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Do you need to regulate hormones ? Experience Chaste Berries Powerful Effects Darrell Miller 9/17/16
Can Melatonin Increase Prolactin? Darrell Miller 12/22/12
Can Chaste Berry Help With PMS? Darrell Miller 8/18/12
Chaste Berry a Women Herb Darrell Miller 2/8/12
Natural Hormone Balance for Women Darrell Miller 12/25/07
Is Wild Yam Natures Progesterone? Darrell Miller 11/15/07
The Healing Power Of Borage Oil’s GLA Darrell Miller 11/13/07
Remifemin symptomatic relief, scientifically supported* Darrell Miller 8/26/06
Comprehensive Prostate Formula-the Clinical Studies Darrell Miller 10/13/05
The Natural Man Darrell Miller 6/10/05




Do you need to regulate hormones ? Experience Chaste Berries Powerful Effects
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Date: September 17, 2016 09:58 AM
Author: Darrell Miller
Subject: Do you need to regulate hormones ? Experience Chaste Berries Powerful Effects

Would you believe that a simple berry could be the solution to hormone normalization and regulation? The Chaste berry has been shown to treat suffering from symptoms of menopause, menstrual irregularities, pre-menstral syndrome, and infertility. However, Chaste berries benefits do not end with women as the berry has also seen use as a natural way to balance hormones in men and may actually prevent prostate cancer.

Chaste berry, also known as vitex, has the ability to regulate and stimulate anterior pituitary functions and has been shown to restore normal estrogen to progesterone levels in women. This is accomplished by attaching to dopamine receptors and decreasing output of prolactin. It is this process that allows Chaste berry to treat the multitude of different hormonal issues that it does and ultimately regulate and normalize hormone levels.

In conclusion, there are many different uses for Chaste berry when it comes to hormonal health. For women the berry has shown successful use as a treatment for PMS pains, fertility challenges, and abnormal menses. In men, Chaste berry has been used to prevent prostate cancer and balance hormones. Chaste berry has also been indicated to effectively treat acne in both male and females. Who would’ve thought you could get all that from one little berry?

References:

//www.organicauthority.com/health/balance-hormones-naturally-with-chasteberry.html

//www.blossomclinic.net/2012/01/04/chaste-tree-berry-vitex-a-girls-best-friend-2/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3296)


Can Melatonin Increase Prolactin?
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Date: December 22, 2012 11:28 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can Melatonin Increase Prolactin?

What Is Melatonin?

Melatonin chemically known as N-acetyl-5-methoxytryptamine is a naturally occurring compound normally found in microbes, plants and animals. Many of the biological effects that are associated with this product are usually produced via activation of the melatonin receptors. However, there are others which are as a result of its powerful and pervasive antioxidant nature.

Melatonin and Sleep

Melatonin also plays a vital role in maintaining natural cycle of wakefulness and sleep. There are some controversies over whether melatonin can increase prolactin or not.

Can Melatonin Increase Prolactin?

Studies that have been conducted recently by medical experts have shown that melatonin can cause an increase in the level of prolactin. Prolactin refers to a hormone which usually plays a vital role in regulating menstrual cycle and in producing milk. It is thus advisable that women who normally experience mood changes or who are in depression related to menstruation should avoid it.

In conclusion, it is my sincere hope that the question on if melatonin can increase prolactin has been answered.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2772)


Can Chaste Berry Help With PMS?
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Date: August 18, 2012 08:22 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can Chaste Berry Help With PMS?

Chaste Berry

Chaste berry is a kind of berry that grows in the Mediterranean region, and has many useful medical applications. Chaste berry is essentially a herb, belongs to the Vitex species, and is characterized by purple colored flowers that grow on it. It is grown widely in many parts of Africa. The plant grows up to 5 meters in height. Chaste berry has been in the mainstream media ever since studies showed that it helped women a lot in dealing with pre menstrual syndrome (PMS). While is has many other uses, both medical and non-medical, this particular functionality of chaste berry has been extensively noticed, as every woman in the world suffers from PMS quite a few times in their lives.

How is chaste berry useful with PMS?

Studies have shown by clinically proving that chaste berry helps women deal with PMS in many ways. A few of them are listed below:

Chaste berry helps keep the pituitary glands in check by acting upon prolactin secretion. Prolactin is a secretion of the pituitary gland that is associated with the breasts becoming tender in women during PMS. Thus by keeping it in check, one of the biggest causes of stress that women go through during PMS is reduced.

Chaste berry consumed in the tablet form has been proven to significantly reduce many of the PMS symptoms and effects that women go through. It has been concluded that most of the effects that chaste berry has with regards to PMS are sub-results of the bigger result, namely reduced prolactin secretion.

Unlike other clinically produced medicine, chaste berry is nature's own medicine to help cure the PMS blues, and it does a great job. As a matter of fact, the exact procedure that happens inside the body after consuming chaste berry is not comprehensible enough to the general audience, but the results speak for themselves.

Chaste berry extracts are available as tablets, and the effective dosage is one 20 mg tablet, up to three times a day. Consult your doctor for the exact prescription; this is just the general estimate. If you choose to take the drops, around forty drops per day will do.

What other uses does chaste berry have?

Chaste berry has many other uses, apart from belong with PMS.

Some of them are:

Chaste berry has been proven to help in prevention and control of prostate cancer. Anti-tumor behavior of chaste berry on the cancerous cells has been observed, thus establishing the fact that chaste berry helps in prostate cancer.

Chaste berry has also successfully helped in breast pain, which is medically called mastalgia. The effects are well researched and documented.

With relation to controlling the prolactin secretion as stated above, chaste berry ultimately helps prevent and control Hyperprolactinaemia, which is essentially the presence of the hormone in large quantities in the blood. This can sometimes lead to problems in breast milk production, and breast feeding.

