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Isoflavones Darrell Miller 9/2/08
Flax Seed Oil Darrell Miller 8/7/08
Progesterone Cream - Supports Hormonal Balance Darrell Miller 6/28/05
Natural Progesterone Cream - For Woman of All ages Darrell Miller 6/4/05



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Isoflavones
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Date: September 02, 2008 10:10 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Isoflavones

An isoflavone from soy has been evaluated for its effect on various female functions such as the menopause and some effects on estrogens. Soy products have been part of the diet in the Far East for thousands of years, and it is a known fact that these people suffer fewer incidences of conditions such as breast cancer, menopausal problems, rectal cancer and diseases of the heart and joints.

The benefits that such a diet appeared to confer on those taking it initiated many studies into the active constituents of soy, and how the biochemistry involved imparted these benefits. A result of this was an intensification of investigations into many so-called -women's functions' or 'women's problems' that hitherto had been accepted as a part of life. Now, however, they are better understood, just as many other components of the Oriental diet are being found to have wider implications in terms of disease prevention and increasing life expectancy. So back to soy and its isoflavone content.

Soy contains a number of isoflavones, commonly known as Phyto-Estrogens - plant estrogens - because their chemical formula is similar to that of estrogen, a female hormone. Isoflavones possess some properties that support the beneficial properties of estrogens, and others that suppress some of the risk factors possessed by estrogen. We shall discuss here how these isoflavones are related chemically to estrogens, and how they can be used to support some specific female functions.

In order to understand how isoflavones work we go back to the 1980s, when alpha and beta estrogen receptors were discovered. Until then, the biochemistry of estrogen was not fully understood, and problems connected with estrogen had not been fully investigated.

Like all hormones, estrogen works by finding receptors that are located on cells. With regard to estrogen there are two types of receptor. The beta receptors are connected with the beneficial properties of estrogen, while the alpha receptors tend to lead to the unfavorable effects such as cancers related to estrogen. Each of your different tissue types possesses different ratios of these two receptor types.

The unfavorable alpha receptors predominate in tissues such as the breast, ovaries and uterus. The favorable beta receptors predominate in the blood cells, bladder, prostate gland, thymus and bones. Studies have indicated that isoflavones appear to attack to the beta receptors and simulate the beneficial effect of estrogen when the levels of estrogen in the body are low, and allow the proper functioning of these cells in the body.

The alpha cells are also populated by isoflavones, which then protect these areas of your body against cancers that can be stimulated by estrogen, such as cancers of the breast, ovaries and uterus. It appears that cancers that can develop when the alpha receptors are populated by estrogen do not occur when isoflavones have captured them

Isoflavones are present in the form of glucosides. These are composed of sugar and non-sugar components, the latter known as aglycones, and the main isoflavones in soybean are based on the three aglycones genistein, daizein and glycetein. The glucosides are water soluble and are broken down into enzymes known as B-glucosidases in the intestine. This releases the aglycones that can be further metabolized into other substances.

Current studies are examining the possibility that a diet rich in isoflavones taken early in life up to teenage years can reduce the incidence of breast cancer in later years. Isoflavones have been used in the laboratory to reduce the growth of prostate cancer cells, and animal studies have reinforced this finding. The fact that Japanese men suffer less from prostate cancer than those eating diets low in isoflavones also tend to reinforce this connection.

The same mechanism can be used to in prostate cancer by binding to testosterone receptors. Genistein, in particular, can help treat certain types of cancer by inhibiting enzymes such as tyrosine kinase that can become hyperactive and overstimulate the growth of potentially cancerous cells.

It is probable that the estrogen binding facility of isoflavones complements the activity of estrogen in women with low levels of hormone. When the female estrogen level is low, isoflavones can reduce the effects of the menopause and symptoms such as hot flushes and night sweats become less severe. While not all women benefit, it has been found that women with these symptoms tend to suffer less when taking a diet rich in soy foods containing isoflavones.

In addition to its moderating effect on these cancers, and its effect on the menopausal symptoms on many women, soy isoflavones possess a few other beneficial health properties. They are strong antioxidants, and help to support the immune system by mopping up free radicals. They also help to protect from atherosclerosis by preventing the oxidation of LDL cholesterol and depositing it as plaque in the arteries.

There is evidence that isoflavones in the diet can help to maintain strong healthy bones. This is largely through the fact that Chinese women taking a diet rich in soya suffer fewer fractures than those on a low soy diet, but studies are continuing into potential reasons for this. Estrogen receptors in bones regulate bone growth and density. Isoflavones can modulate these receptors and promote greater bone density just like estrogen hormones with out estrogen side effects.

