Term Effects of Combined Oral/Topical Antioxidant Treatment with the Carotenoids Lutein and Zeaxanthin on Human Skin: A Double-Blind, Placebo-Controlled Study. Skin Pharmacol Physiol. 2007; 20: 199-210.

12. Mares-Perlman JA, et al. The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview. J Nutr. 2002; 132: 518S-524S.





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Don’t Live With Pain, Live Pain Free – Curamin Is The Answer
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Date: April 24, 2008 04:32 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Don’t Live With Pain, Live Pain Free – Curamin Is The Answer

Fact, more than 50 million Americans suffer from chronic pain. Chronic, meaning pain that continues daily, weekly, monthly, and yearly, pain may which never end with out help. According to the Journal of the American Medical Association, pain is the primary reason people seek the advice of a doctor or health practitioner, and the number one reason people take alternative medicine.

A new revolutionary dietary supplement for pain and inflammation is now available on the market. Introduced by Terry Lemerond, this new formula called Curamin has changed thousands of lives. This formula contains three anti-inflammatory herbs and one amino acid that can help one live a more normal pain free life.

The first ingredient: Curcumin is a substance found in turmeric. Curcumin contains curcuminoids which have been shown to reduce inflammation and pain. Turmeric is an ayurvedic herb discovered in India and brought over to the United States has demonstrated amazing results. Turmeric has been cooked with and used as a medicine for over 2000 years. The active ingredient in turmeric is curcumin which has demonstrated six important properties. Curcumin has anti-inflammatory, antioxidant, antiviral, antibacterial, antifungal, and anti-cancer properties. As you can see this herb has made quite a name for its self.

The second ingredient is Boswellia. Boswellia contains boswellic acid which is the active ingredient in this herb as well. This herb has also demonstrated its natural ability to fight inflammation and more. Research suggests that Boswellia’s active ingredient can actually modulate the expression of the genes involved in the body’s inflammation response thus giving itself an anti-inflammatory name.

The third ingredient is DLPA an amino acid also known as DL Phenylalanine. This amino acid can help the body product more serotonin in the brain. D-phenylalanine can actually help reduce chronic pain through the production of serotonin. Serotonin helps one feel more relaxed and level headed this is something everybody needs when it comes to pain that drives them crazy all day long. Those people consuming MAO inhibitors and anti-depressants need to avoid DLPA with out a doctor’s supervision.

The forth and last ingredient in Curamin is nattokinase. Nattokinase is an extract from fermented soy cheese. For thousands of years natto has been consumed by the Japanese people with out even know the health benefits of its consumption. Nattokinase can help the body fight blood clots, thin the blood, and fight pain and swelling.

This new formula Curamin has the three top herbs that fight inflammation in the body, when combined with DLPA, this product has the amazing ability to fight pain by attacking the source of pain, inflammation.

Recommended doses for curamin are 2 capsules in the morning and 2 more capsules in the evening after work. Some may need a stronger dose at first, this is where one should take 4 capsules at one time in the morning for the first few days then step back to 2 in the morning and 2 in the evening.

We have free samples available upon request and back the curamin product with a 100% satisfaction guaranteed. So if you are un-satisfied, just return the unused portion of the product for a full refund of the purchase price minus shipping costs.

So what are you waiting for? Are you ready to live pain free? Give curamin a try!

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Celiac disease
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Date: April 08, 2008 11:58 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Celiac disease

Celiac disease also known as sprue, is an autoimmune disorder that often goes un-detection. It mimics the symptoms of other conditions including: irritable bowel syndrome, gastric ulcers, Crohn’s Disease, diverticulitis, parasitic infections, skin disorders, iron-deficiency anemia caused by menstrual blood loss, and various nervous system conditions. All of which are very uncomfortable for anyone to experience.

To complicate matters, between fifty to sixty percent of celiac patients have no obvious symptoms, which makes this disease particularly difficult to diagnose. This has led to the assumption that the disease was uncommon in the United States. However, recent estimates suggest that one in one hundred and thirty three people have the disease. Do you know if you have it?

In the Year 2000, a paper published in the Journal of the American Medical Association reported that the incidence of Celiac disease among 1200 children and adolescents tested for the disorder ranged from one in fifty seven to one in thirty three. Symptoms in children differ somewhat from those of adults in that fatigue, irritability and behavior changes are more common in children with Celiac disease. Infants with Celiac disease may lose weight and "fail to thrive."

Older children may have delayed growth or unexplained anemia due to malabsorption. Like adults, Celiac disease children have abdominal gas, pain and foul smelling stools. Liquid Supplements are recommended for individuals with Celiac's Disease.

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Urinary Incontinence and Overactive Bladder: The Silent Conditions
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Date: February 07, 2008 05:56 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Urinary Incontinence and Overactive Bladder: The Silent Conditions

Even though we are all comfortable talking about cardiovascular issues, mind and brain function, and digestive wellness, the topic of bladder health is rarely discussed. Whether it is vaguely touched upon or completely ignored, bladder issues including urinary incontinence and overactive bladder get a low amount of coverage considering their prevalence throughout the world. Research has shown that 17 million Americans can be diagnosed with urinary incontinence and 33 million Americans suffer from overactive bladder. So with these figures, why is it that we rarely hear about these issues? Firstly, urinary incontinence and overactive bladder have been marked as taboo topics, as sufferers are not eager to openly talk about their experiences since they can be uncomfortable and embarrassing to discuss. Due to the social stigma that is associated with urinary incontinence, it is extremely under-diagnosed and under-reported. Another reason why people aren’t talking about bladder issues is because the market has only recently become recognized as financially viable as the market for urinary incontinence treatment reached more than $7 billion by the end of 2006, as compared to $276 million in 2000. With the new baby boomer population turning 60 in a few years, it is anticipated that urinary incontinence and overactive bladder treatment will soar much higher.

No matter the reason, these are serious health issues that affect people deeply. Both physiological and psychological aspects take their toll on a person. Studies have shown that people with these illnesses have a poorer quality of life, causing sufferers to become reclusive and isolated as they are too embarrassed to talk about their bladder issues.

However, there are a variety of ways that bladder health can be addressed, including pharmaceutical, behavioral, and natural approaches. Various drug therapies have been found to improve bladder control. However, most drug therapies also have unpleasant side effects such as dry mouth, dry eyes, blurred vision, and memory loss. Some drugs can even produce harmful long-term side effects. National continence groups also have recommendations as to behavioral interventions and exercises that can be taken to deal with bladder issues. Bladder control training, which involves teaching the bladder to completely fill and empty, is important to adequate fluids and avoid going to the toilet just in case. Kegal exercises can also be done to help strengthen the muscles that contract if you are urinating.

There are also natural herbal and nutrient options that are worth considering. These include Horsetail and Crateva nurvala, which both are means of improving bladder tone and control. Horsetail, which is high in silica, is known as a urinary astringent and antispasmodic. It relieves involuntary muscle spasms. Crateva has been shown to improve bladder tone and total bladder capacity. It improves urine flow, which helps the bladder to empty completely.

Since bladder health is a concern for many Americans, as it impacts what we do, where we go, our confidence levels, and sense of freedom, we need to start openly discussing bladder health and become more informed about the options that are available to us. Even though sufferers have learned to live with poor bladder health, recent research is making natural dietary ingredients an alternative for those who are looking for support to their bladder health.

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Exotic Herbs From The Amazon Basin
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Date: June 22, 2007 05:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Exotic Herbs From The Amazon Basin

Although many traditional herbal medicines have yet to find complete scientific corroboration in the West, it follows logically that people wouldn't use an herbal product for centuries if it didn't work.

Many of the popular herbs we all recognize as having great health benefits were only recently considered pretty exotic. Even green tea - a staple in China for centuries -has only lately gone main stream.

So it will likely be with herbs from the Amazon basin and its environs. The Amazon basin is one of the most bountiful environments on the planet. Explorers and botanists from the West have looked to this region for generations for the "next big thing." Of course, in many cases, the "next big thing" has already been in use for centuries.

In this issue of Ask the Medicine Hunter, we're going to look at some energizing and life- stimulating herbs that also happen to have great antioxidant properties, too. Best yet, many of them are available to us here from companies that practice fair trade policies.

Let's take a look at some of the herbal powerhouses coming out of the Amazon (and its nearby neighborhoods):

Maca (Lepidium meyenii) has been cultivated for a long time at least 2000 years. Related to brassica family plants like radishes, mustard and cabbage, its foliage does actually look somewhat radish-like, but grows close to the ground.

Maca is cultivated by the Andean people in Peru's central highlands, and contains a plethora of beneficial compounds that enhance overall health and vitality. The tradition of cultivating maca is an old one some strains have been found in Incan sites that date from 1600 B.C. During early European colonization, maca was used by the local native culture as a form of currency, much of the way cocoa was used by the Aztecs, further north in pre-Columbian Mexico.

Maca thrives in high altitudes - between 10,000 and 16,000 feet. The harsher the conditions, the better it grows, or so it seems. In fact, efforts to grow the plant in Central Europe haven't been as successful - maca seems to enjoy its home turf the best. In Peru, maca is a popular and beloved nutrient-packed superfood, and is commonly powdered and mixed into drinks at roadside stands throughout the Andes.

Q. I've heard of maca being used for healthy libido - are there any other benefits?

A. Maca is a natural energizer, and although it is recognized for it's libido enhancing abilities, it has other uses, too, acting as an adaptogen - similar to rhodiola or ginseng. In fact, in South America, maca is known as "Peruvian Ginseng." Though maca is not ginseng at all, some of the benefits of both plants are similar.

In any event, maca is recommended for boosting the immune system, menopause support, and hormonal balance in general. For daily use, maca is most recognized as a great source of energy and all-day endurance. Alkaloids from maca root may be partially responsible for both maca's energizing and libido boost. Research shows that maca affects the hypothalamic-pituitary (HPA) axis - boosting energy and overall aphrodisiac prowess in men and women. Maca contains novel compounds called macamides and macaenes, which have been proven in animal studies to significantly enhance energy, stamina and sexual function reasons people have been so consuming maca for 2000 years.

There are other serious reasons why maca is such an excellent plant. One group of compounds in maca is the isothiocyanates-aromatics constituents that are responsible for the "hotness" of mustards and radishes - fellow members of the brassica family. Isothiocyanates from other members of the brassica family may reduce the risk of breast and stomach cancer. Although the same constituents specifically from maca haven't beentested, it's plausible that they could have the same effects.

Q. I've heard a little about guarana extracts - is it just caffeine?

A. Guarana is widely loved for its mild stimulating effect, which is due to caffeine. But this is by no means this Amazonian herb's sole beneficial compound. Guarana (Paullinia cupana) is so logically ingrained in the culture of Brazil that it's practically a rival (actually out-sells) Coca-Cola in its soft-drink form. Like many other indigenous herbs, guarana was in use locally well before European settlement. Its Latin name comes fromthe German botanist C.F. Paullini, who first encountered the herb in the 1700s. This evergreen vine typically climbs fairly far up the Brazilian forest trees. The seed is the part that gets used. In one clinical study, guarana boosted the memory alertness of participants, even when the caffeine level per dose was a low 9 mg., as compared with approximately 100 mg for a cup of coffee. This effect suggests that other agents than caffeine contribute to a feeling of well being.

Guarana also contains powerful antioxidants including catechin, epicatechin and proanthocyanidins, which protect cells against destruction from free radicals, and impart benefits to the body's tissues and blood. The small seed of this plant is powerful in its health benefits.

Catuaba Bark:

Catuaba (Erythroxylum catuaba) is a common tree found in South America from Brazil to Peru, in the same genus as the coca plant. Catuaba contains components known as alkaloids. These alkaloids (called catuabine A, B, and C) are probably responsible for themental boost most people get when they take catuabe-based supplements or mixes.

There may be little confusion regarding catuaba, because various species and genus typesuse the common name. As a result, "catuaba" gets bandied around a lot, and one person'scatuaba may not be the next. Read labels carefully. The catuaba I've had the best luck with is Erythroxylum catuaba.

Coffee Fruit:

One of my favorite drinks in the world is coffee, and I'm sure at many people reading thisconsider it the essential part of their morning, too.

The part of coffee that we use the most is the seed of the coffee fruit - which appears as a bright, red berry. Most of the time, this fruit is sloughed off and left behind in the process of making coffee - it's really too delicate to last long in hot conditions.

But advances in technology have tapped a previously discarded resource. Though the fruit of coffee is available in any coffee-growing economy, a high antioxidant commercial extract of "coffee cherry" is now available from the fruits of coffee plants in Mexico.

Coffee fruit has many of the attributes of other dark-colored, anthcyanin-rich fruits. Coffee fruit (also referred to as "coffee cherry") appears not to be just another antioxidant, however. Current research on this once-forgotten, former castoff shows impressive abilities to decrease tumor size, and possibly even prevent their formation in the first place. It seems that the elements in coffee berry activate T-lymphocytes in such a way that mammary tumors are shrunk or simply put on hold. It will be fascinating to see how this science plays out.

Muira Puama Bark:

Muira puama (Ptychopetalum olacoides) grows between 15 to 45 feet high. Native to theAmazon basin of Brazil, the dried bark has been used for centuries as a traditional energysupport. Components include beta-sitosterol, campesterol and lupeol.

Muira puama, like other central nervous stimulants has been researched lately for its ability to boost memory retrieval and protect neural (brain) tissue. Who knows? Maybe this traditional ingredient could someday be on the cutting edge of natural medicines fighting Alzheimer's, much the way green tea and turmeric are currently. In one unpublished French study of 262 men with low libido and poor erectile function, 62% experienced significant improvement after taking an extract of Muira puama for two weeks.

Acai Berry:

Acai (Euterpe acai) berry is a traditional favorite (and readily available) food source for people in the Amazon. The tree is a tall-growing palm with berries that provide - a rich source of anthocyanins, potent purple pigments with extraordinary high antioxidant activity.

Once harvested, acai fruits decay rapidly. As with coffee fruits, special processing is the surest way to make certain the nutrients of acai berry make it to those of us outside the Amazon basin.

However, these wonderful fruits not only fight against free radical damage, but help our natural digestive enzymes and boost natural immune defenses, too. In fact, current research is investigating whether compounds in acai may have a fighting effect on leukemia, too. So far, the results have been very positive.

Look for supplements made using organically-grown, fair trade acai berry. The best companies ensure that the local people harvesting acai and the communities where they live gather more than just short-term benefits. The best companies work not just to provide jobs, but better lives for generations to come.

Q. What is sustainability and fair trade, anyway?

A. Sustainability refers to a set of naturally occurring circumstances, or intentionally designed practices and principles, which ensure that all parts or members of a situation are adequately nourished to promote their healthy continuance. In current parlance, sustainability often refers to practices and programs designed and implemented to keep natural systems healthy and flourishing. Many such programs focus on environmental protection and preservation of traditional cultures. In the world of medicinal plants, sustainable practices include organic agriculture, species management, fair trade, and benefit-sharing programs.

In other words, sustainability pays people fair wages, puts resources back into their communities, and ensures that the resources that benefit us all are going to be around for a long time. It is an earth-friendly, people-friendly concept of commerce that happily, is taking root around the world.

Conclusion:

The traditional cultures that use - and have used - these ingredients for generations wouldn't have done so if they hadn't been effective. Fortunately we live in an era when formerly locally-used herbs are now available far beyond their previous range. We are also fortunate to have companies and individuals working hard to make sure that the people who tend and care for these precious resources are paid fairly for their efforts, andthat their families and communities benefit from this commerce as well.

The great thing about using traditional herbs and ingredients that have been gathered in this manner is that you know they'll be around for a long time.



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Vitamin D Shows Promise For Cancer Prevention…
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Date: June 19, 2007 02:17 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Vitamin D Shows Promise For Cancer Prevention…

Vitamin D Shows Promise For Cancer Prevention…Researchers from the Creighton University School of Medicine, Nebraska, studied 1,179 healthy, postmenopausal women over four years to determine the benefits of vitamin D3 for cancer prevention. The women, from rural Nebraska, supplemented their diet with randomly assigned daily dosages of 1,400 mg – 1,500 mg supplemental calcium; 1,400 – 1,500 milligrams supplement calcium plus 1,100 IU of vitamin D3, or placebo. The women were 55 years or older and free from known cancers for at least 10 years prior to entering the study. Over the four-year trial, women in the calcium with vitamin D3 group experienced a 60 percent decrease in cancer risk compared to the placebo group. Researchers also found a 77 percent cancer risk reduction with the calcium with vitamin D3 group in the last three years of the study. Further studies are needed to see if the results apply to other populations. (American Journal of Clinical Nutrition, June 8, 2007, volume 85, issue 6, pages 1586-1591)



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EpiCore Benefits
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Date: April 09, 2007 05:02 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: EpiCore Benefits

Benefits

EpiCor® is a unique and novel dietary supplement used for support of immune health, with a fascinating history of discovery. In 1943, a company in Cedar Rapids, Iowa called Diamond V Mills, Inc. began manufacturing and selling a fermentation product from the yeast Saccharomyces cerevisiae, the same yeast used in bread and beer making. The product was and still is used as an additive for animal feed to help improve digestion as well as overall health in animals. It has been on the market for over 60 years.

Interestingly, when the company became self-insured, they became aware of unusually low rates of illness in employees that worked in the manufacturing plant for this animal product. This led to very low increases in their insurance premiums over the years compared to other companies, saving them quite a lot of money. Hence they began to investigate what might be the cause of the “healthfulness” of the employees at the fermentation plant. This investigation and subsequent research studies led to the formation of a new company called Embria Health Sciences, which now produces EpiCor® as a supplement for humans to support immune system health.1 Doctor’s Best® is proud to now offer the benefits of EpiCor® to its customers.

Beneficial Support of the Immune System and Activation of Natural Killer (NK) Cells in vitro*

A comparison study was performed on blood from 10 fermentation plant workers compared to that from 10 age and gender matched controls. The fermentation plant workers had several immune cell parameters that appeared superior to the control group. These included decreased levels of CD8 cells resulting in significantly increased CD4 to CD8 ratios, significantly improved cytotoxic natural killer (NK) cell activity even though total NK cells were decreased in number, higher killing efficiency of NK cells, significantly increased levels of secretory IgA, increased numbers of EpiCor™ specific antibodies, higher levels of red blood cell intracellular glutathione, and significantly lower levels of immune complexes. These results represent benefits on various cellular players of both the specific and innate parts of the immune system.1,3,4

NK cells are one of the first lines of defense used by the immune system. An in vitro study performed on human cells showed that NK cells were activated after incubation with EpiCor®, as evaluated by expression of the CD69 activation marker. The CD25 marker (IL-2 receptor) was also induced in the NK cells, although to a lesser degree.1,2 B cell activation was also noted through increased expression of CD80 and CD86 markers.2 Immediate increases in calcium levels were evident in peripheral blood mononuclear cells after exposure to EpiCor®, suggesting increased activation through calcium regulation.2

High Metabolite Immunogen*: Nutrient Make-up

Production of EpiCor® utilizes the common and harmless bakers or brewers yeast Saccharomyces cerevisiae in a patented process called MetaGen4™, a multi-stage fermentation and drying process. It differs from other yeast products in that it contains both the yeast itself as well as the metabolites or “nutrilites” formed by the fermentation process, which are present in the media.1 Together the media containing the metabolites and the yeast are dried to form EpiCor®. Analysis of EpiCor® reveals that it contains a mixture of natural polyphenols, phytosterols, beta-glucans, mannan oligosaccharides, fiber, trace amounts of B vitamins and minerals, as well as a host of other nutritional compounds.1,2

Beneficial Antioxidant Activity*

EpiCor® was tested for antioxidant activity in an in vitro assay called the Oxygen Radical Absorbance Capacity assay (ORAC). In this assay, EpiCor® was shown to have a total ORAC antioxidant level of 610 micromol TE (tocopherol (vitamin E) equivalents) units (ORAC units) per gram dry weight, which soared above other high antioxidant level foods such as cranberries (93 ORAC units per gram dry weight) and blueberries (62 ORAC units per gram dry weight).1,3,5

In another study, freshly isolated human neutrophils were treated with EpiCor® followed by the free radical generator hydrogen peroxide. Cells were treated with a dye that fluoresces when attacked by free radicals. Those cells treated with EpiCor® showed decreased fluorescence intensity compared to control cells not treated with EpiCor®, verifying antioxidant activity in vitro.2

Safety

Numerous safety tests have been conducted on EpiCor®, revealing an extremely safe profile. Animal studies performed by a leading toxicology laboratory showed no indication of any toxic effects of EpiCor®. An acute oral toxicity study on 20 rats showed that the product was safe when given to rats at a single oral dose of 2000 milligrams per kilogram of body weight (equivalent to a human ingesting 280 capsules at once). After 2 weeks the rats showed no clinical symptoms, no deaths, no abnormalities in body weight, and no gross pathological changes. The same safety results were found in a subchronic toxicity study where rats were given up to 1500 milligrams daily for 90 days (equivalent to a human ingesting up to 210 capsules daily for 1.5 years). Again, absolutely no signs or symptoms of toxicity were noted in these animals.1,3

In addition, a standard bacterial reverse mutagenicity test (AMES test) as well as a mammalian cell mutation assay using mouse lymphoma cells revealed no evidence of any increase in mutation rates after exposure to EpiCor®. EpiCor® also showed no evidence of mitogenicity (inducing increased cell division) in a human lymphocyte proliferation assay. This suggests that EpiCor® does not cause over-reactivity of cells1,3.

The effect of EpiCor® on specific liver enzymes CYP1A2 and CYP3A4 (enzymes involved in metabolizing certain drugs and other compounds) was assessed. Immortalized hepatocytes (liver cells) were treated with various concentrations of EpiCor® and compared to both positive and negative controls. EpiCor® did not increase the expression or activity of the liver enzymes, suggesting that it may not affect the metabolism of other substances or medications metabolized by these enzymes if they are taken simultaneously. It also did not appear to be toxic to the cells as measured by lactate dehydrogenase assays and microscopic analysis.1

Lastly, EpiCor® was tested for safety in humans in an open label study on 15 adult men and women given a single 500 milligram dose for 30 days. On various days throughout the study vital signs were monitored, and blood and urine samples were analyzed. No clinically relevant abnormal effects on the participants were found1.

 

EpiCor® also currently has received self-affirmed Generally Regarded as Safe (GRAS) status by an expert panel that included eminent toxicologists1.

 

EpiCor® is a novel compound with an incredibly unique composition that has been shown to enhance immune system function.*

Suggested Adult Use: Take one capsule daily with or without food.

 

 

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

Scientific References

1. Embria Health Sciences

2. Hart et al. A new Saccharomyces cerevisiae based product has anti-inflammatory effects while specifically activating human NK and B lymphocyte subsets. Unpublished study, personal communication.

3. Schauss AG, Jensen G, Vojdani A, Financsek I. After decades of ingestion by farm animals, the discovery of a yeast fermentate with unexpected significant immune modulatory activity when consumed by humans. [abstract] Journal of the American College of Nutrition, 2006; 25(5): 465.

4. Schauss AG, Vodjani A. Discovery of an edible fermentation product with unusual immune enhancing properties in humans. [abstract] FASEB J, 2006; 20(4):A143.

5. Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem 2004 Jun 16;52(12):4026-3



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Revita
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Date: March 08, 2007 12:27 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Revita

Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product.

Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class.

To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules.

Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth.

Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available.

Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects.

In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls."

In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded:

• The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls.

• 78.9% of subjects showed an increased mean value of hair diameter.

• "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness."

Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth phase) and telogen (resting phase) of the hair follicle. When the anagen phase is prolonged, and the telogen phase is shortened, increased hair growth results.

Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings:

• Total Number of Hairs: Significantly Increased

• Total Number of Terminal Hairs: Significantly Greater

• Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher

• Hair Follicle Activation: Intensive

In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials.

Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue remodeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss.

Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area.

The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp.

Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles.

Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E.

Spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth.

Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing.

Ketoconazole - Topical ketoconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that ketoconazole exhibits other methods to its anti-hair-loss effect. One such theory of ketoconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, ketoconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial.

If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% ketoconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.

Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with ketoconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen phase increased by 6.4% and 8.4% respectively during the study.

The results are similar to a previous study done on 2% prescription strength Ketokonazole where it was shown that use of 2% ketoconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion.

After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier.

Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss.

MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM.

The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes.

MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications.

Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness.

The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone.

According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss.

The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study.

Carnitine Tartrate - L-Carnitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate.

Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate.

The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased.

Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft.

Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids.

Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth.

L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications.

The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth.

Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day.

In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing.

Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic.

Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth.

Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle.

Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss.

After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week.

This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.

Q. Is Revita safe ?

A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as Ketoconazole have been tested in clinical studies and have been shown safe.

Q: Can I use hair sprays, mousses, gels, etc.?

A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita.

Q: Can I have my hair colored or permed while using Revita ?

A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita.

Q: What is SLS/SLES free ?

A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health.

Q: Can I blow dry my hair after using Revita ?

A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita.

Q: Who is a candidate for Revita ?

A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately.

Q: What type of results should I expect with Revita ?

A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment.

Q. Does Revita have any systemic side effects ?

A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically.

Q. Does Revita work for women?

A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair.

Q. I am using other topical treatments. Can I use Revita at the same time ?

A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair.

Q. Do I need to use Revita for a long time ?

A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp.

Q: Is stress a factor in hair loss?

A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.

