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Search Term: " KnockOut "
Night Health: A new approach to improving sleep.   
Date:
May 12, 2006 05:41 PM
Our night health, including the quality of our sleep and dreams, may be the most critical overlooked factor contributing to both emotional and physical illness in modern times. For millions, night is a time of growing frustration and deepening struggle with insomnia as well as compromised and insufficient sleep. Mounting data has confirmed that sleep problems are strongly associated with virtually all major illnesses ranging from cardiovascular disease to diabetes, infections and cancer, and obesity to depression. Night health refers to a new approach to sleep and dreams that integrates complementary and alternative medicine with effective conventional perspectives. It is essentially a comprehensive body-mind approach to sleep. The first in a series of articles introducing the concept of night health, this article begins with a closer look at the limitations of the simulated sleep offered by sleeping pills. It then examines the basic alternative of supplemented sleep: the place of natural sleep-supporting supplements. Finally, it offers suggestions for increasing the utilization of such alternatives by supplementing supplements with essential information, education and guidance offered by a new and unique software program and the first book about integrative sleep health. Simulated Sleep As the public becomes increasingly aware of the health ramifications of sleep disturbances, more and more people are turning to sleeping pills. In fact, according to the IMS Health research, about 42 million prescriptions for sleeping pills were filled last year in the U.S. This represents a nearly 60 percent increase over the past five years alone. Some projections anticipate that the current $2.7 billion in annual sleeping pill sales will more than triple by 2010. But instead of solving the problem, sleeping pills often make sleep problems worse. Sleeping pills commonly result in dependence. They can alter normal sleep architecture, cause amnesia and residual daytime “hangovers,” and they often result in rebound insomnias when discontinued. Some sleep specialists argue that sleeping pill use is further associated with significant increases in mortality. Given the sense of desperation that can accompany insomnia, even such very serious concerns have not prevented sales of sleeping pills from skyrocketing in recent years. We are currently witnessing an unprecedented advertising campaign on the part of the pharmaceutical industry designed to convince the public that sleep medications are indeed a safe and effective strategy for addressing sleep problems. Despite clever and seductive advertising, however, it remains highly questionable whether sleeping pills can truly offer us sleep. I believe it is more accurate to say that they result in a kind of artificial or simulated sleep. Compared to natural slumber, sleeping pills cause a chemical KnockOut. Unfortunately, so many people have slept poorly for so long, they have forgotten what it is like to experience truly restorative, deep and refreshing natural slumber. Instead, many people now hold a naïve, limited sense of healthful sleep, confusing it with being knocked out. And sleeping pills satisfy that very naïve notion of sleep. Supplementing sleep Rather than artificially simulating sleep with chemical KnockOuts, sleep-promoting supplements such as melatonin, valerian, and other botanicals support that body’s own sleep-facilitating mechanisms more naturally. Such products work in greater harmony with nature and, unlike conventional drugs, they do not stimulate sleep, they supplement sleep. I think of natural supplements inviting us to sleep. The very potency of many natural products lies in their very gentleness, which works cooperatively with both body and mind to induce healthful sleep. I believe that the potential benefits and markets for such supplements remain largely untapped. Consumers’ expectations that sleep aids should knock them out rather than gently assist them in letting go into sleep must be addressed through targeted education and information campaigns. Consumers also need to learn how to use alternative sleep supplements in the context of a healthy sleep lifestyle or positive night health. Supplementing supplements As helpful as they can be in promoting night health, sleep supplements alone will not do the trick. In fact, I believe many people get discouraged and discount the potentially positive benefits of sleep supplements after using them without proper guidance and understanding. Sleep supplements work best when they are geared to work synergistically as a part of a larger night health promotion program. The availability of a wide range of over-the-counter health supplements offers an important freedom in healthcare choices. But with increased freedom comes increased responsibility. Consumers need to become significantly more informed. Particularly with regard to night health, such supplements need to be personalized and prescriptive. When it comes to sleep health, one size does not fit all. Whether we choose melatonin or valerian or a specific blend depends upon who we are and exactly what we need. By prescriptive I do not mean ordered by a physician, but specifically tailored to the needs of the individual. Because of a significant shortage of health care professionals knowledgeable about sleep and the alarming trend towards increased use of sleeping pills, I have assisted in the development of a unique software program that provides sleep solutions that are both personalized and prescriptive. After more than a decade in development, the sleep advisor—an expert software system that thoroughly evaluates and provides personalized comprehensive recommendations for improving sleep—is now available. More recently, I completed the first truly integrative book on night health. Healing night: the science and spirit of sleeping, dreaming, and awakening offers a new, comprehensive perspective on night health that complements the sleep advisors high pragmatic approach. Together, healing night and the sleep advisor offers essential supplements to sleep supplements. Rubin R Naiman is a psychologist and clinical assistant professor of medicine at the university of Arizona’s health sciences center. He is also the sleep and dream specialist for dr. Andrew weil;s world renowned program in integrative medicine. Currently he serves as the sleep specialist at Miraval Resort, and is in private practice in Tuscon, AZ. The above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider. The information in this article has not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Rubin R. Naiman, PhD
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1276) The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease  
Date:
June 09, 2005 05:22 PM
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease Presented at the 2005 World Garlic Symposium
Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005. “For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.” Presentation highlights included:
Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.
“Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.” Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. . Abstracts PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892 Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and KnockOut models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders. INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events. INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.
Bibliographies David Heber, MD, PhD, FACP, FACN Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center Matthew Budoff, MD, FACC Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.
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