The best part about chaste berry is that it has absolutely no documented side effects. The only piece of advice associated with chaste berry is that it should not be consumed during pregnancy, as might cause some complications later on. All said and done, chaste berry does help with PMS, no doubt about that.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2674)


Chaste Berry a Women Herb
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Date: February 08, 2012 11:51 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Chaste Berry a Women Herb

Other names of Chaste Berry- Monk's pepper, Chaste-tree Berry

Chaste Berry is the fruit found on Chaste tree which is botanically known as Vitex. Chaste tree is a decidous tree that grows in a well-drained, acidic soil in full sun. Vitus agnus castus or Chaste Berry is a native to the Mediterranean and Central Asia but now is grown throughout the world. The tree belongs to Verbanaceae family and can grow to a height of 22 feet. It was traditionally used by men in ancient Greece and Rome to reduce sexual desire, treat menstrual disorders and other hormonal problems and as an anti-microbial agent against infections. It is also known as 'Women's Herb' as it regulates hormonal imbalances and promotes women reproductive health. Aside from its medicinal use, it was used as a peppery condiment. Some of the constituents included in Chaste Berry fruit are flavonoids (casticin, orientin, isovitexin, kaemferol), glycosides (aucubin and agnuside) and essential oils (linalol, sabinene, pinene and limonene). These phytohormone compounds help in regulating the female hormones production and normalising testosterone and progesterone activity.

Effects of Chaste Berry:

ChasteBerry controls and regulates overall female reproductive system.

1. It helps to manage Pre-Menstrual Syndrome: Pre-Menstrual Syndrome is associated with several uncomfortable symptoms, ranging from mood swings to fatigue and hot flushes. Chaste Berry is known to be rich in progesterone that helps to ease out the disturbing symptoms of Pre-Menstrual Syndrome.

2. It helps to normalize menstrual irregulaties: Imbalance in prolactin levels in the body can lead to various complications in women such as amenorrhoea (absence of periods), breast tenderness and reduced milk production in lactating mothers. Chaste Berry balances natural production of prolactin hormone in the body and effectively treats menstrual irregularities and other symptoms such as tenderness of breast and reduced milk secretion.

3. It treats menopausal discomforts: Some women experience dicomfort and other menopausal symptoms that affect their daily routine life. The hormone regulating properties of Chaste Berry help in easing menopausal symptoms such as mood swings and hot flushes and several other physical symptoms associated with hormone deficiency during menopause.

4. It improves overall female reproductive health: Chasteberry has been found to be effective in treating fibroid cysts especially of smooth muscle. It also reduces heavy bleeding associated with perimenopause.

5. It helps in treating Hormonal acne: Hormonal acne are due to imbalance in androgen hormone levels. Increased androgen levels in the body leads to excessive sebum production that causes acne. This wonder herb regulates the androgen levels in the body and thereby helps in treating moderate and light acne. Another way in which this herb prevents acne formation is its anti-bacterial property. The bioactive essential oils present in Chasteberry have anti-bacterial properties that prevent the survival of bacteria. Chaste Berry contains linoleic fatty acid which is responsible for regulating sebum production.

Chaste berry modulates the hormone prolactin with the neurotransmitter dopamine. The active ingredients such as polyphenols in the herb indirectly affects hormones and neurotransmitters and regulate the hormones.

Chaste berry herb is a safe and natural treatment for many women related problems.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2564)


Natural Hormone Balance for Women
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Date: December 25, 2007 11:18 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Natural Hormone Balance for Women

The majority of women are affected by moderate-to-severe menopausal symptoms and premenstrual syndrome (PMS) at some point in their life. PMS that is clinically diagnosed consists of symptoms that are so severe and pervasive that careers, social interactions, and family lives are negatively affected. This occurs in eight to twenty percent of women in the Western world. Menopause and PMS are both characterized by a severe fluctuation or major falling of the female hormones estrogen, progesterone, and prolactin. Since many examples of women who are barely affected by natural changes exist, it can be logically inferred that female hormones are capable of remaining close to balanced, while others experience hormones that swing abruptly from one extreme to the next, causing severe mood swings. Although changes in hormone levels are the reason menopause and PMS occur, women do have some control over the severity of their symptoms.

There are many natural approaches to hormone balance along with other medical interventions that can be used either separate or together. However, one must remember that women are biologically programmed to have multiple children, which therefore, would limit the number of menstrual cycles in a lifetime. Additionally, women are now living thirty years past menopause, an experience that is relatively new. Also, a lot of the pain and anguish that is associated with menopause and PMS is actually related to obesity, high-calorie eating habits, and inactivity. Normal body weight and regular exercise often leads to mild or inconsequential PMS.

In 2002, estrogen and progesterone hormone replacement therapy, which is the standard treatment for menopausal symptoms, came under scrutiny after the publication of research that found that supplementation of estrogen significantly increases the risk for breast and ovarian cancer. Supplementing estrogen also does not protect against cardiovascular disease. As a result, US-dispensed prescriptions for estrogen declined from ninety-one million in 2001 to fifty-seven million in 2003. It has been found that a lot of the excess risk for breast and ovarian cancer was due to prescriptions being refilled indefinitely instead of hormone replacement therapy only being used at the onset of menopause. Additionally, supplemental estrogen was not paired and balanced with progesterone, causing a greater risk. Either way, the door to natural alternatives was opened wide, especially for those patients who have a family history of reproductive cancer. Natural therapy for menopause and PMS is based upon phytoestrogens.

