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Search Term: " Model "
Study identifies a natural preservative in the arjun tree   
Date:
May 17, 2019 03:56 PM
Terminalia arjuna has been studied closely by researchers from India and New Zealand. Commonly known as the arjun tree, this plant was used on chevon sausages to test the properties of preservation. The study suggest that the it produced significantly lower values for total plate count, psychrophilic count, yeast and mold count, and free fatty acid values. The results showed an improved lipid oxidative stability and storage quality while refrigerated, thus suggesting that the arjun tree can be a novel natural meat preservative. Key Takeaways:
"Researchers from India and New Zealand explore the potential of Terminalia arjuna as a novel natural preservative in meat products." Read more: https://www.naturalnews.com/2019-04-09-study-identifies-a-natural-preservative-in-the-arjun-tree.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6329) Heart-healthy curcumin improves muscle function and increasesexercise capacity 
Date:
May 13, 2019 04:10 PM
There's a lot of buzz about curcumin these days and for good reason. A recent study published in The Journal of Applied Physiology suggests that it can help to improve athletic performance in heart failure patients. Other research has shown that it could reduce muscle loss in individuals with heart disease. Due to its potent antioxidant and anti-inflammatory effects properties, it also can be a very effective post-workout supplement. In fact, researchers found that people that consumed one gram of curcumin twice daily had decreased muscle injuries and less pain in their lower legs. Key Takeaways:
"For the study, researchers from the University of Nebraska Medical Center looked at the effects of curcumin on a mouse model of heart failure with reduced ejection fraction. The compound is known to promote activation of Nrf2 protein, which regulates the expression of antioxidant enzymes that prevent and repair damage from oxidative stress and boost exercise performance." Read more: https://www.naturalnews.com/2019-03-18-curcumin-improves-muscle-function-exercise.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6309) Reduce the effects of chemotherapy with safflower seeds
Date:
May 08, 2019 04:35 PM
Chemotherapy which is often shortened to chemo is the use of drugs to eliminate and reduce cancer cells. Because of its systemic effects and ability to kill cancer cells despite the site they are found, it has been widely used in conventional medicine and oncology to fight cancer. But the treatment is not without risks since it can include long term damage to sensitive organs in the body like the lungs, heart, and kidneys. A recent study that was published in the American Journal of Chinese Medicine took a look at the effect of chemotherapy on the kidneys. They studied the effectiveness of safflower seeds against the side effects of cisplatin, a chemotherapy drug used against cancer. They used animal models and compared the effect on damages to the kidneys. Cisplatin is not only used to treat cancer, it is used to prevent the spread of cancer to other parts of the body. It has some side effects which include nausea, vomiting, hair loss, dry skin, and hiccups. It is advisable that pregnant women and breastfeeding women not take it because it can harm the baby. When safflower seeds effect were studied, there were remarkable results discovered leading to the conclusion that safflower seeds were effective in reducing the effects of renal damage caused by cisplatin. Key Takeaways:
"The treatment, despite being touted as “effective against many forms of cancer,” isn’t without risk, which can include both acute and long-term damage to organs like the lungs, heart, nerves, and kidneys." Read more: https://www.naturalnews.com/2019-04-17-reduce-the-effects-of-chemotherapy-with-safflower-seeds.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6288) Oat extract can protect against alcohol-induced liver damage
Date:
May 02, 2019 02:59 PM
Eating oats may prevent liver damage caused by drinking, according to research published in the journal Nutrition Research. Indian researchers tested the effects of oat extract on mice with alcohol-induced liver damage. First, they pretreated mice with phenolic-enriched ethyl acetate fraction of oats at two levels every day for 12 days. Next, they induced liver damage in the same mice with doses of 50 percent ethanol every 12 hours. Their results showed that pretreatment with oat extract at higher dosages decreased the levels of liver injury. Key Takeaways:
"Research has found an association between consumption of oats and lower risk of cardiovascular disease, diabetes, and gastrointestinal disorders." Read more: https://www.naturalnews.com/2019-03-13-oat-extract-can-protect-against-alcohol-induced-liver-damage.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6244) A species of hawthorn has been found to control abnormally highblood sugar levels
Date:
May 02, 2019 02:45 PM
A team of researchers from the Middle East have found that a species of hawthorn, Crete hawthorn, has the ability to lower elevated levels of glucose in the blood. They have published their findings in the journal BMC Complementary and Alternative Medicine. Along with its effects on blood glucose, called its anti-hyperglycemic property, it also has hyperlipidemic properties, that is, the ability to protect the body against high levels of fat such as cholesterol in the blood. They carried out the study using mice that were induced with hyperglycemia through feeding them alloxan. The mice were then divided into two groups, one group receiving Crete hawthorn extracts and the other given a chemical for control. They also used another animal model to understand its hyperlipidemic properties and to investigate whether the plant had antioxidant and antimicrobial properties. The results of the findings were that Crete hawthorn had important antioxidant properties due to its containing phenols and flavonoids. They also found that it had antimicrobial properties because it acted against bacteria such as E. Coli and Staphylococcus aureus, among others. Key Takeaways:
"The mice were then divided into groups, with some receiving an ethanol extract from Crete hawthorn leaves while others were given glibenclamide for positive control." Read more: https://www.naturalnews.com/2019-03-12-hawthorn-controls-high-blood-sugar-levels.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6243) Eat more artichokes! Their leaves contain powerful compounds thatprotect you from diabetes
Date:
April 04, 2019 09:27 AM
Diabetes has the harmful potential of damaging the liver, kidneys, and pancreas. Fortunately, research is now showing that the consumption of artichoke leaves can protect your organs from this oncoming threat. This was concluded after a study was performed on rats, giving them a certain amount of alloxan each day which mimicked the effects of artichoke leaves. Once tissue was extracted from their organs, it showed that it was much less damaged than those who were not exposed to the alloxan. Key Takeaways:
"People who are at risk of diabetes and other metabolic disorders would do well to add artichokes (Cynara scolymus) in their diet to lower their chances of getting the disease, according to researchers from the University of Sfax in Tunisia." Read more: https://www.naturalnews.com/2019-02-04-artichoke-leaves-protect-you-from-diabetes.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6119) Research proves the healing potential of monk fruit on cancerpatients
Date:
April 04, 2019 09:20 AM
Monk fruit, which is already widely used as both an ingredient for traditional Chinese medicine and as a substitute for sugar, may also have beneficial properties for fighting cancer. Researchers from the Beijing University of Agriculture conducted studies of a monk fruit compound called mogroside V, and found that it can prevent the growth of pancreatic cancer cells, or even trigger them to die. Mogroside V is also a powerful antioxidant. Monk fruit may also provide health benefits by reducing how much processed sugar people eat. Key Takeaways:
"Mogroside V was used to treat several models of pancreatic cancer. It was shown to trigger death in cancer cells and prevent them from developing or spreading any further. Chinese researchers theorized that the plant-based compound disrupted the STAT3 signaling pathway that cancer cells used for communication." Read more: https://www.naturalnews.com/2019-02-06-the-healing-potential-of-monk-fruit-on-cancer-patients.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6117) Easily boost your immune system by eating more pomegranates, studyconcludes
Date:
March 27, 2019 10:34 AM
Pomegranates have long been recognized for their beautiful red seeds that present in a much more vibrant light than many other fruits. Now researchers are finding that pomegranates have several health benefits, especially when it comes to treating chronic inflammatory conditions. A study performed on mice showed that the inflammation biomarkers present within their systems were dramatically reduced when they were given pomegranate extract on a continual basis, showing that it could have a similar impact on humans. Key Takeaways:
"Scientists from King Saud University concluded that pomegranates can boost the immune system and treat diseases such as malaria." Read more: https://www.naturalnews.com/2019-01-27-easily-boost-your-immune-system-with-pomegranates.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6097) BREAKTHROUGH: Vitamin D supplements taken during pregnancy found toprevent autism in children
Date:
March 04, 2019 02:26 PM
Autism is a condition that affects thousands of children across the world. It is believed that autism begins during pregnancy. New research suggests that using Vitamin D supplements during pregnancy is a good way to prevent this devastating condition from occurring. It is exciting news for parents who are trying to conceive who want to ensure their baby has a great start from the very beginning. Learn how much Vitamin D to take and the best supplements to begin! Key Takeaways:
"Taking vitamin D supplements during pregnancy can prevent the onset of autism spectrum disorder in children, a recent animal study showed." Read more: https://www.naturalnews.com/2019-01-19-vitamin-d-supplements-taken-during-pregnancy-prevent-autism-in-children.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6061) Eating cruciferous greens help your immune system fight offintestinal pathogens
Date:
January 13, 2019 04:10 PM
The Francis Crick Institute has published new research on the useful properties of cruciferous vegetables in protecting against pathogens that attack your gastrointestinal tract. According to this research, kale, broccoli, and cauliflower can all help reduce your susceptibility to inflammatory bowel diseases. They do this by helping to mitigate the effects of a compound called Cyplal, which can inhibit your body’s ability to use a separate substance called aryl hydrocarbon receptor (AhR). This is good because when Cyplal interferes with AhR, it can leave you more vulnerable to gut parhogens. Key Takeaways:
"An article in The Francis Crick Institute news page reported that cruciferous vegetables are particularly beneficial when it comes to shielding the intestine from disease-causing microorganisms." Read more: https://www.naturalnews.com/2018-12-18-eating-cruciferous-greens-help-your-immune-system-fight-off-intestinal-pathogens.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5960) Researchers look at the powerful effect of mulberry fruit extracton insulin sensitivity
Date:
January 07, 2019 03:36 PM
One of the main chemicals in mulberry fruit is rosiglitazone, and studies are showing that mice given rosiglitazone had much lower insulin readings than those who were not given the substance. The mulberry fruit was able to accomplish this by improving the amount of a certain chemical called 'plasma membrane-glucose transporter 4'. This is what helps plasma enter the skeletal muscles. They think that this could potentially provide relief to those suffering from hyperglycemia or insulin resistance. Key Takeaways:
"The researchers constructed an animal Model with a strain of mice that simulated the symptoms of diabetes in humans. The lab animals were divided into three groups according to the treatment they received." Read more: https://www.naturalnews.com/2018-12-18-mulberry-fruit-extract-on-insulin-sensitivity.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5938) Your depression may be caused by chronic brain inflammation
Date:
November 15, 2018 12:51 PM
Depression is something that a ton of people in the world today suffer from. It is not an easy thing to deal with. However, if you are someone who has it, then you must find how you can cope with it. It may be hard but there is always something that you can do to help yourself. Understanding where depression comes from is difficult as well. However, some doctors say that it can be caused by some brain inflammation. Key Takeaways:
"Chronic inflammation is largely caused by unhealthy lifestyle habits such as poor diet, lack of physical exercise, and inadequate sleep, among others. These behaviors, while seemingly inconsequential initially, fuel the inflammation response long after it stops being helpful." Read more: https://www.naturalnews.com/2018-11-09-your-depression-may-be-caused-by-chronic-brain-inflammation.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5834) Gut microbes play a significant role in the central nervous system digestive health is linked to your risk of neurodegenerative diseases
Date:
August 07, 2018 09:53 AM
Neurodegenerative diseases like Alzheimers are becoming more and more common in the United States, and pose an increasing risk to aging populations. A recent study has identified gut microbes as one of the causes of these diseases - a huge breakthrough in the field, and one with significant implications for how we view our brain's health. These microbes release chemicals that can change the nature of the brain. It's a finding that shows that caring for our digestive health can be one of the most important steps to preventing diseases like Alzheimers, later on. Key Takeaways:
"They reached their conclusions after examining gut microbes and changes in mouse models of multiple sclerosis. They discovered the compounds produced by the breakdown of tryptophan cross the blood-brain barrier and activate an inflammatory pathway that can limit neurodegeneration." Read more: https://www.naturalnews.com/2018-07-30-gut-microbes-play-a-significant-role-in-the-central-nervous-system.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5695) Experts Weigh in on Safe Cannabis Consumption
Date:
January 19, 2018 07:59 AM
As cannabis legalization spreads across the US, the debate is in for what is safe consumption. While any drug should be done with limitations, those limitations, especially for amount and duration need to be developed, as well as how you should properly interact with the drug. While there is no worry about a "THC overdose" they still need to determine what the long term detrimental effects are of the drug as well as which is better for the body. Should you smoke it? Vaporize it? Ingest it? Is it better in its pure THC form or is there benefit from the plant. More studies will follow. Key Takeaways:
"For the thousands of Vermonters who choose to use recreationally, what will the equivalent of a "drink responsibly" campaign for cannabis look like?" Read more: https://www.sevendaysvt.com/vermont/experts-weigh-in-on-safe-cannabis-consumption/Content?oid=11969442
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5495) Could CBD oil be used for bone disorders ?
Date:
September 28, 2017 12:14 PM
Cannabidiol oil, or CBD oil, has the potential for use as a treatment of osteoarthritis, inflammatory joint pain, and other related joint pains. CBD is valuable in this regard because it has the potential to, by attaching to CBD1 and CBD2 receptors present in the joints of mammals, reduce the inflammation and pain that patients experience. However, there is still a need for more research. CBD is confirmed to have the potential to solve the issues of pain and inflammation suffered by those with OA, and possibly even prevent OA from developing at all, but as of yet there has been no testing of CBD as a treatment for OA and joint pain. Key Takeaways:
"In musculoskeletal disease models, systemic administration of CBD suppressed the progression of collagen-induced arthritis by reducing inflammatory cytokine production." Read more: http://mmjreporter.com/could-cbd-oil-be-used-for-bone-disorders-31091.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5288) Pomegranate Seed Oil to Treat Metabolic Syndrome, Inflammation and Diabetes
Date:
August 05, 2017 07:14 PM
Pomegranate seed oil can be used to treat metabolic syndrome, inflammation and diabetes too. Pomegranate contains many different bio active compounds. Pomegranate seed oil is very good for our overall health. This was reported by several studies in human as well as animal models. Various reports indicate that PA is beneficial for different conditions like obesity, and diabetes and inflammation as well as metabolic syndromes. Studies are needed in order to in order to determine how to make most of the beneficial components of the pomegranate during processing. Read more: Pomegranate Seed Oil to Treat Metabolic Syndrome, Inflammation and Diabetes
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5091) The Health Benefits of Matcha Tea
Date:
July 25, 2017 09:14 AM
A major tv network has come out with a story about matcha. This is a green tea that has been ground into powder. Matcha has become a favorite with models and is offered at Starbucks. The article explored whether the item is really healthy or just another "in" thing that will fade over time. The article cited a study which showed matcha resulted in higher levels of alertness. Another study found matcha reduced stress in mice. Several photos and links are included. Key Takeaways:
"Mind you, green tea is caffeinated and matcha is an even more caffeinated form of green tea, containing approximately 34mgs of caffeine where traditional green tea averages at about 30mgs and an espresso has around 60mgs, but the L-theanine in matcha prolongs its mood-boosting effects" Read more: https://www.nbcnews.com/better/health/much-ado-about-matcha-it-really-healthy-ncna783886?cid=public-rss_20170720
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5031) War on Weed: Detroit shuts down 167 cannabis retailers, even though Michigan legalized medical marijuana
Date:
June 15, 2017 12:14 PM
About half of Detroit's citizens are registered for cannabis use ( nearly a quarter of a million). This warrants a large cannabis industry. Nonetheless, about 167 are going to close and only 5 are operating legally, due to changes in regulation as a consequence of interference by the state of Michigan. The changes include pot-free zones which are required for the establishment of cannabis and zoning permissions. This does not include the almost 300 dispensaries operating illegally. Key Takeaways:
""Though many medical marijuana businesses continue to operate at their own risk, officials are confident that they will have successful models to follow the day cannabis becomes legal in Michigan"" Read more: http://www.naturalnews.com/2017-06-12-war-on-weed-detroit-shuts-down-167-cannabis-retailers-even-though-michigan-legalized-medical-marijuana.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4837) CBD and Your Brain
Date:
June 14, 2017 12:14 PM
CBD is found in cannabis sativa otherwise known as marijuana and is useful in treating many neurological disorders such as depression, anxiety and even epilepsy. Unlike THC, CBD has no psychoactive effects. CBD has been found to protect brain cells from harm in neurodegenerative diseases like Alzheimer's. Best of all CBD has literally zero side effects! Research shows that CBD has opened many doors leading to a cure for depression and anxiety. CBD has been proven to reduce swelling, pain and inflammation caused by injury and arthritis even when applied topically. CBD may not be a medical cure all but it has been proven to be a very useful tool in the treatment of many medical conditions. Key Takeaways:
"When various brain injuries from animal models were examined, it was found out that CBD boosted a number of viable brain cells." Read more: https://www.cashinbis.com/cbd-and-your-brain/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4831) Strawberries contain powerful anti-cancer medicines and have now been scientifically shown to prevent breast cancer
Date:
May 29, 2017 04:14 PM
In the war on breast cancer, we need all the help we can get, and now scientist have discovered it in the epitome of spring, strawberries. Scientist discovered that strawberries are high in a compound called phenolic that inhibited growth, cellular division and reproduction, particularly in the A17 group classification of tumors. Strawberry concentrates, which amounts to between 10 and 15 strawberries, lysis cell walls in the tumor, killing it. This can bring new hope to millions that suffer with this aggressive cancer. Key Takeaways:
"We have shown for the first time that strawberry extract, rich in phenolic compounds, inhibits the proliferation of breast cancer cells in in vitro and in vivo models." Read more: http://www.naturalnews.com/2017-05-01-strawberries-contain-powerful-anti-cancer-medicines-and-have-now-been-scientifically-shown-to-prevent-breast-cancer.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4725) 'Good' bacteria is potential solution to unchecked inflammation seen in bowel diseases
Date:
March 16, 2017 01:44 PM
Valuable microscopic organisms might be the way to turning around a cycle of gut irritation found in certain fiery inside ailments, College of North Carolina Lineberger Far reaching Tumor Center scientists have found. Scientists found that including back a sort of advantageous microscopic organisms that ordinarily develops in the gut can help end this cycle, recommending another treatment for incendiary inside ailment. The two most basic fiery entrail infections, Crohn's illness, and ulcerative colitis influence an expected 1.6 million individuals in the Unified States, as indicated by the Crohns and Colitis Establishment of America. They trust their discoveries could conceivably prompt to medications for individuals with fiery gut illnesses with diminished NLRP12 expression. You can focus on the irritation that downstream of NLRP12 with mitigating medications, or you could simply nourish the creatures particular microscopic organisms that advantage, and it causes a move that made them less defenseless to the ailment. Key Takeaways:
"NLRP12 has been known to suppress inflammatory signals to prevent an overactive immune response. But an analysis uncovered low levels of NLRP12 in twins with ulcerative colitis, but not in paired twins without the disease. And in mouse models that lacked this protein, they found higher levels of inflammation in the colon." Read more: https://www.sciencedaily.com/releases/2017/03/170313135055.htm
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4177) Your brain could sabotage your New Year's weight loss goals
Date:
January 14, 2017 12:59 PM
Have you already quit your New Year's diet? If so, it may not be your fault - it may be a matter of evolution. British researchers have discovered that our ancestors, because food was often scarce, became binge-eaters whenever a new source of food appeared. Unfortunately, in today's world where food is almost always available, we still have those primitive cravings. Gaining weight? Blame the cavemen. Key Takeaways:
"A new Model suggests it's not a failure of willpower, or even of our conscious minds, but rather something much deeper in our evolutionary history." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3782) How inflammation interferes with the formation of new bone material
Date:
December 14, 2016 10:22 PM
One suffers from autoimmune inflammation when the immune system takes healthy cells to be foreign and fights them. This disease causes abnormal changes and growth in body organs; it can affect many or just one body tissue. Autoimmune inflammation usually runs in families. The main cause of the disease is not known, but theories usually rotate on factors like chemical irritants, drugs, environmental irritants and virus. Autoimmune inflammation interferes with the process of bone formation as the chemicals released by body cells increase blood flow resulting in warmth or swelling of the infected part. This swelling causes irritation of the joints and the bones cartilage wears down swelling the joint lining. With patients with autoimmune inflammation, there will be the erosion of the cartilage and the bone. It causes weakening of the bone which is as a result of deterioration of the bone structure and low bone mass. This increases the risks of fractures as the bone becomes more fragile. It affects the bone formation by reducing muscle forces on the bone which can cause paralysis. From the activation of cells and immune system, there is a production of inflammatory cytokines which induce the bone loss. This is because it causes local cartilage degradation and thus inhibits bone formation.Bone reModeling highly depends on the balanced action between bone-resorbing and the osteoblast, in this process, an inflammatory process that would target the joint will affect the structure of the bone. This will result in impaired function of the bone and the destruction of bone tissue. OPC generally helps to lower the blood pressure, protect the brain, stop deep vein thrombosis, prevent oxidative and stop inflammation. The seed extract reduces anything damaging the joints and helps in immune regulation. They help stop the symptoms of collagen-induced arthritis. It helps in building of the backbone. It acts as antibacterial agents, preventing inflammable infections. Inflammation can also be prevented through exercises and stopping obesity. Modification of the diet and consumption of supplements will also help avoid inflammation.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3645) Reverse osteoporosis naturally for strong and healthy bones
Date:
December 10, 2016 10:59 AM
Want to know how to keep your bones healthy and avoid osteoporosis? You should! There are three lifestyle changes you can make to avoid and even reverse osteoporosis naturally: eat foods that support your bones, use specific natural remedies, avoid these common things, and exercise. It's never too late to begin protecting your bones! Key Takeaways:
"Dairy, like cheese and ice cream in particular, is acidic, whereas your body is better off with food with a more alkaline pH. When you eat a lot of dairy, your body pulls calcium from your bones to try to neutralize the acidity." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3613) Wintergreen Oil- Used For Pain, Arthritis, Headaches and More
Date:
February 26, 2014 09:06 AM
What is wintergreen
Generally wintergreen has been utilized for respiratory conditions however the essential utilize as of late has been as a part of liniments and treatments for bulky issues, for example, lumbago, sciatica, neuralgia, myalgia, and so on it is known for its capability to diminish bone agony.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3038) How calcium can Help Prevent Bone Loss
Date:
November 08, 2013 09:59 AM
Intake a lot of calcium too, as there are two sources of calcium in your body: via your diet and from your bones. It is the latter that is dangerous. Your body will absorb calcium from the bones if there isn't enough in the body. This calcium is really difficult to replace. Intake a diet with magnesium too. It helps in absorption of calcium. If there is excess calcium in the body, one could suffer from arthritis as it will collect in the soft tissues.References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2884) Can Vitamin D-3 Improve Your Health?
Date:
February 28, 2013 02:59 PM
Vitamin D-3 or cholecalciferol, an active form of D vitamin, plays a huge role in bone reModeling and normal calcium balance. Sunlight is responsible for the conversion of cholesterol to vitamin D on the skin but when exposure to sunlight do not always synthesize sufficient amounts, this D vitamin can be obtained from various sources. The recommended daily dose of this vitamin is 1000 IU for adults or more if there is a deficiency. As mentioned, insufficient amount of such vitamin from sunlight can be supplemented by various sources such as the following: - Fatty fishes like salmon, mackerel, sardines and tuna - Dairy products, such as milk, soy milk, yogurt and cheese - Grains - Other food products like egg, beef liver and orange juice Insufficient amount of this vitamin can also be supplemented through the consumption of multivitamins, which can provide approximately 400 IU of vitamin D-3. However, take note that higher doses, such as the ones with up to 50,000 IU, require a prescription from your doctor. You can find D-3 in dosages as high as 10,000IU at a health food store. Health Benefits of Vitamin D-3 This type of vitamin D can definitely improve one's health with all the benefits it can provide. This fat-soluble vitamin is responsible for the proper absorption of calcium in the body, thus making it essential for the bones. Insufficient amount of this essential vitamin in the body can result to brittle bones and other health problems. On the other hand, sufficient amount of this essential vitamin can provide you lots of health benefits, such as the following: - Bone Health: as mentioned, this fat-soluble vitamin facilitates the proper absorption of calcium from foods and the reabsorption of essential minerals by the kidneys. Apart from that, it also boosts the absorption of phosphorous, which is also essential for the health of the bones and prevents various diseases, such as rickets and osteomalacia. - Immune System: this vitamin is also beneficial for the body's immune system. According to various studies conducted, it can also help prevent autoimmune disorders from developing and is useful in treating inflammatory diseases. - Neuromuscular System: vitamin D-3 can enhance the functions of the neuromuscular system, as well as protect the body against muscle weakness due to the process of aging. - Weight Loss: if combined with a healthy diet and regular exercise, this can also help promote weight loss. It helps assimilate foods properly and regulates the levels of blood sugar. - Skin: this fat-soluble vitamin is also beneficial for the skin, as it contains natural anti-inflammatory properties. It helps control various inflammatory diseases, such as psoriasis, speeds up the healing process of wounds, alleviate skin lesions due to photodermatitis and lichen planus, reduce itching and rejuvenates the skin. - Depression: the connection between depression and this D vitamin is still unclear. However, a certain study has shown that this insufficient amount of this essential vitamin in the body can increase the risk of depression in men and women. It can also result to hyperparathyroidism where depression is the most prevalent system. Apart from all these, vitamin D-3 and its supplements can provide the body with lots of other health benefits. It can regulate blood pressure and protect the body against cardiovascular diseases, as well as from various types of cancers. Have you had your vitamin D-3 today?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2828) Are There Herbs And Vitamins For Pain?
Date:
December 29, 2012 10:17 AM
Everyone at one point or the other suffers some pain which could be of different kinds. We usually go for prescription drugs or at times, over-the-counter pain relievers. These drugs, however, have many side effects and do cause numerous health damages if used for a long period of time. Thus, it is much better to turn to natural pain relievers, such as herbs and vitamins. Most herbs and vitamins for pain are used as food; therefore, do not have any side effects. This is however not the case in painkillers which are made from synthetic hormones, chemicals, and so on. Herbal pain relievers. Turmeric: Turmeric is popularly used in Southeast India for cooking. Turmeric has curcumin, a very powerful ingredient which aid to fight against chronic inflammatory ailments. Thus, turmeric is usually employed with some other herbs to relieve pain. Ginger Root: Ginger root is a commonly used herbal remedy since it contains warming properties and helps to enhance blood circulation. It is essential in treating arthritis associated pains, backache and menstrual cramps. It's also used to treat sore throat. It is both analgesic and anti-inflammatory. Valerian Root: This is used for chronic pain relief and as a skeletal relaxant. It may be used also for the treatment of trauma, cramps, shingles, headaches, insomnia, neuralgia, and stress. It possesses antispasmodic properties and is also a sedative. Arnica: This is a homeopathic pain reliever and is believed to be particularly essential in the treatment of bruising and soft tissue injuries. It helps to alleviate overall sprains and muscle pain. It may be applied externally as a preventive measure to avoid injury prior to racing or exercising. Thus, it is seen to be applied topically and care must be taken so as not to apply it on a broken or open skin. Vitamins for Pain Relief Vitamin D: This is a unique vitamin since its main source is being exposed to UV light. A deficiency in this nutrient is widespread and a popular cause of chronic pains. As a matter of fact, a vitamin D deficiency significantly raises the risk of common women's pains. In a study, vitamin D deficiency was shown to raise risk of chronic pain, particularly in women, by over 50%. Aside from sunlight, other sources of vitamin D are mushrooms, shellfish, fatty fish and fortified orange juice. Vitamin E: This is a potent antioxidant which protects nerves and joints from damages which may cause pain. In a recent research, it was discovered that vitamin E supplements lower nerve pain. Vitamin E-rich diets are walnuts, peanuts, wheat germ, corn and kiwi. B complex Vitamins: These include many water-soluble vitamins, such as riboflavin, thiamine and folic acid. In a chronic pain animal Model, it was discovered that high amounts of B-complex vitamins reduced pain significantly. B-complex vitamin supplements can be found in a number of supplement stores. Dietary sources are vegetables, whole grains, fortified cereals and fruits. Vitamin C: This is an antioxidant just like vitamin E and protects nerve cells from damage. A scientist known as Paul E. Zollinger discovered that vitamin C supplements helped in reducing pain in wrist fractured patients. Foods rich in Vitamin C are broccoli, bananas, mangoes and oranges.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2791) What Are Some Interesting Calcium Facts?
Date:
October 01, 2011 11:13 AM
Do you know what contains your teeth and bones? Have you ever wondered what makes your muscles move, your body respond to stimulus and your heart beat? If yes, then you might need to explore some of these wonders of the body. As we know for a fact, the body is composed of thousand of cells that need substances such as nutrients for its biological processes and survival. One of these nutrients is the mineral called Calcium which is one of the main chemical substances that make those mentioned above possible. Calcium is considered to be the most in terms of quantity among all the other minerals inside the body. It is needed for the contraction of muscles so that movement will be achievable. It also influences the constriction and dilation of blood vessels thus helping in the regulation of blood pressure. Aside from its effect on the muscles and blood vessels, calcium also affects the nerves and plays a significant role in the transmission of nerve impulses so that appropriate response to external stimulus will be possible. Moreover, as an ion, calcium is also required in the process of intracellular signaling and is an important chemical for hormone secretion. Physiologically, the calcium level in the blood to support these functions is only less than 1 % of the total calcium inside the body. Almost 99 % of the body’s calcium is stored in the bones and teeth for structural and functional support, as well as calcium reservoir. If the blood level of calcium decreases, the bones will be demineralized and calcium will be released into the blood stream, thus, normalizing serum calcium level. Even if the body has reached its maximum growth, the bones will continually undertake reModeling. This process involves regular resorption and deposition of calcium minerals into the new bone. Bone reModeling varies from person to person depending on the individual’s age. Bone mineralization or formation exceeds bone demineralization during the growing years of puberty and adolescence. On the other hand, during early and middle adulthood bone deposition and resorption are usually balanced. Furthermore, women on their post menopausal age exceed bone mineralization or formation. Their bodies constantly extract calcium from bones to compensate blood levels of calcium. This is one of the reasons why post menopausal women have a higher risk of osteoporosis. Therefore, recommended dosage for calcium is higher for women at 50 years and older and men at 70 years and older. Another interesting fact about Calcium is that it requires Vitamin D which is also a nutrient that can be naturally produced by the body and can also be supplied by the diet. On the other hand, foods which can lessen the absorption rate of calcium are the foods which are high in oxalic acid and phytic acid. Examples of foods rich in oxalic acid are spinach, sweet potatoes and beans, while those that contains high phytic acid are wheat bran (not wheat products), seeds, nuts and soy. Caffeine, alcoholic beverages, phosphorus, sodium and proteins can decrease the absorption of calcium, thus increasing elimination through the urine, feces and sweat.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2471) Does Boron Really Help Improve Bone Health?
