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Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?   
Date:
December 07, 2023 12:12 PM
Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body. While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption. GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age. The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels. In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body. This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form. But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them. So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing! Liver HealthWhen it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ. Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds. During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances? But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker! The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning. So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being! Alcohol IntoxicationAlcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells. To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes. The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group. The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver. Nonalcoholic fatty liver diseaseNonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels. Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy. In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management. Beautiful SkinBy activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions. Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores. Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects. Skin LighteningSkin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract. The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women. In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH. Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin. The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities. In summary, the administration of
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Date:
November 18, 2023 10:26 AM
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Date:
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Date:
June 15, 2023 02:12 PM
When it comes to maintaining optimal wellness, it's essential to prioritize your immune system and liver health. There are many supplements in the market that claim to boost your health, but Kal L-Glutathione holds a unique position in enhancing overall well-being. It is a powerful antioxidant that helps the body to fight toxins and protect against oxidative stress.
A Rich Antioxidant: L-Glutathione is a potent antioxidant that effectively fights free radicals in the body. These free radicals are unstable molecules that can cause DNA damage and contribute to the aging process. L-Glutathione's antioxidant properties help to neutralize free radicals and prevent oxidative stress, which is critical for maintaining good health.
Supports Liver Function: The liver is responsible for breaking down toxins and eliminating them from the body. L-Glutathione plays a crucial role in liver function by assisting in the detoxification process. It helps to eliminate harmful substances like alcohol, pollutants, and heavy metals, which can damage the liver and cause liver disease.
Enhances Immune System: Our immune system helps to fight off viruses and infections. L-Glutathione has been shown to promote healthy immune system response. It does so by stimulating the production of white blood cells, which are responsible for combating harmful bacteria and viruses.
Sustained-Release Capsule: KAL® L-Glutathione 500mg supplement comes in a Sustained-release capsule that slowly releases the supplement in the body. A Sustained release formula ensures that the supplement stays active for longer in the body. This slow-release mechanism ensures that the body can absorb the supplement in a gradual manner, thus maximizing effectiveness.
In Summary: L-Glutathione is a powerful antioxidant that provides several benefits to the body. It offers excellent support for liver function, enhances the immune system, and promotes overall wellness. Additionally, the Sustained-release capsule ensures that the supplement stays active for longer in the body, and the vegetarian capsule makes it suitable for those who follow a plant-based lifestyle. In summary, if you're looking for a supplement that can help you achieve optimal well-being, then KAL® L-Glutathione SR 500mg is the perfect supplement for you.
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Date:
January 08, 2019 08:13 AM
Oxidative neurodegeneration is a process in which oxidative stress results in degeneration of the brain, often related to a traumatic brain injury (TBI). Studies are now showing that curcumin has protective abilities that can help decrease the brain's vulnerability to further injury as a result of oxidative stress. This could be due to several factors such as its anti-inflammatory properties, the way it increases antioxidants, and its natural healing properties that can aid in regeneration. Key Takeaways: "When choosing a curcumin supplement, it is important to source one that is non-GMO, non-irradiated and preferably contains piperine (BioPerine) which enhances curcumin absorption by as much as 2,000 percent"
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Date:
March 20, 2017 04:44 AM
Researchers have discovered the benefits of walnuts in the area of reproduction and a number of other health issues. In their study there was a noticeable correlation between the type and quality of fat in relation to sperm health. The fats in walnuts corroborate a previous study that walnuts improve reproductive health. A higher ratio of Omega 3 to Omega 6 is an indicator in a study of fertile and infertile men. More researchers is needed as to benefits of Omega 3. The study has shown walnuts improve health in the following: prostrate cancer, breast cancer, cognitive function and type 2 diabetes. According to the British Journal of Nutrition walnuts are also good for sustained mental reasoning. Information from Natural Health, March 16, 2017 by Sade Oguntola. Key Takeaways: "A western-style diet has been blamed for lowering sperm function, especially motility, vitality and morphology in both humans and animals." Read more: http://tribuneonlineng.com/walnuts-can-help-improve-sperm-quality-scientists/
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Date:
January 09, 2017 12:59 PM
When it comes to sports nutrition, there are three very exciting developments that have taken place in sports nutrition right now. The first development is nitrates, which help you to perform better and longer. The second development is collagen, which helps with tendon and ligament integrity as well as reducing the risk of injury. The last one is casein protein which can allow for prolonged muscle building if taken before bed. Key Takeaways: "Once they make the switch, they say, not only are their race results and game-day performances better, they report Sustained energy, better moods, and clearer thinking." Reference:
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Date:
September 23, 2016 02:44 PM
A cup of coffee is a common thing that most of people drink in the morning. However, since many people realized that coconut oil and butter are healthy fats (Axe, 2016), they started replacing cream with them. This coconut and/or butter coffee is known as bulletproof coffee and it is a new trend of healthy morning drink. It has been extremely popular all over the world.
Coconut oil has so many benefits for your body, such as:
· Increases your energy - its ingredient, MCT (Medium Chain Triglycerides), is absorbed by the body and metabolized as fuel more quickly (Tifanny, 2016).
· Improves your immune system - There is a lot of lauric acid in coconut oil that is effective to prevent and cure many viruses (WebMD in Tifanny, 2016).
· Improves brain function – Its fatty acid plays an important role in memory and brain functions (Axe, 2016).
· Promotes heart health – Coconut oil contains good cholesterol that is good for your heart (Axe, 2016).
· Acts as anti-inflammatory – Antioxidant content makes coconut an effective anti-inflammatory food that help reduce arthritis (Axe, 2016).
· Is good for hair and skin – It is able to smoothen and tighten the skin, as well as maintain healthy hair (Axe, 2016).
On the other hand, butter also offers many advantages for your health, such as:
· Prevents and treats many diseases - Omega 3 fatty acids in butter are essential for growth, as well as prevention and treatment of arthritis, coronary artery disease, cancer, inflammation, and high blood pressure (Leonard, 2016).
· Improves your brain, blood circulation, and hormonal system – It helps prevent neurodegenerative and heart diseases, increase energy expenditure, and act as anti-inflammatory (NN, 2014).
· Is good for bones and blood circulation – Butter contains vitamin K that plays an important role in blood clotting and keeping the bones strong (Leonard, 2016).
· Helps with weight loss – It makes you feel full for a longer period and its conjugated linoleic acid (CLA) is an effective aid for losing weight (Leonard, 2016).
· Reduces caffeine sensitivity – Butter fat can protect the stomach from shakes and nausea caused by caffeine (Leonard, 2016).
· Boosts the energy – It provides more Sustained energy for the body (Leonard, 2016).
· Accelerates metabolism and digestion – Vitamin A, D, and E contained in butter are easily absorbed by the body and stored in gastrointestinal tract (Axe, 2016).
Based on the facts above, coconut and butter coffee is a healthy drink. However, excessive consumption of this bulletproof coffee is not good. Healthy fats can only function effectively in the body if the amounts taken are mooderate, not more and not less. Moreover, drink this coffee as the replacement of your breakfast is not recommended since it does not have enough essential nutrients (Gunnars, 2016).
References
https://authoritynutrition.com/3-reasons-why-bulletproof-coffee-is-a-bad-idea/
https://draxe.com/healthy-fats/
//nextshark.com/neil-degrasse-tyson-reveals-just-how-broke-you-are-compared-to-bill-gates/
//thecoconutmama.com/coconut-oil-coffee/
//www.naturallivingideas.com/add-butter-to-coffee/
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Date:
June 02, 2014 08:54 AM
What is a leucine What does leucine do L-leucine has direct bearing on the amount of insulin produced. L-leucine will stimulate the amount of insulin produced by the pancreas. One of the ways in which it influences the amount of insulin produced is by enhancing glutaminolysis by allosterically activating GDH (glutamate dehydrogenase). Benefits of leucine Increased insulin levels have a major implications on glucose metabolism. Increased insulin level will directly result into faster glucose absorption into the blood stream. Increased glucose metabolism prevents the body from using lean muscles to supply energy during workouts. Unlike isoleucine and valine, L-leucine are converted to glucose slowly and thus you can have Sustained energy for long. It is also very effective in muscle building. By stimulating insulin release and glucose metabolism, it enables key nutrients such as amino acids, Creatine and glucose to enter muscle cells. Since insulin will stimulate rapid muscle synthesis while inhibiting protein breakdown, L-leucine will build lean muscle mass with a short period. L-leucine is alternative to steroids, it is safer and its effects are lasting. During workouts, it supports oxidative metabolism in muscles and decrease protein degradation. If you are looking for the best way you can build muscle mass and strength without adverse effects, L-leucine is premier supplement. Apart from building muscle, l-leucine will also improve brain functions. You can take more workouts. L-leusine supplement has been used by many body builders and has been proved beyond doubt to be effective supplement. If you have been wondering if l-leucine help glucose metabolism and insulin function, no doubt it is can. You can also red more by visiting //www.livestrong.com/article/261185-what-are-the-functions-of-leucine/ //www.ncbi.nlm.nih.gov/pmc/articles/PMC2969169/
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Date:
May 08, 2014 08:48 PM
Magnesium is an important element that is essential for hundreds of biochemical reactions in the body. Its functions is to maintain normal nerve and muscle function, regulates blood glucose levels and aids the production of energy and protein, helps bones remain strong, supports a healthy immune system and lastly, keeps the heart beat steady. Cause of lack in magnesium Lack of magnesium causes many diseases. Substantial magnesium deficiencies have led to deaths caused by coronary diseases, diabetes, cancer and strokes. On the other hand mild magnesium deficiency causes nervousness, mental depression, increased sensitivity to noise, confusion, insomnia, twitching and trembling and apprehension. Sources of magnesium are from foods we eat Symptoms indicating lack of magnesium are: sleepiness, muscle weakness and hyperexcitablity. Magnesium works in the brain miraculously as remarked by many scientists through researches. Magnesium L-Threonate has the capability to cross into the brain and boost magnesium levels. Magnesium L-Threonate boosts magnesium levels in the brain in that, it maintains a state of healthy Sustained action. Through maintaining this healthy homeostasis, mental demands in the brain can respond well and perform cognitive responsibilities with less stress and fatigue. The blood-brain barrier is a diffusion barrier, which impedes influx of most compounds from blood to brain. It is composed of high-density cells that prevent passage of substances from the blood stream, but in a more action than the endothelial cells in the capillaries do in other parts of the body. Due the reasons, why most magnesium supplements do not cross blood barrier magnesium Threonte was introduced. Threonate is a vitamin C metabolite that acts as a carrier to help magnesium to penetrate into the brain. Sources
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Date:
April 24, 2014 02:58 AM
Do you know what Cacao and some of its health benefits are? What is a cacao Cacao is a kind of a tropical tree, which is part of the evergreen family that produces chocolate from its seeds in its raw state; that is before both sugar, and fats or some other forms of sweeteners are added to it. First, some of the benefits for finding the Cacao tree are that the cacao tree is grown under the shade of much bigger and different trees thus having a very profound effect on the Cacao seeds, which instead tends to be more potent and higher in antioxidants. The Cacao tree comes in different species that is Forastero, Trinitario and Caffeine. Cacao is used to describe both the seeds and the tree as well as the pods which holds the actual Cacao seeds/ beans which are also known as nibs. Well, the terms Cocoa and Cacao were often interchangeably used mistakenly to mean a similar thing. However, both the terms are used to differentiate different parts of the process and ingredients where Cocoa refers to the processed and sweetened Cacao. When the Cacao seeds without the shells are crushed and liquified into what is known as chocolate liquor, a dark chocolate is therefore created. Dark chocolate, which is synonymous with pure chocolate, exhibits a more powerful and a stronger effect of this health enhancing ingredients. The organic Cacao nibs’ offers a real chocolate treat as they are crunchy, flavorful and packed with powerful nutrients and antioxidants as well as natural mood lifters. Cacao in its raw form is regarded as the most potent and provides many benefits as it is packed with lots of nutrients such as vitamins and antioxidants, essential minerals, Phenylethylamine and many more. This therefore makes Cacao either to act as multivitamin or to be regarded as super food. Benefits of cacao Although the Cacao nibs produces chocolate which when taken in very large quantities may prove to be very dense in calories thus being unhealthy. However, when taken in moderation this product can be highly nutritious while providing numerous health benefits such as intestinal regularity, heart and blood vessels as well as blood Sustained sugar levels not to mention lowering of cholesterol, boosting cognitive performance, providing antidepressant benefits, elevating ones mood by boosting ones endorphin's. Cacao also contains poly phenols and more oxidants per cup which when taken offers the body a chance to fight cancer, aging, heart diseases. Additionally, some of the nutritional and health value that are offered by the Cacao arises from some of the beneficial ingredients such as Theobromine which is a mild stimulant to offer a diuretic effect hence helping to push toxins out of one's body. This helps to enhance one's mood. The Phenylethylamine on the other hand also acts to enhance a person’s mood making one to feel a sense of well being. Cacao increases the level of serotonin that one's brain produces which is a feel good hormone. Other essential minerals that are also found in Cacao include magnesium, Iron, zinc, copper, manganese, potassium while the essential vitamins that one will receive from Cacao are vitamin A,B1,2,3 and C,E as well as the Pantothenic acid. Sources
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Date:
April 24, 2014 02:58 AM
What is a cacao Cacao is a kind of a tropical tree, which is part of the evergreen family that produces chocolate from its seeds in its raw state; that is before both sugar, and fats or some other forms of sweeteners are added to it. First, some of the benefits for finding the Cacao tree are that the cacao tree is grown under the shade of much bigger and different trees thus having a very profound effect on the Cacao seeds, which instead tends to be more potent and higher in antioxidants. The Cacao tree comes in different species that is Forastero, Trinitario and Caffeine. Cacao is used to describe both the seeds and the tree as well as the pods which holds the actual Cacao seeds/ beans which are also known as nibs. Well, the terms Cocoa and Cacao were often interchangeably used mistakenly to mean a similar thing. However, both the terms are used to differentiate different parts of the process and ingredients where Cocoa refers to the processed and sweetened Cacao. When the Cacao seeds without the shells are crushed and liquified into what is known as chocolate liquor, a dark chocolate is therefore created. Dark chocolate, which is synonymous with pure chocolate, exhibits a more powerful and a stronger effect of this health enhancing ingredients. The organic Cacao nibs’ offers a real chocolate treat as they are crunchy, flavorful and packed with powerful nutrients and antioxidants as well as natural mood lifters. Cacao in its raw form is regarded as the most potent and provides many benefits as it is packed with lots of nutrients such as vitamins and antioxidants, essential minerals, Phenylethylamine and many more. This therefore makes Cacao either to act as multivitamin or to be regarded as super food. Benefits of cacao Although the Cacao nibs produces chocolate which when taken in very large quantities may prove to be very dense in calories thus being unhealthy. However, when taken in moderation this product can be highly nutritious while providing numerous health benefits such as intestinal regularity, heart and blood vessels as well as blood Sustained sugar levels not to mention lowering of cholesterol, boosting cognitive performance, providing antidepressant benefits, elevating ones mood by boosting ones endorphin's. Cacao also contains poly phenols and more oxidants per cup which when taken offers the body a chance to fight cancer, aging, heart diseases. Additionally, some of the nutritional and health value that are offered by the Cacao arises from some of the beneficial ingredients such as Theobromine which is a mild stimulant to offer a diuretic effect hence helping to push toxins out of one's body. This helps to enhance one's mood. The Phenylethylamine on the other hand also acts to enhance a person’s mood making one to feel a sense of well being. Cacao increases the level of serotonin that one's brain produces which is a feel good hormone. Other essential minerals that are also found in Cacao include magnesium, Iron, zinc, copper, manganese, potassium while the essential vitamins that one will receive from Cacao are vitamin A,B1,2,3 and C,E as well as the Pantothenic acid. Sources
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Date:
November 21, 2013 09:02 PM
What is Bee Pollen? Bee pollen is something that you need, as it will not give you a quick energy burst and crash as do many energy products that contain caffeine and ephinphedrine. Pollen is a natural supplement that you need to make sure you get Sustained energy you need. Bee Pollen is widely used as a energy boost because it is an all natural supplement that can allow individuals to get natural nutrition and energy from its use. This is a super thing about bee pollen. What are the Benefits of Bee Pollen It can give you Sustained energy and lots of vigor. It may even aid weight loss. that will help you to get the nutrition you need. Take advantage of this supplement and make sure to get the energy you need when you seek it. Bee pollen is absolutely natural and not synthetic.It is really very beneficial to find a supplement that is all natural and can give you the natural lift you seek. It is a all natural and a supplement that is not expensive to purchase. Bee pollen is often studied since the 1970's and athletes have used the energy from bee pollen. Bee pollen can help with the distribution and use of carbohydrates in the body. Athletes use bee pollen to boost their energy naturally and you can as well. Try this supplement as you can for Sustained energy. This is an affordable and well used supplement that can even supply vitamins to the body. References:
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Date:
January 24, 2013 01:29 PM
Energy Booster Guarana is used as an organic and effective energy booster. It has an identical chemical composition to that of caffeine, and also the plant seeds produce even greater caffeine effects than usual caffeine drinks. Guarana is released into the body much more slowly to provide longer stimulation. The plant immediately energizes the nervous system to provide Sustained energy and may be taken in small dose to fight weakness and improve activity levels. Additionally, it decreases tiredness, and improves mental alertness. Also, Guarana extract is taken by sports athletes to keep up their peak performance. Weight Loss Guarana is traditionally used for weight Loss as well. It helps reduce fluid retention, inhibits appetite and boosts metabolic process. As a result, the extra fat stored becomes a source of fuel to the body. Digestive properties Guarana also consists of tannins, which is valuable in treating diarrhea and other types of digestive problems. Aphrodisiac Because of higher content of caffeine, Guarana has received a reputation of a powerful stimulant and also aphrodisiac. When compared to other libido supplements, Guarana doesn't have any side effects. Pain relief As an all-natural adaptogen, Guarana can be used to boost the body's effectiveness against anxiety, stress and fatigue. It's traditionally been useful for migraines, menstruation pains as well as heart related illnesses.