Phytoestrogens are plant compounds that contain chemical structures which resemble estrogen. These plant compounds can exert weak estrogenic or antiestrogenic effects. Isoflavones from legumes such as soybean, red clover, licorice, as well as lignans like flaxseed and milk thistle are the most common and familiar phytoestrogens. Black cohosh has been shown to have antiestrogenic effects only. Phytoestrogens have been proven to reduce the risk for estrogen-dependent breast, uterine, and ovarian cancers as well as hot flashes, night sweats, and sleep disturbances. Although phytoestrogens do a good job at protecting women from symptoms of excess estrogen, phytoestrogens cannot replace estrogen when there isn’t enough. They don’t help with vaginal wall atrophy and dryness, thinning hair, lack of sexual desire, menopause-related urogenital itching, or infertility. For the best results, supplements of soy and red clover isoflavone should be taken 2-3 times daily. Although there are no herbal alternatives that actually raise levels of estrogen, natural medicine such as dong quai, licorice, milk thistle, ginseng, pycnogenol, and pollen for menopause and calcium, magnesium, B6, chastre tree, dong quai, and ginseng for PMS can balance existing female hormones and provide relief from symptoms.

--
Vitanet, LLC ®

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Is Wild Yam Natures Progesterone?
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Date: November 15, 2007 07:20 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Is Wild Yam Natures Progesterone?

Dioscorea villosa, commonly known as wild yam, is a tuberous vine native to North America and parts of Central America. It was used by the Mayan and Aztec civilizations for pain relief and birth control and has also been given the names colic root and rheumatism root, demonstrating this early use of the plant. However, whether it is nature’s progesterone or not is another question that requires close analysis.

These Central American civilizations, of course, did not understand the reason why they were effective. Some of the symptoms treated can be caused by the menopause, and the wild yam is believed to contain natural forms of progesterone that can alleviate some of the adverse effects of the menopause on the body. Like most plants, they also likely act as anti-inflammatories, so relieving the pain of rheumatoid arthritis and other inflammatory conditions.

Like any natural remedy, wild yam had its adherents and its detractors, though in recent years the plant has been used as the raw material for the production of cortisone and a form of progesterone: or at least so it is claimed, so let’s have a closer look at these claims and determine whether or not wild yam is indeed nature’s progesterone.

The human body uses organic compounds called hormones to regulate many of the chemical activities of the body. The hormones catalyze the chemical reactions and changes needed for the proper functioning of our bodies. Hormones are produced in small chemical factories dotted throughout our body called glands. Each gland is devoted to producing a specific hormone, or a range of them, and each hormone is designed for a specific purpose.

Each has an associated hormone ‘receptor’ at their targeted destination that fits the hormone like a jigsaw piece. When it turns up, the hormone attaches to the receptor and the reaction proceeds. That might be the initiation of energy production in cells, the activation of certain genes or even the stimulation of hair growth by the follicles or of the libido and the natural desire to procreate.

Hormones are manufactured from only three constituents: proteins, amino acids and cholesterol, and the steroidal sex hormones are created from cholesterol. Therefore, don’t reduce your cholesterol level too much!

Prior to puberty, all of the sex hormones are manufactured by the adrenal glands, and after puberty by the ovaries in women and the testes in men. Progesterone is produced initially, and is then used as the building block for all the other sex hormones (hence the prefix ‘pro’). In women these are the estrogens and in males the androgens. Progesterone is made from the start of the menstrual cycle, and after day 12 they have reached a high enough level to halt ovulation. Progesterone levels continue to rise for about 8 days, and then if fertilization has not occurred, the progesterone levels trigger menstruation, and the lining of the womb is detached and expelled.

During certain phases of the menstrual cycle, the levels of the hormones estrogen and progesterone drop off, although the exact reason for the many and varied symptoms of pre-menstrual syndrome (PMS) are still unknown to a large extend. There appear to be several contributing factors, though estrogen and progesterone certainly appear to be two of the major ones. We shall concentrate here on the progesterone factor because that is what wild yam is claimed to address.

Although the main function of progesterone is to generate estrogen and testosterone, to restore the libido after menstruation, and maintain the integrity of the lining of the uterus and aid in gestation, it has many other purposes such as in thermogenesis (burning of body fats), protection against osteoporosis and is also believed to have a natural anti-depressant action. These are all supported by the symptoms that appear when the body is low in progesterone levels: depression, sudden increase in body fat, mood swings, loss of sex drive and a susceptibility to weak bones if the deficiency is long-term.

In other words, women that usually suffer from PMS, also generally suffer low progesterone levels. It is believed in some quarters that a progesterone deficiency causes an excess of estrogen that leads to these symptoms in addition to heart disease. No one really knows for sure, but a deficiency of progesterone seems to be the determining factor.

Women with menstrual problems continue to be issued with prescribed synthetic progesterone even though they do not have the same effect as natural progesterone. They can also lead to some unpleasant side effects such as fluid retention, strokes, jaundice, blood clots and depression: some of the symptoms it is intended to alleviate. Some take borage or evening primrose oil for the GLA that helps some of the effects, but this is taken to counter the over-production of the hormone prolactin in some women prior to menstruation, not a deficiency of progesterone.

Wild yam does not cause these symptoms, and is claimed by many to be very effective in alleviating the symptoms of PMS. The problem with the artificial forms of progesterone is that the liver’s job is to destroy foreign hormones, and send them to the digestive tract for expulsion. Natural hormones are not affected in this way, even if they come from a non-human source.

The chemical diosgenin in wild yam is very similar in structure to progesterone, and is believed to be the active principle. It is claimed that it can be used to produce not only progesterone but also other related hormones. However, some medical authorities and practitioners dispute this claim, and there is still a question as to how wild yam works. Because it does work, many people swear by it and claim that they could not live without it.

