Solaray S.O.D. 2000 Plus 100ct 400mg | Enteric Coated Antioxidant
Dual-Enzyme Primary Cellular Defense with Superoxide Dismutase & Catalase
Solaray S.O.D. 2000 Plus provides targeted daily protection against everyday cellular wear and tear. Your cells naturally produce antioxidant enzymes to protect tissues, joint cartilage, and blood vessels from cellular rust (oxidative stress). Solaray delivers a potent 400 mg enzyme complex featuring 2,000 McCord-Fridovich activity units of Superoxide Dismutase (S.O.D.) coupled with Catalase, safeguarded in acid-resistant, enteric-coated VegCaps to ensure these delicate proteins arrive intact where your body absorbs them.
Why Primary Enzymes Work Differently Than Regular Antioxidants
Most everyday supplements—such as Vitamin C, Vitamin E, or beta-carotene—are secondary dietary antioxidants. In simple terms, each molecule of a standard dietary antioxidant neutralizes only one single free radical before it is used up.
Superoxide Dismutase (S.O.D.) and Catalase are primary metabolic enzymes. Instead of being consumed in the reaction, they act as cellular workhorses that continuously neutralize free radicals round the clock. A single enzyme molecule can dismantle millions of free radicals every minute without being depleted.
The 2-Step Enzymatic Cascade:
Step 1 (Superoxide Dismutase): S.O.D. seeks out the aggressive superoxide radical (O2•−)—a common byproduct of energy production and UV light—and instantly converts it into oxygen and hydrogen peroxide (H2O2).
Step 2 (Catalase): While hydrogen peroxide is milder than superoxide, it still creates cellular stress if left alone. Catalase steps in immediately, breaking down hydrogen peroxide into pure water (H2O) and beneficial oxygen (O2).
Scientific Reference: In 1969, researchers J.M. McCord and I. Fridovich published the landmark discovery of enzymatic superoxide dismutation in the Journal of Biological Chemistry (McCord & Fridovich, 1969, 244(22): 6049–6055), establishing S.O.D. as the foundation of mammalian antioxidant defense.
Key Benefits of Enteric-Coated S.O.D. 2000 Plus
✓Acid-Resistant Enteric Protection: Enzymes are sensitive protein structures easily destroyed by harsh stomach acid. Solaray uses specialized enteric VegCaps that stay tightly sealed through stomach acidity and dissolve smoothly in the small intestine for maximum bioactivity.
✓Joint Comfort & Tissue Recovery: By buffering exercise-induced oxidative stress, S.O.D. helps maintain normal joint mobility, cartilage integrity, and muscle recovery after physical exertion.
✓Skin Cellular Health: S.O.D. protects against environmental stressors and photo-aging triggered by outdoor UV sunlight, helping sustain tissue firmness and healthy skin barrier function.
✓Microcirculation & Capillary Defense: Polyphenol-rich botanical extracts help support endothelial tone, balanced vascular circulation, and capillary resilience.
✓Phase II Liver Support: Formulated with pure Calcium D-Glucarate to assist the liver's natural glucuronidation pathway in escorting processed wastes safely out of the body.
Synergistic Botanical Support Base (70 mg)
Solaray strengthens this formula with a 70 mg synergistic botanical blend chosen to reinforce tissue protection and liver cleansing pathways:
Ingredient
Active Bioactives
How It Works in the Body
Rosemary Leaf (Rosmarinus officinalis)
Carnosic & Rosmarinic Acid
Protects fragile lipid membranes in brain and cardiovascular tissues from fat oxidation (peroxidation).
Green Tea Leaf Extract (Camellia sinensis)
Epigallocatechin Gallate (EGCG)
Provides broad-spectrum polyphenol activity that promotes cardiovascular lining health and cellular longevity.
Calcium D-Glucarate
D-Glucarate salts
Inhibits beta-glucuronidase, helping the liver complete glucuronidation to clear spent hormones and environmental toxins.
Ellagic Acid
Naturally occurring polyphenol
Supports healthy DNA structure and protects delicate cellular nuclei against mutagens and oxidative hits.
Grape Seed Extract (Vitis vinifera)
Oligomeric Proanthocyanidins (OPCs)
Reinforces collagen integrity, protects vein elasticity, and promotes healthy microcirculation in capillary beds.
Dietary Standards: Vegetarian / Vegan formulation, Lab Verified for purity and potency, Non-GMO.
Safety Information: Do not use if safety seal is broken or missing. Keep out of reach of children. Keep your licensed healthcare practitioner informed when using this product.