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Betaine HCI and Pepsin
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Date: January 28, 2007 08:41 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Betaine HCI and Pepsin

Betaine HCI and Pepsin

Betaine HCl is a form of HCl used as a nutrient to supplement the stomach’s own production of HCl, or stomach acid. While occasional indigestion may be a result of acid irritating tissue in the structure above the stomach known as the esophagus, a line of research suggests that the cause of this irritation may actually be less than optimal stomach acid production. Stomach acid is normally produced by the parietal cells of the stomach and the function of stomach acid is to break down food that enters the stomach into smaller fragments and nutrient components. These components move through the stomach into the small intestine where they are further broken down by digestive enzymes in the upper part of the small intestine. The individual nutrients that result from the digestion of proteins, fats and carbohydrates can then be absorbed and assimilated by the body and used for metabolism and growth. However, optimal stomach acid production is certainly a major step for the efficiency of the digestive process. Less than ideal stomach acid production prevents foods from being broken down properly and places an added burden on the remainder of the digestive process, including enzyme production from the pancreas.

As mentioned earlier, the presence of optimal stomach acid is necessary for the digestion and absorption of critical nutrients. Amino acids and other peptides from proteins, minerals, vitamin B12 and folic acid are examples of nutrients that require proper levels of stomach acid for their absorption and usage. The presence of adequate acid in the stomach is also required for the conversion of the digestive enzyme pepsin. Pepsin is produced in the stomach from its precursor pepsinogen, which is secreted by cells known as chief cells, and functions to help with the digestion of proteins. Pepsin breaks proteins down into their amino acid components. Since stomach acid is essential to the process of absorbing our nutrients from food, lack of sufficient acid production may lead to decreased health and general well-being.

Ideal stomach acid production is also essential for maintaining a healthy bacterial balance in the intestines. Firstly, acid production in the stomach itself provides a protective barrier that keeps the stomach environment safe. Secondarily, low levels of stomach acid can lead to improperly, incompletely, or poorly-digested food fragments that may cause an imbalance in the growth of normal bacterial flora in the intestines. Achieving the correct balance of flora is a key to maintaining proper digestive function and overall health.

Research also suggests that the body’s capacity to produce stomach acid normally declines as we age. Moreover, stress and other factors may impact proper stomach acid production. Occasional heartburn, bloating, belching, discomfort, and a "sour stomach" may often result from this. Food that we eat enters the stomach through the esophagus, or food pipe. At the junction of the esophagus with the stomach is a muscular structure known as the lower esophageal sphincter (LES). When food enters the stomach for digestion, the LES normally contracts, narrowing the passageway between the esophagus and the stomach and preventing the backflow of stomach contents into the esophagus. A major trigger for the process of tightening the sphincter is the presence of sufficient stomach acid.

When sufficient stomach acid is sensed, the LES will close. However, in conditions where there is a lack of stomach acid, the sphincter remains open, allowing stomach contents, including acid, to flow back through the opening, potentially creating a sense of irritation and discomfort. Adequate stomach acid production is an essential criterion for the sphincter to function properly and prevent the backflow of stomach contents.1

A recent study assessed the incidence and causes of low vitamin B12 levels in elderly patients. The researchers suggest that the incidence of decreased vitamin B12 in the elderly, based on results of some epidemiological studies, is as high as 30-40%. When they looked at the possible causes of low B12 levels in 200 individuals that they followed, they found that food-B12 malabsorption accounted for 60-70% of the cases.2 In other words dietary B12 is bound to foods, generally animal proteins. The protein is normally broken down in conjunction with acid and pepsin in the stomach. However, low production of stomach acid may decrease the efficiency of this process and vitamin B12 remains bound to the protein source, leaving it unavailable to be absorbed. The absorption of countless other nutrients may also be impacted by low stomach acid and pepsin levels.

Gentian Root

Gentian is an herb that is native to parts of Europe and Asia. The root has been used extensively by traditional herbalists to support digestive function due in large part to its bitter constituents. Its present day use as a therapeutic herb dates back to the Romans and Greeks, and related species have even been used in the Indian Ayurvedic system. Various traditional texts classify gentian as a bitter tonic and digestive stimulant, due to its ability to promote the secretion of digestive enzymes. The German Commission E has approved the use of gentian for digestive support, which leads to an increased secretion of saliva and digestive juices.3

Supplementation with the combination of nutrients and cofactors present in Betaine HCl Pepsin & Gentian supports the normal digestive function of the stomach and helps to ensure that the body maintains the efficiency of nutrient absorption from the foods that we eat. Gentian serves to stimulate digestive secretions in the stomach, priming it to digest the food that we eat, while supplemental Betaine HCl and pepsin provide support to the body’s innate production of these digestive factors.

Safety

Take 1 capsule with each meal, or as recommended by a healthcare professional.

Scientific References

1. Wright, Jonathan V., MD and Lane Lenard, PhD. Why Stomach Acid is Good For You. New York: Evans, 2001. 2. Andres E, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ 2004; 171(3): 251-259. 3. Blumenthal M, Goldberg A and J Brinckmann, eds. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications, 2000.



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Benefits - Supports joint function and tissue health*
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Date: December 11, 2006 03:46 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits - Supports joint function and tissue health*

To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage.

Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis. 1,2,3

Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued. 3

Promotes optimal joint comfort, function and flexibility*

Boswellia serrata (Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal models without known side effects. 4

Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesis in vitro, promoting a healthy balanced production of these components of the immune system.5 Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.6 Other trials lend further support to Boswellia’s ability to promote healthy joint function.4,6,7

Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.8

Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response.9 Curcumin also demonstrates in vitro inhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.9,10,11

Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.12 Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results.

Bioperine-Nature’s Absorption Enhancer Boosts Nutrient Absorption*

Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.13 Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.14

Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. 15 These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability.

Sustained Release – For lasting joint comfort and convenient dosing

To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day.

Safety

Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.

Scientific References
1. Vidal y Plana, R.R., Bizzarri, D., Rovati, A.L. Articular cartilage pharmacology: I. In vitro studies on glucosamine and non-steroidal antiinflammatory drugs. Pharmacological Research Communications 1978; 10(6):557-569.

2. Tapadinhas M.J., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68.

3. Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion 1982; 8(3):145-149.

4. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.

5. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R., and Ammon, H.P.T. (1992) Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146.

6. Boswellia serrata. Alternative Medicine Review Monographs – Volume One. 2002.

7. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5.

8. Majeed, M., Badmaev, V., Shivakumar, U., Rajendran, R. Curcuminoids: Antioxidant Phytonutrients. 1995. Piscataway, NJ: NutriScience Publishers.

9. Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae). The Protocol Journal of Botanical Medicine, Autumn 1995:43-46.

10. Rao, S., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol. 1997;49:105-7.

11. Ramsewak, R.S., DeWitt, D.L., Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308.

12. Deodhar, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of curcumin (diferoyl methane). Indian J Med Res 1980;71:632-34.

13. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of Ethnopharmacology 1981;4:229-232.

14. Bioperine®–Nature's Bioavailability Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa Corporation, Piscataway, N.J.

15. Shoba, G., et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998;64(4):353-6.



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Magnesium May Help Reduce Inflammation…
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Date: August 03, 2006 03:39 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Magnesium May Help Reduce Inflammation…

Magnesium May Help Reduce Inflammation… Taking a daily supplement of magnesium may help reduce the levels of a type of inflammation that could lead to heart disease in people with low dietary intake of minerals. According to research published in Nutrition Research (2006, Vol.26: 193-196), Magnesium intake from supplements has an impact on the likelihood of having elevated C-reactive protein (CRP), “Separate from and in addition to dietary intake.” CRP is a pro-inflammatory cytokine—a signaling molecule associated with increased inflammation. The researchers used data from the National Health and Nutrition Examination Survey 1999-2000 and focused on 10,024 people with valid measurements of both CRP levels and dietary and supplemental intake of magnesium. Among other findings, the study showed that people with a total (Dietary plus supplement) magnesium intake below the U.S. recommended daily allowance (420 milligrams for men over 20 and 320 milligrams for women over 30) were found to be 40 percent more probably to have elevated CRP levels.

along with the mineral Magnesium, trace minerals are the catalysts for all the vitamins and other nutrients your body uses for developing and maintaining good health. try out one of these trace mineral supplements which supplies 250mg of Magnesium as well as 72 trace minerals.



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Wasabi Rhizome Cleanse - Supports Phase II Liver Detoxification - Wasabi Health Benefits
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Date: August 01, 2006 10:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Wasabi Rhizome Cleanse - Supports Phase II Liver Detoxification - Wasabi Health Benefits

Most people know of it as a pale-green lump on the side of their plates in Japanese restaurants—a hot, spicy accompaniment to sushi or sashimi. The fiery yet sweet taste perfectly compliments the saltiness of soy sauce and the cool delicacy of raw fish. But wasabi is much more than a burst of culinary flavor, it has been used by traditional herbalists of Japan since the 10th century and is now being rediscovered by modern health practitioners for its stunning health benefits.

Wasabi has powerful detoxification properties, in particular, it supports the immune system and cleanses the liver. Wasabi contains precursors to phytochemicals called isothiocyanates that help remove toxic substances that are stored in the liver’s fatty tissues.

The rare wasabi plant is a natural, potent support to a healthy, cleansed liver that in turn affects the detoxification and cleansing of the entire body. Source Naturals is pleased to bring you this convenient, effective addition to your wellness program.

Wasabia Japonica - Rooted In Health

The wasabi plant (Wasabia japonica) grows naturally in the mountains of Japan in the gravel and sandbars of coldwater streams and rivers. Rare and difficult to grow, it takes three years for a wasabi root or rhizome to reach maturity. Because of its popularity, wasabi is now cultivated hydroponically and in cold, wet environments outside of Japan, such as in New Zealand and Oregon. Traditionally, the rhizome was freshly grated at the table with a sharkskin grater, popular with dishes such as seafood or udon noodles. Now wasabi is usually dried into powder form and made into the pale green paste familiar to most westerners. Often, however, restaurants do not serve real wasabi; since it is so rare and expensive, a dyed horseradish paste is served in most American restaurants.

What makes wasabi so special? It comes from a good family; the brassica vegetables in the cruciferae family include such health giants as broccoli, horseradish, Brussels sprouts, cabbage, cauliflower and kale. All of these are well-known detoxifying plants, and wasabi appears to be the most amazing of them all, with detox capacities far beyond the others in the family because it is loaded with isothiocyanate precursors. This chemical not only gives wasabi its famous “fire,” it is likewise a fireball of detoxification properties.

Phase II Detox

The liver detoxifies the by-products of digestion and other harmful substances through a complex series of chemical reactions often referred to as Phase I and Phase II Detoxification. Phase I enzymes begin the process by taking the toxic molecule and changing it into a bioactive form. This process breaks down toxins. A second set of enzymes, Phase II, then neutralizes the toxin and makes it water soluble for elimination. Wasabi, with its long-chain isothiocyanate precursors, induces the Phase II enzymes. Simply stated, it is the sparkplug that starts Phase II enzymes on their work. This process, all done in the liver, supports the body’s ability to clean itself of impurities.

Part of a Complete Wellness Program

In the modern world, with so many pollutants, it is critical to your health and longevity that you cleanse these toxic compounds from your body. Wasabi, along with a whole food, high-fiber diet and reduction of alcohol consumption, supports the liver— the largest of the vital organs and the key to the digestion and elimination systems and most particularly, the body’s ability to cleanse itself. Source Naturals is pleased to bring you this exceptional product as part of your wellness program.

Research

Depree, JA (1999) Flavour and pharmaceutical properties of the volatile sulphur compounds of Wasabia japonica. Food Research International: 31(5):329-337.

Morimitsu Y, et al. (2002) A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J Biol Chem: 277:3456-3463.

Munday, R (2002) Selective induction of phase II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from Brassica vegetables.

Nutrition and Cancer: 44(1):52-59.

Watanabe, M (2003) Identification of 6-methylsulfinylhexyl isothiocyanate as an apoptosis-inducing component in wasabi. Phytochemistry: 62(5):733-739.

Rose, P (2000) 7-methylsulfinylheptyl and 8- methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis: 21(11):1983-1988.

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Super Powerful Anti-Oxidants: Acai fruit, Green Tea, Mangosteen, Noni Fruit, and Pomegrana
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Date: July 07, 2006 12:00 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Super Powerful Anti-Oxidants: Acai fruit, Green Tea, Mangosteen, Noni Fruit, and Pomegrana

Acai fruit

Acai (pronounced “ah-sigh-ee”) is a powerful berry that grows wild in the Amazon rail forest of Brazil and is considered by many (including Oprah Winfrey) to be one of the top super-foods available! This little, rich berry is no doubt one of the most nutritious foods in the world. Acai is packed full of anti-oxidants (to help combat premature aging), essential fatty acids, dietary fiber and amino acids. In fact, studies show that Acai pulp contains 10 – 30 times the anthocyanins (purple colored antioxidants) of red wine!

Green Tea

Is any other food or drink reported to have as many health benefits as green tea? The Chinese have known about the medicinal benefits of green tea since ancient times, using it to treat everything from headaches to depression. Did you know that green tea has been used as a medicine in China for at least 4,000 years? Today, scientific research in both Asia and the west is providing hard evidence for the health benefits long associated with green tea.

Mangosteen

Mangosteen, also known as “Queen of Fruits”, is a fruit grown in Thailand and Myanmar, and on some southern Caribbean islands. In addition, Mangosteen has a number of compounds, the most prominent being xanthones, a group of compounds that have antioxidant and other potent physiological properties.

Noni Fruit

For over 2000 years, Noni (morinda cetrifolla) has been used for its many beneficial properties. The early Polynesians used it as a general tonic. They found it particularly beneficial for imbalances of the immune, respiratory, digestive, and intestinal system. It was also determined to be helpful for the central nervous system and as an aid for injured muscles, bones and tissue. Currently, scientists are studying possibilities in treating hypertension, high blood pressure, and counteracting the aging process.

Pomegranate

Pomegranate has quickly become one of the most talked about health foods in the past year. Pomegranate fruits contain polyphenols, tannins and anthocyanins – all are beneficial antioxidants. Interestingly, pomegranate juice contains high levels of antioxidants – higher than most other fruit juices, red wine or even green tea. In addition, preliminary evidence indicates pomegranate is particularly beneficial for cholesterol and blood pressure.



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Lutein to fight age-related macular degeneration!
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Date: February 27, 2006 05:53 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Lutein to fight age-related macular degeneration!

Lutein: The Antiordinary Antioxidant

Lutein belongs to a class of compounds known as carotenoids. Carotenoids in general are yellow, orange, or red pigments responsible for many of the colors of the foods we consume each day. To date, over 600 carotenoids have been identified in nature, but are only produced by plants, algae and bacteria leaving humans and animals to consume carotenoids in the diet. Forty to fifty carotenoids are consumed in the typical US diet, but only 14 have been detected in the blood, indicating a selective use of specific carotenoids by the body. Lutein is one of these carotenoids found in the blood and has been increasingly associated with eye health over the last decade.

Lutein’s role in eye health

In the human eye, lutein is concentrated in the center of the retina in an area known as the macula. Lutein is deposited in the macula through the lutein we consume in out diet or through supplements. This area is responsible for human central vision and is colored intensely yellow due to high concentrations of lutein. Lutein is thought to be beneficial for eye health by reducing damage in the eye in two ways: 1) by absorbing blue light (blue light is thought to increase free radical formation in the eye) and 2) by acting as an antioxidant, reducing damage in the eye caused by free radicals. Leading carotenoid researchers believe these functions may lead to a reduced risk of age-related macular degeneration (AMD) and cataracts.

Age-related macular degeneration

Macular degeneration is the leading cause of blindness in the USA in those over 65. twenty-five and thirty million people are afflicted worldwide and currently there are no effective treatments for the disease. The disease has two forms known as dry and wet AMD.

Ninety percent of AMD cases diagnosed are the dry form. In dry AMD, also referred to as early AMD, debris deposits under the center of the retina (known as the macula) interfering with its normal function. Parts of the macula atrophy, causing the central vision to slowly become dimmer or more blurry. Wet age-related macular degeneration, also known as late AMD, often develops in areas where dry AMD exists. Abnormal blood vessels grow and leak blood and fluid under the macula, causing scarring, which leads to rapid loss of central vision.

Dr. Joanna Seddon published one of the first studies demonstrating a link between lutein intake and AMD risk in 1994 (1). This epidemiological study compared the risk of developing AMD to nutrient intake and showed a significant reduction in risk for developing AMD as lutein intake reached 6mg per day (57% reduction in risk). Since the Seddon study, researchers have shown that increasing dietary lutein intake raises blood levels of lutein as well as levels of lutein in the eye (2). Bone et al. demonstrated that eyes with higher levels of lutein were less likely to be afflicted with AMD (3).

The latest clinical trial that investigated lutein’s role in AMD is known as the lutein antioxidant supplementation trial (L.A.S.T) (4). This study evaluated the effects of lutein supplementation for one year in 90 veterans diagnosed with dry AMD. Supplementation with lutein in these subjects significantly increased the concentration of lutein in the macula. Improvements in visual function were also detected with lutein supplementation. Glare recovery, visual acuity, and contrast sensitivity were all improved. This study continues to build on clinical evidence that the dry form of AMD may be responsive to changes in nutrition.

Cataracts

A cataract is a natural clouding of the lens, the area of the eye responsible for focusing light and producing clear, sharp images. For most people, cataracts are a natural result of aging. Currently in the US, cataracts are the second leading cause of blindness in the elderly behind AMD.

Lutein is the major carotenoid that has been identified in the human lens asn is thought to provide similar benefits to the leans that are seen in the retina. Two large epidemiological studies consisting of >70,000 women (age 45-71) and >30,000 men (age 45-75) compared the risk of cataract extraction to nutrient intake (5,6). Similar to AMD, a significant reduction in risk of cataract extraction was associated with lutein intakes of 6mg per day (20% reduction in risk). Besides cataract extraction, higher levels of lutein consumption have been associated with a decreased risk of cataract development and improvements in visual acuity and glare sensitivity in people with age-related cataracts.

Lutein consumption

The richest source of free lutein in the typical US diet are dark green leafy vegetables, with the highest concentration found in kale followed by spinach.

The average daily lutein intake is low, average between 1-2 mg/day. Currently there is no recommendations of the dietary guidelines for Americans 2005 (9 servings of fruits and vegetables every day) you would consume between 4 and 8 mg of lutein a day (7). Epidemiological evidence, animal models, and clinical data have indicated levels of 6-10 mg a day may be necessary to realize the health benefits associated with lutein consumption. By continuing to increase our intake of lutein, we begin to ensure the optimal health of our eyes.

References:

Seddon et al. (1994) dietary carotenoids, vitamin a, c, and e, and advanced age-related macular degeneration. Eye disease case-control study group. JAMA. 272: 1413-20.

Bone et al. (2000) Lutein and zeaxanthin in the eyes, serum and diet of human subjects. Exp. Eye Res. 71: 239-45.

Bone et al. (2001) Macular pigment in donor eyes with and without AMD: a case-control study. Invest. Ophthalmal. Vis Sci. 42: 235-40.

Richer et al. (2004) Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-relaged macular degeneration: the veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 75: 216-30.

Brown et al. (1999) A prospective study of carotenoid intake and risk of cataract extraction in the US men. Am. J. Clin. Nutr. 70: 517-24.

Chasen-Taber et al. (1999) A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am. J. Clin. Nutr. 70: 509-16

HHS/USDA. Dietary Guidelines for Americans 2005. //www.healthierus.Gov/dietaryguidelines/CDC. National health and nutrition examination survey data 2001-2002. //www.cdc.gov/nchs/about/major/nhanes/nhanes01-02.html

Brandon lewis, Ph.D. is the applied research and Technical services manager at kemin health, L.C. in des moines, iowa. His responsibilities include the initiation and management of laboratory projects pertaining to the inclusion and analysis of kemin ingredients in vitamins and dietary supplements, as well as developing new applications and prototypes that include kemin ingredients. Prior to joining kemin, Brandon was enrolled at the university of Florida where he received his Ph.D. in Nutritional Science from the department of Food Science and Human Nutrition.



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Rutozym - Systemic Enzyme Supplement with Nattokinase
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Date: February 22, 2006 05:08 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Rutozym - Systemic Enzyme Supplement with Nattokinase

Wobenzyme / Naturally Vitamins

Choose all-vegetarian Rutozym for smoother blood flow, stronger blood vessel walls, and a pacified inflammatory response.

Take Control of Your Heart Health

Heart disease claims an American life every 34 seconds, making heart disease the leading cause of death in the United States. Not only men, but also one out of every two women are affected by heart disease and stroke.

According to the American Heart Association, misperceptions about the risks of cardiovascular disease for women still exist, even though 50 percent of people with heart disease today are women, and more women than men die of stroke. After menopause, women are even more likely to have heart attacks than men.

Because of today’s standard of American fast-food diets and poor lifestyle habits, many people have high cholesterol and hypertension and suffer from circulatory disorders. People with excessive body fat are more likely to develop heart disease and stroke, even if they have no other risk factors. Obesity increases the strain on the heart, which contributes to coronary heart disease and can also make diabetes more likely to develop.

People in many other countries have somehow managed to maintain healthier hearts naturally. One reason may be the enzymes in their diet.

Nattokinase and Cardiovascular Health Experts credit much of Japan’s reputation for the lowest heart disease rate to nattokinase, an enzyme in the fermented soy-based cheese called natto. Although a Japanese staple for over 2000 years, the sticky, odorous cheese is, needless to say, an acquired taste. Fortunately the advantage is in the enzyme, now available in Rutozym.

Hiroyuki Sumi, MD, a researcher of the Japan Ministry of Education, discovered the enzyme and its remarkable benefits while searching for a natural way to break down excess fibrin in the blood, a major cause of heart disease, stroke, senility and even sudden death. Pleased with how successfully it dissolved fibrin and improved blood flow, Sumi (affectionately known as “Dr. Natto”) gave nattokinase its name.

Rutozym

In the 1980s when the story of systemic enzyme therapy was well underway, scientists invited Dr. Karl Ransberger, founder of the enzyme formula Wobenzym, to Japan to present his discoveries in enzyme research. The country’s low rate of heart attacks and its dietary link to natto intrigued Dr. Ransberger. Eager to investigate its potential use in alternative healthcare, he carried several pounds of natto home to Europe. After years of testing, his research confirmed that nattokinase did, in fact, improve blood flow by removing cross-linked fibrin from the blood stream.

Based on his nearly five decades of experience with the proteolytic Natural Support for Cardiovascular Health (protein-splitting) enzymes in Wobenzym, Dr. Ransberger knew that an enzyme mixture would prove even more effective than a single enzyme formula. So, to the nattokinase he added two of the enzymes in Wobenzym known to normalize inflammation. Then he increased its total effect with a proprietary flavonoid complex. As a result, the formula not only improved blood flow, it strengthened the integrity of blood vessels and helped manage the body’s systemic inflammatory response, promoting better overall health. Dr. Ransberger teamed up with Naturally Vitamins to further develop, test and perfect the Rutozym formula.

Today, Dr. Ransberger’s legacy lives on through Naturally Vitamins’ continuing research on systemic enzyme therapies. Most recently, Naturally began a 2003 clinical trial in Chicago to evaluate the benefits of Rutozym in heart patients. In cooperation with the leading manufacturer of Nattokinase in Japan, the trial will examine the effects of Rutozym on blood viscosity (thickness) and blood pressure. On completion, the results will be published in a peer-reviewed journal.

How Rutozym Works

Rutozym works by reinforcing your body’s own enzymes. As the building blocks of life, enzymes make every chemical action in the body possible. Though you are born with thousands of enzymes, as time goes by your supply diminishes. Scientific research shows that replenishing your natural supply with systemic enzymes can support your body’s immune functions and healing processes.

Rutozym is a plant-based systemic enzyme formula containing nattokinase. But it also contains other proteolytic enzymes and ingredients carefully blended to improve heart health and enhance your body’s innate ability to heal. Rutozym contains the proteolytic enzymes bromelain (from pineapple) and papain (from papaya) known to effectively rebalance the body’s inflammatory response. Rutozym also contains rutin to strengthen capillaries and other connective tissue, and white willow bark, which is often called “nature's aspirin.”

While doctors often recommend an aspirin a day to help prevent heart disease and stroke, the daily use of Rutozym has no gastrointestinal side effects. With new research, the scope of Rutozym’s benefits continues to increase. Supplement Facts

Serving Size: 2 Tablets
Servings Per Container: 60 amnt/serving %daily
Nattokinase (20,000 FU/gm) 25mg *
Bromelain (2,450 GDU/gm) 90mg *
Papain N.F. (2,400 USP Units/mgl) 100mg *
Rutin bioflavonoid Complex (rutosides & rutinosides) 120mg *
White willow bark extract (15% solicin/7% plyphenols) 100mg *

* Daily value not established.

Other Ingredients: Plant Fiber, Povidone, Modified Cellulose Gum, Colloidal Silica, Titanium Dioxide Mineral, Vegetable Stearic Acid and pH-Resistant Enteric Coat.

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California Proposition 65 (Prop 65) and Progesterone Cream Warnings
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Date: February 17, 2006 06:29 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: California Proposition 65 (Prop 65) and Progesterone Cream Warnings

Scientific Safety Information on Progesterone

California Proposition 65 (Prop 65) and Progesterone Cream Warnings Amy Kosowski, M.S., LDN

Prop 65: What is it?

