Prostate Cancer and Nutritional Supplements

 

Years of research have discovered that the foods a man chooses to eat (or doesn’t eat) can have a profound impact on the health of his prostate gland. Because of this close nutritional link, prostate cancer may be the most preventable type of cancer (after smoking-related lung cancers).

Recently, there has been an incredible amount of research and investigation of prostate cancer. Many of these studies have explored the use of certain nutrients to prevent and actually treat prostate cancer. These nutrients, calcium D-glucarate selenium, broccoli, green tea, maitake, and lycopene are powerful prostate cancer fighters. All are available as nutritional supplements that men can take every day as an important part of a healthy diet.

In this issue of Ask the Doctor, we will discuss prostate cancer and how men can actually prevent it with the use of these six nutrients. Plus, if men already have prostate cancer, these nutrients can be an important part of their treatment regimen in fighting their disease.

 

Q. What does the prostate gland do?

A. The prostate is a gland in a man’s reproductive system. It makes and stores seminal fluid, the milky fluid that nourishes sperm. This fluid is released to form part of the semen. The prostate is about the size of a walnut and it is located below the bladder and in front of the rectum. The prostate actually wraps around the upper part of the urethra, the tube that empties urine from the bladder through the penis.

 

Q. What are the symptoms of prostate cancer?

A. Early prostate cancer often does not cause any symptoms. However, many symptoms of prostate cancer are also symptoms of other problems with the prostate, such as an infection or benign prostatic hyperplasia, a prostate enlargement associated with age-related changes.

A man who has any of these symptoms should see his health care practitioner for evaluation:

-A need to urinate frequently, especially at night

-Difficulty starting urination or holding back urine

-Inability to urinate

-Weak or interrupted flow of urine

-Painful or burning urination

-Difficulty in having an erection

-Painful ejaculation

-Blood in urine or semen

-Frequent pain or stiffness in the lower back, hips, or upper thighs.

 

Q. Are certain men more prone to get prostate cancer?

A. Age is the biggest risk factor: most prostate cancers occur in men over 65 years of age. A man’s risk for developing prostate cancer is higher if his father or brother has had the disease. African-Americans are at higher risk for the disease. Mechanics, farmers, sheet metal workers, and workers exposed to cadmium have also had high rates of prostate cancer.

 

Q. How is prostate cancer diagnosed?

A. A man who has any of these risk factors may want to ask his health care professional whether to begin screening for prostate cancer (even though he does not have any symptoms), what tests to have, and how often to have them.

The usual prostate tests include: Digital rectal exam: the doctor inserts a lubricated, gloved finger into the rectum and feels the prostate through the rectal wall to check for hard or lumpy areas.

Blood test for prostate-specific antigen (PSA): a lab measures the levels of PSA in a blood sample. The level of PSA may rise in men who have prostate cancer, benign prostatic hyperplasia (a non-cancerous enlargement of the prostate gland), or an infection in the prostate.

These tests will only determine if there is a problem with a man’s prostate gland. They cannot determine if the problem is cancer. Only a biopsy of a sample of prostate tissue can reveal the presence of actual prostate cancer.

 

Q. What nutrients help prevent or treat prostate cancer?

A. The prostate health nutrients, calcium D-glucarate, selenium, broccoli, green tea, maitake, and lycopene, each work in unique ways. Some help men’s bodies’ work more effectively some keep cancer cells from growing, while others actually kill prostate cancer cells. Let’s discuss each nutrient and how it works.

 

Calcium D-Glucarate

It is a troubling fact of modern life that we are continuously exposed to cancer-causing chemicals and toxins. These toxins come in part from contaminants in the food we eat and pollutants in the air we breathe. There are also “natural” toxins that are produced in our bodies. Excess hormones, such as estrogen and testosterone, can cause cancer when they are no longer needed. Cancer causing chemicals not only initiate cancer, but exposure to them can also cause existing cancers to grow bigger, stronger, and more deadly.

Our bodies do a fairly good job of eliminating some of these toxins before they can cause us harm. In the liver, the toxin is bound or attached to a chemical called glucuronic acid. The bound toxin is then excreted in bile and eventually eliminated as a waste product in the stool. However, yet another chemical, an enzyme called glucoronidase, can break this bond between the toxin and glucuronic acid. When this happens, the hormone or toxin is released back into our bodies, capable of causing us harm once more. The longer the toxins and excess hormones are in our bodies, the greater the chances they can make us seriously sick. Scientists have discovered that increased glucuronidase activity in the body is strongly associated with prostate cancer.