Date:
July 01, 2011 11:06 AM
Boron and Bone Health
Boron is now widely considered an essential mineral, though its daily value is still a matter of debate. The physiological roles of this chemical element in the human body were unknown in the first half of the 20th century, but in recent years scientific research has proven that it is necessary for the calcium metabolism and vitamin D utilization, both of which significantly contribute to overall bone health. There has not been any figure set in the dietary reference intake for boron largely owing to the fact that its nutritional importance has not been discovered until recently. As a result, important data on the safety of boron intake as a dietary mineral remains under investigation. Nonetheless, the scientific community is convinced that the presence of boron is required for many different metabolic processes. Plants need relatively higher amounts of boron to survive. It follows that plant-based foods are very good sources of dietary boron whereas animal products have negligible amounts of this element. This chemical element was first noted to have a positive effect on joint health. The studies that followed have been observed that boron supplements alleviate symptoms of osteoarthritis in human trials. Promotes Bone Health Concentrations of boron in the synovial fluid and joint cartilage help determine the health of joints and bones. It has been reported that people who have higher amounts of elemental boron rarely develops degenerative joints diseases like osteoarthritis and symptoms of joint pain. Also, epidemiologic studies have shown that populations noted for healthy consumptions of boron have lower incidence of arthritis. More recent studies have shown that boron intake is directly proportional to bone density. For one, it has been documented that supplementation of boron has an impact on bone strength in patients with osteoporosis. Clinical trials have produced very promising results as far as the treatment of bone loss is concerned. There is very good scientific evidence that boron supplements are superior to placebo. Inhibits Bone Resorption The skeletal system is the primary depot for minerals in the human body. Chemical elements obtained from the diet are stored in the bones or otherwise utilized by tissues and organs. In particular, more than half of the overall body concentrations of calcium, potassium, and magnesium are found in the bones, which are constantly reModeled to draw minerals out in response to the needs of body tissues. The process of bone resorption is responsible for releasing the minerals from the bones into the blood. On the other hand, the process of bone resorption takes care of building bone tissue. If consumptions of dietary minerals are insufficient, resorption exceeds formation, as is the case with osteoporosis. The presence of boron promotes mineral retention in the bones, thereby increasing bone mass and density. If you are experiencing osteoporosis, give boron a try!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2356) Lutein 20mg (FloraGlo)
Date:
September 26, 2008 03:49 PM
Maintains Healthy Visual Function* It has been well established that lutein is present in high concentrations in the retinal tissue of the human eye. However, a study was conducted in human volunteers to determine whether taking lutein in supplement form actually increased the density of the carotenoid pigments present in the macula. In this study of eight individuals, researchers estimated the density of the macular pigments prior to having each individual take 10 mg of lutein daily in supplement form for 12 weeks. Plasma lutein concentrations were measured at 4-week intervals. During the first four weeks of the study, plasma levels increased five-fold from pre-supplement measures, and then remained at this level for the duration of the study. It was also shown that, due to increased deposition of lutein in optical tissues, macular pigment density increased by an average of 5.3% at the 4-week mark, and continued to increase until the duration of the study.1 A study was also conducted to investigate the possible role of specific nutrients in protecting the lens of the eye against aging, a risk factor for compromised visual function. The study was comprised of 376 individuals aged from 18 to 75. Of the nutrients measured, it was found that the lenses of individuals with higher concentrations of lutein and zeaxanthin showed less of an effect from the aging process. The investigators concluded that these carotenoids might play a protective role in supporting the maintenance of healthy vision.2 The Age-Related Eye Disease Study (AREDS) was a landmark study of the effects of diet and antioxidant supplementation on eye health. The study enrolled over 3500 subjects aged 55 to 80 years who were followed for approximately 6 years. Among the data collected in this multi-faceted study was a self-administered Food Frequency Questionnaire (FFQ). The AREDS Report No. 22 examined the data from the FFQs and determined that, of the nutrients evaluated, only lutein and zeaxanthin were directly related to maintaining eye health with statistical significance3. These findings corroborated similar results of an earlier multi-center study published in the Journal of the American Medical Association that also found that those with a higher intake of lutein and zeaxanthin maintained healthier eye function.4 These promising results have spurred the design of a second major clinical trial (AREDS2), which is currently enrolling participants to study the impact of supplemental xanthophylls (FloraGLO® Lutein and zeaxanthin) and other nutrients on age-related eye health.5 In addition, a double-blind placebo controlled trial was performed in ninety individuals who had signs of compromised visual function. Individuals were divided into three groups and received either 10 mg FloraGLO® lutein, 10 mg FloraGLO® lutein plus a multivitamin/multimineral formulation, or placebo for 12 months. In both the FloraGLO® lutein and FloraGLO® lutein plus other nutrients groups, improvements were seen in mean eye macular pigment optical density, visual acuity and contrast sensitivity. No improvements were noted in the placebo group.6 These results demonstrate FloraGLO® lutein’s beneficial effect on maintaining healthy visual function. Newly published research has demonstrated that lutein and zeaxanthin supplementation may enhance visual performance under glare conditions. Forty healthy subjects took daily doses of 10 mg FloraGLO® Lutein plus 2 mg zeaxanthin for six months. They were evaluated for changes in macular pigment, glare disability and photostress recovery at the onset of the study, and at 1, 2, 4 and six months. After six months, subjects experienced an average increase in macular pigment optical density (MPOD) of 39% compared to baseline, and all but two participants experienced some increase in MPOD. This increase in MPOD was also directly related to measured improvements in visual performance after exposure to bright light, as well as photostress recovery.7 This study suggests another way in which lutein and zeaxanthin can help support optimal visual function in healthy individuals. Potent Antioxidant Protection* Most of the beneficial effects of lutein are ascribed to its potent free radical scavenging abilities. It is well-known that lutein is a carotenoid related to beta-carotene and possesses antioxidant activity against a number of reactive oxygen species.8 More direct evidence for the free radical scavenging activity of lutein is found in studies of its effects on human lens epithelial cells. Cell cultures were exposed to ultraviolet light after pretreatment with lutein or alpha-tocopherol. Both nutrients were found to reduce ultraviolet-induced damage to lens epithelial cells. However, lutein was shown to have significantly higher photoprotective activity than alpha-tocopherol9 demonstrating its potential as a high-powered antioxidant. A further review of the mechanisms of lutein in conferring a protective role reveals evidence for its antioxidant activity in various body tissues. Lutein has been shown to be an effective antioxidant in vitro as well as in experimental Models of a number of body systems.10 Supports Healthy Skin* A recent randomized, double blind, placebo-controlled study has demonstrated the positive effects of oral and topical administration of lutein on skin health parameters (surface lipids, hydration, photoprotective activity, skin elasticity and skin lipid peroxidation). Forty female subjects were divided into four treatment groups. Treatment options included oral administration of 5 mg of FloraGLO® Lutein twice daily or placebo and topical administration of 50 ppm FloraGLO® Lutein twice daily or placebo. Each treatment group received either an active oral treatment with a placebo topical treatment, a placebo oral treatment with an active topical treatment, both active treatments, or both placebo treatments. Statistically significant improvements were seen in all five parameters tested in all treatment groups compared to the group receiving only placebos. The greatest overall improvements were seen in the group receiving both active oral and topical treatments, while lesser but still significant improvement was seen in both the active oral only and the active topical only groups. Additionally, oral administration of lutein conferred superior photoprotective activity (as measured by skin surface redness after exposure to ultraviolet light) and prevention of lipid peroxidation (as indicated by levels of malondialdehyde in skin lipids after exposure to ultraviolet light) than either topical lutein or placebo.11 Diverse Cinical Benefits* Evidence from various experimental trials suggests that lutein may play a protective role on the circulatory and cardiovascular systems. Its antioxidant activity may also extend to the heart, skin, lungs and blood vessels, making it a nutrient with diverse clinical benefits. Lutein possesses the ability to promote the health of many body tissues.12 Suggested Adult Use: One softgel daily with food, or as directed by a health care professional. Does Not Contain: milk, egg, wheat, sugar, sweeteners, starch, salt, or preservatives. Scientific References 1. Berendschot TT, et al. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Invest Opthalmol Vis Sci. 2000 Oct; 41(11): 3322-6. 2. Berendschot TT, et al. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Arch Opthalmol. 2002 Dec; 120(12): 1732-7. 3. Age-Related Eye Disease Study Research Group. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol. 2007 Sep; 125(9): 1225-32. 4. Seddon JM, et al. Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration. JAMA. 1994 Nov; 272(18):1413-1420. 5. www.nei.nih.gov/neitrials/viewStudyWeb.aspx?id=120. Clinical Studies Database. Age-Related Eye Disease Study 2 (AREDS2). Last Updated 2/28/2008. Viewed 5/15/2008. 6. Richer S, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr; 75(4): 216-230. 7. Stringham JM and Hammond BR. Macular pigment and visual performance under glare conditions. Optom Vis Sci. 2008 Feb; 85(2):82-8. 8. “Lutein and Zeaxanthin”. PDR Health. www.gettingwell.com/drug_info/nmdrugprofiles/nutsupdrugs/lut_0164.shtml 9. Chitchumroonchokchai C, et al. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. J Nutr. 2004 Dec; 134(12): 3225-32. 10. Krinsky NI. Possible biologic mechanisms for a protective role of xanthophylls. J Nutr. 2002; 132: 540S-542S. 11. Palombo P, et al. Beneficial Long-Term Effects of Combined Oral/Topical Antioxidant Treatment with the Carotenoids Lutein and Zeaxanthin on Human Skin: A Double-Blind, Placebo-Controlled Study. Skin Pharmacol Physiol. 2007; 20: 199-210. 12. Mares-Perlman JA, et al. The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview. J Nutr. 2002; 132: 518S-524S.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1901) Fight Osteoporosis With Minerals To Build Bones And Improve Quality Of Life
Date:
April 02, 2008 11:06 AM
Bone consists predominantly of collagen and calcium phosphate. The collagen provides the connective framework for bone that is hardened by the calcium phosphate, and without healthy bones, your quality of life would be significantly reduced due to bone breakage. That is why it is essential to supplement this framework with the vitamins and minerals needed to maintain a good bone density at those periods in your life when bone density is liable to deteriorate. This begins to happen between the ages of 30 and 35 and in women and accelerates during the menopause, when your ovaries stop producing the hormone estrogen that is necessary for the maintenance of healthy bones. Through time, your bone mass drops creating first a condition known as osteopenia, or reduced bone mass, and then osteoporosis, when your bones become brittle, porous and very prone to fractures. Before we look at what can be done to reduce your chances of developing osteoporosis, lets have a close look at how bone develop so that it will be easier to understand the remedial action that can be taken. Calcium is the most common mineral in the body, and the vast majority is in the bones and teeth. Phosphorus is also essential for healthy bones because as stated earlier, the bone consists of collagen that is hardened by calcium phosphate. The two main uses of phosphorus are in bone structure and animal metabolism, since phosphates are also essential for the vast majority of the energy-production chemical reactions within your body. Calcium has other functions within the body other than bone, however, including exchange of fluids within and between cells, the maintenance of your heartbeat and in blood clotting. Vitamin D is necessary to help calcium be absorbed from your diet, through the membranes of the duodenum. More calcium is absorbed there than in the small intestine, and the calcium is also most available to the body when it is in a water-soluble form. In fact, the reason that stones form in your kidney for example, is that the calcium is rendered insoluble through the formation of calcium oxalate from the oxalic acid in foods such as rhubarb and soy. High fat diets can also slow down the absorption of calcium. Estrogen plays a significant part in bone physiology, and is an important factor in the maintenance of bone density in women. Bone is living tissue, and is constantly being absorbed and reModeled throughout life. The part played by estrogen is to maintain a proper balance between the osteoclasts, the cells that reabsorb bone tissue, and osteoblasts, the cells that form new bone tissue. When estrogen is deficient, this balance is lost and rather than bone formation and resorption occurring constantly, they take place in spurts so that first an area of new bone will be formed, then resorption will occur some weeks later, resulting in a structure where there are cavities between areas of bone. With time, these cavities will increase and weaken the integrity of the bone structure. However, that is not the whole story. The effect of estrogen is to limit the active period of osteoclasts so that the areas of bone resorbed into the body are relatively small so that the removed bone cavity can easily fill up with new bone by the osteoblasts, which are invigorated by estrogen. When estrogen is deficient, not only is the activity of the bone-forming osteoblasts reduced, but the bone-absorbing osteoclasts activity is not regulated, and they form deeper holes in the bone structure than the osteoblasts are able to fill. The net result is bone loss, with more bone being reabsorbed than is being formed. The end result of all this is spongy bone tissue with many tiny hole and also with larger areas of missing bone. Eventually this passes a critical point and the bone fractures during normal use. A simple jump from one step to another can fracture a bone at its weakest point, such as at the hip joint where the neck of bone is thinner. Not everybody is at the same risk, and there are certain risk factors that you should be aware of, each of which could increase the chances of you developing weak bones. The condition particular affects white or Asian women, and those who have a small frame. If you smoke and drink an excessive amount of alcohol, you will also be more prone to osteoporosis, although exercise can help you to avoid it. An inadequate intake of calcium and vitamin D will also contribute, and magnesium is an essential part of strong bone development. The U.S. Department of Agriculture has carried out surveys that indicate American women to be taking only 50% of the calcium recommended to maintain a healthy bone density. However, it is not only dietary calcium that is needed for the formation of bone, but also magnesium and boron, and vitamin D also helps with the absorption of calcium in the gut. If you are on steroids then they can render you more prone to brittle bone disease. Unfortunately the symptoms of osteoporosis do not become evident until there has been a significant amount of bone loss, which is why post menopausal women, and those over 65, should have a bone density scan (DXA test). It is important to understand that osteoporosis is not a disease as such: you cannot ‘catch’ it, but it develops as the result of a gradual reduction in the minerals that maintain the density of your bone structure. Your diet is important in helping you prevent bone loss and osteoporosis later in life, and your lifestyle is also important. Reducing your daily alcohol intake will certainly help, and cigarette smoking further retards the activity of the bone-creating cells. Calcium and vitamin D supplements will help, but do not restrict yourself only to these.
If you want to maintain proper bone density through and beyond the menopause stage of life, you should take a balanced supplement that contains a combination of vitamins and minerals needed to maintain a healthy balance between natural bone loss and regeneration. There is more to it that only calcium and vitamin D, and a balanced supplement takes this out of your hands. You can rest in the knowledge that you are doing the best for your body and its bone density.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1734) Learn about Bone Health!
Date:
April 20, 2007 12:43 PM
Bone Health Approximately 44 million American women and men aged 50 and older have osteoporosis (severe bone loss) or osteopenia (mild bone loss), with women being affected about twice as often as men. At least 1.5 million fractures of the hip, vertebra (back or neck), or wrist occur each year in the United States as a result of osteoporosis, and the annual cost of treating this disorder is nearly $14 billion and rising. Unfortunately, the toll in human suffering and loss of independence is even greater. In this issue of Ask the Doctor, we will discuss the risk factors for osteoporosis and some key nutrients you can add to your diet that can minimize bone loss and reduce your chances of developing this disease. Q. What are the risk factors for osteoporosis? A. Small body frame, underweight, Caucasian or Asian race, a sedentary lifestyle, cigarette smoking, excessive alcohol or caffeine intake, high intake of carbonated beverages (especially colas), and having other family members with osteoporosis all increase personal risk of developing the disease. Certain medical conditions, including diabetes, celiac disease, hyperthyroidism, rheumatoid arthritis, chronic obstructive lung disease, hyperadrenalism, and hyperparathyroidism, are all associated with an increased risk of osteoporosis. Some medications increase the rate at which bone is lost; these include drugs prescribed for the treatment of seizures, drugs used for blood thinning, steroids such as prednisone, aluminum-containing antacids, and loop diuretics (furosemide {Lasix}). Q. Isn’t bone loss just a normal consequence of aging? A. Although bone mass normally declines after the age of 35, bone loss severe enough to cause fractures after just minor trauma (such as bump or fall) seems to be a relatively new phenomenon. Osteoporosis was rare in the late 19th century, and it was not until around 1920 that the condition began to attract attention among doctors. Since that time, the percentage of people who develop osteoporosis has continued to increase. For example, the age-adjusted prevalence of osteoporosis in Q. Can osteoporosis be prevented? A. Engaging in regular weight bearing exercise, avoiding excessive consumption of alcohol and caffeine, and quitting smoking will slow the rate of bone loss. Eating adequate, but not excessive, amounts of protein also enhances bone health. In addition, a growing body of research has shown that supplementing with various vitamins and minerals may not only help prevent, but in some cases actually reverse, bone loss. At least 15 different nutrients have been found to play a role in bone health. Q. What type of calcium is best? A. For most people, calcium salts are absorbed about the same, between 30% and 40% of the administered dose. People who low stomach acid (hypochlorhydria) should not use calcium carbonate, because that form of calcium is absorbed poorly in the absence of stomach acid. Calcium phosphate may be preferable for many older people, because phosphorus is necessary for normal bone formation, the phosphorus intake of older people is often low, and calcium supplements inhibit the absorption of phosphorus. Also, calcium bound to phosphorus is the form in which calcium in the bone is stored, and it has a much greater bone activity than other forms. Q. How much vitamin D is needed to promote strong bones? A. Because vitamin D is produced when the ultraviolet rays from the sun hit skin, people who stay out of the sun, wear sunscreen, or live in a northern latitude (such as Boston or Seattle) where less ultraviolet light reaches the skin, are at increased risk of vitamin D deficiency. In addition, aging decreases a person’s ability to synthesize vitamin D in the skin. Results from five research trials on vitamin D found that supplementation with 700-800 IU of vitamin D per day decreased the number of hip fractures by 26%, but 400 IU per day was ineffective. In addition to enhancing bone health, vitamin D improves nerve and muscle function in older people, thereby reducing their chances of falling down. Supplementation of elderly women with 800 IU of vitamin D per day has been shown to decrease the number of falls by about 50%. Q. Is that much vitamin D safe? A. The Food and Nutrition Board of the Q. Why would nutrients besides calcium and vitamin D is important? A. Bone is living tissue, constantly reModeling itself and engaging in numerous biological functions. Like other tissues in the body, bone has a wide range of nutritional needs. The typical refined and processed American diet has been depleted of many different vitamins and minerals, some of which play a key role in promoting bone health. Not getting enough of one or more of these micronutrients may be and important contributing factor to the modern epidemic of osteoporosis. In addition, supplementing with calcium may cause a loss of magnesium, zinc, silicon, manganese, and phosphorus, unless these nutrients are also provided. Q. What nutrients besides calcium and vitamin D promote healthy bones? A. Magnesium, zinc, copper, manganese, vitamin K, boron, strontium, silicon, folic acid, vitamin B6, vitamin B12, phosphorus, and vitamin C have all been shown to play a role in bone health. Following is a brief description of the role that each of these 15 nutrients play in building healthy bones. Calcium: A component of the mineral crystals that make up bone. Vitamin D: Enhances calcium absorption, prevents falls by improving nerve and muscle function. Magnesium: Important for bone mineralization (accumulation of minerals which form bones). Magnesium deficiency is associated with abnormal bone mineral crystals in humans. In an open clinical trial, magnesium supplementation increased bone mineral density by an average 5% after 1-2 years in postmenopausal women. Copper: Laboratory research has found that copper promotes bone mineralization and decreases bone loss, and that osteoporosis can develop if the diet is deficient in copper. Western diets often contain less copper than the amount recommended by the National Academy of Sciences. In a 2-year double-blind trail, copper supplementation reduced bone loss by 90% in middle-aged women, compared with a placebo. Zinc: Like magnesium, zinc is important for bone mineralization, and also has been shown to decrease bone loss. Low dietary zinc intake was associated with increased fracture risk in a study of middle-aged and elderly men. The zinc content of the diet is frequently low; a study of elderly low-income people found they were consuming only half the Recommended Dietary Allowance for this mineral. Manganese: Plays a role in the creation of the connective-tissue components of bone. Manganese deficiency in laboratory tests resulted in low bone mineral density and weak bones. Manganese deficiency may be associated with the development of osteoporosis. Boron: Supports creation of bone-protecting hormones such as estrogen, testosterone, and DHEA. Boron supplementation prevented bone loss in experimental studies. In human volunteers consuming a low-boron diet, boron supplementation decreased urinary calcium excretion by 25-33%, a change that may indicate reduced bone loss. Silicon: Plays a role in the synthesis of the connective-tissue components of bone. Silicon deficiency has been associated with bone abnormalities. In an observational study, higher dietary silicon intake correlated with higher bone mineral density. In a clinical trial, administration of an organic silicon compound increased bone mineral density of the femur (or thigh bone) in postmenopausal women. B vitamins (folic acid, vitamin B6, and vitamin B12): These three B vitamins have been shown to lower blood levels of homocysteine, a breakdown product of the amino acid methionine. An elevated homocysteine concentration is a strong and independent risk factor for fractures in older men and women. Homocysteine levels increase around the time of menopause, which may explain in part why bone loss accelerates at that time. In a 2-year double-blind trial, supplementation of elderly stroke patients with folic acid and vitamin B12 reduced the number of hip fractures by 78%, compared with a placebo. Strontium: This trace mineral is incorporated into bone and appears to increase bone strength. It also stimulates bone formation and inhibits bone breakdown. Controlled trials have demonstrated that strontium supplementation of postmenopausal women increases bone mineral density and decreases fracture risk. Vitamin K: Best known for its effect on blood clotting, vitamin K is also required for the creation of osteocalcin, a unique protein found in bone that participates in the mineralization process. The amount of vitamin K needed for optimal bone health appears to be greater than the amount needed to prevent bleeding. Vitamin K levels tend to be low in people with osteoporosis. In randomized clinical trials, supplementation of postmenopausal women with vitamin K prevented bone loss and reduced the incidence of fractures. Q. Which form of vitamin K is best? A. Two forms of vitamin K compounds are present in food: vitamin K1 and vitamin K2. Vitamin K1 (also called phylloquinone) is present in leafy green vegetables and some vegetable oils, and vitamin K2 is found in much smaller amounts in meat, cheese, eggs, and natto (fermented soybeans). To make things a little more complicated, Vitamin K2 itself can occur in more than one form. The two most important to this discussion are menaquinine-4 (MK-4, also called menatetrenone), which is licensed as a prescription drug in Research suggests that MK-7 from natto may be an ideal form of vitamin K. The biological activity of MK-7 in laboratory studies was 17 times higher than that of vitamin K1 and 130 times higher than that of MK-4. After oral administration, MK-7 was better absorbed and persisted in the body longer, compared with MK-4 and vitamin K1. Although both have shown ability to prevent osteoporosis in laboratory research, a much lower dosage (600 times lower) of MK-7 is required, compared to MK-4, to obtain beneficial effects. Thus, MK-7 has greater biological activity, greater bioavailability, and possibly more potent effects on bone, compared with other forms of vitamin K. The potential value of MK-7 for bone health is supported by an observational study from Q. Why is strontium so important in building strong bones? A. Strontium is of great interest to bone health researchers and has been studied in very high doses. Surprisingly, lower doses are not only safer for long-term supplementation, but may in fact have a greater impact on bone health than very high doses. Too little, and bone density is impaired; too much and health may be impaired. This is a case where dosing needs to be just right for optimal impact. Therefore, until more is known, it is wise to keep supplemental strontium at less than 6 mg per day. Q. Can people taking osteoporosis medications also take bone-building nutrients? A. Because nutrients work by a different mechanism than osteoporosis drugs, nutritional supplements are likely to enhance the beneficial effect of these medications. Calcium or other minerals may interfere with the absorption of biphophonates such as alendronate (Fosamax) or etidronate (Didronel). For that reason, calcium and other minerals should be taken at least two hours before or two hours after these medications. Also, it is always best to discuss the supplements you are using with your healthcare practitioner to create an integrated health plan. Final thoughts… Bone health ramifications extend beyond osteoporosis and fractures. Bone health is essential for freedom of movement, safety, comfort, independence and longevity. Weak bones do not heal well – sometimes they never heal at all. Osteoporosis-related fractures rob us of our mobility and consign thousands of Americans to walkers and wheelchairs every year. In fact, 40% of people are unable to walk independently after a hip fracture, and 60% still require assistance a year later. The most terrible consequence of fractures related to osteoporosis is mortality. The impairment of the ability to move around freely can cause pneumonia and skin damage leading to serious infections. It is estimated that suffering a hip fracture increases the risk of dying almost 25%. Making bone health a priority now will allow you to reap health dividends for many years to come.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1523) D-Ribose Powder Benefits!
Date:
April 10, 2007 11:57 AM
Supports normal heart function*
A significant amount of in vitro, animal and human research suggests benefits of ribose on heart function.* Studies have shown that ribose supplementation can enhance cardiac energy levels and support cardiovascular metabolism.* Ribose has been shown in clinical trials to enhance the recovery of heart muscle ATP levels and improve myocardial function following exercise.
Studies suggest that ribose supplementation can increase the tolerability of the cardiovascular system to exercise-induced fatigue.1 In one study, twenty men underwent treadmill exercise tests on two consecutive days to confirm the onset of fatigue secondary to exercise. The participants were then randomized to the treatment group or a placebo group. The groups received either four doses of 15 grams of D-ribose (60 grams/day total) or the same amount of placebo each day. After three days of treatment, another treadmill test was performed. The time it took to reach the specified level of fatigue was significantly greater in the ribose group than in the placebo group.
Another study investigated the ability of ribose to support healthy heart function and quality of life.2 In a randomized, crossover design study, fifteen individuals were given 5 grams three times a day of either D-ribose or placebo. Each treatment period lasted three weeks. In patients receiving ribose, echocardiography demonstrated enhancement of heart function, reflecting a “more efficient relaxation phase of the heart”. Participants also had a significant improvement in their subjective quality of life scores compared to placebo.
Scientists suggest that suboptimal heart function is a result of the heart requiring more energy to function properly. Ribose supports the heart’s enhanced energy requirements, promoting optimal heart function. It does so by enhancing the stores of high-energy phosphates in heart tissue. These intermediates are necessary for the production and resynthesis of ATP. A double-blind crossover study in which 12 individuals were randomized to receive either ribose or dextrose (both administered as 5 grams three times daily for three weeks, followed by a 1-week washout period and crossover of treatments for three additional weeks) suggested significant enhancements in normal cardiac function during the period of ribose supplementation.3
Perhaps one of the more useful illustrations of the potential for ribose to support heart function comes from a study in which 20 rats received a continuous infusion of ribose for 24 hours (control rats received an infusion of saline). The hearts were then explanted (as they would be for heart transplants) and placed in preservation solution that was enriched with ribose for 4 hours. ATP levels were measured from tissue biopsies and revealed that 10 of the ribose-treated hearts had ATP levels higher than 12.3 micromoles per gram whereas saline-treated hearts (controls) had lower ATP levels, with 20% showing levels below 10 micromoles per gram of tissue. This provides support for the hypothesis that ribose may enhance the preservation of ATP levels in cardiac tissue, promoting normal heart function.4
Further animal studies have shown that ribose significantly enhances heart function after experimentally induced cardiac depression. Rats were injected with isoproterenol (a drug that stimulates sympathetic nervous system function) and had their abdominal aorta constricted to induce depression of heart function and reduce cardiac ATP levels. The decrease in ATP was primarily responsible for the depression of heart function. Continuous infusion of ribose for 24 hours replenished ATP concentrations to normal levels and normalized heart function in these animals.5
Ribose may strengthen and support the body’s crucial antioxidant defenses*
Ribose may support the body’s innate antioxidant mechanisms while promoting an antioxidant effect of its own. Intense exercise and other strenuous activity can induce the production of free radicals. Preliminary studies suggest that ribose can attenuate some of the effects of oxidation seen after performance of intensive exercise.
One small human study indicated that ribose administered at a dose of seven grams before and after a bout of cycling exercise may reduce free radical production.6 Seven volunteers ingested either ribose or placebo both before and after intense exercise. Markers of lipid peroxidation, including malondialdehyde, significantly decreased in the ribose-supplemented group, while increasing in the control group. The results of this study indicate a possible effect of ribose in supporting antioxidant activity.
Supports healthy energy levels in heart and muscle tissue*
After bouts of intense exercise, ATP levels have been shown to decrease by an average of 15 to 20%.7 The amount of ATP stored in the muscle is limited and so the body must have the potential to rebuild ATP stores. ATP is the fuel necessary for the integrity and function of a cell. In addition, several studies have found correlations between ATP content and heart function.1 Research that was also alluded to above suggests that ribose stimulates ATP synthesis and supports heart and muscle function by enhancing ATP levels in cardiac and muscle tissue. D-ribose is an essential building block for the synthesis of ATP through the pentose phosphate pathway.
The results of ribose supplementation enhancing ATP levels in muscle are evidenced by studies suggesting beneficial effects on anaerobic performance. In a randomized, placebo-controlled crossover study assessing the effects of acute ribose supplementation, participants receiving the ribose supplement had increases in mean power (a measure of average overall muscular strength output during the sprint) and peak power (a measure of the highest muscular strength output during the sprint) when undergoing a series of cycle sprints.8 While this effect was not noted in all of the six short cycling sprints that the participants underwent, the study does illustrate the potential benefits of ribose on ATP production and, secondarily, on enhancing exercise performance.
