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Search Term: " L-Leucine "
Can L-Leucine Help Glucose Metabolism And Insulin Function?   
Date:
June 02, 2014 08:54 AM
What is a leucine
What does leucine do L-Leucine has direct bearing on the amount of insulin produced. L-Leucine will stimulate the amount of insulin produced by the pancreas. One of the ways in which it influences the amount of insulin produced is by enhancing glutaminolysis by allosterically activating GDH (glutamate dehydrogenase). Benefits of leucine Increased insulin levels have a major implications on glucose metabolism. Increased insulin level will directly result into faster glucose absorption into the blood stream. Increased glucose metabolism prevents the body from using lean muscles to supply energy during workouts. Unlike isoleucine and valine, L-Leucine are converted to glucose slowly and thus you can have sustained energy for long. It is also very effective in muscle building. By stimulating insulin release and glucose metabolism, it enables key nutrients such as amino acids, Creatine and glucose to enter muscle cells. Since insulin will stimulate rapid muscle synthesis while inhibiting protein breakdown, L-Leucine will build lean muscle mass with a short period. L-Leucine is alternative to steroids, it is safer and its effects are lasting. During workouts, it supports oxidative metabolism in muscles and decrease protein degradation. If you are looking for the best way you can build muscle mass and strength without adverse effects, L-Leucine is premier supplement. Apart from building muscle, L-Leucine will also improve brain functions. You can take more workouts. L-leusine supplement has been used by many body builders and has been proved beyond doubt to be effective supplement. If you have been wondering if L-Leucine help glucose metabolism and insulin function, no doubt it is can. You can also red more by visiting //www.livestrong.com/article/261185-what-are-the-functions-of-leucine/ //www.ncbi.nlm.nih.gov/pmc/articles/PMC2969169/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3131) L-Leucine as an essential Amino Acid 
Date:
May 31, 2014 06:54 AM
L-Leucine is a a-amino acid with the chemical formulae HO2CCH(NH2)CH2CH(CH3)2. It is a hydrophopic amino acid to its aliphatic isobutyl side chain. L-Leucine is an essential amino acid since the human body can’t synthesize it, and it therefore must be ingested. What is an essential amino acid These are the amino acids that can’t be synthesized by the body of the organism hence it must be supplied in the diet. These amino acids is important not because they are important than others, but simply because the body can’t synthesize them. Phenylalanine, L- Leucine, Valine, Tryptophan, Threonine, meyhionine, iso - Leucine, lysine and histidine are some of amino acids regarded as essential for humans beings. The main difference between essential and non-essential amino acids is somehow since some proteins can be synthesized from others. The sulfur containing amino acids such as L-Leucine may sometimes be referred to as an essential amino acid. Effects of L-Leucine deficiency Majority of amino acids are important in the human diet. An experiment carried out by William Cummings Rose showed that lack of L-Leucine results to symptoms of exhaustion, nervousness and dizziness. Results further showed that these symptoms were encountered to lesser extent whenever human subjects were deprived of an essential amino acid. In plants and other micro-organisms, L-Leucine is synthesized from pruvic acid by several enzymes. These enzymes include: · a-Isopropylmalate synthase · L-Leucineaminotransferase · a-Isopropylmalate isomerase · Acetolactate synthase · Acetohydroxy acid isomeroreductase · Dihydroxyacid dehydratase Importance of L- Leucine L-Leucine is used by the adipose tissue, liver and the muscle. In muscle tissue and adipose L-Leucine is used in the formation of sterols. Ironically the combined usage of L-Leucine in the muscle and adipose is seven times greater than its use in the liver. L-Leucine is also used in stimulation of the muscle protein synthesis. In dietary , L-Leucine is used in to slow down the degradation of muscle tissue by increasing the synthesis of muscle proteins in aged rats however this does not work in elderly men. L-Leucine helps you lose weight and spare muscle when dieting. However L-Leucine can’t be associated as the main reason in muscular growth for the entire populatin. L-Leucine activates the mammalian target that regulates the growth cells in rats. Negative effects of L- Leucine L-Leucine cause neurologic complications which may be fatal if not control in time. Studies also show that over activity of the liver is caused by taking L-Leucine supplement, excess L-Leucine may also cause pellagra, whose symptoms include dermatitis, diarrhea, dementia and eventually death.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3130) Strengthen The Liver and Kidneys With Leucine
Date:
April 27, 2009 02:08 PM
L-Leucine is an amino acid that is used by the body to fuel exercise and muscle-building to provide you with that athletic edge that gets you ahead of your opponents. It does so in a number of ways, none of them specifically by the direct generation of energy as such. It is also an essential amino acid, since it cannot be manufactured by your body and hence must be taken as a supplement or as part of your diet. Foods rich in leucine include nuts, whole wheat products such as wholemeal bread, and brown rice. It is a hydrophobic amino acid, meaning that it does not like water. It is also one of three essential branched chain amino acids, the other two being L-valine and L-isoleucine, and offers many benefits to athletic performance that shall be discussed below It also helps to preserve the body's stores of glycogen, used as an emergency energy source. Other than these properties, it possesses others, such as the maintenance of the nitrogen balance in the body. So how does it work to fuel your body while you are exercising? The answer is not as you might think. L-Leucine doesn't increase your energy levels as creatine does when it elevates your ATP (adenosine triphosphate) levels. ATP is the molecule of energy that is synthesized in your body cells, and is then converted back to ADP, the diphosphate, with the release of energy in the form of muscular contractions. This amino acid is what is referred to as a 'limiting' substance, in that the other amino acids cannot do their jobs in your body unless