Isoflavones have few dietary sources, the richest being soybeans and other soy products. These are very low in the non-Asian diet, so few people, other than Asians, receive the benefit of these phytochemicals. This is believed to be the major reason for Asians suffering significantly lower rates of certain cancers than non-Asians.

Soy milk and tofu are the richest sources, although there is no standardization of isoflavones in soy-based foodstuffs. This is because the isoflavone content varies according to growing conditions, although a diet containing the recommended quantities of soy foods, such as soy milk or soy beans, together with a low cholesterol diet, should help women to overcome many of the problems associated with excess estrogen, or a lack of it especially when taking in conjunction with essential fatty acids.

Any supplement containing soy will be beneficial to most women, particularly during the menopausal stages, although the effect of isoflavones on certain cancers to which women are susceptible cannot be ignored. Such supplements should therefore be used by all women from at the teens onwards, studies having indicating that an isoflavone-rich diet should be beneficial over the longer term.

Isoflavones from soy is effective in helping to support female functions, although the normal Western diet is traditionally very short in these forms of phytoestrogen. Isoflavones can modulate estrogen receptor sites through out the body helping the body regulate its functions and easy the symptoms related to a estrogen deficient body.

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Flax Seed Oil
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Date: August 07, 2008 01:53 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Flax Seed Oil

Flax seed naturally contains a variety of different categories of essential fatty acids, which includes alpha linoleic acid, linoleic acid, and omega-9 oleic acid. A lot of flax seed’s benefits are a function of its content of alpha linoleic acid, which is converted in the body to a longer chain of omega-3 EPA. Research has proven that supplementation with flax seed oil can help to increase the EPA concentrations in many tissues of the body. One of the main areas of research has been inflammation.

Many factors contribute to inflammatory reactions, including omega-6 linoleic acid, which can be converted into pro-inflammatory substances. Flax alpha linoleic acid can convert into EPA, which has the ability to convert into a prostaglandin that has anti-inflammatory properties. In inflammatory states, alpha linoleic acid and EPA compete with linoleic acid for enzymatic metabolism, resulting in a decreased production of pro-inflammatory substances. Many studies have found that the use of flax seed oil in domestic food preparation can reduce the production of inflammatory cytokines.

These studies have also shown the ability of omega-3 rich fish oils to inhibit inflammatory mechanisms in the autoimmune disease lupus nephritis, which lead to the investigation into flax having any abilities in this area. One trial found that 30g/d of flax seed was optimal for improving kidney function, decreasing inflammation, and reducing atherosclerotic development. Flax also contains antioxidants, which may be helpful to those who have SLE.

Research has also been conducted to investigate the hormonal modulating effects of ingesting lignans, which are antioxidant and Phyto-Estrogenic compounds that are found in flax seed. Clinical evidence indicates that phytoestrogens have an anti-cancer effect on the breast. Experimental studies in animals and humans have also demonstrated flax’s anti-cancer effects, with a 1998 review indicating that the consumption of flax may be used as a secondary prevention method against breast cancer. Flax seed has also been shown to promote prostate health, as it plays a key role in the treatment of an enlarged prostate.

The cardiovascular system is also another area of research focus for flax seed. One study showed that three months of flax seed supplementation resulted in LDL cholesterol levels dropping significantly, while HDL cholesterol did not change. Other research has shown serum lipid level reduction, but a large amount of flax seed was required to be consumed to get the same lipid-lowering effects as fish oils. Flax lignans also possess anti-platelet activating factor activity and antioxidant activity. Animal research has shown that flax seed reduced the development of aortic atherosclerosis’ by 46 percent and suppressed oxygen-free radicals.

The research concluded that dietary flax seed supplementation could prevent hypercholesterolemia-related heart attack and strokes. Lastly, the elasticity of arteries is an important factor of circulatory function, which decreases as the cardiovascular risk increases. Research has proven that obese people consuming a diet high in ALA from flax seed oil experience a marked rise in arterial elasticity, which reflects a rapid improvement in the arterial circulation.

Although flax seed offers many potential benefits, ingesting the right form of supplemental flax is crucial to gaining these benefits. Flax oil supplements are a good source of EFAs, but they do not provide great amounts of lignans. On the other hand, whole or ground flax seed is effective, but is not especially palatable. The best option of flax seed is the liquid in capsule form, as it delivers both EFAs and lignans. The nutritional value and certain beneficial results can be gained by consuming about 3,000 mg daily.



