SOURCE NATURALS: Inflama Rest 60 tabs

Inflama Rest - 60 tabs



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UPC: 021078015789
# SN1578

Source Naturals Inflama-Rest™ — Bio-Aligned Formula® for Healthy Inflammatory Response & Joint Comfort

Item Code: SN1578 | UPC: 021078015789 | Size: 60 Tablets

Source Naturals Inflama-Rest™ is an advanced, multi-system botanical and nutrient complex engineered to address the biochemical root triggers of musculoskeletal discomfort. Unlike single-ingredient pain formulations, Inflama-Rest’s proprietary Bio-Aligned Formula® simultaneously targets the body’s primary inflammatory cascades: regulating the Cyclooxygenase-2 (COX-2) and 5-Lipoxygenase (5-LOX) enzyme pathways, modulating Nuclear Factor-kappa B (NF-?B) transcription, quenching inducible Nitric Oxide Synthase (iNOS), and mitigating free radical damage to connective cartilage and muscle tissue.

The Science of Balanced Inflammation: How Inflama-Rest™ Works

Acute inflammation is the body’s essential physiological defense mechanism following physical exertion or tissue injury. However, when the pro-inflammatory signaling cascade is sustained or dysregulated, chemical messengers can degrade joint cartilage, promote persistent synovial irritation, and cause prolonged muscular stiffness. Standard over-the-counter interventions often create systemic imbalances by isolating a single pathway (such as non-selective COX inhibition), which can compromise gastrointestinal integrity and renal microcirculation. Source Naturals Inflama-Rest™ delivers a synergistic matrix of standardized botanical extracts, proteolytic enzymes, adaptogens, and trace mineral cofactors that modulate inflammatory signaling at multiple control checkpoints without blunting the body’s innate healing response.

1. Dual Inhibition of COX-2 & 5-LOX Cascades

Arachidonic acid is metabolized via two primary pathways: Cyclooxygenase (COX), which generates prostaglandins and thromboxanes, and 5-Lipoxygenase (5-LOX), which produces pro-inflammatory leukotrienes (notably LTB4). By combining Humulex™ Hops Cone Extract (Perluxan™), high-potency Turmeric Root Extract (95% curcuminoids), and Boswellia Gum Resin Extract (65% boswellic acids), Inflama-Rest provides dual pathway balance. Inhibiting both COX-2 and 5-LOX prevents the "shunting" phenomenon—wherein blocking COX alone pushes arachidonic acid toward excess leukotriene synthesis.

2. Nuclear Factor-Kappa B (NF-?B) Modulation

NF-?B serves as the master cellular switch that transcribes pro-inflammatory cytokines, including Tumor Necrosis Factor-alpha (TNF-a), Interleukin-1 beta (IL-1ß), and Interleukin-6 (IL-6). Standardized polyphenols—including trans-Resveratrol, Green Tea EGCG, and Quercetin—inhibit I?B kinase (IKK) activation, keeping NF-?B dormant in the cytoplasm and curbing the downstream transcription of inflammatory proteins.

3. Fibrin Degradation & Proteolytic Cleavage

Tissue recovery requires the clearing of inflammatory debris and micro-clots. Inflama-Rest incorporates enteric proteolytic enzymes, including Bromelain (2,000 G.D.U./g) and pure fermented Nattokinase (NSK-SD™). These systemic enzymes break down excess cross-linked fibrin fibers, degrade circulating immune complexes, and support healthy lymphatic flow to swollen joints.

4. Neuroendocrine & Muscle Tension Support

Physical stress stimulates the hypothalamic-pituitary-adrenal (HPA) axis, elevating cortisol and inducing skeletal muscle tension. Inflama-Rest integrates premium Ayurvedic adaptogens—Ashwagandha Root Extract and Holy Basil Leaf Extract—alongside bioavailable Magnesium to calm hyperactive neuromuscular junctions and support muscle relaxation.