A second placebo-controlled trial investigated the effects of four weeks of ribose-supplementation (10 grams /day) on male bodybuilders. Of the 20 participants who were recruited, twelve completed the study. Each subject participated in a heavy-resistance training program designed to increase skeletal muscle mass. The effects of ribose on body composition (body weight, body fat, lean body mass, fat mass, and bone mineral content) were also assessed. The results suggested that ribose increased total work capacity and bench press strength compared to placebo, without altering body composition.9
Supports energy recovery after exercise*
Animal studies have suggested that the administration of ribose after exercise increases the rate of adenine salvage by five to seven-fold in muscle tissue7, supporting energy recovery after exercise. When ATP is utilized by muscle tissue, the degradation products include adenine nucleotides (Adenine is one of two purine bases that is a component of DNA). Adenine is recycled to synthesize DNA, and the salvage of adenine within the muscle tissue is crucial to energy recovery. Studies have shown that the presence of adequate ribose concentrations is the rate-limiting step in the purine salvage pathway. Therefore, increased adenine salvage could potentially help in the recovery and regeneration of ATP after intense bouts of activity.
A study investigated the effect of oral intake of ribose on the synthesis of AMP, a precursor to ATP.10 Participants performed intense cycle training for seven days. They then received either ribose (at a concentration of 200 mg/kg body weight, which is equivalent to 14 grams per day for an average 70 kilogram male) or placebo three times a day for the following three days. Exercise tests were performed again on day 4. Muscle biopsy samples were taken before the first training session, immediately after, and again five hours, 24 hours, and 72 hours after the last training session. No differences were seen in exercise performance between the groups. The intense exercise caused the ATP levels in muscle to decrease in both groups. However, at 72 hours post-exercise, the ribose group exhibited a much higher ATP level than the placebo group. The muscle levels of critical building blocks for ATP, including total adenine nucleotides (TAN) and inosine 5’-monophosphate (IMP), were also significantly higher in the ribose group compared to the placebo group at 24 hours after exercise. Ribose-supplementation was shown to enhance the resynthesis of ATP after intense exercise.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Safety
Caution: Insulin-dependent diabetics and pregnant women should consult their physician before use.
Suggested Adult Use: Take 1 or 2 scoops mixed in water, juice or other beverage two times per day. May be taken with or without food.
Scientific References
1) Pliml, W., von Arnim, T., Stablein, A., Hofmann, H., Zimmer, H., Erdmann, E. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. The Lancet. 1992;340:507-510.
2) Omran, H., Illien, S., MacCarter, D., St. Cyr, J.A., Luderitz, B. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. The European Journal of Heart Failure. 2003;5:615-619.
3) Illien, S., Omran, H., MacCarter, D., St. Cyr, J.A. Ribose improves myocardial function in congestive heart failure. FASEB Journal 2001;15(5): A1142
4) Muller C., Zimmer H., Gross M., Gresser U., Brotsack I., Wehling M., Pliml W. Effect of ribose on cardiac adenine nucleotides in a donor Model for heart transplantation. Eur J Med Res. 1998 Dec 16;3(12):554-8.
5) Zimmer H.G. Normalization of depressed heart function in rats by ribose. Science. 1983 Apr 1;220(4592):81-2.
6) Seifert, J.G., Subudhi, A., Fu, M., Riska, J.J. The effects of ribose ingestion on indices of free radical production during hypoxic exercise. Free Rad Biol Med 2002; 33(Suppl 1) S269.
7) Zarzeczny, R., Brault, J.J., Abraham, K.A., Hancock, C.R., Terjung, R. Influence of ribose on adenine salvage after intense muscle contractions. J Applied Physiology. 2001;91:1775-1781.
8) Berardi J.M., Ziegenfuss T.N. Effects of ribose supplementation on repeated sprint performance in men. J Strength Cond Res. 2003 Feb;17(1):47-52.
9) Van Gammeren, D.V., Falk, D., Antonio, J. The effects of four weeks of ribose supplementation on body composition and exercise performance in healthy, young, male recreational bodybuilders: a double-blind, placebo-controlled trial. Current Ther Research. 2002;63(8):486-495.
10) Hellsten, Y., Skadhauge, L., Bangsbo, J. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology. 2004;286:R182-R188.
-- Buy Ribose at Vitanet at a Discount
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1510) Bio-Allers – All Natural Allergy Relief
Date:
March 12, 2007 02:50 PM
VitaNet is pleased to offer you the bio-allers ling of homeopathic allergy remedies. For over 15 years, bioAllers advanced allergy medicine has provided relief to allergy sufferers everywhere. Allergies have become a common condition for a growing number of adults and children, affecting an estimated 50 million people in the United States. Every year, approximately 5.4 million unattended school and work days are lost due to allergies. Everything from the air we breathe to the food we eat can cause an allergic reaction, resulting in a number of annoying and often debilitating symptoms. Approximately 35 million people suffer from seasonal allergic rhinitis, commonly known as hay fever, which is triggered by such allergens as week, tree, and grass pollens. Approximately 16.7 million office visits to health care providers each year are attributed to allergic rhinitis. In addition to seasonal allergies, a growing number of people suffer from household allergies, including mold spores, yeast and dust mites. Avoidance of these reaction-causing substances is the most effective treatment for these allergies. However, that is not always easy or possible to do. In four double-blind clinical trials, homeopathic allergen preparations allersodes were shown to relieve symptoms and reduce allergic reactions. Treatment groups were shown to have from 33% to 83% greater symptoms improvement than the placebo group. The most recent study showed that those patients who had been taking the allersodes continued to show reduced allergy symptoms for up to five weeks after the last does was taken. bioAllers is a leader in the research and development of allergy relief and is the #1 homeopathic allergy relief brand. bioAllers also delivers specific allersodes that work with the body to deliver targeted symptom relief. bioAllers relieves allergy symptoms of sneezing, runny nose, itchy and watery eyes, congestion and headache without side effects or drowsiness. References: Janet zand, L.Ac., OMD, Allen N. Spreen, MD CNC, James B LaValle, RPH, ND, Smart Medicine for Healthier Living, 1999, P. 291-293. Reilly D.T., Tylor M.A., McSharry C., Aitchisin T.C., Is Homeopathy a Placeby Response? Controlled Trial of Homeopathic Potency with Pollens in Hayfever as Model, The Lancet, October 18, 1986, 881-886. Poitevin B., Review of Experimental Studies in Allergy, British Homeopathic Journal, April 1998, Vol. 87, PP. 89-99.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1493) Revita
Date:
March 08, 2007 12:27 PM
Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product. Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class. To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules. Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth. Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available. Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects. In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls." In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded: • The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls. • 78.9% of subjects showed an increased mean value of hair diameter. • "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness." Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth phase) and telogen (resting phase) of the hair follicle. When the anagen phase is prolonged, and the telogen phase is shortened, increased hair growth results. Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings: • Total Number of Hairs: Significantly Increased • Total Number of Terminal Hairs: Significantly Greater • Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher • Hair Follicle Activation: Intensive In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials. Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue reModeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss. Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area. The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp. Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles. Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E. Spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth. Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing. Ketoconazole - Topical ketoconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that ketoconazole exhibits other methods to its anti-hair-loss effect. One such theory of ketoconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, ketoconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial. If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% ketoconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months. Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with ketoconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen phase increased by 6.4% and 8.4% respectively during the study. The results are similar to a previous study done on 2% prescription strength Ketokonazole where it was shown that use of 2% ketoconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo. Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion. After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier. Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss. MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM. The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes. MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications. Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness. The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone. According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss. The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study. Carnitine Tartrate - L-Carnitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate. Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate. The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased. Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft. Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids. Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth. L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications. The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth. Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day. In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing. Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic. Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth. Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle. Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss. After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week. This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted. Q. Is Revita safe ? A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as Ketoconazole have been tested in clinical studies and have been shown safe. Q: Can I use hair sprays, mousses, gels, etc.? A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita. Q: Can I have my hair colored or permed while using Revita ? A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita. Q: What is SLS/SLES free ? A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health. Q: Can I blow dry my hair after using Revita ? A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita. Q: Who is a candidate for Revita ? A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately. Q: What type of results should I expect with Revita ? A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment. Q. Does Revita have any systemic side effects ? A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically. Q. Does Revita work for women? A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair. Q. I am using other topical treatments. Can I use Revita at the same time ? A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair. Q. Do I need to use Revita for a long time ? A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp. Q: Is stress a factor in hair loss? A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1480) Benefits - Supports joint function and tissue health*
Date:
December 11, 2006 03:46 PM
To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage. Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis. 1,2,3 Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued. 3 Promotes optimal joint comfort, function and flexibility* Boswellia serrata (Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal Models without known side effects. 4 Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesis in vitro, promoting a healthy balanced production of these components of the immune system.5 Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.6 Other trials lend further support to Boswellia’s ability to promote healthy joint function.4,6,7 Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.8 Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response.9 Curcumin also demonstrates in vitro inhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.9,10,11 Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.12 Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results. Bioperine-Nature’s Absorption Enhancer Boosts Nutrient Absorption* Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.13 Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.14 Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. 15 These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability. Sustained Release – For lasting joint comfort and convenient dosing To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day. Safety Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.
Scientific References 2. Tapadinhas M.J., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68. 3. Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion 1982; 8(3):145-149. 4. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7. 5. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R., and Ammon, H.P.T. (1992) Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146. 6. Boswellia serrata. Alternative Medicine Review Monographs – Volume One. 2002. 7. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5. 8. Majeed, M., Badmaev, V., Shivakumar, U., Rajendran, R. Curcuminoids: Antioxidant Phytonutrients. 1995. Piscataway, NJ: NutriScience Publishers. 9. Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae). The Protocol Journal of Botanical Medicine, Autumn 1995:43-46. 10. Rao, S., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol. 1997;49:105-7. 11. Ramsewak, R.S., DeWitt, D.L., Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308. 12. Deodhar, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of curcumin (diferoyl methane). Indian J Med Res 1980;71:632-34. 13. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of Ethnopharmacology 1981;4:229-232. 14. Bioperine®–Nature's Bioavailability Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa Corporation, Piscataway, N.J. 15. Shoba, G., et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998;64(4):353-6.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1438) Which Calcium is Best?
Date:
October 17, 2006 03:52 PM
Customers walking into a health food store today are faced with a vast array of calcium supplements. They might ask: which one should I pick? Which one is best? Not easy questions to answer. All calcium forms will accomplish the same task: providing your body with a nutrient that it needs to build healthy bones and teeth; however, which form of calcium has the features that you want in a calcium supplement? Looking at shelves of calcium products is kind of like shopping for a car; there are many makes and many Models—some are basic and others are more sophisticated. Fortunately, there are many forms of calcium to satisfy your needs. Like the car lot, a health food store offers many options; therefore, you have to select a calcium product that consumers will feel confident in taking regularly and that will provide the most benefit. Some consumers have done research and will come armed with information. They have already made choices based on advertising, word-of-mouth or an article they have read. They already know the form of calcium they want, be it a “Ferrari” or a “Ford.” If the client doesn’t have a specific preference: asking these basic questions will help in the selection process: 1. Do you prefer tablets, capsules, softgels, liquid or powder?
2. Do you have high or low stomach acid?
3. Do you have absorption issues?
What is calcium? Calcium (Ca) is one of the most important minerals found in our bones and teeth—99 percent of body calcium is found there. But the calcium molecule does not like to travel alone and, in its more basic state, it comes bounded to carbon (C), Oxygen (O), and/or hydrogen (H) molecules or in more complex form, it is bonded to organic or amino acids that act as stabilizing carriers. On most labels, the amount of calcium listed actually indicates the pure or elemental calcium because it is that amount of the calcium that is deemed important to our daily supplementation, not the complex of the materials with which it is bonded. Where does calcium come from? Other than the calcium found in bone, the only natural form of calcium found in nature is calcium carbonate, a calcium molecule bonded to one molecule of carbon and three molecules of oxygen (CaCO3). One of the most common minerals on the face of the earth, calcium carbonate is called calcite, aragonite or vaterite by geologists. In its geological form, it constitutes approximately four percent, by weight, or the earth’s crust. Commercial sources of calcium carbonate used to make supplements are: limestone, dolomite, oyster cell, egg shell, coral and sea water (have you ever seen that white deposit left by hard water? That’s mostly calcium carbonate). Calcium carbonate is the starting material for all other forms of calcium supplements. From this starting material, calcium can be reduced to more concentrated forms, such as oxide or hydroxide or it can be chelated (bonded) to organic acids and amino acids to help support enhanced absorption. Lets look more closely at the different forms of calcium that are available as supplements. Calcium Oxide (CaO): this form is 71 percent elemental calcium and is also called “lime” commercially. This is one of the oldest and most inexpensive forms of calcium used in a variety of commercial applications and it is occasionally used in supplements where space and price are a factor. It sometimes can be found in inexpensive mass market calcium/mineral combinations or multivitamin/mineral products and in a unique algal calcium from Japan. Unfortunately, CaO is a strong alkali that may cause stomach distress, which is why it isn’t often used in health food supplements. Calcium Hydroxide (CaHO): at 54 percent elemental calcium, it is the next highest source of elemental calcium and is also known commercially as “slaked lime.” It is used where space is an issue. Although it is also a strong alkali, it is more stable than calcium oxide. It is most often used as a component of multi-mineral formulations or in addition to other forms of calcium (i.e., calcium citrate) to provide potency where space is an issue. It is not often used as a single ingredient in health food supplementation. This is for people who want a high dosage of calcium from a minimum amount of pills in multi-mineral formulas. Calcium Carbonate (CaCO3): at 40 percent elemental calcium, it is the most widely used form of calcium in single ingredient calcium supplements as well as combination supplements. Inexpensive and an abundant source of elemental calcium, it is the only form of calcium found in nature outside of bone. It is the primary form of calcium used in the mass market and in antacid products. This is for people who have high stomach acid and who need a buffering type of calcium. Also for people who want a high dose of calcium in a minimum amount of pills. Calcium Citrate: at 21 percent elemental calcium, it is one of the most popular forms of calcium supplements in the health food market as well as the mass market. This calcium salt does not lower stomach acid as much as calcium carbonate. This calcium salt is usually recommended for people who have low stomach acid, have had stomach surgery or who need a form of calcium that will not lower their stomach acid further. Calcium Gluconate and Lactate: these two forms of calcium are high soluble. Since the amount of elemental calcium is much lower (9 percent and 13 percent respectively), they are used more often in powder form and mixed with liquids or food. When mixed in a beverage, the calcium is already dissolved and is ready to be absorbed. This is the best calcium salt for people who have overactive bowels, who have trouble swallowing pills or who don’t like the taste of pre-formed liquid calcium supplements. These calcium powders can be mixed in juices or smoothies or added to food as they are virtually tasteless. Calcium Orotate and Asporotate: In the mid 20th century, Dr. Hans Nieper, a German scientist, advanced a theory that orotic and aspartic salt forms of calcium are transported directly to cell membranes for better absorption. The Solaray brand developed an asporotate formula, which combines three organic acids: aspartic acid (-Asp), orotic acid (-oro) and citric acid (-tate) into one product. The asporotate formula has become one of the most popular calcium formulas and is exclusive to the Solaray brand. This product is for customers who appreciate the idea of combining the enhanced absorbability of three organic acids into one. Aspartate and citrate are also part of the krebs (energy) cycle and are natural to the body’s metabolic systems and, according to Neiper, calcium Orotate and Aspartate are mineral transporters that enter into the cells to facilitate enzymatic actions rather than being extra-cellular. For people who believe that intracellular calcium is of importance, calcium Orotate and asporotate may be good choice. Calcium Hydroxyapatite: this is another “natural form of calcium usually as a mineral ash form bovine source bone. Bone meal is also a form of calcium from bovine bone. These forms of animal derived calcium are for customers who want a source that is closest to their own bone matrix. Not for vegetarians. Calcium Amino Acid Chelates (*HVP): this form is calcium carbonate bonded (Chelated) to a form of amino acid complex such as whole rice concentrate or other grain source. This form is for customers who want the additional bioavailability of amino acids. Calcium AEP: Another form of calcium endorsed by Dr. Hans Nieper who theorized that calcium would cross the cell membranes more readily when it was combined with phosphatidyl ethanolamine or Amino Ethanol Phosphate (AEP), a nutrient found in nerve sheaths. This highly specialized form is for very educated customers who are proponets of Hans Niepers theory. So, which form is best? Calcium, like cars, comes in a variety of forms. Isn’t it wonderful that we have so many choices? The point is, there is no best one, there are only individual choices. Although we have our favorites, taking a calcium supplement, regardless of which one it is, should:
Our primary concern when choosing a calcium supplement should be to provide our body with the right amount of calcium daily so that our skeleton and teeth can maintain proper mineralization and strength as the cells continuously break down and rebuild. The type of calcium complex we prefer is entirely up to us. *HVP = Hydrolyzed Vegetable Protein
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1411) Remifemin symptomatic relief, scientifically supported*
Date:
August 26, 2006 02:41 PM
Remifemin
Symptomatic Relief, Scientifically Supported*
The only RemiSure black cohosh
Unique to Remifemin® - Exclusive standardized isopropanolic black cohosh extract, subject of over 90 scientific papers.
Proven Effective – The most clinically studies natural intervention for menopausal symptoms with over 40 years of use worldwide*
Safe – Completely hormone free
Efficacy
Safety
Relevant Reports and Guidelines
Responding to the need for alternative menopausal symptom relief*
Natural, Safe alternative to HRT for menopausal symptoms*
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VitaNet Recommends Remifemin
Lit source: Enzymatic therapy. *this statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treate, cure, or prevent any disease.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1358) Lutein to fight age-related macular degeneration!
Date:
February 27, 2006 05:53 PM
Lutein: The Antiordinary Antioxidant Lutein belongs to a class of compounds known as carotenoids. Carotenoids in general are yellow, orange, or red pigments responsible for many of the colors of the foods we consume each day. To date, over 600 carotenoids have been identified in nature, but are only produced by plants, algae and bacteria leaving humans and animals to consume carotenoids in the diet. Forty to fifty carotenoids are consumed in the typical US diet, but only 14 have been detected in the blood, indicating a selective use of specific carotenoids by the body. Lutein is one of these carotenoids found in the blood and has been increasingly associated with eye health over the last decade. Lutein’s role in eye health In the human eye, lutein is concentrated in the center of the retina in an area known as the macula. Lutein is deposited in the macula through the lutein we consume in out diet or through supplements. This area is responsible for human central vision and is colored intensely yellow due to high concentrations of lutein. Lutein is thought to be beneficial for eye health by reducing damage in the eye in two ways: 1) by absorbing blue light (blue light is thought to increase free radical formation in the eye) and 2) by acting as an antioxidant, reducing damage in the eye caused by free radicals. Leading carotenoid researchers believe these functions may lead to a reduced risk of age-related macular degeneration (AMD) and cataracts. Age-related macular degeneration Macular degeneration is the leading cause of blindness in the USA in those over 65. twenty-five and thirty million people are afflicted worldwide and currently there are no effective treatments for the disease. The disease has two forms known as dry and wet AMD. Ninety percent of AMD cases diagnosed are the dry form. In dry AMD, also referred to as early AMD, debris deposits under the center of the retina (known as the macula) interfering with its normal function. Parts of the macula atrophy, causing the central vision to slowly become dimmer or more blurry. Wet age-related macular degeneration, also known as late AMD, often develops in areas where dry AMD exists. Abnormal blood vessels grow and leak blood and fluid under the macula, causing scarring, which leads to rapid loss of central vision. Dr. Joanna Seddon published one of the first studies demonstrating a link between lutein intake and AMD risk in 1994 (1). This epidemiological study compared the risk of developing AMD to nutrient intake and showed a significant reduction in risk for developing AMD as lutein intake reached 6mg per day (57% reduction in risk). Since the Seddon study, researchers have shown that increasing dietary lutein intake raises blood levels of lutein as well as levels of lutein in the eye (2). Bone et al. demonstrated that eyes with higher levels of lutein were less likely to be afflicted with AMD (3). The latest clinical trial that investigated lutein’s role in AMD is known as the lutein antioxidant supplementation trial (L.A.S.T) (4). This study evaluated the effects of lutein supplementation for one year in 90 veterans diagnosed with dry AMD. Supplementation with lutein in these subjects significantly increased the concentration of lutein in the macula. Improvements in visual function were also detected with lutein supplementation. Glare recovery, visual acuity, and contrast sensitivity were all improved. This study continues to build on clinical evidence that the dry form of AMD may be responsive to changes in nutrition. Cataracts A cataract is a natural clouding of the lens, the area of the eye responsible for focusing light and producing clear, sharp images. For most people, cataracts are a natural result of aging. Currently in the US, cataracts are the second leading cause of blindness in the elderly behind AMD. Lutein is the major carotenoid that has been identified in the human lens asn is thought to provide similar benefits to the leans that are seen in the retina. Two large epidemiological studies consisting of >70,000 women (age 45-71) and >30,000 men (age 45-75) compared the risk of cataract extraction to nutrient intake (5,6). Similar to AMD, a significant reduction in risk of cataract extraction was associated with lutein intakes of 6mg per day (20% reduction in risk). Besides cataract extraction, higher levels of lutein consumption have been associated with a decreased risk of cataract development and improvements in visual acuity and glare sensitivity in people with age-related cataracts. Lutein consumption The richest source of free lutein in the typical US diet are dark green leafy vegetables, with the highest concentration found in kale followed by spinach. The average daily lutein intake is low, average between 1-2 mg/day. Currently there is no recommendations of the dietary guidelines for Americans 2005 (9 servings of fruits and vegetables every day) you would consume between 4 and 8 mg of lutein a day (7). Epidemiological evidence, animal Models, and clinical data have indicated levels of 6-10 mg a day may be necessary to realize the health benefits associated with lutein consumption. By continuing to increase our intake of lutein, we begin to ensure the optimal health of our eyes. References: Seddon et al. (1994) dietary carotenoids, vitamin a, c, and e, and advanced age-related macular degeneration. Eye disease case-control study group. JAMA. 272: 1413-20. Bone et al. (2000) Lutein and zeaxanthin in the eyes, serum and diet of human subjects. Exp. Eye Res. 71: 239-45. Bone et al. (2001) Macular pigment in donor eyes with and without AMD: a case-control study. Invest. Ophthalmal. Vis Sci. 42: 235-40. Richer et al. (2004) Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-relaged macular degeneration: the veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 75: 216-30. Brown et al. (1999) A prospective study of carotenoid intake and risk of cataract extraction in the US men. Am. J. Clin. Nutr. 70: 517-24. Chasen-Taber et al. (1999) A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am. J. Clin. Nutr. 70: 509-16 HHS/USDA. Dietary Guidelines for Americans 2005. //www.healthierus.Gov/dietaryguidelines/CDC. National health and nutrition examination survey data 2001-2002. //www.cdc.gov/nchs/about/major/nhanes/nhanes01-02.html Brandon lewis, Ph.D. is the applied research and Technical services manager at kemin health, L.C. in des moines, iowa. His responsibilities include the initiation and management of laboratory projects pertaining to the inclusion and analysis of kemin ingredients in vitamins and dietary supplements, as well as developing new applications and prototypes that include kemin ingredients. Prior to joining kemin, Brandon was enrolled at the university of Florida where he received his Ph.D. in Nutritional Science from the department of Food Science and Human Nutrition.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1235) Pomeratrol™ Fact Sheet
Date:
December 19, 2005 09:09 AM
Pomeratrol™ Fact SheetNeil E. Levin, CCN, DANLA 9/28/04USER: Those needing antioxidant protection; People with a family history of cell growth abnormalities; Anyone concerned with aging KEY INGREDIENT(S): Pomegranate fruit standardized extract 200 mg. (Punica granatum) containing 80% total polyphenols, including 40% Ellagic acid, Resveratrol (100% trans-resveratrol) 20 mg. from a blend of Japanese knotweed root extract (Polygonum cuspidatum) and grape skin extract (Vitis vinifera) POTENTIAL BENEFITS: Ellagic acid is a polyphenol compound found in raspberries, strawberries, pomegranates, and other fruit. It has been shown to normalize cell death of abnormal cells, a process called apoptosis. This enhances the body’s cell growth control system by providing an important plant substance. It may bind to DNA to prevent damage to this all-important genetic material. This is a key step in preventing cell damage that leads to signs of aging. The American Cancer Society says that research in animal and laboratory Models has found that ellagic acid inhibits the abnormal growth of certain cells. Research at Ohio State University indicates that berries typically contain a few milligrams per ounce of ellagic acid, the actual level varying quite a bit from variables such as species, variety and growing conditions. Resveratrol is an antioxidant compound that is a phytoestrogen, or plant estrogen, which is protective of hormone-mediated cells in the body. Resveratrol is a potent antioxidant if stabilized. If not stable, it may quickly metabolize out of the body. This compound is believed responsible for some of the beneficial effects of moderate red wine drinking on the cardiovascular system. Resveratrol is also considered to be beneficial to smokers’ lung tissue if it is stabilized to last long enough in the system to be transported there. Resveratrol is also an inhibitor of the COX-2 inflammatory enzyme and encourages cell death (apoptosis) of abnormally growing cells. In insect experiments resveratrol even repaired DNA, leading to a longer life for healthy cells even as it helped get rid of unhealthy cells. Again, this ability to protect cells and help the body rid itself of abnormal cells is a key factor in preventing signs of aging. One liter of red wine contains between 1.5 and 3 mg. of resveratrol. OTHER IMPORTANT ISSUES: Resveratrol is a difficult substance to stabilize. Because of the difference between resveratrol produced in the oxygen-poor environment in red wine and the form of resveratrol in unstabilized supplements, it has long been thought that resveratrol supplements were not very effective in comparison with wine. Knowing the importance of how a resveratrol supplement is metabolized, Now’s scientific staff has recently developed a special technique of stabilizing this compound in order to have an antioxidant effect closer to drinking a good glass of wine. While both trans and cis forms of resveratrol are naturally occurring, most of the recorded health benefits are attributed to the trans form. Now’s Pomeratrol provides trans-resveratrol. DOSE: One capsule per day. Resveratrol has been used safely in studies at doses equivalent to 500 mg./day. COMPLEMENTARY PRODUCTS: Other antioxidants and plant compounds: Vitamin C, pycnogenol, grape seed extract, and alpha lipoic acid.
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. There are some indications that resveratrol is a mild anticoagulant ("blood thinner"), and it also may help keep blood vessels to remain open and flexible. Caution should be used by those on blood-thinning drugs. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1039) Nattokinase Fact Sheet
Date:
December 08, 2005 05:14 PM
Nattokinase Fact SheetNeil E. Levin, CCN, DANLA 8/8/05LIKELY USERS: People seeking to support heart health and healthy circulation.1-6 KEY INGREDIENTS: Nattokinase, an enzyme STRUCTURE/FUNCTION USE: Nattokinase is an enzyme isolated from Natto, a traditional Japanese fermented soy food. Natto has been consumed safely for thousands of years for its numerous health benefits. More recently, both clinical and non-clinical studies have demonstrated that Nattokinase supports heart health and promotes healthy circulation. Each serving of NOWR Nattokinase provides 2,000 FU (Fibrinolytic Units) to help keep already healthy levels of blood clotting factors within a normal range. 1-6 ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: An assay of 2,000 FU (Fibrinolytic Units) is equivalent to 160 IU on the Urokinase assay. The FU assay measures Nattokinase activity by using the fibrin plate method and measuring the absorption of released low-molecular weight substances.7 NOW Nattokinase is made from non-GE (non-genetically engineered) bacteria (Bacillus subtilis var. Natto) grown on non-GE soybeans and standardized on a base of non-GE, corn-derived maltodextrin. SERVING SIZE & HOW TO TAKE IT: Take one vegetarian Vcap once or twice a day between meals (without protein). COMPLEMENTARY PRODUCTS: Vein SupremeTM, Tru-E Bio ComplexTM, Pycnogenol®, garlic, and cayenne CAUTIONS: None. SPECIFIC: People with blood coagulation disorders or who take anticoagulant (“blood thinning”) medications (including aspirin) should consult a physician before use. Do not take if prone to bleeding. Unlike some other brands, NOWR Nattokinase contains no Vitamin K (K1 or K2), which would enhance clotting. GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:
1. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S (1995) Thrombolytic effect of nattokinase on a chemically induced thrombosis Model in rat. Biol Pharm Bull 18(10):1387-1391
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1002) Triphala Fact Sheet
Date:
December 08, 2005 04:09 PM
Triphala Fact SheetNeil E. Levin, CCN, DANLA 6/30/05LIKELY USES: Antioxidant Colon Cleansing, Detoxifying, Digestive, Liver and bile health KEY INGREDIENTS: Triphala 500 mg, in a combination of fruit powders and extracts MAIN PRODUCT FEATURES: Triphala is a combination of three fruits (Harada, Amla, and Behada) that has been used in Ayurvedic herbalism for thousands of years. Triphala's historical use as a digestive cleanser and tonifier has been backed up with numerous modern scientific studies demonstrating the positive effects of its component herbs on the gastrointestinal tract. In addition, Triphala has been shown to be a potent antioxidant, protecting cells against the damaging effects of free radicals. May help to dispel worms. Mild-acting internal cleansing; supports liver and gastrointestinal function ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: NOW offers the first - and only - Triphala supplement to combine the fruit powders (400 mg) with the extracts (100 mg) of the fruits (doses given per tablet, there are three tablets per serving). Authorities like Dr. Andrew Weil consider Triphala to be a superior bowel tonic, rather than a laxative, with its benefits increasing over time. Laxatives typically are habit-forming and do not enhance normal body elimination of wastes; this is not the case with (moderate doses of) Triphala. This formula is suitable for vegetarians and is offered in tablet form. SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, every three tablets provide 1,200 mg. (1.2 gram) Triphala powder and 300 mg. (0.30 gram) Triphala extract. Both the powder and the extract provide the three fruits in equal ratios, by weight. Take one to three servings per day, between meals. COMPLEMENTARY PRODUCTS: Fiber sources (psyllium, pectin, etc.), Detox Support, Plant Enzymes, Virgin Coconut Oil, Dr. Verghese Liver Formula, Bentonite Powder, Probiotics (GR-8 Dophilus, 4x6 Acidophilus, etc.), Electrolytes (minerals) CAUTIONS: none PRODUCT SPECIFIC: Contraindicated during pregnancy and lactation; avoid during menstruation; not appropriate for the very young or very old or the convalescent. GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems. Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES: Abraham S, Kumar MS, Sehgal PK, Nitish S, Jayakumar ND. Evaluation of the inhibitory effect of triphala on PMN-type matrix metalloproteinase (MMP-9). J Periodontol. 2005 Apr;76(4):497-502. PMID: 15857087 Al-Rehaily AJ, Al-Howiriny TA, Al-sohaiani MO, Rafatullah S. (2002) Gastroprotective effects of 'Amla" Emblica officinalis on in vivo test Models in rats. Phytomedicine 9(6):515-522. Arora S, Kaur K, Kaur S. Indian medicinal plants as a reservoir of protective phytochemicals. Teratog Carcinog Mutagen. 2003;Suppl 1:295-300. PMID: 12616620 Jagetia GC, Baliga MS, Malagi KJ, Sethukumar Kamath M. The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to gamma-radiation. Phytomedicine. 2002 Mar;9(2):99-108. PMID: 11995956 Jagetia GC, Malagi KJ, Baliga MS, Venkatesh P, Veruva RR (2003) Triphala, an Ayurvedic Rasayana Drug, Protects Mice Against Radiation-Induced Lethality by Free-Radical Scavenging. J Alt Complement Med 10(6):971-978. Jagetia GC, Rao Sk,, Baliga MS, Babu K (2004) The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro: a preliminary study. Phytother Res 18(7):561-565.