Proposition 65, the Safe Drinking Water and Toxic Enforcement Act of 1986 , was enacted as a ballot initiative in the state of California in November of 1986. The Proposition was intended by its authors to protect California citizens and the State's drinking water sources from chemicals known to cause cancer, birth defects or other reproductive harm, and to inform citizens about exposures to such chemicals 1.

Proposition 65 requires the Governor to publish, at least annually, a list of chemicals “known to the state to cause cancer or reproductive toxicity .” Progesterone, as well as other human hormones, appear on this list 1. Set forth below is the information that formed the bases for the addition of progesterone to the Prop 65 list by the California Office of Environmental Health Hazard Assessment (“OEHHA”).

Prop 65 and Progesterone - Perspective

In August of 2004, OEHHA published a document stating the rationale for the addition of Progesterone to the Prop 65 list 2. This document is a review of human, animal, and in vitro studies that used progesterone, synthetic progestins, and other progestagens (progesterone-like compounds). Experimental data from the use of all of these compounds were mixed together, along with data from studies using other steroid hormone derivatives (mainly synthetic estrogens) and many different methods of administration.

Although this review covered the existing scientific literature on progesterone and its many derivative compounds, there are many problems with the type of data analysis that was employed.

First, progesterone is endogenous to humans and necessary for bone and reproductive health while progestins and other synthetic progestagens are not. Progestins and progestagens are similar in molecular structure to progesterone, but when they bind to progesterone receptors, their effects are usually much stronger and more likely to cause abnormal physiologic responses 3, 4. Furthermore, the majority of the studies concerning the health effects of these progesterone derivatives involved combinations with synthetic estrogens 2-4.

There were very few studies mentioned in the 2004 document that used exclusively bio-identical progesterone (the kind found normally produced by humans as well as that used in progesterone creams), and those studies that did were at supra-physiologic doses (very high). The doses of progesterone ranged from 10-1000 times the dose usually recommended by manufacturers of progesterone creams 2, although in a few cases, the doses were closer to the recommended dosages.

The route of administration of progesterone is also at issue. All of the studies cited in the OEHHA document used either oral, injected, or suppository forms of hormones; none was conducted using transdermal creams. This is an important consideration because hormones absorbed through the skin are metabolized differently than hormones that are administered via other routes 5, 6.

Putting it Together

While the OEHHA Prop 65 reference document on progesterone 2 is a broad survey of the published scientific literature examining the potential effects of the pharmaceutical use of progesterone and its synthetic derivatives, it is not clear at all that these effects would be seen with the use of low-dose progesterone creams.

The OEHHA Prop 65 progesterone document evaluates a broad range of information regarding progesterone and synthetic materials that are not natural progesterone. The conclusion reached was not challenged, and it is on that basis that progesterone creams now carry the Prop 65 warning.



References:

1 California OEHHA Web Site: //www.oehha.ca.gov/prop65/p65faq.html .

2 Reproductive and Cancer Hazard Assessment Section, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency (2004) Evidence on the developmental and Reproductive Toxicity of Progesterone.

3 Campagnoli C, Abba C, Ambroggio S, Peris C (2005) Pregnancy, progesterone and progestin in relation to breast cancer risk. J Steroid Biochem Mol Biol 97(5):441-450.

4 Campagnoli C , Clavel-Chapelon F , Kaaks R , Peris C , Berrino F (2005) Progestins and progesterone in hormone replacement therapy and the risk of breast cancer. Steroid Biochem Mol Biol 2005 96(2):95-108.

5 de Lignieres B, Dennerstein L, Backstrom T (1995) Influence of route of administration on progesterone metabolism. Maturitas 21:251-257.

6 Gompel A, et al. (2000) Progestins were also proapoptotic in normal as well as in hormone-dependent breast cancer cells. Steroids 65(10-11):593-598.

7 Bu SZ ( 1997) Progesterone induces apoptosis and up-regulation of p53 expression in human ovarian carcinoma cell lines. Cancer 79(10):1944-50.

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Benefits of L-Carnitine
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Date: February 12, 2006 03:24 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of L-Carnitine

Benefits

Helps the body burn fat for energy*

L-Carnitine promotes energy production in cells by transporting fatty acids into the mitochondrion. Its primary function is to transfer long-chain fatty acids across the inner mitochondrial membrane. Fatty acid molecules are activated to coenzyme A (CoA) esters in the cytoplasm of the cell, and then esterified to L-Carnitine. The combination of a fatty acid molecule and L-Carnitine is called “acyl-carnitine.” Much of the body's L-Carnitine content is stored in the form of acyl-carnitine.1

The mitochondrion is the cell’s energy-generating furnace. Called an “organelle,” the mitochondrion is a self-contained structure inside the cell. Like all cellular structures, the mitochondrion is surrounded by a membrane. This membrane is an impenetrable barrier to acyl-CoA esters; passage across the membrane requires L-Carnitine as a transporter. On the inside of the mitochondrial membrane, the acyl-CoA esters are made available to be metabolized through the process of beta oxidation. One of the key metabolic byproducts of this process is acetyl-CoA, also called “active acetate,” which enters the Krebs cycle (also known as the “citric acid cycle”) to supply fuel for production of ATP, the cell’s primary energy “currency.” L-Carnitine shuttles excess fatty acid residues out of the mitochondrion, and in this role is essential for preventing toxic buildup of fatty acids inside the mitochondrion.

Evidence suggests that L-Carnitine and short chain acyl-carnitine esters can protect the mitochondrion from adverse effects of drugs and toxic chemicals. L-Carnitine has been shown to protect animals form cardiotoxins and decrease mortality rate in animals with diphtheria, due to this cardioprotective effect.2

Helps maintain a healthy heart and cardiovascular system*

Muscle tissue contains a high concentration of L-Carnitine. With its constant energy needs, heart muscle tissue is especially rich in L-Carnitine. If the body’s ability to biosynthesize L-Carnitine is compromised, energy production in muscle tissue is impaired, and a toxic buildup of fatty acids can occur.3 Defective production of L-Carnitine by the body can result from a variety of factors, including kidney or liver malfunction, increased catabolism or the inability of tissues to extract and retain L-Carnitine from the blood.

Along with glucose and lactate, fatty acids are the primary oxidation fuel for the heart. A considerable amount of scientific data from animal experiments indicates that L-Carnitine protects the heart under conditions of hypoxia, or low oxygen. In addition to the oxidation of fat for energy in the cell, L-Carnitine is involved in the metabolism of glucose.4 Evidence of L-Carnitine’s role in glucose metabolism was uncovered in a small trial on 9 diabetic individuals. Given intravenously, L-Carnitine improved insulin-mediated glucose utilization and insulin sensitivity.5

Depletion of the body’s L-Carnitine supply is linked to various abnormal states, especially of the heart muscle. The effect of L-Carnitine on hypoxic (oxygen-starved) isolated heart muscle tissue has been studied.6 At high concentrations, L-Carnitine demonstrates a clear-cut ability to potentiate the contractility of isolated heart muscle tissue, indicating the L-Carnitine has a strengthening effect on the heart. L-Carnitine has been shown to improve the performance of rats subjected to fatigue test.

Research has revealed that in animals and humans with defective heart muscle, the amount of free L-Carnitine (not bound to fatty acids) is reduced. Administration of L-Carnitine to hamsters prevents damage to the heart muscle. Given to humans with angina, L-Carnitine was found to improve exercise tolerance. In a small study, patients with congestive heart failure showed gains in heart function with oral consumption of L-Carnitine, reportedly by restoring normal oxidation of fatty acids.7 In heart valve replacement patients, L-Carnitine has been shown to increase the valve tissue levels of ATP, pyruvate and creatine phosphate, which are key cellular energy substrates. In a controlled study, L-Carnitine was administered to 38 patients prior to open heart surgery. Prior to surgery, heart circulatory function, as assessed by measurements of hemodynamics, was “good” in all 38. While there was evidence of a “preserving” effect of L-Carnitine on heart cells, no differences in cardiac performance were observed. These results suggest that noticeable improvements in heart muscle performance with L-Carnitine are most likely to occur in people with compromised hearts.8

It has been suggested that L-Carnitine favorably influences blood lipids. Preliminary evidence of this was seen in a small open trial on 26 patients who took 3 grams of L-Carnitine daily for 40 days. Blood levels of cholesterol and triglycerides dropped substantially, while the ratio of total to HDL cholesterol–– a known marker of cardiovascular health––markedly improved.9

While L-Carnitine is not a treatment for heart disease, (nor should it be used as a substitute for medical treatment) the results of these and other studies suggest that oral consumption of L-Carnitine has a beneficial influence on maintaining a healthy heart and cardiovascular system.



Safety

Suggested Adult Use: Take 1 to 4 capsules daily without food.

L-Carnitine is considered to be very safe for oral consumption. L-Carnitine is generally well tolerated, even at doses as high as 15 grams daily. Toxicity or overdosage has not been reported.10



Scientific References
1. Wagenmakers, A. L-Carnitine supplementation and performance in man. Brouns, F. ed. Advances in Nutrition and Top Sport. Med Sport Sci. Basel, Karger, 1991;32:110-27.
2. Arrigoni-Martelli, E., Caso, V. Carnitine protects mitochondria and removes toxic acyls from xenobiotics. Drugs Exptl. Clin. Res. 2001;27(1):27-49)
3. Pepine, C.J. The therapeutic potential of carnitine in cardiovascular disorders. Clinical Therapeutics 1991;13(1):2-21.
4. Calvani, M., Reda, E., Arrigoni-Martelli, E. Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions. Basic Research in Cardiology 2000;95(2):75-83.
5. Capaldo, B. et al. Carnitine improves peripheral glucose disposal in non-insulin-dependent diabetic patients. Diabetes Research and Clinical Practice 1991;14:191-96.
6. Fanelli, O. Carnitine and acetyl-carnitine, natural substances endowed with interesting pharmacological properties. Life Sciences 1978;23:2563-2570.
7. Kobayashi, A., Masumura, Y., Yamazaki, N. L-Carnitine treatment for congestive heart failure-experimental and clinical study. Japanese Circulation Journal 1992;56:86-94.
8. Pastoris, O. et al. Effect of L-Carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing heart surgery. Pharmacological Research 1998;37(2):115-22.
9. Pola, P. et al. Carnitine in the therapy of dyslipidemic patients. Current Therapeutic Research 1980;27(2):208-16.
10. L-Carnitine. PDR for Nutritional Supplements. First Ed. 2001.Montvale, NJ:Medical Economics.



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Benefits of Acetyl-L-Carnitine
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Date: February 12, 2006 01:55 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Acetyl-L-Carnitine

Benefits

Supports cognitive function*

ALC has been studied for its effect on cognitive performance and emotional health in the elderly. In a single-blind, placebo-controlled trial, 481 elderly subjects exhibiting mild memory impairment improved their scores on a memory test after taking 1500 mg of ALC a day for 90 days.2 Hospitalized elderly people taking ALC have shown improvements in mental outlook.3 While ALC is not a treatment or cure for Alzheimer's disease, double-blind studies suggest it may help slow the rate at which early-stage Alzheimer's patients deteriorate.4 In particular, ALC seems to benefit short-term memory in these patients.5

Supports biosynthesis of acetylcholine, a key neurotransmitter for brain and nerve function* Brain function requires coordinated communication between brain cells. Brain and nerve cells ("neurons") communicate across tiny cell-to-cell gaps called "synapses." The passage of an electrical impulse from one neuron to the next requires a "neurotransmitter." When an electrical signal arrives at the synaptic junction, the neuron releases a neurotransmitter into the synapse. The neuron on the other side of the synapse contains receptors for the neurotransmitter; these receptors bind the neurotransmitter, triggering a series of chemical events that sends a new electrical signal down the membrane of the receiving neuron. Neurotransmitters work together like an orchestra to transmit information throughout the brain and nervous system. Acetylcholine is the most abundant neurotransmitter in the body, regulating activities of vital organs, blood vessels and communication between nerves and muscles. In the brain, acetylcholine helps facilitate memory and learning as well as influence emotions. ALC is structurally similar to acetylcholine, and brain neurons stimulated by acetylcholine are receptive to stimulation by ALC.6 It has been shown experimentally that ALC supplies acetyl groups for the biosynthesis of acetylcholine.7 ALC's hypothesized cholinomimetic (acts like acetylcholine) activity has led researchers to investigate its effects on mental function and emotional health.8

Helps supply the brain with energy by improving energetics in the mitochondrion*

The acetyl groups donated by ALC can be used to synthesize acetyl-CoA, the key substrate for energy metabolism in the mitochondrion. 9 Acetyl-CoA enters the Krebs cycle, the mitochondrial mechanism that generates cellular energy in the form of ATP. ALC easily crosses the blood-brain barrier, allowing it to play various roles in maintaining brain neuron (nerve cell) function. When given by oral administration, the concentration of ALC is increased in the blood and cerebrospinal fluid.10

Stabilizes intracellular membranes*

ALC was found to improve membrane phospholipid metabolism in early-stage Alzheimer's patients.11 Phospholipids are structural components of brain cell membranes that regulate neuron function. ALC donates acetyl groups that can be used to modify the functional activity of proteins in neuronal membranes.12 ALC thus plays a role in maintaining membrane function. ALC also increases membrane stability and structural integrity.13

Increases nerve growth factor production*

The body produces various specialized proteins called "growth factors" which are essential to growth and repair of tissue. Nerve Growth Factor (NGF) protects neurons from death, prolonging survival of neurons in both the central and peripheral nervous systems. It is theorized that aging of the central nervous system is associated with a loss of NGF. ALC has shown the ability to reverse age-related decrease in the binding of NGF to its receptors in neuron membranes.14 Given to aged rats, ALC increases the level and utilization of NGF in the rats. ALC protects cholinergic neurons (nerve cells stimulated by acetylcholine) in rats from degeneration due to lack of NGF.15 These results, together with other data from animal studies, suggest that ALC positively influences NGF activity.16

Has a protective influence on brain neurons*

Several animal studies have revealed that ALC exerts a protective effect on neurons. In one experiment, brain cells from rats exposed to NMDA, a known neurotoxin, were protected by being simultaneously exposed to ALC.17 Rats injected with ALC were protected from mortality caused by the neurotoxin MPP+.18 ALC has been shown to raise levels of glutathione, a highly valuable antioxidant, in isolated mouse brain tissue.19 ALC prevents buildup of malondyhaldeyde, a marker of lipid peroxidation.20 ALC is also a chelator of iron, which can generate free radicals. It also reinforces antioxidant mechanisms in the brain.21 As a whole, data from test tube and animal studies, showing that ALC has a protective, restorative effect on brain neurons and neuronal energetic processes, suggest that ALC is an anti-aging nutrient for the brain. This hypothesis is supported by human studies demonstrating measurable benefits for brain function in elderly persons taking ALC by oral consumption.


Safety
Suggested Adult Use: 1 to 4 capsules daily.
ALC is considered safe and well-tolerated when consumed orally. ALC has been administered in doses as high as 3 grams per day for periods of two to six months, with no reports of serious side effects. Some patients have experienced occasional mild abdominal discomfort, nausea, skin rash, restlessness, vertigo and headache. The severity and incidence of these side effects are reported as minor.22

Scientific References
1. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
2. Salvioli, G. Neri , M. L-acetylcarnitine treatment of mental decline in the elderly. Drugs Exptl. Clin. Res. 1994; 20(4):169-76.
3. Tempesta, E, et al. L-acetylcarnitine in depressed elderly subjects. A cross-over study vs. placebo. Drugs Exptl. Clin. Res. 1987;8(7):417-23.
4. Spagnoli, A et al. Long-term acetyl-L-carnitine treatment in Alzheimer's disease. Neurology 1991;41:1726-32.
5. Rai, G et al. Double-blind, placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's dementia. Curr. Med Res. Opin. 1990;11:638-47.
6. Falchetto, S, Kato, G, Provini, L. The action of carnitines on cortical neurons. Can J Physiol Pharmacol 1971; 49(1):1:7.
7. Dolezal, V., Tucek, S. Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices. J Neurochem 1981;36(4):1323.30.
8. Passeri, M, et al. Mental impairment in aging: selection of patients, methods of evaluation and therapeutic possibilities of acetyl-L-carnitine. Int. J. Clin. Pharm. Res. 1988;8(5):367-76.
9. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
10. Parnetti, L, et al. Pharmacokinetics of IV and oral acetyl-L-carnitine in multiple dose regimen in patients with senile dementia of Alzheimer type. Eur. J. Clin Pharmacol 1992;42:89-93.
11. Pettegrew, JW, et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiology of Aging 1995;16(1):1-4.
12. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
13. Arduni, A, et al. Effect of L-carnitine and acetyl-L-carnitine on the human erythrocyte membrane stability and deformability. Life Sci 1990;47(26):2395-2400.
14. Taglialatela, G, et al. Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine. Biochem Pharmacol 1992;44(3):577-85.
15. Taglialatela, G, et al. Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats. Exp Gerontol 1994;29(1):55-56.
16. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
17. Forloni, G, Angeretti, N, Smiroldo, S. Neuroprotective activity of acetyl-L-carnitine: studies in vitro. J Neurosci Res 1994;37(1):92-6.
18. Steffen, V, et al. Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine. Hum Exp Toxicol 1995;14(11):865-71.
19. Fariello, RG, et al. Systemic acetyl-L-carnitine elevates nigral levels of glutathione and GABA. Life Sci 1988;43(3):289-92.
20. Calvani, M, et al. Action of acetyl-L-carnitine in neurodegeneration and Alzheimer's disease. Ann Ny Acad Sci 1992;663:483-86.
21. Calvani, M, Carta, A. Clues to the mechanism of action of acetyl-L-carnitine in the central nervous system. Dementia 1991;2:1-6.
22. Zdanowicz, M. Acetyl-L-carnitine's healing potential. Continuing Education Module. New Hope Institute of Retailing. October, 2001.


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Naturally enhanced powers
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Date: February 10, 2006 06:40 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Naturally enhanced powers

Curcumin is poorly absorbed in the GI tract, which limits its effectiveness. Fortunately, nature has an answer, in the form of piperine, a component of black pepper. Piperine has been shown to increase Curcumin absorption by as much as 2000% when the two are consumed together. For this reason Doctors best has combined Curcumin with Bioperine, a patented black pepper extract that supplies 95%-98% piperine.

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Folic Acid: Strengthening the Immune System in the Elderly
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Date: January 09, 2006 09:38 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Folic Acid: Strengthening the Immune System in the Elderly

Folic Acid: Strengthening the Immune System in the Elderly

By Greg Arnold, DC, CSCS, December 20, 2005, abstracted from “Dietary folate improves age-related decreases in lymphocyte function” in the January 2006 issue of the Journal of Nutritional Biochemistry Recent research has elucidated health-promoting roles for folic acid beyond that of insuring normal development of the fetus. In addition to helping decrease neural tube defects,1 folic acid can also help treat inflammatory bowel disease 2 improve memory 3 and help decrease an amino acid in the body, homocysteine,4 that increases heart disease risk.5 Now a new study 6 has found another way that folic acid can help us age more gracefully: by helping strengthen our immune system. Recognizing the importance of nutrition in the overall health of the immune system 7 and knowing that certain types of immune system cells, called “T cells”, decrease with age,(8,9) researchers fed 11-month-old and 23-month-old male rats either a control diet or a diet fortified with 35.7 mg per kg of folic acid for three weeks. Researchers found “a significant” increase in immune system strength in the folic acid group, specifically that of increased T cell levels, other immune system proteins called IL-2, IL-4, and anti-cancer proteins called “tumor necrosis factor”. While the study reaffirmed the immune system’s weakening with increasing age, the researchers concluded that “supplementing…with additional folate improves [immune system function] and that dietary folate requirement may be higher in the older population than in the younger population to support immune functions.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:ChiroDocPSUalum@msn.com or visiting his website www.CompleteChiropracticHealthcare.com Reference:
1 “Spina Bifida and Anencephaly Before and After Folic Acid Mandate --- United States, 1995--1996 and 1999—2000” from MMWR Weekly 2004; 53(17): 362-365
2 Danese S. Homocysteine triggers mucosal microvascular activation in inflammatory bowel disease. Am J Gastroenterol. 2005 Apr;100(4):886-95
3 “The First Ever Dementia Conference Opens In Washington, DC” posted on the Alzheimer’s Association Website www.alz.org/preventionconference/pc2005/overview.asp
4 Daly S. Low-dose folic acid lowers plasma homocysteine levels in women of child-bearing age. QJM. 2002 Nov;95(11):733-40
5 Stampfer J. Homocysteine levels and cardiovascular disease. Am Fam Physician. 1997 Oct 15;56(6):1568, 1571-2
6 C.J. Field, I.R. Johnson and P.D. Schley, Nutrients and their role in host resistance to infection, J Leukoc Biol 71 (2002), pp. 16–32
7 L. Haynes, S.M. Eaton, E.M. Burns, M. Rincon and S.L. Swain, Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo, J Immunol 172 (2004), pp. 5194–5199
8 R.B. Effros, Replicative senescence of CD8 T cells: effect on human ageing, Exp Gerontol 39 (2004), pp. 517–524

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Thyroid Energy from Now Foods
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Date: January 05, 2006 10:28 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Thyroid Energy from Now Foods

"THYROID HEALTH" Thyroid Energy

  • Balances thyroid hormone production
  • Helps naturally support glandular function
  • 1 Full Gram of L-Tyrosine
  • Enriched with B- Vitamins, Zinc, Copper and Selenium

References
1) Balch, James & Phyllis, Prescription for Natural Healing Third Edition, Avery, Penguin Putnam, 2000
2) Norman, James M.D., Thyroiditis: Definitions, Causes and Treatments, Endocrineweb.net, 2004
3) Ross, Julia, The Diet Cure, Penguin Books, 2000



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Astaxanthin - PHYTONUTRIENT ANTIOXIDANT
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Date: December 28, 2005 10:20 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Astaxanthin - PHYTONUTRIENT ANTIOXIDANT

"PHYTONUTRIENT ANTIOXIDANT" Astaxanthin

  • Potent Natural Antioxidant
  • More Powerful Than Vitamin E And Other Carotenoids
  • Supports Healthy Immune and Cardiovascular Function
  • Well-Researched With Documented Results
  • High Quality BioAstin® Astaxanthin

Carotenoids are a class of lipid-soluble natural pigments found in plants, as well as in phytoplankton and certain fungi and bacteria. The red, orange and yellow colors seen in fruits and vegetables are from carotenoids. When various aquatic animals such as salmon and shrimp eat plants containing some of the over 700 compounds that make up the carotenoid class, those animals are also decorated with the same brilliant colors. However, carotenoids do more than provide color - they’re powerful phytonutrient antioxidants. Beta carotene, lutein, and lycopene are some of the more well-known carotenoids, but the most powerful found to date is astaxanthin.

Astaxanthin is a fat-soluble carotenoid with a unique molecular structure that makes it an extremely effective antioxidant. The PDR® Medical Dictionary 2nd Edition defines an antioxidant as, “An agent that inhibits oxidation; any of numerous chemical substances, including certain natural body products and nutrients, that can neutralize the oxidant effect of free radicals and other substances.” Not only is astaxanthin a potent free radical scavenger, but it also can protect against oxidation, which limits the number of free radicals produced. Additionally, it’s very effective at quenching a molecule called singlet oxygen, a harmful reactive oxygen species formed through normal biological processes. Singlet oxygen possesses a high amount of excess energy that must be released to keep it from damaging other cells. Astaxanthin absorbs this energy and dissipates it as heat, and in the process returns the singlet oxygen to a grounded state.

A growing body of research is showing that astaxanthin is the creme de la creme of phytonutrient antioxidants. Studies comparing astaxanthin to other carotenoids have shown it to possess antioxidant activity up to 10 times stronger than that of beta carotene, canthaxanthin, lutein and zeaxanthin.4 A study published in 1990 conducted by Kurashige and associates compared the effectiveness of vitamin E and astaxanthin for the prevention of lipid peroxidation. The results showed that astaxanthin is 100-500 times more effective in preventing lipid peroxidation in vivo than vitamin E.5

Astaxanthin in algae provides protection against the effects of ultraviolet (UV) light exposure, and studies are showing that this protective effect is also imparted with dietary astaxanthin. Scientists believe that astaxanthin effectively scavenges the oxygen radicals produced through photo-oxidation caused by UV exposure. A 1995 study by Savoure and associates studied the protective effects of astaxanthin, beta carotene and retinol against UVinduced photo-oxidative stress. The results showed that astaxanthin is extremely effective in preventing increases of certain polyamines created through photo-oxidation, which damages skin. A particular polyamine was found to increase only 1.5-fold in subjects fed astaxanthin, whereas subjects in the control group experienced a significant 4.1- fold increase. It was concluded that astaxanthin works through a particular enzyme, increasing this enzyme’s consumption of polyamines in response to irradiation.

Research has shown that astaxanthin also offers cardioprotective effects through its ability to decrease oxidation of HDL (“good” cholesterol), which is a cholesterol transporter in the blood. It‘s well established that high levels of HDL and low levels of LDL (“bad” cholesterol) are desirable for healthy cardiovascular function, so protecting HDL from oxidation means there’s more circulating in the bloodstream. In a 1992 study by Murillo, subjects were fed dietary astaxanthin for 30 days. HDL cholesterol increased 57mg/dL, compared to the control diet (42.4 mg/dL). LDL cholesterol decreased from 12.5 mg/dL to 9.6 mg/dL. Clearly, astaxanthin exhibited an influence on the ratio of these two lipoproteins.