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Date:
January 03, 2013 04:34 PM
Chromium is an important trace mineral for carbohydrates and fats processing by the human body. With the recent eating habits of refined foods, it's generally naturally deficient to many people. It's recommended to consume at least 50 micrograms of it each day. Similarly, the eating habits of today expose majority of people to diabetes. Chromium plays a major role in helping the body cells respond to insulin. In addition, a sufficient level of the mineral availability to the body leads to lower insulin necessity. On the other hand, its deficiency in the body has been associated with diabetes. It helps prevent diabetes by aiding insulin in glucose metabolism as well as preventing insulin resistance for victims already using insulin shots. It's generally low in the blood but it plays a major role of enhancing insulin efficiency thereby helps control blood sugar levels. Food Sources: You can get chromium from foods like broccoli, green beans, grape juice, potatoes, bananas, beef, orange juice and apples. There are also supplements that come in various forms and strengths. For instance, there are chromium picolinate, chromium chloride, chromium polynicotinate, chromium GTF and many others. These supplements differ in their absorption rates but have been proven in several studies to lower blood sugar as well as cholesterol. Some supplements are also safe to take alongside other medications. However, such a decision should always be taken with the consent of a medical doctor. Victims of type 2 diabetes have usually been found to have low levels of chromium in their bodies. Due to this reason, supplements have greatly assisted such individuals tackle diabetes. Similarly, women suffering from gestational diabetes have had their blood sugar levels drop after using chromium picolinate. The dosage to use varies but many doctors prescribe 1000 mcg every day for victims already suffering from diabetes. Vitamin C has been found to hinder the uptake of chromium. It's, therefore, essential to watch out what you are consuming if you will be taking the supplements. Sustained release chromium will help keep blood levels high with this important mineral and help one manage their blood sugar better.
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Date:
August 09, 2011 01:27 PM
Scientists have identified a diverse variety of bacteria and yeasts that work as microbes. Bacteria that manufacture lactic acid are the most commonly used probiotics in the food and drug industries. They comprise a large number of Gram positive and acid tolerant bacteria that are generally recognized as safe. Most of the species are utilized in the production of yogurt in addition to nutritional supplements.
Multi-strain probiotic supplements are deemed better, though most products contain only one strain of bacteria. Nonetheless, they all work on the same principle. Apart from the fact that they produce lactic acid, almost all strains available in the market possess the enzymes responsible for the synthesis of lactase. Hence, probiotics give special benefits to individuals suffering from lactose intolerance.
Lactobacillus is the genus of bacteria best known as probiotics. They are the most extensively studied of all microorganisms identified to be beneficial for human beings. It is an established fact that they provide a steady supply of nutrients. Their fermentation activity in the gut enables them to synthesize vitamin K and other organic compounds that promote healthy metabolism and lower blood lipid levels.
Some strains prevent constipation, diarrhea, indigestion, and many other disorders of the digestive tract. For one, probiotics are capable of digesting complex carbohydrates that usually pass the small intestines largely unchanged. These compounds are beneficial for blood sugar. The by-products add bulk to stool, speed up the passage of fecal matter in the colon, and promote regular bowel movement.
There are strains that release natural antibiotics called bacteriocin. These compounds either directly kill pathogenic microbes present in the gut or suppress protein synthesis necessary for their survival. By so doing, probiotics curtail population growth of harmful bacteria that are often incriminated in the disease activity of ulcerations in the alimentary canal and complications of inflammatory illnesses.
Due to the fact that each strain provides unique benefits to health, it is best to choose a probiotic supplement that contains several strains of friendly bacteria. It is also important to read on the total bacterial count the product promises to deliver. Medical professionals caution the supplementation of probiotics with very high amounts of bacteria as they may disrupt the natural pH in the digestive tract.
Probiotic supplements that require refrigeration are usually not shelf-stable, and thus its quality is likely to get compromised during shipment. There are products that use Sustained release technology and formulated to withstand the acidic environment of the stomach. Experts believe that releasing probiotics in the intestines helps as friendly bacteria take up residence in the gut.
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Date:
March 24, 2011 02:18 PM
Vinpocetine is a derivative of an organic compound found in the plant species Vinca minor, or common periwinkle. It is best known for its neuroprotective effects and used in Europe and Japan in treatment of age-related cognitive decline. More often than not, its activities inside the human body are described as vasodilator, which means it increases blood flow. It has also seen a growing presence in the North American market as a dietary supplement.
Vinpocetine is available as a prescription drug in certain European countries and Japan and has shown to be speed up prognosis of patients who suffered cerebrovascular accident, or CVA, which is commonly referred to as stroke. Most cases of cerebrovascular accident are brought on by ischemia, or very poor circulation of blood to certain parts of the brain. This is exactly what vinpocetine is beneficial for, and recommended dosages have so far yielded very encouraging results.
Improves Blood Circulation in the Brain
It has long been postulated that one of the mechanisms of action of vinpocetine is limiting the effects of Na+ channels that are sensitive to voltage. This creates a neuroprotective effect believed to contribute to mental clarity and Sustained attention. Striatal nerve endings produce extracellular Ca+ ions that induce neuronal damage through a phenomenon called excitotocity. High levels of Ca+ ions are now alleged to be correlated with voltage-sensitive Na+ channels. Striatal nerve endings see a decline in Ca+ ions when Na+ channels are influenced by vinpocetine, and in the process lessen excitotoxicity.
Attenuates Ischemic Neuronal Damage
In addition to limiting neuronal damage induced by excitotoxicity, which in turn results from cerebral ischemia, vinpocetine plays an active role in the upkeep of brain cells after being subjected to ischemic damage. As a vasodilator, it not only counters the effects of ischemia but also significantly increases the brain’s access to bioactive molecules like oxygen and other nutrients exclusively distributed by the circulatory system.
It also inhibits the enzyme phosphodiesterase, which is specialized for the breakdown of cyclic adenosine monophosphate, or cAMP, and cyclic guanosine monophosphate, or cGMP. By so doing, vinpocetine contributes to glucose metabolism and energy production in the brain, and at the same time, improves the distribution of bioactive compounds in the central nervous system.
Displays Neuroprotective Activities
Vinpocetine and its precursor belong to a group of indole alkaloids known as tryptomines, which are present in the human brain and the rest of the central nervous system in minute quantities. These organic compounds make up several psychoactive drugs and in the human body act as neuromodulators and neurotransmitters in the form of melatonin and serotonin.
Vinpocetine in particular displays activities that are primarily anti-inflammatory in nature. Several studies point to its effects on the enzyme complex called IkB kinase, which regulates cellular responses to inflammation, by preventing the translocation of a protein complex called responsible for the process of inflammation within cells.
In a Nutshell, vinpocetine can help you think clearer and protect the brain from inflammation and free radical damage. Give vinpocetine a try today!
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Date:
December 23, 2010 09:48 PM
Milk thistle also helps to reduce the cholesterol content of the blood and to improve the generation of glutathione, the body's master-antioxidant. Many studies have shown that milk thistle enables patients to survive longer after life-threatening liver conditions such as cirrhosis, and also protects it from the effects of Sustained use of common drugs such as acetaminophen (Tylenol and Paracetamol) that progressively damages liver cells, and also of many antipsychotics and antibiotics that have a similar effect.
There are no doubts that taking milk thistle does your liver a great deal of good and leaves it in a much healthier state than it found it.
Over the counter painkillers such as Tylenol and paracetamol are based upon a chemical known as acetominophen. Milk thistle can be used to reverse the damage that acetaminophen can cause to your liver if you catch it early enough. Here is how this form of painkiller can cause damage to your liver.
Acetaminophen undergoes processes known as sulfation and glucuronidation prior to being excreted from the body. This process is not harmful to the liver, and is a normal biochemical means of removing excess acetominophen from your body after it has done its work. However, if you have taken excess acetaminophen (>4g/day or 8x 500mg tablets) there is too much for the above process to handle, and a secondary biochemical route (the cytochrome p-450 system) is taken that generates an intermediate product known as NAPQI.
Normally, this NAPQI is safely metabolized by the antioxidant glutathione but if there is insufficient glutathione in your system then the NAPQI will destroy cells in your liver. That can occur if too much acetaminophen has been taken for the glutathione to handle, if alcohol is also involved or if the diet of the patient is nutritionally deficient. If left untreated this condition can be resolved only by a liver transplant, without which it is usually fatal. Milk thistle can help to repair this damage and survival is more likely with patients who take milk thistle than those that do not.
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Date:
April 17, 2009 11:20 AM
Malabsorption occurs when the body fails to properly absorb vitamins, minerals, and other nutrients from food. Even though a person’s diet is adequate, an individual with malabsorption develops various nutritional deficiencies. This problem is often the result of impaired digestion, impaired absorption of nutrients into the bloodstream from the digestive tract, or both.
Common symptoms of malabsorption syndrome include constipation or diarrhea, dry skin, fatigue, gas, mental difficulties such as depression or an inability to concentrate, muscle cramps and/or weakness, premenstrual syndrome, steatorrhea, a tendency to bruise easily, failure to grow normally, thinning hair, unexplained weight loss, and visual difficulties especially with night vision. Abdominal comfort may also be present and a combination of anemia, diarrhea, and weight loss is typical. However, in some individuals, obesity may result if fats are deposited in the tissues rather than being utilized properly by the body. Additionally, the body may begin to crave more and more food, which often leads to the consumption of many empty and/or fat calories.
Factors that can contribute to a malfunction of the absorption mechanism include digestive problems, poor diet, excess mucus covering the intestinal lining, an imbalance in intestinal bacterial flora, the use of certain medications, food allergies, and illnesses such as cancer and AIDS.
No matter how good your diet is or how many supplements you take, you will have nutritional deficiencies if you suffer from malabsorption syndrome. These deficiencies lead to other problems. The impaired absorption of protein can cause edema, while a lack of potassium can cause muscle weakness and cardiovascular problems. Anemia results for a lack of iron and folic acid, while bone loss and tetany can be caused by a lack of calcium and vitamin D. Bruising easily results from a lack of vitamin K, while night blindness comes from a deficiency of vitamin A. The failure to absorb B vitamins and to transfer amino acids across the intestinal lining interferes with the production of needed digestive enzymes and causes further malabsorption, as these nutrients are essential in the absorption process itself. This causes a vicious cycle to be produced.
Malabsorption is a factor in other medical and physical problems, along with being a serious condition in itself. The body needs all nutrients in balance because they have to be able to work together. If there is a deficiency in even a single nutrient, the body no longer functions as it should, allowing all things to go awry. This results in disease. Malabsorption is a common contributing factor to a wide range of disorders, including cancer, heart disease, osteoporosis, and all types of infection.
People with malabsorption syndrome must take in more nutrients than the average person to compensate, and to treat and correct the problem. It is best to bypass the intestinal tract as much as possible when supplying these nutrients. As a result, choosing supplements that are Sustained-release and large in size should be avoided. Many people with malabsorption problems can not break down supplements taken in hard pill form. Therefore, injections, powders, liquids, and lozenges provide nutrients in forms that are more easily assimilated.
The following nutrients are recommended for dealing with malabsorption syndrome: acidophilus, vitamin B complex, bioperine, calcium, free-form amino acid complex, garlic, magnesium, vitamin C with bioflavonoids, vitamin E, essential fatty acids, a multi-vitamin and mineral complex, proteolytic enzymes, and zinc lozenges. Additionally, the following herbs may be beneficial: alfalfa, dandelion root, fennel seed, ginger, nettle, aloe vera, peppermint, black pepper, buchu, goldenseal, irish moss, rhubarb, and yellow dock.
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Date:
April 13, 2009 03:51 PM
L-citrulline is an alpha-amino acid, first isolated from the watermelon in 1930: hence the name, citrullis being Latin for that fruit, the skin of which is rich in the substance. It is used to enhance performance in sports, particularly through aiding recovery after exercise, and also helps the liver to detoxify the blood.
It is not an essential amino acid in that it is produced by the body and need not be part of your diet. It is a precursor to arginine, which involves the Sustained release of nitric oxide in the endothelium that promotes increased flow of blood and the blood vessels as described further below. One of the biochemical pathways for its biosynthesis involves the urea cycle, whereby the toxic ammonia is detoxified into an easily excreted form through its conversion to urea.
The urea cycle consists of five reactions, and citrulline is formed in the second of these. In the first of these, ammonia reacts with bicarbonate to form carbamoyl phosphate, the phosphate coming from the two molecule of ATP used to energize the reaction. These are converted to adenosine diphosphate (ADP), and the carbamoyl phosphate then reacts with ornithine to form citrulline, which takes part in step three that eventually leads to the formation of urea.