Kaur S, Michael H, Arora S, Harkonen PL, Kumar S. The in vitro cytotoxic and apoptotic activity of Triphala--an Indian herbal drug. J Ethnopharmacol. 2005 Feb 10;97(1):15-20. Epub 2004 Dec 25. PMID: 15652269 Kaur S, Arora S, Kaur K, Kumar S. The in vitro antimutagenic activity of Triphala--an Indian herbal drug. Food Chem Toxicol. 2002 Apr;40(4):527-34. PMID: 11893411 Sabu MC, Kuttan R (2002) Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol 81:155-160. Sairam K, Rao CV, Dora M, Babu K, Kumar V, Agrawal VK, Goel RK (2002) Antiulcerogenic effect of methanolic extract of Emblica Officinals: an experimental study. J Ethnopharmacol 82:1-9. Sandhya T, Lathika KM, Pandey BN, Mishra KP. Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug. Cancer Lett. 2005 May 14; [Epub ahead of print] PMID: 15899544 Tamhane MD, Thorat SP, Rege NN, Dahanukar SA (1997) Effect of oral administration of Terminalia chebula on gastric emptying: an Experimental study. J Postgrad Med 43(1):12-13. Vani T, Rajani M, Sarkar S, and Shishoo CJ. Antioxidant Properties of the Ayurvedic Formulation Triphala and its Constituents. International Journal of Pharmacognosy Vol 35, No. 5, 1997:313-3
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=995) AHCC® Fact Sheet - from Now Foods.
Date:
December 08, 2005 10:20 AM
AHCC® Fact SheetNeil E. Levin, CCN, DANLA 6/30/05LIKELY USERS: People needing increased activity of their Natural Killer cells; People seeking improved immune system response; People with a need for tissue repair; People with oxidative challenges; People seeking to increase liver function People defying aging or with a need to improve cellular integrity. KEY INGREDIENTS: AHCC® (Active Hexose Correlated Compound) MAIN PRODUCT FEATURES: AHCC® is a proprietary extract produced from specially cultivated and hybridized mushrooms. According to extensive research in humans, as well as numerous non-clinical studies, AHCC®supports immune system function through its effects on macrophages and NK (Natural Killer) Cells. NK cells and the intercellular mediators they produce are critical for the maintenance of healthy cell cycle function. AHCCR® has also been shown possess antioxidant properties, and supports healthy liver function. ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: AHCC® (Active Hexose Correlated Compound) is a patented ingredient that has been the subject of research studies. It is supported by the scientific staff in the laboratories of both NOW Foods and the raw material supplier, both of which have a mutual interest in protecting the integrity and efficacy of this product. AHCC® is a rich source of polysaccharides such as beta glucan 1,3 and activated hemicellulose produced by enzymatic modification of organic medicinal mushrooms, including shiitake. It also has been shown to support normal levels of macrophages and cytokines, further strengthening the immune system. This formula is suitable for vegetarians and is offered in Vcaps. SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, take 2 Vcaps® 3 times daily, preferably on an empty stomach. COMPLEMENTARY PRODUCTS: Antioxidants, Astragalus, Colostrum, Dr. Verghese Liver Formula, Immune Renew, Indole-3-Carbinol (I3C), Inositol Hexaphosphate (IP-6), CAUTIONS: None. PRODUCT SPECIFIC: None GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems. Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container. DISCLAIMER: Information given here may vary from what is shown on the product label because this represents my own professional knowledge and understanding of the science underlying the formula and ingredients. The information in this review should not be used as diagnosis, prescription or as a specific product claim. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES: Aviles H, Belay T, Fountain K, Vance M, Sun B, Sonnenfeld G. (2003) Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infectin in mice in the hindlimb-unloading Model of spaceflight conditions. J Appl Physiol 95:491-496. Burikhanov RB, Wakame K, Igarashi Y, Wang S, Matsuzaki S (2000) Suppressive Effect of Active Hexose Correlated Compound (AHCC®) on Thymic Apoptosis Induced by Dexamethasone in the Rat. Endocrine Regulations 34:181-188. Matsui Y, et al. (2002) Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. J Hepatol. 2002 Jul;37(1):78-86. PMID: 12076865 Matsushita K, et al. (1998) Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma. Anti-Cancer Drugs 9:343-350. Sun B, Wakame K, Mukoda T, Toyoshima A. Kanazawa T, Kosuna K (1997) Preventive Effects of AHCC® on Carbon Tetrachloride Induced Liver Injury in Mice. Nat Med 51(4):310-315. Ye SF, Ichimura K, Wakame K, Ohe M. Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci. 2003 Dec 19;74(5):593-602. PMID: 14623030 Ye SF, Wakame K, Ichura K, Matsuzaki S (2004) Amelioration by active hexose correlated compound of endocrine disturbances induced by oxidative stress in the rat. Endocr Regul 38(1):7-13.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=993) Allibiotic CF Fact Sheet
Date:
December 07, 2005 01:37 PM
Allibiotic CF Fact SheetNeil E. Levin, CCN, DANLA 03/09/05LIKELY USERS: People seeking support of the immune system and intestinal flora KEY INGREDIENTS: Allicin (“AlliSure” patented, stabilized allicin from fresh garlic); Olive Leaf Extract (Olea Europaea with 18% minimum Oleuropein content); Elderberry extract, from fruit/berry, 60:1 concentrate (equivalent to 2,500 mg. of fresh berries of Sambucus nigra); Oil of Oregano (wild oregano from Origanum vulgare) ImmunEnhancer AG (trademarked Arabinogalactan from Larch Tree, Larix occidentalis) MAIN PRODUCT FEATURES: AlliSure is the clinically tested, patented and stable form of allicin. Not allicin potential, but actual allicin. Allicin represents the immune supporting nutrients of raw garlic, and is chemically similar to penicillin, though with different physical properties. AlliSure shares garlic’s abilities to help maintain healthy cholesterol and blood pressure levels, and also has been shown to raise levels of a key T cell to enhance immune system function. Like raw garlic, AlliSure has antimicrobial properties linked to its ability to react with sulfur-containing metabolic enzymes. Allicin is also shown in studies to play a role in controlling blood sugar and abnormal cell growth. Black Elderberries have strong antioxidant properties, containing flavonoids like anthocyanidins. They have been studied in relation to inhibition of viral replication and of minor inflammations. Olive Leaf has been used as an antioxidant, cholesterol and blood viscosity regulator, and vasodilator. But its most important use has been as a way to help the body deal with undesirable organisms in the vital respiratory and intestinal areas. Oil of Oregano (wild oregano, wild marjoram) contains carvacrol and thymol, which are responsible for much of its antimicrobial activities. It also has some anti-inflammatory effects. Arabinogalactan from Larch tree bark (ImmunEnhancer AG) can help speed the immune system’s response to undesirable organisms and is often compared to Echinacea. It has also been shown to promote the growth of beneficial intestinal bacteria. ADDITIONAL PRODUCT INFORMATION: Patented and trademarked ingredients enhance quality controls and have clinical research. Rosemary Oil provides antioxidant protection for the capsule contents. Enteric coating protects the capsule from stomach acid to deliver its contents past the stomach. This helps to assure full potency and reduces the possibility of the oils repeating. SERVING SIZE & HOW TO TAKE IT: One softgel twice daily, preferably with meals. Try one before using the full dose. COMPLEMENTARY PRODUCTS: Probiotics, Antioxidants, D-Flame CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Discontinue use if any uncomfortable side effects occur. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:ALLICIN: Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther. 2001 Jul-Aug;18(4):189-93. (AlliSure was used in this study.) Abramovitz D, Gavri S, Harats D, Levkovitz H, Mirelman D, Miron T, Eilat-Adar S, Rabinkov A, Wilchek M, Eldar M, Vered Z. Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet. Coron Artery Dis. 1999 Oct;10(7):515-9. PMID: 10562920 Ankri S, Miron T, Rabinkov A, Wilchek M, Mirelman D. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob Agents Chemother. 1997 Oct;41(10):2286-8. PMID: 9333064 Cellini L, Di Campli E, Masulli M, Di Bartolomeo S, Allocati N. Inhibition of Helicobacter pylori by garlic extract (Allium sativum). FEMS Immunol Med Microbiol. 1996 Apr;13(4):273-7. PMID: 8739190 Chowdhury AK, Ahsan M, Islam SN, Ahmed ZU. Efficacy of aqueous extract of garlic & allicin in experimental shigellosis in rabbits. Indian J Med Res. 1991 Jan;93:33-6. Eilat S, Oestraicher Y, Rabinkov A, Ohad D, Mirelman D, Battler A, Eldar M, Vered Z. Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic. Coron Artery Dis. 1995 Dec;6(12):985-90. PMID: 8723021 Elkayam A, Mirelman D, Peleg E, Wilchek M, Miron T, Rabinkov A, Oron-Herman M, Rosenthal T. The effects of allicin on weight in fructose-induced hyperinsulinemic, hyperlipidemic, hypertensive rats. Am J Hypertens. 2003 Dec;16(12):1053-6. PMID: 14643581 Feldberg RS, Chang SC, Kotik AN, Nadler M, Neuwirth Z, Sundstrom DC, Thompson NH. In vitro mechanism of inhibition of bacterial cell growth by allicin. Antimicrob Agents Chemother. 1988 Dec;32(12):1763-8. Focke M, Feld A, Lichtenthaler K. Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase. FEBS Lett. 1990 Feb 12;261(1):106-8. Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr Cancer. 2000;38(2):245-54. PMID: 11525603 Patya M, Zahalka MA, Vanichkin A, Rabinkov A, Miron T, Mirelman D, Wilchek M, Lander HM, Novogrodsky A. Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21ras. Int Immunol. 2004 Feb;16(2):275-81. PMID: 14734613 Rabinkov A, Miron T, Mirelman D, Wilchek M, Glozman S, Yavin E, Weiner L. S-Allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties. Biochim Biophys Acta. 2000 Dec 11;1499(1-2):144-153. PMID: 11118647 Rabinkov A, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochim Biophys Acta. 1998 Feb 2;1379(2):233-44. PMID: 9528659 Sela U, Ganor S, Hecht I, Brill A, Miron T, Rabinkov A, Wilchek M, Mirelman D, Lider O, Hershkoviz R. Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression. Immunology. 2004 Apr;111(4):391-9. PMID: 15056375 Shadkchan Y, Shemesh E, Mirelman D, Miron T, Rabinkov A, Wilchek M, Osherov N. Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine Model of disseminated aspergillosis. J Antimicrob Chemother. 2004 May;53(5):832-6. Epub 2004 Mar 24. PMID: 15044429 Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC. Antiviral properties of garlic: in vitro effects on influenza B, herpes simplex and coxsackie viruses. Planta Med. 1985 Oct;(5):460-1. PMID: 3001801 Uchida Y, Takahashi T, Sato N. [The characteristics of the antibacterial activity of garlic (author's transl)] Jpn J Antibiot. 1975 Aug;28(4):638-42. PMID: 1099271 Yasuo Yamada and Keizô Azuma. Evaluation of the In Vitro Antifungal Activity of Allicin. Antimicrob Agents Chemother. 1977 April; 11(4): 743–749. ELDERBERRY: Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 423. Gruenwald J, Brendler T, Jaenicke C, et al. (eds). PDR for Herbal Medicines. Montvale, NJ: Medical Economics, 1998, 1116–7. Mascolo N, Autore G, Capasso G, et al. Biological screening of Italian medicinal plants for anti-inflammatory activity. Phytother Res 1987;1:28–31. Murkovic M, Abuja PM, Bergmann AR, et al. Effects of elderberry juice on fasting and postprandial serum lipids and low-density lipoprotein oxidation in healthy volunteers: a randomized, double-blind, placebo-controlled study. Eur J Clin Nutr. Feb2004;58(2):244-9. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press, 1996, 104–5. Yesilada E. Inhibitory Effects of Turkish Folk Remedies on Inflammatory Cytokines: Interleukin-1Alpha, Interleukin-1Beta and Tumor Necrosis Factor Alpha. J Ethnopharmacol. Sept1997;58(1):59-73. Youdim KA, Martin A, Joseph JA. Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radical Biol Med 2000;29:51–60. Zakay-Rones Z, Varsano N, Zlotnik M, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Alt Compl Med 1995;1:361–9. OLIVE LEAF EXTRACT: American Herbal Products Association. Use of Marker Compounds in Manufacturing and Labeling Botanically Derived Dietary Supplements. Silver Spring, MD: American Herbal Products Association; 2001. Bennani-Kabchi N, et al. Effects of Olea europea var. oleaster leaves in hypercholesterolemic insulin-resistant sand rats. Therapie. Nov1999;54(6):717-23. Bisignano G, et al. On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. J Pharm Pharmacol. Aug1999;51(8):971-4. Gonzalez M, et al. Hypoglycemic activity of olive leaf. Planta Medica. 1992;58:513-515. Visoli F, et al. Oleuropein protects low density lipoprotein from oxidation. Life Sciences. 1994;55:1965-71. PDR for Herbal Medicines, 2nd edition. Montvale, NJ: Medical Economics Company; 2000:557. Petroni A, et al. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil.Thromb Res. Apr1995;78(2):151-60. Pieroni A, et al. In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves. Pharmazie. Oct1996;51(10):765-8. Zarzuelo A, et al. Vasodilator effect of olive leaf. Planta Med. Oct1991;57(5):417-9. OREGANO OIL (OIL OF OREGANO, WILD OREGANO, WILD MARJORAM): Dorman HJ, et al. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. Feb2000;88(2):308-16. Force M, et al. Inhibition of enteric parasites by emulsified oil of oregano in vivo. Phytother Res. May2000;14(3):213-4. Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999;86:985–90. Kelm MA, Nair MG, Strasburg GM. Antioxidant and Cyclooxygenase Inhibitory Phenolic Compounds from Ocimum sanctum Linn. Phytomedicine. Mar2000;7(1):7-13. Lamaison JL, et al. Medicinal Lamiaceae with antioxidant properties, a potential source of rosmarinic acid. Pharm Acta Helv. 1991;66(7):185-8. Ponce MM, Navarro AI, Martinez GMN, et al. In vitro effect against Giardia of 14 plant extracts. Rev Invest Clin 1994;46:343–7 [in Spanish]. Stiles JC, Sparks W, Ronzio RA. The inhibition of Candida albicans by oregano. J Applied Nutr 1995;47:96–102. Tantaoui EA, Beraoud L. Inhibition of growth and aflatoxin production in Aspergillus parasiticus by essential oils of selected plant materials. J Environ Pathol Toxicol Oncol 1994;13:67–72. ImmunEnhancer AG (Larch tree Arabinogalactan) Corado J, et al. Impairment of Natural Killer (NK) Cytotoxic Activity in Hepatitis C Virus (HCV) Infection. Exp Immunol. 1997;109:451-457. Currier NL, Lejtenyi D, Miller SC. Effect over time of in-vivo administration of the polysaccharide arabinogalactan on immune and hemopoietic cell lineages in murine spleen and bone marrow. Phytomedicine. 2003 Mar;10(2-3):145-53. PMID: 12725568 Egert D, et al. Studies on Antigen Specificity of Immunoreactive Arabinogalactan Proteins Extracted from Baptisia tinctoria and Echinacea purpurea. Planta Med. 1992;58:163-165. Gonda R, et al. Arabinogalactan Core Structure and Immunological Activities of Ukonan C, An Acidic Polysaccharide from the Rhizome of Curcuma longa. Biol Pharm Bull. 1993;16:235-238. Hagmar B, et al. Arabinogalactan Blockade of Experimental Metastases to Liver by Murine Hepatoma. Invasion Metastasis. 1991;11:348-355. Kelly GS. Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide. Altern Med Rev. 1999 Apr;4(2):96-103. Review. PMID: 10231609 Kim LS, Waters RF, Burkholder PM. Immunological activity of larch arabinogalactan and Echinacea: a preliminary, randomized, double-blind, placebo-controlled trial. Altern Med Rev. 2002 Apr;7(2):138-49. PMID: 11991793 Levine PH, et al. Dysfunction of Natural Killer Activity in a Family With Chronic Fatigue Syndrome. Clin Immunol Immunopathol. 1998;88:96-104. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr. 2001 Aug;20(4):279-85. PMID: 11506055 Rolfe RD. The Role of Probiotic Cultures in the Control of Gastrointestinal Health. J Nutr. Feb2000;130(2S Suppl):396S-402S. Salyers AA, Vercellotti JR, West SE, Wilkins TD. Fermentation of mucin and plant polysaccharides by strains of Bacteroides from the human colon. Appl Environ Microbiol. 1977 Feb;33(2):319-22. PMID: 848954 Uchida A. Therapy of Chronic Fatigue Syndrome. Nippon Rinsho. 1992;50:2679-2683.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=987) Astragalus Fact Sheet
Date:
December 07, 2005 01:15 PM
Astragalus Fact SheetNeil E. Levin, CCN, DANLA 02/10/05LIKELY USERS: Everyone seeking a healthy immune system; Those lacking energy KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg) MAIN PRODUCT FEATURES: A Chinese “tonic herb” used in Traditional Chinese Medicine for night sweats, diarrhea and lack of energy. Tonic herbs are often known as “adaptogens”, helping the body adapt to stresses and modulating immune system responses. Some reports credit Astragalus with shortening colds and strengthening the heart.Astragalus additionally contains triterpene glycosides, also known as astragalosides. ADDITIONAL PRODUCT INFORMATION: Vegetarian formula.May be useful to maintain the patient’s immunity in dialysis patients, those with liver problems and those who have suffered from strokes, according to Chinese studies (not as a treatment for those conditions!). SERVING SIZE & HOW TO TAKE IT: For everyday use take one to five caps per day, either with meals or on an empty stomach. COMPLEMENTARY PRODUCTS: Immune Renew, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and other antioxidants. CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease, though there is some (not enough) evidence that Astragalus may balance immune function for at least one autoimmune disorder. This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
REFERENCES: 1. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=984) Best Bladder Support
Date:
October 28, 2005 05:17 PM
Benefits
Crateva Nurvala Crateva nurvala is an ancient herb used for generations in the traditional Indian sys tem of medicine kn own as Ayurveda. Ancient Ayurvedic practitioners used it as an internal purifier that helped maintain homeostasis and balance. This herb has a long history of use as the herb of choice to maintain healthy urinary tract and bladder function. The tree that is the source of this herb is often found growing along the banks of rivers in the sub-Himalayan regions of India. The stem bark is the part used to benefit urinary health.1 Studies with Crateva nurvala have been conducted in India demonstrating the herb's efficacy in maintaining healthy urinary bladder function. Animal studies with the water extract of Crateva have shown that the herb has the ability to increase the tone of smooth muscle and skeletal muscle. In a rat Model of kidney stones, researchers were able to show that rats given Crateva extract had significantly smaller stones than in the untreated group.3 In addition, a study conducted in dogs showed that the animals receiving Crateva extract for 40 days had significantly higher maintenance of bladder tone than control animals. 2 A tea prepared from the bark of the plant was given to 30 individuals (50 ml twice daily). Baseline measures of urinary function and bladder tone were assessed at the beginning of the study. It was found that when compared to baseline, the Crateva tea showed a high ability to promote healthy urinary function and enhance bladder tone in these individuals after 3 months of use.2 Equisetum Arvense Equisetum arvense, also known as horsetail, is a traditional plant that is especially rich in silica and other essential minerals. It is a member of a prehistoric family of plants that is now one of the most common species in northern temperate climates. In addition to being extremely rich in the mineral silica, horsetail also contains saponins and flavonoids. The combination of these constituents is thought to be responsible for its beneficial properties. 4 Traditional cultures have used horsetail over the years for its various healing properties. Traditional herbalists recommended horsetail for healing wounds be cause of its noticeably astringent effects. Internally,horsetail was used to promote healthy digest ive function.5
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=904) how can I be sure that a lower priced product line can provide high-quality?
Date:
October 20, 2005 10:05 AM
Why should I Buy From Now Foods? “How can I be sure that a lower priced product line can provide high-quality?” Now is a fair priced supplier with a mission to provide quality products that are affordable. Following this guiding principle, the NOW business Model takes less profit out of every bottle we sell. Our competitors will never admit that they’re forced to claim that we don’t match up on quality. But we have nothing to hide, and invite you to check the facts and research our award-winning history. NOW quality meets or exceeds that of our competitors.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=854) Energizing Intimacy - The foundation of a loving relationship is built on communication
Date:
July 27, 2005 04:17 PM
Energizing Intimacy The foundation of a loving relationship is built on communication. Mars/Venus. He said/she said. Action movies/chick flicks. However you choose to characterize differences between the sexes, one this is clear: We tend to see men and women as irreconcilable opposites, people who need each other deeply yet who often don’t know how to live with one another. The stress that ensues when the love connection breaks down aches not only our hearts but the rest of our bodies as well…to say nothing of what it teaches our children about the nature of relationships. This issue of Energy Times is primarily devoted to offering advice and guidance on how to rebuild that love connection; how committed, loving couples can energize intimacy in their relationships. You can find valuable information in stories on the incredible herbs around the world that aid and enhance libido; tips on how women can use natural cosmetics to rev up a partner’s sexual engine; and how couples can create passion in the kitchen, through mutual back massage and after menopause. But those articles offer little help if the foundation of your relationship is not primarily built on communicating your needs and desires- whether inside or outside of the bedroom- and listening, really listening, to the other person in your life. Communication is the holistic way to view sexual health and healing because having a clear understanding with your partner about love and life is the way your relationship can truly be whole. With our national divorce rate hovering around the 50% mark, it is clear that American adults still have an immense learning curve when it comes to talking about sex and intimacy. Sensual images and situations bombard us from books, television, films and Internet sites, yet we seem to be as clueless as ever, not knowing how to talk intelligently about intimate relationships to each other or to our children. Part of the problem stems from the constant barrage of verbal and visual messages- whether from our parents, friends or corporate advertising- that make us incredibly self-conscious about sensuality and our bodies. Many women fight to come to terms with self-images of their bodies as not thin or beautiful enough, while a lot of men struggle to overcome fear and insecurity over their sexual prowess. Carrying such baggage around can’t help but negatively affect the way people relate in a relationship. After all, before you can share love with your partner, you must learn to love yourself. We also have to overcome the energy flows that start getting blocked during childhood, when we learn to restrain our emotional energy for the sake of fitting in. Like water behind a crumbling dam, though, repressed energy leaks out in all sorts of extremely unhealthy ways: Anger, depression, irritability, stress- and sexual dysfunction. Learning to Talk According to Chris Frey, a Missouri-based psychotherapist and pet who has studies sexual relationships, our culture does a great job reaching people about the mechanics and “how-to” of intimacy and the dangers of unprotected sex, but few families or institutions talk about healthy sexuality with a partner. “Culturally, the prevalent myth still is that loves means intuitively knowing what my partner wants,” Frey said in an interview posted on the website of the Missouri Lawyer Assistance Program (MOLAP). “People think if they have to talk, or worse yet, ask about it, then there must be something wrong with them. That’s incorrect. Instead of open communication, people often turn to innuendo, humor and guesswork. When couples break through that, the sensitivity and intimacy built as two uncertain people begin to communicate about sex builds an amazing amount of trust, and most likely, a much more pleasurable relationship.” In fact, trust is a key part of a Model of healthy sexuality developed by social worker, marriage and family therapist and author Wendy Maltz. Called CERTS, Maltz’s Model requires that five basic conditions be met for a healthy sexual relationship: Consent, Equality, Respect, Trust and Safety.
-Steven Hanks and Lisa James
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=713) Best Hyaluronic Acid w/Chondroitin Sulfate - Benefits of...
Date:
July 27, 2005 12:28 PM
Benefits • Supports Healthy Joint Structure and Function* Components of BioCell Collagen II including collagen type II, chondroitin sulfate and hyaluronic acid (HA) can enhance proteoglycans in the joint matrix, thereby providing support for healthy joint function and maintaining joint shock absorption and cushioning. CHONDROITIN SULFATE Chondroitin has been well studied for its effects on joint health. In a 1996 controlled, double-blind trial published in the Journal of Rheumatology, 146 volunteers consumed chondroitin sulfate daily for 6 months. Changes in joint function were measured according to several clinical parameters and carefully analyzed. After the first month, significant improvements were noted and maintained for three months after the subjects stopped taking the chondroitin sulfate.1 In an earlier double-blind study subjects taking chondroitin sulfate had improvements in joint function after three months of use, as determined by both objective and subjective measurements.2 In both studies, the benefits lasted for weeks after subjects stopped taking chondroitin sulfate. In another controlled study, 192 subjects took chondroitin sulfate or a placebo daily for one year. At the end of the trial, chondroitin sulfate maintained healthy joint cartilage thickness, while those on placebo had decreased cartilage. Improvements in joint function also occurred. The researchers reported that chondroitin exerted a clear chondroprotective effect.3 COLLAGEN TYPE II A number of studies have also been conducted on the administration of collagen type II to individuals that have various joint issues. Much of this research has been conducted on animal Models of joint conditions while there are also studies showing the effectiveness of oral collagen type II preparations in humans for maintenance of healthy joints. A randomized controlled trial conducted on 60 patients with joint health issues in 1993 found that oral administration of chicken collagen type II for 3 months led to a significant decrease in swollen and tender joints in this group, as compared to no measurable improvement in the placebo group. There were also no side effects seen with the treatment.4 A second multicenter, double-blind, placebo-controlled trial in 274 individuals with joint issues was published in 1998. The participants were given collagen type II orally for 24 weeks. Positive effects of the treatment were noted while no adverse effects were seen.5 A paper published in 2000 reviewed the literature to assess the role of hydrolyzed collagen in joint and bone health. It was found that hydrolyzed collagen when administered orally was able to support joint health in most of the trials reviewed while the author concluded that, “Its high level of safety makes it attractive as an agent for long-term use.”6 HYALURONIC ACID (HA) Most of the literature on hyaluronic acid and joint health deals with its intra-articular use, or injections of HA directly into the joints. In this realm, there is good evidence for the effects of HA on joint function. A study was conducted with injectable HA in individuals with TMJ (temporomandibular joint) conditions. Participants received two injections, each one week apart, or placebo injections with saline. In the HA group, the researchers found decreased clicking sounds and increased function of the joint at 1 month (90% of patients showed improvement) and 6 months (63%) of follow-up, compared to about 26% of the placebo group showing improvement at 6 months.7
A pair of researchers also conducted a literature review of the trials using HA for improving joint health that was published in 2005. Their findings indicate a positive role for HA in modifying the structure of the joint and slowing progressive deterioration of joint function and mobility.8 Hyaluronic acid seems to have a natural affinity for joint tissue, and is therefore able to help support healthy joint structure and function.
