- UPC: 733739032676
- # N3267
Clinically Studied Antioxidant & Endothelial Circulation Support
NOW® Pycnogenol® 100 mg supplies an evidence-based concentration of patented French maritime pine bark extract, one of nature's most extensively researched botanical compounds. Derived exclusively from sustainably managed pine forests along the southwestern coast of France (Les Landes de Gascogne), Pycnogenol® provides a standardized, bioavailable blend of water-soluble proanthocyanidins, bioflavonoids, and organic phenolic acids.
Unlike standard pine bark extracts, genuine Pycnogenol® is backed by more than 40 years of scientific research, 160 clinical trials, and over 450 published studies validating its ability to protect cell structures from oxidative stress, encourage normal nitric oxide production, and support comprehensive vascular and microcirculatory health.
Evidence-Based Mechanisms & Physiological Benefits
1. Vascular Function & Microcirculation Support
Pycnogenol® enhances endothelial nitric oxide synthase (eNOS), the key enzyme responsible for producing nitric oxide (NO) within vascular linings. Optimal nitric oxide levels promote endothelial relaxation, supporting healthy blood vessel dilation, smooth venous blood flow, healthy blood pressure already within a normal range, and microcirculation to the extremities, eyes, and brain.
2. Collagen Synthesis & Joint Tissue Maintenance
Procyanidins selectively bind to collagen and elastin fibers, shielding connective tissues from enzymatic degradation caused by matrix metalloproteinases (MMPs) and elastase. This mechanism helps preserve cartilage matrix integrity, promotes comfortable joint mobility, and maintains structural support across delicate joint, skin, and vascular tissues.
By promoting hyaluronic acid and collagen synthesis while neutralizing free radicals generated by environmental exposure and UV stress, Pycnogenol® supports dermal hydration, skin elasticity, and a smoother skin appearance from within.