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- $38.28
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- UPC: 733739000736
- # N0073
NOW Foods L-Carnitine 500 mg Veg Capsules (Carnipure®)
Fueling your body at the cellular level requires efficient energy transport. NOW Foods L-Carnitine 500 mg provides a clinically validated, highly absorbable form of this vital amino acid derivative to support active cellular energy, fatty acid metabolism, and muscular endurance. Formulated with trademarked Carnipure® L-Carnitine Tartrate, this premium supplement offers 100% pure L-isomer carnitine, completely free of unwanted synthetic D-carnitine byproducts.
In plain terms, think of your cells as tiny combustion engines. Fats are one of the cleanest fuels your body can burn, but they cannot enter the cellular "burn chamber" (the mitochondria) on their own. L-Carnitine acts as the essential shuttle ferry that loads up these fatty acids from your bloodstream and carries them straight into your cell powerhouses to be converted into clean, usable ATP energy.
- ✓ 500 mg Pure Active L-Carnitine: Delivered from 746 mg of stabilized, pharmaceutical-grade L-Carnitine Tartrate.
- ✓ Clinically Tested Carnipure®: Patented Swiss-formulated carnitine guaranteed to deliver zero inactive D-isomers.
- ✓ Dual Action Support: Stimulates mitochondrial fatty acid oxidation while buffering metabolic waste during exercise.
- ✓ 100% Vegetarian & Vegan: Non-animal microbial fermentation encased in plant-derived hypromellose capsules.
- ✓ Clean Label Verified: Non-GMO, gluten-free, dairy-free, soy-free, Kosher (Triangle K), and Halal certified.
How It Works: The Mitochondrial "Carnitine Shuttle" Explained
To understand why L-carnitine is essential for both daily vitality and athletic conditioning, it helps to examine human cellular biochemistry. Long-chain fatty acids represent the body's primary energy reserve. However, the inner mitochondrial membrane is naturally impermeable to fatty molecules. Without an active transport mechanism, fatty acids remain stranded in the cytosol, unable to generate cellular energy (adenosine triphosphate, or ATP).
L-Carnitine operates through a highly specialized four-step enzymatic system known as the Carnitine Shuttle:
- Esterification (CPT-1): On the outer mitochondrial boundary, the enzyme Carnitine Palmitoyltransferase-1 (CPT-1) binds free L-carnitine to long-chain fatty acyl-CoA molecules, transforming them into acylcarnitine.
- Translocation (CACT): A dedicated gateway transporter, Carnitine-Acylcarnitine Translocase (CACT), ferries the acylcarnitine across the impenetrable inner mitochondrial barrier.
- Release & Beta-Oxidation (CPT-2): Inside the mitochondrial matrix, Carnitine Palmitoyltransferase-2 (CPT-2) uncouples the fatty acid from carnitine. The freed fatty acid immediately undergoes beta-oxidation and enters the Krebs cycle to produce massive amounts of ATP.
- Recycling: The free carnitine molecule is shuttled back across the membrane by CACT, ready to pick up another fatty acid passenger.
Beyond ferrying fats, supplemental L-carnitine acts as an intracellular buffer for Coenzyme A (CoA). When muscle fibers experience intense exertion, acetyl groups accumulate rapidly. L-Carnitine binds these excess acetyl groups to form acetylcarnitine, freeing up unbound CoA. This metabolic buffering prevents cellular acidosis, delays muscle exhaustion, and accelerates post-training recovery.
Authoritative Clinical References:• Sharma, S., et al. (2022). "The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Disease." Nutrients, 14(5): 960. [PMID: 35267986]
• Longo, N., et al. (2016). "Carnitine Transport and Fatty Acid Oxidation." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1863(10): 2422–2435. [PMID: 26828774]
• Fielding, R., et al. (2018). "l-Carnitine Supplementation in Recovery after Exercise." Nutrients, 10(3): 349. [PMID: 29534432]
• Stefan, M., et al. (2021). "L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial." Nutrients, 13(10): 3432. [PMID: 34684433]
Supplement Facts & Complete Ingredient Verification
VitaNet verifies every label against the manufacturer's active batch records. Pure free-form L-carnitine base is naturally hygroscopic, meaning it absorbs moisture from ambient air rapidly, leading to clumping and chemical breakdown. NOW Foods stabilizes this formula by binding pure L-carnitine to USP-grade L-tartaric acid, yielding a resilient crystal salt (L-Carnitine L-Tartrate) that resists humidity, dissolves effortlessly, and releases fast in the digestive tract.