The second way in which L-citrulline can be biosynthesized is from the oxidation of arginine, a natural amino acid. Arginine is oxidized into N-hydroxyarginine, and then into L-citrulline with the release of nitric oxide.
So that's how it is produced in the body, but how does it help sportsmen, and what part does it play in detoxification? Its effect on recovery after exercise is connected with blood flow. Energy is created in the mitochondria that are contained in every cell off the body. Among the raw materials needed for the production of energy are glucose and oxygen: glucose obtained from the carbohydrates in your diet, and oxygen transported by the hemoglobin or red blood cells.
Both of these rely on blood flow: greater the volume of blood transported to the cells then the greater the ability of these cells to produce energy. During periods of exercise, a good supply of blood is required to provide the raw materials needed for the energy demand of the muscles involved in the exercise. Not only that however, but recovery after exercise involves the replacement of electrolytes, the glycogen used in extensive aerobic and anaerobic exercise and protein replacement, particularly where catabolism has occurred.
In order to supply these raw materials at an adequate rate, it is necessary for the flow of blood to the appropriate muscles to be sufficient. A major restriction to increase blood flow is elasticity of the blood vessels and cells. Although a healthy heart is capable of providing the necessary quantities of blood, and hence of nutrients, any restriction to the flow could cause dangerously high blood pressure.
Nitric oxide plays a signaling role in enlarging blood vessels to allow an increased blood flow when it is needed by the body. It can provide more blood to the stomach during digestion and to the muscles during exercise and recovery.
During hard exercise, nitric oxide can act as a pump that provides blood during exercise and also during recovery. It can therefore provide more rapid gains in lean mass, increased endurance and faster muscle recovery. The way it does this is to send a signal to the smooth muscles to relax; smooth muscles such as those found in veins and arteries, so resulting in vasodilation therefore allowing increased blood flow.
It is the endothelium, the inner lining of blood vessels, which uses the nitric oxide to provide the relaxation signal to the smooth muscles surrounding it. In fact, it is the effect of nitric oxide that enables those living at high altitudes to develop increased stamina and speed over those at lower altitudes, and find more world records seem to be broken during athletics meetings, such as Olympic Games, held at high altitudes. This is because the production of nitric acid is increased at higher altitudes with slightly lower oxygen levels. This is the same effect that is used by vasodilators such as amyl nitrite and Viagra that work by increasing nitric oxide levels in the smooth muscle wall of the blood vessels.
It should not be surprising therefore, that L-citrulline should work in a similar way, since it is intimately involved in the production of nitric oxide. Although this is now generally understood, what part does supplemental citrulline play in the body if it is a non-essential amino acid?
Supplemental L-citrulline is useful in supporting the detoxification of ammonia in the liver when supplies of ornithine carbamoyl transferase is naturally in short supply. This is the enzyme that catalyzes the reaction between ornithine and carbamoyl phosphate to form citrulline. Supplements can then help in the removal of ammonia from the blood, and also provide material for the continued production of nitric oxide support muscular activity and its recovery after exercise.
Ammonia itself is a by-product of intensive exercise, and without the urea cycle the body would rapidly become polluted. It is a very toxic product, and causes the death of thousands of people each year. This is generally in people who suffer liver and kidney disease, and the ammonia can be broken down and excreted.
Your brain cells are particularly sensitive to ammonia, and as levels increase the effect progressively ranges from drowsiness thru tremors to coma and eventual death. Any condition, therefore, that reduces the body's capability of metabolizing ammonia is potentially very serious, and any supplement that can help prevent this is valuable.
L-citrulline is believed to help in such situations, although any condition affecting the efficiency of the kidneys or liver and that can cause toxicity due to ammonia or any other toxic substance, should be referred to your physician. It is for its effect in increasing blood flow to provide sufficient raw material, for both the energy needed for high levels of exercise and for muscle recovery, that citrulline is predominantly used as a supplement.
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Date:
February 16, 2009 01:18 PM
Glaucoma is a group of diseases that affect the optic nerve and can lead to irreversible vision loss. It is usually associated with elevated fluid pressure within the eye. All forms of glaucoma can cause damage to the optic nerve and lead to vision loss, even blindness, if left untreated. About 2.2 million Americans have been diagnosed with glaucoma and as many as 2 million more could have it and not yet know. It is one of the lading causes of blindness and is expected to become more prevalent in years to come due to the growing population of older adults.
Those people who are at greatest risk for developing glaucoma are people over the age of sixty, people of African ancestry, and people with diabetes, high blood pressure, severe myopia, or a family history of glaucoma. Smokers also have an elevated risk, as do those who have Sustained eye injuries or who have used steroids for an extended period of time.
About 3 percent of Americans are believed to have open-angle glaucoma, which is the most common form of this disease. Because this disorder causes no symptoms until it is quite advanced, only about half of those who have it are actually aware of it. In open-angle glaucoma, there is no physical blockage and the structure of the eye appear to be normal. However, the drainage of fluid is inadequate to keep the intraocular pressure at a normal level.
The most pronounced symptoms of open-angle glaucoma are the gradual loss or darkening of peripheral vision and a marked decrease in night vision or the ability of the eye to adjust to darkness. Other possible symptoms include chronic low-grade headaches, the need for frequent changes in eyeglass prescription, and/or seeing halos around electric lights.
A far less common, yet more serious, form of glaucoma is closed-angle glaucoma. Closed-angle glaucoma is much more dangerous than open-angle forms because it almost never manifests any symptoms until very late in the condition. By that time, vision may be irreversibly damaged.
Glaucoma probably has many causes, with many scientists believing it may be closely linked to stress and nutritional problems or disorders like diabetes and high blood pressure. Some think that excessive amounts of glutamic acid, which is a nonessential amino acid, may be involved. Glaucoma has also been linked to deficiency in nitric oxide, which is a molecule that is critical for healthy blood vessels. Problems with collagen, the most abundant protein in the human body, have been linked to glaucoma as well. Collagen increases the strength and elasticity of tissues in the body, especially those of the eye. Collagen and tissue abnormalities at the back of the eye contribute to the clogging of the tissues through which the intraocular fluid normally drains. This results in elevated inner eye pressure, leading to glaucoma and related vision loss.
The following nutrients are considered to be very important when dealing with and preventing glaucoma: choline, essential fatty acids, glutathione, rutin, vitamin A, vitamin B complex, vitamin C with bioflavonoids, vitamin E, alpha-lipoic acid, magnesium, a multivitamin and mineral complex, and zinc. Additionally, the following herbs are helpful: bilberry, chickweed, eyebright, coleus forskohli, fennel tea, chamomile, ginkgo biloba, zinc sulfate, jaborandi, and rose hips.
To resolve issues with the eyes, one must change their diet, exercise, and take supplements and herbs like what are listed above. Medical doctors are at a loss as to how glaucoma happens but they can help stop the progression of this disease if detected early on. Always consult your doctor before adding vitamins and herbs to your diet, vitamins and herbs are available at your local or internet health food store.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
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Date:
January 05, 2009 04:31 PM
L-Alanine is one of 20 amino acids that are used by the body to manufacture the proteins essential for life. Each protein possesses specific biological properties that are imparted by the sequence of amino acids it contains. Proteins control the chemistry that takes place within the cells of our body, and comprise all of the enzymes that catalyze the body's biochemistry.
Amino acids are also the building blocks of DNA that determines the genetic make-up of individuals, and that also provides recipes or templates for the production of proteins from amino acid sequences. There is a different DNA template for every protein required by the body that determines which of the 20 amino acids are needed, and in what order they are to be combined with one another to manufacture the desired protein.
10 of these 20 amino acids can be synthesized by your body's biochemistry, the other 10 being essential parts of your diet. If you fail to include just of these 10, then your body will break down its proteins until it has obtained a sufficient supply of that amino acids for its needs. That involves muscle and other tissue degradation, and is one of the symptoms of malnutrition. Amino acids are not stored, and a daily supply is essential to avoid these symptoms.
L-Alanine is one of the ten that the body can manufacture, and used by the body to help build protein and also to enable the body to make use of glucose to generate energy. It does so as part of what is known as the glucose-alanine cycle. During anaerobic exercise, such as in weightlifting and Sustained running, muscles produce lactate and also alanine.
The alanine is passed on to the liver where it is converted to energy via its conversion to glucose. This is not a particularly efficient means of creating energy because a byproduct of the process is urea, the removal of which in turn requires energy. However, it serves its purpose as an energy source once the liver is depleted of glycogen. In fact that is the major use to which alanine appears to be put by the body: the conversion of glucose to energy.
The way the glucose-alanine cycle works is that a process known as transamination produces glutamate from the amino groups of amino acids that are degraded during exercise. Glutamate is then converted to pyruvate by means of the enzyme alanine aminotransferase, with the production of alanine and alpha-ketoglutarate. This is a reversible reaction, and after the alanine has been carried by the bloodstream to the liver, the reaction reverses with the regeneration of pyruvate that undergoes gluconeogenesis (generation of glucose).
The result of this is glucose that returns to the muscle tissue to provide more energy. The glutamate is broken down to the ammonium ion in the mitochondria, which in turn enters the urea cycle with the production of urea.
In a nutshell, then, the glucose-alanine cycle removes glutamate and pyruvate from muscle tissue to the liver where glucose is generated from the pyruvate and returned to the muscle. Since gluconeogenesis involves the expenditure of energy, and this occurs in the liver rather than in the muscle, all the energy in the muscle can be used for muscle contraction.
L-Alanine possesses other properties, among them the ability to help maintain the health of the prostate. A study of benign prostatic hyperplasia (enlarged prostate) indicated that treatment with L-alanine, glutamic acid and glycine over a period of three months reduced the symptoms. However, make sure that you consult your physician before using alanine in this way. This is not because there are any known adverse side effects, because there are not, but because it I always wise to so with any supplement taken with a view to treating any medical condition.
A less obvious application derives from the fact that it forms a stable free radical when deaminated. Deamination can be initiated by radiation, and so the concentration of this free radical can be measured to ensure that the correct dose of radiation is being given in dosimetric radiotherapy. It is not always easy to control the dose accurately, and this property of alanine allows it to monitored and to ensure that it is neither too low to have the desired effect, nor dangerously high.
Although it is a non-essential amino acid, and can be produced by the body, a dietary supply or supplement is advantageous if extra energy is required. Good dietary sources of L-alanine include meats, seafood, eggs, nuts, beans, seeds, brewer's yeast, corn and legumes among others. Supplements are also available, and useful for body-builders, weightlifters and others involved in anaerobic exercise. Due to the glucose-alanine cycle, it can possibly provide energy when lactate build-up would otherwise lead to muscle cramps.
Those for whom a supplement could be useful are athletes and others who are trying to build muscle and stamina, or reduce their body fat and also the obese and overweight for the same reason. There is also evidence that a combination of the amino acids alanine, glycine and arginine can help to reduce arterial plaque from oxidized low density lipoproteins, and can also help to reduce high blood pressure.
Deficiencies are rare, although groups that do not eat meat should be careful to eat foods with a good alanine content. There are no known side effects of a deficiency since the body will generate what is needed for normal purposes, and while the supplement appears to have no side effects, it is advisable that pregnant and lactating women should first seek medical advice. The same applies if you suffer from hypertension or diabetes. High doses of alanine might also affect those with kidney or liver disease.
Although the benefits of supplementation of L-alanine might not be immediately obvious, the results and the science indicate that it is effective in making better use of blood glucose in that the adenosine triphosphate (ATP) created in the muscle tissue is allowed to be expended on muscle contraction while the glucose-alanine cycle provides the energy needed for gluconeogenesis.
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Date:
February 07, 2008 05:18 PM
The B vitamins comprise a range of water soluble vitamins that frequently work together to impart a number of general benefits to your body’s health. In general they support and maintain the metabolic rate, maintain the function of the nervous system, support the immune system, maintain healthy skin and muscles and help to promote cell growth and division. They work together to suppress the causes and symptoms of cardiovascular disease and stress and they are dispersed throughout the whole of the body by means of the circulation system of the blood.
In very general terms they collectively ensure that the body is provided with energy from the metabolism of carbohydrates and glucose. They are also needed for the metabolism of fats and proteins, and also the maintenance and health of the nervous system in general.
There are many natural sources, including lentils, potatoes, liver, turkey, brewer’s yeast, and also, of course, dietary supplements.
Vitamin B Complex can help to restore the adrenal glands from stress, but to understand how it does so, it is first necessary to understand what these glands are, and the part that they can play in stress.
The adrenal glands are situated just above each kidney, and take the form of two small pieces of tissue in the shape of a pyramid that generate specific hormones and chemical messengers. You have likely heard of adrenaline, the hormone that make you respond to certain types of stress either through flight or by fighting: what is known as the fight or flight reaction. Well, in fact there are two of them, noredrenaline being the other. They are also known as epinephrine and norepinephrine respectively.
Both the adrenal glands are controlled by what is known as the HPA axis, short for the hypothalamus-pituitary-adrenal axis which is the stress center of the body. The adrenals are the main steroid-producing plants in the body, responsible not only for the adrenaline hormones, but also for cortisone and hydrocortisone, testosterone, estrogen, cholesterol, progesterone and a number of others. These are produced in the outer cortex of the adrenal glands, whereas adrenaline and noradrenaline are produced and secreted by the medulla.
Adrenaline and cortisol are responsible along with others for the balance of your body fluids, blood sugar and blood pressure and many of the other main metabolic functions of the body, and if the adrenaline is not working properly, it can disrupt the metabolism of your blood glucose into energy, giving you a weak run-down and listless feeling. This is not surprising since your energy is failing at the cellular level.
The main reason for adrenal fatigue is stress. Either emotional or physical stress or even poor nutrition can be responsible for reducing the functioning of the glands to such an extent that they no longer provide the steroid hormones in the proper balanced quantities needed to maintain the proper functioning of your metabolic processes. Unlike Addison’s disease, which a complete stoppage of the functioning of the adrenal glands, in Adrenal Fatigue Syndrome the glands still function, but at a reduced capacity and the various products they are responsible for generating are secreted in reduced and imbalanced quantities.
However, fatigue is not normally the first reaction of the body to stress. As normal stress levels increase the bodies response is generally to secrete higher levels of adrenaline, and the cortex produces extra cortisol and other hormones. As stress continues beyond the intermittent stage and becomes more constant, the adrenals produce a more Sustained high level of hormones, that generally raise blood pressure and also increase the level of sugar in the blood in order allow a Sustained increase in energy levels. Corticosteroids are produced to maintain this higher level reaction to stress.
Finally, when the adrenals can sustain this high level of activity no longer, adrenal fatigue sets in which is when the worst symptoms of the stress are evident: exhaustion, both physically and mentally, excessive fear, guilt and worry, and under-activity of the HPA axis leads to depression, hopelessness and severe illness, often due to a weakened immune system.
So where does the B vitamin complex come into this? Vitamin B complex includes niacin, thiamine, pantothenic acid, riboflavin, and vitamins B6 and B12. As already stated, the complex is useful in supporting many of the critical functions of the body from healthy bones to healthy blood cells, and nervous systems. It also helps to maintain your reproductive system and can be used in cases of nerve-related conditions such as sciatica and neurological conditions.