We can thank the lobster for the discovery of astaxanthin. Researchers working with an extract of the lobster Homarus astacus first characterized astaxanthin in 1938. It was soon discovered that astaxanthin is abundant in nature, although mostly in very low concentrations. The greatest source found is in green algae called Haematococcus pluvialis, which also contains other carotenoids such as beta carotene and lutein. NOW® Foods Astaxanthin supplies 4mg of this effective phytonutrient antioxidant and is an excellent source of this outstanding member of the carotenoid family. The astaxanthin used for our product is BioAstin® supplied by the Cyanotech Corporation, one of the premier suppliers of highquality astaxanthin taken from Haematococcus pluvialis, the richest natural source discovered. In addition to Astaxanthin, NOW® offers other carotenoids, including Lutein, Beta Carotene and Lycopene. Research continues to support the inclusion of carotenoids in the diet to support overall health. This is even truer for those with less than perfect diets and for those who smoke or spend any time with someone who does.

References
1) Hawkins, E.B.; Astaxanthin and Oxidative Stress; Natural Pharmacy, October 2003, pp. 20-21
2) Lorenz, R.T.; Astaxanthin, Nature’s Super Carotenoid; Bioastin® Technical Bulletin #062, Cyanotech Corporation, October 2000, pp.1-19
3) Lorenz, R.T.; Bioastin®, Nature’s Premier Astaxanthin Source; NatuRose™ Technical Bulletin #078; Cyanotech Corporation, October 2000, pp. 1-13
4) Naguib, Y.M.A.; Antioxidant Activities of Astaxanthin and Related Carotenoids, Journal of Agricultural Chemicals, 2000, 48, pp. 1150-1154
5) Kurashige, M. et. al.; Inhibition of oxidative injury of biological membranes by astaxanthin, Physiological Chemistry and Physics and Medical NMR, 1990, 22 (1), pp.27-38



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Vitamin C FAQ's
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Date: December 27, 2005 05:11 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Vitamin C FAQ's

Vitamin C FAQ's

What is Calcium Ascorbate?

Calcium Ascorbate is a buffered salt (mineral) form of the water-soluble antioxidant Vitamin C (ascorbic acid). Calcium is reacted with ascorbic acid to buffer the acidic nature of this vitamin, making it more gentle for the special needs of those who may have a sensitive gastrointestinal tract. The pH of this buffered mineral Ascorbate is approximately 6.8—7.4 as compared to ascorbic acid that is about a pH of 2.5. Calcium Ascorbate provides approximately 10% elemental calcium.

What does Calcium Ascorbate do?

Ascorbate (vitamin C) is a reducing sugar (has a reactive ene-diol structure) that is involved in biochemical processes such as hydroxylation of proline and lysine utilized in the formation of collagen and healthy connective tissue. A deficiency in Ascorbate results in a disease called scurvy which manifests as weakened collagen fibers, rotting teeth, delayed healing and open sores on the skin. Ascorbate is involved in many other vital functions such as the mobilization of iron, stimulation of immune system and as an anti-oxidant for scavenging of reactive free radicals.

Is this a necessary vitamin or can our bodies make enough to satisfy our needs?

Many plants and animals do not need to consume foods high in ascorbic acid to meet their need for Vitamin C because they are genetically programmed to produce enzymes that convert glucose into ascorbic acid. Unfortunately humans have only 3 of the 4 enzymes necessary for internal production of ascorbic acid, therefore we must satisfy our physical needs for this important vitamin through our intake of foods rich in vitamin C and/or take a good supplement.

What is the function of the Citrus Bioflavonoids?

Bioflavonoids are biologically active Flavonoid compounds found throughout the entire plant kingdom. Since the discovery of Flavonoids in 1936 when they were first isolated from lemons and called citrin and Vitamin P over 4,000 different types have been characterized. Though there are several forms of Bioflavonoids in the complex the predominant form is Hesperidin. These Flavonoids exhibit beneficial effects on capillary permeability and therefore support blood flow. They are antioxidants that work synergistically with Vitamin C as well as exhibiting anti-inflammatory activity.

Why are there color variations in your different Vitamin C products, and are they safe to take?

Most natural Vitamin C products vary in color from batch to batch and bottle to bottle. There are normally variations in the color of the raw material used during manufacturing, which is a normal occurrence. This is due to natural color variations in the source of the Vitamin C – generally, you will find C supplements to range in color from a light tan color to a light gray color.

Over the course of the shelf-life of a Vitamin C supplement, oxidation can cause a slight change in color, so you may find the light tan C-1000 you bought has changed to a darker tan six months later. This is a normal occurrence, and the product is safe to use up until the expiration date, and even beyond. NOW® is generally conservative with expiration dates, so a Vitamin C product is still safe after the date, it just may not be as effective due to oxidation.

Why does your Ester-C Complex say 625mg on the front of the label but list 500mg on the Supplement Facts panel? The key word is “complex”. Ester-C Complex is a combination of ascorbic acid (natural Vitamin C) and Calcium Ascorbate, which ultimately yields 500 total mg of Vitamin C. It is complexed with Calcium Ascorbate and other metabolites for greater absorption and faster utilization by your body. So the total complex is 625mg of Ester-C Complex, which yields 500mg of natural Vitamin C as ascorbic acid.

NOW Ester-C Pure Powder states the serving size is ½ teaspoon. How much Vitamin C am I getting with this serving size? ½ teaspoon of Ester-C Pure Powder is equivalent to 2000mg of natural Vitamin C and 250mg of Calcium.

Can I pour the powder in NOW® Vitamin C capsules into a liquid instead of swallowing the capsule? Many people do not want to or cannot swallow capsules, tablets or softgels, for various reasons. Encapsulated Vitamin C products from NOW® can be opened and dumped into a liquid for consumption. Juice or water is recommended if you choose this method. However, taking Vitamin C with water on an empty stomach is the recommended method of ingestion. We do not recommend trying this method with Vitamin C in tablet form, although you can grind or smash a tablet into powder form and add to water or juice. If you choose to do this, use a mortar and pestle for best results and minimal loss of product. Why go through the trouble when NOW® carries Vitamin C in a powdered form already. Save yourself time and trouble by ordering this form instead. Disclaimer: This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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Glucosamine & Chondroitin - JOINT HEALTH
TopPreviousNext

Date: December 22, 2005 09:30 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Glucosamine & Chondroitin - JOINT HEALTH

  • Supports Healthy Joint Structure and Function
  • Supports Mobility and Ease of Movement

References:
1) Balch, James F. et. al. ; Prescription For Nutritional Healing 3 rd rd rdPrescription Edition Edition ; Avery; Penguin Putnam; 2000
2) Benedikt, H.; Glycosaminoglycans And Derivatives For Treatment Of Arthritis; Chiropractic Products, May 1997, pp. 92-95
3) Reginster, Jean Yves et. al.; Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial; The Lancet, 2001, Vol. 357, No. 9252 4) Bassleer, C. et. al.; Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro; Osteoarthritis and Cartilage, 1998, 6, 427-434
5) Drovanti, A. et. al.; Therapeutic Activity of Oral Glucosamine Sulfate in Osteoarthritis: A Placebo-Controlled, Double-Blind Investigation; Clinical Therapeutics, Vol. 3, No. 4, 1980, pp. 260-272
6) Morreale, P. et. al.; Comparison of the Antiinfl ammatory Effi cacy of Chondroitin Sulfate and Diclofenac Sodium in Patients with Knee Osteoarthritis; Journal of Rheumatology, 1996, 23:8, pp. 1385- 1391



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7-Keto - Anti-Aging and Antioxidant Protection
TopPreviousNext

Date: December 18, 2005 09:44 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: 7-Keto - Anti-Aging and Antioxidant Protection

7-Keto

“Anti-Aging and Antioxidant Protection”

The Fountain of Youth Discovered in Wisconsin

It turns out that Ponce de Leon was looking in the wrong place for the fabled Fountain of Youth. It was recently discovered – in Wisconsin! And it turns out that the Fountain of Youth isn’t really a fountain – it’s a biological compound produced in our own bodies. This compound is extremely important for the growth and development of the human body, and, as the body’s production of this substance decreases with age, the signs of aging begin to appear – weight gain, wrinkled skin, loss of muscle, loss of cognitive function, and loss of libido.

This biological Fountain of Youth was discovered by Dr. Henry Lardy and associates at the Institute for Enzyme Research at the University of Wisconsin. It’s called 7-Keto™, a metabolite of a hormone produced by the adrenal glands called DHEA (dehydroepiandrosterone). Research on 7-Keto™ indicates that it may work through a number of pathways to combat the signs of aging. Helping the body maintain a healthy weight as we age greatly improves overall health and longevity and is one of the strongest benefits discovered for 7-Keto™ to date.

Unfortunately, because 7-Keto™ is a metabolite of DHEA, whose levels decline as we age, so to does this wonderful, natural bio-nutrient. Scientists originally looked to DHEA for improved cardiovascular vitality, and strengthened immune and brain function3. Researchers believed that declining DHEA so profoundly impacted our bodies that it could be partly responsible for the effects of aging. They hypothesized that supplementation with DHEA could sustain hormone levels and stave off many of the degenerative changes we collectively call aging. But there was a catch. Because DHEA is converted into sex hormones, people taking supplemental DHEA would sometimes experience the frightening, unwanted side effects associated with hormone supplementation.

In 1989, Dr. Lardy and his colleagues set out to solve the mystery of eliminating DHEA’s side effects by examining all of the constituents that make up DHEA. Ten long years of research unearthed hundreds of DHEA derivatives, which were developed and tested continuously, until one derivative rose above all the others – a metabolite that was incredibly bio-active and far more promising than any other substance they’d tested. That metabolite is 7-Keto™. 7-Keto™ outperformed DHEA and other metabolites in immune modulation, memory enhancement and thermogenesis and, more importantly, without any adverse side effects3.

The most significant benefit of 7-Keto™ supplementation is its ability to support healthy body weight. Obesity is a major contributing factor in a number of serious medical conditions. A recent study assessed the effectiveness of 7-Keto™ on weight loss and body fat loss. Participants were divided into two groups; one group received 100mg of 7-Keto™ twice daily and the other a placebo. Both groups exercised three times per week. At the end of the study, researchers noted a statistically significant reduction in body weight and body fat only in the 7-Keto™ group. Researchers concluded that 7-Keto™ was three times more effective than diet and exercise alone in promoting weight and fat loss1,2,7. Preliminary research also indicates that 7-Keto™ may support healthy immune and nervous systems. One study measured the effects of 7-Keto™ on memory function. Subjects were given a single dose of a substance that inhibits nerve cell communication and causes shortterm memory loss. Afterwards subjects were given a single dose of 7-Keto™. Results showed that 7-Keto completely reversed the memory impairment, suggesting that 7-Keto™ supports memory retention6.

Another study gauged 7-Keto™’s ability to support immune system function. Interleukin 2 (IL2) is a substance produced by T lymphocytes that causes an increase of disease fighting white blood cells. White blood cells were taken from healthy volunteers and introduced into a solution that contained 7-Keto™ for 24 hours. When the cultures were tested for heightened IL2 production. 7-Keto™ was shown to augment IL2 production by a statistically significant 68%4.

NOW® 7-Keto™ is a well-researched and patented form of this amazing product that’s supplied by the Humanetics Corporation. Humanetics 7-Keto™ has been proven safe and well-tolerated in doses up to 200mg5. Research is clear, the rate at which we age can be influenced by the diet and lifestyle choices we make. One very smart choice would clearly be adding NOW 7-Keto™ to your diet.

References

1) 7-Keto™: The Key to Healthy Aging – Scientific Support; Humanetics Corporation, 1999
2) Garbis, Spiro; 7-Keto™ DHEA; internal meta-analysis, 2000
3) Sahelian, Ray, M.D.; DHEA: A Practical Guide; Avery Publishing, 1996
4) Lardy, H. et.al. Dehydroepiandrosterone and 7-Keto™ DHEA Augment Interleukin 2 (IL2) Production by Human Lymphocytes In Vitro, 5th Conference on Retroviruses and Opportunistic Infections, February 1-5, 1998, Chicago, IL
5) Davidson, M.H. et. al. Clinical Safety and Endocrine Effects of 7-Keto™ DHEA; Presented at Experimental Biology 98 (Conference), April 19-22, 1998, San Francisco, CA
6) Shi, J. et. al. The Effect of 7-oxo- DHEA acetate on memory in young and old C57BL/6 mice; Steroids 65 (2000); 124-129
7) Colker, C. et. al. Double-Blind, Placebo-Controlled, Randomized Clinical Trial Evaluating the Effects of Exercise Plus 3-Acetyl- 7-oxo-dehydroepiandrosterone on Body Composition and the Endocrine System in Overweight Adults; Journal of Exercise Physiology online; Vol. 2, No. 4, October, 1999



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Super Cortisol Support Fact Sheet
TopPreviousNext

Date: December 08, 2005 07:04 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Super Cortisol Support Fact Sheet

Super Cortisol Support Fact Sheet

Neil E. Levin, CCN, DANLA 10/1/05

LIKELY USERS: People under a lot of stress; People who suffer from stress-related eating; People who may have metabolic syndrome (Syndrome X);

KEY INGREDIENTS: Relora®13, Rhodiola14-20, Reishi 21-24, Green Tea Extract25-32, Holy Basil, Ashwaganda, Banaba, Pantothenic Acid, Calcium Ascorbate, Magnesium, Lecithin, Chromium

MAIN PRODUCT FEATURES: NOW® Super Cortisol Support is an herbal and nutritional formula designed to support healthy adrenal function and maintain healthy cortisol levels. The adrenal glands help the body respond and adjust to stress generated from both internal and external forces. Under chronic stress, cortisol can be overproduced, resulting in weight gain and difficulty in managing healthy blood sugar levels. Super Cortisol Support combines adaptogenic herbs with Chromium, Corosolic Acid and Relora® to help the body manage the negative effects of stress such as abdominal obesity, overeating and low energy levels.

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES:

Reishi, Rhodiola, Ashwaganda, and Holy Basil support healthy energy levels throughout the day1-6. Reishi, Rhodiola, Ashwaganda, and Holy Basil support healthy immunity1-9. Along with Chromium, and Corosolic Acid, these herbs also help to support healthy serum glucose levels1-12. Relora® has been included in this formula to alleviate symptoms associated with stress such as irritability and nervous tension13.

This formula is recommended by Hyla Cass, MD.

This is the first Cortisol formula to use Relora®, a natural proprietary blend of a patented (U.S. Patent No. US 6,582,735) extract of Magnolia officinalis and a patent-pending extract from Phellodendron amurense. Relora® was developed as an ingredient for dietary supplements and functional foods that could be used in stress management and for stress-related appetite control. This patented blend of plant extracts is the result of screening more than fifty plant fractions from traditional plant medicines used around the world. Relora® has excellent stress management properties without causing sedation. Overweight adults may have excessive abdominal fat due to stress-related overeating. Relora® appears to maintain healthy hormone levels in stressed individuals and act as an aid in controlling weight and stress-related eating.33

SERVING SIZE & HOW TO TAKE IT: One capsule, two to three times a day.

COMPLEMENTARY PRODUCTS: Holy Basil, Green Tea, L-Theanine, Licorice Root, Vitamin C, Eleuthero Root, Pantothenic acid

CAUTIONS: None.

SPECIFIC: Some of these ingredients may support the body’s blood sugar controls, so people taking blood sugar medications should inform their physician before using Super Cortisol Support, and their glucose should be monitored when taking this formula so their medication strength can be modulated appropriately to avoid an overdose of medication. No side effects have been noted for this dosage of Relora®.

GENERAL: Pregnant and lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV (2000) Phytomedicine 7(2):85-89.
2. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H (2000) Phytomedicine 7(5):365-371.
3. Bhattacharya SK, Battacharya A, Sairam K, Ghosal S (2000) Phytomedicine 7(6):463-469.
4. Sembulingam K, Sembulingam P, Namasivayam A (1997) Indian J Physiol Pharmacol 41(2):139-143.
5. Archana R, Namasivayam A (2000) J Ethnopharmacol 73:81-85.
6. Lin Z-B, Zhang H-N (2004) Acta Pharmacol Sin 25(11):1387-1395.
7. Monograph (2002) Alt Med Rev 7(5):421-423.
8. Agarwal R, Divanay S, Patki P, Patwardhan B (1999) J Ethnopharmacol 67:27-35.
9. Archana R, Namasivayam A (2000) J Ethnopharmacol 73:81-85.
10. Vincent JB (2000) J Nutr 130:715-718. 11. Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YMA, Passwater R (2003) J Ethnopharmacol 81)1):115-117.
12. Lin Z-B, Zhang H-N (2004) Acta Pharmacol Sin 25(2):191-195.
13. Maruyama Y, Kuribara H, Morita M, Yuzurihara M, Weintraub ST (1998) J Nat Prod 61:135-138.
14. Brown RP, et al. American Botanical Council. Rhodiola rosea: a phytomedicinal overview. g/herbalgram/articleview.asp?a=2333.
15. Kelly GS. Rhodiola rosea: a possible plant adaptogen. Alt Med Rev 2001;3(6):293-302.
16. De Bock K, et al. Acute rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab 2004;14:298-307.
17. Shevtsov VA, et al. A randomized trial of two different doses of a SHR-5 rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;2-3(10):95-105.
18. Shugarman AE. Men’s Fitness, 2002. As reported on: LookSmart FindArticles. Energy pills that work: can these five supplements help unleash the muscle building power within you? ttp://findarticles.com/p/articles/mi_m1608/is_3_18/ai_83343009/
19. Earnest CP, et al. Effects of a commercial herbal-based formula on exercise performance in cyclists. Med Sci Sports Exerc 2004;36(3):504-9.
20. Wing SL, et al. Lack of effect of rhodiola or oxygenated water supplementation on hypoxemia and oxidative stress. Wilderness Env Med 2003;14(1):9-16.
21. Shu HY. Oriental Materia Medica: A Concise Guide. Palos Verdes, CA: Oriental Healing Arts Press, 1986, 640–1. 22. Kammatsuse K, Kajiware N, Hayashi K. Studies on Ganoderma lucidum: I. Efficacy against hypertension and side effects. Yakugaku Zasshi 1985;105:531–3.
23. Jin H, Zhang G, Cao X, et al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Nimmi H, Xiu RJ, Sawada T, Zheng C. (eds). Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science, 1996, 131–8.
24. 9. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995, 96–107.
25. Kono S, Shinchi K, Ikeda N, et al. Green tea consumption and serum lipid profiles: A cross-sectional study in Northern Kyushu, Japan. Prev Med 1992;21:526–31.
26. Yamaguchi Y, Hayashi M, Yamazoe H, et al. Preventive effects of green tea extract on lipid abnormalities in serum, liver and aorta of mice fed an atherogenic diet. Nip Yak Zas 1991;97:329–37.
27. Sagesaka-Mitane Y, Milwa M, Okada S. Platelet aggregation inhibitors in hot water extract of green tea. Chem Pharm Bull 1990;38:790–3.
28. Stensvold I, Tverdal A, Solvoll K, et al. Tea consumption. Relationship to cholesterol, blood pressure, and coronary and total mortality. Prev Med 1992;21:546–53.
29. Tsubono Y, Tsugane S. Green tea intake in relation to serum lipid levels in middle-aged Japanese men and women. Ann Epidemiol 1997;7:280–4.
30. Serafini M, Ghiselli A, Ferro-Luzzi A. In vivo antioxidant effect of green tea in man. Eur J Clin Nutr 1996;50:28–32.
31. Benzie IF, Szeto YT, Strain JJ, Tomlinson B. Consumption of green tea causes rapid increase in plasma antioxidant power in humans. Nutr Cancer 1999;34:83–7.
32. Sasazuki S, Komdama H, Yoshimasu K, et al. Relation between green tea consumption and severity of coronary atherosclerosis among Japanese men and women. Ann Epidemiol 2000;10:401–8.
33. Sufka KJ, et al. Anxiolytic properties of botanical extracts in the chick social separation-stress procedure.Psychopharmacology. 2001 Jan 1;153(2):219-24. PMID: 11205

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Nattokinase Fact Sheet
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Date: December 08, 2005 05:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Nattokinase Fact Sheet

Nattokinase Fact Sheet

Neil E. Levin, CCN, DANLA 8/8/05

LIKELY USERS: People seeking to support heart health and healthy circulation.1-6

KEY INGREDIENTS: Nattokinase, an enzyme

STRUCTURE/FUNCTION USE: Nattokinase is an enzyme isolated from Natto, a traditional Japanese fermented soy food. Natto has been consumed safely for thousands of years for its numerous health benefits. More recently, both clinical and non-clinical studies have demonstrated that Nattokinase supports heart health and promotes healthy circulation. Each serving of NOWR Nattokinase provides 2,000 FU (Fibrinolytic Units) to help keep already healthy levels of blood clotting factors within a normal range. 1-6

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: An assay of 2,000 FU (Fibrinolytic Units) is equivalent to 160 IU on the Urokinase assay. The FU assay measures Nattokinase activity by using the fibrin plate method and measuring the absorption of released low-molecular weight substances.7 NOW Nattokinase is made from non-GE (non-genetically engineered) bacteria (Bacillus subtilis var. Natto) grown on non-GE soybeans and standardized on a base of non-GE, corn-derived maltodextrin.

SERVING SIZE & HOW TO TAKE IT: Take one vegetarian Vcap once or twice a day between meals (without protein).

COMPLEMENTARY PRODUCTS: Vein SupremeTM, Tru-E Bio ComplexTM, Pycnogenol®, garlic, and cayenne

CAUTIONS: None.

SPECIFIC: People with blood coagulation disorders or who take anticoagulant (“blood thinning”) medications (including aspirin) should consult a physician before use. Do not take if prone to bleeding. Unlike some other brands, NOWR Nattokinase contains no Vitamin K (K1 or K2), which would enhance clotting.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S (1995) Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull 18(10):1387-1391
2. Sumi H, Hamada H, Nakanishi K, Hiratani H (1990) Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 84(3):139-143.
3. Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K (2003) Dietary Supplementation With Fermented Soybeans Suppresses Intimal Thickening. Nutrition 19:261-264.
4. Suzuki Y, Kondo K, Matsumoto Y, Zhao B-Q, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K (2003) Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 73:1289-1298.
5. Ito H, Suzuki T (2002) Effect of oral administration of nattokinase extract on blood mobility. Society of Analytical Bio-Sciences 25(4):1-5.
6. An Open Clinical Pilot Study to Evaluate the Safety and Efficacy of Natural Super Kinase as an Add-On Oral Fibrinolytic Agent to Low Molecular Weight Heparin and Anti-Platelets in Acute Ischaemic Stroke. (no authors listed) (2004)
7. Method: J of Agri Food Chem, Vol 48 (2000) P3, 210-213, 216



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OsteoBoron™ Fact Sheet
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Date: December 08, 2005 05:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: OsteoBoron™ Fact Sheet

OsteoBoron™ Fact Sheet

Neil E. Levin, CCN, DANLA 8/8/05

LIKELY USERS: People looking for joint support; People looking for bone density support; People who want to normalize Vitamin D levels

KEY INGREDIENTS: FruiteX-B™

STRUCTURE/FUNCTION CLAIMS: Boron is an important trace mineral for bone and joint health throughout life, as well as for the development and maintenance of healthy bone density. 1,2,4,6,8,9 NOW® OsteoBoron™ is a patented (US Patent # 5,962,049) complex of Boron and Fructose that is safe and more bioavailable than other forms of Boron. 3,7 NOW® OsteoBoron™ is a superior form of Boron that has been the subject of clinical studies demonstrating its efficacy in the support of healthy joints. 7,10 NOW® OsteoBoron™ has also been shown to be safer than other Boron supplements. 3,7

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES:

FruiteX-B™ is a patented ingredient that contains boron in a form that is chemically identical to the natural plant forms of boron found in food (Calcium Fructoborate). In human and animal studies this patented form of boron, taken at an amount equal or equivalent to 6 mg. per day, improved bone ash (bone minerals) and Vitamin D status in Vitamin D deficient subjects. In human studies, measurements of joint discomfort were dramatically reduced when taking this dosage for about 2 months. The dose used in most of these studies was equivalent to 2 capsules a day of NOW® OsteoBoron™, a form that has been shown to be biologically more beneficial than other forms of boron.11

SERVING SIZE & HOW TO TAKE IT: One vegetarian capsule twice a day, preferably at separate meals. This dose can be doubled for people with more severe deficiencies, though a physician should normally be consulted in such cases.

COMPLEMENTARY PRODUCTS: Vitamin D, Calcium, Magnesium, copper, Silica/silicon, natural sources of phytoestrogens (plant sourced), Ipriflavone, Bone Strength or Bone Calcium formulas

CAUTIONS: None.