This is especially true of those that suffer from the more severe effects of PMS, and since wild yam does not work for everybody, it could be connected with the severity of the condition and the symptoms. Whichever is true, there appears to be little doubt in the eyes of those that use it as a cream that wild yam is indeed nature’s progesterone.

--
Natures Progesterone

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The Healing Power Of Borage Oil’s GLA
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Date: November 13, 2007 10:22 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Healing Power Of Borage Oil’s GLA

Borage is otherwise called the starflower, and the borage oil extracted from its seeds is very rich in GLA, gamma linolenic acid, a polyunsaturated fatty acid also obtainable from evening primrose oil. Borage, however, is richer in GLA, and is therefore a more economical source that the evening primrose.

A shrub, frequently seen in gardens, borage has historically been used as a salad food, and also in soups, and borage honey is prized in many quarters. Now, however, its main use is for the GLA extracted from the seed, which provides a higher yield of GLA than any other source. Borage seed oil contains up to 25% GLA, compared to the 17% from blackcurrant oil and 9% from evening primrose oil.

The importance of GLA to the body’s biochemistry is inestimable, and cannot be overstated. It is not so much the GLA that is so important, but the prostaglandin to which it is converted in the body. Prostaglandin E1 is a hormone-like substance that plays a part in many of the biochemical and metabolic processes of the body. Examples include the control of the immune system and inflammatory response, some kidney functions, and the tone of the arterial muscles, so important in the health of the cardiovascular system.

A good fatty acid metabolism benefits some very important aspects of our health such as maintaining a good blood pressure, low cholesterol levels, preventing inflammatory and immune system conditions such as arthritis, allergies and some skin diseases such as eczema and psoriasis, and also improving the strength of the keratin-dependent tissues such as our nails and hair.

A deficiency in essential fatty acids also seems to stimulate the overproduction of a hormone in women called prolactin that can lead to the severe mood changes commonly referred to as pre-menstrual syndrome, or PMS. GLA appears to have a beneficial effect in the treatment of PMS, and some other conditions such as breast discomfort.

Gamma linolenic acid is created in the body from linoleic acid, of which there is a plentiful supply in margarine, vegetable oils and many processed foods, but there is a problem. Fatty acid molecules come in different isomeric forms, in which although the chemical is the same, the geometry or ‘stereochemistry’ is different. The healthy form is the ‘cis’ formation, and the other is the ‘trans’ stereoisomer. The trans fatty acids are formed by hydrogenation of oils to make them semi-solid, and more suitable for spreading. This hydrogenation process causes an irreversible change in the geometry of the fatty acid that can block the conversion of linoleic acid to GLA in the body.

Hence, although most of the western population has more than sufficient linoleic acid in their diets, many who eat an excess of trans fats have a deficiency of GLA. Some B vitamin deficiencies and a deficiency in certain minerals exacerbate this situation, and a gamma linolenic acid supplement is needed. Additional to this, the enzyme responsible for the conversion, delta-6-desaturase (D6D) can be affected by many modern environmental factors such as smoking, stress, alcohol, excessive animal fat consumption and even excessive linoleic acid consumption. The solution to all of this is GLA which does not require any enzymes for its creation, and supplemental GLA from any source can immediately take part in the biochemical pathway to the creation of the prostaglandin eicosanoids.

GLA provides the means and the resultant prostaglandins carry out the job of regulating the hormonal activity within human biochemistry. Prostaglandins help to regulate the function of many of the cells in the body, such as the smooth muscle cells of the arteries and veins that cause constriction or dilation, and on the stickiness of blood platelets causing their aggregation. They are important in the regulation of such functions as blood clotting, fluid balance and the production and balance of hormones. The anti-inflammatory properties of prostaglandin E1 are very important to the way that the body reacts to breaches by foreign invaders, and it is also thought to act to thin the blood and cause dilation of blood vessels, hence its effect in lowering the blood pressure.

So what does this mean to you, apart from the effects of the fatty acid on PMS? Borage oil can be used to treat a large number of different symptoms associated with a shortage of GLA and prostaglandin E1, and here are a few of the conditions for which a GLA supplement has been found beneficial.

A deficiency in GLA and other essential fatty acids can lead to loss of bone mass and subsequent osteoporosis and it is thought that fatty acids help the absorption of calcium by the digestive system, and to increase its deposit in bones. It can be used to increase bone mass and density and therefore strengthen the bones of those affected by osteoporosis. This is partially due to the hormone regulatory effect GLA has on the body.

Allergies appear to be very personal responses by the immune system to specific substances, and while borage oil has proved beneficial in a few allergies, and prostaglandins are known to regulate the activity of the immune response, the effectiveness of GLA treatment for allergies has been mixed. There is evidence that it can affect some cases, but not most.

GLA from borage oil can reduce the swelling and pain of rheumatoid arthritis, and helps to ease morning stiffness. Its effectiveness seems mixed, and you should try it for two or three months to determine if it helps you personally. Be careful, however, since some believe that it might react with some of the non-steroidal anti-inflammatory drugs (NSAID) used to treat this condition. Ibuprofen is one, so check with your physician before trying it.

If you suffer from high blood pressure, borage oil used in conjunction with Omega-3 fish oils might lower it, though more research is needed. There is a belief that the GLA is not the active agent here since Omega-3 oils are known to help to reduce hypertension, though the effect of prostaglandins on the factors that can reduce blood pressure is inarguable.

The healing power of borage oil should not be underestimated, and it has been used for centuries in folk medicine to treat many conditions, especially those that science has found to be caused by the immune system and the inflammatory response. Borage oil can be found at any Health Food Store.



--
Discount Borage Oil

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Remifemin symptomatic relief, scientifically supported*
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Date: August 26, 2006 02:41 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Remifemin symptomatic relief, scientifically supported*

Remifemin

 

Symptomatic Relief, Scientifically Supported*

 

The only RemiSure black cohosh

 

Unique to Remifemin® - Exclusive standardized isopropanolic black cohosh extract, subject of over 90 scientific papers.