• SuSupports Healthy Joint Structure and Function* Hyaluronic Acid and Collagen are both vital components of skin tissue. Both compounds are known to decline with aging. Collagen is a vital structural component of the skin. It is also one of the most important substances required for proper skin barrier function and health. Collagen, as a major component of the connective tissue, provides structural support, increasing elasticity and tone of the skin. In 1994, researchers performed comparative measurements of hyaluronic acid levels in the skin of young and elderly individuals. The researchers had hypothesized that a major reason for the aged appearance of skin in the elderly is a reduction of hyaluronic acid levels. What they found using their methods is that there is a progressive reduction in the number of hyaluronic acid granules in human skin with age, until a complete absence of these granules was seen in individuals 60 years or older. These variations in HA levels with age could, according to the researchers, account for the decreased turgidity, wrinkled appearance and altered elasticity of skin tissue.9 Further research was needed to determine the effect of exogenously administered HA on the suppleness of human skin. In a laboratory study conducted in 1998, researchers analyzed the effects of HA given to live human skin cells. Whereas the cells on their own had a low rate of renewal, hyaluronic acid added to the cells resulted in increased proliferation of skin cells in the collagen matrix. This showed that supplementing skin cells with HA caused a significant increase in the ability of cells to go through the cell cycle.10 One of the major benefits of this may be hyaluronic acid’s ability to continually renew skin tissue to help maintain a youthful appearance of the skin. Safety Suggested Adult Use: Take 2 capsules daily, or as directed by a health care practitioner. Take with 8-10 ounces of water, with or without food. Scientific References 1. Morreale P, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol (1996) 23:1385-91. 2. Mazières B, et al. Chondroitin sulfate for the treatment of coxarthrosis and gonarthrosis. A prospective, multicenter, placebo-controlled, double blind trial with five months follow up. Rev. Rhum. Mal. Ostèoartic. 1992;59(7-8):466-472. 3. Pipitone V, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate versus placebo in patients with femorotibial gonarthritis. Current Therapeutic Research 1992 52(4):608-38. 4. Trentham DE, et al. Effects of oral administration of type II collagen on rheumatoid arthritis. Science. 1993 Sep 24; 261(5129) 1727-30. 5. Barnett ML, et al. Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 1998 Feb; 41(2): 290-7. 6. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000 Oct;30(2):87-99. 7. Hepguler S, et al. The efficacy of intra-articular sodium hyaluronate in patients with reducing displaced disc of the temporomandibular joint. J Oral Rehab. 2002; 29: 80-86. 8. Goldberg VM, Buckwalter JA. Hyaluronans in the treatment of osteoarthritis of the knee: evidence for disease-modifying activity. Osteoarthritis Cartilage. 2005 Mar;13(3):216-24. 9. Ghersetich I, et al. Hyaluronic acid in cutaneous intrinsic aging. Int J Dermatol. 1994 Feb; 33(2): 119-22. 10. Greco RM, et al. Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix. J Cell Physiol. 1998 Dec; 177(3): 465-73.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=698) Strontium Bone Maker 60 VC - Strengthen Bones
Date:
July 27, 2005 12:06 PM
Benefits Helps maintain strong, healthy bones.* In Vitro and Animal Studies Strontium is a bone-seeking mineral incorporated by ionic substitution for calcium onto the crystal surface of bone.2 In the test-tube (in vitro), strontium inhibits the activity of osteoclasts, bone cells that break down bone, or “resorb” bone as part of the normal bone reModeling process.3 The effect of strontium, in the form of strontium ranelate (a salt of strontium and ranelic acid), was studied in monkeys over a six-month period. Strontium altered the reModeling of bone in the monkeys, resulting in decreased bone resorption with a concomitant maintenance of bone formation. A trend toward increased volume of osteoid, the organic matrix of bone, was observed, although this was not associated with defects in bone mineralization.4 In another animal study, monkeys fed strontium at high doses for six weeks showed a marked increase in bone strontium content. No harmful effects on bone mineral chemistry or structure occurred.5 At low doses, strontium has been shown to increase the number of bone forming sites in thighbones of adult rats, without adverse effects on the mineral content of bone or mineralization of the organic bone matrix.6 Strontium was shown to reverse bone loss induced by estrogen deficiency in rats.7 Clinical Trials Human clinical trials have examined the effect of strontium on bone in postmenopausal women. In the dose-ranging (Phase 2) PREVOS trial, women in early menopause were administered strontium ranelate or a placebo for two years. Strontium ranelate was given at daily doses of 125 mg, 500 mg or 1 gram. (Total weight of compound; strontium plus ranelic acid). Compared to women in the placebo group, who lost bone, women on strontium at the 1 gram dose showed statistically significant increases in bone mineral density (BMD) of the hip, thigh and lumbar spine. Biochemical markers of bone formation, such as serum alkaline phosphatase, increased. No effect on markers of bone resorption was observed, leading to the conclusion that strontium ranelate, at the 1 gram daily dose, increased bone formation without decreasing bone resorption proportionally. It was concluded that 1 gram per day is the minimum effective daily dose of strontium ranelate in these women.8 In another Phase 2 trial (STRATOS trial), 353 postmenopausal women with osteoporosis, who had experienced at least one spinal fracture, took strontium ranelate for two years at daily doses of 500 mg, 1 gram or 2 grams. Women on the 2-gram dose showed a significantly greater increase in lumbar spine BMD than those on placebo. The number of subjects who had new spinal deformities was significantly reduced.9 As in the PREVOS trial, serum levels of alkaline phosphatase, a marker of bone formation, increased, while markers of bone resorption (breakdown) decreased. The overall conclusion is that the minimum effective daily dose of strontium ranelate (whole compound) is 1 gram in early postmenopausal non-osteoporotic women and 2 grams in postmenopausal women with osteoporosis.10 Phase 3 efficacy studies on strontium ranelate have been conducted on 1649 subjects in 12 countries. These studies began with an open-run (non-controlled study period in which subjects took calcium and vitamin D supplements to normalize their blood levels of these nutrients.11 Following this, two parallel groups were administered 2 grams daily of strontium ranelate or placebo for 3-years. The subjects continued to take calcium and vitamin D during the study. In subjects on strontium ranelate, BMD increased in the lumbar vertebrae by 14.4 percent and in the thighbone by 8.3 percent. The number and risk of vertebral fractures decreased.12 Safety Suggested Use: Take two capsules daily. Calcium intake must also be adequate. Do not take this product with calcium supplements. Strontium ranelate was well-tolerated in the trials discussed above. The incidence of adverse events in subjects on strontium ranelate was statistically equivalent to the placebo groups, and no negative effects on hematology and other biochemical parameters have been observed. In view of the fact that subjects on the strontium trials also took calcium, and in some cases vitamin D, to maintain normal blood levels of these nutrients, it is important to ensure calcium and vitamin D intakes are adequate when supplementing with strontium. This is underscored by earlier research on animals suggesting that increasing the intake of strontium via diet may demineralize bone when calcium is deficient.13 In rats with chronic kidney failure, strontium has been shown to cause osteomalacia, a condition in which bone is softened due to lack of mineral content. For this reason, people on kidney dialysis should not use strontium supplements.14 Scientific References 1. Shorr E, Carter AC. The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man. Bull Hosp Joint Dis 1952; 13:59 -66. 2. Dahl SG, Allain P, Marie PJ, et al. Incorporation and distribution of strontium in bone. Bone 2001;28(4):446-53. 3. Baron R, Tsouderos Y. In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol 2002; 450:11-17. 4. Buehler J, Chappuis P, Saffar JL, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis) Bone 2001;29(2):176-79. 5. Boivin G, Deloffre P, Perrat B, et al. Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. J Bone Miner Res. 1996 Sep;11(9):1302-11. 6. Grynpas MD, Hamilton E, Cheung R, et al. Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone 1996;18(3):253-9. 7. Marie PJ, Hott M, Modrowski D, et al. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats. J Bone Miner Res 1993;8(5):607-15. 8. Reginster JY, Deroisy R, Dougados M, et al. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose ranging, placebo-controlled PREVOS trial. Osteoporosis Int 2002; 13:925-31. 9. Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis––a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 2002;87(5):2060-66. 10. Reginster JY, Meunier PJ. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. Osteoporosis Int 2003; 14(Suppl 3):S56-S65. 11. Meunier PJ, Reginster JY. Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis. Osteoporosis Int 2003;14(Suppl 3):S66-76. 12. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004;350(5):459-68. 13. Grynpas MD, Marie PJ. Effects of strontium on bone quality and quantity in rats. Bone 1990;11:313-19. 14. Schrooten, I, Cabrera W, Goodman WG, et al. Strontium causes osteomalacia in chronic renal failure in rats. Kidney Int 1998;54:448-56.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=697) Best Lutein Featuring Biolut Marigold Ext., 60 VC
Date:
July 27, 2005 11:54 AM
Benefits It has been well established that lutein is present in high concentrations in the retinal tissue of the human eye. However, a study was conducted in human volunteers to determine whether taking lutein in supplement form actually increased the density of the carotenoid pigments present in the macula. In this study of eight individuals, researchers estimated the density of the macular pigments prior to having each individual take 10 mg of lutein daily in supplement form for 12 weeks. Plasma lutein concentrations were measured at 4-week intervals. During the course of the study, plasma levels increased five-fold from pre-supplement measures. It was also shown that macular pigment density increased by an average of 5.3% after 4 weeks due to increased deposition of lutein in optical tissues.1 A second study compared the oral bioavailability of esterified lutein, the form in Best Lutein, versus non-esterified lutein in 18 human volunteers. Serum levels of lutein were measured at particular timepoints after consumption of a single dose of lutein. Researchers found that in these individuals, the lutein ester formulation was nearly 62% more bioavailable than non-esterified lutein, as determined by a higher mean area under the curve (AUC) and higher serum concentrations.2 A study was also conducted to investigate the possible role of specific nutrients in protecting the lens of the eye against aging, a risk factor for compromised visual function. The study was comprised of 376 individuals aged from 18 to 75. Of the nutrients measured, it was found that the lenses of individuals with higher concentrations of lutein and zeaxanthin showed less of an effect from the aging process. The investigators concluded that these carotenoids may play a protective role in supporting the maintenance of healthy vision.3 In addition, a double-blind placebo controlled trial was performed in ninety individuals who had signs of compromised visual function. Individuals were divided into three groups and received either 10 mg lutein, 10 mg lutein plus a multivitamin/multimineral formulation, or placebo for 12 months. In both the lutein and lutein plus other nutrients groups, improvements were seen in mean eye macular pigment optical density, visual acuity and contrast sensitivity. No improvements were noted in the placebo group.4 These results demonstrate lutein’s beneficial effect on maintaining healthy visual function. • Potent Antioxidant Protection* Most of the beneficial effects of lutein are ascribed to its potent free radical scavenging abilities. It is well-known that lutein is a carotenoid related to beta-carotene and possesses antioxidant activity against a number of reactive oxygen species.5 More direct evidence for the free radical scavenging activity of lutein is found in studies of its effects on human lens epithelial cells. Cell cultures were exposed to ultraviolet light after pretreatment with lutein or alpha-tocopherol. Both nutrients were found to reduce ultraviolet-induced damage to lens epithelial cells. However, lutein was shown to have significantly higher photoprotective activity than alpha-tocopherol6, demonstrating its potential as a high-powered antioxidant. A further review of the mechanisms of lutein in conferring a protective role reveals evidence for its antioxidant activity in various body tissues. Lutein has been shown to be an effective antioxidant in vitro as well as in experimental Models of a number of body systems.7 • Diverse clinical benefits* Evidence from various experimental trials suggests that lutein may play a protective role on the circulatory and cardiovascular systems. Its antioxidant activity may also extend to the heart, skin, lungs and blood vessels, making it a nutrient with diverse clinical benefits. Lutein possesses the ability to promote the health of many body tissues.8 Safety Suggested Adult Use: One capsule daily, or as directed by a health care professional. Take with or without food.
Scientific References 2. Bowen PE, et al. Esterification does not impair lutein bioavailability in humans. J Nutr. 2002 December; 132: 3668-3673. 3. Berendschot TT, et al. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Arch Opthalmol. 2002 Dec; 120(12): 1732-7. 4. Richer S, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr; 75(4): 216-230. 5. "Lutein and Zeaxanthin". PDR Health. 6. Chitchumroonchokchai C, et al. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. J Nutr. 2004 Dec; 134(12): 3225-32. 7. Krinsky NI. Possible biologic mechanisms for a protective role of xanthophylls. J Nutr. 2002; 132: 540S-542S. 8. Mares-Perlman JA, et al. The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview. J Nutr. 2002; 132: 518S-524S.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=696) Best Mangosteen 10% Extract with xanthone flavonoids
Date:
July 27, 2005 11:31 AM
Benefits • Defends Against Free Radicals* The xanthone flavonoids and other compounds in mangosteen fruit are responsible for its high level of antioxidant activity. In vitro tests have been conducted on XanoMax? mangosteen 10% extract to determine the level of free radical scavenging ability in both watery and fatty environments. A major test recognized as the industry standard for measuring antioxidant activity is known as the ORAC (Oxygen Radical Absorbance Capacity) assay. The ORAC test is an in vitro assay that works by measuring the amount of free radical damage done to a fluorescent probe (measured by a change in probe intensity). Antioxidants lessen the damage to the probe fluorescence, which indicates a reduction in free radical damage. This measure is used to quantify the antioxidant’s (or combination of antioxidants) capacity to quench free radicals. This quantification is known as the total ORAC value. The total ORAC value provides a relative measure of total antioxidant strength of any substance, allowing for comparison of different mixtures. A high ORAC value corresponds to a high total in vitro antioxidant capacity. The development of the ORAC test has led to a number of commonly eaten foods being assessed in terms of total ORAC scores per serving. Similarly, particular combinations of antioxidants, such as those in nutritional formulas, can also be assessed for their total ORAC scores. This has led to the ability to determine the potential usefulness of a particular supplement in increasing overall antioxidant capacity. When XanoMax? mangosteen 10% extract was tested for ORAC value, the resulting antioxidant potential was over 3,500 ORAC units per gram of extract. This result is extremely high. ORAC values of compounds vary with their nutrient concentration, moisture content and other factors. For comparison purposes, whole blueberries, considered to be a rich source of antioxidants, had an ORAC value of 61 units per gram, while pomegranate tested at 105 ORAC units per gram.1 XanoMax? mangosteen extract is a potentially rich source of beneficial antioxidants* • Maintains Healthy Immune Function* Evidence from several animal and in vitro studies on various cell lines suggests that components of mangosteen fruit extract may play a role in modulating several factors important to healthy immune function. Of the active components, xanthone derivatives seem to play the major role in influencing parameters of immune function in animals and in vitro Models. Mangostin is the xanthone derivative that most of these studies have focused on. A study published in 2002 assessed the effects of mangosteen extracts on the release of histamine from rat cell lines. The comparison was made to extracts of a plant frequently used in Japan, Rubus suavissimus, which is a known inhibitor of IgE-mediated histamine release from these cells. The assay showed that the mangosteen extracts used inhibited the release of histamine from these cells more potently than the extract of Rubus suavissimus. In addition, the authors compared the two herbs for prostaglandin E2 synthesis in another rat cell line and found that the mangosteen extract potently inhibited prostaglandin E2 synthesis in this in vitro trial, whereas the other herb had no effect.2 An earlier study was performed in guinea pig tracheal and rabbit thoracic aortal tissue. In this study, alpha mangostin prevented histamine-induced contraction and was shown to be a competitive histamine receptor antagonist in the smooth muscle tissue of the trachea and aorta of the animals selected. The results seen in this laboratory study were determined to be concentration-dependent. The authors suggested that alpha mangostin should undergo further studies to determine its effects on the modulation of the histamine response.3 Further in vitro assessments point to potential actions of mangosteen components in modulating effectors of occasional inflammation in the immune system. Studies in rat glioma cells suggest that mangostins inhibit enzymatic reactions that can lead to the production of specific prostaglandins.4,5 By inhibiting these reactions, mangostins may play a role in modulating overall immune function, promoting healthy immunity.
Mangosteen and its constituents hold much promise for their potential ability to enhance immune function and promote health. In addition to being a highly nutritious food, mangosteen extract is full of antioxidant activity. It has an extremely high ORAC value and a great potential for enhancing free radical defenses in the body. Best Mangosteen 10% extract contains XanoMax ™, which is standardized to a high level of active mangostin, the class of compounds shown in in vitro studies to benefit certain aspects of immune function. Safety Scientific References
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=694) Maintaining Healthy Veins
Date:
July 25, 2005 09:36 PM
More than 40 million Americans have varicose veins, a term in Latin meaning “twisted and wollen blood vessel.” Although the condition is rarely disabling, it is disfiguring, causing discomfort and embarrassment to those afflicted. many cases, genetic predisposition and gender determine who will develop varicose veins. A full 75% of Americans with the condition ar e women. At risk some women who may experience the beginning of this condition during pregnancy as the enlarging womb presses on the veins in the abdomen, increasing the pressure in the veins of the legs. Age is another factor as the skin becomes less elastic, lessening vein support. Some individuals are genetically edisposed to a malfunction of the one-way valves that may cause a back low of blood to pool in super ficial veins, stretching and swelling them. some health care professionals believe that our Western diet, high in refined carbohydrates and fat and low in fiber, may cause straining during bowel movement leading to hemorrhoids (anal varicose veins) and increase pressure on the leg veins. Our Western diet also eads to obesity and cardiovascular conditions such as plaque deposits in the arteries, abnormal clotting and platelet aggregation, cardiac dysfunction or failure, all leading to a weakened venous system that could increase the chance of developing varicose veins and edema (swelling in the legs). Those who ar e predisposed to varicose veins and who stand for long periods of time, especially on hard floors, may develop them more quickly. If you are at risk of developing this condition as you age, emphasizing a diet high in fiber, legumes and grains, fresh fruits and vegetables will improve your chances of maintaining good vein health. Other nutritional supplements that may be beneficial are horse chestnut seeds, Centella Asiatica, Milk Thistle, Butcher’s Broom and bioflavonoids. Horse chestnut seeds have a long historical use in the treatment of varicose veins and hemorrhoids. One active ingredient that has been researched is a saponin mixture called Aescin. In a recent study, Aescin was as effective as compression stockings in reducing leg swelling in patients with chronic venous insufficiency. Centella Asiatica is a common edible herb also known as Gotu Kola in India. When grown in Madagascar, it has a higher content of a compound called triterpenic fraction (TTFCA) than the same herb has when grown in other parts of the world. This compound has been used for many years in the treatment of venous hypertension. In a study conducted in 1989, 120mg dosage was safely used in patients with poor venous blood flow and it improved the condition after one or two months. Often, inflammation is a component of varicose veins. Milk Thistle, another herb commonly used for the treatment of liver disorders, was also found to reduce inflammation and edema in a recent Spanish study. A bushy ever green perennial found throughout much of the Western world is Butcher’s Broom. Its saponin glycosides ar e anti-inflammatory and helped contract blood vessels, especially veins thus making it an important component of any natural for mulation used to improve venous conditions. Certain bioflavonoids, such as quer cetin and rutin, have also been shown to be useful in the natural tr eatment of varicose veins as a strengthener of capillary and vein walls. There are other nutritional supplements including vitamins and minerals that may help maintain vein health as we age. They are listed in my new book “A Doctor’s Guide to Natural Medicine.” To improve vein health and to decrease your chance of developing varicose veins: do not stand for long periods of time especially on hard sur faces such as concrete. If you can’t avoid this, make sure your shoes are well cushioned. If you are sitting for long periods of time either working or traveling, take walking breaks. Stop crossing your legs and exercise regularly to incorporates rhythmical contraction of the leg muscles. Rest with your legs elevated when taking a break. W earing good support hose and avoiding tight knee-highs will promote good blood flow. These things can be very important if you ar e genetically pr edisposed to varicose veins. Starting nutrients early may help diminish or delay venous problems. Micromedex, Inc. Volume 96, 1974-1998. Diehmetal. Microcirculation Laboratory, Cardiovascular Clinic, Chieti, Italy. Efficacy of Centellase in the Treatment of Venous Hypertension Evaluated by a Combined Micro circulatory Model. G. Belcaroetal. Current Therapeutic Research, Vol. 46, No. 6, Dec. 1989. Effect of Silymarin on Different Acute Inflammation Models and on Leukocyte Migration. R. de la Puertaetal, J. Pharm. Parmacol. 1996, 48: 968-970 Merck Sciential Review, no. 10, 1995-04-30, pp. 2
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=650) Pain - Post Op and Relaxation
Date:
July 13, 2005 09:24 AM
Relaxation, Music Reduce Post-Op Pain. New research has found that relaxation and music, separately or together, significantly reduce patients' pain following major abdominal surgery. The study, published in the May issue of the journal Pain, found that these methods reduce pain more than pain medication alone. Led by Marion Good, PhD, RN, of Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, the study is supported by the National Institute of Nursing Research (NINR), at the National Institutes of Health. "This is important news for the millions of Americans who undergo surgery and experience postoperative pain each year," said Dr. Patricia A. Grady, director of the NINR. "Better pain management can reduce hospital stays and speed recovery, ultimately improving patients' quality of life." Dr. Good and her research team studied three groups of patients undergoing abdominal surgery. In addition to the usual pain medication, one group used a jaw relaxation technique, another group listened to music, and a third group received a combination of relaxation and music. Findings revealed that, after surgery, the three treatment groups had significantly less pain than the control group, which received only pain medication. "Both medication and self-care methods which involve patient participation are needed for relief," said Dr. Good. "These relaxation and music self-care methods provide more complete relief without the undesired side effects of some pain medications." The findings have important implications for the 23 million people who undergo surgery and experience postoperative pain annually in the United States. Pain can hamper recovery by heightening the body's response to the stress of surgery and increasing tissue breakdown, coagulation and fluid retention. Pain also interferes with appetite and sleep and can lead to complications that prolong hospitalization. Dr. Good and her research staff worked with 500 patients aged 18-70, who were undergoing gynecological, gastrointestinal, exploratory or urinary surgery. Prior to surgery, those in the music, relaxation or combination groups practiced the techniques. The relaxation technique consisted of letting the lower jaw drop slightly, softening the lips, resting the tongue in the bottom of the mouth, and breathing slowly and rhythmically with a three-rhythm pattern of inhale, exhale and rest. Patients in the music group chose one of five kinds of soothing music--harp, piano, synthesizer, orchestral or slow jazz. On the first and second days after surgery, all patients received morphine or Demerol for pain relief by pressing a button connected to their intravenous patient controlled analgesia pumps. The groups receiving the additional intervention used earphones to listen to music and relaxation tapes during walking and rest, while the control group did not. The research team measured the patients' pain before and after 15 minutes of bed rest and four times during walking to see if the sensation and distress of pain changed. Dr. Good found that during these two days postsurgery the three treatment groups had significantly less pain than the control group during both walking and rest. "Patients can take more control of their postoperative pain using these self-care methods," says Dr. Good. "Nurses and physicians preparing patients for surgery and caring for them afterwards should encourage patients to use relaxation and music to enhance the effectiveness of pain medication and hasten recovery." Dr. Good's findings have implications for future research into the effectiveness of self-care methods on other types of pain, including chronic pain, cancer pain, and pain of the critically ill. ----------------------------- Vitamin D Lack Linked to Hip Fracture. Vitamin D deficiency in post-menopausal women is associated with increased risk of hip fracture, according to investigators at Brigham and Women's Hospital in Boston, Mass. In a group of women with osteoporosis hospitalized for hip fracture, 50 percent were found to have a previously undetected vitamin D deficiency. In the control group, women who had not suffered a hip fracture but who were hospitalized for an elective hip replacement, only a very small percentage had vitamin D deficiency, although one-fourth of those women also had osteoporosis. These findings were reported in the April 28, 1999, issue of the Journal of the American Medical Association. The study, conducted by Meryl S. LeBoff, MD; Lynn Kohlmeier, MD; Shelley Hurwitz, PhD; Jennifer Franklin, BA; John Wright, MD; and Julie Glowacki, PhD; of the Endocrine Hypertension Division, Department of Internal Medicine, and Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, was supported by grants from the National Institute on Aging (NIA) and the National Center for Research Resources (NCRR. These investigators studied women admitted to either Brigham and Women's Hospital or the New England Baptist Hospital, both in Boston, between January 1995 and June 1998. A group of 98 postmenopausal women who normally reside in their own homes were chosen for the study. Women with bone deterioration from other causes were excluded from the study. There were 30 women with hip fractures caused by osteoporosis and 68 hospitalized for elective joint replacement. Of these 68, 17 women also had osteoporosis as determined by the World Health Organization bone density criteria. All the participants answered questions regarding their lifestyle, reproductive history, calcium in their diet, and physical activity. Bone mineral density of the spine, hip, and total body were measured by dual X-ray absorptiometry (DXA) technique, as was body composition. Blood chemistry and urinary calcium levels were analyzed. The two groups of women with osteoporosis did not differ significantly in either time since menopause or bone density in the spine or hip. They did, however, differ in total bone density. The women admitted for a hip fracture had fewer hours of exercise than the control group. Fifty percent of the women with hip fractures were deficient in vitamin D, 36.7 percent had elevated parathyroid hormone (PTH) levels (a hormone which can stimulate loss of calcium from bone), and 81.8 percent had calcium in their urine, suggesting inappropriate calcium loss. Blood levels of calcium were lower in the women with hip fractures than in either elective group. These researchers propose that vitamin D supplementation at the time of fracture may speed up recovery and reduce risk of fracture in the future. Current Dietary Reference Intake Guidelines contain a daily recommendation of 400 IU of vitamin D for people aged 51 through 70 and 600 IU for those over age 70. "We know that a calcium-rich diet and regular weight-bearing exercise can help prevent osteoporosis. This new research suggests that an adequate intake of vitamin D, which the body uses to help absorb calcium, may help women to reduce their risk of hip fracture, even when osteoporosis is present," observed Dr. Evan C. Hadley, NIA Associate Director for geriatrics research. "Osteoporosis leads to more than 300,000 hip fractures each year, causing pain, frequent disability, and costly hospitalizations or long-term care. "Prevention of such fractures would greatly improve the quality of life for many older women and men, as well as significantly reduce medical costs." The bones in the body often undergo rebuilding. Some cells, osteoclasts, dissolve older parts of the bones. Then, bone-building cells known as osteoblasts create new bone using calcium and phosphorus. As people age, if osteoporosis develops, more bone is dissolved than is rebuilt, and the bones weaken and become prone to fracture. Also in many older persons, levels of vitamin D in the blood are low because they eat less or spend less time in the sun, which stimulates the body's own production of vitamin D. Experts do not understand fully the causes of osteoporosis. However, they do know that lack of estrogen which accompanies menopause, diets low in calcium, and lack of exercise contribute to the problem. Eighty percent of older Americans who face the possibility of pain and debilitation from an osteoporosis-related fracture are women. One out of every two women and one in eight men over the age of 50 will have such a fracture sometime in the future. These fractures usually occur in the hip, wrist, and spine. ----------------------------- Sleep Apnea, Diabetes Link Found. Adults who suffer from obstructive sleep apnea are three times more likely to also have diabetes and more likely to suffer a stroke in the future, according to a new UCLA School of Dentistry/Department of Veterans Affairs study published today in the Journal of Oral and Maxillofacial Surgery. Sleep apnea, a serious condition marked by loud snoring, irregular breathing and interrupted oxygen intake, affects an estimated nine million Americans. The culprit? Carrying too many extra pounds. "The blame falls squarely on excess weight gain," said Dr. Arthur H. Friedlander, associate professor of oral and maxillofacial surgery at the UCLA School of Dentistry and associate chief of staff at the Veterans Affairs Medical Center in Los Angeles. Surplus weight interferes with insulin's ability to propel sugars from digested food across the cell membrane, robbing the cells of needed carbohydrates. Diabetes results when glucose builds up in the bloodstream and can't be utilized by the body. Being overweight can also lead to obstructive sleep apnea, according to Friedlander. "When people gain too much weight, fatty deposits build up along the throat and line the breathing passages," he explained. "The muscles in this region slacken during sleep, forcing the airway to narrow and often close altogether." Reclining on one's back magnifies the situation. "When an overweight person lies down and goes to sleep," Friedlander said, "gravity shoves the fat in the neck backwards. This blocks the airway and can bring breathing to a halt." Friedlander tested the blood sugar of 54 randomly selected male veterans whom doctors had previously diagnosed with obstructive sleep apnea. He discovered that 17 of the 54 patients, or 31 percent, unknowingly suffered from adult-onset diabetes. Using the same sample, Friedlander also took panoramic X-rays of the men's necks and jaws. The X-rays indicated that 12 of the 54 patients, or 22 percent, revealed calcified plaques in the carotid artery leading to the brain. These plaques block blood flow, significantly increasing patients' risk for stroke. Seven of the 12, or 58 percent, were also diagnosed with diabetes. In dramatic comparison, the 17 patients diagnosed with diabetes showed nearly twice the incidence of blockage. Seven of the 17 men, or 41 percent, had carotid plaques. Only five of the 54 patients who displayed plaques did not have also diabetes. If he conducted this study today, Friedlander notes, he would likely find a higher number of diabetic patients. After he completed the study in 1997, the American Diabetes Association lowered its definition for diabetes from 140 to 126 milligrams of sugar per deciliter of blood. "This is the first time that science has uncovered a link between sleep apnea and diabetes," said Friedlander. "The data suggest that someone afflicted with both diabetes and sleep apnea is more likely to suffer a stroke in the future." "Persons going to the doctor for a sleep-apnea exam should request that their blood be screened for diabetes, especially if they are overweight," he cautioned. More than half of the individuals who develop diabetes as adults will need to modify their diet and take daily insulin in order to control the disease, he added. ------------------------------ Stress, Surgery May Increase CA Tumors. Stress and surgery may increase the growth of cancerous tumors by suppressing natural killer cell activity, says a Johns Hopkins researcher. Malignancies and viral infections are in part controlled by the immune system's natural killer (NK) cells, a sub-population of white blood cells that seek out and kill certain tumor and virally infected cells. In a study using animal Models, natural killer cell activity was suppressed by physical stress or surgery, resulting in a significant increase in tumor development. These findings suggest that protective measures should be considered to prevent metastasis for patients undergoing surgery to remove a cancerous tumor, according to Gayle Page, D.N.Sc., R.N., associate professor and Independence Foundation chair at the Johns Hopkins School of Nursing. "Human studies have already found a connection between the level of NK activity and susceptibility to several different types of cancer," says Page, an author of the study. "We sought to determine the importance of stress-induced suppression of NK activity and thus learn the effects of stress and surgery on tumor development. "Many patients undergo surgery to remove cancerous tumors that have the potential to spread. If our findings in rats can be generalized to such clinical settings, then these circumstances could increase tumor growth during or shortly after surgery." The research was conducted at Ohio State University College of Nursing and the Department of Psychology at UCLA, where Page held previous positions, and at Tel Aviv University. Results of the study are published in the March issue of the International Journal of Cancer. In laboratory studies, Page and her colleagues subjected rats to either abdominal surgery or physical stress, and then inoculated them with cancer cells. In the rats that had undergone surgery, the researchers observed a 200 to 500 percent increase in the incidence of lung tumor cells, an early indicator of metastasis, compared with rats that had not received surgery. The experiment also showed that stress increased lung tumor incidence and significantly increased the mortality in the animals inoculated with cancer cells. "Our results show that, under specific circumstances, resistance to tumor development is compromised by physical stress and surgical intervention," says Page. "Because surgical procedures are life-saving and cannot be withheld, protective measures should be considered that will prevent suppression of the natural killer cell activity and additional tumor development. "Researchers do not yet know how to prevent surgery-induced immune suppression, but early animal studies have shown increased use of analgesia reduces the risk." The study was funded by the National Institutes of Health, and the Chief Scientist of the Israeli Ministry of Health. Lead author was Shamgar Ben-Eliyahu, Ph.D., and other authors were Raz Yirmiya, Ph.D., and Guy Shakhar.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=599) MECHANISMS OF CHITOSAN FAT- BINDING
Date:
June 25, 2005 08:02 PM
MECHANISMS OF CHITOSAN FAT- BINDING The exact way(s) that Chitosan prevents fat absorbtion is not fully understood but a number of experimental observations support two basic mechanisms. The first mechanism involves the attraction of opposite charges which can be compared to the attraction of opposite magnetic poles. The second entrapment mechanism can be compared to the effect of a net. In the first mechanism the positive charges on chitosan attract the negatively charged fatty acids and bile acids binding them to the indigestible chitosan fiber. This mechanism can explain why chitosan reduces LDL cholesterol levels. Our bodies make bile acids in the liver using the cholesterol from LDL. When chitosan binds bile acids it increases the rate of LDL loss thus improving the LDL to HDL ratio. If enough bile acids are bound, the fats are not solublized, which prevents their digestion and absorption. The second mechanism (figure 2) describes a netting effect of chitosan fiber. In this Model the Chitosan wraps around fat droplets and prevents their being attacked and digested by lipid enzymes. Fats unprotected by Chitosan are digested and absorbed. The “netting” mechanism has been seen to operate in vivo. 108 Substances that Enhance the Action of Chitosan Fibers can be likened to a tangled-up chain. Fibers must “unravel” in order for them to be of maximum benefit to us. “Unraveling” is especially critical for chitosan because each link has a hook on which to attach lipids. Chitosan can absorb an average of 4 to 5 times its weight in lipids. Reports of numbers above and below this range have also been reported and may well reflect the rate or extent of unraveling that had taken place. Fiber formulations can be prepared that unravel rapidly and swell quickly. These highly effective formulations are called superabsorbants. When certain substances are added to chitosan, its remarkable fat-binding ability can be significantly enhanced. Ascorbic Acid D-Ascorbic acid (erythorbic acid) and L-ascorbic acid are C-vitamins which enhance chitosan’s ability to bind lipids. Combining chitosan with ascorbic acid results in even less fat absorption and greater fecal fat losses.77,108 In one study the addition of ascorbic acid to a chitosan enriched diet increased fecal fat losses by 87 percent and decreased fat absorption by over 50 percent.77 Cholesterol oxides cause lesions in artery walls which predispose blood vessels to collect plaque. These dietary cholesterol oxides profoundly influence the initiation of heart disease.Free radicals can also contribute to the formation of cholesterol oxides which are even more likely to damage the heart. Cholesterol oxides have been found in deep-fried foods, powdered eggs, processed meats and in human blood itself. Consequently, taking antioxidants like ascorbic acid is vital to protect against the cellular damage this type of free radical causes.112 Citric Acid In feeding experiments with animals, adding citric acid to a chitosan enriched diet resulted in a decreased feed consumption.77 The most likely explanation for this effect is that the citric acid may be enhancing the swelling action of chitosan leading to a sense of fullness, producing satiety and appetite suppression. Indoles Indoles are remarkable phytochemicals which have the ability to selectively activate certain Mixed Function Oxidases (MFOs).113 These MFO’s help balance estrogen metabolism and prepare dietary toxins for elimination before they are absorbed. The presence of fiber in the intestines provides a bulk agent to carry the metabolized toxins out of the body. Chelat ed Minerals The very best approach to weight loss is to nutritionally augment food choices with nutrient supplementation. Certain biochemical compounds are essential to promoting vigor during the process of thermogenesis. Chelated minerals act to bolster, support and protect the organ systems of the body.114,115 For example, when fat is burned, heat and energy are released. If a lack of certain minerals exists, energy levels will drop. Minerals help to transport needed nutrients to depleted areas of the body, thereby stemming off the fatigue we so often experience after eating a fatty meal. Even more importantly, free radicals are released whenever fat is consumed and burned and the presence of chelated minerals helps to expedite the removal of these metabolites and facilitate the availability of fuel for energy. Essential Fatty Acids Prostaglandins control and balance many body functions. The dietary building blocks for making prostaglandins are the essential fatty acids (EFAs). The role of prostaglandins in weight loss has been extensively discussed in a recent review.116 EFAs exert profound lipid-lowering effects.They reduce the synthesis of triglycerides and very low density lipoproteins (bad cholesterol) in the liver. EFA supplementation coupled with a low-cholesterol, low-saturated fat in diet produces a complementary effect in lowering serum lipid levels.117 Garcinia Cambogia ( Hydroxy Cit ric Acid) Garcinia Cambogia contains hydroxycitric acid (HCA). This form of citric acid inhibits the liver’s ability to make fats out of carbohydrates.118 Carbohydrates are converted to glycogen stores, not fat stores, giving the body a better energy reserve and an increase in stamina.119 Ephedra And Thermogenisis Thermogenesis means “creating heat.” This is one of the ways our bodies have of burning off excess calories and maintaining a constant weight.120 This is an area of weight management research that is being intensely studied. When we repeatedly yo-yo diet or abuse ourselves by eating too much, our thermogenic ability may be reduced. Numerous animal and human studies have confirmed the benefits of ephedra and methylxanthines in inducing weight loss and restoring thermogenic responsiveness.43,44,121
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=502) ENDNOTES
Date:
June 23, 2005 11:50 AM
ENDNOTES
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=410) How Does CLA Work?