SPECIFIC: Please note any supplements currently consumed which may also contain boron, such as multiple mineral or multiple vitamin formulas, and cut your serving size of NOW® OsteoBoron™ to compensate. People who eat a lot of produce, fruit and nuts may also get a substantial amount from their food and may want to reduce their servings of NOW® OsteoBoron™ accordingly. NOW® OsteoBoron™ is safer (has less toxicity) than boron citrate. Boron may buffer body levels of estrogen, so women at risk from high estrogen should consult a physician before using NOW® OsteoBoron™, even though this problem has not been noted for food source borons.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Shils ME, Olson JA, Shike M (eds.) (1994) Modern Nutrition in Health and Disease, Eighth Edition. Chapters 20-26, 28, 30. Lea & Febiger Philadelphia.
2. Chang EB, Sitrin MD, Black DD (1996) Gastrointestinal, Hepatobiliary, and Nutritional Physiology. Chapter 9, Absorption of Water-Soluble Vitamins and Minerals. Lippincott-Ravin, Philadelpia
3. Miljkovic D (1999) Boron and carbohydrate complexes and uses thereof. U.S. Patent # 5,962,049.
4. Neilson FH (2000) The Emergence of Boron as Nutritionally Important Throughout the Life Cycle. Nutrition 16(7/8):512-514.
5. Schaafsma A, de Vries PJ, Saris WH (2001) Delay of natural bone loss by higher intakes of specific minerals and vitamins. Crit Rev Food Sci Nutr 41(4):225-249.
6. Devirian TA, Volpe SL (2003) The physiological effects of dietary boron. Crit Rev Food Sci Nutr 43(2):219-213.
7. Miljkovic ND, Miljkovic DA, Ercegan GM (2002) Osteoarthritis and Calcium Fructoborate Supplementation: An Open-Label Study. FutureCeuticals Internal Study.
8. Sheng MH-C, Taper J, Veit H, Qian H, Ritchey SJ, Lau K-H W (2001) Dietary Boron Supplementation Enhanced the Action of Estrogen, But Not that of Parathyroid Hormone, to Improve Trabecular Bone Quality in Ovariectomized Rats. Biol Trace Elem Res 81:29-45.
9. Naghii MR, Samman S (1997) The effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjects. Biol Trace Elem Res 56(3):273-286.
10. Travers RL, Rennie GC, Newnham RE (1990) Boron and Arthritis: The Results of a Double-Blind Pilot Study. Journal of Nutritional Medicine 1:127-132.
11. Periasamy M, et al. (2001) J Org Chem, 66, 3328-3833

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Tru-E Bio Complex
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Date: December 08, 2005 04:58 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Tru-E Bio Complex

Tru-E Bio Complex TM

Neil E. Levin, CCN, DANLA 7/27/05

LIKELY USERS: Most Americans are deficient in Vitamin E 8,9,10; People needing superior antioxidant protection3,5,6; People needing cardiovascular or cholesterol support27,30,31; People needing nervous system support7; Those wanting healthier skin6; Diabetics may need additional Vitamin E24 KEY INGREDIENTS: Tocopherols from IP-Preserved, non-GMO Soy; Tocotrienols and tocopherols from non-GMO virgin palm; Tocotrienols from non-GMO annatto seed

MAIN PRODUCT FEATURES: NOW Tru-E Bio ComplexTM is a unique biologically balanced, patent-pending formula designed to provide optimal Vitamin E activity. This product features 100% natural, Non-Genetically Modified sources of all 8 isomers (forms) of the Vitamin E “family” in ratios similar to what is found in a healthy diet. It provides the superior benefits of foodsource Vitamin E versus those obtained from traditional E supplements.

NOW® Tru-E Bio ComplexTM has been carefully blended to supply high levels of the natural gamma and delta “desmethyl” forms of both tocopherols and tocotrienols. This is important because recent research indicates that these isomers work best as a team to quench the lipid and nitrogen free radicals known to cause injury to cells and tissues. This product supports a healthy cardiovascular system, youthful skin and nervous system function with potent antioxidants. This science-based natural Vitamin E supplement is unlike any other and the first to combine all of these benefits in one convenient non-GMO formula! 25-32

Recent research indicates that these isomers work best as a team to quench the lipid and nitrogen free radicals known to cause injury to cells and tissues.1-4, 25-32

This product supports a healthy cardiovascular system, youthful skin and nervous system function with potent antioxidants.1,4-7

Levels of Vitamin E above 100 IU daily are associated with decreased risk of coronary heart disease and certain types of cellular disorders, as well as enhancement of immune function. These vitamin E intakes are considerably above levels obtainable from diet alone. 11,12,13

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES:

This is a product that is Patent Pending, based on months of research into optimal forms, potencies and ratios of the 8 isomers of natural Vitamin E. All of the Vitamin E formulas currently on the market use potencies of tocopherols that are very dissimilar to what is found in a healthy diet, with either too low or too high amounts of gamma and alpha tocopherols for a good balance. Some do not even include tocotrienols.

All of the Vitamin E formulas on the market that do contain a mixture of tocopherols and tocotrienols tend to use either 400 IU or 100 IU of alpha tocopherol, some as little as 50-60 IU, combined with varying doses of gamma tocopherol. We have reduced the alpha tocopherol from the standard 400 IU per capsule to 200 IU, allowing more gamma tocopherol in the capsule to follow the typical ratio in a healthy diet. Other brands either cut the alpha tocopherol too low (to keep the gamma tocopherol at a good level) or else cut the gamma and other tocopherols too low (to keep the alpha tocopherol at 400 IU).

Special care was used to maintain a certain ratio of tocopherols and of tocotrienols that is unique and from natural sources. Our formula is also unique in mixing sources of tocotrienols to achieve our desired balance, whereas other formulas include only one source, despite the dissimilarity of the mixture to what is found in a healthy, varied diet.

Other formulas use either Vitamin E derived from genetically engineered soybeans and/or add soybean oil from similar sources as a base. NOW uses expensive non-GMO sources, the first formula to do so, with no soybean oil added. This enhances the quality of our product compared to every other formula on the market.

We use the expensive virgin palm oil rather than the cheap palm distillates because it is un-denatured and contributes additional, valuable oil nutrients such as CoQ10, Squalene and Sterols. Also, much of the clinical research done on tocotrienols was done using virgin palm oil sources 32

Natural Vitamin E is more effective than synthetic Vitamin E.14 - 23

SERVING SIZE & HOW TO TAKE IT: One or two capsules per day, preferably with meal(s). Oils enhance the absorption of Vitamin E. Concentrated fiber supplements may decrease the absorption of Vitamin E, so it is best not to take both at the same meal.

SYNERGISTS: Antioxidants (Alpha Lipoic Acid, Vitamin C Complex, Pine or Grapeseed Extracts, VitaBerry Plus+, CoQ10, etc.), Plant Sterols, Fish Oil, Flaxseed Oil, GliSODin, EGCg Green Tea Extract, Lecithin, Nuts and Seeds

CAUTIONS: None.

SPECIFIC: Aspirin and blood thinners should not be taken with Vitamin E without physician’s approval. Many other pharmaceutical drugs deplete Vitamin E, adding to the likelihood that a person will be deficient.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

REFERENCES:

1. Jiang Q, Christen S, Shigenaga MK, Ames BN (2001) g-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 74:714-722.
2. Schneider C (2005) Chemistry and biology of vitamin E. Mol Nutr Food Res 49(1):7-30.
3. Pfluger P, Kluth D, Landes N, Bumke-Vogt C, Brigelius-Flohe R (2004) Vitamin E: underestimated as an antioxidant. Redox Rep 9(5):249-254.
4. Liu M, Wallin R, Saldeen (2002) Effect of mixed tocopherols on ecNOS, SOD, and PKC in leukocytes in human subjects. Nutr Res 22:1253-1263.
5. Saldeen T, Li D, Mehta JL (1999) Differential Effects of a- and g-Tocopherol on Low-Density Lipoprotein Oxidation, Superoxide Activity, Platelet Aggregation and Arterial Thrombogenesis. J Am Coll Cardiol 34:1208-1215.
6. "Packer L, Valacchi G. (2002) Antioxidants and the response of skin to oxidative stress: vitamin E as a key indicator. Skin Pharmacol Appl Skin Physiol 15(5):282-90."
7. Sen CK, Khanna S, Roy S. (2004) Tocotrienol: the natural vitamin E to defend the nervous system? Ann N Y Acad Sci 1031:127-42.
8. Dial S, Eitenmiller RR. 1995. Tocopherols and tocotrienols in key foods in the U.S. diet. In: Ong ASH, Niki E, Packer L, eds. Nutrition, Lipids, Health, and Disease. Champaign, IL: AOCS Press. Pp. 327–342.
9. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000). Institute of Medicine
10. JASPREET K.C. AHUJA, JOSEPH D. GOLDMAN, and ALANNA J. MOSHFEGH. Current Status of Vitamin E Nutriture. Ann NY Acad Sci 2004 1031: 387-390.
11. Bauernfeind, J. Tocopherols in Foods. In: Vitamin E: A Comprehensive Treatise. Marcel Dekker, Inc., New York and Basel, pp. 99-167, 1980.
12. Horwitt, M.K. The Promotion of Vitamin E. J. Nutr. 116:1371-1377, 1986.
13. Weber, P., Bendich, A. and Machlin, L.J. Vitamin E and Human Health: Rationale for Determining Recommended Intake Levels. Nutrition 13:450-460, 1997.
14. Acuff RV et al. Am. J. Clin. Nutr. 1998;67:459-64
15. Acuff RV et al, Am. J. Clin. Nutr. 1994, 60:397-402
16. Behrens, W.A. and Madere, R. Tissue Discrimination between Dietary RRR-Alpha- and All-Rac-Alpha-Tocopherols in Rats. J. Nutr. 121:454-459, 1991.
17. Burton G et al, Am. J. Clin. Nutr. 1998,67:669-84
18. Ferslew, K.E., Acuff, R.V., Daigneault, E.A., Woolley, T.W. and Stanton, P.E. Pharmacokinetics and Bioavailability of the RRR and All Racemic Stereoisomers of Alpha-Tocopherol in Humans after Single Oral Administration. J. Clin. Pharmacol. 33:84-88, 1993.
19. Horwitt, M.K. The Promotion of Vitamin E. J. Nutr. 116:1371-1377, 1986.
20. Ogihara, T., Nishida, Y., Miki, M. and Mino, M. Comparative Changes in Plasma and RBC Alpha-Tocopherol after Administration of dl-Alpha-Tocopheryl Acetate and d-Alpha-Tocopherol. J. Nutr. Sci. Vitaminol. 31:169-177, 1985.
21. Traber M et al, FEBS Letters 1998,437:145-148
22. Traber MG, et al. J Lipid Res. 1990,31(4):675-85
23. Weiser, H. and Vecchi, M. Stereoisomers of Alpha-Tocopheryl Acetate. II. Biopotencies of All Eight Stereoisomers, Individually or in Mixtures, as Determined by Rat Resorption-Gestation Tests. Internat. J. Vit. Nutr. Res. 52:351-370, 1982.
24. Polidori MC, Mecocci P, Stahl W, et al. Plasma levels of lipophilic antioxidants in very old patients with type 2 diabetes. Diabetes Metab Res Rev 2000;16:15–9.
25. Cooney RV, Franke AA, Harwood PJ, Hatch-Pigott V, Custer LJ, and Mordan LJ. gamma-Tocopherol Detoxification of Nitrogen Dioxide: Superiority to alpha-Tocopherol. PNAS 1993; 90: 1771-1775.
26. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggarwal NT, Scherr PA. Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am J Clin Nutr. 2005 Feb;81(2):508-14. PMID: 15699242
27. Inokuchi H, Hirokane H, Tsuzuki T, Nakagawa K, Igarashi M, Miyazawa T. Anti-angiogenic activity of tocotrienol. Biosci Biotechnol Biochem. 2003 Jul;67(7):1623-7. PMID: 12913317
28. Kline K, Yu w, Sander BG, et al. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. (1999), Nutr Cancer, 33 : pp : 26 – 32
29. The Chicago Health and Aging Project, Martha Clare Morris, Denis A Evans, Christine C Tangney, Julia L Bienias, Robert S Wilson, Neelum T Aggarwal and Paul A Scherr. Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. American Journal of Clinical Nutrition, Vol. 81, No. 2, 508-514, February 2005
30. Parker RA, Pearce BC, Clark RW, Gordon DA, Wright JJ. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem. 1993 May 25;268(15):11230-8. PMID: 8388388
31. Pearce BC, Parker RA, Deason ME, Qureshi AA, Wright JJ. Hypocholesterolemic activity of synthetic and natural tocotrienols. J Med Chem. 1992 Oct 2;35(20):3595-606. PMID: 1433170
32. Soelaiman IN, Ahmad NS, Khalid BA. Palm oil tocotrienol mixture is better than alpha-tocopherol acetate in protecting bones against free-radical induced elevation of bone-resorbing cytokines. Asia Pac J Clin Nutr. 2004 Aug;13(Suppl):



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Psyllium Husk Fiber Fact Sheet
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Date: December 08, 2005 04:28 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Psyllium Husk Fiber Fact Sheet

Psyllium Husk Fiber Fact Sheet

Neil E. Levin, CCN, DANLA 8/1/05

LIKELY USERS: People with cholesterol or cardiovascular concerns.1-2 People wanting to increase fiber in their diet3-9

KEY INGREDIENTS: Psyllium Husk Powder, natural flavor

MAIN PRODUCT FEATURES: Psyllium is a true dietary fiber, even though it is classified by some as a laxative or mucilaginous fiber, and is a convenient way to increase intake of dietary fiber because of its high mucilage content. This bulking agent swells considerably when added to liquid, which can help to increase gastrointestinal transit time. This bulking action and increased transit time can play an important role in maintaining healthy gastrointestinal function.3-9 The FDA allows a health claim for products like psyllium husk that provide significant amounts of soluble fiber: Diets low in saturated fat and cholesterol that include 1.7 grams of soluble fiber per day from psyllium husk may reduce the risk of heart disease. One serving of NOW Psyllium Husk Fiber - Orange Flavored provides 2 grams of this soluble fiber.1-2

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: This product has been tested by an independent laboratory to assay the fiber content. This is a vegetarian/vegan product.

SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, mix 1 heaping teaspoon into at least 12 oz. of water or juice and consume immediately. Be sure to drink plenty of additional fluids throughout the day. Start with smaller amounts and gradually increase over several weeks.

COMPLEMENTARY PRODUCTS:

For GI tract: Triphala, Detox Support, Probiotics, FOS, and healthy oils (fish, flax, olive, virgin coconut, virgin macadamia)

For cardiovascular health: Hawthorn extract, Tru-E Bio Complex (new September 2005), Heart Support, Heart Renew, Cholesterol Support, Cholestatin, Policosanol. Red Yeast Rice CAUTIONS: None.

SPECIFIC: Do not use if you have a bowel obstruction or an ulcer. If you have chronic constipation, diabetes or are obese a physician should monitor the use of this dietary supplement. Side effects are possible with any dietary supplement. This dietary supplement may cause gastrointestinal pain, flatulence and abdominal pain. Tell your doctor if these side effects become severe or do not go away.

NOTICE: This food should be eaten with at least a full glass of liquid. Eating this product without enough liquid may cause choking. Do not eat this product if your have difficulty in swallowing.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. [Code of Federal Regulations] [Title 21, Volume 2] [Revised as of April 1, 2002]
2. Jenkins DJ, Kendall CW, Vuksan V, Vidgen E, Parker T, Faulkner D, et al. Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. Am J Clin Nutr. May2002;75(5):834-839.
3. McRorie JW, et al. Psyllium is superior to docusate sodium for treatment of chronic constipation. Aliment Pharmacol Ther. May1998;12(5):491-7.
4. Washington N, et al. Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation. Am J Clin Nutr. Feb1998;67(2):317-21.
5. Leib MS. Treatment of chronic idiopathic large-bowel diarrhea in dogs with a highly digestible diet and soluble fiber: a retrospective review of 37 cases. J Vet Intern Med. Jan2000;14(1):27-32.
6. Schwesinger WH, et al. Soluble dietary fiber protects against cholesterol gallstone formation. Am J Surg. Apr1999;177(4):307-10.
7. Davidson MH, et al. Long-term effects of consuming foods containing psyllium seed husk on serum lipids in subjects with hypercholesterolemia. Am J Clin Nutr. Mar1998;67(3):367-76.
8. Jalihal A, et al. Ispaghula therapy in irritable bowel syndrome: improvement in overall well-being is related to reduction in bowel dissatisfaction. J Gastroenterol Hepatol. Sep1990;5(5):507-13.
9. Obata K, et al. Dietary fiber, psyllium, attenuates salt-accelerated hypertension in stroke-prone spontaneously hypertensive rats. J Hypertens. Dec1998;16(12 Pt 2):1959-64.



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Butterbur Extract Fact Sheet
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Date: December 08, 2005 04:22 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Butterbur Extract Fact Sheet

Butterbur Extract Fact Sheet

Neil E. Levin, CCN, DANLA 8/1/05

LIKELY USERS: People wanting to support healthy blood flow to the brain and healthy neurological function 1-6,10 Those maintaining normal seasonal immune responses 7-10

KEY INGREDIENTS: 75 mg of Guaranteed Potency Butterbur Root (Petasites hybridus) Extract, min. 15 Sesquiterpenes as Petasines; 200 mg of Feverfew Leaf (Tanacetum parthenium) min. 0.4% Parthenolides

MAIN PRODUCT FEATURES: Butterbur (Petasites hybridus) is a native shrub of Europe, North America, and Asia that has been used by herbalists for centuries. Modern scientific studies have demonstrated that Butterbur supports healthy blood flow to the brain and healthy neurological function.1-6, 10 In addition, Butterbur may help to maintain balanced seasonal immune responses.7-10 In a synergistic base of guaranteed potency Feverfew leaf.11-26

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: NOW Butterbur is free of harmful levels of Pyrrolizidine Alkaloids (PAs), the undesirable compounds naturally found in Butterbur, so it is safe to use regularly.

SERVING SIZE & HOW TO TAKE IT: Take one VCap one to three times per day, or as directed by your physician.

COMPLEMENTARY PRODUCTS: Magnesium, Ulcetrol, B-2, B-12, Fish Oil (EPA, DHA), SAM-e, Ginger, Ginkgo Biloba

CAUTIONS: None.

SPECIFIC: Do not discontinue use abruptly; taper off use if discontinuing. Discontinue use at least 14 days before surgery or oral surgery. Use with caution if you have ragweed allergies or blood disorders and let your physician know that you plan to use it before you take it. May be contraindicated for pregnant women.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:

1. Diener HC, Rahlfs VW, Danesch U (2004) The First Placebo-Controlled Trial of a Special Butterbur Root Exract for the Preventio of Migraine: Reanalysis of Efficacy Criteria. Eur Neurol 51:89-97.
2. Lipton RB, Gobel H, Einhaupl KM, Wilks K, Mauskop A (2004) Petasites hybridus root (butterbur) is an effective preventative treatment for migraine. Neurology 63:2240-2244.
3. Pothmann R, Danesch U (2005) Migraine Preventiuon in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 45:196-203.
4. Rapaport AM, Bigal ME (2004) Perventive migraine therapy: what is new. Neurol Sci 25:S177-S185.
5. Wu SN, Chen H, Lin YL (2003) The mechanism of inhibitory actions of S-petasin, a sequiterpene of Petasites formosanus, on L-type calcium current in NG108-15 neuronal cells. Planta Med 69(2):118-124.
6. Wang G-J, Wu X-C, Lin Y-L, Ren J, Shum AY-C, Wu Y-Y, Chen C-F (2002) Ca2+ channel blockin effect of iso-S-petasin in rat aoritic smooth muscle cells. Eur J Pharmacol 445(3):239-45.
7. Lee DKC, Carstairs IJ, Haggart K, Jackson CM, Currie GP, Lipworth BJ (2003) Butterbur, a herbal remedy, attenuates adenosine monophosphate induced nasal responsiveness in seasonal allergic rhinitis. Clin Exp Allergy 33:882-886.
8. Lee DKC, Haggart K, Robb FM, Lipworth BJ (2004) Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids. Clin Exp Allergy 34:110-114.
9. Lee DKC, Gray RD, Robb FM, Fujihara S, Lipworth BJ (2004) A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Clin Exp Allergy 34:646-649.
10. (No Author) (2001) Petasites hybridus (Butterbur). Alt Med Rev 6(2):207-209.
11. Hayes NA, et al. The Activity of Compounds Extracted from Feverfew on Histamine Release from Rat Mast Cells. J Pharm Pharmacol. Jun1987;39(6):466-70.
12. 2 Groenewegen WA, et al. A Comparison of the Effects of an Extract of Feverfew and Parthenolide, a Component of Feverfew, on Human Platelet Activity In-vitro. J Pharm Pharmacol. 1990;42(8):553-57.
13 Capasso F. The Effect of An Aqueous Extract of Tanacetum parthenium L. on Arachidonic Acid Metabolism by Rat Peritoneal Leucocytes. J Pharm Pharmacol. Jan1986;38(1):71-72.
14. 4 Bejar E. Parthenolide Inhibits the Contractile Responses of Rat Stomach Fundus to Fenfluramine and Dextroamphetamine but not Serotonin. J Ethnopharmacol. Jan1996;50(1):1-12.
15. 5 Prusinski A, Durko A, Niczyporuk-Turek A. [Feverfew as a Prophylactic Treatment of Migraine]. Neurol Neurochir Pol. 1999;33(Suppl 5):89-95.
16. 6 Barsby RW, et al. Feverfew Extracts and Parthenolide Irreversibly Inhibit Vascular Responses of the Rabbit Aorta. J Pharm Pharmacol. Sep1992;44(9):737-40.
17. 7 Pittler MH, Vogler BK, Ernst E. Feverfew for Preventing Migraine (Cochrane Review). Cochrane Database Syst Rev. 2000;(3):CD002286.
18. 8 Pattrick M, et al. Feverfew in Rheumatoid Arthritis: A Double-blind, Placebo Controlled Study. Ann Rheum Dis. 1989;48:547-49.
19. 9 Makheja AM, et al. A Platelet Phospholipase Inhibitor from the Medicinal Herb Feverfew (Tanacetum parthenium). Prostaglandin Leukotri Med. 1982;8:653-60. 20. 12 Drug Identification Number Notification. Drugs Directorate, Therapeutic Products Division, Health Protection Branch, Health Canada . Ottawa , Canada
20. 12 Drug Identification Number Notification. Drugs Directorate, Therapeutic Products Division, Health Protection Branch, Health Canada. Ottawa, Canada.
21. 14 Newall CA, et al. Herbal Medicines: A Guide for Health Care Professionals. London: The Pharmaceutical Press; 1996:119-21.
22. 15 PDR for Herbal Medicines, 2nd ed. Montvale , NJ: Medical Economics Company; 2000:307.
23. 16 Pribitkin ED. Herbal therapy: what every facial plastic surgeon must know. Arch Facial Plast Surg. Apr2001;3(2): 127-32.
24. 17 Schmidt RJ. Plant dermatitis. Compasitae. Clin Dermatol. Apr1986;4(2):46-61.
25. 18 Heck AM, et al. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. Jul2000;57(13): 1221-7.
26. 19 Newall CA, et al. Herbal Medicines: A Guide for Health Care Professionals. London : The Pharmaceutical Press; 1996:119-21.



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Carnitine Creatinate
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Date: December 08, 2005 03:33 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Carnitine Creatinate

Carnitine Creatinate

Neil E. Levin, CCN, DANLA 6/30/05

LIKELY USERS: Athletes, Bodybuilders, Dieters, People who consume a lot of fat, People needing cardiovascular support (energy for the heart), People who need quick energy, especially for fast muscle response, People with muscle wasting problems (including the elderly), Weightlifters

KEY INGREDIENTS: L-Carnitine and Creatine Monohydrate

MAIN PRODUCT FEATURES: Carnitine Creatinate Monohydrate is a specialized form of Creatine bonded to L-Carnitine. Creatine is a compound natural to the human body that aids in the regeneration of ATP, the chemical energy used by muscle tissue. During exercise, large quantities of creatine are irreversibly consumed. Clinical studies have shown that oral supplementation with Creatine can increase the amount of Creatine available in muscles for ATP production. L-Carnitine is an amino acid that is necessary for the transfer of fatty acids into the fat-burning parts of the cell, facilitating energy production from fat. The combination of these two compounds can produce a synergistic effect, making NOW® Carnitine Creatinate an ideal energy supplement.

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: Carnitine and Creatinate Monohydrate is a patented ingredient that has been the subject of research studies. It is supported by the scientific staff in the laboratories of both NOW Foods and the raw material supplier, both of which have a mutual interest in protecting the integrity and efficacy of this product. Protected by U.S. Patent No. 5,994,581 (L-Carnitine Creatinate Monohydrate).

Look at the price: this is a better way to buy both supplements than purchasing them separately.

This formula is suitable for vegetarians and is offered in both tablet and powder forms.

SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, every two tablets provide 1,000 mg. (one gram) each of both L-Carnitine and Creatine Monohydrate. Or one teaspoon provides 1,150 mg.) each of both L-Carnitine and Creatine Monohydrate. Take one or more servings per day with a carbohydrate source, such as fruit juice or sports drinks.

COMPLEMENTARY PRODUCTS: CoQ10, carbohydrates, B-Complex vitamins, chromium, vanadium, Hawthorn leaf and flower extract, protein supplements. Adaptogenic herbs: ginsengs, Eleuthero, Rhodiola, Maca, Ashwaganda, licorice root

CAUTIONS: none.

PRODUCT SPECIFIC: This product is very sensitive to moisture. Please keep in the original packaging or in a moisture resistant container. Do not take more than 20 grams per day. Discontinue use if cramps of stomach upset occur, especially if taking large doses. Do not take if kidney disease is present. Do not use large doses of caffeine with creatine, as it may increase the possibility of muscle cramping.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems.

Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

Fang S-M (1998) Carnitine Creatinate. U.S. Patent 5,994,581.

L-CARNITINE:

Beers MH, Berkow R (eds). The Merck Manual of Diagnosis and Therapy, 17th ed. Whitehouse Station, NJ: Merck and Co., Inc, 1999, 881-3.

Broquist HP (1994) Carnitine, in Modern Nutrition in Health and Disease, 8th ed., Shils ME, Olson JA, Shike M (eds.) Lea & Febiger, Philadelphia, pp. 459-465. Casey A, Greenhoff PL (2000) Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance? Am J Clin Nutr 72(suppl):607S-17S. Columbani P, Wenk C, Kunz I, et al. Effect of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: a double blind crossover field study. Eur J Appl Physiol 1996;73:434-9.

Dal Negro R, Pomari G, Zoccatelli O, Turco P. L-carnitine and rehabilitative respiratory physiokinesitherapy: metabolic and ventilatory response in chronic respiratory insufficiency. Int J Clin Pharmacol Ther Toxicol 1986;24:453-6.

Dal Negro R, Turco P, Pomari C, De Conti F. Effects of L-carnitine on physical performance in chronic respiratory insufficiency. Int J Clin Pharmacol Ther Toxicol 1988;26:269-72.

Del Favero A. Carnitine and gangliosides. Lancet 1988;2:337 [letter].

Dipalma JR. Carnitine deficiency. Am Fam Physician 1988;38:243–51.

Digiesi V, Palchetti R, Cantini F. The benefits of L-carnitine in essential arterial hypertension. Minerva Med 1989;80:227-31.

Giamberardino MA, Dragani L, Valente R, et al. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. Int J Sports Med 1996;17:320-4.

Green RE, Levine AM, Gunning MJ. The effect of L-carnitine supplementation on lean body mass in male amateur body builders. J Am Diet Assoc 1997;(suppl):A-72.

Harris RC, Soderlund K, Hultman E (1992) Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci 83(3):367-374.

Kendler BS. Carnitine: an overview of its role in preventive medicine. Prev Med 1986;15:373–90.

Kobayashi A, Masumura Y, Yamazaki N. L-carnitine treatment for congestive heart failure—experimental and clinical study. Jpn Circ J 1992;56:86–94.

Murray MT. The many benefits of carnitine. Am J Natural Med 1996;3:6-14 [review].

Tamamogullari N, Silig Y, Icagasioglu S, Atalay A. Carnitine deficiency in diabetes mellitus complications. J Diabetes Complications 1999;13:251–3.

Yesilipek MA, Hazar V, Yegin O. L-Carnitine treatment in beta thalassemia major. Acta Haematol 1998;100:162-3. CREATINE MONOHYDRATE: Almada A, Mitchell T, Earnest C. Impact of chronic creatine supplementation on serum enzyme concentrations. FASEB J 1996;10:4567.

Becque MD, Lochmann JD, Melrose DR. Effects of oral creatine supplementation on muscular strength and body composition. Med Sci Sports Exerc 2000;32:654-8.

Casey A, Constantin-Teodosiu D, Howell S, et al. Creatine supplementation favorably affects performance and muscle metabolism during maximal intensity exercise in humans. Am J Physiol 1996;271:E31-E7.

Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci 1996;91:113-8.

Earnest C, Almada A, Mitchell T. Influence of chronic creatine supplementation on hepatorenal function. FASEB J 1996;10:4588.

Earnest CP, Snell PG, Rodriguez R, et al. The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol Scand 1995;153:207-9.

Felber S, Skladal D, Wyss M, et al. Oral creatine supplementation in Duchenne muscular dystrophy: a clinical and 31P magnetic resonance spectroscopy study. Neurol Res 2000;22:145-50.

Feldman EB. Creatine: a dietary supplement and ergogenic aid. Nutr Rev 1999;57:45–50.

Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in man. Am J Physiol 1996;271:E821–6.

Green AL, Simpson EJ, Littlewood JJ, et al. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiol Scand 1996;158:195-202.

Greenhaff PL. Creatine and its application as an ergogenic aid. Int J Sport Nutr 1995;5:94-101.

Greenhaff PL. The nutritional biochemistry of creatine. J Nutr Biochem 1997;8:610-8 [review].

Greenhaff PL, Bodin K, Soderlund K, et al. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am J Physiol 1994;266:E725-30.

Greenhaff PL, Casey A, Short AH, et al. Influence of oral creatine supplementation on muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci 1993;84:565-71.

Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci 1992;83:367-74.

Hultman E, Soderlund K, Timmons J, et al. Muscle creatine loading in man. J Appl Physiol 1996;81:232–7.

Juhn MS, O’Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999;99:593–5.

Kreider RB, Ferreira M, Wilson M, et al. Effects of creatine supplementation on body composition, strength, and sprint performance. Med Sci Sports Exerc 1998;30:73-82.

Poortmans JR, Auquier H. Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men. Eur J Appl Physiol Occup Physiol 1997;76:566–7.

Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108–10.

Pritchard NR, Kaira PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252–3 [letter].

Sewell DA, Robinson TM, Casey A, et al. The effect of acute dietary creatine supplementation upon indices of renal, hepatic and haematological function in human subjects. Proc Nutr Soc 1998;57:17A.

Silber ML. Scientific facts behind creatine monohydrate as a sports nutrition supplement. J Sports Med Phys Fitness 1999;39:179–88 [review].

Sipila I, Rapola J, Simell O, et al. Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. N Engl J Med 1981;304:867-70.

Stone MH, Sanborn K, Smith LL, et al. Effects of in-season (5-weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. Int J Sport Nutr 1999;9:146-65.

Stout JR, Eckerson J, Noonan D, et al. The effects of a supplement designed to augment creatine uptake on exercise performance and fat-free mass in football players. Med Sci Sports Exerc 1997;29:S251.

Tarnopolsky MA. Potential benefits of creatine monohydrate supplementation in the elderly. Curr Opin Clin Nutr Metab Care 2000;3:497-502 [review].

Tarnopolsky M, Martin J. Creatine monohydrate increases strength in patients with neuromuscular disease. Neurology 1999;52:854-7.

Tarnopolsky MA, Roy BD, MacDonald JR. A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve 1997;20:1502-9.

Toler SM. Creatine is an ergogen for anaerobic exercise. Nutr Rev 1997;55:21-5 [review].

Vandenberghe K, Gills N, Van Leemputte M, et al. Caffeine counteracts the ergogenic action of muscle creatine loading. J Appl Physiol 1996;80:452–7.

Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol 1997;83:2055-63.

Walter MC, Lochmuller H, Reilich P, Klopstock T, Huber R, Hartard M, Hennig M, Pongratz D, Muller-Felber W. Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study. Neurology. 2000 May 9;54(9):1848-50. PMID: 10802796

Walter MC, Reilich P, Lochmuller H, Kohnen R, Schlotter B, Hautmann H, Dunkl E, Pongratz D, Muller-Felber W. Creatine monohydrate in myotonic dystrophy: a double-blind, placebo-controlled clinical study. J Neurol. 2002 Dec;249(12):1717-22. PMID: 12529796



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Vitanet ®

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AHCC® Fact Sheet - from Now Foods.
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Date: December 08, 2005 10:20 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: AHCC® Fact Sheet - from Now Foods.

AHCC® Fact Sheet

Neil E. Levin, CCN, DANLA 6/30/05

LIKELY USERS: People needing increased activity of their Natural Killer cells; People seeking improved immune system response; People with a need for tissue repair; People with oxidative challenges; People seeking to increase liver function People defying aging or with a need to improve cellular integrity.

KEY INGREDIENTS: AHCC® (Active Hexose Correlated Compound)

MAIN PRODUCT FEATURES: AHCC® is a proprietary extract produced from specially cultivated and hybridized mushrooms. According to extensive research in humans, as well as numerous non-clinical studies, AHCC®supports immune system function through its effects on macrophages and NK (Natural Killer) Cells. NK cells and the intercellular mediators they produce are critical for the maintenance of healthy cell cycle function. AHCCR® has also been shown possess antioxidant properties, and supports healthy liver function.

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: AHCC® (Active Hexose Correlated Compound) is a patented ingredient that has been the subject of research studies. It is supported by the scientific staff in the laboratories of both NOW Foods and the raw material supplier, both of which have a mutual interest in protecting the integrity and efficacy of this product.

AHCC® is a rich source of polysaccharides such as beta glucan 1,3 and activated hemicellulose produced by enzymatic modification of organic medicinal mushrooms, including shiitake. It also has been shown to support normal levels of macrophages and cytokines, further strengthening the immune system.

This formula is suitable for vegetarians and is offered in Vcaps.

SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, take 2 Vcaps® 3 times daily, preferably on an empty stomach.

COMPLEMENTARY PRODUCTS: Antioxidants, Astragalus, Colostrum, Dr. Verghese Liver Formula, Immune Renew, Indole-3-Carbinol (I3C), Inositol Hexaphosphate (IP-6),

CAUTIONS: None.

PRODUCT SPECIFIC: None

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems. Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container.

DISCLAIMER: Information given here may vary from what is shown on the product label because this represents my own professional knowledge and understanding of the science underlying the formula and ingredients. The information in this review should not be used as diagnosis, prescription or as a specific product claim.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

Aviles H, Belay T, Fountain K, Vance M, Sun B, Sonnenfeld G. (2003) Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infectin in mice in the hindlimb-unloading model of spaceflight conditions. J Appl Physiol 95:491-496.

Burikhanov RB, Wakame K, Igarashi Y, Wang S, Matsuzaki S (2000) Suppressive Effect of Active Hexose Correlated Compound (AHCC®) on Thymic Apoptosis Induced by Dexamethasone in the Rat. Endocrine Regulations 34:181-188. Matsui Y, et al. (2002) Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. J Hepatol. 2002 Jul;37(1):78-86. PMID: 12076865 Matsushita K, et al. (1998) Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma. Anti-Cancer Drugs 9:343-350. Sun B, Wakame K, Mukoda T, Toyoshima A. Kanazawa T, Kosuna K (1997) Preventive Effects of AHCC® on Carbon Tetrachloride Induced Liver Injury in Mice. Nat Med 51(4):310-315.

Ye SF, Ichimura K, Wakame K, Ohe M. Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci. 2003 Dec 19;74(5):593-602. PMID: 14623030 Ye SF, Wakame K, Ichura K, Matsuzaki S (2004) Amelioration by active hexose correlated compound of endocrine disturbances induced by oxidative stress in the rat. Endocr Regul 38(1):7-13.



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VitaBerry Plus+ Fact Sheet
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Date: December 07, 2005 05:38 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: VitaBerry Plus+ Fact Sheet

VitaBerry Plus+ Fact Sheet

Neil E. Levin, CCN, DANLA 3/18/05

LIKELY USERS: Antioxidant users who want the best food source formula; People seeking polyphenols or ellagic acid supplements; Those who don’t eat fruit and want some of their benefits

KEY INGREDIENTS: VitaBerry extract, Hi-Active Orange Extract, Pomegranate Extract (420 mg) (400 mg) (100 mg)

MAIN PRODUCT FEATURES: This is a high antioxidant (high ORAC: 2,500 units per serving of oxygen radical absorbing capacity), proprietary blend of fruit extracts & concentrated powders containing Wild Blueberry extract, Grape & Grape seed extract, Raspberry & Raspberry seed extract, Cranberry, Prune, Tart Cherry, Wild Bilberry extract & Strawberry powder. Fortified with Hi-Active Orange Extract (Freeze-dried Orange (Citrus sinensis) powder with minimum of 40% vitamin C) and Pomegranate Extract (80% Polyphenols and 40% Ellagic Acid).

Provides a broad-spectrum antioxidant blend with phytochemicals such as anthocyanins, chlorogenic acid, ellagic acid, quinic acid, resveratrol etc. in a single “0” size vegetarian capsule. There is a synergistic effect of mixing fruit antioxidants that provides antioxidant protection greater than is predicted by measuring each fruit source used in the mix individually.

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: There will be some natural variation in color, taste and odor from these fruit sources. A special freeze drying technique preserves the antioxidant value of whole fruits in a concentrated form.

SERVING SIZE & HOW TO TAKE IT: Serving is 2 Vcaps. Take one or more servings per day as an antioxidant supplement. May be taken with food or on an empty stomach (this is food).

COMPLEMENTARY PRODUCTS: All antioxidants.

CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This information has not been reviewed by the FDA or the company posting it. Information given here may vary from what is given on the product label because this page represents my understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

Bagchi D, Sen CK, Bagchi M, Atalay M. Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemistry (Mosc). 2004 Jan;69(1):75-80, 1 p preceding 75. Review. PMID: 14972022

Gemma C, Mesches MH, Sepesi B, Choo K, Holmes DB, Bickford PC. Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines. J Neurosci. 2002 Jul 15;22(14):6114-20. PMID: 12122072

Huang D, Ou B, Prior RL. The Chemistry behind Antioxidant Capacity Assays. J Agric Food Chem. 2005 Mar 23;53(6):1841-1856. PMID: 15769103

Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. Br J Nutr. 2002 Oct;88(4):389-98. PMID: 12323088

Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem. 2002 Dec 18;50(26):7731-7. PMID: 12475297

Prior RL, Cao G. Analysis of botanicals and dietary supplements for antioxidant capacity: a review. J AOAC Int. 2000 Jul-Aug;83(4):950-6. Review. PMID: 10995120

Prior RL, Cao G. In vivo total antioxidant capacity: comparison of different analytical methods. Free Radic Biol Med. 1999 Dec;27(11-12):1173-81. Review. PMID: 10641708

Prior RL, Hoang H, Gu L, Wu X, Bacchiocca M, Howard L, Hampsch-Woodill M, Huang D, Ou B, Jacob R. Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples. J Agric Food Chem. 2003 May 21;51(11):3273-9. PMID: 12744654

Proteggente AR, Pannala AS, Paganga G, Van Buren L, Wagner E, Wiseman S, Van De Put F, Dacombe C, Rice-Evans CA. The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C composition. Free Radic Res. 2002 Feb;36(2):217-33. PMID: 11999391

Roy S, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, Sen CK. Anti-angiogenic property of edible berries. Free Radic Res. 2002 Sep;36(9):1023-31. PMID: 12448828

Sofic E, Rustembegovic A, Kroyer G, Cao G. Serum antioxidant capacity in neurological, psychiatric, renal diseases and cardiomyopathy. J Neural Transm. 2002 May;109(5-6):711-9. PMID: 12111462

Stintzing FC, Stintzing AS, Carle R, Frei B, Wrolstad RE. Color and antioxidant properties of cyanidin-based anthocyanin pigments. J Agric Food Chem. 2002 Oct 9;50(21):6172-81. PMID: 12358498

Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem. 2004 Jun 16;52(12):4026-37. PMID: 15186133

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TMG Fact Sheet
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Date: December 07, 2005 02:13 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: TMG Fact Sheet

TMG Fact Sheet

Neil E. Levin, CCN, DANLA 03/07/05

LIKELY USERS: People with high homocysteine levels; People with risks of developing Alzheimer’s Disease; People needing greater metabolism of fats; People with liver detoxification challenges; People consuming alcohol KEY INGREDIENTS: TMG is composed of three methyl groups attached to a glycine atom. It can “donate” methyl groups.

MAIN PRODUCT FEATURES: TMG is a metabolite of the B vitamin family product called Choline. Choline has 4 methyl groups, TMG has 3 and DMG has 2. These substances plus Folic acid, Vitamin B-12 and SAM-e are all methyl donors. Methyl donors can contribute methyl groups to biological processes such as liver function, detoxification and cellular replication (production of new cells). Methylation protects the kidneys and stimulates production of the fat-transporting molecule l-carnitine.

TMG helps the liver metabolize fats, preventing the accumulation of fats in the liver. It also helps to detoxify chemicals in the liver, while protecting the liver from being damaged by those chemicals.

Methylation with TMG helps to convert the dangerous, inflammatory chemical homocysteine into the amino acid methionine. TMG may lower homocysteine when B-6, B-12 and folic acid cannot.

ADDITIONAL PRODUCT INFORMATION: TMG is also known as Betaine and is a component of Betaine hydrochloride (Betaine HCl), a stomach acid supplement that is very acidic. But Betaine HCl is not used in the same way as TMG. TMG is not highly acidic and will not supplement low stomach acid.

TMG may be useful for autistic children, along with B-6 and magnesium. It may also be useful in strengthening the body’s immune response against pathogenic bacteria. There is very preliminary evidence that TMG and methyl donors may help against some forms of seizures.

DMG has been used as a sports supplement. TMG is 50% more effective than DMG in any application where the methyl groups are useful. Otherwise, they can used interchangeably.

SERVING SIZE & HOW TO TAKE IT: One serving per day, or up to 6,000 mg., as needed.

COMPLEMENTARY PRODUCTS: SAM-e, Milk Thistle (Silymarin), Dr. Verghese’s Liver Detoxifier & Regenerator, Antioxidants, NAC, Homocysteine Regulators, D-Flame, Detox Support

CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement.

People with Parkinson’s or taking L-dopa should not use methyl donors like TMG without a physician’s specific approval and supervision. There are no other known drug interactions with TMG.

This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This is not an official publication by any company, nor has this information been screened or approved by the FDA or any private company.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:

General:

Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49. Review. PMID: 15321791

Methylation:

Barak AJ, Tuma DJ. Betaine, metabolic by-product or vital methylating agent? Life Sci 1983;32:771-4 [review].

Benson R, Crowell B, Hill B, et al. The effects of L-dopa on the activity of methionine adenosyltransferase: relevance to L-dopa therapy and tolerance. Neurochem Res 1993;18:325–30.

Chambers ST. Betaines: their significance for bacteria and the renal tract. Clin Sci 1995;88:25-7 [review].

Charlton CG, Crowell B Jr. Parkinson’s disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav 1992;43:423–31.

Charlton CG, Mack J. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Mol Neurobiol 1994;9:149–61.

Cheng H, Gomes-Trolin C, Aquilonius SM, et al. Levels of L-methionine S-adenosyltransferase activity in erythrocytes and concentrations of S-adenosylmethionine and S-adenosylhomocysteine in whole blood of patients with Parkinson’s disease. Exp Neurol 1997;145:580–5.

Crowell BG Jr, Benson R, Shockley D, Charlton CG. S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson’s disease-like symptoms. Behav Neural Biol 1993;59:186–93.

Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].

Homocysteine:

Brosnan JT, Jacobs RL, Stead LM, Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol. 2004;51(2):405-13. Review. PMID: 15218538 Gahl WA, Bernardini I, Chen S, et al. The effect of oral betaine on vertebral body bone density in pyridoxine-non-responsive homocystinuria. J Inherit Metab Dis 1988;11:291-8.

Olthof MR, van Vliet T, Boelsma E, Verhoef P. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003 Dec;133(12):4135-8. PMID: 14652361

Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab. 2005 Feb;6(1):15-22. PMID: 15720203

Schwab U, Torronen A, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa M. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr. 2002 Nov;76(5):961-7. PMID: 12399266

Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].

van Guldener C, Janssen MJ, de Meer K, et al. Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients. J Intern Med 1999;245:175-83.

Wendel U, Bremer HJ. Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency. Eur J Pediatr 1984;142:147-50.

Wilcken DE, Wilcken B, Dudman NP, Tyrrell PA. Homocystinuria—the effects of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med 1983;309:448-53.

Wilcken DE, Dudman NP, Tyrrell PA. Homocystinuria due to cystathionine beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive patients. Metabolism. 1985 Dec;34(12):1115-21. PMID: 3934499

Liver function:

Babucke G, Sarre B. Clinical experience with betain citrate. Med Klin 1973;68:1109-13 [in German].

Barak AJ, Beckenhauer HC, Badakhsh S, Tuma DJ. The effect of betaine in reversing alcoholic steatosis. Alcohol Clin Exp Res 1997;21:1100-2.

Barak AJ, Beckenhauer HC, Matti J, Tuma DJ. Dietary betaine promotes generation of hepatic S-adenosylmethioine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res 1993;17:552-5.

Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol 1996;13:395-8 [review]. PMID: 8836329

Freed WJ. Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine. Pharmacol Biochem Behav. 1985 Apr;22(4):641-3. PMID: 2581277

Junnila M, Barak AJ, Beckenhauer HC, Rahko T. Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats. Vet Hum Toxicol 1998;40:263-6.

Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003 May;124(5):1488-99. PMID: 12730887

Kettunen H, Tiihonen K, Peuranen S, Saarinen MT, Remus JC. Dietary betaine accumulates in the liver and intestinal tissue and stabilizes the intestinal epithelial structure in healthy and coccidia-infected broiler chicks. Comp Biochem Physiol A Mol Integr Physiol. 2001 Nov;130(4):759-69. PMID: 11691612

Kim SK, Kim YC, Kim YC. Effects of singly administered betaine on hepatotoxicity of chloroform in mice. Food Chem Toxicol 1998;36:655-61.

McCarty MF. Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy. Med Hypotheses. 2000 Sep;55(3):189-94. PMID: 10985907

Murakami T, Nagamura Y, Hirano K. The recovering effect of betaine on carbon tetrachloride-induced liver injury. J Nutr Sci Vitaminol 1998;44:249-55.

Poschl G, Stickel F, Wang XD, Seitz HK. Alcohol and cancer: genetic and nutritional aspects. Proc Nutr Soc. 2004 Feb;63(1):65-71. Review. PMID: 15070439

Semmler F. Treatment of liver diseases, especially of fatty liver with betaine citrate. Ther Ggw 1977;116:2113-24 [in German].

Zapadniuk VI, Panteleimonova TN. [Cholagogic effect of trimethylglycine in normal animals of different ages and in experimental atherosclerosis] Biull Eksp Biol Med. 1987 Jul;104(7):30-2. Russian. PMID: 3620644

Autism & Seizures:

Rimland B. Seizures, Vitamin B6, DMG, and Sudden Speech. Autism Research Review International. 1996;10(2):1.

Roach ES, Carlin L. N,N-dimethylglycine for epilepsy. N Engl J Med. 1982;307:1081-82.

Vitamin B6/DMG. Letters to the Editor, Autism Research Interview International. 1994;8(2):6.

Immunity:

Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med. Apr1990;115(4):481-6.

Safety:

Hoorn AJ. Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions. Mutat Res. 1989 Apr;222(4):343-50. PMID: 2468082



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Allibiotic CF Fact Sheet
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Date: December 07, 2005 01:37 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Allibiotic CF Fact Sheet

Allibiotic CF Fact Sheet

Neil E. Levin, CCN, DANLA 03/09/05

LIKELY USERS: People seeking support of the immune system and intestinal flora

KEY INGREDIENTS: Allicin (“AlliSure” patented, stabilized allicin from fresh garlic); Olive Leaf Extract (Olea Europaea with 18% minimum Oleuropein content); Elderberry extract, from fruit/berry, 60:1 concentrate (equivalent to 2,500 mg. of fresh berries of Sambucus nigra); Oil of Oregano (wild oregano from Origanum vulgare) ImmunEnhancer AG (trademarked Arabinogalactan from Larch Tree, Larix occidentalis)

MAIN PRODUCT FEATURES: AlliSure is the clinically tested, patented and stable form of allicin. Not allicin potential, but actual allicin. Allicin represents the immune supporting nutrients of raw garlic, and is chemically similar to penicillin, though with different physical properties. AlliSure shares garlic’s abilities to help maintain healthy cholesterol and blood pressure levels, and also has been shown to raise levels of a key T cell to enhance immune system function. Like raw garlic, AlliSure has antimicrobial properties linked to its ability to react with sulfur-containing metabolic enzymes. Allicin is also shown in studies to play a role in controlling blood sugar and abnormal cell growth.

Black Elderberries have strong antioxidant properties, containing flavonoids like anthocyanidins. They have been studied in relation to inhibition of viral replication and of minor inflammations.

Olive Leaf has been used as an antioxidant, cholesterol and blood viscosity regulator, and vasodilator. But its most important use has been as a way to help the body deal with undesirable organisms in the vital respiratory and intestinal areas.

Oil of Oregano (wild oregano, wild marjoram) contains carvacrol and thymol, which are responsible for much of its antimicrobial activities. It also has some anti-inflammatory effects.

Arabinogalactan from Larch tree bark (ImmunEnhancer AG) can help speed the immune system’s response to undesirable organisms and is often compared to Echinacea. It has also been shown to promote the growth of beneficial intestinal bacteria.

ADDITIONAL PRODUCT INFORMATION: Patented and trademarked ingredients enhance quality controls and have clinical research. Rosemary Oil provides antioxidant protection for the capsule contents. Enteric coating protects the capsule from stomach acid to deliver its contents past the stomach. This helps to assure full potency and reduces the possibility of the oils repeating.

SERVING SIZE & HOW TO TAKE IT: One softgel twice daily, preferably with meals. Try one before using the full dose.

COMPLEMENTARY PRODUCTS: Probiotics, Antioxidants, D-Flame

CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Discontinue use if any uncomfortable side effects occur. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

ALLICIN:

Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther. 2001 Jul-Aug;18(4):189-93. (AlliSure was used in this study.)