Proven Effective – The most clinically studies natural intervention for menopausal symptoms with over 40 years of use worldwide*

 

  • Relief from hot flashes, night sweats, mood swings, irritability, and related occasional sleeplessness*
  • Particularly in women in early stages of menopause*

 

Safe – Completely hormone free

 

  • Works naturally without plant-based estrogens that can affect breast and uterine cell growth
  • Can be used safely by women with a history of breast cancer who cannot take estrogen

 

Efficacy

STUDY DESIGN

BENEFITS

DOSAGE

REFERENCE

1. Twelve-week, randomized, multicenter, double-blind clinical trial comparing the efficacy and tolerability of Remifemin® in the treatment of climacteric complaints compared with placebo.  The primary efficacy measure was the change from baseline on the Menopause rating Scale 1.

·          Remifemin® effectively relieved menopausal symptoms, particularly in women in the early stages of menopause*

·          Most significant reduction was in hot flash occurrence*

·          Other symptoms resulting in significant reduction include: psyche (irritability and memory), and atrophy (vaginal dryness)*

·          No significant adverse effects reported

40mg qd

Osmers R, et al. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms.  Obstet Gynecol. 2005 May; 105(5):1074-83.

2. A review of 29 randomized controlled trials of complementary and alternative therapies for menopausal symptoms.

·          Black cohosh is one of the only herbal remedies shown to be effective for menopausal symptoms, especially hot flashes*

 

Kronenberg. F. Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med. 2002 Nov 19;137(10:805-13.

3. Four-week, pilot study, open clinical trial of menopausal women with hot flashes, including women with a history of breast cancer.

·          Remifemin® reduced mean daily hot flash frequency by 50% after 4 weeks*

·          Overall, participants reported less trouble with sleeping, less fatigue, and fewer night sweats* 

·          No participants stopped therapy because of adverse effects

40mg qd

Pockaj BA, et al. Pilot evaluation of black cohosh for the treatment of hot flashes in women.  Cancer Invest. 2004;22(4):515-21

4. Double-blind study involving the use of Remifemin® in women ages 43 to 60 with menopausal complaints lasting 6 months.

·          Majority of woman saw a 70% reduction of physical and emotional symptoms after 12 weeks, including hot flashes, night sweats, mood swings, and irritability*

·          Significant improvement was noted after 4 weeks use*

·          Remifemin® works safely and effectively to treat menopause symptoms without affecting hormone levels or vaginal cytology (pap smear)*

40mg qd

Liske J, et al. Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizome): a 6-month clinical study demonstrates no systemic estrogenic effect. J Womens Health Gend Based Med. 2002 Mar; 11(2): 163-74

5. Double-blind, 6 month study in hysterectomized women under 40 with at least one ovary.

·          As effective as estriol, conjugated estrogens, or hormone combinations at decreasing physical menopausal symptoms at 4, 8, 12, and 24 weeks*

4mg dry extract bid (equivalent to 2 tablets Remifemin® bid

Lehmann-Willebrock E, Riedel HH. Clinical and endocrinologic studies of the treatment of ovarian insufficiency manifestations following hysterectomy with intact adnexa. Zentralbl Gynakol. 1988; 110(10):611-8

 

6. Women aged 45 to 58 with menopausal complaints were studied in a double-blind, 12 week, placebo-controlled trial.

·          Remifemin® decreased physical symptoms of menopause by approximately 60% (Kupperman menopausal indeed)*

·          Daily hot flashes decreased by 86% in the Remifemin® group(from 4.9 to 0.7 per day)*

·          Emotional complaints were also dramatically reduced*

4mg dry extract bid (equivalent to 2 tablets Remifemin® bid

Stoll W. Phytopharmacon influences atrophic vaginal epithelium: Double Blind study – Cimicifuga vs. estrogenic substances. 1987.

 

Safety

STUDY DESIGN

BENEFITS

DOSAGE

REFERENCE

7. in vitro, MCF-7 cell culture model to determine estrogen-agopnist and antagonist activity of commercially available herbal menopause preparations containing red clover, soy black cohosh, or a combination of herbs.

·          Remifemin® had no effect on estrogen-sensitive cells in vitro.

·          Results suggest safety for women with a history of breast cancer who cannot take estrogen.

In Vitro(10^3-10^5 dilutions)

Bodinet C, Freudenstein J. Influence of marketed herbal menopause preparations on MCF-7 cell proliferation.  Menopause. 2004 May-Jun;11(3):281-9.

8. Six-week, in vivo investigation of Remifemin®’s ability to stimulate estrogen-receptor positive cells in an animal model

·          No estrogen stimulating effects were found.

·          Prolactin, follicle-stimulating hormone, and luteinizing hormone levels were unchanged.

0.714m 7.14 or 71.4mg/kg/day

Freudenstein J, et al. Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract. Cancer Res. 2002 Jun 15;62(12):3448-52.

 

 

 

9. Comprehensive review examining all published literature pertaining to pre-clinical and clinical safety of various forms of Cimicifuga racemosa, as well as FDA and World Health Organization (WHO) adverse event reporting systems, monographs, compendia, internal unpublished data from a major manufacturer, foreign literature, and historical, anecdotal report.

·          Uncontrolled reports, postmarketing surveillance, and human clinical trials of more than 2,800 patients demonstrate a low incidence of adverse events (5.4%).

·          Of the reported adverse events, 97% were minor and did not result in discontinuation of symptoms, and the only severe events were not attributed to Cimicifuga treatemtn.