Pantothenic acid, vitamin B5, is particularly useful in dealing with stress in that it enhances the activity of the adrenal glands. It also increases your energy levels due to its effect on the Krebs Cycle through its action as a precursor of acetyl Coenzyme A and acetylcholine which is a primary neurotransmitter. This helps to reduce fatigue and the pain of headaches caused by excessive stress and consequent reduction in adrenal output. Pantothenic acid is also essential during the metabolism of proteins, fats and carbohydrates, and is important in the maintenance of healthy nerves, skin and glands.
In fact the whole of the vitamin B family work together to make sure that your whole nervous system and metabolism remain healthy. People with high stress jobs often take the vitamin B complex to help reduce that stress and also anger. Excessive stress and anger can lead to anxiety and overwork the adrenal glands, and B complex can help to restore these to their normal function.
If you are concerned about your adrenal health, you can have a simple test carried out on your saliva, blood or urine by a trained medical practitioner. Many doctors do not know to carry out this test since it is not a normal test as would be used to detect Addison’s Disease, or complete adrenal failure, but only adrenal fatigue, so ask specifically for an adrenal fatigue check.
A quick self-test is to shine a light into an eye using a flashlight while looking in a mirror. They pupil should contract and return to normal after about 30 seconds. If it fails to do so, or even dilates, then that is a sign of adrenal fatigue. However, you must have it confirmed by a proper test.
All in all, a B complex supplement is a good way to restore adrenal glands from stress, and it also helps your nervous system in general, in addition to aiding the metabolic processes of your body. However, make sure that your symptoms are what you think they are by seeking professional medical advice.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1713)
Date:
December 24, 2007 02:11 PM
If you are a teenager a cure for acne will likely be first on your list after finding a boyfriend or girlfriend, and most of us who have been teenagers can probably remember the misery that our perception of our looks gave us.
There have been many theories as to the cause of acne, and it is highly likely that there is more than one. The basic reason for the appearance of acne is that oils, dead skin cells and bacteria block the pores of the skin to form a variety of different types of pimples or spots, such as whiteheads, blackheads and pustules than can be irritating or painful. They can also be very unsightly, affecting the face, neck and sometimes the chest and back.
Studies have indicated that acne is caused by the over-production of sebum, a fatty oily substance secreted by the sebaceous glands of the skin to keep it supple and lubricated. If this is excessive, the sebum can block the pores causing blackheads, and become infected causing acne. So what causes this excess production of sebum? There are theories that it could be due to high insulin levels in the blood.
High insulin levels are promoted by high blood glucose levels the more blood glucose in your blood then the more insulin your pancreas produces to help covert it into energy. Higher insulin levels are also associated with high levels of insulin-like growth factor 1 (IGF-1). The result of this is an increase in androgens (male hormones), specifically dihydrotestosterone (DHT), metabolized from testosterone. This in turn causes an increased production of sebum leading to acne.
The complete chain, therefore, begins with increased levels of glucose in your blood and ends in acne. In order to prevent acne you would have to break this chain anywhere in its sequence, and the only viable place to do this is at the beginning reduce your blood glucose level. In order to achieve this you would have to determine what foods you are eating that could cause an excessively high level of glucose in your blood.
Glucose is metabolized from carbohydrates, ranging from complex carbohydrates to refined sugar. However, those that you should try to avoid are the refined carbohydrates such as pasta, white bread, rice and sugar. These are what are known as the high glycemic index foods that can cause a sharp rise in your blood glucose levels when consumed. The complex carbohydrates take longer to be metabolized and are not so prone to producing sudden increases in your sugar levels. These lead to more Sustained and gradual increases in blood glucose that demand a steady insulin supply, rather than the sudden increase that can lead to acne. Such foods include high fiber whole grains, oats and the like.
Studies have indicated that twelve weeks on a diet of low glycemic index foods resulted in a significant reduction in acne symptoms when compared to a control that did not change their diet. It therefore seems likely that your nutrition can affect your acne, and that changes in your diet could lead to a significant long-term reduction in acne symptoms such as pimples, pustules and other types of lesion.
The same studies also proved a reduction in the androgen levels of those on the complex hydrocarbon diet compared to the controls, and also greater sensitivity to insulin. However, the test group also experienced a significant weight loss, and it was not conclusively proved whether the reduction in acne symptoms was due to the reduction in blood glucose levels or to the weight loss.
However, the result is in accordance with the insulin and androgen theory, and it is known that diabetes is connected with obesity, so the two might in any case be related. Acne, diabetes, and weight are all related to your blood sugar level, which is in turn related to diet and carbohydrate intake.
Although a low glycemic index diet is suggested, such a diet is not easy to apply properly, and a dietician could help you here. Persistence is the name of the game, and you will not see instant results. Note that the tests referred to above were over twelve weeks, and this is likely the minimum period you will need to stick to your diet. However, the minute you break it, and revert back to simple carbohydrates, your problem will return. There is no sudden cure, rather a continual dietary approach to the prevention of the condition. Acne is not a disease that you can catch and cure. It is a condition created by lifestyle and diet, and can only be controlled rather than cured until you grow out of it in your late teens or early twenties, although many people suffer from acne until later in life.
Your diet should include plenty of fresh fruit and vegetables, whole grains and cereals, brown rice, fish, eggs and lean meats. You should avoid saturated and trans fats, and eat unsaturated fats and oils, with plenty of omega fatty acids, vitamins and minerals for a good skin and good health. Exercise will help by improving the blood flow to your skin.
You can also help your condition by taking some specific supplements. Saw palmetto and zinc will help to reduce the levels of testosterone in your blood, and vitamins E and B6 are also believed to help. Selenium, pantothenic acid and essential fatty acids are other supplements that can help with acne, but your best bet is to discuss your condition with a naturopath or somebody trained in the use of natural remedies and supplements with your condition.
Many swear by tea tree oil, although treatment has to be prolonged over a length period before it becomes effective, but you might prefer this to one of the chemical testosterone blockers that can be prescribed for acne in certain cases.
Overall, acne is not a serious condition but can be disfiguring. Although you can seek medical help in the event of serious attacks, your recommended treatment initially is to eat plenty of healthy foods low in simple carbohydrates, to take the appropriate supplements and nutrients to keep you healthy and to take plenty of exercise to maintain a good blood supply to your face.
In these ways you can reduce the number, depth and lasting effects of acne pustules, and in many cases clear the condition altogether.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1680)
Date:
October 21, 2007 07:02 PM
The omnivore vs vegan argument as to who is right and who is wrong can be argued from a number of different platforms. There is the ethical issue of whether we should eat other animal life, and also the argument as which is ‘better for you’, based on arguments such as vitamin B12 is not available from a vegan diet. There is even the ‘lifestyle’ argument: does our lifestyle define our diet?
However, strictly, the only argument for or against either diet should only be made upon human biochemistry. Do both meet the needs of our biochemistry, or does one or the other lack something essential in our biochemical pathways? Obviously omnivores will lack nothing except by choice, since all foods are available for their consumption. If vegans do lack a specific chemical need, then is that available as a supplement in a form that can be effectively used in the chemistry of our bodies.
The one argument accepted by both sides is that it is essential for all animals to consume living things in order to stay alive themselves. These living thinks need not be alive at the time of consumption, but it is necessary that they eat the flesh of plant or animal life that at one time was alive and contained DNA. What that infers is that it is only vegetables that can survive on non-living tissue and this appears to be borne out in practice. No living animal known can live on inorganic matter only, but most plants can and do. Not all though, the Venus fly trap being an example.
It is easy to extend the moral problem of eating living tissue to living vegetable tissue that also contains DNA, and the argument must lie between animal and the derivatives of animals, and non-animal tissue. It has not yet been found that any organism has yet crossed the animal-vegetable divide, so the division is a valid one. That might seem obvious, but it is necessary to establish that for the argument between vegan and omnivore diets to be valid.
The consumption of protein derived from meat is not a prerequisite for size and muscle bulk, since the largest dinosaurs in the world were all herbivores, the largest being a member of the sauropod family at more than 175 tons, eclipsing the largest meat eater, the gigantosaurus at 8 tons. Thus, meat does not mean bulk. However, what has been proved is that the fastest creatures are carnivores. Hence if you want to be a top class sprinter, eat meat!
Carnivores, with their lean muscle mass and highly efficient quick use of available energy, have very short digestive tracts which are not good for digesting vegetable matter, but make best use of animal proteins and expel unnecessary mass from the body quicker. The argument in favor of the vegans is that the human digestive tract is not that of a carnivore.
In herbivores, the food takes longer to digest, and hence it remains in the digestive system longer. This means a longer alimentary canal, longer than humans have. Herbivores also move slowly, and a good example is the comparison of speed between the omnivorous chimpanzees and other small monkeys and the herbivorous gorillas and orangutans. On the one hand you have lean fast moving machines, while on the other you have large bellies and slow moving larger animals. Check out cows and sheep and compare their body fat with ours. Nor are we like herbivores.
So what are humans? Omnivores! Our teeth and intestines are those of omnivores, the teeth designed for ripping and tearing meat, and stripping leaves from trees, but also for grinding grains, and our intestines are something between the long and the short. People are able to eat and live on every type of food imaginable from brains to intestines to leaves to roots to ants and grubs.
The argument is therefore futile to consider historically. Let’s then study the advantages and disadvantages of each type of diet. Human beings are capable of life through consuming either animals or plants, or both. The argument seems, therefore, to be one of morality rather than biochemistry. However, is that really so? The vegan refusal to eat dairy products should not be taken as extremism, since the human being is the only animal species to drink milk of another species, or to use it to make other products. It is a practice born long after cattle were husbanded by humans for food. The problem with eating animal products lies not in the meat itself, but in the fat. Animal fat is saturated, which means that the fat molecule has no active double bonds in the chemical structure that can be used to break the fat down.
Animal fat also contains cholesterol, yet we cannot survive without cholesterol. It is the human band aid, used by the body to patch up damage to the cardiovascular system. Only, sometimes, too much is laid down and the arteries get blocked. However, many vegetable products have more saturated fats and cholesterol than many animal products, so a balance is called for. The unsaturated fats and oils for humans are said to be derived from seeds, such as flax seed and fish, especially oily fish. These are the Omega-3 oils. Although they can be obtained from some seeds and nuts, it has been proved that the best come from oily fish, such as wild salmon, mackerel and sardines.
The B vitamins are essential for life. The best sources are animal sources, though you get them from some vegetable sources such as brewers years (who eats lost of that?) and others, but animal sources are the best.
Also, there is no evidence to suggest that vegans live longer than omnivores. In fact all of the evidence indicates that a middle road is the best. For human beings the healthiest diet includes both meat and vegetable tissue. The best solution to good health is neither vegan nor carnivore. Nor is it traditional vegetarian, since it is the dairy products that cause many of our dietary products.
Studies of the biochemical pathways have demonstrated that all chemicals need to sustain healthy human growth and life are not available from a classic vegan diet. Some animal protein and B vitamins are essential that cannot be obtained form a normal vegan diet. It is possible, however, to maintain life by means of supplements.
However, for the healthiest form of human life, our biochemistry, history and physiology indicate that there is a balance somewhere between the extremes of both views that is right for us, and that either diet can be Sustained with appropriate supplementation based upon what is missing from one diet or the other.
So, omnivore vs vegan. Who is right: both are right if they also supplement any nutritional deficiencies in their diet with vitamins and minerals that may be lacking from one diet or the other.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1598)
Date:
May 18, 2007 01:06 PM
The Awesome Foursome: Coenzyme Q10, L-Carnitine,
D-Ribose, Magnesium
The “Awesome Foursome” of Coenzyme Q10, L-Carnitine, D-Ribose, and magnesium helps our hearts metabolize energy more efficiently and protects them from the stress of cardiovascular disease. This powerful combination of nutrients goes directly to the basic biochemistry of cellular energy metabolism. Now let’s take a closer look at how Coenzyme Q10, L-Carnitine, D-Ribose, and magnesium work in synergy to promote cardiovascular health.
Coenzyme Q10:
Energy Recycling through the Electron Transport Chain
Coenzyme Q10 is a powerful antioxidant that helps protect the mitochondrial membrane, mitochondrial DNA, and cell walls from free-radical attack. But its most important function in the body is its central role in energy metabolism.
Most – about 90 percent – of the ATP used by cells is recycled as food (fuel) and oxidized in the mitochondria. Fatty acids, carbohydrates, and, occasionally, proteins are carried across the mitochondrial membrane and enter the Krebs’ cycle, moving from step to step and spinning off electrons. These electrons are then handed off to the electron transport chain, where, in the presence of oxygen, the energy from the electrons is captured as a phosphate group is added to ADP to form ATP. This recycling of ATP is called oxidative phosphorylation, and the by-products of these pathways are CO2 and water.
In this fashion, Coenzyme Q10 acts as a gatekeeper of electrons, making sure they are carried to just the right place to pass on their life-giving energy.
What is critical, however, is the simple fact that without Coenzyme Q10 the electron transport chain would totally break down. And since the electron transport chain is (by far!) the largest contributor to cellular energy turnover, its loss would be catastrophic. It is also important to know that there has to be an excess of Coenzyme Q10 in the mitochondria to be maximally effective. Having just enough isn’t sufficient to do the job properly, and having a deficiency seriously affects the mitochondria’s ability to supply the cell with energy.
Cellular stress can cause Coenzyme Q10 deficiency, which places a severe strain on Coenzyme Q10 availability. People with heart disease, hypertension, gingival disease, Parkinson’s disease, and the other disorders we’ve discussed are known to be deficient in Coenzyme Q10. Whether these deficiencies are the cause or the effect of these varied medical problems, the end result is that they sap the life out of their mitochondria and reduce their energy supplies. You see, Coenzyme Q10 cannot function properly if electrons are not coming out of the Krebs’ cycle, and the Krebs’ cycle won’t work without the fuel that’s transported into the mitochondria by L-Carnitine.
L-Carnitine:
Transporting the Cellular Energy Fuel
Fatty acids are the preferred energy fuel for hearts and most other cells in the body. L-Carnitine facilitates the beta oxidation of fatty acids as energy fuel. And since fatty acids are the preferred fuel for energy recycling in cells, this action is critical to cell and tissue function. Unfortunately, L-carnitine is deficient in people with heart disease, peripheral vascular disease, lipid metabolic disorders, mitochondrial disorders, and many other disease syndromes we reviewed earlier. This L-carnitine deficiency disrupts the normal metabolism of fatty acids, reducing available energy supplies and leading to the accumulation of toxic by-products of fatty acid metabolism. L-carnitine supplementation revives fatty acid metabolism and restore normal mitochondrial function. But even this powerful improvement in cellular energy metabolism cannot up for the energy drain that comes from the loss of energy substrates caused by low oxygen delivery to the tissue. Only D-Ribose can do that.
D-Ribose:
Rebuilding the Cellular Energy Pool
As long as cells and tissues have plenty of oxygen, the pool of energy substrates in the cell remains high. And as long as there is enough L-carnitine and Coenzyme Q10 available, the process of energy utilization and supply can proceed unimpeded. However, the cellular supply of oxygen can be restricted by acute or chronic heart disease, peripheral vascular disease, any number of skeletal – or neuromuscular diseases, or even high-intensity exercise.