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Progesterone Cream - Supports Hormonal Balance
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Date: June 28, 2005 09:40 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Progesterone Cream - Supports Hormonal Balance

Recent medical reports have profoundly shaken popular beliefs about the safety of Hormone Replacement Therapy (HRT) for women in menopause. You may be one of the six million women who are searching for alternatives. Source Naturals PROGESTERONE CREAM and Phyto-Estrogen CREAM can help address normal menopausal discomforts, when used as part of a care for their own health needs. Source Naturals is committed to joining with your health food retailer to help insure that right.

Menopause and Hormonal Balance

Public confidence in hormone replacement therapy (HRT) suffered a major blow when the National Heart, Lung, and Blood Institute of the National Institutes of Health halted a large clinical trial out of concern for the safety of participants. Women are looking for natural alternatives to risky HRT.

Source Naturals Progesterone CREAM and Phyto-Estrogen CREAM address the hormonal fluctuations that bring on the first disturbing hot flashes, night sweats, and mood swings. Used together or separately, these creams address declining levels of progesterone and estrogen.

Progesterone Cream from Woman-Friendly Soy

Progesterone is a steroid hormone made by the corpus luteum of the ovary at ovulation, and in smaller amounts by the adrenal glands. It is a precursor to most other steroid hormones, including cortisol, androstenedione, estrogen and testosterone. Because it is the precursor to so many hormones, progesterone is crucial for overall hormone balance. Yet progesterone levels can drop to near zero during menopause. Source Naturals PROGESTERONE CREAM supplies natural progesterone from soy.

Unlike creams which don’t divulge their progesterone content, Source Naturals PROGESTERONE CREAM is guaranteed to contain 500 mg of progesterone per ounce! This pure white cream softens and smoothes skin. Along with natural progesterone, it contains aloe vera, wild yam extract, natural vitamin E, lecithin phospholipid, jojoba oil, and extracts of ginseng root and grapefruit seed. Natural rosemary oil is added as a fragrance. Available in both tubes and jars for your convenience.

Phyto-Estrogen Cream: Plant Compounds Renowned for Menopause Estrogen levels drop 40-60% at menopause. Phytoestrogens—estrogens from plants—have been shown to bind to the same receptor sites as estrogen, helping maintain normal menstrual cycles and menopausal transitions. When there is too little estrogen (the situation during menopause), phytoestrogens substitute for the lack of human estrogen. Conversely, when estrogen levels are high (as in some women who experience PMS), phytoestrogens compete with human estrogen for binding to receptors and decrease overall estrogenic activity.

Source Naturals Phyto-Estrogen CREAM is an almond-colored cream that can be massaged into smooth skin areas to add oil-rich, moisture-binding protection. Phyto-Estrogen CREAM offers some of the finest phytoestrogens in the botanical world, including 60 mg of soy isoflavones per ounce. Phyto-Estrogen CREAM also contains pomegranate seed juice (a natural source of estrone), red clover tops extract, black cohosh root extract, and dong quai root extract, along with aloe vera gel, natural vitamin E, cocoa butter, grapefruit seed extract, rosemary oil, and natural cherry almond fragrance.

Warning: Phyto-Estrogen Cream is not for use by women of childbearing age. DO NOT USE if you are pregnant or breastfeeding, or if you may become pregnant.

Liposome Delivery

Source Naturals offers you the first progesterone and phytoestrogen creams to utilize unique liposomal delivery of key ingredients. Liposomes are micro-penetrating lipid spheres made from lecithin, which pass through skin layers more easily than non-liposomal creams—for highest possible penetration of skin cells. Both creams are available in 2 and 4 oz jars. PROGESTERONE CREAM is also available in 2 and 4 oz tubes.

Lifestyle Tips for Menopause: A Strategy for Wellness

Eat Well: In certain cultures, hot flashes are practically unknown. It is generally true that women in these cultures eat foods rich in phytoestrogens. For example, in Southeast Asia, where soy proteins comprise 20% to 60% of daily protein intake, epidemiological studies suggest an association between a positive, trouble-free menopause and soy consumption.

Lignans—phytoestrogens found in flaxseed oil and unprocessed olive oil—may also have a protective effect. You should eat fresh, organic vegetables, fruits, cereals, beans, whole grains and small portions of fish or hormone-free chicken. Increase fluids and eat low-fat dairy foods. Avoid fatty meats, sugar, processed foods, fried foods, and chemicals. Adequate calcium intake— 1,500 mg per day—is crucial.