Complete Supplement Facts & Standardized Actives

Every 4-tablet daily serving of Source Naturals Inflama-Rest™ delivers clinically meaningful dosages of authenticated, standardized plant constituents, active enzymes, and essential micronutrients.
Ingredient / Nutrient Component Amount Per Serving (4 Tablets) % Daily Value (%DV)
Calories 10 —
Total Carbohydrate 2 g 1%*
Dietary Fiber 1 g 4%*
Vitamin D-3 (as cholecalciferol) 62.5 mcg (2,500 IU) 125%
Magnesium (as magnesium oxide, succinate, & amino acid complex) 300 mg 71%
Zinc (as zinc methionine sulfate complex [OptiZinc®]) 5 mg 45%
Selenium (as L-selenomethionine & sodium selenite) 100 mcg 181%
Manganese (as manganese citrate) 5 mg 217%
Sodium 20 mg 1%
Standardized Botanical & Enzyme Complex
Turmeric Root Extract (Standardized to 95% Curcuminoids) 1.05 g (1,050 mg) †
Ginger Root (Whole powdered root) 600 mg †
Hops Cone Extract (Perluxan™ / yielding 90 mg Humulex™ alpha-acids) 300 mg †
Chinese Skullcap Root Extract (Scutellaria baicalensis) 250 mg †
Boswellia Gum Resin Extract (Standardized to 65% boswellic & organic acids) 250 mg †
trans-Resveratrol (from Polygonum cuspidatum root extract) 250 mg †
Bromelain (2,000 Gelatin Digesting Units [G.D.U.] per gram) 250 mg †
Ginger Rhizome Extract (Standardized to 5% gingerols) 200 mg †
Holy Basil Leaf Extract (Ocimum sanctum / Tulsi) 150 mg †
Oregon Grape Root (Mahonia aquifolium / source of berberine) 120 mg †
Green Tea Leaf Extract (Rich in EGCG polyphenols) 100 mg †
Ashwagandha Root Extract (Withania somnifera) 100 mg †
Quercetin (Dihydrate flavonoid) 90 mg †
Silymarin (from Milk Thistle Seed Extract) 80 mg †
Willow Bark Extract (Standardized salicin source) 80 mg †
Feverfew Aerial Parts Extract (Tanacetum parthenium) 75 mg †
Stinging Nettle Leaf (Urtica dioica) 60 mg †
Rosemary Leaf Extract (Rosmarinus officinalis) 50 mg †
Black Pepper Fruit Extract (BioPerine® / 95% piperine) 15 mg †
Nattokinase (NSK-SD™ / Fermented soybean extract) 12 mg †
Tocotrienol Complex (EVNolMax™ / Full-spectrum tocotrienols) 10 mg †

* Percent Daily Values (%DV) are based on a 2,000-calorie diet. † Daily Value (DV) not established. Other Ingredients: Modified cellulose gum, stearic acid, acacia gum, and silica. Allergen Notice: Contains soy (from Nattokinase NSK-SD™).

Deep-Dive: Key Bioactive Ingredients & Standardizations

Curcuminoids (95% Extract - 1,050 mg) + BioPerine® (15 mg):
Curcumin is a premier botanical for joint comfort, but standard oral curcumin has notoriously low bioavailability due to rapid phase-II hepatic glucuronidation. Inflama-Rest pairs a robust 1.05-gram dose of 95% standardized curcuminoids with 15 mg of patented BioPerine® black pepper extract. Clinical trials demonstrate that piperine inhibits intestinal and hepatic glucuronidation, amplifying curcumin bioavailability by up to 2,000% to ensure active compounds reach target synovial tissues.
Hops Cone Extract (Perluxan™ / 90 mg Humulex™ alpha-acids):
Perluxan™ is a proprietary extract of hops cones (Humulus lupulus L.) standardized to pure alpha-acids. In human double-blind trials, Perluxan™ selectively suppresses COX-2-mediated prostaglandin E2 (PGE2) without inhibiting COX-1 (the constitutive enzyme responsible for protecting the stomach lining). Clinical evaluations confirm significant improvements in joint comfort and mobility within two hours of administration.
Boswellia serrata Gum Resin (65% Boswellic Acids - 250 mg):
Boswellic acids—specifically 3-O-acetyl-11-keto-beta-boswellic acid (AKBA)—act as direct, non-redox, non-competitive inhibitors of 5-lipoxygenase (5-LOX). By shutting down leukotriene generation, Boswellia prevents inflammatory leukocyte infiltration into synovial joint cavities, preserving cartilage proteoglycans against enzymatic degradation.
OptiZinc® & Manganese Citrate:
Zinc monomethionine (OptiZinc®) resists absorption interference from dietary fibers and phytates, serving as an obligate cofactor for Superoxide Dismutase (Cu/Zn-SOD). Manganese citrate supplies the core mineral required by glycosyltransferase enzymes for the synthesis of chondroitin sulfate and hyaluronic acid in cartilage tissue.