Abramovitz D, Gavri S, Harats D, Levkovitz H, Mirelman D, Miron T, Eilat-Adar S, Rabinkov A, Wilchek M, Eldar M, Vered Z. Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet. Coron Artery Dis. 1999 Oct;10(7):515-9. PMID: 10562920

Ankri S, Miron T, Rabinkov A, Wilchek M, Mirelman D. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob Agents Chemother. 1997 Oct;41(10):2286-8. PMID: 9333064

Cellini L, Di Campli E, Masulli M, Di Bartolomeo S, Allocati N. Inhibition of Helicobacter pylori by garlic extract (Allium sativum). FEMS Immunol Med Microbiol. 1996 Apr;13(4):273-7. PMID: 8739190

Chowdhury AK, Ahsan M, Islam SN, Ahmed ZU. Efficacy of aqueous extract of garlic & allicin in experimental shigellosis in rabbits. Indian J Med Res. 1991 Jan;93:33-6.

Eilat S, Oestraicher Y, Rabinkov A, Ohad D, Mirelman D, Battler A, Eldar M, Vered Z. Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic. Coron Artery Dis. 1995 Dec;6(12):985-90. PMID: 8723021

Elkayam A, Mirelman D, Peleg E, Wilchek M, Miron T, Rabinkov A, Oron-Herman M, Rosenthal T. The effects of allicin on weight in fructose-induced hyperinsulinemic, hyperlipidemic, hypertensive rats. Am J Hypertens. 2003 Dec;16(12):1053-6. PMID: 14643581

Feldberg RS, Chang SC, Kotik AN, Nadler M, Neuwirth Z, Sundstrom DC, Thompson NH. In vitro mechanism of inhibition of bacterial cell growth by allicin. Antimicrob Agents Chemother. 1988 Dec;32(12):1763-8.

Focke M, Feld A, Lichtenthaler K. Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase. FEBS Lett. 1990 Feb 12;261(1):106-8.

Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr Cancer. 2000;38(2):245-54. PMID: 11525603

Patya M, Zahalka MA, Vanichkin A, Rabinkov A, Miron T, Mirelman D, Wilchek M, Lander HM, Novogrodsky A. Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21ras. Int Immunol. 2004 Feb;16(2):275-81. PMID: 14734613

Rabinkov A, Miron T, Mirelman D, Wilchek M, Glozman S, Yavin E, Weiner L. S-Allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties. Biochim Biophys Acta. 2000 Dec 11;1499(1-2):144-153. PMID: 11118647

Rabinkov A, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochim Biophys Acta. 1998 Feb 2;1379(2):233-44. PMID: 9528659

Sela U, Ganor S, Hecht I, Brill A, Miron T, Rabinkov A, Wilchek M, Mirelman D, Lider O, Hershkoviz R. Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression. Immunology. 2004 Apr;111(4):391-9. PMID: 15056375

Shadkchan Y, Shemesh E, Mirelman D, Miron T, Rabinkov A, Wilchek M, Osherov N. Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis. J Antimicrob Chemother. 2004 May;53(5):832-6. Epub 2004 Mar 24. PMID: 15044429

Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC. Antiviral properties of garlic: in vitro effects on influenza B, herpes simplex and coxsackie viruses. Planta Med. 1985 Oct;(5):460-1. PMID: 3001801

Uchida Y, Takahashi T, Sato N. [The characteristics of the antibacterial activity of garlic (author's transl)] Jpn J Antibiot. 1975 Aug;28(4):638-42. PMID: 1099271

Yasuo Yamada and Keizô Azuma. Evaluation of the In Vitro Antifungal Activity of Allicin. Antimicrob Agents Chemother. 1977 April; 11(4): 743–749.

ELDERBERRY:

Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 423.

Gruenwald J, Brendler T, Jaenicke C, et al. (eds). PDR for Herbal Medicines. Montvale, NJ: Medical Economics, 1998, 1116–7.

Mascolo N, Autore G, Capasso G, et al. Biological screening of Italian medicinal plants for anti-inflammatory activity. Phytother Res 1987;1:28–31.

Murkovic M, Abuja PM, Bergmann AR, et al. Effects of elderberry juice on fasting and postprandial serum lipids and low-density lipoprotein oxidation in healthy volunteers: a randomized, double-blind, placebo-controlled study. Eur J Clin Nutr. Feb2004;58(2):244-9.

Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 104–5.

Yesilada E. Inhibitory Effects of Turkish Folk Remedies on Inflammatory Cytokines: Interleukin-1Alpha, Interleukin-1Beta and Tumor Necrosis Factor Alpha. J Ethnopharmacol. Sept1997;58(1):59-73. Youdim KA, Martin A, Joseph JA. Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radical Biol Med 2000;29:51–60.

Zakay-Rones Z, Varsano N, Zlotnik M, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Alt Compl Med 1995;1:361–9.

OLIVE LEAF EXTRACT:

American Herbal Products Association. Use of Marker Compounds in Manufacturing and Labeling Botanically Derived Dietary Supplements. Silver Spring, MD: American Herbal Products Association; 2001.

Bennani-Kabchi N, et al. Effects of Olea europea var. oleaster leaves in hypercholesterolemic insulin-resistant sand rats. Therapie. Nov1999;54(6):717-23.

Bisignano G, et al. On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. J Pharm Pharmacol. Aug1999;51(8):971-4. Gonzalez M, et al. Hypoglycemic activity of olive leaf. Planta Medica. 1992;58:513-515. Visoli F, et al. Oleuropein protects low density lipoprotein from oxidation. Life Sciences. 1994;55:1965-71. PDR for Herbal Medicines, 2nd edition. Montvale, NJ: Medical Economics Company; 2000:557.

Petroni A, et al. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil.Thromb Res. Apr1995;78(2):151-60. Pieroni A, et al. In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves. Pharmazie. Oct1996;51(10):765-8. Zarzuelo A, et al. Vasodilator effect of olive leaf. Planta Med. Oct1991;57(5):417-9. OREGANO OIL (OIL OF OREGANO, WILD OREGANO, WILD MARJORAM):

Dorman HJ, et al. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. Feb2000;88(2):308-16. Force M, et al. Inhibition of enteric parasites by emulsified oil of oregano in vivo. Phytother Res. May2000;14(3):213-4.

Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999;86:985–90.

Kelm MA, Nair MG, Strasburg GM. Antioxidant and Cyclooxygenase Inhibitory Phenolic Compounds from Ocimum sanctum Linn. Phytomedicine. Mar2000;7(1):7-13. Lamaison JL, et al. Medicinal Lamiaceae with antioxidant properties, a potential source of rosmarinic acid. Pharm Acta Helv. 1991;66(7):185-8.

Ponce MM, Navarro AI, Martinez GMN, et al. In vitro effect against Giardia of 14 plant extracts. Rev Invest Clin 1994;46:343–7 [in Spanish].

Stiles JC, Sparks W, Ronzio RA. The inhibition of Candida albicans by oregano. J Applied Nutr 1995;47:96–102.

Tantaoui EA, Beraoud L. Inhibition of growth and aflatoxin production in Aspergillus parasiticus by essential oils of selected plant materials. J Environ Pathol Toxicol Oncol 1994;13:67–72. ImmunEnhancer AG (Larch tree Arabinogalactan)

Corado J, et al. Impairment of Natural Killer (NK) Cytotoxic Activity in Hepatitis C Virus (HCV) Infection. Exp Immunol. 1997;109:451-457. Currier NL, Lejtenyi D, Miller SC. Effect over time of in-vivo administration of the polysaccharide arabinogalactan on immune and hemopoietic cell lineages in murine spleen and bone marrow. Phytomedicine. 2003 Mar;10(2-3):145-53. PMID: 12725568

Egert D, et al. Studies on Antigen Specificity of Immunoreactive Arabinogalactan Proteins Extracted from Baptisia tinctoria and Echinacea purpurea. Planta Med. 1992;58:163-165. Gonda R, et al. Arabinogalactan Core Structure and Immunological Activities of Ukonan C, An Acidic Polysaccharide from the Rhizome of Curcuma longa. Biol Pharm Bull. 1993;16:235-238. Hagmar B, et al. Arabinogalactan Blockade of Experimental Metastases to Liver by Murine Hepatoma. Invasion Metastasis. 1991;11:348-355. Kelly GS. Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide. Altern Med Rev. 1999 Apr;4(2):96-103. Review. PMID: 10231609

Kim LS, Waters RF, Burkholder PM. Immunological activity of larch arabinogalactan and Echinacea: a preliminary, randomized, double-blind, placebo-controlled trial. Altern Med Rev. 2002 Apr;7(2):138-49. PMID: 11991793

Levine PH, et al. Dysfunction of Natural Killer Activity in a Family With Chronic Fatigue Syndrome. Clin Immunol Immunopathol. 1998;88:96-104. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr. 2001 Aug;20(4):279-85. PMID: 11506055

Rolfe RD. The Role of Probiotic Cultures in the Control of Gastrointestinal Health. J Nutr. Feb2000;130(2S Suppl):396S-402S.

Salyers AA, Vercellotti JR, West SE, Wilkins TD. Fermentation of mucin and plant polysaccharides by strains of Bacteroides from the human colon. Appl Environ Microbiol. 1977 Feb;33(2):319-22. PMID: 848954

Uchida A. Therapy of Chronic Fatigue Syndrome. Nippon Rinsho. 1992;50:2679-2683.



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Astragalus Fact Sheet
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Date: December 07, 2005 01:15 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Astragalus Fact Sheet

Astragalus Fact Sheet

Neil E. Levin, CCN, DANLA 02/10/05

LIKELY USERS: Everyone seeking a healthy immune system; Those lacking energy

KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg)

MAIN PRODUCT FEATURES: A Chinese “tonic herb” used in Traditional Chinese Medicine for night sweats, diarrhea and lack of energy. Tonic herbs are often known as “adaptogens”, helping the body adapt to stresses and modulating immune system responses. Some reports credit Astragalus with shortening colds and strengthening the heart.Astragalus additionally contains triterpene glycosides, also known as astragalosides.

ADDITIONAL PRODUCT INFORMATION: Vegetarian formula.May be useful to maintain the patient’s immunity in dialysis patients, those with liver problems and those who have suffered from strokes, according to Chinese studies (not as a treatment for those conditions!).

SERVING SIZE & HOW TO TAKE IT: For everyday use take one to five caps per day, either with meals or on an empty stomach.

COMPLEMENTARY PRODUCTS: Immune Renew, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and other antioxidants.

CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease, though there is some (not enough) evidence that Astragalus may balance immune function for at least one autoimmune disorder. This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES: 1. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
2. Zhang YD, Shen JP, Zhu SH, Huang DK, Ding Y, Zhang XL. Effects of astragalus (ASI, SK) on experimental liver injury Yao Xue Xue Bao. 1992;27(6):401-6. Chinese. PMID: 1442065
3. Sheng BW, Chen XF, Zhao J, He DL, Nan XY. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves. Chin Med J (Engl). 2005 Jan;118(1):43-9. PMID: 15642225
4. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol. 2005 Jan 4;96(1-2):71-7. PMID: 15588652
5. Li C, Cao L, Zeng Q. Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):379-84. PMID: 15587404
6. Wang SH, Wang WJ, Wang XF, Chen W. [Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Oct;24(10):926-8. Chinese. PMID: 15553830
7. Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 2004 Oct 8;323(1):133-41. PMID: 15351712
8. Mao SP, Cheng KL, Zhou YF. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3. Chinese. PMID: 15015443
9. Guo FC, Williams BA, Kwakkel RP, Li HS, Li XP, Luo JY, Li WK, Verstegen MW. Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poult Sci. 2004 Feb;83(2):175-82.
10. Shao BM, Xu W, Dai H, Tu P, Li Z, Gao XM. A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Commun. 2004 Aug 6;320(4):1103-11. PMID: 15249203
11. Zhang BQ, Hu SJ, Shan QX, Sun J, Xia Q. [Relaxant effect of Astragalus membranaceus on smooth muscle cells of rat thoracic aorta.] Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005 Jan;34(1):65-8. Chinese. PMID: 15693127
12. Luo Y, Qin Z, Hong Z, Zhang X, Ding D, Fu JH, Zhang WD, Chen J. Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neurosci Lett. 2004 Jun 17;363(3):218-23. PMID: 15182947
13. Tan BK, Vanitha J. Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review. Curr Med Chem. 2004 Jun;11(11):1423-30.
14. Shu HY. Oriental Materia Medica: A Concise Guide. Palos Verdes, CA: Oriental Healing Arts Press, 1986, 521–3. 15. Klepser T, Nisly N. Astragalus as an adjunctive therapy in immunocompromised patients. Alt Med Alert 1999;Nov:125–8 [review].
16. Qun L, Luo Q, Zhang ZY, et al. Effects of astragalus on IL-2/IL-2R system in patients with maintained hemodialysis. Clin Nephrol 1999;52:333–4 [letter].
17. Tang W, Eisenbrand G. Chinese Drugs of Plant Origin. Berlin: Springer Verlag, 1992, 1056.
18. Li SQ, Yuan RX, Gao H. Clinical observation on the treatment of ischemic heart disease with Astragalus membranaceus. Chung Kuo Chung His I Chieh Ho Tsa Chih 1995;15:77–80 [in Chinese].
19. Chen LX, Liao JX, Guo WQ. Effects of Astragalus membranaceus on Left Ventricular Function and Oxygen Free Radical in Acute Myocardial Infarction Patients and Mechanism of Its Cardiotonic Action. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Mar1995;15(3):141-3.
20. Lei ZY, Qin H, Liao JZ. Action of Astragalus membranaceus on Left Ventricular Function of Angina Pectoris. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Apr1994;14(4):199-202,195.
21. Geng CS, et al. Advances in Immuno-pharmacological Studies on Astragalus membranaceus. Chin J Integ Trad West Med. 1986;6:62.
22. Shi HM, et al. Intervention of Lidocaine and Astragalus membranaceus on Ventricular Late Potentials. Zhongguo Zhong Xi Yi Jie He Za Zhi. Oct1994;14(10):598-600.
23. Griga IV. Effect of a Summary Preparation of Astragalus cicer on the Blood Pressure of Rats with Renal Hypertension and on the Oxygen Consumption by the Tissues. Farm Zh. 1977;6:64-66.
24. Kurashige S, Akuzawa Y, Endo F. Effects of astragali radix extract on carcinogenesis, cytokine production, and cytotoxicity in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine. Cancer Invest. 1999;17(1):30-5.
25. Wei H, Sun R, Xiao W, et al. Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients. Oncol Rep. Sep2003;10(5):1507-12.
26. PDR for Herbal Medicines, 2nd edition. Montvale, NJ: Medical Economics Company; 2000:56. American Herbal Products Association. Use of Marker Compounds in Manufacturing and Labeling Botanically Derived Dietary Supplements. Silver Spring, MD: American Herbal Products Association; 2001.



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Immune Renew Fact Sheet
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Date: December 07, 2005 01:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Immune Renew Fact Sheet

Immune Renew Fact Sheet Neil E. Levin, CCN, DANLA 02/10/05

LIKELY USERS: Everyone seeking a healthy immune system; People on low carb diets or non-whole grain diets that are lacking dietary beta-glucans

KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg). Proprietary blend of 8 organically grown “medicinal mushrooms” (200 mg)

MAIN PRODUCT FEATURES: Vegetarian formula. Polysaccharides in these US-grown mushrooms grown on organic brown rice include 1,3 Beta-glucans and terpenoids. Beta-glucans may stimulate the immune system in different ways. Triterpenoids may act as mild anticoagulants. Each mushroom may have a different effect; for example, one may stimulate T-cells and another Natural Killer cells, aiding in immune defense. Mushrooms have reported beneficial effects on liver health and promoting normal cell growth.

ADDITIONAL PRODUCT INFORMATION: Some extracts from these kinds of mushrooms have been used medicinally in Japan and China. The mushrooms include Turkey Tail, Sun Mushrooms, Maitake, Cordyceps, Phellinus, Lion’s Mane, Reishi and Shiitake. The astragalus extract also contains naturally occurring astragalosides. Mushrooms may help maintain normal cholesterol and triglyceride levels

SERVING SIZE & HOW TO TAKE IT: For everyday use take one or two caps per day, either with meals or on an empty stomach.

COMPLEMENTARY PRODUCTS: Vitamin C to break down beta-glucan structures for better absorption, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and antioxidants

CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease. Use with caution if using anticoagulants or blood pressure medication, as these mushrooms may have mildly synergistic effects to those drugs. Do not use if you have mold or mushroom allergies (or any sensitivities to mushrooms, cheese, etc.), which can potentially result in hives, rashes, breathing difficulties (including dry mouth or throat), stomach distress, diarrhea, or any other unusual side effect.

This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995
2. Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol. 1999;19(1):65-96.
3. Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002 Nov;60(3):258-74. Epub 2002 Sep 10.
4. Nanba H, Hamaguchi AM, Kuroda H. The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake). Chem Pharm Bull 1987;35:1162–8.
5. Yamada Y, Nanba H, Kuroda H. Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake). Chemotherapy 1990;38:790–6.
6. Nanba H. Immunostimulant activity in vivo and anti-HIV activity in vitro of 3 branched b-1–6-glucans extracted from maitake mushrooms (Grifola frondosa). VIII International Conference on AIDS, Amsterdam, 1992 [abstract].
7. Kubo K, Nanba H. Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. Biol Pharm Bull 1997;20:781–5.
8. Adachi K, Nanba H, Otsuka M, Kuroda H. Blood pressure lowering activity present in the fruit body of Grifola frondosa (maitake). Chem Pharm Bull 1988;36:1000–6.
9. Jones K. Shiitake: A major medicinal mushroom. Alt Compl Ther 1998;4:53–9 [review].
10. Taguchi I. Clinical efficacy of lentinan on patients with stomach cancer: End point results of a four-year follow-up survey. Cancer Detect Prevent Suppl 1987;1:333–49.
11. Matsuoka H, Seo Y, Wakasugi H, et al. Lentinan potentiates immunity and prolongs survival time of some patients. Anticancer Res 1997;17:2751–6.
12. Guangwen Y, Jianbin Y, Dongqin L, et al. Immunomodulatory and therapeutic effects of lentinan in treating condyloma acuminata. CJIM 1999;5:190–2.
13. Jones K. Reishi mushroom: Ancient medicine in modern times. Alt Compl Ther 1998;4:256–66 [review].
14. Kammatsuse K, Kajiware N, Hayashi K. Studies on Ganoderma lucidum: I. Efficacy against hypertension and side effects. Yakugaku Zasshi 1985;105:531–3.
15. Jin H, Zhang G, Cao X, et al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Nimmi H, Xiu RJ, Sawada T, Zheng C. (eds). Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science, 1996, 131–8.
16. Suzuki H, et al. Immunopotentiating Substances in Lentinus edodes Mycelial Extract(LEM)-- Activation of Macrophage and Proliferation of Bone Marrow Cell. Nippon Shokakibyo Gakkai Zasshi. Jul1988;85(7): 1430.
17. Suzuki H, et al. Inhibition of the Infectivity and Cytopathic Effect of Human Immunodeficiency Virus by Water-soluble Lignin in an Extract of the Culture Medium of Lentinus edodes Mycelia (LEM). Biochem Biophys Res Commun. Apr1989;160(1):367-73.
18. Gordon M, et al. A Placebo-controlled Trial of the Immune Modulator, Lentinan, In HIV-positive Patients: A Phase I/II Trial. J Med. 1998;29(5-6):305-30.
19. Li JF, et al. Study on the Enhancing Effect of Polyporus Polysaccharide, Mycobacterium Polysaccharide and Lentinan on Lymphokine-activated Killer Cell Activity in vitro. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Apr1996;16(4):224-26.
20. Li KR, et al. Anti-atherosclerotic Properties of Higher Mushrooms (a Clinico-experimental Investigation. Vopr Pitan. Jan1989;1:16-19.
21. Shouji N, et al. Anticaries Effect of a Component From Shiitake (An Edible Mushroom). Caries Res. Feb2000;34(1):94-98.
22. Levy AM. Eosinophilia and Gastrointestinal Symptoms After Ingestion of Shiitake Mushrooms. J Allergy Clin Immunol. May1998;101(5):613-20.
23. Zjawiony JK. Biologically active compounds from Aphyllophorales (polypore) fungi. J Nat Prod. 2004 Feb;67(2):300-10.
24. Oliva D. Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini Rev Med Chem. 2004 Oct;4(8):873-9.
25. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
26. Borchers AT, Stern JS, Hackman RM, Keen CL, Gershwin ME. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med. 1999 Sep;221(4):281-93.
27. Mau JL, Lin HC, Chen CC. Antioxidant properties of several medicinal mushrooms. J Agric Food Chem. 2002 Oct 9;50(21):6072-7.
28. Hirasawa M, Shouji N, Neta T, Fukushima K, Takada K. Three kinds of antibacterial substances from Lentinus edodes (Berk.) Sing. (Shiitake, an edible mushroom). Int J Antimicrob Agents. 1999 Feb;11(2):151-7.
29. Rajewska J, Balasinska B. Biologically active compounds of edible mushrooms and their beneficial impact on health. Postepy Hig Med Dosw (Online). 2004 Oct 5;58:352-7.
30. Chang R. Functional properties of edible mushrooms. Nutr Rev. 1996 Nov;54(11 Pt 2):S91-3.
31. Lin ZB, Zhang HN. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin. 2004 Nov;25(11):1387-95. PMID: 15525457
32. Cheung NK, Modak S, Vickers A, Knuckles B. Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies. Cancer Immunol Immunother. 2002 Nov;51(10):557-64. Epub 2002 Sep 20. PMID: 12384807
33. Shamtsyan M, Konusova V, Maksimova Y, Goloshchev A, Panchenko A, Simbirtsev A, Petrishchev N, Denisova N. Immunomodulating and anti-tumor action of extracts of several mushrooms. J Biotechnol. 2004 Sep 30;113(1-3):77-83. PMID: 15380649
34. Zhang YD, Shen JP, Zhu SH, Huang DK, Ding Y, Zhang XL. Effects of astragalus (ASI, SK) on experimental liver injury Yao Xue Xue Bao. 1992;27(6):401-6. Chinese. PMID: 1442065
35. Sheng BW, Chen XF, Zhao J, He DL, Nan XY. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves. Chin Med J (Engl). 2005 Jan;118(1):43-9. PMID: 15642225
36. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol. 2005 Jan 4;96(1-2):71-7. PMID: 15588652
37. Li C, Cao L, Zeng Q. Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):379-84. PMID: 15587404
38. Wang SH, Wang WJ, Wang XF, Chen W. [Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Oct;24(10):926-8. Chinese. PMID: 15553830
39. Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 2004 Oct 8;323(1):133-41. PMID: 15351712
40. Mao SP, Cheng KL, Zhou YF. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3. Chinese. PMID: 15015443
41. Guo FC, Williams BA, Kwakkel RP, Li HS, Li XP, Luo JY, Li WK, Verstegen MW. Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poult Sci. 2004 Feb;83(2):175-82.



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Expanding Waist Lines
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Date: November 22, 2005 10:42 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Expanding Waist Lines

The environment is not only making us sick, but it is also making us fat. According to Dr. Paula Baille Hamilton, who published her work in the 2002 Journal of Alternative and Complimentary Medicine, between the years of 1930 and 2000, the rise in the use of synthetic chemicals matched the rise in the number of overweight and obese adults in the U.S. Many animal studies with pesticides support this theory. Even with food intake cut by 50 percent, when animals were treated with various chemicals they more than doubled their total body fat. Growth hormones and many pesticides in the food supply are making both humans and animals fat. Pesticides act as toxic nerve agents, virtually paralyzing the functioning of certain areas of the brain involved in weight control by increasing levels of fattening hormones and increasing appetite.

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PepZin GI™ helps relieve occasional discomfort.
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Date: September 20, 2005 05:40 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: PepZin GI™ helps relieve occasional discomfort.

PepZin GI™ helps relieve occasional discomfort.* CLINICAL TRIALS

In a randomized, multi-center, placebo-controlled double blind study, 299 patients suffering with symptoms of gastric discomfort were randomly allocated to receive either a zinc-L-carnosine complex or a placebo, or a control drug or its placebo for 8 weeks. Improvement ratings for a range of symptoms were taken at various points during the trial and compared with before treatment data. Of the 258 people who completed the trial, 136 were in the zinc-Lcarnosine group. Of the group, 92% of the participants were rated as “moderately improved” or better on an improvement scale across the category of symptoms including heartburn, tenderness, epigastric pain, diarrhea and constipation after 8 weeks.3

In another study, 28 patients with gastric discomfort were given a zinc-L-carnosine compound and monitored for 8 weeks. Improvement was rated on a scale of subjective and objective symptoms. After 4 weeks, the rate of those cases that were considered to be “significantly improved” was 68.4%. After eight weeks, the “significantly improved” number was 68.8%. Over 60% of these patients remained in the “significantly improved” category well after discontinuation of the treatment, suggesting a lasting effect of the zinc-L-carnosine compound beyond the time it is taken.4

Maintains a healthy GI environment.*

The mineral zinc in PepZin GI™ is a critical component to a number of physiological processes in our bodies. Some of these functions include growth and metabolism of cells, healing of wounds,and maintenance of carbohydrate and lipid metabolism.2

PepZin GI™ may also be able to favorably maintain the bacterial balance of the stomach and GI tract. Studies suggest that the zinc-L-carnosine co m pound may have effects on certain strains of harmful bacteria and, therefore, may be able to help maintain a GI environment that is favorable to health.1 By supporting the bacterial balance in the stomach, PepZin GI™ can help maintain a healthy mucosal lining.