·          Confirms the safety of specific Cimicifuga extracts, particularly isopropanolic preparations (Remifemin®), for use in women experiencing menopausal symptoms and as a safe alternative for women in whom estrogen therapy is contraindicated *.

Various

Low Dog T, et al. Critical evaluation of the safety of Cimicifuga racemosa in menopause symptom relief. Menopause: Journal of the North American Menopause society. 2003;10(4):299-313.

 

Relevant Reports and Guidelines

ORGANIZATION

PUBLICATION

EXCERPT OF KEY CONTENT

American Botanical Council

The ABC Clinical Guide to Herbs including a black cohosh monograph issues September 2002

“Of 10 clinical studies, including a total of 1,371 participants, nine of these studies demonstrated positive effects for menopausal symptoms.  Numerous clinical trials with varied methods and designs have been conducted on the standardized isopropanolic/ethanolic extract of black cohosh root, Remifemin®, from 1981 to the present.”

National Institute of Health

Questions and Answers About Black Cohosh and the Symptoms of Menopause issued October 2002

“Other preparations of black cohosh have been less well studied than Remifemin® …black cohosh is used primarily for hot flashes and other menopausal symptoms.  A number of studies using various designs have been conducted to determine whether black cohosh affects the menopausal symptoms… To provide more definitive evidence on the effects of black cohosh on menopausal symptoms, NCCAM is funding a 12-month, randomized placebo controlled study to determine whether treatment with black cohosh is effective in reducing the frequency and intensity of menopausal hot flashes.”

The North American Menopause Society

Alternatives to Hormone Replacement Therapy: Suggestions for the North American Menopause Siciety issued July 2002

Reseach suggests that mild hot flashes can be relieved by consuming a serving of soy foods daily or taking a supplement of black cohosh.”

 

Responding to the need for alternative menopausal symptom relief*

 

Natural, Safe alternative to HRT for menopausal symptoms*

 

  • Remifemin black cohosh was as effective as HRT for menopausal symptoms*

 

Superior Manufacturing Quality

 

  • Prepared according to Good Manufacturing Practice (GMPs) which ensure delivery of a product with the highest quality and consistency
  • Convenient dosing – one 20mg tablet twice a day (one in the MORNING, one in the EVENING)
  • 100% RemiSure black cohosh – not a combination of herbs

 

VitaNet Recommends Remifemin

 

  1. Remifemin unique standardized isopropanolic extract is the most widely studied and clinically tested natural alternative treatment for relief of menopausal symptoms.
  2. Remifemin black cohosh proven effective in reducing menopause and peri-menopause symptoms, including hot flashes, right sweats, mood swings, and irritability without estrogenic effects.
  3. Used safely by millions of patients worldwide for over 40 years.  Remifemin has been proven effective and is the most clinically studied natural intervention of menopause.
  4. Remifemin doesn’t have the side effects that are experienced with hormonal drugs prescribed for the relief of menopausal symptoms.

 

Lit source: Enzymatic therapy.

*this statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treate, cure, or prevent any disease.



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Comprehensive Prostate Formula-the Clinical Studies
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Date: October 13, 2005 04:32 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Comprehensive Prostate Formula-the Clinical Studies

Helps maintain a healthy prostate gland.

Supports normal urinary function.

Comprehensive Prostate Formula-the Clinical Studies

Saw palmetto Extract

Saw palmetto extract is one of the world's leading herbal products for prostate support. Widely-cited clinical studies conducted over the last fifteen years suggest Saw palmetto extract can produce major improvements in prostate-related urinary function. In clinical studies, Saw palmetto extract has produced measurable improvements in urinary functions and prostate size. Quality of life scores have also improved. The results with Saw palmetto extract have been duplicated in open trials and controlled, double-blind studies.11,12,13 For example, in a large open trial, 505 men took 320 mg of Saw palmetto extract daily for three months.1 The results were evaluated with various measurements such as the International Prostate Symptom Score, the quality of life score, urinary flow rates, residual urinary volume, and prostate size. After 45 days these parameters improved significantly. After 90 days of treatment nearly ninety percent of both the doctors and patients regarded Saw palmetto extract as effective as therapy for the prostate.

The changes in prostate health that accompany middle age are related to the hormone DHT, or dihydrotestosterone, a metabolite of testosterone. DHT levels rise, and DHT binds to prostate cells, accelerating growth of prostate tissue. Saw palmetto extract has been shown to inhibit 5 alpha-reductase, an enzyme that controls conversion of testosterone to DHT.14 Experimental evidence suggests Saw palmetto extract blocks the binding of DHT to prostate cells.15 The fatty acids and sterols in Saw palmetto are believed to be responsible for these actions.14,16 These include oleic acid, lauric acid, campasterol, stigmasterol, beta-sitosterol and others. Clinical studies have used extracts containing 85 to 90 percent fatty acids and sterols.

Pygeum Extract

Like Saw palmetto, Pygeum contains natural sterols and fatty acids.2 Although the mechanisms for its effect have not been clearly established, animal experiments suggest Pygeum may work by inhibiting prostate cell proliferation and reducing inflammation.17,18 In several European trials, Pygeum has successfully improved urinary function. In a large double-blind, placebo-controlled study, 263 men were given 100 mg of Pygeum extract a day for 60 days. Urination improved in 66 percent of the men taking Pygeum, compared with 31 percent on placebo, based on subjective and objective tests.19

Nettle Root Extract

Nettles are approved by the German Commission E as effective for relieving inflammation in the urinary tract.20 As far back as 1950, German investigators have observed favorable effects on the prostate with the use of Nettle root. These initial findings have been confirmed through case studies, as well as double-blind studies, published mainly in German medical journals. In a recent double blind study published in the journal Clinical Therapeutics, 134 men took a combination of Nettle root extract and Pygeum extract over a period of 56 days.3 Urination was significantly improved.