Peer-Reviewed Scientific Evidence & Citations

The ingredients in Source Naturals Inflama-Rest™ have been validated across decades of peer-reviewed clinical, pharmacological, and biochemical research:

Dosage Instructions & Retail Specialist Recommendations

To achieve the highest absorption and clinical efficacy from Source Naturals Inflama-Rest™, follow these administration protocols developed by our supplement specialists:

Safety Information, Contraindications & Precautions

Please review the following health advisories before beginning Inflama-Rest™:

Frequently Asked Questions (FAQ) about Source Naturals Inflama-Rest™

What makes Source Naturals Inflama-Rest™ different from standard turmeric or joint supplements?

Most joint supplements solely supply glucosamine or standard non-standardized turmeric powder. Inflama-Rest™ is a comprehensive Bio-Aligned Formula® engineered to target four distinct biochemical pathways simultaneously: COX-2 inhibition, 5-LOX leukotriene suppression, NF-?B cytokine downregulation, and proteolytic fibrin clearance. It combines 95% standardized curcuminoids enhanced by BioPerine® with clinically validated Perluxan™ hops alpha-acids, AKBA-rich Boswellia, adaptogens (Ashwagandha and Holy Basil), and systemic enzymes (Bromelain and Nattokinase) for whole-body musculoskeletal comfort.

How long does it take for Inflama-Rest™ to start providing joint and muscle relief?

Individual response times vary depending on the severity of discomfort and baseline nutritional status. However, fast-acting components like Perluxan™ hops cone extract have been demonstrated in clinical studies to support joint comfort within 2 hours of ingestion. For deep, systemic modulation of NF-?B pathways and tissue regeneration, consistent daily supplementation over 2 to 4 weeks (preferably utilizing the 4 tablets twice-daily loading dose) is recommended.

Can I take Inflama-Rest™ instead of ibuprofen or other over-the-counter NSAIDs?

Inflama-Rest™ is a dietary supplement designed to support a healthy inflammatory response; it is not an FDA-approved drug intended to diagnose, treat, cure, or replace pharmaceutical NSAIDs. However, many individuals choose Inflama-Rest because its botanical extracts (notably Perluxan™ and Boswellia) selectively modulate COX-2 and 5-LOX without shutting down COX-1, making it substantially gentler on the gastric mucosal barrier than conventional non-steroidal anti-inflammatory drugs. Never discontinue prescription medications without consulting your physician.

Does Inflama-Rest cause stomach upset like aspirin or ibuprofen?

Conventional NSAIDs frequently cause stomach irritation because they inhibit both COX-1 (the protective enzyme maintaining the stomach lining) and COX-2. Inflama-Rest’s primary botanicals, such as Perluxan™ hops extract and Boswellia serrata, are naturally selective for COX-2 and 5-LOX, leaving COX-1 intact. Additionally, soothing herbs like ginger rhizome help buffer gastric tissue. Because this formula contains active botanicals and digestive enzymes, taking the tablets with a full meal eliminates gastrointestinal discomfort for the vast majority of users.

Can I take Inflama-Rest if I am on blood thinners or aspirin?

If you are taking prescription blood thinners (such as Warfarin, Eliquis, or Xarelto), antiplatelet drugs (Plavix), or high-dose daily aspirin, you must consult your physician or pharmacist prior to taking Inflama-Rest. This supplement contains Willow Bark (a natural precursor to salicylic acid), Nattokinase NSK-SD™ (a fibrinolytic enzyme), Resveratrol, and Ginger—all of which possess mild natural platelet-modulating properties that could interact with blood-thinning medications.

Why does the supplement label contain a warning regarding female fertility?

Cyclooxygenase-2 (COX-2) plays a physiological role in the rupture of the ovarian follicle and the subsequent release of the egg during ovulation. Any compound that potently inhibits COX-2—whether synthetic prescription medications or high-potency natural botanicals—can temporarily and reversibly delay ovulation. Women actively trying to conceive should discontinue use of COX-2-modulating supplements.

Is Source Naturals Inflama-Rest gluten-free and vegan?

Inflama-Rest is free of wheat, gluten, dairy, egg, and artificial preservatives. However, it contains Vitamin D-3 (derived from lanolin/sheep's wool) and Nattokinase (derived from fermented soy). As a result, it is suitable for vegetarians who consume lanolin-derived D-3, but it is not strictly vegan, and it is contraindicated for individuals with severe soy allergies.
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