| Nutrient / Active Component | Amount Per 1 Veg Capsule | % Daily Value |
|---|---|---|
| L-Carnitine (Carnipure®) (from 746 mg L-Carnitine Tartrate) |
500 mg | ** Daily Value not established |
| Serving Size | 1 Veg Capsule | |
| Servings Per Container | 180 Servings (SKU: 0073 / VitaNet: N0073) | |
Full Other Ingredients:
Hypromellose (vegetarian cellulose capsule), Stearic Acid (vegetable source), and Silicon Dioxide. (May also contain Microcrystalline Cellulose and Magnesium Stearate [vegetable source] across select certified production runs).
Allergen & Purity Profile:
Free of Common Allergens: Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut, or sesame ingredients. Produced in an audited, third-party certified GMP facility that adheres strictly to allergen control programs to eliminate cross-contamination.
NOW Foods Lab Purity: World-Class ISO 17025 Testing & Strict Contaminant Standards
The dietary supplement sector faces widespread challenges with underdosing, heavy metal accumulation, and unverified foreign raw materials. NOW Foods neutralizes these risks by investing in one of the most advanced analytical private testing networks in North America. Conducting over 19,000 to 31,000 comprehensive tests each month, NOW validates incoming raw ingredients, in-process blends, and finished encapsulated products across state-of-the-art facilities in Bloomingdale, Illinois, and Sparks, Nevada.
To guarantee clinical efficacy and consumer safety, NOW subjects its L-Carnitine to uncompromising pharmaceutical-grade testing protocols:
- • Optical Isomer Purity via HPLC: Carnitine exists in two optical mirror images: L-carnitine and D-carnitine. D-Carnitine is biologically toxic, directly competing with and inhibiting normal L-carnitine cellular transport, which can lead to muscle weakness and depletion. NOW uses High-Performance Liquid Chromatography (HPLC) to verify 100% optical purity of the active L-isomer, guaranteeing zero detectable D-carnitine contamination.
- • ICP-MS Heavy Metal Screening: Utilizing Inductively Coupled Plasma-Mass Spectrometry (ICP-MS), NOW chemists detect elemental contaminants down to parts per billion (ppb). Every batch is screened to satisfy rigid United States Pharmacopeia (USP <2232>) limits and California Proposition 65 constraints for Lead (<0.5 mcg/day), Arsenic, Cadmium, and Mercury.
- • LC-QTOF-MS Adulteration Defense: Through Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-QTOF-MS), NOW runs untargeted High-Resolution Accurate-Mass (HRAM) screens to uncover undisclosed synthetic adulterants, counterfeit amino acids, and chemical residues.
- • Pesticide & Glyphosate Residue Analysis: Advanced GC-MS/MS, LC-MS/MS, and dedicated Ion Chromatography-Tandem Mass Spectrometry (IC-MS/MS) test for hundreds of common agricultural chemicals, verifying non-detectable levels of glyphosate down to parts-per-billion sensitivity.
- • Full Pathogen Microbiological Clearance: Complete screening in ISO-accredited microbiology suites confirms the total absence of Salmonella spp., Escherichia coli, and Staphylococcus aureus, alongside strict thresholds for aerobic plate counts, yeast, and mold.
NOW's quality operations maintain accredited ISO/IEC 17025:2017 status, Underwriters Laboratories (UL) cGMP registration, and Intertek GMP Supplement Certification. NOW also acts as an industry watchdog, routinely purchasing competitor products from e-commerce discount marketplaces and publishing independent lab analyses that uncover widespread adulteration and fraudulent label claims.
Usage Guidelines, Synergistic Stacking & Crucial Precautions
Suggested Daily Intake: As a dietary supplement, take 1 veg capsule 1 to 3 times daily.
Timing for Exercise & Performance: On training days, take 1 capsule 30 to 60 minutes prior to exercise to elevate plasma carnitine levels during peak fat-burning demands, or take 1 capsule immediately post-workout with a meal. Human clinical trials demonstrate that muscle retention of L-carnitine is heavily enhanced when co-ingested with carbohydrates or a balanced meal, because the organic cation transporter novel 2 (OCTN2) responsible for carnitine uptake into muscle cells is stimulated by insulin (Wall et al., J Physiol, 2011; 589:963–973).