When cells are deprived of oxygen the mitochondrial energy turnover becomes inefficient. Remember, oxygen is required to let the oxidative pathway of energy recycling work properly. If the mitochondria are not able to recycle energy efficiently, cellular energy supply cannot keep pace with demand. But the cell has a continuing need for energy so it will use all its ATP stores and then break down the by-product, adenosine diphosphate (ADP), to pull the remaining energy out of this compound as well. What’s left is adenosine menophosphate (AMP). Since a growing concentration of AMP is incompatible with Sustained cellular function it’s quickly broken apart and the by-products are washed out of the cell. The net result of this process is a depletion of the cellular pool of energy substrates. When the by-products of AMP catabolism are washed out of the cell, they are lost forever. It takes a long time to replace these lost energy substrates even if the cell is fully perfused with oxygen again.
Ribose is the only compound used by the body to refill this energy pool. Every cell in the body has the capacity to make ribose, but hearts, muscles, and most other tissues lack the metabolic machinery to make ribose quickly when the cells are stressed by oxygen depletion or metabolic insufficiency. Ribose is made naturally in the cells from glucose. In stressed cells, however, glucose is preferentially metabolized for the energy turnover and is not available for ribose synthesis. So when energy pools are drained from stressed cells, the cells must first wait for the slow process of ribose synthesis before they can begin to replace their lost energy stores.
Acute ischemia, like that which takes place during a heart attack, heart surgery, or angioplasty, drains the cell of energy. Even when oxygenated blood flow returns, refilling the energy pool may take ten or more days. But when oxygen deprivation is chronic, or when energy metabolism is disrupted by disease, there may be so much continual strain on the energy supply that the pool can ever refill without the assistance of supplemental ribose. Conditions like ischemic heart disease or congestive heart failure fall into this category. In these situations, supplementing the tissue with exogenous ribose is the only way the cell can keep up with the energy drain.
Magnesium:
Switching on the Energy Enzymes
Magnesium is an essential mineral that's critical for energy requiring processes, in protein synthesis, membrane integrity, nervous tissue conduction, neuromuscular excitation, muscle contraction, hormone secretion, maintenance of vascular tone, and in intermediary metabolism. Deficiency may lead to changes in neuromuscular, cardiovascular, immune, and hormonal function; Impaired energy metabolism; and reduced capacity for physical work. Magnesium deficiency is now considered to contribute to many diseases, and the role for magnesium as a therapeutic agent is expanding.
Magnesium deficiency reduces the activity of important enzymes used in energy metabolism. Unless we have adequate levels of magnesium in our cells, the cellular processes of energy metabolism cannot function. Small changes in magnesium levels can have a substantial effect on heart and blood vessel function. While magnesium is found in most foods - particularly vegetables - deficiencies are increasing. Softened water and a trend toward lower vegetable consumption are the culprits contributing to these rising deficiencies.
Supporting the Links in The Energy Cycle Chain – the Synergy
Clearly, each membrane of the “Awesome Foursome” is fundamental to cellular energy metabolism in its own right. Each plays a unique and vital role in supplying the heart with the energy it needs to preserve its contractile force. Each is independently effective in helping hearts work through the stress of disease. And while each contributes immeasurable to the energy health of the cell, in combination they are unbeatable. Allow me to reiterate the step-by-step, complicated cellular processes involved to be sure that you really understand the rationale for using these nutrients.
The cell needs a large, Sustained, and healthy pool of energy to fuel all its metabolic functions. Contraction, relaxation, maintenance of cellular ion balance, and synthesis of macromolecules, like proteins, all require a high energy charge to carry their reactions to completion. The energy pool must be preserved, or these fundamental cellular functions will become inefficient or will cease to operate altogether. To keep the pool vibrant and healthy, the cell needs ribose. But even with supplemental ribose, the cell needs the efficient turnover of its energy stores to balance ongoing energy utilization with supply. That’s where CoQ10 and L-carnitine come into play.
The converse is also true. Even if the cell is fully charged with energy, cellular energy supply will not keep pace with demand if the mitochondria are not functioning properly. CoQ10 and L-carnitine work to keep mitochondrial operations running at peak efficiency, and one side cannot work effectively without the other. Even though CoQ10 and L-carnitine can make the energy turnover mechanisms work more efficiently, they cannot increase the cell’s chemical driving force, and their action will be only partially effective. Ribose on the other hand, can keep the energy pool supplied with substrate, but the value of energy pool repletion cannot be fully realized if the substrate cannot be maximally utilized and recycled. Ribose fills the tank; CoQ10 an L-carnitine help the engine run properly.
Magnesium is the glue that holds energy metabolism together. By turning on the enzymes that drive the metabolic reactions, magnesium allows it all to happen.
These four nutrients must be utilized by cardiologists and other physicians as they treat patients day-to-day. On my own journey, using Coenzymes Q10 for two decades, L-carnitine for more than ten years, D-Ribose for two years, and magnesium equally as long, I’ve seen this “Awesome Foursome” reduce suffering and improve the quality of life for thousands of patients.
The future of nutrition in conventional medicine is very bright, although the integration of nutritional supplements has been a slow and, at times, lonely process.
L-carnitine and Coenzyme Q10 are finally gaining the recognition they deserve. D-Ribose is emerging as a new player in the complex understanding of metabolic cardiology, and doctors are beginning to discuss the important role of magnesium deficiency in heart patients. As a practicing cardiologist for over thirty years, I see metabolic cardiology as the future for the treatment of heart disease and other complex disease conditions, as well.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1539)
Date:
December 11, 2006 03:46 PM
To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage.
Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis. 1,2,3
Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued. 3
Promotes optimal joint comfort, function and flexibility*
Boswellia serrata (Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal models without known side effects. 4
Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesis in vitro, promoting a healthy balanced production of these components of the immune system.5 Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.6 Other trials lend further support to Boswellia’s ability to promote healthy joint function.4,6,7
Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.8
Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response.9 Curcumin also demonstrates in vitro inhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.9,10,11
Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.12 Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results.
Bioperine-Nature’s Absorption Enhancer Boosts Nutrient Absorption*
Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.13 Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.14
Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. 15 These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability.
Sustained Release – For lasting joint comfort and convenient dosing
To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a Sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a Sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day.
Safety
Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.
Scientific References
2. Tapadinhas M.J., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68.
3. Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion 1982; 8(3):145-149.
4. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.
5. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R., and Ammon, H.P.T. (1992) Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146.
6. Boswellia serrata. Alternative Medicine Review Monographs – Volume One. 2002.
7. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5.
8. Majeed, M., Badmaev, V., Shivakumar, U., Rajendran, R. Curcuminoids: Antioxidant Phytonutrients. 1995. Piscataway, NJ: NutriScience Publishers.
9. Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae). The Protocol Journal of Botanical Medicine, Autumn 1995:43-46.
10. Rao, S., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol. 1997;49:105-7.
11. Ramsewak, R.S., DeWitt, D.L., Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308.
12. Deodhar, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of curcumin (diferoyl methane). Indian J Med Res 1980;71:632-34.
13. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of Ethnopharmacology 1981;4:229-232.
14. Bioperine®–Nature's Bioavailability Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa Corporation, Piscataway, N.J.
15. Shoba, G., et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998;64(4):353-6.
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Date:
September 19, 2006 09:12 AM
Persistent yeast infections may indicate a body out of balance.
Say the words “yeast infection” to the average woman and she’ll probably start to squirm. The burning, the itching we’ve all been there. Yeast’s miseries drive millions of desperate woman to seek relief each year.
Yeast infections (also known as yeast vaginitis) start when candida albicans, a naturally occurring fungus, starts growing excessively, producing itchy discomfort and a whitish discharge. Most every woman will endure a vaginal infection at least once during her lifetime, and many of these episodes will be caused by candida. (Bacteria or Trichomonas vaginalis may also be to blame; to be sure have the necessary testing done.)
When yeast strikes repeatedly you should look for an underlying cause. One of the biggest is the extended use of certain prescription drugs, particularly antibiotics, birth control pills or steroids. Another is the presence of undiagnosed diabetes. If you’ve been on meds, or have other diabetes symptoms such as excessive thirst or fatigue, see your practitioner.
A number of alternative health authorities—though by no means all-see recurring yeast vaginitis as part of a systemic candida infection, also called candidiasis. They believe it occurs when intestinal yeast over-growth causes the bowel wall to “leak” partially digested food and toxins into the blood, causing such symptoms as depression, digestive woes, fatigue, irritability and rashes even weight gain. The solution lies in a diet that tightly restricts sugar and other carbohydrates. To learn more www.yeastconnection.com.
Ditching the itch
In addition to addressing the underlying causes of persistent yeast infection you should also tame the beast where it lives. Fortunately, there are safe, natural therapies that can make life a lot more comfortable. Tea tree oil, a natural antiseptic available in both liquid and suppository form, may help, and aloe Vera gel can provide welcome itch relief. To bolster the effects of these topical treatments, some herbalists suggest taking cinnamon or the rainforest herb pau d’arco in supplemental form. Garlic, known for its antifungal properties, is another time-tested option.
After disposing of the harmful critters, replace them with helpful organisms. Organic plain yogurt, both eaten and applied directly, is a good source of these beneficial bacteria, especially when you add acidophilus or other probiotic supplements. Cutting down on your sugar consumption is always a good idea no matter what, as is upping your fiber intake (Oat bran is a good source).
To help keep things cool and airy, a little wardrobe management may be in order. Avoid tight, synthetic fabrics (sorry, but those cute spandex pants have just got to go) in favor of looser garments made with natural fibers, especially white cotton underwear. If swimming’s your thing, don’t spend to much time sitting around in a damp suit—change into something dry as soon as possible.
If you have got an itch that won’t go away, don’t just scratch. Learning what’s really going on is the better way to experience Sustained relief. –Lisa James.
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Date:
August 07, 2006 12:29 PM
It’s About Time
Solaray has enhanced the value of single dose products through its Two-Stage, Timed-Release process, which is designed to release vitamins to the body over a long period of time.
How are the ingredients designed to release over an extended period?
The active ingredients (Vitamin B 6) are encapsulated in a small sphere, which helps to prevent the actives from being released until the sphere walls are broken down over a period of time in the digestive system. The time of release is dependent on the thichness of the sphere walls. This helps the ingredients (Vitamin B 6) to be slowly released over a period of time. These walls are very thin, allowing them to be broken down easily and also requiring as much as 30% - 50% of the formula to be the timed-release agents. Solaray two-stage, timed-release products are intended to provide a higher level of actives with a lower level of timed-release agents.
First Stage: Half of the active ingredients (Vitamin B 6) are intended to be released immediately.
Second Stage: The remaining active ingredients (Vitamin B 6) are intended to be gradually released over an extended period of time. The goal is to lead to more balanced and Sustained levels of nutrients in the blood and ultimately, better cell utilization and overall benefit.
Available in 50mg 60ct, 100mg – 30ct, 60ct, and 120ct.
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Date:
December 30, 2005 08:53 AM
Every human being is at the mercy of their diet to provide them with a solid foundation of nutrients. This is especially true in the case of endurance athletes, bodybuilders and other adrenaline-seeking competitors. During intense physical training, the body calls upon its reserve of electrolytes such as potassium, magnesium, calcium and sodium to provide the spark needed for increased respiration, muscle contractions, nerve impulses and countless other functions.
A well-stocked cellular arsenal of these nutrients can ultimately lead to greater levels of Sustained endurance, muscular strength and mental clarity. Deprivation, on the other hand, is an invitation for disaster. When the body is pushed to extremes, but unable to locate what it needs, it becomes prone to fatigue, cramping, nausea and headaches. Not to mention, last place. Products such as Carbo Gain and ZMA can provide a solid base of nutrients. (See reverse for detailed specifi cations).
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Date:
July 13, 2005 12:30 PM
The results of isotopic testing confirmed that grape seed proanthocyanidins had a specific affinity for collagen, and demonstrated how long the bioflavonoid complex adhered to living tissue. Because this testing was not possible on pine bark sources of proanthocyanidins, data collected from grape seed testing has been extrapolated or applied to pine bark. Pycnogenol is rapidly absorbed and transported throughout the cellular system due to the high water solubility of the proanthocyanidins. Within one hour of ingesting this bioflavonoid complex, proanthocyanidins can be detectedin human saliva. Pycnogenol uptake in the body is rapid and is quickly distributed.
The bot tom line is that Pycnogenol is a water-soluble bioflavonoid which is quickly assimilated after ingestion into the bloodstream. There, it acts to scavenge free radicals and to strengthen connective tissue. The proanthocyanidins found in Pycnogenol can not only scavenge and remove free radicals, but inhibit their propagation as well.
THE TOLERABILITY AND SAFETY OF PYCNOGENOL
It would certainly be pointless to find a substance that while seemingly beneficial, was not safe or could not be well tolerated by its users. Studies have shown that pure sources of Pycnogenol are practically devoid of any oral toxicity. Even extremely high dosages administered over Sustained periods of time showed no toxicity or side-effects.14 Virtually no actual or potential risks were found with this compound. Pycnogenol has been shown to be safe for conception, pregnant women, and the unborn fetus. It is devoid of any perior postnatal toxicity. On the contrary, the compounds were found to not only benefit targeted disorders, but a variety of other conditions improved as well.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=609)
Date:
July 13, 2005 09:42 AM
Pycnogenol is a super antioxidant which consists of a highly bioavailable flavonoid called proanthocyanidin. This compound can be extracted from either pine bark or grape seed, and both sources are virtually identical. Biochemists will confirm that as a class, the proanthocyanidin bioflavonoids, regardless of their source, possess the same biochemical activity with very slight exceptions.
The differences lie in the varying concentrations of the flavonoid and its purity. Extraction processes for each source d i ffer and may contribute to the cost of the type of Pycnogenol in question. Regardless of its source, Pycnogenol has demonstrated extraordinary antioxidant capabilities.
NATURE’S BEST DEFENSE AGAINST FREE RADICALS: ANTIOXIDANTS
Potent substances called antioxidants, which scavenge for dangerous free radicals, afford us the best prospect for disease prevention, toxin protection and Sustained longevity and vigor. According to many experts, making sure we arm our cellular systems with adequate supplies of antioxidants should be our first health priority. “It has now been established that more than 60 human diseases involve free-radical damage, including cancer, heart disease and the acceleration of the aging process. All that you really need to know is that your body is under constant free - radical atta ck, and that you need to keep your antioxidant defenses strong.”1 The role of Pycnogenol as an exc e ptional free radical scavenger is just beginning to emerge, and the protective potential of Pycnogenol is impressive, to say the least. It’s only a matter of time before scientific data supports the fact that this family of nutrients is far more effective in its antioxidant capacity than previously assumed.
OTHER ANTIOXIDANTS
Some of the most common of free radical scavengers or antioxidants include:
While all of these are excellent cellular protectants, the compound missing from the above list may be the most remarkable of all.