Fortunately, scientists have also discovered that a natural substance found in foods, calcium D-glucarate, can greatly reduce the activity of glucuronidase. Calcium D-glucarate helps our bodies keep the harmful toxins and chemicals bound to glucuronic acid. While CDG is found in fruits and vegetables, the amounts may not be sufficient to maintain effective levels to stop beta-glucuronidase. CDG has been shown in many experimental studies to significantly stop prostate cancer growth. Studies have shown that by taking calcium D-glucarate, our bodies and get rid of the toxic chemicals and excess hormones that might stimulate cancer formation.

 

Selenium

Selenium is an essential trace mineral fund in the soil. Both plant foods like oatmeal and meats that we eat, such as chicken and beef, contain selenium. How much selenium, however, is difficult to determine. This is because the amount of selenium in soil, which varies by region, determines the amount of selenium in the plant foods that are grown in that soil. Animals, too, will have varying levels of selenium in their muscle, depending on the amount of selenium in their feed. The actual selenium level in the grasses and grains that make up animal feed reflect the amount of the selenium in the soil where they grew.

A major antioxidant, selenium slows down aging, keeps our skin supple, and helps prevent dandruff. Selenium also keeps our blood vessels healthy and protects us from heart disease. However, some of selenium’s most powerful effects are on the prostate gland.

In a recent study, researchers recruited 974 men to take part in a large clinical trial to determine if selenium could prevent cancer. Half of the men were given selenium supplements and half were given a placebo. Researchers, who did know which group got the placebo, watched and recorded the men’s progress. The researchers were amazed to learn that selenium cut the rate of prostate cancer by 63%!

The results of this study were so impressive that it has led to many other studies of selenium and prostate cancer. In fact, researchers at the Arizona Cancer Center and the Arizona College of Public Health in Tucson are currently studying the effect of selenium on prostate cancer in four ongoing clinical trials.

 

Broccoli

Scientists have observed over for a long period of time, that men who eat lots of broccoli have a lower risk of getting prostate cancer. It seems that sulforaphane, a compound abundant in broccoli, is the secret ingredient responsible for this connection. Sulforaphane increases certain enzymes in the body, called phase 2 enzymes, which deactivate cancer-causing chemicals. In lab experiments, prostate cancer cells that were exposed to sulforaphane, the compound inhibited the growth of the cancer cells up to 80 percent.

 

Green Tea

There is a potent plant substance in green tea that is a very effective killer of prostate cancer cells. A recent study tested four common components of green tea and determined that one of these compounds, epigallocatechin gallate or EGCG, has a special affinity for prostate cancer cells. Scientists discovered that EGCG can stop the growth of prostate cancer dead in its tracks. The chemical structure of EGCG is very similar to substances in red wine and cruciferous vegetables, known cancer killers.

 

Maitake mushroom

For many years, maitake mushrooms have been linked to good health in those who eat them. Called “dancing mushrooms” (possibly due to their wavy, rippling appearance or possibly due to the little dance of joy mushroom hunters perform when they find them in the woods), maitakes contain an important compound called D-fraction.

A recent study at New York Medical College showed that maitake D-fraction destroyed 95% of human prostate cancer cells in lab experiments.

 

Lycopene

Some of the most exciting nutritional news in relation to prostate health involves lycopene. This carotenoid is found primarily in tomatoes, and men who eat lots of cooked tomatoes have very low rates of prostate cancer. Because promising preliminary reports demonstrate that lycopene can actually kill prostate cancer cells, there has been an explosion of lycopene and prostate cancer studies.

In one of these studies, 32 prostate cancer patients ate a pasta meal covered with three-fourths cup of tomato sauce every day for three weeks. Results showed their PSA levels dropped two points. Even signs of DNA damage dropped sharply. The ability of lycopene to drop these levels in just three weeks has impressed researchers and scientists worldwide.

 

Q. Do I have to take each nutrient separately?

A. While you can purchase each one of these nutrients and take them separately, all of these nutrients are available in prostate health formulas. Make sure the formula you buy contains calcium d-glucarate, lycopene, and selenium, broccoli standardized to contain a minimum of 125 mcg sulforaphane, green tea, and maitake mushroom extract. Standardized ingredients provide consistently effective nutrients.