Usage Guidelines & Timing Instructions
Suggested Use: Use only as directed. Take 1 VegCap daily, an hour or more before meals or two hours after eating, with a full glass of water. As a dietary supplement, you may take 1 capsule up to three times daily an hour or more before meals, or as recommended by your qualified healthcare professional.
Why take S.O.D. on an empty stomach?
When you eat, your stomach releases proteolytic digestive enzymes (like pepsin) to digest food proteins. Taking S.O.D. at least 60 minutes before a meal ensures that stomach acid secretion remains calm, allowing the enteric capsule to pass quickly into the alkaline environment of the small intestine where enzymes are utilized efficiently.
Storage: Keep bottle tightly closed in a cool, dry place away from direct sunlight, excess heat, and humidity.
Clinical Evidence & Quality Standards
At VitaNet®, our team has guided customers through professional-grade enzyme supplementation for over three decades. Enzymatic nutrition requires strict adherence to biochemical realities—specifically enteric protection and activity unit standardization.
Enzyme Bioavailability & Delivery: Research evaluated by Vouldoukis et al. demonstrated that enteric microencapsulation of superoxide dismutase is necessary to bypass gastroduodenal degradation and elicit systemic antioxidant responses (Journal of Ethnopharmacology, 2004, 94(1): 67–75).
Glucuronidation Clearance: Calcium D-Glucarate is documented in clinical monographs for its capacity to downregulate elevated beta-glucuronidase activity, thereby preserving the Phase II detoxification pathway (Alternative Medicine Review, 2002, 7(4): 336–339).
Laboratory Potency Verification: Solaray subjects every production lot to comprehensive physical, chemical, and microbiological testing to verify that each capsule meets its labeled 2,000 McCord-Fridovich activity specification.
*Disclaimer: Statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult your qualified physician before beginning any dietary supplement program.
Frequently Asked Questions (FAQ)
What is Superoxide Dismutase (S.O.D.) and why do we need it?
Superoxide Dismutase is your body's frontline antioxidant enzyme. While typical dietary vitamins neutralize only one free radical apiece, S.O.D. continuously deactivates millions of superoxide radicals per minute. Supplementing helps replenish cellular enzyme levels that can drop with aging, strenuous exercise, and daily environmental exposure.
Why does Solaray S.O.D. 2000 Plus use an enteric coating?
Enzymes are delicate protein molecules. Without protection, ordinary gastric stomach acids and pepsin would break them down before they ever reached your circulation. Solaray uses enteric-coated vegetarian capsules that resist acidic stomach conditions, dissolving only when they reach the neutral small intestine to ensure optimal absorption.
Why are Superoxide Dismutase and Catalase formulated together?
They work together in a natural two-stage relay. When S.O.D. deactivates the dangerous superoxide radical, it converts it into hydrogen peroxide. Catalase immediately neutralizes that hydrogen peroxide into harmless water and oxygen, ensuring clean and complete radical clearance without intermediate byproduct accumulation.
How and when should I take S.O.D. 2000 Plus?
Take 1 VegCap daily with a full glass of water, either at least 1 hour before eating or 2 hours after a meal. Taking it on an empty stomach prevents digestive food enzymes from breaking down the active supplemental enzymes. For extra nutritional support, you may take 1 capsule up to three times daily an hour or more before meals.
Can Solaray S.O.D. 2000 Plus support skin health and outdoor exposure?
Yes. Many people working or exercising outdoors use S.O.D. to help mitigate free radical damage from ultraviolet (UV) sunlight. By protecting cellular lipids and collagen fibers from oxidative stress, S.O.D. and its accompanying botanical polyphenols help support skin elasticity and vitality from the inside out.
Helpful Customer Reviews
Review of S.O.D. 2000 Plus - Solaray Product 8930 Reviewed by Eric Michael
Wednesday, May 11, 2011 Rating: 5/5
I was always told that you will have to pay the doctor or the farmer for your health. Now that I have four children and a career to juggle I don't have time for either. Supplements have been a health saver for my family and S.O.D. 2000 Plus is now a key component.
I manage landscaping crews in the Texas sun so antioxidants are a must.
”The amount of antioxidants in your body is directly proportional to how long you will live."
- Dr. Richard Cutler, former Director of the National Institute of Aging, Washington
I have been taking 1-2000 MG of vitimain C for years to help reduce the suns damage to my skin; now I have S.O.D. 2000 Plus to fight the inner battle against those same "free radicals" that are attacking my cells from the inside.
Another great product from Solaray! I recommend SOD to anyone concerned with fighting free radicals.