PYCNOGENOL: THE HERCULES OF ANTIOXIDANTS
Pycnogenol provides some of the most potent compounds known to nutritionally support and potentiate the body’s defense system against oxidants. Continually emerging research supports the fact that Pycnogenol may be the best antioxidant nature has to offer. In this regard, it is 50 times more potent than vitamin E and 20 times more so than vitamin C.2 Pycnogenol is considered by some health experts to be the greatest nutritional breakthrough of our century.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=601)
Date:
July 12, 2005 10:16 AM
CHRONIC FATIGUE AND LIVER FUNCTION
A poorly functioning liver can underlie chronic fatigue including CFS (Chronic Fatigue Syndrome). Even if the liver has Sustained only minimal damage, the immune system can be compromised This effect has been observed in laboratory tests. For example, in some instances, liver injury has resulted in the rampant development of yeast infections throughout the body. The liver plays an integral role in so many other body systems and organs. Anyone who suffers fro m compromised liver function will experience chronic fatigue in combination with other symptoms.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=591)
Date:
July 12, 2005 10:01 AM
MILK THISTLE: A VITAL COMPONENT OF LIVER REHABILITATION
In addition to the flavonoid-like components of Silymarin, Milk Thistle seeds also contain betaine, which has proven itself as a liver protectant. Additionally, essential fatty acids are found in Milk Thistle which help control chronic inflammation.7
Milk Thistle should be a vital part of any therapeutic program designed to treat liver disorders. It can provide liver protection after exposure to radiation, heavy metals or toxic chemicals. Anyone who has hepatitis or cirrhosis should be using this herb as part of their treatment regimen. Concerning Milk Thistle and the liver, Christopher Hobbs wrote:
“I first learned of Milk Thistle in early 1984, when I began harvesting seeds from wild plants growing in California and taking the liquid extract I made from them. I had Sustained heavy damage to my liver as a result of having hepatitis twice, in 1963 and in 1967, and I was able to greatly restore my digestive power with the help of this herb. Since then, I have witnessed other surprising recoveries from severe liver ailments with the use of this herb.”8
There is no question that the Silymarin compounds of Milk Thistle have significant therapeutic value for liver diseases of various kinds including: hepatitis, fatty infiltration of the liver, cirrhosis, and inflammation of the bile duct.9
The tyramine and histamine content of Milk Thistle works to stimulate the production and flow of bile, which also benefits the liver. A whole host of laboratory tests from biopsies to clinical data confirm that Silymarin is particularly effective in treating and preventing liver damage from alcohol abuse or chemical exposure. Extensive clinical trails have clearly shown that Milk Thistle can reverse the symptoms of many liver disorders.
In addition, Milk Thistle can exert a therapeutic effect on chronic hepatitis, cirrhosis, fatty infiltration of the liver, cholestasis of pregnancy, cholangitis and pericholangitis.10 While the liver has a great capacity for regeneration, when it is diseased or damaged by toxins like alcohol, it can cease to produce badly needed liver cells. Milk Thistle can stimulate this proliferation. The earlier it is taken, the quicker recovery will be.
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Date:
June 25, 2005 01:03 PM
Many studies have been done to determine the effectiveness of ginseng in a variety of countries. Incomplete results have occurred in some instances. Long-term studies are most often recommended because ginsengs properties may not be seen in immediate experiments but are more effective when taken in small doses over a period of time. There have been enough credible studies done to now determine that high quality ginseng plants do contain active constituents known to be beneficial. Research has shown that the roots are effective against bronchitis and heart disease.16 Ginseng has been found to reduce blood cholesterol, build the immune system, improve brain function and memory, increase physical stamina, stimulate the function of the endocrine glands and strengthen disorders of the central nervous system.
Physical and Mental Stamina
A study down in the late 1950s and early 1960s by Brekhman and Dardymov in Russia involved an experiment with Soviet soldiers. They were studying the pharmacology and reactions of different varieties of East Asian ginseng. Some were given an extract of Asian ginseng and others a placebo before running a 3-kilometer race. Those given the ginseng ran faster with less fatigue than those given the placebo.17 Other tests performed by Brekhman involved gauging reading capacity after taking ginseng. It was noted that not only was the work and reading ability improved, but the effects continued for up to six weeks after the treatment.18
Another study giving radio operators either an Asian ginseng extract or placebo. The group given the ginseng performed better with fewer mistakes. The ginseng helped to increase stamina and mental function.19 A study involving rats followed the results when they were put in extremely cold water and forced to swim for a long period of time. The rats given the Asian ginseng were able to swim longer than the control group which indicated anti-fatigue activity. It is also important to note that ginseng increased the recovery rate of the exposed rats. The process was initiated in order to see if the point of exhaustion could be increased with the addition of ginseng. The results were favorable.20
Ginseng seems to be able to help slow glycogen utilization in the muscles when exercising. Fatigue accom-panying prolonged exercise is due in part to the depletion of glycogen and lactic acid build-up. Fatty acids are used as the energy source when there is enough oxygen available to reach the muscles reserving the glycogen stores to increase the body’s performance and reduce fatigue.21 Athletes may benefit from using ginseng to help improve and prolong their performance and abilities under stress during training and competition.
Serious athletes throughout the world use ginseng regularly. Some Olympic athletes take ginseng daily to increase and enhance their physical performance. Siberian ginseng has been found to help improve mental abilities in geriatric patients.22 This may be of benefit to all individuals as they age especially those prone to senility and Alzheimer’s patients. It is also thought to help an aging heart and brain tissue under stress and Sustained work.23
Siberian ginseng has also been found to help increase energy and performance. Japanese medical researchers studied the extract of Eleuthero ginseng to determine anti-fatigue activity. The results showed increased physical performance and ability after taking the ginseng.24
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=474)
Date:
June 25, 2005 12:00 PM
Smell Perception, Hearing and Ginkgo
Over 200,000 visits to the doctor annually are due to lack of smell or the diminished ability to smell properly. In addition, an abnormally heightened sense of smell can also be a problem.
Interestingly, these types of smell disorders are commonly seen in people suffering from Alzheimer’s disease or Parkinson’s disease. Both of these disorders are the result of faulty bio-chemical reactions in the brain. Ginkgo is one of the supplements that has been re p o rted to help smell perception. Effective dosages would depend on the degree of severity and the current nutritional status of the person. Ginkgo as a Treatment for Tinnit us When circulation is improved, frequently hearing does as well.
Ginkgo helps to oxygenate tissues more effectively which can enhance nutrient transport to the nerves of the inner ear. As a result, conditions such as tinnitus (ringing in the ear) may be alleviated. Tinnitus is a very difficult condition to effectively treat. If the tinnitus is the result of a circulatory deficiency, ginkgo may be effective. The role of ginkgo as a viable therapy for the disord e r remains somewhat controversial.
In terms of treating tinnitus with ginkgo, experimentation is the best approach. Tinnitus can be caused by a number of differe n t problems and the search for an effective treatment can only be made by the individual. In addition, treatment must be Sustained for a long period of time before any judgement can be drawn. A minimum of two weeks is necessary. For more seve re cases of tinnitus, a longer period of therapy is required. German tests using ginkgo for sudden hearing loss suggested that in cases where hearing is lost for no apparent reason, ginkgo was effective in promoting a remission after one week of treatment. In some cases, hearing was also improved.11 One of the main advantages of using ginkgo over other drugs for hearing loss is that it is considered safe with minimal side effects.
Deafness Due to Compromised Blood Flow
In some cases of cochlear deafness, ginkgo has proven to be a valuable therapeutic agent. As in the case of tinnitus, treatment should be initiated and Sustained.
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Date:
June 14, 2005 05:06 PM
Energize Your Life!
by Laura Weiss Energy Times, December 1, 2003
If every fatigued day leaves you wondering where your energy went, you need a personal energy makeover.
"Energy, some special kind of energy, just leaks out and I am left lacking the confidence even to cross the street," Diane Arbus, the photographer, once complained. And while Ms. Arbus tried to overcome her energetic and spiritual ups and downs with her art, you can use lifestyle changes as well as self-expression to revive your vigor.
To Sleep, Perchance to Energize
When you're looking for a boost in personal energy, you've got to get enough sleep, insists Jacob Tietelbaum, MD, author of From Fatigued to Fantastic! (Avery). Dr. Teitelbaum emphasizes that unless you "give your body eight to nine hours of sleep per night," your personal energy will never be adequate.
Studies show that getting less than six hours sleep a night hurts your mental performance and drains your energy (Sleep 3/15/03). As your sleep debt builds up, your energy drops down.
"[Our studies show] the importance of sleep as a necessity for health and well-being. Even relatively moderate sleep restriction, if it is Sustained night after night, can seriously impair our neurobiological functioning," says Hans P.A. Van Dongen, PhD, Assistant Professor of Sleep and Chronobiology at Penn State.
A recent poll by the National Sleep Foundation found that Americans, on average, are getting less than seven hours of shuteye a night. That sleep deficit drains energy.
Watered Down Energy
Added to that sleep requirement, Dr. Teitelbaum stressed in an interview with Energy Times, a lack of water can deplete your personal energy.
"The number one problem is often dehydration," he says. "Make sure you stay hydrated. Although I think it's a bad idea to [obsessively] count glasses of water, you should carry a bottle of water with you, check your lips and if they feel dry drink more water." Overall, your body is about 60% water and 70% of your muscles consist of water. If you let your water levels dip too low, your muscles suffer and your energy levels dip as well. Research shows that as your body dries out, your mental processes can slow down. And the hotter the temperature, the more fluid you may lose (AIHAJ 2002; 63(2):190-8).
B Vitamins for Energy
Also important for keeping your energy up "is getting enough of the B vitamins and magnesium." And even though Dr. Teitelbaum advocates the necessity of a well-rounded multiple vitamin and mineral supplement plus an adequate diet and amino acids to get all the nutrients you need, he recommends "taking a high-level B complex. The RDAs (the government's Recommended Daily Amounts) are inadequate."
In the body, B vitamins are used for the production of energy on a cellular level. For instance, vitamin B1 (thiamine) is crucial for burning carbohydrates effectively. And vitamin B6 (pyridoxine) is necessary for the body's ability to properly use B1. At the same time, vitamin B12 (cobalamin) is required for proper nerve function. The need for B12 may necessitate a supplement: Up to 30% of everyone over the age of 50 may have trouble absorbing B12 from their food (Crit Rev Clin Lab Sci 1996; 33:247). Plus, since vegetables contain very little absorbable B12, vegetarians of all ages may also require B12 supplements.
Dr. Teitelbaum also believes that taking malic acid, a nutrient derived from apples, can help. Along with the B vitamins, malic acid is used by the body in the production of energy. When taken with magnesium, malic acid has been shown to ease the pain of fibromyalgia (J Rheum 1995; 22(5):953-7), a condition characterized by fatigue and lack of energy accompanied by painful muscles and joints.
Ginseng Boost
Asian ginseng (Panax ginseng) represents a potential tool for controlling blood sugar and improving stamina.
According to Dr. Teitelbaum, "...Asian ginseng enhances energy, raises blood pressure and improves adrenal function...Asian ginseng has such a wide mix of health benefits that its name, Panax, comes from the Greek roots of pan (meaning 'all') and akos (meaning 'cure')-that is, 'cure all.'"
Research on people with diabetes shows that this herb may help control blood sugar levels. People who suffer what is called type 2 diabetes often eat small meals to keep their blood sugar from varying too much. (Rising and falling blood sugar can drain you of energy as well as make diabetic problems worse.)
An investigation of how another form of ginseng, American ginseng (Panax quinquefolius), affects blood sugar after eating found that it tempered changes by up to 20% (Arch of Internal Med 4/00). These scientists found that folks with diabetes did best when they took the herb within two hours of a meal.
Ready to re-energize? Time to stop skimping on sleep and rushing through inadequate meals. For all of us, slowing down and giving our bodies a chance to regenerate its zip can make the big energy difference.
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Date:
June 12, 2005 02:33 PM
Snack Attack by Chrystle Fiedler Energy Times, August 5, 2003
Americans are snackers. For instance, during the Superbowl, we munch on about 125,000 pounds of pretzels, chips, popcorn and nuts a minute; 30 million pounds by the end of the game. At work about half of us snack two or three times a day. By the end of today, as a group, we'll have eaten $22 million worth of candy-almost a million dollars an hour for every hour of every day.
If you snack unwisely, these munchies can expand your waistline and sabotage your health. But if you snack wisely, you can keep your taste buds fulfilled, your brain working at top capacity and your body satisfied.
When searching for snack satisfaction, think protein. Protein bars and protein shakes keep you feeling fuller longer on fewer calories than sweets.
Second to protein, think fiber, as in fresh fruit, dried fruit, or whole grain breads and crackers.
Unlike carbohydrates that break down into sugars and may be quickly stored as body fat, protein-rich snacks release sugar into your bloodstream at a slow, steady and healthy pace. That keeps you satisfied longer on fewer calories.
"Protein is an important building block (for the body)," says Alicia Gonzalez, ND, a teaching fellow at Bastyr University in Kenmore, Washington. "It breaks down into amino acids as precursors to things like neurotransmitters, hormones and muscle."
Besides eating protein-rich snacks, eat protein with every meal and eat it first. "It will help your body absorb sugar at a slower rate."
"Protein and fiber are the best at helping the body absorb sugar at an optimal rate," says Jon Gordon, author of Become an Energy Addict (Longstreet Press).
"Protein bars release sugar at a slower rate, resulting in more balanced blood sugar levels and greater overall energy," Gordon says. "You'll crave sugar less and will have a more Sustained source of energy all day long."
Protein Bars' Power
"The biggest advantage of protein bars, besides their convenience, is the fact that they do have considerably more protein, say 10 grams, than candy bars, which can contain as little as 2 grams," says Dr. Gonzalez. Total fat tends to be much less in a protein bar, too.
When choosing a protein bar, Dr. Gonzalez says, "Look for total protein content, say, between 10 and 12 grams and total fat, no more than 5 grams, and be careful with high sodium content."
"Choose a protein bar closest to nature," says Gordon. "Like one with almonds and cashews. Nuts are full of nutrients and minerals. Nuts are also a source of fiber."
If you exercise, protein bars with whey or soy protein make for quick replacement of necessary nutrients. "Eating a protein bar an hour before exercising helps to maintain that energy boost you need and replenishes minerals you lose when working out," says Dr. Gonzalez.
Some protein bars, though, do a bait n' switch with saturated fats and trans fatty acids, says Dawn Weatherwax, RD, author of The Official Snack Guide for Beleaguered Sports Parents (WellCentered Books). "If the label says hydrolyzed or hydrogenated palm oil, that's as bad as saturated fat. People think they're doing the healthy thing by eating a protein bar but they end up getting the wrong type of fat."
Besides protein bars, other healthy and healthful snacks include whole grain bread with peanut butter and cheese on whole grain, high-fiber crackers. "Mixing fiber and protein will help you sustain your energy," says Gordon. "Yogurt is also very good."
Smooth Sailing
"Smoothies are also wonderful (snacks)," says Weatherwax. "Add protein powder, silken tofu and fruit to them and you can have them as a meal replacement."
"Nuts like cashews, almonds, seeds and dried berries are some of the best snacks that you can eat because you're not getting all that sugar," says Dr. Gonzalez. "Nuts have a good balance of good fat versus bad fat, including essential fatty acids, which are really important for cellular health and overall well-being. A combination of nuts, seeds and dried berries provides you with a good mix of all the vitamins and minerals along with the good fats that you need to be healthy."
When snacking, think about variety. "Mix it up, have a protein bar one day, a protein shake the next," says Gordon. "Combine protein with a healthy carbohydrate and you'll have much more Sustained energy throughout the day."
Fuel for Your Fire
"We're like a train, we need to keep the furnace stoked," says Weatherwax, a consulting dietitian for the Cincinnati Reds baseball team. "The goal is to eat every three or four hours. You have breakfast and lunch and you need an afternoon snack. That's the hardest one to get. Most people don't want to eat another sandwich; they want snack food. So a protein bar with a carb like a piece of fruit, an apple, orange or banana...is a great combination." "Studies show if you have moderate-size meals plus small between-meal snacks you increase your levels of energy and alertness," says Gordon. "It also optimizes your memory and performance and gives you a steady flow of energy rather than the rises and falls. Without healthy snacks your blood sugar falls and you experience fatigue and tension. Just as we need to constantly feed a fire with moderate-sized pieces of wood, we also need to continually supply our internal furnace with food that can be turned into fuel. This keeps our metabolism going strong and steady."