 

Q. What else can men do to prevent prostate cancer?

A. Adopting a healthy diet, including eating 5 to 9 servings of fruits and vegetables every day, eating several servings of whole grain cereals and bread, and reducing red meat consumption to 2 or 3 servings per week has been shown to reduce the risk of all kinds of cancer. In addition, the recent lycopene studies suggest that a diet that regularly includes tomato-based foods may help protect men from prostate cancer.

Men 50 years and older should have a digital rectal exam (DRE) and PSA test each year. African-Americans and those at higher risk should begin at age 40. Talk with your health care professional to determine how frequently the test should be done.

 

Conclusion

This year doctors expect to find 180,000 new cases of prostate cancer is the United States and 37,000 men will die of it. Prostate cancer is the second leading cause of cancer death in men. But there is hope.

More cancers are caught early and new treatments might help make it possible for men to live long and healthy lives following their diagnosis. By taking a few simple steps, men diagnosed with prostate cancer can take charge of their lives and overcome much of the fear and anxiety that accompany a cancer diagnosis.

Growing Older, Feeling Better

 

Not long ago, when a man turned sixty-five, he became officially old – the best years of his life far behind him. The milestone meant his working days were done and if he was lucky, he might get four or five years to spend as he wished before illness and infirmity set in. It was simply expected and accepted that the older a man got, the sicker he got.

Well, not anymore. Today, a man age 65 is just as likely to be found hiking in the hills, running in a marathon, or even dancing in the streets than rocking in that proverbial front porch rocker. Because it’s becoming more and more evident that the older a man gets, the healthier that man has been.

Eating healthy, exercising, and kicking harmful habits (like smoking) can add years to a man’s life. Aging research is proving over and over again, that we can prevent and delay heart disease, cancer, diabetes, and Alzheimer’s disease – the major causes of disability and death in men over 50.

Now, it’s very true that good clean living from early on is preferable to sixty five years of bad habits and five years of good. But it’s also true that it’s never too late for men to make changes and vow to take better care of themselves. And one of the easiest and most effective ways men can improve their health is the addition of high quality nutritional supplements.

In this issue of Ask the Doctor, we’ll talk about specific dietary supplements that have been scientifically shown to improve the health of men over fifty, prevent the diseases that often strike at this crucial time in men’s lives, and actually slow the aging process.

 

Q. I just turned 50 and I’d like to begin taking nutritional supplements, but they seem so confusing. Where should I begin?

A. Many men feel the same way. There are literally hundreds and hundreds of nutritional supplements on health food store shelves. Figuring out which supplements provide the best health benefits for a 50+ man can be overwhelming.

The best foundation supplement is a high quality multivitamin. Research is repeatedly finding that even very healthy men who take daily multivitamins can significantly improve their health. In fact, an article published in the Journal of the American Medical Association (JAMA) recommends that all adult Americans take a vitamin supplement. Look for solid doses of vitamin supplement. Look for sol doses of vitamins and especially minerals. Multivitamins designed to be taken once a day are often woefully deficient in calcium, magnesium, and potassium. The only mineral a man should avoid is supplemental iron. Iron should only be in formulas for women prior to menopause. Men over 50 get all the iron they need from food and too much iron can cause health problems.

 

Look for men’s multivitamins that contain lycopene in the formula. Lycopene is the pigment that makes tomatoes red. The redder the tomato, the more lycopene is present. Numerous studies have shown that when men have high lycopene levels in their blood, they have a much lower risk of heart disease, age-related macular degeneration (a leading cause of vision loss) and prostate cancer.

 

Other important considerations are antioxidant blends, especially fruit- and tea-derived extracts; ginseng for energy and stamina; and digestive enzymes to aid in absorption and compensate for age-related decreased enzyme levels.

 

In fact, years of research has shown the foods a man chooses to eat (or not to eat) can have a profound impact on the health of his prostate gland. Because of this close nutritional link, prostate cancer may be the most preventable type of non-smoking related cancers.

 

Q. Aside from taking a quality multivitamin for general health, what nutritional supplements prevent and treat prostate cancer?

A. Six vital and all-natural nutrients can prevent prostate cancer from developing and even help fight the disease.

 

Calcium D-Glucarate

When men are exposed to excess levels of hormones, their risk of prostate cancer increases. A natural substance found in fruits and vegetables called calcium D-glucarate (or CDG), helps men’s built-in detoxification systems get rid of these harmful excess hormones.

 

Selenium

This antioxidant has powerful effects on the prostate gland. In a recent study, researchers recruited 974 men to take part in a large clinical trial to determine if selenium could prevent cancer. The researchers found that selenium cut the rate of prostate cancer by 63%!