Date:
June 22, 2005 09:46 PM
How Does CLA Work? How could CLA hinder the growth and development of certain cancers in animals? Scientists have developed some intriguing possibilities, and many of them are related to the theory of antioxidants. WHAT IS AN ANTIOXIDANT? Well, one of the ironies of life is that oxygen, so essential to human life, also causes decay. Look at the parts of your car where paint may have pealed away, and you will notice rust, what scientists call oxidation. Molecules of oxygen combine with the iron or chromium on your car and change its chemical alignment to iron oxide or chromium oxide—rust. In a very real sense, the same thing happens to you as you age. Inside your cells, thousands of chemical reactions take place each moment. These reactions break apart the long chains of carbon, oxygen and hydrogen that make up body tissues and combines them in new ways. Some of those combinations cause decay. One example is when a free radical—a single atom of roaming oxygen—attaches itself to something useful, rendering it useless or even dangerous. If a free radical were to change DNA, for example, that could mutate a cell. This free radical process is one way this oxidation occurs, and antioxidants, often called free radical scavengers, attach themselves to the free radicals, blocking their damage. This can help improve life and help to cut the problems of oxidation. Indeed, many see antioxidants as a way of lessening the risks of cancer. Many people know about important antioxidants, such as ascorbigen (vitamin C), selenium or alpha tocopherol (vitamin E), but nature provides numerous antioxidants. Many exciting ones are emerging, such as proanthocyanidins (often known as pycnogenol), quercetin (common in many fruits) and selenium (a mineral). C LA may be another antioxidant emerging from the research. Dr. Pariza and others found in a 1991 experiment that in the test tube, CLA was effective in battling free radicals. 28 It helped prevent damage to the DNA inside the cells. Pariza says in another paper, “Our hypothesis is that the antioxidant activity of CLA may at least in part explain its anticarcinogenic effect.”29 That would mean that one way CLA prevents cancer is because it blocks these dangerous free radicals. (Other theories about how it fights cancer include breaking down the chemicals that cause cancer into others that don’t .30 All the theories may be true in specific situations, and none might.) But like many other emerging, exciting areas of scientific inquiry, this idea that CLA is an antioxidant has doubters. Researchers J.J. van den Berg, N.E. Cook and D.L. Tribble wanted to see if CLA protected fatty membranes comprised of a substance called palmitoyl-2-linoleoyl phosphatidylcholine (PLPC) from the damage of biologic oxidation. In research published in 1995, they compared CLA’s effect to the wellknown antioxidant vitamin E. While vitamin E protected well, CLA did relatively little. They also found that CLA did not become a mineral chelator, an agent that helps natural minerals become available biologically. They bluntly said, “On the basis of our observations, a role for CLA as an antioxidant does not seem plausible.”31 Another study in 1995, however, showed that CLA can break down into other substances, called feran derivatives, that do act as antioxidants.32 As in all emerging sciences, debates ensue among honest, dedicated researchers. CLA may not, itself, be a antioxidant. Perhaps it acts as antioxidant in only certain situations. Perhaps things that come from CLA act like antioxidants. That is the state of the research today. (Indeed, Dr. Pariza says such debates are common in the field of antioxidants. 33) What is important to remember is that in numerous animal Models, CLA protected against the dangers of many different kinds of cancer in animals, and that, according to scientists, it is one of the most potent cancer-preventing substances of its kind known to science. Whether the cause of this effect was because of CLA or because of some other reason really isn’t that important. Another thing to remember is that CLA is not a cancer drug. It is something that would be useful in addition to other cancer treatments. It is something to consider to lower your risks and, perhaps, lessen the effects of treatment. It should not be considered a treatment option on its own.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=394) CLA and Cancer
Date:
June 22, 2005 09:44 PM
CLA and Cancer Because of Pariza’s 1979 research, some of the earliest studies done on CLA were to see if it could block the development of cancer. Dr. Pariza and his colleagues at the University of Wisconsin/Madison’s Food Research Institute in Madison took extracts from beef that they knew had “mutagen modulators” (this was before they isolated CLA.).15 They took two groups of mice, to one they applied this extract on their skin. On the other group, they did not apply the extract on the skin. Then, on both sets, researchers put a cancer-causing substance called dimethylbenaanthracene—DMBA for short—and applied it to the skin. Sixteen weeks later, doctors counted the mice that had tumors and how many tumors each of those mice had. The number of mice with tumors was 20 percent lower when given the beef extract, and, significantly, the numbers of tumors on those mice that did develop cancer was half what it was on the untreated mice. This meant that this extract could, perhaps, prevent some cancers in mice and, slow tumors after they develop. (Today, Pariza writes that CLA inhibits cancer development at various stages, from initiation to metastasis.)16 After isolating CLA by itself, Pariza and others found that CLA also cut the incidence of skin tumors.17 Scientist Clement Ip at the Roswell Park Cancer Institute in Buffalo did a similar study using DMBA with rats, this time feeding different amounts of CLA into the diet and over a longer period of time. He and his team measured how many breast tumors these rats developed. As might have been expected with the earlier work, 20 percent fewer animals developed the tumors—among those receiving the most CLA—than the rats that received none, and the total number of tumors that developed was 60 percent less. In general, the data showed that the more CLA, the greater the protective effect.18 This is significant in the human world because many researchers see a link between a woman’s consumption of fat and her risk of getting breast cancer, and CLA could help modulate that. Any research to lower a woman’s chance of contracting breast cancer is useful. Today in the United States, as many as one in eight will contract the dread disease.19 In 1990, Dr. Pariza and his colleagues also found a lower incidence of cancers in parts of the stomach.20 Rats were given something called 2-amino-3-methylimidazo (4,5-f]quinoline, which can give them colon cancer. Again, the total number of aberrant growths was lower for those given CLA compared with those given safflower oil, which is rich in essential oils but not so high in CLA.21 Does this mean that CLA will prevent cancer in humans? Perhaps. You might even say probably—in some circumstances Still, science can be imprecise in predicting cancers from animal Models to humans, and scientific tests must be controlled in ways that don’t mimic the complexities and confounding factors of daily life. Few of us, for example, will be exposed daily to DMBA. T h e re f o re, all the science says for certain is that CLA seems to hinder the development of cancer in these animals when the cancer is caused by one particular substance. T h a t’s a little way, at least, from saying it pre vents cancers in humans. However, the animal Models are encouraging, and often meet mathematical tests to be “statistically significant.” In fact, scientists have taken to saying CLA has an anti-carcinogenic effect without hedging. Ip himself says, “CLA is more powerful than any other fatty acid in modulating tumor development.” 22 Indeed, so excited have many scientists become that some say one day governments may want to fortify our foods with CLA much the way we fortify our morning bran flakes with vitamin C.23 Furthermore, since at least several ways of giving different species of animals cancer have been studied, and in all of the tests, cancer was hindered, it gives better evidence to the notion that CLA hinders cancer in humans as well. Pariza wrote, “Few anticarcinogens, and certainly no other known fatty acids, are as effective as CLA in inhibiting carcinogenesis in these Models.”24 This is clear language saying scientist believe this to be a powerful nutrient in the war against cancer. However, until human research is completed, and human research is underway, the positive effects of CLA on humans as a possible preventative of cancer best be considered preliminary. Another important point about this is: Since the breakdown and changing of fats and fatty acids like CLA occur in the liver, CLA may have unknown effects on this vital organ. One study showed that fats increase in the livers with the increase of CLA in the diet.25 Could this lead to an increased risk of liver cancer? Scientists do not have a complete answer to that question either.26 Pariza says, however, that such problems of fat accumulation do not occur in higher mammals, and is something specific to mice and some rats.27
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=393) PADMA BASIC: A Tibetan Herbal Formula
Date:
June 21, 2005 05:27 PM
PADMA BASIC: A Tibetan Herbal Formula By Isaac Eliaz, M.D. "As an integrated system of health care, Tibetan medicine can offer allopathic medicine a different perspective on health. However, like other scientific systems, it must be understood in its own terms, as well as in the context of objective investigation. In practice it can also offer Western people another approach to achieving happiness through health and balance." --His Holiness the Dalai Lama, May 16, 1997
In this article I want to discuss a Tibetan-based herbal formula that reflects the philosophy outlined by H.H. the Dalai Lama. PADMA BASIC® is an extensively researched formulation that bridges the gap between Classical Tibetan Medicine and the modern Western medical paradigm. With over 50 published scientific papers spanning the last 30 years, PADMA's popularity among Western medical professionals can be attributed to its history of safe use and its health-enhancing properties. The original formula, used for centuries as a cardiovascular tonic and to counteract "heat" (inflammatory processes or infections), made its way to Europe by the first half of the 20th century. Acceptance of an ancient Tibetan formula into the Western medical tradition requires sensitivity to both the original Tibetan intention, and the rigorous requirements of the international pharmaceutical community. Today PADMA BASIC is produced in accordance with strict manufacturing guidelines. The herbs are grown organically, or meticulously tested to ensure they are not contaminated. Ingredients are verified using thin layer or high pressure liquid chromatography. While the highest "scientific Western methods" are used, traditional Tibetan "scientific methods" of smelling and tasting are also followed. PADMA BASIC can be understood from two viewpoints. In Classical Tibetan Medicine, good health means maintaining a dynamic equilibrium of universal elemental forces. Illness is a manifestation of imbalance. Therapeutic intervention aims at restoring balance by treating the cause, not just the symptoms. Within this traditional Model, PADMA has three functions:
PADMA BASIC Ingredients: Iceland moss (Cetraria islandica), Costus root, neem fruit (Azadirachtaindica), Cardamom fruit, Red Saunders heart wood (Pterocarpus santalinus), chebulic myrobalan fruit (Terminalia chebula), Allspice fruit, bael tree fruit (Aegle marmelos), Calcium Sulfate, Columbine aerial part (Aquilegia vulgaris), English Plantain aerial part, Licorice root, Knotweed aerial part (Polygonum aviculare), Golden cinquefoil aerial part (Potentilla aurea), Clove flower, Spiked ginger lily rhizome (Hedychium spicatum), Valerian root, Lettuce leaf (Lactuca sativa), Calendula flower, Natural Camphor (Cinnammum camphora). Dr. Isaac Eliaz is a medical doctor and licensed acupuncturist with extensive training in complementary modalities. For 15 years, his practice has centered on the integrative treatment of cancer. He has been involved in numerous studies investigating the effects of nutritional supplements on cancer and has been granted two patents.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=389) Are Standardized Herbs Better?
Date:
June 17, 2005 12:34 PM
Are Standardized Herbs Better? Standardized is a term to mean that there is a guaranteed amount of a certain botanical constituent. For example St. John's Wort can be standardized to contain hypercin, Gingko can be standardized to contain flavones, Mahuang for ephedrine, and Milk Thistle for its silymarin content. Standardized does not necessarily mean stronger or better. Chemical solvents such as hexane benzene, acetone, and methyl chloride are typically used in standardized extracts. Residues of the chemicals are found in the finished product. Furthermore they may be hazardous to the environment. The problem with obtaining an amount of a standard constituent is, a plant can contain hundreds of active constituents. By concentrating on one component, we may lose synergistic compounds, which may improve effectiveness and lessen adverse reactions. Often scientists do not fully understand which constituents are beneficial for the clinical results of an herb. For example scientists are unclear whether or not hypercerin, hyperiform, or the interaction of several constituents, that have antidepressant properties in St. John's Wort. Once it was thought that the immune effects of Echinacea were due to echinosides; now it is thought that polysaccharides and proteins may also be immune supporting. In the case of ginseng, ginsenosides are found in ginseng leaves and roots, however ginseng leaves do not have same properties as the roots. In the South Pacific, locals all use Kava Kava roots, however German pharmaceutical companies use the stems to make standardized Kava Kava. Another drawback of standardized herbs is the chemicals used to manufacture them. Advocates of standardized herbs are usually academics with little clinical experience with herbs, or researchers whose work is funded by companies that manufacture standardized products. Traditional herbalists seldom used standardized products for a variety of reasons. One, standardized extracts tend to be more expensive. Two, there is little evidence that they are more effective than the whole herb. For example, I have never seen studies comparing Gingko tea to standardized Gingko extracts; Ginseng standardized extracts have not been shown superior to whole ginseng root. Finally, many herbalists reject the pharmaceutical Model of healthcare, which involves costly production techniques and capital investment to make a standardized extract. Standardized herbs play a role in the drug Model of herbal medicine, however traditional herbalists will continue to recommend herbs in more natural state which may include water and alcohol extracts, teas and pills that have not been standardized. (Factors that influence products quality include weather, soil, the time of year the plant is harvested, the age of the plant, the part of the plant being used, and the DNA of the plant, storage and processing.) You can also blend various batches of herbs to achieve a consistent potency; this is commonly done in the wine making industry. Finally you can add an active compound (synthesized) to an herbal product and the DNA of the plant, storage and processing.) The purpose of this article is not to condemn standardized herbs. It may be a good idea to remember that this form of herbal preparation is just one of many forms.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=372) Vitali-Tea - Tea fits a healthy lifestyle to a T...
Date:
June 13, 2005 09:45 AM
Vitali-Tea by Leah Brinks Energy Times, October 9, 2003 If the research is even only half right, tea fits a healthy lifestyle to a T. Whenever scientists look at a teapot's contents, they find striking health benefits: Heart protection. Reduced cancer risk. Better skin. All of these are apparently in the bag when you choose to drink tea. Tea green, tea black: Which to choose? Actually, both types come from the same plant, Camellia sinensis. Green tea is steamed and dried; black tea is fermented, which allows its darker color to develop. Some lesser-known types include white tea, which is actually green tea that undergoes the most minimal of handling. (Another rare white tea, white cantaloupe, is rich in antioxidants.) Oolong is a tea that falls between green and black in processing and flavor. One increasingly popular tea color, red, is not tea at all, but an herbal brew called rooibos (technically, herbal teas are known as tisanes). This South African plant yields a citrus-flavored beverage high in vitamin C. Other herbs known for yielding flavorful infusions include chamomile, used to promote sound sleep; peppermint, a digestion easer; and rose hips, which, like rooibos, combines healthy vitamin C levels with a delightfully zesty taste. Toxin Blocker The evidence for tea's health benefits has practically boiled over. For instance, researchers at the University of Rochester have found that green tea substances inhibit the action of a molecule irritated by tobacco smoke, a toxin central to tobacco's cancer-causing danger. This action, say the scientists, may be the reasons that smokers who drink tea suffer less cancer (Chem Res Tox 7/21/03). The Rochester researchers found that tea helps protect a cellular molecule called the aryl hydrocarbon (AH) receptor. Ordinarily, AH is frequently disturbed by toxic substances that cause cancer and other illnesses. Tobacco smoke (as well as the pollutant dioxin) interacts with AH to initiate cancer and other problems. But at least two chemicals in green tea-epigallocatechingallate (EGCG) and epigallocatechin (EGC)-interfere with AH's harmful activity. These substances, flavonoids similar to healthful chemicals found in grapes, wine and cruciferous vegetables like broccoli, have been shown to lower cancer risk. "It's likely that the compounds in green tea act through many different pathways," says Thomas Gasiewicz, professor and chair of Environmental Medicine and director of Rochester's Environmental Health Science Center. In the Rochester study, Dr. Gasiewicz and his colleagues found that EGCG and EGC close down the AH receptor in cancerous animal cells and most likely produce the same benefit in human cells. Still to be made clear is how tea is metabolized when the body digests tea, but the Rochester scientists are still peering through their microscopes and teapots to find out. Tea Protection Scientists at the Linus Pauling Institute at Oregon State University have found that drinking green or white tea can significantly lower your risk of colon cancer as well the prescription drug sulindac, which has been shown effective for people at high tumor risk (Carcinogenesis 3/03). "Tea is one of the most widely consumed beverages in the world, and recent upswings in the sales of green tea in the United States can be attributed to reports of potential health benefits against cancer and other chronic diseases," says Gayle Orner, an OSU research associate. "Teas exert significant protective effects in experimental animal Models of skin, lung, esophageal, gastric, hepatic, small intestinal, pancreatic, colon, bladder and mammary cancer." While many people today take aspirin and similar drugs that have been shown to lower cancer risk, this study shows that drinking tea and taking low doses of these drugs, called NSAIDs, can reduce the risk even further. (High doses of NSAIDs, while protective against colon cancer, can cause internal bleeding.) "These are pretty exciting results," Orner says. "What's especially significant is that as far as we can tell consumption of tea has none of the side effects of NSAIDs, which can be severe, including bleeding, ulcers and even death." In this research on animals, use of tea dropped the risk of cancer by about two-thirds. According to the lab results, drinking about three large cups of tea a day should provide significant cancer protection. Based on research in Japan that looked at how green tea lowers the risk of stomach cancer, the Linus Pauling scientists urge plenty of tea drinking: "The more the better." Tea Surprise Studies show that nations of tea drinkers have less trouble with their hearts than residents of places where tea is hardly ever brewed. And now research is starting to zero in on the substances in tea that benefit heart health. A study of 240 Chinese men and women who have high cholesterol has found that chemicals in tea can significantly drop harmful cholesterol (Arch Int Med 6/23/03). "Personally, I was very surprised," says David J. Maron, MD, professor at the Vanderbilt University Medical Center, lead author of the study. "I expected, if anything, a very slight cholesterol-lowering effect. But what we saw was a 16% reduction in low density lipoprotein (LDL) cholesterol." LDL cholesterol is known as "bad" cholesterol because it can increase your risk of heart disease. The researchers in this study gave people extracts of green and black tea enhanced with theaflavin, an antioxidant also found in green tea. In the future, if past results are any indication, tea's rich supply of beneficial chemicals will continue to pleasantly surprise researchers with even more benefits.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=317) Homeopathic Essentials
Date:
June 11, 2005 05:13 PM
Homeopathic Essentials by Jane Lane Energy Times, February 1, 2000 The principles of homeopathy are elegantly basic and, to some, maddeningly elusive. This system of medical treatment employs The Law of Similars or "like cures like," and calls on natural plant, animal and mineral substances that induce the body to heal itself. That homeopathy works is virtually incontrovertible. With its ancient roots and European practice spanning hundreds of years, homeopathy employs minute doses of diluted extracts to replicate symptoms of a malady, which then vanishes. But the very fact that it works puzzles many experts who have researched the phenomenon. Understanding The Tradition Homeopathy evolved from its earliest practice recorded by 10th-century BC Hindu sages to its codification by Hippocrates in 400 BC. " Through the like, disease is produced and through the application of the like, it is cured," he wrote, expressing the fundamental principle of homeopathy, according to Homeopathic Medicine at Home (Tarcher Perigee) by Maesimund B. Panos, MD, and Jane Heimlich. Samuel Christian Friedrich Hahnemann, the erudite and intellectually audacious German physician and chemist, seized upon the essentials of homeopathy in the early 1800s. Through Hahnemann's work, homeopathy developed into an intricately systematized science, veering into the arcane for the contemporary individual seeking relief for everyday ailments. Modern practitioners and manufacturers of homeopathic remedies benefit from Hahnemann's daring research (which included potentially lethal experiments on himself) and complex doctrines. They've streamlined and modernized Hahnemann's concepts to provide more relevance to modern ills and sensibilities. The Bold Experiments Hahnemann denounced the medical practices of the 18th century, which involved cauterizing, bleeding, blistering and purging patients to expel the pernicious fluids or humors believed to cause disease. He also reviled the kind of omnibus prescription drugs of the day, which loaded many substances into one compound. In 1790, Hahnemann conducted his groundbreaking experiment establishing the basis of homeopathy. The customary treatment for malaria at the time was Cinchona officinalis or Peruvian bark-quinine. Medical wisdom attributed its efficacy to its bitterness and astringency. Hahnemann rejected this explanation, noting that other botanicals are far more bitter and astringent, yet are powerless against malaria. To prove his theory, Hahnemann took some cinchona compound and promptly developed the symptoms of malaria. His deduction: Like cures like, or The Law of Similars. A substance that, in minute doses, induces certain symptoms in a healthy person cures a sick one. The Set of Laws A set of fairly complex laws developed from Hahnemann's initial Law of Similars. The Law of Proving refers to the process of ascertaining the effectiveness of a homeopathic therapy by administering a substance to a healthy person to record in minute detail its effects. Practitioners also use the standard double-blind method using a placebo or unmedicated tablet against a homeopathic compound. The first proving was performed in 1790 and the procedure endures today, using only humans, not laboratory animals, for greater accuracy. As homeopathic preparations are not toxic, proving has never produced lasting adverse reactions. Descriptions of provings are compiled into books called materia medicas, including Boericke's Materia Medica and Repertory and The Lectures of Homeopathic Materia by James Tyler Kent, used regularly in contemporary practice. The books are highly indexed collections of symptoms and the remedies that cure them called repertories. The most extensively used repertory is Kent's Repertory of the Homeopathic Materia Medica. In 1800, the third Law of Potentization was devised, regulating the processing of homeopathic remedies through successive dilutions and shaking. This law represents perhaps the profoundest mystery of homeopathy and demands the boldest leap of faith: The higher the dilution, the more intense the potency of the medicine. Substances that are inert in their natural state act as medicine. And as they are so dilute, homeopathic remedies do not act directly on the tissues, accounting for their non-toxicity. Adding to the inherent safety of homeopathic therapies is the discipline's adherence to the single remedy. Centuries ago, homeopaths seemed to have been prescient about current drug interaction troubles. (Historical information courtesy of Homeopathic Medicine at Home by Panos and Heimlich.) How It Works: The Vital Force Homeopathy embraces a philosophy centered on the concept of "vital force," an intelligent, dynamic life force within each individual responsible for maintaining one's life and balance on all levels. The vital force creates a defense mechanism similar to the immune system, but incorporates protection against imbalances on the emotional and mental planes as well. Homeopathy equates disease with imbalance. As the defense mechanism attempts to restore balance, symptoms appear: pain, swelling, rashes and fevers on the physical side; grief, jealousy, anxiety, anger, confusion and loss of memory on the emotional and mental end. Homeopaths regards these symptoms as evidence of the vital force's curative exertions, not merely annoyances to be eliminated. Symptoms guide the homeopath in his or her attempts to harmoniously augment the efforts of the vital force. Homeopathy Today Homeopathic remedies are prepared according to the standards of the United States Homeopathic Pharmacopoeia and are recognized by the US Food and Drug Administration. " Homeopathy respects the complexity and uniqueness of each individual," observes pharmacist and naturopathic doctor James LaValle (and his co-authors) in Smart Medicine for Healthier Living. "To identify the correct homeopathic remedy, you must carefully observe your unique-even quirky-behaviors and responses." Indeed the emphasis on the "unique, even quirky" may lead to the perception of homeopathy as a sketchy pseudo-science. Homeopathy simply does not fit the drug Model of allopathic medicine. Its ability to help people, however, has been repeatedly evaluated through rigorous scientific research. A comprehensive review in the British Medical Journal (302, 1991: 316-323) of more than 100 clinical studies of homeopathy published during the last 30 years revealed that 77% of those studies produced positive results for the people involved. A host of additional studies provides clinical evidence:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=295) Bone Power - Natures Plus
Date:
June 11, 2005 04:41 PM