"You want to stay between one-third and two-thirds full," adds Weatherwax.
"Eating less in an effort to lose weight is actually deleterious in the long run," says Dr. Gonzalez. "When we don't eat our body gets mixed signals; it isn't sure when it's going to get its next meal. This makes the body want to store fat and sugar to save it just in case. On the other hand, if your body becomes accustomed to eating more often, the cells will be more inclined to use the fat up, knowing there is more food on the way."
To program your body this way, don't skip meals. Have protein-filled breakfast like a protein smoothie and eggs. Follow up with healthy snacks like a protein bar or shake and regular meals.
"Ideally, it's best to combine the macronutrients, the protein, carbs and healthy fats," says Weatherwax. "By mixing all three you actually burn more energy. One study shows that you burn an extra 35 calories."
Nibbling on refined sweets can give you the snack blues. So let smart-snack strategies. Shift your mental outlook into high gear and use snacks wisely.
Snacking and Exercising
When you incorporate snacks into a consistent exercise program, you boost your chances of maintaining a healthy weight.
To make a big difference in your day, Gordon says, get up a half an hour early to exercise. Next, eat a breakfast that includes protein and fiber, have a mid-morning snack, a healthy lunch, an afternoon snack and good dinner. Take a walk within 30 minutes of eating dinner and you'll give your body a double dose of get-up-and-go.
"It exponentially increases your energy production and fat burning," says Gordon. Do all these things and watch your energy soar. "You'll fuel your life with real Sustained power sources rather than the quick fix like coffee that's going to give you the rise in energy and then fall."
You don't need to be told to keep on snacking. Just keep to the protein and fiber side of the snack street.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=308)
Date:
June 03, 2005 05:35 PM
NUTRASPRAY represents a quantum leap in the evolution of supplementation, an elegant combination of convenience, fast action, bioavailability, and Sustained release delivery. Source Naturals has long championed the sublingual delivery system, and our Super Sublingual™ is the latest step in the science of nutrition. A quick spritz of NUTRASPRAY under the tongue delivers thousands of microscopic lipid spheres, each full of nutrients. These lipospheres are readily absorbed and retained by the mucosal tissue of the mouth. Here they release their nutrients quickly, but steadily, into the bloodstream – creating a Super Sublingual, the most bioavailable supplement today.
Nutrient delivery systems include tablets, capsules, softgels, and liquid extracts. Their purpose is to ensure the cells in your body get the nutrients they need from the supplements you take. Sublinguals bypass the digestive system – and its potentially destructive juices – by dissolving under the tongue to be directly absorbed into the bloodstream. Tests show that the NUTRASPRAY liposome sublingual delivery system is more efficient than traditional sublinguals.
The First Timed Release Sublingual
Due to the multi-layered structure of the tiny lipospheres, nutrients are gradually released for extended periods of time, maintaining optimal dosage throughout the day or night. This combined with a faster onset of the active ingredients – usually within 15 minutes – makes NUTRASPRAY the most bioavailable delivery system for nutritional supplements today, and the first truly timed release sublingual.
Unparalleled Convenience
NUTRASPRAY incorporates a simple, non-aerosol spray pump that’s easily carried in purse or pocket. Its modern functional design is a perfect complement to today’s active lifestyle. It’s easy to regulate nutrient amount, because the convenient pump delivers a specific amount of nutrient-rich liposomes with every spray, and each 2 fl. oz. recyclable plastic bottle can deliver 80 full sprays. Stevia is added as an ingredient in each NUTRASPRAY product.
Advanced Research
The lipid micro-encapsulation process is based on years of research in liposomal technology. The result is NUTRASPRAY, a proprietary system to deliver nutrients in the most efficient manner. This sublingual oral spray is a liquid suspension of liposomes, which are nutrients encased in very complex microscopic lipid spheres, 1/50th the diameter of a human hair. A highly purified natural lecithin forms the membrane of these lipid spheres, which are able to move easily through the lipid environment surrounding the capillaries in the mouth. Lipospheres then gradually release their nutrients into bloodstream.
Nutrients That Go To Your Head
The Source Naturals NUTRASPRAY line includes natural supplements that are particularly well-suited to this Super Sublingual delivery system, such as Melatonin, Ginkgo Biloba, Coenzyme Q10, Grape Seed extract, and Kava. That’s because these nutrients need to reach the brain for maximum benefit. Also, they’re usually taken for reasons that the fast-acting quality of NUTRASPRAY satisfies. Another unique reason NUTRASPRAY is so bioavailable is that its nutrients bypass the liver on their first pass through the circulatory system. This ensures the nutrient is available to the brain for maximum potency. Source Naturals NUTRASPRAY MELATONIN delivers 1.5 mg of the finest quality Melatonin with each full spray, easily allowing customers to control their intake. Melatonin is ideally suited to the fast-acting nature of NUTRASPRAY, which maintains a more balanced release of Melatonin throughout the night. Source Naturals NutraSpray GINKGO-24™ provides 60 mg of Ginkgo Biloba per full spray. This makes Ginkgo’s beneficial constituents readily available to the capillaries in the blood-brain barrier, facilitating oxygen flow to the brain. CoQ10 is fat soluble; therefore encapsulating it in a lipid is the perfect way to ensure its bioavailability. Each full spray of Source Naturals NUTRASPRAY™ COQ10 yields 30 mg of CoQ10. Furthermore, this popular metabolic enhancer is very experiential with the NUTRASPRAY delivery system. NUTRASPRAY GRAPE SEED extract delivers 50 mg per spray of proanthocyanidins standardized to 95%. These highly bioavailable flavonoids are able to cross the blood-brain barrier, offering potent antioxidant protection to precious neurons. NUTRASPRAY KAVA KAVA is a potent extract standardized to a potent 40% kavalactones, the active constituents of this traditional root from the Polynesian cultures of the South Pacific. The relaxing action of Kava works through the brain’s limbic system, which regulates emotions related to survival issues, including the “fight or flight” response. Each spray yields 60 mg of Kava. Look for other fine products soon to come out in the Source Naturals line of NUTRASPRAYS. Source Naturals built its reputation on bringing the latest nutritional research to market, using the finest ingredients in substantial quantities – for an experience of wellness and vitality you can feel. Source Naturals NUTRASPRAY is a major step toward empowering people to achieve optimal health in a challenging world.
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Date:
June 02, 2005 12:07 PM
Your heart is crucial to every function of your body. It is the sole organ which pumps oxygen-rich blood through the entire circulatory system, feeding your cells and making life possible. Only recently are Americans realizing the importance of a proper low-fat diet, regular exercise, giving up cigarette smoking, and cutting down alcohol consumption to maintaining a healthy heart. Unfortunately, there has been a huge gap in the number of nutritional supplements which provide nutrients and herbs to support normal heart function. That’s where Source Naturals HEART SCIENCE comes in. Two years in the making, and backed by numerous scientific studies, the nutrients in HEART SCIENCE are some of the most soundly researched of all. Combining high potencies of these super-nutrients, HEART SCIENCE is the most comprehensive, cutting edge nutritional approach to proper heart care available.
Source Naturals HEART SCIENCE— The Five Tiered Approach to Heart Health
Your heart never rests. Even while you sleep, your heart must keep working, relying on the constant generation of energy by the body for its very survival. If this vital organ stops beating for even a short amount of time, all bodily functions cease and life ends. Source Naturals HEART SCIENCE helps support heart function on the chemical, cellular, structural, and energetic levels. This broad spectrum formula includes ingredients specifically geared for
Energy Generators for An Energetic Organ
Every day, the human heart beats about 104,000 times, pumping over 8,000 liters of blood through the body! Because it requires so much energy to perform efficiently, the experts at Source Naturals included specialty nutrients in HEART SCIENCE such as Coenzyme Q10 and L-Carnitine — integral factors in the body’s energy production cycles — to enhance the body’s energy supply.
There are three main interconnected energy generating cycles in our cells — the Glycolytic (sugar-burning) cycle, the Krebs’ (citric acid) cycle, and the Electron Transport Chain. Together they supply about 90 to 95% of our body’s entire energy supply, using fats, sugars, and amino acids as fuel. Coenzyme Q10 is one of the non-vitamin nutrients needed to maximally convert food into ATP (the energy producing molecule). It is the vital connecting link for three of the four main enzyme complexes in the Electron Transport Chain, the next step in energy generation after the Krebs’ cycle. Using the raw materials generated by the Krebs’ cycle, the Electron Transport Chain produces most of the body’s total energy! The heart is one of the bodily organs which contains the highest levels of CoQ10, precisely because it needs so much energy to function efficiently.
CoQ10 is one of the most promising nutrients for the heart under investigation today. It has been postulated that as a result of its participation in energy production, CoQ10 improves heart muscle metabolism and the electrical functioning of the heart by enhancing its pumping capacity.8 Many factors such as a high fat diet, lack of exercise, and cigarette smoking can lead to suboptimal functioning of the heart, and therefore failure of the heart to maintain adequate circulation of blood. Interestingly, people whose lifestyles reflect the above factors also tend to have depleted levels of CoQ10 in the heart muscle.10
Researchers suggest taking between 10-100 mg per day of CoQ10;18,29 HEART SCIENCE provides an impressive 60 mg of CoQ10 per 6 tablets. Similar to CoQ10, L-Carnitine is important for energy production in heart cells. It is a natural amino acid-like substance which plays a key role in transporting fatty acids, the heart’s main source of energy, to the mitochondria, the “power plants” of each cell, where they are utilized for the production of ATP. Heart and skeletal muscles are particularly vulnerable to L-Carnitine deficiency. Studies have shown that supplementation with LCarnitine improves exercise tolerance in individuals with suboptimal heart and circulatory function, and seems to lower blood lipid status and increase HDL (good) cholesterol.16, 22 Each daily dose of HEART SCIENCE contains 500 mg of this extremely important compound.
Like CoQ10 and L-Carnitine, B Vitamins help improve the ability of the heart muscle to function optimally. Each B Vitamin, after being converted to its active coenzyme form, acts as a catalytic “spark plug” for the body’s production of energy. Vitamin B-1, for example, is converted to Cocarboxylase, which serves as a critical link between the Glycolytic and Krebs’ Cycles, and also participates in the conversion of amino acids into energy. A deficiency of B coenzymes within contracting muscle cells can lead to a weakened pumping of the heart.21
HEART SCIENCE is formulated with high quantities of the most absorbable forms of B Vitamins providing maximum nutrition for the high energy demands of heart cells.
Homocysteine Regulators
B Vitamins also play a crucial role in the conversion of homocysteine, a group of potentially harmful amino acids produced by the body, to methionine, another more beneficial amino acid. While it is normal for the body to produce some homocysteine, even a small elevation in homocysteine levels can have negative implications. It is well documented that individuals who are genetically predisposed to having elevated homocysteine levels (homocysteinemics) tend to have excessive plaque accumulation in the arteries and premature damage to endothelial cells (cells lining the blood vessels and heart).26 Researchers have found that even those without this genetic abnormality, whose homocysteine levels are much lower than those of homocysteinemics, still have an increased risk for premature endothelial damage and the development of plaque in the arteries.24, 26 One study conducted among normal men and women found that those with the highest levels of homocysteine were twice as likely to have clogged arteries as were those with the lowest levels.24 Furthermore, it was found that the lower the research subjects’ blood levels of folate and B-6, the higher their homocysteine levels.24 Another study found that Folic Acid administered to normal men and women who were not even deficient in folate caused a significant reduction in plasma concentrations of homocysteine!3 In order to regulate homocysteine levels, it is critical to provide the body with sufficient amounts of B-6, B-12, and Folate, whether through the diet or through supplementation. HEART SCIENCE includes high levels of these three nutrients, providing B-6 in the regular and coenzyme form for maximum utilization.
The Dangers of Oxidized LDL Cholesterol
While many people have heard that high cholesterol levels may negatively affect normal heart function, few people understand exactly what cholesterol is, or how it can become harmful. Cholesterol is a white, waxy substance produced in the liver by all animals, and used for a variety of necessary activities in the body. Your liver also manufactures two main kinds of carrier molecules which transport cholesterol throughout the system: Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Cholesterol is either carried out by LDL from the liver to all tissues in the body where it is deposited, or carried back by HDLs which remove cholesterol deposits from the arteries and carry them to the liver for disposal. Because of this, LDL cholesterol is considered damaging, while HDL is considered protective. Problems occur when there is too much LDL cholesterol in the body and not enough HDL.
When the body becomes overloaded with fat, an over-abundance of LDL particles are manufactured to process it, and they in turn become elevated in the body to a degree that the liver cannot handle. Rich in fatty acids and cholesterol, these particles are highly susceptible to free radical attack (oxidation). Once oxidized, LDL particles are no longer recognized by the body, which attacks them with immune cells. Immune cells which are bloated by oxidized lipids (called foam cells) are a key factor in the development of “fatty streaks” — the first sign of excess arterial fat accumulation. The bloated immune cells accumulate in artery lesions and create plaque in blood vessels, leading to obstruction and constriction of the vessels. Plus, these lodged foam cells continue to secrete free radicals into the bloodstream, making the problem worse.
The development of lesions in the arteries is not an uncommon problem. Arterial (and all blood vessel) walls are composed of a chemical matrix which holds the endothelial cells in place. That endothelial layer is the first and most important line of defense in preventing large molecules, such as cholesterol and fat, from entering the vessel wall. This matrix is composed of proteins, collagen, elastin, and glycosaminoglycans (amino sugars). Arterial lesions can be caused by suboptimal collagen and elastin synthesis due to three factors: 1. Vitamin C deficiency (since Vitamin C is a key building block for collagen and elastin); 2. excessive consumption of rancid fats, or heavy usage of alcohol or cigarettes; and 3. free radical damage. Once these lesions are created, the body attempts to repair them by depositing LDL cholesterol — similar to the way one would patch a tire. If that cholesterol is not oxidized, i.e. chemically changed to a harmful, unstable molecule, then this process does not create a problem. But when arterial lesions are “patched” with foam cells, arterial walls suffer page 3 page 4 even more damage, because those foam cells release free radicals which can further damage cell membranes.
Unfortunately, most people have a lot of oxidized cholesterol floating through the bloodstream. The typical American diet, with its low antioxidant intake and overconsumption of fried and overcooked foods, contributes to the overall levels of harmful oxidized cholesterol. In fact, the average American intake of antioxidants is low even by USRDA standards, making Americans particularly prone to having high levels of oxidized cholesterol.
Cholesterol Fighters
Fortunately, there are concrete steps you can take to prevent the oxidation of cholesterol, and its subsequent ill effects on health. In addition to cutting out high-cholesterol and fatty foods, supplementation can protect existing cholesterol and all tissue cells — from oxidation. Antioxidants, substances which scavenge and neutralize free radicals, protect the cardiovascular system by halting the oxidation of cholesterol, and helping to prevent plaque accumulation in the arteries and the continual secretion of free radicals by foam cells. Supplementing the diet with high amounts of Vitamin C, a key antioxidant, also encourages a more healthy “patching” of existing lesions by using collagen (made from Vitamin C) instead of cholesterol. HEART SCIENCE contains generous amounts of the following antioxidants for their protective benefits:
The Regulating Trio
Three nutrients — Magnesium, Potassium, and Taurine — work closely together in the body to help maintain the normal electrical rhythm of the heart, promote proper fluid balance, and prevent excessive Calcium levels from building up in the heart and artery linings.