 

Green Tea

Green tea is the most widely consumed liquid in the world, after water. Men in China and Japan have been drinking it for centuries. They also have very low rates of prostate cancer. Research has discovered that potent plant substance in green tea called epigallocatechin gallate, or EGCG, can stop the growth of prostate cancer cells dead in their tracks.

 

Maitake Mushroom

For many years, maitake mushrooms, or dancing mushrooms, have been linked to good health in those who eat them. That’s because maitakes contain an important compound called D-fraction. A recent study showed that maitake D-fraction destroyed 95% of human prostate cancer cells in lab experiments.

 

Lycopene

Promising preliminary reports demonstrate that lycopene can actually kill prostate cancer cells, so there has been an explosion of lycopene and prostate cancer research.

 

Q. What exactly happens to men’s hormones as they get older?

A. Just as women experience significant hormonal changes as they age, so do men. In fact, the term andropause has been used to describe men’s mid-life changes. Similar to menopause in women (where the decline of estrogen causes a myriad of symptoms), andropause in men signals the slow decline of testosterone, the chief sex hormone in men. While estrogen levels decline faster and more abruptly in women than testosterone levels do in men, testosterone decline can cause a number of unpleasant symptoms. These include abdominal weight gain, hair loss, reduced energy and sex drive, heart disease, and prostate enlargement. Whether a man labels these age-related changes as andropause or just the consequences of aging, most men will unfortunately experience some or all of them as their birthdays mount.

 

Q. So, is there a supplement that can give me the hormone level of a 20 year old?

A. Sadly, no, at least not yet! But there is a nutrient that can help the testosterone in a man over fifty “behave” more like a younger man’s testosterone.

 

A study that took place at the Fred Hutchinson Center in Seattle found that men who ate three servings of cruciferous vegetables – broccoli, cauliflower, or Brussels sprouts – every day had a 48 percent lower risk of prostate cancer. It seems a cruciferous plant chemical called diindolylmethane (DIM) that’s formed when broccoli is eaten, is the substance responsible for this impressive prostate cancer prevention. Since not many men could be persuaded to ea t broccoli for breast, lunch, and dinner every day researchers tried to extract DIM from these vegetables and make into a nutritional supplement. After many years of trying, scientists finally discovered a stable, all natural, and absorbable from of DIM.

 

The secret of DIM’s prostate cancer prevention is its ability to metabolize estrogen. While estrogen is generally thought of as a “female” hormone, a precise ratio of testosterone-to-estrogen is needed to maintain a man’s healthy sexual response, effective sexual function (erection of the penis and intercourse), strong bones and muscles, viable sperm, and a well-functioning prostate gland. As men enter their fifties, this ratio begins to change.

 

When men take DIM, however, their estrogen metabolism improves, testosterone metabolism accelerates, and the unwanted conversion of testosterone into estrogen is eliminated. This results in higher testosterone levels, similar to those seen in young men. As a result, DIM may speed weight loss, reduce prostate gland enlargement (benign prostatic hyperplasia or BPH), and help men over 50 feel stronger and leaner.

 

Some supplements on the market today contain indole-3-carbinol (I3C), a precursor to DIM. However, I3C is unstable and requires activation in the stomach to be converted into DIM. This means I3C must be taken at a much higher amount and can undergo unpredictable and undesirable chemical reactions in your stomach and colon. DIM is by far the preferred supplement.

 

Q. What is saw palmetto? Does it reduce symptoms of Benign Prostate Hyperplasia (BPH)?

A. Yes it does and very effectively too. Saw palmetto is a small palm tree native to Florida and North Carolina. The tree’s dark red berries contain many beneficial compounds. Nutritional supplements that contain saw palmetto are highly effective in the treatment of BPH.

 

The prostate gland is about the size of a walnut and is located below the bladder and in front of the rectum. It wraps around the upper part of the urethra and its primary job is the production and storage of semen, the milky fluid that nourishes sperm. BPH is one of the most common health conditions in older men. Half of all men aged 40-60 and more than 90 percent in men over 80 have BPH. BPH causes the prostate gland to enlarge, putting pressure on the urethra.

 

Men have trouble starting or maintaining a stream of urine, find they can’t completely empty their bladders, and have to urinate frequently, even during the night. They may also have episodes of uncontrollable dribbling or complete loss of urine. BPH is caused by the conversion of estrogen to a very potent form of testosterone called, dihydrotestosterone (or DHT). When prostate cells are exposed to DHT, they multiply in number and get much larger.