Synergistic Nutritional Stacks:
- Coenzyme Q10 (CoQ10 / Ubiquinol): While L-carnitine delivers fatty acids into the mitochondria, CoQ10 transfers electrons within the electron transport chain to generate ATP, making them natural biological partners for cardiovascular and physical vitality.
- Pantethine (Vitamin B5 Precursor): Pantethine provides the active building block for Coenzyme A (CoA), directly supporting the carnitine palmitoyltransferase enzyme network.
- Alpha Lipoic Acid (ALA): Provides potent mitochondrial antioxidant defense against the free radicals naturally generated during high-intensity aerobic exercise.
Important Health Precautions & Clinical Contraindications:
Thyroid Conditions: L-Carnitine acts as a peripheral antagonist to thyroid hormone action. Research demonstrates that carnitine inhibits both triiodothyronine (T3) and thyroxine (T4) nuclear entry (Benvenga et al., Ann N Y Acad Sci, 2004; 1033:158–167). If you have hypothyroidism, Hashimoto's thyroiditis, or are currently taking thyroid hormone replacement therapy (such as levothyroxine), consult your physician before use.
Seizure Disorders: High supplemental doses of carnitine have been reported to increase the risk or frequency of seizures in patients with diagnosed seizure disorders or epilepsy.
General Safety: For adults only. Consult a licensed physician if pregnant, nursing, taking anticoagulant medications (such as warfarin), or managing a chronic medical condition. Keep tightly sealed in a cool, dry place out of reach of children.
Why Buy NOW Foods L-Carnitine From VitaNet®, LLC?
Where you purchase your supplements directly affects their freshness, potency, and safety. Mass e-commerce platforms allow thousands of anonymous third-party resellers to store delicate nutritional supplements in unconditioned, sweltering warehouses for months, degrading active ingredients before they ever reach your doorstep.
VitaNet®, LLC has served health-conscious shoppers as an independent, family-owned American retailer online since 1995[cite: 1]. Backed by over 31 years of dedicated hands-on industry experience and natural health expertise, we treat our customers like family[cite: 1]:
- ✓ Unconditional 100% Money-Back Guarantee: We stand behind every product we sell[cite: 1]. If you are not satisfied for any reason, VitaNet covers your refund and even pays the return shipping costs, even on opened bottles[cite: 1].
- ✓ Factory-Direct Freshness: We partner directly with authorized distributors and manufacturers, cycling inventory continuously to guarantee long expiration dates and peak biological activity[cite: 1].
- ✓ Climate-Controlled Storage: All vitamins are housed in clean, temperature-regulated facilities to shield amino acid bonds from thermal and humidity degradation[cite: 1].
- ✓ BBB A+ Accredited Business: VitaNet proudly maintains the highest A+ rating with the Better Business Bureau for transparent business practices and customer-first care[cite: 1].
- ✓ Real Human Support: Have questions about your supplement routine? Call our physical storefront at 887 Edison Street Northwest in Hartville, Ohio at (330) 877-8786 to speak with real natural wellness specialists[cite: 1].
Frequently Asked Questions (FAQ)
1. What is the difference between L-Carnitine and Acetyl-L-Carnitine (ALCAR)?
Standard L-Carnitine (especially in the L-Tartrate form found here) is primarily utilized by peripheral tissues like skeletal muscle and the heart to shuttle long-chain fatty acids into mitochondria for physical energy and workout recovery. Acetyl-L-Carnitine (ALCAR) features an added acetyl group that allows it to cross the blood-brain barrier easily, where it is preferentially used to support cognitive function, neurotransmitter synthesis (acetylcholine), and brain health.
2. Why is L-Carnitine bound to Tartrate in this formula?
Pure unbonded L-carnitine powder is highly hygroscopic, meaning it rapidly attracts ambient moisture, causing clumping and premature degradation. By bonding L-carnitine to natural L-tartaric acid (forming L-Carnitine L-Tartrate), Lonza creates Carnipure®, a chemically stable crystal that resists moisture and provides rapid, reliable absorption in the human digestive system.
