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Your Mood and mental health
Bipolar disorder is a terrible mental disease that affects millions of people worldwide. It is characterized by periods of severe depression, followed by periods of extreme euphoria. It can be rapid cycling, which means the person with the disease goes through many moods a day.
Once you figure out what the underlying cause such as brain chemistry, then you can take a natural approach to help boost serotonin or dopamine.
Always remember to be careful if on MAO inhibitors or SSRI inhibitors before taking natural remedies like 5-htp or dopabean to mess with serotonin and dopamine levels in the brain.
California Proposition 65 (Prop 65) and Progesterone Cream Warnings
February 17, 2006 06:29 PM
Scientific Safety Information on Progesterone
California Proposition 65 (Prop 65) and Progesterone Cream Warnings Amy Kosowski, M.S., LDN
Prop 65: What is it?
Proposition 65, the Safe Drinking Water and Toxic Enforcement Act of 1986 , was enacted as a ballot initiative in the state of California in November of 1986. The Proposition was intended by its authors to protect California citizens and the State's drinking water sources from chemicals known to cause cancer, birth defects or other reproductive harm, and to inform citizens about exposures to such chemicals 1.
Proposition 65 requires the Governor to publish, at least annually, a list of chemicals “known to the state to cause cancer or reproductive toxicity .” Progesterone, as well as other human hormones, appear on this list 1. Set forth below is the information that formed the bases for the addition of progesterone to the Prop 65 list by the California Office of Environmental Health Hazard Assessment (“OEHHA”).
Prop 65 and Progesterone - Perspective
In August of 2004, OEHHA published a document stating the rationale for the addition of Progesterone to the Prop 65 list 2. This document is a review of human, animal, and in vitro studies that used progesterone, synthetic progestins, and other progestagens (progesterone-like compounds). Experimental data from the use of all of these compounds were mixed together, along with data from studies using other steroid hormone derivatives (mainly synthetic estrogens) and many different methods of administration.
Although this review covered the existing scientific literature on progesterone and its many derivative compounds, there are many problems with the type of data analysis that was employed.
First, progesterone is endogenous to humans and necessary for bone and reproductive health while progestins and other synthetic progestagens are not. Progestins and progestagens are similar in molecular structure to progesterone, but when they bind to progesterone receptors, their effects are usually much stronger and more likely to cause abnormal physiologic responses 3, 4. Furthermore, the majority of the studies concerning the health effects of these progesterone derivatives involved combinations with synthetic estrogens 2-4.
There were very few studies mentioned in the 2004 document that used exclusively bio-identical progesterone (the kind found normally produced by humans as well as that used in progesterone creams), and those studies that did were at supra-physiologic doses (very high). The doses of progesterone ranged from 10-1000 times the dose usually recommended by manufacturers of progesterone creams 2, although in a few cases, the doses were closer to the recommended dosages.
The route of administration of progesterone is also at issue. All of the studies cited in the OEHHA document used either oral, injected, or suppository forms of hormones; none was conducted using transdermal creams. This is an important consideration because hormones absorbed through the skin are metabolized differently than hormones that are administered via other routes 5, 6.
Putting it Together
While the OEHHA Prop 65 reference document on progesterone 2 is a broad survey of the published scientific literature examining the potential effects of the pharmaceutical use of progesterone and its synthetic derivatives, it is not clear at all that these effects would be seen with the use of low-dose progesterone creams.
The OEHHA Prop 65 progesterone document evaluates a broad range of information regarding progesterone and synthetic materials that are not natural progesterone. The conclusion reached was not challenged, and it is on that basis that progesterone creams now carry the Prop 65 warning.
1 California OEHHA Web Site: //www.oehha.ca.gov/prop65/p65faq.html .
2 Reproductive and Cancer Hazard Assessment Section, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency (2004) Evidence on the developmental and Reproductive Toxicity of Progesterone.
3 Campagnoli C, Abba C, Ambroggio S, Peris C (2005) Pregnancy, progesterone and progestin in relation to breast cancer risk. J Steroid Biochem Mol Biol 97(5):441-450.
