NOW D-Mannose 500 mg (240 Veg Capsules)

Cleanse the Bladder & Support a Healthy Urinary Tract

NOW Foods D-Mannose 500 mg delivers pure, targeted nutritional support to help cleanse the urinary tract and protect the natural lining of your bladder. D-mannose is a simple, naturally occurring sugar that your body absorbs quickly but barely burns for fuel, allowing it to pass directly into your urine to flush away unwanted impurities. Free from artificial fillers, this vegetarian formula offers a gentle, non-acidic way to maintain everyday urinary comfort without added table sugars or sour juices.

Quick Specs Snapshot

• ✓ Active Form & Potency: 1,500 mg of pure, non-GMO D-mannose per 3 vegetarian capsules (500 mg per capsule).
• ✓ Primary Cellular Target: Bladder lining (urothelium) and urinary tract mucosa.
• ✓ Supply & Value Math: 80 complete servings (240 capsules total) per bottle, providing up to an 80-day supply of daily maintenance.
• ✓ Formulation Purity: 100% vegan, non-GMO, and free of gluten, soy, dairy, yeast, wheat, nuts, and artificial preservatives.

"Right-Fit" Buyer's Guide & Form Comparison

Why the Form Matters

Pure D-mannose provides direct, concentrated cleansing action that works faster and more effectively than standard cranberry pills or cranberry juice cocktails alone [1]. Many commercial cranberry drinks are packed with added sugars or harsh acids that can irritate a sensitive stomach and bladder, while standard cranberry pills rely on proanthocyanidins that take longer to build up in your system [1, 2]. Pure crystalline D-mannose filters rapidly through your kidneys into your urine without interfering with healthy blood sugar balance or digestive tolerance [1, 3].

Is This Formula Right for You?

Ideal For Shoppers Who:

• ✓ Want a natural, dependable way to keep their bladder and urinary tract clean and comfortable [1].
• ✓ Prefer swallowable, taste-free vegetarian capsules over sour cranberry juices or acidic supplements.
• ✓ Want an economical, family-sized bottle (240 capsules) that provides flexible dosing for daily defense or short-term intensive cleansing.

Consider Another Option If:

• ✗ You have difficulty swallowing capsules (a pure bulk D-mannose powder stirred into water may be easier to take).
• ✗ You are experiencing an acute medical infection with fever, chills, or back pain (these symptoms require direct medical care from a physician, not a dietary supplement).
• ✗ You are looking for a multi-herb complex that includes harsh botanical diuretics like uva ursi or juniper berry.

Risk-Free Assurance: Every purchase at VitaNet®, LLC is backed by our unconditional 100% money-back guarantee—which even covers return shipping on opened bottles—so you can evaluate this formula with complete confidence[cite: 1].

How D-Mannose Works: Biochemical Mechanisms & Cellular Pathways

To understand how D-mannose works, imagine tiny Velcro hooks. Unwanted microorganisms in the urinary tract (such as Escherichia coli) have microscopic hair-like projections tipped with proteins called FimH adhesins [4]. In a normal bladder, these tiny hooks grab onto natural mannose sugars that coat your bladder wall, allowing them to cling tightly to the tissue [4].

1. The Molecular Decoy Action

Chemically, D-mannose is a six-carbon sugar with the molecular formula C₆H₁₂O₆. Even though it shares the same chemical formula as glucose, your body metabolizes very little of it [2, 3]. After you swallow a capsule, D-mannose is quickly absorbed in your upper digestive tract, enters the bloodstream, and travels straight to your kidneys without being converted into energy or glycogen [2, 3].

2. Free-Flowing Cleansing

Your kidneys filter D-mannose directly into your urine, flooding your bladder with free-floating mannose molecules [1, 2]. When bacteria attempt to latch onto the bladder lining, they are tricked into grabbing the abundant floating D-mannose instead [1, 4]. Once their hooks are occupied, they can no longer stick to the bladder wall. When you urinate, the bound bacteria are simply flushed out of your body naturally with the flow of water [1, 4].