Supports the health of gastric cells.*

PepZin GI™ has been studied for its ability to prevent free radical damage to gastric cells. In one such study, rat gastric cells were exposed to ethanol and hydrogen peroxide, two substances known to cause free radical damage to living cells. Cells were bathed in hydrogen peroxide, ethanol, zinc-L-carnosine, or a combination of zinc-L-carnosine with either ethanol or hydrogen peroxide. While the cells bathed in ethanol and hydrogen peroxide solutions all exhibited signs of damage due to free radical production, the cells that were bathed in zinc-L-carnosine were largely protected from the effects of free radical damage. The authors concluded that the zinc compound directly protected gastric mucosal cells from oxidant stress and alcohol induced damage.5

Additional research further confirms the gastro-protective effects of PepZin GI™. In another rat study, stomach lesions were induced by administration of the chemical monochloramine, a known pro-oxidant (producer of free radicals). One of the groups of rats was fed the zinc-Lcarnosine compound prior to being exposed to monochloramine. The researchers found that the size of the lesions in the group pre-treated with zinc-L-carnosine was significantly less than the lesions in the control group. The authors concluded that the zinc compound exerted a beneficial protective effect against monochloramine-induced stomach lesions.6

The zinc-L-carnosine in PepZin GI™ has also been shown to slow the development of aspirin induced stomach damage in rats. The researchers measurably detected lower levels of TNF-alpha in rats given zinc-L-carnosine as compared to the control rats. TNF-alpha is an inflammatory cytokine that is known to be released in response to gastric damage.7 These results may suggest a role for PepZin GI™ in protecting gastric cells by occasionally reducing the levels of certain cytokines in minor inflammation of the stomach.

Scientific References

1. Kuwayama H, et al. Polaprezinc. Nippon Rinsho 2002 Feb; 60 Suppl 2:717-720. 2.Matsukura T,Tanaka H. Applicability of zinc complex of l-carnosine for medical use. Biochemistry (Moscow) 2000;65(7):817-823. 3.Miyoshi A, et al. Clinical evaluation of Z-103 on gastric ulcer - a multicenter double-blind comparative study with cetraxate hydrochloride. Jpn PharmTher 1992;20(1):199-223. 4.Misawa T, et al. Clinical study of Z-103 - clinical effects on gastric ulcer and influence on endocrine function. Jpn PharmTher 1992; 20(1):245-254. 5. Hiraishi H, et al. Polaprezinc protects gastric mucosal cells from noxious agents through antioxidant properties in vitro. Aliment Pharmacl Ther 1999;13:261-269. 6. Kato S, Nishiwaki H, et al. Mucosal ulcerogenic action of monochloramine in rat stomachs: effects of polaprezinc and sucralfate. Dig Dis Sci 1997;42(10):2156-2163. 7.Naito Y, et al. Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury. Dig Dis Sci 2001;46(4):845-851.



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Sytrinol can lower Cholesterol by 27% - 34%
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Date: September 20, 2005 09:56 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Sytrinol can lower Cholesterol by 27% - 34%

Sytrinol – MultiPronged Heart Health

According to the American Heart Association, more than 60 million Americans suffer from on of more forms of cardiovascular imbalances. When we add in those individuals with blood cholesterol concerns, we see over 100 million Americans who may be in need of specific diet and lifestyle recommendations for achieving and maintaining heart health.

Aside from the generalized recommendations that we typically hear for heart health (lose weight, exercise more, and eat less fat and more fruits and vegetables) There are a number of potentially beneficial dietary supplements that may help to maintain cholesterol levels in the normal range. Among supplements there is a wide range of safety and efficacy between products—but a newer product called Sytrinol stands out for its clinical effectiveness.

Sytrinol is a patented blend of polymethoxylated flavones (from citrus) and tocotrienols (from palm fruit). One of the factors that sets Sytrinol apart from existing natural products for heart health is its multipronged approach to controlling multiple factors related to overall heart health—including control of cholesterol, cellular irritation, oxidation, triglycerides, and others.

Cholesterol Conundrum

While it is unarguable that cholesterol is an important contributor to overall heart health, it couldn’t be further from the truth that cholesterol is the “only” or even the most important factor when it comes to protecting your heart. Did you know that approximately HALF of all serious heart challenges each year are experienced by people with NORMAL cholesterol levels? If Cholesterol is not to blame, then what is?

In addition to total cholesterol levels (the “number” that you may know as 200 to 240 of other values in “mg/dl” units), we know how that LDL and HDL matter a lot (Low-density lipoprotein—the “bad” cholesterol, and High-density lipoprotein—the “good” cholesterol). We also know that some forms of the bad and LDL can be “Badder” than others—specifically those with lots of structural protein called “apolipoprotein B” (which tends to encourage LDL cholesterol to become embedded in your blood vessel linings—bad!). In addition to our total cholesterol, LDL, HDL, and the various apoproteins, we also need to know our triglyceride levels, our levels of cellular irritation, what our free radical load looks like, and what our antioxidant defenses are. Sytrinol addresses each of these important aspects of heart and health simultaneously.

The Sytrinol Solution

Polymethoxylated Flavones (PMFs) in Sytrinol are just what they sound like – flavonoid compounds with extra methoxy groups compared to “regular flavones. Like all flavonoids, the PMFs deliver potent antioxidant activity, but the PMF version is about three times more potent in its ability to address cholesterol levels (20% - 30% reduction in clinical Studies). The two primary PMFs are nobiletin and tangeretin.

In addition to the PMFs, Sytrinol contains palm tocotrienols—one of the most potent antioxidant nutrients known. An interesting effect of tocotrienols is a reduction in cholesterol synthesis in the liver—by a mechanism similar to (but safer than) the commonly utilized mechanism of inhibition of the HMG-CoA Reductase Enzyme.

Sytrinol is known to work via several unique mechanisms to reduce triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL). First, by reducing DGAT activity (Diacylglycerol acetyl transferase) and increasing liver PPAR (Peroxisome porliferator-activated receptor)—Sytrinol can reduce overall synthesis of TG (DGAT inhibition). The overall effect is to reduce TG levels in the blood by two complementary mechanisms.

In terms of LDL effects, Sytrinol also reduces both Apolipoprotein B levels (ApoB—needed for the synthesis of LDL particles) and MTTP levels (microsomal triglyceride transfer protein-needed to transfer fat into the new LDL particles). By reducing levels of both these tructural LDL components, Sytrinol reduces overall LDL levels, and thus total cholesterol levels, in the blood.

The clinical results behind Sytrinol are impressive—showing a reduction in levels of total, LDL, and triglycerides by 27% - 34% within 4 weeks. In one of these studies, ApoB levels were reduced (suggesting reduced LDL) and ApoA1 levels were increased (suggesting increased HDL)—as would be expected based on the biochemistry of PMFs and tocotrienols.

Sytrinol is also wonderfully safe—and at the effective dose of 300mg daily, users will benefit from its multipronged effects. One aspect of Sytrinol safety that I especially like is the finding that, unlike some flavonoids like naringin from grapefruit, there are no known risks of drug interactions with the form of citrus derived PMFs found in Sytrinol (certain grapefruit flavonoids can interfere with liver enzymes needed to metabolize many prescription drugs).

Summary

Not since Red Yeast Rice was removed from the market by the FDA, have we had a truly effective, multimechanism solution for cholesterol control (and nearly total heart health). There are certainly other options for addressing heart health and cholesterol levels, but among the available choices, such as policosanol, guggulipid, niacin, and plant sterols, we’re looking at about half the cholesterol-lowering ability (10% - 15% in most cases) compared to Sytrinol. If youre in the “borderline” zone of cholesterol levels (about 240mg/dl and below), you should absolutely consider Sytrinol to keep your cholesterol levels under control.

References

Kurowska EM, manthey Ja. Hypolipidemic effects of absorption of citrus polymethoxylated flavones in hamsters with diet-included hypercholesterolemia. J Argic food chem.. 2004 may 19;52(10):2879-86.

Kurowska EM, manthey Ja, Casaschi A, Theriault AG. Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, Tangeretin. Lipids 2004 feb;39(2):143-51.

Manthey JA, Grohmann K, Montanari A, Ash K, Manthey CL, Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human moncytes. J Nat Prod. 1999 mar;62(3)441-4.

Mora A, Paya M, rios JL, Alcaraz MJ. Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation. Biochem Parmacol. 1990 Aug 15;40(4):797-7.

Takanaga H, Ohnishi A, Yamada S, Matsuo H, Morimoto S, Shoyama Y, Ohtani H, Sawada Y. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol exp. Ther. 2000 Apr;293(1):230-6.

By: Shawn M. Talbott, PH.D.

Disclaimer: The above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider. The information in this article has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



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Curcumin - Turmeric Extract
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Date: August 19, 2005 12:47 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Curcumin - Turmeric Extract

Curcumin

Turmeric- History and Traditional Usage

Native to Southeast Asia, Curcuma longa is a tall
tropical shrub with large oblong leaves and pale yellow flowers.
The genus “Curcuma” belongs to the Zingiberaceae family, which
includes ginger.1 The plant possesses a large root structure
with fleshy, bulbous underground parts called “rhizomes.” These
rhizomes, known as turmeric root, are harvested at maturity,
dried and cured for commercial use. Chemical analysis shows that
dried turmeric contains essential and volatile oils, with a
curcuminoid content of 2.5 to 5.0 %.2

In addition to its
popularity as a spice, turmeric is used as a dye for cloth and
coloring agent in foods and cosmetics, thanks to its rich yellow
color. Turmeric also serves as a preservative, probably owing to
the antioxidant and antimicrobial properties of curcumin.
Extracts of Curcuma longa have demonstrated in vitro
antibacterial and anti-fungal effects.3

Turmeric is named in
ancient Ayurvedic and Chinese herbal texts as a traditional folk
remedy. Historically, turmeric was used externally for wounds,
and sprains, and internally for digestive complaints,
rheumatism, liver disorders, coughs and colds.4
Benefits

Protects cells and tissues by fighting free radicals.*

Supports joint function*

The numerous beneficial
effects attributed to turmeric stem in large measure from the
antioxidant properties of curcumin. Antioxidants neutralize free
radicals, which are highly unstable molecules that can damage
cellular structures through abnormal oxidative reactions.
Curcumin is a potent “scavenger” of the superoxide radical, a
free radical that initiates potentially harmful oxidative
processes such as lipid peroxidation.5 Through this activity,
curcumin has been shown to protect skin cells from the injurious
effect of nitroblue tetrazolium, a toxin that generates
superoxide radicals. Curcumin also increases survival of cells
exposed in vitro to the enzyme hypoxanthine/xanthine oxidase,
which stimulates superoxide and hydrogen peroxide production.
Curcumin itself is not toxic to cells, even at high
concentrations. Pure curcumin was shown to be less protective
than a mixture of curcuminoids, indicating a possible synergism
among curcuminoids.6 Because free radicals are involved in aging
and exert harmful effects on skin, these results suggest
curcumin may help slow skin aging.

Curcumin demonstrates
several other in vitro effects linked to free radical
scavenging. Curcumin scavenges nitric oxide, a compound
associated with the body’s inflammatory response.7 Pure curcumin
and turmeric extracts protect red blood cells from lipid
peroxidation induced by hydrogen peroxide.8 Curcumin has been
shown to protect DNA from oxidative damage, inhibit binding of
toxic metabolites to DNA, and reduce DNA mutations in the Ames’
test.9 Although additional studies suggest an anticarcinogenic
effect of curcumin, through protection of DNA,10 one in vitro
study found that curcumin induced DNA damage in human gastric
mucosal cells.11 It is speculated that curcumin may act as a
pro-oxidant in the presence of transition metal ions such as
copper and iron. (This is true for other antioxidants, including
vitamin C.) Curcumin also demonstrates in vitro inhibition of
COX-I and COX-II enzymes, which are involved in the inflammatory
reaction.12 Together these results strongly suggest that
curcumin is a potent bioprotectant with a potentially wide range
of therapeutic applications.

Animal studies- In vivo protective effects

Through its free radical scavenging
properties, curcumin has shown bioprotective effects in animals.
In one study, rats were treated with isoproterenol, a chemical
that causes cardiac hypertrophy (enlargement of the heart) due
to abnormal collagen metabolism. Co-treatment with curcumin
reversed the degradation of collagen and cardiac hypertrophy
induced by isoproterenol.13 Curcumin protects mice from
detrimental effects of radiation, by stabilizing the glyoxalase
system, a biological system that regulates cell division.14
Curcumin protects livers of rats from the damaging effects of
carbon tetrachloride (CCl4), a potent hepatoxin that injures the
liver via its free radical metabolite, CCl3.15,16 Curcumin
protected rats from alcohol-induced brain damage, in a study in
which oral administration of curcumin reversed lipid
peroxidation, reduced levels of free-radical metabolites and
increased levels of glutathione, a major physiologic
antioxidant.17 Curcuma longa extracts have shown
anti-inflammatory effects in rats.18

Human Trials

Curcumin exhibits free-radical scavenging ability when
administered to humans. In an open trial (uncontrolled), 18
healthy individuals ranging in age from 27 to 67 years consumed
a Curcuma longa extract, at a dose supplying 20 mg curcuminoids,
for 45 days. Before and after blood tests showed a statistically
significant decrease in lipid peroxides.19 Preliminary trials
have tested the anti-inflammatory action of curcumin, with
results that verify the traditional use of turmeric as an
anti-rheumatic herb. In a short-term double-blind, cross-over,
comparative study, 18 people received curcumin (1200 mg daily)
or phenylbutazone for two week periods. Both curcumin and
phenylbutazone produced measurable improvements in joint
flexibility and walking time. The subjects reported results only
with phenylbutazone, which may be explained by the short
duration of the trial.20 In a small placebo-controlled trial
comparing curcumin to phenylbutazone, 45 patients with
post-operative inflammation received curcumin, phenylbutazone or
placebo. The anti-inflammatory effects of curcumin and
phenylbutazone were comparable and superior to placebo.21
Curcumin has not been found to produce an analgesic (pain
relieving) effect.

Bioperine-Nature’s Absorption Enhancer
Boosts Curcumin Absorption*

Traditional Ayurvedic herbal
formulas often include black pepper and long pepper as
synergistic herbs. The active ingredient in both black pepper
and long pepper is the alkaloid, piperine. Experiments carried
out to evaluate the scientific basis for the use of peppers have
shown that piperine significantly enhances bioavailability when
consumed with other substances.22 Several double-blind clinical
studies have confirmed that Bioperine® increases absorption of
nutrients.23

Curcumin is poorly absorbed in the intestinal
tract, limiting its therapeutic effectiveness. Oral doses are
largely excreted in feces, and only trace amounts appear in the
blood. Concomitant administration of 20 mg of piperine with 2
grams of curcumin increases the bioavailability of curcumin by
2000%.24

Scientific References


1. Majeed, M., Badmaev,
V., Shivakumar, U., Rajendran, R. Curcuminoids. 1995.
Piscataway, NJ: NutriScience Publishers.
2. Srimal, R.C.
Turmeric: a brief review of its medicinal properties.
Fitoterapia 1997;68(6):483-93.
3. Ammon, H.P.T., Wahl, M.A.
Pharmacology of Curcuma longa. Planta Medica 1991;57:1-7.
4.
Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae).
The Protocol Journal of Botanical Medicine, Autumn
1995:43-46.
5. Rao, N.S., Rao, M.N.A. Free radical scavenging
activity of curcuminoids. Arzneim.-Forsch./Drug Res.
1996;46(2):169-171.
6. Bonté. F. et al. Protective effect of
curcuminoids on epidermal skin cells under free oxygen radical
stress. Planta Medica 1997;63:265-66.
7. Rao, S., Rao, M.N.A.
Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol.
1997;49:105-7.
8. Lalitha, S., Selvam, R. Prevention of
H2Os-induced red blood cell lipid peroxidation by aqueous
extracted turmeric. Asia Pacific J Clin Nutr
1999;8(2):113-14.
9. Deshpande, S.S., Maru, G.B. Effects of
curcumin on the formation of benzo[a]pyrene derived DNA adducts
in vitro. Cancer Letters 1995;96:71-80.
10. Subramanian, M., et
al. Diminution of singlet oxygen-induced DNA damage by curcumin
and related antioxidants. Mutation Research
1994;311:249-55.
11. Blasiak, J., Trzeciak, A., Kowalik, J.
Curcumin damages DNA in human gastric mucosa cells and
lymphocytes. Journal of Environmental Pathology, Toxicology and
Oncology 1999;18(4):271-76.
12. Ramsewak, R.S., DeWitt, D.L.,
Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory
activities of Curcumins I-III from Curcuma longa. Phytomedicine
2000;7(4):303-308.
13. Nirmala, C. Anand, S., Puvanakrishnan,
R. Curcumin treatment modulates collagen metabolism in
isoproterenol induced myocardial necrosis in rats. Molecular and
Cellular Biochemistry 1999;197:31-37.
14. Choudhary, D.,
Chandra, D. Kale, R.K. Modulation of radioresponse of glyoxalase
system by curcumin. Journal of Ethnopharmacology
1999;64:1-7.
15. Park, E-J. et al. Protective effect of
curcumin in rat liver injury induced by carbon tetrachloride. J
Pharm. Pharmacol. 2000;52:437-40.
16. Deshpande, U.R. et al.
Protective effect of turmeric (Curcuma longa L.) extract on
carbon tetrachloride-induced liver damage in rats. Indian
Journal of Experimental Biology 1998;36:573-77.
17.
Rajakrishnan, V. et al. Neuroprotective role of curcumin from
Curcuma longa on ethanol-induced brain damage. Phytotherapy
Research 1999;13:571-74.
18. Arora, R.B. Basu, N., Kapoor, V.,
Jain, A.P. Anti-inflammatory studies on Curcuma longa
(Turmeric). Indian J Med Res 1971;59(8):1289-95.
19.
Ramirez-Bosca, A. et al. Antioxidant curcuma extracts decrease
the blood peroxide levels of human subjects. Age
1995;18:167-69.
20. Deodhar, S.D., Sethi, R. Srimal. R.C.
Preliminary study on antirheumatic activity of curcumin
(diferoyl methane). Indian J Med Res 1980;71:632-34.
21.
Satoskar, R.R., Shah, S J. Shenoy, S.G. Evaluation of
anti-inflammatory property of curcumin (diferoyl methane) in
patients with postoperative inflammation. International Journal
of Clinical Pharmacology, Therapy and Toxicolgy
1986;24(12):651-54.
22. Atal, C., Zutshi, U., Rao, P.
Scientific evidence on the role of Ayurvedic herbals on
bioavailability of drugs. Journal of Ethnopharmacology
1981;4:229-232.
23. Bioperine®–Nature's Bioavailability
Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa
Corporation, Piscataway, N.J.
24. Shoba, G., et al. Influence
of piperine on the pharmacokinetics of curcumin in animals and
human volunteers. Planta Medica 1998;64(4):353-6.

© 2002
Doctor's Best, Inc. Revised 8/13/02

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.



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Benfotiamine raises the blood level of thiamine pyrophosphate (TPP)
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Date: August 02, 2005 03:52 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benfotiamine raises the blood level of thiamine pyrophosphate (TPP)

Benefits

Benfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine.4

Thiamine and its Co-enzyme, TPP

Thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically-catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name "thiamine diphosphate." In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as "active acetate." Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb’s cycle (citric acid cycle). The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called "oxidative decarboxylation," and for this reason, TPP was originally referred to as "cocarboxylase." TPP is thus vital to the cell’s energy supply. Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.

Benfotiamine and Glucose Metabolism Benfotiamine normalizes cellular processes fueled by glucose metabolites.

As long as glucose remains at normal levels, excess glucose metabolites do not accumulate within the cell. The bulk of the cell’s glucose supply is converted to pyruvic acid, which serves as substrate for production of acetyl CoA, the primary fuel for the Krebs cycle. Of the total amount of metabolic energy (in the form of ATP) released from food, the Krebs cycle generates about 90 percent.5 In the presence of elevated glucose levels, the electron transport chain, the final ATP-generating system in the mitochondrion, produces larger than normal amounts of the oxygen free radical "superoxide." This excess superoxide inhibits glyceraldehyde phosphate dehydrogenase (GAPDH), as key enzyme in the conversion of glucose to pyruvic acid, resulting in an excess of intermediate metabolites known as "triosephosphates." Increase triosephophate levels trigger several cellular mechanisms that result in potential damage to vascular tissue. Cells particularly vulnerable to this biochemical dysfunction are found in the retina, kidneys and nerves.

Benfotiamine has been shown to block three of these mechanisms: the hexosamine pathway, the diaglycerol-protein kinease C pathway and the formation of Advanced Glycation End-poducts. As discussed below, benfotiamine does this by activating transketolase, a key thiamin-dependent enzyme.6 Benfotiamine stimulates tranketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.* Transketolase diverts the excess fructose-6-phosphate and glyceraldehydes-3-phosphate, (formed by the inhibition of GAPDH, as mentioned above), into production of pentose-5-phosphates and erythrose-4-phosphate and away from the damaging pathways. Benfotiamine activates transketolase activity in bovine aortic endothelial cells incubated in glucose.6 To test benfotiamine’s ability to counteract these metabolic abnormalities caused by elevated blood glucose, studies have been done in diabetic rats. Benfotiamine increases transketolase activity in the retinas of diabetic rats, while concomitantly decreasing hexosamine pathway activity, protein kinase C activity and AGE formation.6

Benfotiamine and Protein glycation Benfotiamine controls formation of Advanced Glycation End-products (AGEs).

AGEs have an affinity for proteins such as collagen, the major structural protein in connective tissue. AGEs are formed through abnormal linkages between proteins and glucose. This occurs via a non-enzymatic glycosylation reaction similar to the "browning reaction" that takes place in stored food.7 At high glucose concentrations, glucose attaches to lysine, forming a Schiff base, which in turn forms "early glycosylation products." Once blood glucose levels return to normal levels, the amount of these early glycosylation products decreases, and they are not particularly harmful to most tissue proteins. On long-lived proteins such as collagen, however, early glycosylation products are chemically rearranged into the damaging Advanced Glycation End-products. AGE formation on the collagen in coronary arteries causes increased vascular permeability. This vessel "leakiness" allows for abnormal cross-linking between plasma proteins and other proteins in the vessel wall, comprising vascular function and potentially occluding the vessel lumen. A number of other potentially harmful events may also occur, including production of cytokines that further increase vascular permeability. Endothelin-1, a strong vasoconstrictor, is over produced, increasing the possibility of thrombosis and generation of oxygen free radicals is stimulated.8 It is vitally important to support normal glucose metabolic pathways so that formation of AGEs is minimized. Benfotiamine, in the test tube (in vitro) prevents AGE formation in endothelial cells cultured in high glucose by decreasing the glucose metabolites that produce AGEs.9 Endothelial cells make up the membranes that line the inner walls of organs and blood vessels. In a rat study comparing the effects of Benfotiamine with water-soluble thiamin, Benfotiamine inhibited AGE formation in diabetic rats while completely preventing formation of "glycooxidation products," which are toxic by products of chronic elevated blood glucose. AGE levels were not significantly altered by thiamin.10 Benfotiamine also normalized nerve function in the animals. After three months of administration, "nerve conduction velocity (NCV)," a measure of nerve function, was increased by both benfotiamine and thiamin; at six months, NCV was normalized by benfotiamine, whereas thiamin produced no further increases in this parameter.

Dysfunctional glucose metabolic pathways leading to AGE formation occurs in endothelial cells of the kidneys. In a recent animal study, benfotiamine was administered to rats with elevated glucose levels. Benfotiamine increased transketolase activity in the kidney filtration system of these rats, while at the same time shifting triosephophates into the pentose pathway and preventing protein leakage.11

Safety

Benfotiamine has an excellent tolerability profile and can be taken for long periods without adverse effects.3,12 The statements in this fact sheet have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Scientific References

1. Bitsch R, Wolf M, Möller J. Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative. Ann Nutr Metab 1991;35(2):292-6.

2. Schreeb KH, Freudenthaler S, Vormfelde SV, et al. Comparative bioavailability of two vitamin B1 preparations: benfotiamine and thiamine mononitrate. Eur J Clin Pharmacol 1997; 52(4):319-20.

3. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. Int J Clin Pharmacol Ther 1996;34(2):47-50.

4. Frank T, Bitsch R, Maiwald J, Stein G. High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfontiamine. Eur J Clin Pharmacol. 2000;56(3):251-7.

5. Pike RL, Brown ML. Nutrition, An Integrated Approach, 3rd Ed. New York:MacMillan; 1986:467.

6. Hammes H-P, Du X, Edlestein D, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic neuropathy. Nat Med 2003;9(3):294-99.

7. Monnier VM, Kohn RR, Cerami A. Accelerated age-related browning of human collagen in diabetes mellitus. Proc Natl Acad Sci 1984;81(2):583-7.

8. Brownlee M. The pathological implications of protein glycation. Clin Invest Med 1995;18(4):275-81.

9. Pomero F, Molinar Min A, La Selva M, et al. Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose. Acta Diabetol 2001;38(3):135-8.

10. Stracke H, Hammes HP, Werkman D, et al. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes 2001;109(6):300-6.

11. Babaei-Jadidi R, Karachalias N, Ahmed N, et al. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes 2003;52(8):2110-20.

12. Bergfeld R, MatsumaraT, Du X, Brownlee M. Benfotiamin prevents the consequences of hyperglycemia induced mitochondrial overproduction of reactive oxygen specifies and experimental diabetic neuropathy (Abstract) Diabetologia 2001; 44(Suppl1):A39.



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