4 Campagnoli C , Clavel-Chapelon F , Kaaks R , Peris C , Berrino F (2005) Progestins and progesterone in hormone replacement therapy and the risk of breast cancer. Steroid Biochem Mol Biol 2005 96(2):95-108.
5 de Lignieres B, Dennerstein L, Backstrom T (1995) Influence of route of administration on progesterone metabolism. Maturitas 21:251-257.
6 Gompel A, et al. (2000) Progestins were also proapoptotic in normal as well as in hormone-dependent breast cancer cells. Steroids 65(10-11):593-598.
7 Bu SZ ( 1997) Progesterone induces apoptosis and up-regulation of p53 expression in human ovarian carcinoma cell lines. Cancer 79(10):1944-50.
Pregnant and eating for two...
October 21, 2005 01:36 PM
Not - Quite - Dual - Nutrition
It’s time to ditch a dietary cliché often foisted on expectant moms. “try to keep in mind that you are not eating for two, you are carefully eating for one,” write Catherine Jones and prenatal nutrition expert Rose Ann Hudson in Eating for Pregnancy (Marlowe & Company), who add that pregnancy “is not a time to skip meal, eat junk food or lad up on empty calories for quick energy.” The idea is to eat a nutritious diet that allows you to gain weight gradually as your baby grows.
It helps to be at a healthy weight when starting a family. Being overweight makes conception more difficult, and at least one study ahs found a link between excess maternal weight and the risk of a birth defect called cleft palate (in which the roof of the mouth is split from behind the teeth to the nasal cavity). However, dieting during pregnancy may actually program a child for obesity by rewiring the developing brain, so try to lose weight before you try to conceive.
How much should you expect to gain over the course of nine months? “A lot depends on your unique circumstances and the advice of your health care provider, but in general you can anticipate adding from two to five pounds a month for the first 14 weeks and roughly a pound a week thereafter until your due date-between 25 and 35 pounds in total. That translates into roughly and extra 300 calories a day; Jones and Hudson say that more nourishment may be necessary if you are breastfeeding, extremely active or carrying more than one child. Since stress and anxiety often lead to out-of-control eating (and gaining), be sure to tend to your own emotional needs during what can be a very exhilarating, yet sometimes overwhelming, time of life.
For maximum nutrition try to eat a variety of foods while avoiding anything that provokes morning sickness. Whole grains provide both steady energy (unlike sugar-fueled spikes and crashes) and B vitamins to boot. Do not scrimp on fat-your baby’s developing nervous system depends on it-but “don’t use your pregnancy as an excuse to pig out, either,” warn Jones and Hudson. Stick with such unsaturated fats as olive oil along with rich sources of omega-3 fatty acids like flax seed oil. You definitely want to indulge in those omega-3s, which appear to boost infant intellectual development. Fish is a fine source of both omega-3 and the high-quality protein needed to build your baby’s tissues, but beware: Some species such as fresh tuna, swordfish, tilefish and king mackerel, can be contaminated with mercury. Your best low-mercury bets are catfish, pollock, salmon, and shrimp. (Other good protein sources include chicken, cottage cheese, lean red meat, yogurt and milk, all organically sourced whenever possible.)
Supplemental fish oil is another omega-3 possibility because “mercury is found in the muscle of fish and not in the oil,” according to OSU’s Jane Higdon, who suggests consulting your health care practitioner for advice. “If I was going to take a fish oil supplement, I’d look for one that the manufacturer is testing for PCBs (an industrial pollutant),” such as products that meet California’s Proposition 65 standards.
Don’t forget to stock the fridge with fresh produce. Fruits and veggies are richly endowed with vitamins and minerals; for example, making like Popeye and downing your spinach helps ensure you get plenty of folic acid and iron.
These superfoods also supply phytonutrients, substances that may actually help protect your baby against cancer even as they enhance your own well-being. Studies on the link between maternal diet and childhood cancer protection are in the early stages according to Dr. David Williams, a researcher at the Linus Pauling Institute, but he says that shouldn’t stop you from loading up on cancer-fighting green stuff. “Certainly among the vegetables the cruciferous ones (the broccoli family) are particularly valuable in protecting against cancer,” he says. “These vegetables are also a good source of fiber and vitamin C.”