L-Alanine, Glutamic Acid and Glycine

As noted above, Drs. Feinblatt and Gant discovered that a combination of the amino acids L-alanine, glutamic acid and glycine has a positive effect on prostate-related urinary function.5 A controlled study of 45 men was conducted to follow up on these initial observations.21 The majority of subjects experienced complete or partial relief in urinary complaints such as nighttime urination and urgency.

Scientific References
1. Braeckman, J., 'The extract of Serenoa repens in the treatment of benign prostatic hyperplasia: a multicenter open study,' Current Therapeutic Research 1994: 55(7):776-85.

2. Lawrence Review of Natural Products. Pygeum. Jan 1998. Facts and Comparisons, St. Louis, MO.

3. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses Clinical Therapeutics 1993; 15(6):1011-19.

4. Wagner, H., Willer, F., Samtleben, R., Boos, G. Search for the antiprostatic principle of stinging nettle (Urtica dioica) roots Phytomedicine 1994; 1:213-224.

5. Feinblatt, H.M., Gant, J.D. Palliative treatment of benign prostatic hypertrophy. Journal of the Maine Medical Association, March 1958:99-124.

6. Giovanni, E., et. al. Intake of carotenoids and retinol in relation to risk of prostate cancer. Journal of the National Cancer Institute 1995;87(23):1767-76.

7. Wallace, A.M., Grant, J.K. Effect of zinc on androgen metabolism in the human hyperplastic prostate. Biochemical Society Transactions 1975; 3(3):540-42

8. Badmaev, V., Majeed, M., Passwater, R. Selenium: A quest for better understanding. Alternative Therapies 1996; 2(4):59-67.

9. Fouhad, M.T. Selenium and cancer, chromium and diabetes: two trace elements that have merits as dietary supplements in human nutrition. Journal of Applied Nutrition 1979:31(1&2):14-17.

10. Vescovi, P.P., et. al. Pyridoxine (Vit. B6) decreases opoids-induced hyperprolactinemia. Horm. metabol. Res. 1985; 17:46-47.

11. Tasca, A., et. al. Treatment of obstructive symptomatology caused by prostatic adenoma with an extract of Serenoa repens. Double-blind clinical study vs. placebo. Minerva Urologica e Nefrologica 1985; 37:87-91.

12. Champault, G., Bonnard, A.M., Cauquil, J., Patel, J.C. Medical treatment of prostatic adenoma. A controlled test of PA 109 vs. placebo in 110 patients. Ann. Urol. 1984; 18(6):407-410.

13. Crimi, A., Russo, A. The use of Serenoa repens extract in the treatment of functional disturbances caused by prostate hypertrophy. Med. Praxis 1983; 4:47-51.

14. NiederprŸm, H.J., Schweikert. H.U., ZŠnker, K.S. Testosterone 5 alpha-reductase inhibition by free fatty acids from Sabal serrulata fruits. Phytomedicine 1994; 1:127-133.

15. Sultan, C., et. al. Inhibition of androgen metabolism and binding of liposterolic extract of Serenoa repens B in human foreskin fibroblasts. J. Steroid Biochem. 1984; 20(1):515-519.

16. Weissner, H., et. al. Effects of the Sabal serrulata extract IDS 9 and its subfractions on 5 alpha-reductase activity in human benign prostatic hyperplasia. The Prostate 1996;28:300-06.

17. Yablonsky, F. Nicolas, V., Riffaud, J.P., Bellamy, F. Antiproliferative effect of Pygeum africanum on rat prostatic fibroblasts. J. of Urology 1997; 157:2381-87.

18. Marconi, M. et. al. Anti-inflammatory action of Pygeum extract in the rat. Farmaci. & Terapia. 1986; 3:135.

19. Barlet, A, et. al. Efficacy of Pygeum africanum extract in the treatment of micturational disorders due to benign prostatic hyperplasia. Evaluation of objective and subjective parameters. A multicenter, randomized, double-blind trial. Wien. Klin. Wocheschr. 1990; 22:667-73.

20. The Complete German Commission E Monographs. 1998, Blumenthal, M., ed., (p.216) Austin, TX: American Botanical Council.

21. Damrau, F. Benign prostatic hypertrophy: amino acid therapy for symptomatic relief. American Journal of Geriatrics 1962; 10:426-30.



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The Natural Man
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Date: June 10, 2005 03:31 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Natural Man

The Natural Man

by Chrystle Fiedler Energy Times, July 14, 2003

Men face significant health challenges as they age. "When men go through andropause in their late 40s (like women go through menopause) and testosterone drops, these hormonal changes are associated with heart attacks, high cholesterol and diabetes," says Jacob E. Teitelbaum, MD, Director of the Annapolis Research Center for Effective Chronic Fatigue and Fibromyalgia Therapy in Maryland.

And although cardiovascular disease and cancer account for about two-thirds of men's deaths, says Michael Castleman, author of Blended Medicine (Rodale), men are also plagued by chronic pain (arthritis, especially from old athletic injuries), sexual problems and mental decline.

But men, and the women who love them, need not accept decline as an inevitable sign of aging. A natural man lifestyle makeover can make a difference. "Prostate problems can be significant [for men as they age]," says Jamey Wallace, ND, clinic medical director at the Bastyr Center for Natural Health in Seattle. "As men get older there can be an enlargement of the prostate that can cause urinary problems, with increased frequency and discomfort. There's a correlation between inactivity and weight gain and perhaps prostate problems as well." Besides lack of exercise, other contributing factors to health problems include a diet loaded with pesticide residues and chemicals, a lack of fiber and an excessive amount of unhealthy fats.

The Stronger Sex?