Use Supplements: Source Naturals HOT FLASH is an excellent complement to PROGESTERONE and Phyto-Estrogen CREAMS. A recent comprehensive scientific review of natural menopause products (Annals of Internal Medicine 11/19/02) singled out soy isoflavones and black cohosh for their benefits in addressing hot flashes. Unlike most products, HOT FLASH contains clinical potencies of both soy isoflavones and standardized black cohosh extract. In addition, HOT FLASH contains additional herbs, renowned for use in menopause: vitex, licorice root and dong quai. To be sure you are covering all your nutritional bases, take a good daily multiple like MENOPAUSE MULTIPLE, especially designed for women 40+ years old.

Maintain a Healthy Weight: Women who are overweight have an increased risk of heart disease, while those who are thin or underweight are more susceptible to osteoporosis and hot flashes.

Rest and Relax: It is important to get adequate sleep, take naps if you feel tired, and avoid stress. Meditation and yoga can be helpful in reaching a state of calm. Take Care of Your Skin: A 1997 study of 3,875 postmenopausal women documented the relationship between low estrogen levels and skin dryness and loss of elasticity. Research has associated wrinkling with consumption of full-fat dairy products, butter, margarine, fatty meats and sugar. Drink lots of water—at least 1.5 liters daily. Water flushes out wastes, and acts as an internal moisturizer, keeping skin hydrated and supple. Spring water is beneficial since it contains trace minerals vital to healthy skin. For radiant skin, you should also try the Source Naturals SKIN ETERNAL™ family of creams and serums. This advanced cosmetic system recharges and revitalizes all skin types. Keep Cool. Avoid triggers such as spicy foods, caffeine, alcohol, overheated rooms, hot beverages and stress. Wear layered clothing, and choose natural fabrics, such as cotton or wool.

Stay Active: Exercise benefits the heart and bones, helps regulate weight and contributes to overall well-being. Weight-bearing exercises are especially important for increasing bone mass. Kegel exercises (tightening and relaxing of the pelvic muscles) can improve bladder control, and may enhance sexual pleasure. Try Complementary and Alternative Medicine (CAM): Alternative therapies— herbal remedies, acupuncture, massage, chiropractic, naturopathic medicine and much more—can help you cope with the physical and emotional changes of menopause.

References
Writing Group for the Women’s Health Initiative. 2002. Journal of the American Medical Association, 298(3):321-329. Lee, John R., M.D.and Virginia Hopkins. 1996. What Your Doctor May Not Tell You About Menopause. Warner Books: New York.



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Natural Progesterone Cream - For Woman of All ages
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Date: June 04, 2005 01:45 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Natural Progesterone Cream - For Woman of All ages

Source Naturals® Eternal Woman™ PROGESTERONE CREAM is the first progesterone cream to utilize unique liposomal delivery of key ingredients. Liposomes are micro-penetrating lipid spheres made from lecithin, which pass through skin layers more easily than non-liposomal creams. Source Naturals PROGESTERONE CREAM features natural progesterone from healthful soy. Unlike creams which don’t divulge their progesterone content, Source Naturals PROGESTERONE CREAM is guaranteed to contain 500 mg of progesterone per ounce! This pure white cream softens and smoothes the skin. Along with natural progesterone, it features aloe vera, Mexican wild yam extract, natural vitamin E, lecithin phospholipid, jojoba oil, and extracts of sage, black cohosh root, ginseng, marigold and grapefruit seed. Rosemary oil is added as a fragrance. Source Naturals PROGESTERONE CREAM is available in 2 and 4 oz jars. It is part of the Eternal Woman line of products and is suitable for women of all ages.

Source Naturals® Eternal Woman™ Phyto-Estrogen CREAM offers some of the finest phytoestrogens in the botanical world, including 60 mg of soy isoflavones per ounce. For the first time ever, soy phytoestrogens are included in a liposomal delivery system. Liposome delivery is ideal for this product because the soy actually becomes part of the liposome membrane—for highest possible penetration of skin cells. Source Naturals Phyto-Estrogen CREAM is an almond-colored cream which can be massaged into smooth skin areas to add oil-rich, moisture-binding protection. In addition to soy isoflavones, every ounce of Source Naturals Phyto-Estrogen CREAM contains 150 mg of pomegranate seed juice (a natural source of estrone), 100 mg of red clover tops extract, 80 mg of black cohosh root extract, and 25 mg of dong quai root extract, along with aloe vera gel, natural vitamin E, grapefruit seed extract, rosemary oil and a natural cherry almond fragrance. Source Naturals Phyto-Estrogen CREAM is available in 2 and 4 oz jars. It is part of the Eternal Woman line of products: for the Freedom to Change ™ naturally.



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