Bone Power by no author Energy Times, May 1, 1997 Patricia Q. stopped smoking 20 years ago. At 61, she is active, tries to exercise regularly, eats properly and takes a multivitamin. Most would consider Patricia's lifestyle a sufficient safeguard against the diseases of aging. But one debilitating possibility still concerns her: Osteoporosis-bone thinning. She worries that her bones may have begun weakening almost a decade ago. Although her good health habits can slow the demineralization of her bones, osteoporosis may still take its toll. And as her neck and back begin to obviously round, a possible sign of bone weakness, Patricia frets about her future. The weakening of bones brought on by age makes them more prone to fracture. One of every two women older than age 50 suffers an osteoporosis-related fracture during her lifetime. Osteoporosis literally means "porous bones," bones that deteriorate and particularly increase the risk of damage to the hip, spine and wrist. In extreme cases, everyday activities assume danger: fractures can result from simply lifting a bag of groceries or from what would otherwise be a minor fall. Some women, fearful of fractures, eliminate many seemingly innocuous activities from their daily lives. Their fear is well founded. Complications from these fractures are a major killer of women. As women grow older, the risk grows, too. Ten million individuals already have the disease, and 18 million have low bone mass, placing them at risk for osteoporosis. But research shows that osteoporosis may be preventable and controllable. Regardless of age, eating right, getting enough calcium and performing weight-bearing exercises, can lower your risk for this disease. Understanding Your Bones Bones are not static structures but living tissue constantly reformed in a process called reModeling. Every day old bone is removed and replaced with new bone tissue. When more bone is broken down than is replaced (demineralization), bones weaken. When the structure loses sufficient density, you face eminent danger of a fracture. Generally speaking, bones continue to increase their density and calcium content until you reach your 30s, at which point you probably have attained your peak bone mass. Afterward you may either maintain this mass or begin to lose calcium yearly, but you rarely can increase bone density. The loss of bone density can increase at menopause, when your body ceases producing estrogen, a hormone required to improve bone strength. In addition, some medications, used for a long period, compromise bone density. Stop Calcium Loss Eating a diet rich in nutrients that help your bones stay strong should be the first step in stopping or slowing the process of osteoporosis. Calcium, magnesium, vitamin D, phosphorus, soy-based foods and fluoride compose the major nutrients that strengthen bone. At this moment, 98 percent of your body's calcium resides in your bones, the rest circulates in the blood, taking part in metabolic functions. Because the body cannot manufacture calcium, you must eat calcium in your daily diet to replace the amounts that are constantly lost. When the diet lacks sufficient calcium to replace the amount that is excreted, the body begins to break down bone for the calcium necessary for life-preserving metabolic processes. Calcium in the diet can generally slow calcium loss from bones, but it usually doesn't seem to replace calcium already gone. The National Institutes of Health recommend 1000-1200 milligrams of dietary calcium per day for premenopausal women and 1200-1500 milligrams for menopausal and postmenopausal women Good sources of calcium include milk and milk products, yogurt, ricotta, cheese, oysters, salmon, collard greens, spinach, ice cream, cottage cheese, kale, broccoli and oranges. If you cannot tolerate dairy products, calcium supplements are an easy way to consume calcium. Take supplements with a meal to aid absorption of calcium from the stomach. In Total Health for Women, Dr. Kendra Kale, clinical assistant professor of medicine at the University of Pennsylvania School of Medicine, urges women to read supplement labels. Scrutinize the fine print to see how many grams are considered "elemental"or "bioavailable"-the form of calcium your body will absorb. If you're taking a 750 milligram supplement, chances are only 300 milligrams are elemental. You should also check that the pill will dissolve within 30 minutes and meets the United States Pharmacopoeia (USP) standards. If tablets do not break down within 30 minutes, they may pass through you unabsorbed and you won't digest the calcium from them that you need. Absorbing calcium from your digestive tract also requires the presence of vitamin D. Ten to 15 minutes of sun exposure daily usually satisfies vitamin D requirements since most people's bodies can use sunlight to manufacture this substance. So walking to work, or going outside for lunch should supply sufficient ultraviolet light to facilitate calcium absorption. As we age, however, our body's ability to produce vitamin D gradually diminishes. Our diets can make up the difference: Good dietary sources of vitamin D include egg yolks, liver and fish or nutritional supplements. Many foods, like milk, are supplemented with vitamin D. Magnesium is another mineral that helps to build bones. Found in leafy, green vegetables, nuts, soybeans, seeds and whole grains, your daily requirement of magnesium should be about half of your calcium intake. Absorbing calcium for bone health also requires phosphorus, but be careful not to get too much of a good thing: excess phosphorus can actually increase your body's need for calcium. This can present a problem for people who drink bottle after bottle of cola soft drinks or who eat an abundance of processed foods which are often high in phosphorus. New Soy Research New research suggests that soy foods, like tofu or soy milk may be vital for preserving bones. A study of more than 60 postmenopausal women who consumed either diets rich in soy's isoflavones or milk protein found that eating soy restored calcium to some of the women's bones. Even though the researchers didn't think such a replacement due to soy was even possible! The researchers at the University of Illinois believe that isoflavones behave in the body in some of the same ways that estrogen does. The study measured bone density at the lumbar spine, a part of the body at the small of the back that is liable to fractures due to osteoporosis. Fluoride: Not Just For Teeth Although most people associate the mineral fluoride with strong teeth, fluoride is just as important for bone strength. Surveys report that osteoporosis is reportedly less common in communities that drink fluoridated water. Fluoride combines with calcium in the bones to slow mineral loss after mid-life. Good sources of this mineral include fish, tea and most animal foods. Cut Back on Alcohol and Coffee According to the National Osteoporosis Foundation, consuming lots of caffeine is thought to increase the calcium excreted in your urine. In addition, high levels of protein and sodium in your diet are also believed to increase calcium excretion. And although more studies of protein and sodium are needed to precisely determine how these substances influence calcium loss you should limit the caffeine, protein and salt you take in. On top of those findings, researchers say that the diuretic action of alcohol and caffeine speed skeletal calcium loss. They believe alcohol may interfere with intestinal absorption of calcium. Pumping Up Along with a bone-friendly diet, your exercise program should also be designed to preserve bone. Weight-bearing exercise-exercise that places stress on the bones-strengthens bone density and wards off osteoporosis. Weight-bearing exercises include weight lifting, walking, jogging and jumping rope. Exercise possesses many benefits for preserving bone, according to Miriam Nelson, Ph.D., author of Strong Women Stay Young. Among them: exercise can help you retain the balance necessary to resist falls and strengthen the muscles that keep you erect. Studies performed on women of all ages found that by doing strength training exercises two times a week for a year, without use of estrogen or hormone replacement therapy (HRT), women, on average, added three pounds of muscle and lost three pounds of fat. They were also 75 percent stronger with improved balance and bone density. Although strength training can be performed by anyone at any age, Nelson recommends that if you have an unstable medical condition or if you have recently undergone surgery, wait until you recover and speak with your doctor before beginning an exercise program. If you have not exercised in a long time, consult a health practitioner knowledgeable in sports medicine before beginning an exercise program. Other Options Drug therapies are now available to combat osteoporosis. One of the most popular is HRT, which supplies estrogen to women undergoing menopause. However, medical experts are still arguing over HRT 's possible role in increasing your risk of cancer, particularly breast cancer. According to Jan Rattner-Heilman, co-author of Estrogen, the Facts Can Change Your Life, the conflicting studies that balance the benefits and risk of HRT are bound to confuse the average consumer. Estrogen is recommended to prevent bone loss and forestall heart disease and possibly Alzheimer's disease. Most women take estrogen to ease the discomforts of menopause such as hot flashes, and many experts do not believe that it unduly increases the risk of breast cancer for those at low risk. Heilman warns, however, that estrogen probably should not be taken by women especially at risk for breast cancer risk or those who are already suffer the disease. Patricia Q. is reluctant to try HRT. "I'm at risk for breast cancer-my mother had it-so I won't take estrogen. I'd rather do what I can without medications. My preference is to watch my diet and exercise as much as I can. That gives me my best chance to avoid osteoporosis." Doctor Nelson agrees with this perspective She believes that exercise possesses enough benefits to make it the treatment of choice. "The difference between estrogen and strength training is that strength training has a huge spillover effect; you aren't just decreasing one type of disease. You become stronger with more muscles and less fat, and you become more fit. This decreases your chances for many types of diseases, not just osteoporosis. It can decrease risks for heart disease, diabetes, sleep disturbances, hypertension and more." If you believe you are at risk for osteoporosis, ask your doctor about the benefits of bone mineral density screening. DEXA scan (dual energy x-ray absorptiometry) measures the bone density in a 15-minute test. But the test is expensive: the cost of this test ranges from $75-200 or more and may not be covered by your health insurance. But financial help may be on the way. A Bone Mass Standardization Act has been introduced in Congress to ensure that the cost of bone mass measurement is covered under Medicare and that standards for coverage are clear and consistent for anyone with medical insurance. Fighting Osteoporosis at Different Ages Childbearing years (30-40): These years are particularly important for preserving bone through exercise and good nutrition. Eat plenty of low-fat dairy products, vegetables and soy. Perform weight-bearing exercise such as walking, jogging and weight lifting to attain the greatest amount of bone and muscle possible. Being active reduces risk of injury and makes you stronger. If you smoke, now's the time to stop. Menopausal years (late 40s-50s): During this time, muscle, bone and estrogen decreases. Minimize loss through diet, walking and weight lifting. Your exercise intensity may have to be decreased but you should not stop being physically active. Post Menopause (over 60): Focus on reducing your risk of falling. Minimize balance problems and increase muscle strength through exercise.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=291) Improove Memory ...
Date:
June 09, 2005 05:49 PM
Mesmerizing Memory by Cal Orey Energy Times, January 1, 1999 In the 60s, the same rock 'n' rollers who belted out "One pill makes you larger and one pill makes you small," often espoused the belief that certain pills could expand the mind. While counter-culture pill purveyors were pilloried for their pill-popping claims, 90s nutritional research has uncovered a stash of supplements that may amplify mental improvement. Like a blues singer bending a high note, researchers are now humming with dramatic assertions that certain nutritional supplements can sustain and enhance concentration and memory function. For instance, studies reveal possible benefits for cognitive powers from vitamin C, magnesium and Ginkgo biloba. A recent report in the Journal of the American Medical Association (JAMA 278:1327-1332) said that an extract of Ginkgo biloba "can stabilize and, in some cases, improve the cognitive function and social behavior of demented patients." A researcher in the Proceedings of the National Academy of Sciences noted that a daily dose of vitamin E may "help protect the brain and its memories from the ravages of time." And the beat goes on: other evidence indicates that zinc, iron and boron may pump up short-term memory attention span and cut the time it takes to perform mental tasks.
Neuronutrients Lester Packer, PhD, professor of molecular and cell biology at UC Berkeley, told a joint 1996 United Nations-World Health Organization conference on Aging that "there is a growing body of evidence indicating that the free radical theory of aging and aging-related disease is valid," and that dietary and supplemental antioxidants can help fight illness and mental deterioration. Vitamin E and other memory aids are believed to protect brain chemicals called neurotransmitters, "the ferrymen of the brain's communication system," that influence concentration and memory. Experts say that sustaining the level of these nerve chemicals in the brain can potentially improve all mental processes.
Brain Well-Being Too much alcohol, for example, commonly causes progressive mental decline, according to Secrets of the Superyoung (Villard) by David Weeks and Jamie James. The authors also point out that "the memory tends to worsen noticeably after 15 years of alcohol drinking, and much sooner in people who go on massive binges." "The effects of cigarette smoke are subtler because the poisonous effects of carbon monoxide in each puff are temporarily offset by the alerting effects of the nicotine," they add. Can't remember the name of that singer cavorting in a music video? Tests have shown that smokers are worse at connecting peoples' names to their faces than nonsmokers.
Cognition Ignition n Learn something new: A second language, musical instrument, or unique puzzles and games keep neurons working like new. n Turn off the TV: Read. Studies show that passively watching TV requires less concentration than eating cereal. Mental rejuvenation also requires physical activity. Exercise increases oxygen flow to the brain, which supports memory, concentration and cognition. One study has shown that exercise significantly brightened the moods of middle-aged and older women, regardless of whether they were pre- or post-menopausal, with or without hormone replacement therapy.
Supplemental Brain Help Antioxidants, including the previously mentioned vitamin E (You haven't forgotten vitamin E already, have you?), provide crucial help for vigorous cerebral function. The free radicals created by tobacco smoke, air pollution, ultraviolet light and certain carcinogenic chemicals deconstruct cell membranes and may foster microscopic brain cell havoc. Antioxidant enzymes convert free radicals to more neutral, benign substances and nutritional antioxidants can neutralize free radicals by linking up with them. Vitamin C, a brainy antioxidant all star, performs so well that, according to Dr. Khalsa, its levels in the brain are almost 15 times higher than in other parts of the body. This nutrient, he asserts, aids mental and physical longevity. In a UCLA study, people who ingested at least 300 mg of vitamin C daily lived more than six years longer than those who ingested less.
Mental Fat Added to this mix, magnesium also scavenges free-radicals, according to Dr. Khalsa. Plus, experts recommend grape seed extract (phytochemicals that protect a wide range of cellular structures) to safeguard nerve cells and mental capacity.
B Vitamins for the Mind
Iron Mind Boron plays a crucial part in mental function. Scientists at the USDA's Human Nutrition Research Center have linked boron deficiencies to chronic lethargy and fatigue. In brain studies, they found that the electrical activity of the gray matter in the boron deficient indicated increased drowsiness and mental sluggishness.
Huperzine Boost HupA basically protects the brain from free radical damage (due to low levels of antioxidant defenses) and maintains or enhances crucial neurotransmitter action. More specifically, HupA helps reduce the breakdown of acetylcholine, the vital neurotransmitter, and makes this substance more bioavailable. In addition, HupA helps make choline accessible to the brain for the synthesis of acetylcholine, according to a study in Neuropharmacology (30, 1991: 763-768). Normally, the brain manufactures sufficient levels of the chemical phosphatidylserine, a lecithin-derivative that helps boost neurotransmitter release, but deficiencies of vitamin B12 and folic acid, or of essential fatty acids, may retard that production. Low levels of phosphatidylserine in the brain are related to impaired mental function and depression in the elderly. Scientists reporting in Aging (5, 1993; 123-33) describe "good results" using phosphatidylserine in the treatment of age-related cognitive ills.
Ginkgo Brain Power Another ingredient in what seems like an alphabet-soup of brain nourishment is DHA (docosahexaenoic acid), an omega-3 fat essential for normal brain function. Researchers met recently at The New York Hospital-Cornell Medical Center's Nutrition Information Center to discuss "Keeping Your Brain in Shape: New Insights into DHA." Their findings revealed links between low levels of DHA and Alzheimer's, depression, memory loss, attention-deficit/hyperactivity disorder (ADHD) and certain behavioral traits including aggression and hostility.
Mostly Fat Researchers from the National Institutes of Health point out, however, that fish is an excellent dietary source of DHA. In their studies, they discovered that depression rates in Japan and Taiwan, where fish ranks a top spot on the menu, are significantly lower than in North America and Europe. DHA also is crucial to the neurological development of children, according to findings published in Pediatrics (vol. 101, no. 1, January 1998). Researchers suggest that DHA-rich breast milk should be the Model for infant formulas that enhance babies' neurological development. Scientists also have correlated some behavioral problems in children-ADHD, for example-to DHA deficiencies. If you are a vegetarian, or have other cause for concern about a potential lack of DHA in your diet, you can rely on dietary supplementation of DHA. Bruce J. Holub, PhD, of the University of Guelph in Canada provided vegetarians in his research project with DHA supplements over a 42-day period and substantially increased their DHA blood levels. The bottom line to enhanced mental performance is to take a balanced approach, says Robert Snider, MD, who specializes in preventive medicine in Massena, New York. "Maintaining brain power includes exercise, stress reduction and good nutrition." The message to keep in mind: Don't lose your nutritional balance or you could lose a piece of your peace of mind. Recommended Reading: & Brain Builders (Reward Books, 1995), by Richard Leviton. Brain Longevity (Warner Books, 1997), by Dharma Singh Khalsa, MD. Omega 3 Oils to Improve Mental Health, Fight Degenerative Diseases and Extend Life (Avery, 1996), by Donald Rudin, MD, and Clara Felix. Successful Aging (Pantheon, 1998), by John W. Rowe, MD, and Robert L. Kahn, PhD.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=261) The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease
Date:
June 09, 2005 05:22 PM
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease Presented at the 2005 World Garlic Symposium
Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005. “For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.” Presentation highlights included:
Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.
“Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.” Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. . Abstracts PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892 Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout Models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders. INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events. INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.
Bibliographies David Heber, MD, PhD, FACP, FACN Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center Matthew Budoff, MD, FACC Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=257) Red Yeast Rice For Lipid Wellness
Date:
June 04, 2005 02:30 PM
Maintaining cardiovascular health is a fundamental strategy in the holistic healing system. It may be the most important thing you can do for your body. One of the factors for optimal cardiovascular health is keeping your lipid levels within the normal range. But with today’s fast-paced lifestyle, it’s hard to maintain a healthy diet and exercise program. Red yeast rice is a natural product that supports maintenance of normal lipid levels. Source Naturals RED YEAST RICE is standardized to 1.5% mixed mevinolinic acid monacolins. These monacolins block the synthesis of lipids in the liver by binding to the lipids production enzyme HMG-CoA reductase. Support your lipid wellness with the quality and science of Source Naturals RED YEAST RICE. The Liver and Lipid The amount of lipid you consume in food is not the most important factor for regulating normal lipid levels. The liver manufactures approximately 80% of total body lipid while the other 20% comes from dietary sources. Our bodies require lipid but we can also get too much of it. Lipid is only harmful to us if it becomes oxidized. Oxidized lipid can cause damage to tissues and accumulate in blood vessels. Balancing the lipid produced by your liver is critical to your total lipid and your cardiovascular health. Red yeast rice has been used in China for centuries to make rice wine, to color and flavor foods such as Peking duck and as a health promoting food. It is prepared by fermenting a type of yeast (Monascus purpureus) over rice. Red yeast rice is a complex product that contains several active ingredients including monacolins. Monacolins act as HMG-CoA inhibitors. HMG-CoA reductase is an enzyme that helps make lipid. By blocking its lipid producing action, the natural compounds in red yeast rice can help you maintain lipid levels that are within the normal range. A double blind clinical trial using red yeast rice and placebo with 80 human subjects was conducted at UCLA. After eight weeks with no changes in diet composition the group taking red yeast rice maintained healthy lipid levels. Natural Support For Your Heart Nature provides us with special compounds that allow us to explore safe alternatives to support our health. Taking personal responsibility for your health is at the heart of the wellness revolution. Changing your lifestyle is one of the most effective ways to take that responsibility and provide support and protection for your heart. A diet low in lipid, saturated fats and trans-fatty acids, and high in complex carbohydrates and fiber is important. Exercise regularly, quit smoking and supplement your diet with heart-healthy compounds such as red yeast rice, CoQ10, folic acid, garlic, omega-3 fatty acids, carnitine, hawthorn berry extract, arginine, vitamin E and tocotrienols. Source Naturals RED YEAST RICE is standardized to 1.5% mixed mevinolinic acid monacolins. This standardization process provides you with the assurance that you are getting a consistent concentration of these compounds in each dose. RED YEAST RICE is part of Source Natural’s extensive line of products scientifically formulated to provide support for your cardiovascular health.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=191) Calcium D-Glucarate and Tumors
Date:
May 27, 2005 09:40 AM
Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Walaszek Z; Hanausek-Walaszek M; Minton J P; Webb T E Carcinogenesis (1986 Sep), 7(9), 1463-6. Journal code: 8008055. ISSN:0143-3334. United States. Journal; Article; (JOURNAL ARTICLE) written in English. PubMed ID 3091283 AN 86298867 MEDLINE Abstract Using as a criterion the inhibition of serum beta-glucuronidase activity, dietary calcium D-glucarate is shown to serve as an efficient slow-release source in vivo of D-glucaro-1,4-lactone, the potent endogenous inhibitor of this enzyme. Using the 7,12-dimethylbenz[a]anthracene Model of mammary tumor induction in rats it is shown for the first time that feeding the rats calcium D-glucarate-supplemented diet after treatment with the carcinogen, inhibits tumor development by over 70%. Supportive evidence is presented for the theory that calcium D-glucarate inhibits or delays the promotion phase of mammary carcinogenesis by lowering endogenous levels of estradiol(estrogen) and precursors of 17-ketosteroids. Therefore, dietary glucarate can be used to lower blood and tissue levels of beta-glucuronidase, and in turn of those carcinogens and promoting agents which are excreted, at least in part, as glucuronide conjugates.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=111) Glycerylphosphorylcholine -- Supports Cognitive Function in AD ...
Date:
May 24, 2005 09:52 AM
Cognitive Improvement in Mild to Moderate Alzheimer's Dementia After Treatment with the Acetylcholine Precursor Choline Alfoscerate: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial Maria De Jesus Moreno Moreno, MD Instituto Nacional de la Senectud, Mexico City, Mexico
in both men and woman they consistently improved after 90 and 180 days versus baseline with adiministration of GPC three times a day, whereas in the placebo group they remained unchanged or worsened. Statistically significant differences were observed between treatments after 90 and 180 days. Keypoints: references: Bartus RT, Dean RL III, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction, Science. 1982;217:408-414. 2. Larson EB, Kukull WA, Katzman RL. Cognitive impairment: Dementia and Alzheimer's disease. Annu Rev Public Health. 1992;13:431-449. 3. Hofman A, Rocca WA, Brayne C, et al, for the European Prevalence Research Group. The prevalence of dementia in Europe: A collaborative study of 1980-1990 findings. Int d Epidemiol. 1991;20:736-748. 4. Blackwood W, Corsellis JAN, eds. Greenfield's Neuropathology. 3rd ed. London: Arnold; 1976. 5. Geldmacher DS. Cost-effective recognition and diagnosis of dementia. 5emin Neurol. 2002;22:63-70. 6. Perry EK, Tomlinson BE, Blessed G, et al. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. BMJ. 1978;2:1457-1459. 7. Perry EK. The cholinergic hypothesis--ten years on. Br Med Bull. 1986;42:63-69. 8. Giacobini E. From molecular structure to Alzheimer therapy. Jpn d Pharmacol. 1997;74:225-241. 9. Giacobini E. Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: From tacrine to future applications. Neurochem Int. 1998;32:413-419. 10. Brinkman SD, Smith RC, Meyer JS, et al. Lecithin and memory training in suspected Alzheimer's disease. J Gerontol. 1982;37:4-9. 11. Davis E, Emmerling MR, Jaen JC, et al. Therapeutic intervention in dementia. Crit Rev Neurobiol. 1993;7:41-83. 12. Amenta E Parnetti L, Gallai V, Wallin A. Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropiate approaches? Mech Ageing Dev. 2001;122:2025-2040. 13. Sigala S, Imperato A, Rizzonelli P, et al. k-Alpha-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat. Eurd Pharmacol. 1992;211:351-358. 14. Govoni S, Battaini E Lucchi L, et al. Effects of alpha-glycerylphosphorylcholine in counteracting drug-induced amnesia: Through cholinergic and non-cholinergic mechanisms [in Italian]. Basi Raz Ter. 1991;21:75-78. 15. Canonico PL, Nicoletti F, Scapagnini U. Neurochemical and behavioral effects of alpha-glycerylphosphorylcholine [in Italian]. Basi Raz Te~ 1990;20: 53-54. 191 CLINICAL THERAPEUTICS ® 16. Parnetti L, Amenta E Gallai V. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: An analysis of published clinical data. Mech Ageing Dev. 2001;122:2041-2055. 17. Venn RD. The Sandoz Clinical Assessment-Geriatric (SCAG) scale. A general-purpose psychogeriatric rating scale. Gerontology. 1983;29:185-198. 18. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res. 1991;19:330-341. 19. Frattola L, Piolti R, Bassi S, et al. Multicenter clinical comparison of the effects of choline alphoscerate and cytidine diphosphocholine in the treatment of multi-infarct dementia. Curt Ther Res Clin Exp. 1991;49:683-693. 20. Muratorio A, Bonuccelli U, Nuti A, et al. A neurotropic approach to the treatment of multi-infarct dementia using L-c~-glycerylphosphorylcholine. Curt Ther Res Clin Exp. 1992;52:741-75l. 21. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: APA; 1994. 22. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-944. 23. Folstein ME Folstein SE. "Mini-mental state": A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12:189-198. 24. Loeb C, Gandolfo C. Diagnostic evaluation of degenerative and vascular dementia. Stroke. 1983;14:399-401. 25. Hamilton M. A rating scale for depression.J Neurol Neurosurg Psychiatry. 1960;23:56-62. 26. Hamilton M. Development of a rating scale for primary depressive illness. BrJ Soc Clin Psych& 1967;6:278-296. 27. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. AmJ Psychiatry. 1984;141:1356-1364. 28. Reisberg B, Ferris SH, De Leon MJ, et al. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry. 1982;139:1136-1139. 29. National Institute of Mental Health. Clinical global impressions. In: Guy W, ed. ECDEU Assessment for Psychopharmacology. Revised edition. Rockville, Md: National Institute of Mental Health; 1976:217-222. 30. Burns A, Russell E, Page S. New drugs for Alzheimer's disease. Br J Psychiatry. 1999;174:476-479. 31. Kumar V, Anand R, Messina J, et al. An efficacy and safety analysis of Exelon in Alzheimer's disease patients with concurrent vascular risk factors. Eur J Neurol. 2000;7:159-169. 32. Knapp MJ, Knopman DS, Solomon PR, et al, for the Tacrine Study Group. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA. 1994;271:985-991. 192 M. Moreno 33. Lindstrom MJ, Bates DM. Newton-Rapshon algorithms for linear-mixed effects Models for repeated measure data. J Am Stat Assoc. 1998;83:1014-1022. 34. Thai LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neurology 1996;47:705-711. 35. Rogers SL, Friedhoff LT, for the Donepezil Study Group. The efficacy and safety of donepezil in patients with Alzheimer's disease: Results of a US multicentre, randomized, double-blind, placebo-controlled trial. Dementia. 1996;7:293-303. 36. Rogers SL, Doody RS, Mohs RC, Friedhoff LT, for the Donepezil Study Group. Donepezil improves cognition and global function in Alzheimer disease: A 15-week, double-blind, placebo-controlled study. Arch Intern Med. 1998; 158:1021-1031. 37. Corey-Bloom J, Anand R, Veach J, for the ENA 713 B352 Study Group. A randomized trial evaluating the efficacy and the safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease. Int J Geriatr Psychopharmacol. 1998;1:55-65. 38. Rosler M, Anand R, Cicin-Sain A, et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease: International randomised controlled trial. BMJ. 1999;318: 633-638. 39. Amenta E Bronzetti E, Del Valle M, Vega JA. Effects of alpha-glycerylphosphorylcholine in neuroanatomy of aging brain in experimental animals [in Italian]. Basi Raz Te~: 1990;20:31-38. Address correspondence to: Scientific Department, Italfarmaco SpA, via dei Lavoratori 54, 20092 Cinisello Balsamo, Milan, Italy.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=98) Milk Thistle and Liver Damage abstract ...
Date:
May 22, 2005 04:32 PM
Silymarin Protects Against Liver Damage in BALB/c Mice Exposed to Fumonisin B1 Despite Increasing Accumulation of Free Sphingoid Bases
Quanren He, Jiyoung Kim, and Raghubir P. Sharma,1 Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602-7389 This study showed that silymarin prevented FB1-induced liver injury and the overexpressions of selected genes for TNF-superfamily and IFNg.FB1 increased free sphingoid bases in tissues via the inhibition of ceramide synthase (Merrill et al., 1993; Wang et al., 1991). Free sphingoid bases could mediate cell death following FB1 treatment (Schmelz et al., 339 SILYMARIN PROTECTS AGAINST FUMONISIN HEPATOTOXICITY TABLE 2 Activity of Serine Palmitoyltransferase (SPT) in Liver and Kidney of Mice Following FB1 Exposurea Treatment Hepatic SPT activity Renal SPT activity Control 186.2 6 21.4 325.4 63.5 FB1 267.5 24.6* 319.5 14.8 Silymarin 80.0 12.9*,# 220.3 19.4*,# Silymarin 1 FB1 71.0 15.6*,# 251.1 13.6 aActivity of SPT is expressed as pmol product/min. mg protein. Data are presented as mean SE. *p 5 0.05 compared to control; # p 5 0.05 compared to FB1 treatment. 1998; Tolleson et al., 1999). In contrast to its inhibitory effects on liver damage and selected gene induction, silymarin dramatically increased FB1-induced accumulation of free sphingoid bases. The FB1-induced alterations in mouse liver were similar to those reported previously employing similar protocols (Sharma et al., 1997, 2003a,b). The only difference in treatments was the duration (3 vs. 5 days in former reports) and gender (females in the current experiments). Exposure of mice to FB1 caused the appearance of apoptotic cells in liver with no other noticeable alterations. The PCNA-positive cells were also increased in FB1treated mice. In conclusion, we have clearly demonstrated that silymarin plays a protective role in FB1 hepatotoxicity in a mouse Model. These findings suggest a therapeutic potential of silymarin in fumonisin liver injury in humans or animals exposed to fumo-nisin-producing, fungus-contaminated feeds. The efficacy of silymarin in the protection from liver damage after long-term exposure to the mycotoxin still needs to be studied.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=92) Niacin and Cholesterol -- abstracts states blocks cholesterol absorption ...
Date:
May 21, 2005 11:20 AM
The Era of Statins - Is There Still a Place for Other Classes of Lipid-Lowering Drugs? Wascher, Thomas C. Department of Internal Medicine, Diabetes and Metabolism Unit, and Diabetic Angiopathy Research Group, Medical University of Graz, Graz, Austria. HeartDrug (2005), 5(1), 34-38. CODEN: HEARCO ISSN: 1422-9528. Journal; General Review written in English. CAN 142:384798 AN 2005:64730 CAPLUS Abstract A review. Plenty of evidence suggests statins as the first-line therapy for the treatment of lipid disorders. However, further therapeutic options available in the treatment of lipid disorders are fibrates, niacin and cholesterol absorption inhibitors. In the present study, current treatment modalities of lipid disorders are reviewed, and their use was scrutinized based on the available evidence.