 

BPH rarely improves. It most often remains the same for years or gets gradually worse. The need to continually urinate, interrupted sleep, dribbling, and loss of urine can significantly interfere with a man’s quality of life. Prescription medications that have been developed to treat BPH are only partially effective. And surgical removal of the prostate gland may result in even more persistent urinary incontinence and the inability to achieve an erection (ED).

 

However, saw palmetto berry extract relieves the symptoms of BPH by inhibiting the production of DHT. And, in study after study after study, saw palmetto caused none of the side effects that happen with prostate surgery or medications.

 

Q. There seem to be plenty of ads for supplements that claim they make men into Sexual Superheroes. Is there an “honest” nutritional supplement to help me sexually?

A. That’s a very good observation. And yes, there are honest nutritional supplements for men’s sexual health.

 

Sexual intimacy is an important, complex, and lifelong need. It makes us feel better physically and mentally and adds to our sense of security, belonging, and self-esteem. But just like other changes that happen to men as they get older, men’s sexual response most often changes, too. Declining testosterone levels, changes in blood flow to the penis, certain medications that older men are prescribed, and the presence of diabetes or heart disease can all affect men’s ability to engage in sexual activity.

 

When men have a chronic inability in obtaining and/or maintaining an erection, it’s called erectile dysfunction (ED). While ED is not an inevitable part of getting older, it does occur more frequently as men age. About 5% of 40-year-old men have ED, but more than 23% of 65-year-old men have difficulty maintaining erections.

 

The development of prescription medication Viagra (sildenafil citrate) has revolutionized ED treatment. When a man is sexually stimulated, Viagra helps the penis fill with enough blood to cause an erection.

 

Like all medicines, Viagra can cause some side effects, including headache, flushing of the face, and upset stomach. But because Viagra is a prescription medication, it requires a visit to a licensed healthcare practitioner. For many men, telling anyone (even a professional) that they are having trouble getting or keeping an erection is simply too embarrassing. Viagra is also fairly expensive and many older men do not have prescription drug health insurance.

 

These reasons may explain that while an estimated 30 million men in the United States – 10% of the male population – experience chronic ED, as few as 5% of men with chronic ED seek treatment.

 

Not every man can take Viagra, either. Men who use nitrate drugs, often used to control chest pain (also known as angina), must not take Viagra. This combination can cause their blood pressure to drop to an unsafe or life-threatening level. Men with serious liver and kidney problems who take Viagra must be monitored closely for possible serious side effects.

 

The good news is there is a nutritional supplement that’s formulated with vitamins, herbs, and glandular products that targets male sexual organs. The formula contains vitamin E, liver fractions, wheat germ, beta-sitosterol, and herbal extracts of muira puama, Mexican damiana, saw palmetto, cola nut, ginseng, and ginkgo biloba.

 

Vitamin E is a powerful antioxidant and men’s testicles, adrenal glands, and pituitary glands need high levels of this fat-soluble vitamin for proper functioning. Extracts of Muira puama, Mexican damiana, and cola nut have been studied for their beneficial effects on male hormones.

 

Study of ginkgo in sexual response came about when a patient in a nursing home who was taking the herb for memory enhancement noted that his erections were improved. Since then, study of ginkgo has shown it helps blood flow to the penis. Sexual response research in one ginkgo study showed that 76% of men taking ginkgo experienced improved sexual desire, erections, and orgasms.

 

While other nutritional supplements sold to improve sexual stamina often make outrageous claims, reputable manufacturers rely on science and results to sell their products.

 

An important note

Most often sexual problems are simply part of the aging process. They can also be signs of serious health problems. If the use of nutritional supplements for two months does not improve your erections, you do need to see your healthcare practitioner. Almost all practitioners understand how difficult this problem is for men to discuss and are experienced in getting the information as quickly and as painlessly as possible.

 

Conclusion

No man has the power to stop the passage of time. But every man has the power to make aging more healthy and less harmful. Research conducted on men who live to be 100 and beyond, has determined that those who reach extreme old age do so by avoiding ill health, rather than by enduring it. As I like to remind my patients, “Age is not determined by years, but by function.” And it’s never too late for men to detour around the major illnesses of getting older. With good nutrition, healthy habits, and high quality nutritional supplements, the best years of a man’s life can absolutely and positively be those he spends in his 70s, 80s and even his 90s.