you have sufficient L-Leucine in proportion to them. Specifically, you need two parts of L-valine and two parts of L-Leucine to one part of L-isoleucine for optimum usage of the food that you eat. Therefore you cannot just take the supplement without considering how much should be taken to ensure this balance. Excess will be wasted and a deficiency would fail to make proper use of the protein content of your food. If you suffer from a deficiency, therefore, your body cannot make best use of the protein in your diet to the extent that muscle tissue will not be generated during exercise. In fact it causes catabolism, or the breakdown of muscle tissue, resulting in a loss of performance and possible increase in fatty tissue as opposed to lean muscle. The only way to build muscle is take in sufficient nitrogen in the form of amino acids and protein, along with L-Leucine to put that protein to best use. One of the major properties of L-Leucine is in stimulating the synthesis of skeletal muscle tissue and by using a supplement, the protein balance can be positive after a workout. It has been shown that this protein balance is generally negative until specifically L-Leucine is consumed. The way it works is to activate a muscle-generating pathway known as mTOR (mammalian Target of Rapamycin). mTOR is normally activated when the levels of ATP in the muscle cells is high, and when these levels drop then mTOR is deactivated. The activity of mTOR is sensitive to the concentration of L-Leucine, and when the concentration of the amino acid in the body rises it informs mTOR that the protein in the diet is sufficient to manufacture skeletal muscle tissue, and so mTOR s activated. Exactly how this is done is unknown, but is a fact the mTOR depends upon both L-Leucine concentration and also ATP levels. This amino acid also decreases catabolism through a number of different mechanisms, one of which involves increasing insulin levels. In fact, when insulin and L-Leucine levels increase at the same time, there is a synergy that promotes the synthesis of new protein. Not only that, but the response of insulin to the presence of carbohydrates is enhanced, this resulting in an enhancement of your body's metabolism. The amino acid can also be used to help those suffering from kidney and liver problems because it increases liver protein synthesis. It is therefore a useful adjunct both to diabetics and those suffering from liver and kidney disease. However, because L-Leucine is an essential amino acid with so many important properties, a deficiency can have specific consequences. Catabolism has been stated earlier as one such reaction to a deficiency, and others include decreased energy levels and irregularities in the levels of blood sugar. Everything about this substance is not good however, and when taken by itself in excess, it can reduce the amount of the other amino acids in the blood, particularly of the other two branched chain amino acids (BCAAs). This in turn upsets the balance of amino acids, and reduces further the ability of the body to produce muscle tissue until a balanced supplement is taken. Leucine also helps to maintain the nitrogen balance. It is essential for the human body to maintain a positive nitrogen balance, and L-Leucine supports this. In fact, one study has demonstrated that after 12 hours infusion with L-Leucine, nitrogen balance was improved by as much as 23%. A supplement alone is not always sufficient to maintain a positive nitrogen balance. It is generally essential that you rest your body for a sufficient length of time to allow protein to be generated. If you don't take the required amount of rest, a surplus of protein could be used to maintain energy levels rather than replace lost protein and maintain a good nitrogen balance. A positive nitrogen balance is essential for the generation of muscle tissue, such as in bodybuilding for example, since all proteins contain nitrogen and the net nitrogen intake must exceed the excretion rate. Not in gaseous form, of course, but in the intake of amino acids and proteins. The more positive your nitrogen balance is, the faster you will recover after exercise. It is essential for anabolic exercise. L-Leucine, therefore, is a supplement that can help to maintain your current muscle mass while undergoing strenuous exercise, in addition to increasing it while resting. It offers other health benefits, one being helping to maintain clarity of thought in the aged. However, it is for its effect on muscular build-up and the athletic edge that provides that the supplement is most commonly taken.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1997) Enhanced Muscle Growth with Free Form Amino Acids
Date:
September 07, 2006 01:30 PM
Notably L-Leucine, L-Valine, and L-Isoleucine prevent muscle tissue breakdown during exercise. Free form amino acids accelerate muscle tissue healing and growth by providing and specific amino acid profile where they are needed, directly in muscle tissue. The result is faster muscle and strength gains, as well as enhanced recovery.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1374) Muscle Mass - Reach Your Maximum Muscle Potential 
Date:
June 04, 2005 09:49 AM
The serious athletes of today know how much it takes to fulfill their competitive goals: careful training, a strong will, and also the right kind of nutrition. Sports science now makes available key nutrients which help assure that strenuous workout regimes will show results. Results that are both nutritionally sound and dramatically visible, without the need for dangerous steroids or chemicals. MUSCLE MASS™ is such a state-of-the-art sports science formula. THE PURPOSE OF MUSCLE MASS ™ is to help translate distant goals for greater strength and power into quicker, awesome reality. It is the premier formula combining all essential nutrients known to maximize muscle development and optimize strength.
In sum, all these balanced, cutting-edge factors combine to assist you in meeting the challenges you’ve set for your body. Power, endurance, strength, tone, and the winner’s circle are now closer.
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Leucine is one of 3 amino acids that increases muscle mass and will also help you to recover after exercise. Leucine supplies the body with energy and regulate blood sugar. Being an essential amino acids, it cannot be synthesized by the body and thus you need to get it from food or supplements. But Can L-Leucine help glucose metabolism and insulin function?
Introduction