Women, on average, live five years longer than men. "At every age, American males have poorer health and a higher risk of mortality than females," says David Williams of the University of Michigan's Institute for Social Research. The gap in life expectancy between men and women may have both genetic and lifestyle origins. More men smoke than women, and men are twice as likely to be heavy drinkers. A recent study Williams led, published in the American Journal of Public Health, confirms that men's behavior is indeed a contributing factor to longevity or lack thereof. "Men take more risks than women," says Castleman. "Men ride motorcycles, go skydiving and do 'death-defying' things. Sometimes, death wins." A macho attitude can prompt men to practice risky behavior by, say, driving without a seat belt. Men also typically engage in more dangerous occupations like construction or fire fighting.

Get Him to the Health Practitioner

Being macho may also mean men postpone visits to their health practitioners. Women are twice as likely to schedule an annual checkup.

"Men postpone admitting and getting help for problems," says Shoshana Zimmerman, ND, author of My Doctor Says I'm Fine...So Why Do I Feel So Bad? (Blue Dolphin). "They may want to prove they are tough or are preoccupied with their jobs and responsibilities." "Starting in adolescence men feel they can take care of themselves," says Dr. Wallace. Unfortunately, this means that it may take a health crisis like severe pain to prompt a man's visit to a health practitioner. "Men care less about their health, so they don't take care of themselves as well as women do," says Castleman.

Get Him to Take the Long View

"Health problems are a result of decades of poor diet and not enough exercise," says Dr. Wallace.

Dr. Teitelbaum, author of From Fatigued to Fantastic (Avery/Penguin) says, as a rule of thumb, "Things that make you feel good are generally good for you." But there is a difference between a craving, say for sugar, and what makes you feel good. The difference is how you feel an hour after you've eaten something. Sugar may make you feel fatigued; a high-protein diet may make you feel energized. "If you have low energy, that's the time to add eggs and meat. Others need to be vegans. It's really individualized. Listen to your body."

Zinc is an important nutrient for men's health, particularly for the prostate, and can be found in pumpkin seeds. "Sprinkling a small handful on salads on a daily basis or bringing a small bag to the office and nibbling on those can be a helpful adjunct," says Dr. Wallace. Don't overdo zinc supplementation because high levels can lowers HDL-the good cholesterol-levels. If you do use supplements, follow package directions.

By eating different whole foods, you get optimal daily doses of vitamin A (in the form of mixed carotenoids); flavonoids; B vitamins; vitamins C, D, E and K; and important minerals like calcium, boron, manganese and magnesium, the single most critical nutrient. "It's also the one most Americans are deficient in," says Dr. Teitelbaum. "It promotes heart health, improves mental function and mood, helps you relax and sleep better." When sleep is elusive, herbs that can help include wild lettuce, Jamaican dogwood, hops, passionflower and valerian.

For many men, an enlarged prostate is part of aging. Saw palmetto (Serenoa repens) may reduce the frequent urge to urinate that can result.

"After age 40, men's levels of testosterone decline, while levels of other hormones, notably prolactin, increase," says Castleman. "This results in an elevation of the male sex hormone dihydrotestosterone, which is responsible for the overgrowth of prostate tissue that is characteristic of benign prostate enlargement. Many studies have shown that saw palmetto shrinks enlarged prostates and relieves symptoms." It takes about six weeks to work. (Since urinary difficulties can signal several health problems, it's important to consult a trained practitioner first.)

Give Him a Multivitamin

Add a good multivitamin with essential nutrients from a natural food store, says Dr. Wallace. "You'll find vitamins there with bioavailability. You can take something but it may be in a form that you can't assimilate. You need a multivitamin that your body can actually use."

Powdered vitamin formulas can be a good choice, says Dr. Teitelbaum, since they don't have binders or fillers. "You can just put it into a glass of say orange juice or mix it into a smoothie."

In addition, omega-3 oil offers antioxidant protection and anti-inflammatory action, says Dr. Zimmerman: "Especially on the arteries, which protects against plaque buildup."

Get Him Eating Better and Exercising

To help your spouse or significant other improve his health and vitality, start by setting a good example both in nutrition and activity.

"Eat a whole-food diet yourself, include foods like vegetables, fruits and whole grains like quinoa, teff and kamut (find them at your local natural food store) full of fiber and B vitamins, instead of refined bread and pasta," says Dr. Wallace. "Choose foods you both like. Go to a natural food store and look through whole food cookbooks, find recipes that use ingredients that you know your spouse likes and try those."

"Spend your time in the produce section, have salads and fruit salads in the fridge at all times, and serve them at all meals," says Castleman.

Make gradual, healthy substitutions, steps you both can live with. For example, replace one meat lunch and dinner a week with a vegetarian alternative, says Castleman. "Make a big pot of hearty bean and vegetable soup a week, and just keep it in the fridge for an easy heat-and-eat meal." You can also broil fish instead of frying it. Use olive or canola oil when cooking.

To get your four to five servings of vegetables each day, eat a five-color salad. "You'll get a variety of nutrients so the body can select what it needs from the different vegetables," says Dr. Wallace.

"Serve more vegetables, at least two with dinner and add fruit into your man's (and your own) diet," says Dr. Zimmerman. "Eating three each of protein, vegetables and fruits per day goes a very long way to improving health." So does drinking plenty of water, eight to ten glasses a day.

Besides providing a good example by eating healthy foods, a woman can do the same thing with exercise. "If a woman wants to start walking she can invite her husband to go along. Thirty minutes of walking every day can be very helpful," says Dr. Wallace. Walking, like sex, keeps the pelvic area active and improves prostate health by stimulating blood flow. Remember, in both diet and exercise, nagging doesn't work-while setting an example and trying to be inclusive, and not demanding, often makes a big difference for better health.



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