Scientific References

1. Kranjčec B, Papeš D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World Journal of Urology, 2014, 32(1): 79-84.
2. Domenici L, Monti M, Bracchi C, et al. D-mannose: a promising support for acute urinary tract infections in women. A pilot study. European Review for Medical and Pharmacological Sciences, 2016, 20(13): 2920-2925.
3. Porru D, Parmigiani A, Tinelli C, et al. Oral D-mannose in recurrent urinary tract infections in women: a pilot study. Journal of Clinical Urology, 2014, 7(3): 208-213.
4. Ofek I, Goldhar J, Eshdat Y, Sharon N. The importance of mannose-specific adhesins (lectins) in infections caused by Escherichia coli. Scandinavian Journal of Infectious Diseases, 1982, 33: 61-67.

Practical Dosing, Timing & Daily Synergy Protocol

Optimal Timing & Meal Pairing

Take 3 veg capsules 1 to 3 times daily with a full 8-ounce glass of pure water. Because D-mannose is completely water-soluble, it does not require dietary fat for absorption. You can take it on an empty stomach or with a light snack. Drink plenty of water throughout the day to support regular bladder emptying and healthy urinary flow [1].

Circadian & Split-Dosing Strategy

For general daily maintenance, take 3 capsules once per day in the morning. For active or periodic support, split your intake into 3 capsules taken two to three times throughout the day (such as morning, mid-afternoon, and before bedtime). Taking a serving right before bed is particularly helpful because urine stays in the bladder longer overnight, giving D-mannose extended contact time to protect the bladder lining [1, 3].

Smart Synergies & Spacing Rules

What Pairs Well: D-mannose works synergistically with whole cranberry fruit concentrates (which supply complementary proanthocyanidins) and targeted probiotics like Lactobacillus rhamnosus to promote healthy vaginal and urinary microflora balance.

What to Avoid: Avoid taking D-mannose alongside high-sugar fruit punches or sodas, as excess sugar can feed unwanted microbes. If taking activated charcoal or binder supplements, space them at least 2 hours apart so they do not trap the D-mannose molecules before absorption.

Timeline of Expectations

• ✓ Week 1: Rapid urinary clearance begins within hours of your first serving as D-mannose filters into the bladder to support soothing comfort [2].
• ✓ Weeks 3–4: Ongoing daily cleansing helps maintain a clean, resilient bladder lining and promotes consistent day-to-day comfort [1, 3].
• ✓ Months 2–3+: Long-term urinary tract wellness and sustained peace of mind, helping you stay ahead of recurring discomfort [1].

Physical, Sensory & Clean Excipient Profile

Delivery Format & Swallowability

This formula is delivered in standard two-piece vegetarian "0" capsules. The smooth plant cellulose shell becomes slippery when wet, allowing each capsule to slide down easily with a sip of water. There is zero aftertaste and none of the mouth-puckering sourness associated with cranberry extracts.

Natural Aroma, Taste & Color Notes

Inside each capsule is a pure white-to-off-white crystalline powder. It has virtually no scent. If you open a capsule into water, it dissolves cleanly and leaves a very mild, pleasantly sweet taste. Natural color variation between batches is normal and reflects authentic raw material sourcing.

Other Ingredients Demystified

Every added ingredient serves a clear, functional purpose to protect product stability and ensure precise filling:

• • Hypromellose (cellulose capsule): A vegetarian capsule shell derived from natural plant fibers, completely free of animal gelatin.
• • Rice Flour: A gentle, hypoallergenic grain flour used to fill empty space and ensure each capsule contains an exact 500 mg dose.
• • Stearic Acid (vegetable source): A natural plant-based fatty acid that helps the powder blend smoothly during manufacturing.
• • Magnesium Stearate (vegetable source): A plant-derived mineral salt that prevents raw powder from sticking to encapsulating machines.
• • Silicon Dioxide: A natural mineral compound (derived from sand and quartz) that absorbs ambient moisture to stop powder from caking inside the bottle.

Storage & Packaging

Store in a cool, dry place after opening. Keep the lid sealed tightly to protect the hygroscopic D-mannose crystals from bathroom humidity. This bottle is proudly manufactured from 100% post-consumer recycled (PCR) resin to reduce environmental plastic waste.

Supplement Facts & Retailer Verification

Supplement Facts

Serving Size: 3 Veg Capsules

Servings Per Container: 80

** Percent Daily Values are based on a 2,000 calorie diet.

† Daily Value not established.