Search Term: " cyanocobalamine "
Difference between Vitamin B-12 Cobalamine
January 06, 2014 01:58 PM
Vitamin B-12 occurs in many formations.
The different formations of vitamin B-12, based on the functional group,is called cobalamine. The naturally occuring form in the human body is the dibencozide while the most common supplemented forms being the cyanocobalamine and methylcobalamine.
Differences between cyanocobalamine and methylcobalamine:
1. cyanocobalamine has the presence cyanide ligand on the cobalamine and it is very stable and has a longer shelf live.Methylcobalamine, on the other hand, is an active cobalamine and has methyl ligand present in it.
2. cyanocobalamine is converted into methylcobalamine in the body. The glutathione present in the human body removes the cyanide ligand and replaces it with methyl group. cyanocobalamine is not recommended for persons who smoke as cyano group fails to detach in persons who intake tobacco. And hence the intake of cyanocobalamine can be fatal for smokers. It is also not recommended for those having liver failure since the glutathioneis formed in liver and hence if there is no glutathione the cyanide ligand cannot be detached and can pose threat to the body.4. At 1mcg dose cyanocobalamine is absorbed at 49.2% while methylcobalamine at 44.4%5. At 5 mcg dose cyanocobalamine is absorbed at 20.4% while methylcobalamine at 18.8%6. At 25 mcg cyanocobalamine is absorbed at 5.6% and methylcobalamine at 6.1% This indicates that cyanocobalamine is absorbed in the body better than methylcobalamine.The difference in the absorption can be attributed to the mass and the molecular structure of cyanocobalamine.cyanocobalamine is cheaper than methylcobalamine and it has prolonged shelf life compared to other cobalamine forms. It appears as crystals synthesis and is red in color. Although the food rich in vitamin B-12 is enough for the body to meet the daily requirements, deficiency of this vitamin leads to disturbance in the sleep pattern, feeling of tingling in the body parts, numbness, etc