Niacin and cholesterol: role in cardiovascular disease (review). Ganji, Shobha H.; Kamanna, Vaijinath S.; Kashyap, Moti L. Atherosclerosis Research Center, Department of Veterans Affairs Healthcare System, Long Beach, CA, USA. Journal of Nutritional Biochemistry (2003), 14(6), 298-305. CODEN: JNBIEL ISSN: 0955-2863. Journal; General Review written in English. CAN 139:291534 AN 2003:542279 CAPLUS Abstract A review. Niacin has been widely used as a pharmacol. agent to regulate abnormalities in blood plasma lipid and lipoprotein metab. and in the treatment of atherosclerotic cardiovascular disease. Although the use of niacin in the treatment of dyslipidemia has been reported as early as 1955, only recent studies have examd. the cellular and mol. mechanism of action of niacin on lipid and lipoprotein metab. The beneficial effects of niacin in decreasing triglyceride and apolipoprotein-B contg. lipoprotein (VLDL and LDL) levels are mainly due to decreased fatty acid mobilization from adipose tissue triglyceride stores and inhibition of hepatocyte diacylglycerol acyltransferase and triglyceride synthesis, leading to increased intracellular apolipoprotein-B degrdn. and subsequent decreased secretion of VLDL and LDL particles. The mechanism of action of niacin to raise HDL levels involves decreasing the fractional catabolic rate of HDL-apolipoprotein A-I without affecting its biosynthetic rates. Niacin selectively increases blood plasma levels of Lp-AI (HDL subfraction without apolipoprotein A-II), a cardioprotective subfraction of HDL in patients with low HDL levels. Using human hepatocytes (Hep G2 cells) as an in vitro Model, recent studies indicate that niacin selectively inhibits the uptake/removal of HDL-apolipoprotein A-I (but not HDL-cholesterol ester) by hepatocytes, thereby increasing the capacity of retained HDL-apolipoprotein A-I to augment cholesterol efflux through reverse cholesterol transport pathway. The data provide evidence extending the role of niacin as a lipid-lowering drug beyond its dietary role as a vitamin.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=89) KudZu, Treatment of alcohol dependence or alcohol abuse
Date:
May 19, 2005 09:29 AM
For millennia, folk medicines have been used to treat ‘‘alcohol addiction’’ in China. A thorough literature search of the ancient Chinese pharmacopoeias revealed a long list of traditional remedies, including the 16 ‘‘stop-drinking’’ formulae of Sun Simiao (ca. 600 AD) and the ‘‘anti-alcohol addiction’’ formula of Li Dongyuan (ca. 1200 AD), 2 of the most reputed ‘‘medical doctors’’ in the history of Traditional Chinese Medicine. However, like those discovered by the ancient Romans,11 most of the ancient Chinese remedies for ‘‘alcohol addiction’’ were based on psychological aversion: to deter patients from further drinking by associating alcohol drinking with an unpleasant experience. Interestingly, as time went by, treatments based solely on psychological aversion were gradually eliminated from the ancient Chinese pharmacopoeias, presumably because of their ineffectiveness and/or undesirable side effects. The only remedies that have survived this historical trial-anderror scrutiny are those consisting the root (Radix puerariae, RP) or flower (Flos puerariae, FP) of Pueraria lobata (a medicinal plant known to the West as kudzu). It was on the basis of this historical backdrop, we initiated the search of safe and efficacious anti-dipsotropic (alcohol intake suppressive) agents from RP. This approach has led to the discovery of daidzin,12 an isoflavone that has since been shown to reduce alcohol drinking in all alcohol preferring animal Models tested to date.
Alcohol abuseAlcohol abuse and alcohol dependence (i.e., alcoholism) are serious public health problems of modern society. In the United States alone, an estimated 13 million adults exhibit symptoms of alcohol dependence due to excessive alcohol intake, and an additional 7 million abuse alcohol without showing symptoms of dependence according to U.S. Government projections from studies conducted in the mid-1980s. Alcohol dependence and abuse are very expensive: in economic and medical terms, it will cost the U.S. well over $200 billion in 1991 with no prospect of falling or leveling off. The social and psychological damages inflicted on individuals as a consequence of alcohol abuse, e.g., children born with fetal alcohol syndrome (FAS) and victims of alcohol-related accidental death, homicide, suicide, etc., are immense. While it is generally accepted that alcoholism and alcohol abuse are afflictions with staggering international economic, social, medical, and psychological repercussions, success in preventing or otherwise ameliorating the consequences of these problems has been an elusive goal. Only very recently the public view that alcoholism and alcohol abuse are remediable solely by moral imperatives has been changed to include an awareness of alcoholism and alcohol abuse as physiological aberrations whose etiology may be understood and for which therapy may be found through scientific pursuits. Both alcohol abuse and dependence arise as a result of different, complex, and as yet incompletely understood processes. At present, alcohol research is in the mainstream of scientific efforts. Our studies on alcohol (ethanol or ethyl alcohol) have been based on the hypothesis that its abuse can ultimately be understood and dealt with at the molecular level. Such a molecular understanding, if achieved, would provide a basis for the identification and development of appropriate therapeutic agents. Our view hypothesizes that the clinical manifestations of alcoholism and alcohol abuse are the consequence of aberrations or defects within one or more metabolic pathways, affected by the presence of ethyl alcohol. In order to test this hypothesis, our initial studies focused on physical, chemical, and enzymatic properties of human alcohol dehydrogenase (ADH), the enzyme that catalyzes alcohol oxidation according to the following reaction formula: CH.sub.3 CH.sub.2 OH+NAD.sup.+ .fwdarw.CH.sub.3 CHO+NADH In addition, our studies more recently have focused on the aldehyde dehydrogenases (ALDH) which catalyze the subsequent step in the major pathway of ethanol metabolism according to the following reaction formula: CH.sub.3 CHO+NAD.sup.+ .fwdarw.CH.sub.3 COOH+NADH Prior to our research (for example, see Blair and Vallee, 1966, Biochemistry 5:2026-2034), ADH in man was thought to exist in but one or two forms, primarily in the liver, where it was considered the exclusive enzyme for the metabolism of ethanol. Currently, four different classes of ADH encompassing over twenty ADH isozymes have been identified and isolated from human tissues. There is no reason to believe that all of these ADH isozymes are necessary to catalyze the metabolism of a single molecule, ethanol, even though all of them can interact with it. We have proposed that the normal function of these isozymes is to metabolize other types of alcohols that participate in critical, physiologically important processes, and that ethanol interferes with their function (Vallee, 1966, Therapeutic Notes 14:71-74). Further, we predicted that individual differences in alcohol tolerance might well be based on both qualitative and quantitative differences in isozyme endowment (Vallee, 1966, supra).
Our research has established the structures, properties, tissue distribution, and developmental changes for most of the ADH isozymes, which while structurally quite similar, and presumed to have evolved from a common precursor, are functionally remarkably varied. Of the more than 120 publications from our laboratory that relate to the above subjects, the following, arranged in six categories, are especially useful for instruction in the prior art.
Kudzu Recovery 60ctKudzu Recovery 120ct
Kudzu Root Extract 50capsKudzu Root Extract from Solaray 60ct
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=79) Immunomodulating and anti-tumor action of extracts of several mushrooms
Date:
May 18, 2005 10:11 AM
Quote from Abstract: The outcomes obtained in the experiments in vitro have predetermined check of these extracts on antitumor effect in experiment in vivo.As a Model of tumor growth, one of the most malignant tumors melanoma B16 was selected. AHCC with proper diet and nutrition could help reduce tumor size and/or reverse cancer in humans as shown in lab animal examples.
AHCC Complex 30 ct from Source NaturalsAHCC Complex 60 ct from Source NaturalsAHCC Complex with Bioperine for absorption 60ct from Source NaturalsAHCC Complex with Bioperine for absorption 30ct from Source NaturalsAHCC Plus 30ct from Source NaturalsAHCC Plus 60ct from Source Naturals
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=71) Effects of a novel formulation of essential oils on glucose–insulinmetabolism in diabetic
Date:
May 18, 2005 09:20 AM
Background: Insulin resistance and its most severe form type 2 diabetes mellitus are rapidly increasing throughout the world. It is generally recognized that natural products with a long history of safety can increase insulin sensitivity. Aims: The present investigation examined the ability of various combinations of essential oils such as fenugreek, cinnamon, cumin, oregano, etc. to enhance insulin sensitivity. As a first approximation, we examined the effects of these natural products on Zucker fatty rats (ZFRs), a Model of obesity and insulin resistance, and spontaneously hypertensive rats (SHRs), a Model of genetic hypertension. Material and Methods: Water or essential oils were given orally via droplets, and insulin sensitivity was estimated by systolic blood pressure (SBP) changes and circulating glucose and/or insulin concentrations. Results: We have found that the ability to alter SBP in rat Models is the most sensitive early index of insulin sensitivity. The combined essential oils lowered circulating glucose levels and SBP in both ZFRs and SHRs, suggesting that these natural products are enhancing insulin sensitivity. The second series of studies examined two additional combinations of essential oils along with the original formula. The major differences were in the types and proportions of individual oils contributing to a given formula. Conclusions: Although all the three formulae decreased SBP in ZFRs, one of the formulae was more effective than the others in lowering circulating glucose in the glucose tolerance testing. Accordingly, some essential oils may be added to the long list of natural products that can affect insulin sensitivity. Keywords: diabetes mellitus, essential oils, insulin resistance, insulin sensitivity, insulin sensitivity, natural products Received 11 August 2003; returned for revision 25 September 2003; revised version accepted 16 March 2004 Introduction The prevalence of insulin resistance and its most severe form type 2 diabetes mellitus is rapidly increasing in the USA – even throughout the world [1–3]. The recent increase is attributed, at least to some extent, to the greater occurrence of overweight and obesity that is due mainly to an augmented intake of calories and refined carbohydrates, lesser consumption of fibres and a more sedentary lifestyle [4–6]. Obviously, reversal of these situations should ameliorate the problem. Unfortunately, more is often needed than simply advising lifestyle changes that frequently fail in order to combat insulin resistance and its accompanying perturbations (cardiovascular diseases, obesity, dyslipidemias, diabetes mellitus and premature ageing) [7,8]. Experience shows that the afflicted not infrequently require aids to help with the maintenance of a healthful lifestyle. Correspondence: Harry G. Preuss, D, Georgetown University Medical Center, Department of Physiology and Biophysics, Basic Science Building, Room 231B, 4000 Reservoir Road, N.W., Washington, DC 20057, USA. O R I G I N A L ART I C L E doi: 10.1111/j.1463–1326.2004.00386.x # 2004 Blackwell Publishing Ltd Diabetes, Obesity and Metabolism, 7, 2005, 193–199 193
Cinnamon Extract and Blood sugar 60ctCinnamon Extract and Blood Sugar 120ct
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=68) Bee Propolis may limit production of DHT...
Date:
May 17, 2005 05:00 PM
Chrysin controls aromatase activity, and thus the production of estradiol and estrone, and provides an alternative embodiment of this invention. This embodiment may further comprise a substance that controls 5-alpha-reductase and its production of DHT. Other aromatase inhibitors include substituted androstenediones. There is also evidence that aromatase is involved in the production of DHT, which is well known for its negative effects on the prostate and male pattern baldness. An in vitro rat testis cell suspension Model was used to investigate the metabolism of tritiated testosterone, dihydrotestosterone, and androstenedione. In the presence of aromatase inhibitors and androstenedione, the metabolism was shifted towards 17-keto forms. This suggests that androstenedione and the derived aromatase inhibitors activate the 17 .beta.-hydroxysteroid-dehydrogenase in a product-activating manner. Thus, aromatase inhibitors may regulate the intratissular levels, not only of estrogens, but also of other hormonally active steroids like DHT and 5-androstenedione. Schroder et al., 31(4B) J. STEROID BIOCHEM. 685-90 (1988). Because of the usefulness of inhibiting aromatase in breast cancer patients, several synthetic aromatase inhibitors have been developed. See, e.g., U.S. Pat. No. 4,954,446. There are natural substances, however, such as chrysin, that have similar activity. Chrysin is a bioflavonoid found in propolis (bee pollen) and honey that has been demonstrated to be as potent and effective in inhibiting aromatase as the popular pharmaceutical, aminoglutethimide (AG). In aromatase enzyme assays, chrysin, 7,8 benzo-flavone (ANG), AG, flavone and genistein 4'-methyl ether (5,7-dihydroxy-4'-methoxyisoflavone, Biochanin A) were shown to inhibit aromatase. Chrysin and AG inhibited the enzyme by 50% at a concentration of 4.6 .mu.M and 7.4 .mu.M, respectfully, and only ANG had a high I.sub.50 of 0.5 .mu.M. Both Flavone and Biochanin A inhibited aromatase, but to a lesser degree. Campbell et al., 46(3) J. STEROID BIOCHEM. MOL. BIO. 381-88 (1993). In screening for potential chemopreventives against cancer, chrysin was one of the three of flavonoids with the greatest aromatase-inhibiting activity, with an inhibitory concentration (IC) of 1.1 .mu.g/mL. Jeong et al., 22(3) ARCHIVES PHARMA. RES. 309-12 (1999).
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Date:
May 09, 2005 06:10 PM
It's in the BloodNatural alternatives abound for managing cholesterol levels, backed by a growing body of research ©VR By Paul BubnyThe National Cholesterol Education Program (NCEP) last July lowered the threshold for considering the use of statin drugs—a move which some say was motivated more by profits than scientific evidence. For example, the Center for Science in the Public Interest pointed out that eight of the nine authors behind the new recommendations had financial ties to statin manufacturers, which stand to reap billions of dollars more from a category that grossed $14 billion in the U.S. last year. And though the Food and Drug Administration (FDA) in January decided against authorizing over-the-counter (OTC) sales of statin drugs, drug companies would still like to see this happen. “The medical establishment’s pushing of these drugs to becoming the number one category of prescribed drugs in the world has led them to keep lowering the total cholesterol number that triggers the drug recommendation,” said Neil E. Levin, C.C.N., D.A.N.L.A., nutrition educator, product formulator, and “Truth Advocate” for NOW Foods (Bloomingdale, IL), which produces a number of supplements for addressing cholesterol. “This is despite the lack of evidence that total cholesterol means much as regards cardiovascular risks. “Other tests are much more important in terms of predicting risks, including CRP (C-reactive protein), the balance of different cholesterol fractions, and homocysteine,” he continued. “Add adult-onset diabetes to the risk factors for cardiovascular disease (CVD).” At the same time, the allegation that enormous sales potential lay behind the lower threshold for prescribing statin drugs illustrates how widespread the problem of hypercholesterolemia (elevated total cholesterol) is. More than 100 million Americans have elevated cholesterol (total cholesterol values of 200 mg/dl and higher), and of these, more than a third have high cholesterol (levels of 240 mg/dl and higher), according to the American Heart Association. Those numbers have unfavorable implications for the incidence of CVD, as high cholesterol is considered a risk factor for coronary heart disease and stroke. While statin drugs haven’t garnered the same degree of negative publicity that COX-2 inhibitors have suffered lately, safety concerns have arisen nonetheless. For one thing, these drugs lower the liver’s production of coenzyme Q10 (coQ10) along with its production of cholesterol. “CoQ10 is related to energy production and immune functions, is an antioxidant, and [is] an important cardiovascular nutrient,” Levin said. “It is not good to lower one’s coQ10 levels by half!” Moreover, said Levin, statins increase the tendency of muscle tissues to break down. “Combined with inactivity or certain drugs, this can stimulate muscle wasting,” he said. “Muscle is where a good deal of calories are burned, so a loss of muscle could affect mobility and energy production, potentially adding to obesity problems. These muscle changes occurred in patients and persisted for years after treatment was discontinued, as shown by muscle biopsies, even if no obvious muscle problems were observed by the patients.” And the last word on the subject may not have been spoken. Predicted Dr. Frank King, Jr. president of King Bio Natural Medicine (Asheville, NC), “Once the appropriate studies are finished, these drugs, along with hypertensives, will hit the fan bigger than the COX-2 inhibitors.” Also looking toward the future, Levin said that of the 20 million Americans who will be “targeted” for statin drug prescriptions under the new NCEP guidelines, “Some of these will want to try natural methods first. Others will rebel at the side effects of the drugs and experiment with alternative products.” King and Levin both saw opportunity for natural products in the fallout from drug safety concerns, with King projecting that sales of his company’s cholesterol-related homeopathic remedies will double in 2005. “The reports of deaths from drugs will always overshadow the trumped-up studies and news reports blasting dietary supplements,” said Levin. “Vioxx knocked vitamin E off the media’s radar screens pretty rapidly, though we still see ignorant reporters citing that [Johns Hopkins] vitamin E analysis as if it were true. But the comparable safety of supplements means that open-minded people will want to at least try natural therapies before signing in to a lifetime of drug therapies. Meanwhile, the studies on natural products will continue to build our credibility.” Those studies keep coming in, with at least four major findings published in the past few months, plus a heart-health claim on walnuts authorized by FDA. They join a raft of earlier findings that link natural products—branded and otherwise—to healthy cholesterol levels.
"Blur of Products"With so many natural alternatives to cholesterol drugs available, it can be hard to keep track. “As with any other category, the blur of products as they cascade over several shelves means that the retailer needs to have a good sense of what works and what they want to recommend to their customers,” Levin said. “Really, each person needs a protocol that would include antioxidants, fiber, vitamins, herbs, and oils. The pre-mixed cholesterol support formulas are a good starting place.” To help retailers get a sense of “what works,” here is an alphabetical discussion of several nutrients that have demonstrated benefits in serum cholesterol levels. They include the following: Barley may help lower cholesterol, according to a report in the American Journal of Clinical Nutrition (2004, vol.80, no.5: 1185-1193). Twenty-five adults with mild hypercholesterolemia consumed a controlled diet low in total fat, saturated fat, and cholesterol for 19 weeks. They then added whole-grain products containing barley to their diets that contained low (0 g), medium (3 g), or high (6 g) amount of beta-glucan per day for five weeks. Total cholesterol was reduced by 4 percent 9 percent, and 10 percent, respectively. The diet with the highest amount of beta-glucan led to a decrease in LDL cholesterol of 17 percent. Chromium. There’s evidence, Levin said, that chromium in doses of 500 mg a day may decrease levels of low-density lipoprotein (LDL, the so-called “bad” cholesterol) and total cholesterol while raising levels of high-density lipoprotein (HDL, or “good” cholesterol). At the annual meeting of the American College of Nutrition last October, a poster presentation on the safety of Benicia, CA-based InterHealth Nutraceuticals’ ChromeMate niacin-bound chromium won first prize; among other things, the presentation cited chromium’s role in maintaining healthy blood lipid levels. Fatty Acids. The latest in a long line of studies demonstrating the benefits of fatty acids in heart health is a study published in The International Journal of Clinical Pharmacology and Therapeutics in December 2004. It showed that docosahexaenoic acid (DHA), an omega-3 fatty acid, can restore normal blood vessel function in children with inherited high cholesterol. The study, which used Martek DHA produced from microalgae, concluded that restoration of normal blood vessel function has the “potential for preventing the progression of early coronary heart disease in high-risk children.” “The evidence continues to accumulate on the cardiovascular benefits of DHA for people of all ages,” said Henry “Pete” Linsert, Jr., chairman and CEO of Martek Biosciences, an ingredient supplier based in Columbia, MD. “This study clearly indicates that DHA played an important role in healthy blood vessel function in the children in this study.” On the Omega-Research.com Website maintained by fish oil manufacturer Nordic Naturals (Watsonville, CA) can be found summaries of several earlier studies linking omega-3 fatty acids to maintaining healthy blood lipid levels, as well as related benefits such as elasticity of the arteries. In a 2003 study published in the American Journal of Clinical Nutrition, it was found that women receiving a mixture of 4 g eicosapentaenoic acid (EPA) and DHA along with 2 g of gamma-linolenic acid (GLA) had lower levels of LDL cholesterol after 28 days compared to those who received either the EPA/DHA supplements without DHA, EPA/DHA with a smaller dose of GLA, or GLA alone. Flax is another source of omega-3s, and Arkopharma/Health From The Sun (Bedford, MA) offers FiProFLAX in a variety of forms. Marketing director Hugues P. Mas said the flax is “QAI [Quality Assurance International] certified organic and guaranteed GMO [genetically modified organism]-free.” On its Website, the company offers a cholesterol quiz geared to consumers, discussing the importance of omega-3s as well as other nutrients. Garlic. Adding to an already considerable body of research demonstrating that garlic can lower total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol, researchers at UCLA in 2003 reported that Kyolic aged garlic extract reduced or inhibited plaque formation in the arteries of 19 cardiac patients taking statin drugs. Lead researcher Matthew Budoff, Ph.D. commented at the time that the study “suggests that aged garlic extract may be a useful and beneficial dietary addition for the people who have high cardiovascular risk or who have undergone heart surgery.” Budoff has since presented several trade show seminars sponsored by Los Angeles-based Wakunaga of America, the makers of Kyolic. Guggul. In use for centuries as a component of Ayurvedic medicine, guggul—a gummy resin tapped from the Commiphora mukul tree, which is native to India—has been studied since the early 1960s for its hypolidemic (blood-lipid lowering) properties. Sabinsa Corp. (Piscataway, NJ), an ingredient supplier which produces a standardized extract under the brand name Gugulipid, says the studies on guggul indicate that its hypolipidemic activity can be attributed to more than one mechanism of action. Among the possible mechanisms are: inhibition of cholesterol biosynthesis, enhancing the rate of excretion of cholesterol, promoting rapid degradation of cholesterol, thyroid stimulation, alteration of biogenic amines, and “high affinity binding and anion exchange.” Homeopathy. “Homeopathy activates the body’s own control system to work properly,” said King. “This is the safest and most curative approach to take. “Forcing the body into biochemical change even naturally doesn’t actually have the curative action of homeopathy,” King continued. “Homeopathy can even correct the genetic predispositions to disease we may have inherited from as deep as a thousand years into our family chain.” King Bio makes Artery/Cholesterol/BP, a homeopathic formula intended to help tone heart muscles and blood vessels. Low glycemic index foods. In a study published in the February issue of the American Journal of Clinical Nutrition, researchers found that high glycemic load is negatively correlated to serum levels of HDL cholesterol. Assessing the relationship between blood levels of lipids and diet in a test population of 32 healthy males and females ages 11 to 25, the researchers found that glycemic load accounted for 21.1 percent of the variation in HDL cholesterol. They concluded that glycemic load appears to be an important independent predictor of HDL cholesterol in youth and noted that dietary restrictions without attention to glycemic load could unfavorably influence blood lipids. Medicinal Mushrooms. Although its product SX-Fraction is intended primarily to address high blood sugar, Maitake Products, Inc. (MPI, Ridgefield Park, NJ) found in a clinical study that LDL cholesterol in diabetic patients declined modestly (from 142 mg/dl to 133 mg/dl) over a two-month period. Those taking SX-Fraction also lost about 7 lbs. in the same time period. “The more impressive lowering of cholesterol, however, comes from the dietary fiber that is found in all medicinal mushrooms,” said Ellen Shnidman, manager of scientific affairs at MPI. She cited animal studies which documented the cholesterol-lowering properties of four different mushrooms: maitake, shiitake, agaricus, and enokitake. For example, a study reported in the September 1996 issue of Alternative Therapies showed “a 44 percent reduction in total cholesterol in rats consuming maitake mushroom in their diet,” said Shnidman. “This cholesterol reduction is accompanied by weight loss, relative to rats eating a similar high-choelsterol diet without mushrooms. Apparently, cholesterol is excreted by the rats in sufficient quantity to aid in weight loss.” Oat bran. A 2004 consumer study conducted by the Natural Marketing Institute (NMI, Harleysville, PA) for Nurture, Inc. (Devon, PA), which produces the ingredient OatVantage, found that 63 percent of consumers managing their cholesterol levels prefer oat-based ingredients. Oat bran is the subject of a health claim authorized by FDA in 1999, and NMI research found that 69 percent of respondents preferred the FDA-permitted health claim, “Helps Lower Cholesterol,” over the Model structure-function claim, “Helps Maintain Healthy Cholesterol Levels.” “This is significant for food, beverage, and dietary supplement manufacturers who want to increase sales by using a more consumer-desired claim on the product label,” said Griff Parker, Nurture CEO. Plant sterols. Also the subject of an FDA-approved claim for heart health, plant sterols (structurally similar to cholesterol in humans) can block the absorption of cholesterol, according to a number of studies. In an “Ask the Doctor” publication (available online at www.atdonline.org), Decker Weiss, N.M.D. noted that sterols enter the same receptor sites that cholesterol enters on its way to the bloodstream. “The cholesterol, being blocked from absorption, remains in our intestines where it is eventually excreted,” Weiss wrote. General Mills has just introduced Yoplait Healthy Heart, a yogurt high in plant sterols. Policosanol. A mixture of fatty alcohols derived from sugar cane or beeswax, policosanol has been favorably compared in clinical studies to several types of prescription drugs for managing cholesterol. On its own, policosanol was found in a 1999 study to reduce LDL cholesterol while raising levels of HDL cholesterol. Probiotics. “Several studies have indicated that consumption of certain cultured dairy products resulted in reduction of serum cholesterol, as well as triglycerides,” wrote Dr. S.K. Dash, president of probiotic manufacturer UAS Laboratories (Eden Prairie, MN), in his Consumer Guide to Probiotics. Among other studies, Dash cited two controlled clinical studies from the VA Medical Center at the University of Kentucky. “In the first study, fermented milk containing [Lactobacillus] acidophilus was accompanied by a 2.4 percent reduction of serum cholesterol concentration,” he wrote. “In the second study, a different L. acidophilus strain reduced serum cholesterol concentration by 3.2 percent. Since every 1 percent reduction in serum cholesterol concentration is associated with an estimated 2 to 3 percent reduction in risk for coronary heart disease [CHD], regular intake of fermented milk containing an appropriate strain of L. acidophilus has the potential of reducing risk for [CHD] by 6 to 10 percent.” Dash said his company’s DDS Probiotics contain DDS-1 L. acidophilus, “which has been researched and demonstrated to show cholesterol-lowering effect.” Psyllium. “Internal cleansing is very important” in maintaining healthy cholesterol levels, “especially if you do it with a lot of fiber,” said Sunil Kohli, vice president of Chino, CA-based Health Plus, Inc. The cholesterol-managing ability of fiber in general and psyllium in particular is “very well-established,” he said. However, Kohli said, “It will probably do you no good if it’s random. It should be done on a regular basis, and it should be supervised. Consulting the doctor or pharmacist is important.” Soy. The protein in soy “has evidence of lowering total cholesterol and LDL cholesterol, based on reviews of studies using over 20 g of soy protein per day,” said Levin. “Soy isoflavones are considered only partly responsible for this effect.” Sytrinol. A patented proprietary formula derived from natural citrus and palm fruit extracts and containing citrus polymethoxylated flavones and palm tocotrienols, Sytrinol has been shown in clinical trials to improve total cholesterol, LDL cholesterol, and triglycerides by up to 30 percent, 27 percent, and 33 percent, respectively. Having just wrapped up Phase III of a long-term trial of Sytrinol, Chicago-based SourceOne Global Partners, which owns the exclusive worldwide license for intellectual property associated with the ingredient, is commencing a study that combines Sytrinol with plant sterols. Tocotrienols. On its Website discussing the science and benefits of tocotrienols (www.tocotrienol.org), ingredient supplier Carotech Inc. (Edison, NJ) identifies several benefits for blood lipid levels. Tocotrienols, according to the Website, have been shown to “inhibit cholesterol production in the liver, thereby lowering total blood cholesterol;” “[suppress] hepatic HMG-CoA reductase activity [and result in] the lowering of LDL cholesterol levels;” and “inhibit cholesterogenesis by suppressing HMG-CoA reductase.”
New WeaponsThere are also nutrients that are emerging as potential weapons in the fight against cholesterol. Levin cited rice bran oil, resveratrol, pantethine, l-carnitine, and niacin as showing promise. With all of this, Levin said, it’s important for retailers to remember that “they are not allowed to discuss diseases and remedies unless there is an approved FDA health claim allowed on the label, as with soy protein and plant sterols. What is allowed are structure-function claims such as ‘cholesterol support,’ ‘promoting normal, healthy circulation,’ ‘homocysteine regulators,’ etc.” Supplementation is only one tool for managing cholesterol levels, manufacturers pointed out. “Besides nutrition, lifestyle is a key to controlling cholesterol,” Levin said. “Eating a variety of antioxidant-rich foods will prevent the liver from churning out cholesterol as a ‘cheap’ antioxidant. The body uses oxidized cholesterol to patch leaky and damaged blood vessels, so the ability to build healthy collagen is a must, using nutrients like vitamin C, Pycnogenol, rutin, hyaluronic acid, and MSM. “Don’t forget exercise and stress reduction,” he added. “Stress results in high cortisol levels—usually accompanied by poor blood lipid levels—and a lack of good sleep to produce unhealthy people.” VR Vitamin Retailer Magazine, Inc., 431 Cranbury Road, East Brunswick, NJ 08816 //www.oprmagazine.com/
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Wintergreen (Gaultheria procumbens) is in the heather family of organic plants and is local to North America. It is a little evergreen herb that develops just something like 6 inches high with thin crawling stems. It has hanging white blossoms which are accompanied via red berries. Local Americans used to bite the stems to build respiratory limit. Early American pilgrims had their youngsters bite the leaves for some weeks each one spring to avoid tooth rot and throughout the American Revolution, it was a substitute for Black Tea. They so reveled in the essence that it has proceeded right up 'til today as the character of root brewskie, mulling over gum and toothpaste. The oil hails from steam refining of the leaves and produces an in number, entering fragrance. The science of wintergreen is very nearly indistinguishable to that of birch . 
What is bone loss?