Artery Lining Protectors
Your arteries form an integral part of your cardiovascular system, carrying blood away from the heart to nourish other parts of the body. In a healthy heart, blood surges through the arteries with every beat of the heart. The arteries expand with each pulse to accommodate the flow of blood. When arteries become hardened and narrowed by the build-up of plaque, they can’t expand and are not able to transport blood efficiently throughout the body. This inability to open up increases blood pressure, putting a strain on the heart as well as the arteries. HEART SCIENCE includes ingredients specifically geared to protect against plaque formation within arteries and maintain the flexibility of these vital blood vessels. N-Acetyl Glucosamine (NAG) is a key amino sugar which forms the building blocks of mucopolysaccharides. Mucopolysaccharides, which are long chain sugars, are an integral component of connective tissue. They combine to form gel-like matrixes which are present throughout tissues in the body, helping to maintain the elasticity of blood vessels which must continually adapt to the changing pressures of blood flow. Each daily dose of HEART SCIENCE provides 500 mg — a substantial amount — of this vital tissue building block. There is evidence indicating that Silicon, a natural mineral, may protect against plaque formation in the arteries. Silicon is found mainly in connective tissues, where it helps bind the body’s chemical matrix. Bound Silicon is found in high amounts in arterial walls. Researchers have found that there is a steady decline in the Silicon content of the aorta and other arteries as we age. This may be due to the low fiber content of the typical American diet, since fiber is a key dietary source of Silicon.23 HEART SCIENCE includes 400 mg of Horsetail herb extract, a natural source of Silicon. Hawthorn Berry is without question the herb most widely used to encourage normal heart function. The beneficial actions of Hawthorn Berry on cardiac function have been repeatedly demonstrated in experimental studies. Supplementation with Hawthorn Berry has been shown to improve both the blood supply to the heart by dilating coronary vessels, and the metabolic processes in the heart, resulting in normal, strong contractions of the heart muscle.34 Also, Hawthorn may inhibit the angiotensen converting enzyme, which is responsible for converting angiotensen I to angiotensen II, a powerful constrictor of blood vessels.34 Bromelain, a natural enzyme derived from pineapples, has become well-known for its neuromuscular relaxing properties. Researchers have reported favorable results when using Bromelain for soothing vascular linings. Initial research also indicates that Bromelain may break down fibrin, the glue which holds platelets together to form blood clots.6
Capillary Strengtheners
Capillaries are the smallest, yet some of the most important, blood vessels. If you think of your cardiovascular system as a series of roads which transport blood and oxygen, then your arteries are akin to interstate highways, your arterioles are the main city boulevards, and your capillaries are local residential streets. Capillaries are so small, in fact, that single red blood cells actually have to fold up to fit through them. Because of their tiny size and the intricate nature of their network throughout the body, capillaries are responsible for actually nourishing each individual tissue cell! Along the length of the capillaries are small openings called slit pores through which oxygen, glucose, and nutrients leave the capillaries and enter the surrounding interstitial fluid. From there, they cross cell membranes and nourish the cells. Similarly, the waste products of cells enter the fluid and cross over into the capillaries, where they are then transported to the liver and kidneys for disposal. If the capillary slit pores are torn or have lesions, then blood proteins and Sodium will leak out and cause the interstitial fluid to take on a more gel-like nature. This makes the transfer of oxygen and nutrients to the cells more difficult, as well as the disposal of cell waste products, turning the fluid into a stagnant swamp instead of a flowing river. In addition to its powerful antioxidant actions, Proanthodyn also helps protect collagen and elastin, the main constituents of tissue in the capillaries, and throughout the body. It is absolutely essential for capillary walls — which are only one cell thick — to be strong and stable, so that they do not allow blood proteins to leak into the interstitial fluid. Once the interstitial fluid takes on a gel-like consistency, the surrounding cells literally become starved from lack of nutrition. The exciting news is that the proanthocyanidins contained in Proanthodyn are among the few substances yet discovered which can help strengthen capillary walls, ensuring the liquid nature of the interstitial fluid.2 Plus, proanthocyanidins help keep capillary and artery walls flexible, allowing for proper blood flow to the heart.
Heart Smarts
The 1990’s mark a decade of increased awareness among Americans of important health issues. Much of the discussion has revolved around protecting that precious center of life we call the heart. Simple lifestyle change is one of the most effective ways to maintain and protect the functioning of the cardiovascular system. In order to take a holistic approach to heart care, make sure you include plenty of fresh fruits and vegetables (organic, if possible) in your diet, and cut down on fatty and cholesterol-forming foods. Reduce your salt and alcohol intake to a minimum. Try to get regular, Sustained aerobic exercise for at least 30 minutes three times a week. Don’t smoke – or if you do smoke, try to eat even more fresh fruits and antioxidant-rich vegetables to counter the amount of free radicals being produced in your body. Lastly, consider adding Source Naturals HEART SCIENCE to your health regimen. HEART SCIENCE, the most comprehensive formula of its kind, provides targeted protection to the entire cardiovascular system. By approaching the promotion of normal heart function on five different levels — through the inclusion of ingredients which supply energy, decrease harmful homocysteine levels, fight cholesterol build-up, help regulate electrical rhythm, and protect artery and capillary linings — HEART SCIENCE is the perfect addition to a holistic approach to heart care.
Source Naturals HEART SCIENCE™
Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=155)
Date:
June 01, 2005 12:08 PM
It’s incredibly difficult to stay committed to a weight loss program—to change the eating habits of a lifetime and resist “emotional overeating.” You need a weight loss program that helps you break the unhealthful cycle of dieting and losing— followed by bingeing and gaining back.
DIET METABO-7 supports seven body systems related to successful weight loss, including cellular energy generation and metabolism, and neurotransmitter production to support calmness, drive and determination.
DIET METABO-7 SUPPORTS SEVEN BODY SYSTEMS
Your body is composed of complex interactive systems that work on many levels. Likewise, the nutrients in DIET METABO-7 target specific body systems and the connections between them. This full spectrum nutritional formula helps instill balance and harmony by addressing seven interrelated systems whose healthy function is necessary for successful dieting: the brain and nervous system, metabolic energy, liver, thyroid, blood sugar levels, adrenals and fluid balance.
MOOD MANAGEMENT: A POSITIVE ATTITUDE
DIET METABO-7 can help you change your habitual response to eating and start making healthy food choices. A key strategy involves the production of neurotransmitters, the brain chemicals that regulate your nervous system. When certain neurotransmitter levels are low in your brain, you may feel depressed. You crave simple carbohydrates and sugars from bread, pasta or candy— because when the brain is low in mood-enhancing neurotransmitters, it does whatever it can to increase them. It will cause you to crave those foods that produce the building blocks your body uses to raise those neurotransmitter levels. DIET METABO-7 provides specific vitamins and amino acids necessary for your brain to make norepinephrine, serotonin, dopamine and GABA, the major neurotransmitters that help regulate mood and attention, support clear focus and active calm, and affect drive and determination. Included are the amino acids tyrosine, glutamine, phenylalanine and GABA. For example, the brain uses phenylalanine and tyrosine to manufacture norepinephrine. Increased amounts of norepinephrine can block the drive to eat and may help provide a sense of well-being.
METABOLIC ACTIVATORS: HERBAL ENERGIZERS
To support a Sustained reduction of body fat, it’s helpful to increase metabolism via exercise and herbal stimulation while lowering caloric intake by curbing appetite. High doses of stimulants, however, are counterproductive and can make you nervous and irritable. To avoid being overly stimulative, DIETMETABO-7 is formulated with appropriate amounts of herbal metabolic activators that promote calorie burning and suppress appetite.
Used since ancient times in India to support health, Sida cordifolia contains a profile of naturally occurring ephedrine alkaloids that act as stimulants to promote the metabolism of fat. This thermogenic effect is augmented by the natural caffeine contained in standardized extracts of green tea, yerba mate, and kola nut. Also included are specific B vitamins essential to the production of energy from the breakdown of fats and carbohydrates.
HELPING THE LIVER: DETOXIFICATION AND CIRCULATION
One of the most overworked organs is the liver, the body’s chief manufacturing and detoxification plant. It constantly regulates the levels of chemicals circulating throughout the bloodstream and plays a key role in breaking down fat and eliminating waste products. The amino acid N-acetyl cysteine is an antioxidant that strongly supports liver function. Your liver needs it to make glutathione, a crucial detoxifying substance used to remove harmful compounds from your bloodstream. Optimal metabolic energy depends on healthy circulation, especially while dieting, when the bloodstream is delivering excess waste products to the liver for removal. To help maintain a healthy circulatory system, DIET METABO-7 includes standardized extracts of ginkgo and horse chestnut. In use for centuries, these botanicals have been the subject of numerous chemical and pharmacological investigations.
THE THYROID: YOUR BODY’S THERMOSTAT
Your thyroid gland produces hormones that control how quickly you burn calories and use energy. Tyrosine is an amino acid building block of thyroid hormones. Low blood levels of tyrosine have been associated with the underproduction of thyroid hormones. Kelp and bladderwrack provide natural sources of iodine, the basic substance of thyroid hormones.
STABILIZING BLOOD SUGAR: CONTROLLING MOOD SWINGS An important strategy of DIET METABO-7 is to minimize the changes in blood sugar levels that can cause unwanted mood swings, which diminish your physical and mental energy. Chromium, an essential mineral, is important to carbohydrate and fat metabolism and tends to increase insulin efficiency. It helps stabilize blood sugar levels and keep you on an even keel.
DEALING WITH THE STRESS FACTOR
Dieting often adds more stress to your life, and stress hormones affect the mind and body in many ways. They disrupt liver function and blood sugar levels, which lowers energy production in the brain, adversely influencing mood and motivation. Because your adrenals need extra attention, DIET METABO-7 helps nourish these hardworking glands with pantothenic acid and ascorbic acid, both necessary for healthy adrenal function. Also, pantothenic acid provides additional support for energy generation during dieting.
WATER BALANCE
Potassium is an essential mineral with many functions, including the transmission of electrical impulses in the brain. It works with sodium to control the body’s water balance. Dieting tends to deplete potassium levels in the body, therefore DIET METABO-7 replenishes this vital nutrient.
THE WEIGHT IS OVER
DIET METABO-7 provides necessary cofactors to balance body systems involved with healthy weight management. When used with the Maximum Metabolism Weight Loss Plan and exercise program, Source Naturals DIET METABO-7 may help you achieve your goal of a healthy and more vibrant life.
References
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=138)
Date:
May 30, 2005 10:11 AM
Can science meet the challenges of the HCV pandemic: new treatment options for chronic hepatitis C. Roehr B Journal of the International Association of Physicians in AIDS Care (1998 Jul), 4(7), 24-9. Journal code: 9508185. ISSN:1081-454X. United States. (NEWSPAPER ARTICLE) written in English. PubMed ID 11365638 AN 2001282246 MEDLINE
Abstract
New treatment options for chronic hepatitis C (HCV) infection are examined. Studies show the efficacy of interferon alfa-2b in normalization of serum alanine aminotransferase and histological improvement in necroinflammatory liver disease. However, 70 to 80 percent experiencing normalization usually relapse within 1 year after treatment. Ten to 20 percent will have a Sustained response lasting at least 3 years. Ideas for improving treatment response include longer initial treatment regimens, increasing dosages of interferon alpha, or adding another agent to interferon alpha. Based on encouraging study results, the interferon/ribavirin combination has been approved by the Food and Drug Administration (FDA) in HCV patients relapsing following interferon alpha monotherapy. So far the FDA has approved interferon alfa-2b, interferon alfa-2a, alfacon-1, and interferon alfa-2b/ribavirin as treatments for HCV; ribavirin alone is not effective against HCV infection. Other drugs are being tested with interferon alpha but have not generated enough substantive data. Thymosin, an immune modulator that enhances the body's production of interferon and interleukin rather than attacking HCV directly, is also being investigated. Oral dosing of interferon is in clinical trials for hepatitis B, and the results may be applicable to HCV. Alternative therapies are gaining wider interest such as using milk thistle for liver regeneration or using licorice root for quelling liver inflammation. As for transmission risk, there is little evidence supporting sexual activity as a major risk factor, however, some risk is reported with anal intercourse, sex during the menstrual cycles, and years of cohabitation with an infected partner.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=112)
Date:
May 12, 2005 12:39 PM
Garlic Elicits a Nitric Oxide-Dependent Relaxation and Inhibits Hypoxic Pulmonary Vasoconstriction in rats.
Author:
3. Acetylcholine (0.1 micromol/L)-induced NO-dependent relaxation was reduced from a control value of -76 +/- 1% to -46 +/- 4% during hypoxia and was further reduced to -35 +/- 2 % after reoxygenation.
5. Pretreatment with NG-nitro-L-arginine methyl ester abolished the early transient contraction, moderately attenuated the Sustained contraction and had no effect on the transient relaxation. Mechanical endothelial disruption inhibited all hypoxia-induced vascular changes.
7. Garlic also significantly inhibited endothelin-l-induced contractions in a dose-dependent manner.
8. These findings show that garlic extract modulates the production and function of both endothelium-derived relaxing and constricting factors and this may contribute to its protective effect against hypoxic pulmonary vasoconstriction.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=36)
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Leucine is one of 3 amino acids that increases muscle mass and will also help you to recover after exercise. Leucine supplies the body with energy and regulate blood sugar. Being an essential amino acids, it cannot be synthesized by the body and thus you need to get it from food or supplements. But Can L-Leucine help glucose metabolism and insulin function?
Importance of magnesium
Do you know what Cacao and some of its health benefits are?
Sometimes individuals can get a natural energy boost with bee pollen it is an option hat individuals can use to find and maintain a proper energy level. Bee pollen is an all natural product which has been used for a millenium. Energy boosts from pollen the can give individuals the energy boost they need. Pollen is a natural ways that individuals can get an energy lift. 
Guarana, scientifically named as Paullinia cupana is an evergreen vine indigenous to the northern regions of Brazil and Venezuela. Guarana berries are widely considered to be a great source of organic caffeine and also have been used for hundreds of years by native Amazonian tribes, the Guaranis to help retain their stamina levels and improve physical endurance. The natives believed that the drink made from this powdered ground seeds of the berries could provide more energy. They also claimed that, by drinking Guarana juice one could go on hunt for many days without food and also without feeling fatigue. 
Probiotics refer to a group of microorganisms that help maintain homeostasis in the digestive tract and even produce vitamins, minerals, and other nutrients. Nutrition experts have long recommended the consumptions of friendly bacteria as they curb the populations of harmful pathogens in the gut. More importantly, studies have shown that they contribute to the prevention of gastrointestinal disorders. 
Milk thistle has been used to treat liver problems for centuries. Its Latin name is Silybum marianum which explains the name of its main flavanoid complex, silymarin, which is obtained from the seeds. Milk thistle offers both a regenerative and a boosting effect to the liver, improving its effect on toxins while enabling it to recover from damage caused by cirrhosis, hepatitis and the effect of toxins and drugs. 
So if you take acetaminophen or drink alcohol on a regular basis, or you just want to protect your liver, what is stopping you from taking milk thistle? 
