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NATTOKINASE - A Systemic Enzyme for Healthy Circulation ...
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Date: June 04, 2005 10:25 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: NATTOKINASE - A Systemic Enzyme for Healthy Circulation ...

Nattokinase

You may not have worried about the effects of aging when you were younger. But now, you are interested in staying fit. Maintaining your cardiovascular health – for women as well as men – may be one of your greatest concerns. Every tissue in your body relies on your heart to circulate blood through approximately 60,000 miles of your blood vessels. This complex network requires a holistic health approach. Enzymes, which accelerate chemical reactions, can help with a lot more than just your digestion. Systemic enzymes are a special class of enzymes that work on every system in your body to support your overall health. Source Naturals has searched around the globe to bring you NATTOKINASE, a systemic enzyme from Japan that supports the fibrinolytic blood clearing system. Reach for NATTOKINASE to promote your cardiovascular health today.

Supports Healthy Circulation

Source Naturals introduces the science of NATTOKINASE, the natural way to support healthy circulation. A systemic enzyme derived from the fermented soy food natto, nattokinase supports your body’s mechanisms for clearing blood to maintain your cardiovascular health.

Systemic Enzymes

If you are a mature man or women, then maintaining cardiovascular health may be one of your greatest concerns about aging. Every tissue in your body relies on your heart to circulate six liters of blood through approximately 60,000 miles of your arteries, veins and capillaries. This complex network requires a holistic health approach. You might think that all enzymes are just for digestion. Actually, enzymes accelerate thousands of chemical reactions in your body. And systemic enzymes are a special enzyme class that work on every system in your body to support your complete, or systemic, health. Different systemic enzymes, such as papain, Bromelain, pancreatin and nattokinase, each work in different ways. The results can include reducing cellular irritation, promoting clear blood flow and supporting balanced immune reactions for your shortterm comfort and long-term health.

An Ancient Japanese Health Secret

The legend about the discovery of natto begins thousands of years ago with Yoshiie Minamoto, a famous Japanese warrior, who was forced to pack hot cooked soybeans in straw for traveling. When the soybeans were later unpacked, the sticky mess was considered spoiled. But when the horses, notoriously picky eaters, preferred this soy food, then people began consuming natto and discovering its health benefits.

How It Works

Healthy circulation occurs when your blood flows smoothly. It takes complex cascades of events to maintain this cardiovascular balance. Source Naturals NATTOKINASE can help. NATTOKINASE doesn’t inhibit blood clot formation. Instead, it works to support healthy circulation in three ways. First, nattokinase assists the fibrinolytic blood clearing system by breaking down cross-linked fibrin protein deposits in the blood. Second, in preliminary studies, natto extracts promote clear blood flow by reducing Euglobulin Lysis Time (ELT). Third, nattokinase supports blood clearing by breaking down Plasminogen Activator Inhibitor–1 (PAI-1), an inhibitor of an enzyme that helps keep blood flowing. Lifestyle conditions such as high stress, high glucose levels and high amounts of adipose tissue are associated with increased PAI-1 levels. Healthy circulation can do wonders to support your total health. When your circulation isn’t balanced, then your tissues aren’t getting enough nutrients and your blood isn’t clearing enough wastes away, which can increase cellular irritation and decrease overall cell health. Alternately, systemic enzymes such as nattokinase support healthy circulation so your tissues can get optimal levels of nutrients delivered and wastes removed for your better health.

Lifestyle Strategies for Maintaining Cardiovascular Health

Eat a Healthy Diet: A diet low in cholesterol, saturated fats and trans-fatty acids, and high in complex carbohydrates and fiber is important for your cardiovascular health. Good choices include fruits and vegetables, whole grains, lean red meats, fish and poultry without skin (up to 6 oz per day), lowfat or fat-free dairy products, beans and peas, and healthy fats such as olive oil in limited amounts. Avoid sugar, which has been reported to increase risk factors linked to heart disease. Some healthy cooking tips include using a rack to drain off fat when you broil, roast or bake; using wine, fruit juice or marinades to baste; broiling instead of pan-frying; using a vegetable oil spray to brown or sauté foods; and cooking with egg whites instead of yolks. Exercise Regularly: Maintaining healthy cholesterol levels is important for supporting your cardiovascular system. Exercise may increase heart healthy HDL cholesterol and lower blood triglycerides (fats), partly because of the decrease in total body fat and increase in muscle mass that usually accompanies exercise. A recent study reported that dietary changes improve cholesterol levels only when an aerobic exercise program is also included. Regular aerobic exercises—brisk walking, jogging, swimming, biking, aerobic dance, and racquet sports—are the best forms of exercise for lowering LDL and raising HDL levels. Experts recommend that people aim for a routine of 30 minute brisk walks most days of the week; an excellent goal is 20 to 25 miles a week, but in terms of raising HDL levels, more is better. Resistance (weight) training offers a complementary benefit by reducing LDL levels. Quit Smoking: Cigarette smoking lowers HDL cholesterol levels and is directly responsible for approximately 20% of all deaths from heart disease. The toxic effects of cigarette smoke damage blood vessels in the heart and legs. In fact, smoking doubles an individual’s risk of heart attack with any level of blood cholesterol. The importance of breaking this habit cannot be emphasized enough. Drink Alcohol Only in Moderation: Many studies have reported that modest consumption of alcohol increases HDL levels and protects against heart disease and possibly stroke. However, since alcohol consumption can cause other health problems, you should consult your health care professional about alcohol use. It has been suggested that antioxidants in red wine such as flavonoids and polyphenols contribute to alcohol’s protective properties. Take the Right Supplements: Many supplements can help support your heart health. Folic acid, one of the B vitamins, supports arterial health by balancing homocysteine levels. Magnesium, potassium, and calcium all help to maintain heart muscle health. Antioxidants such as betacarotene, vitamin C, vitamin E, and those found in extracts of green tea support blood vessel integrity. And omega-3 fatty acids, such as those found in flax seeds, cod liver oil, and other dietary supplements support healthy blood flow. Additionally, you can take LIFE FORCE, Source Naturals’ best selling multiple. Systemic enzymes such as nattokinase are a new class of natural compounds that can have a significant impact on your cardiovascular, joint and immune health. Source Naturals is pleased to partner with your local health food stores and participating health professionals – the only places where you can find these natural health advances – to bring you NATTOKINASE. Try this ancient Japanese secret to support your cardiovascular health today.

References
Sumi, H. et al. (1990). Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematologica. (84): 139-143. Fujita, M. et al. (1995). Transport of nattokinase across the rat intestinal tract. Biological and Pharmaceutical Bulletin 18(9): 1194-1196. Yamamoto, K. et al. (2002). Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals. Proceedings of the National Academy of Sciences. 99(2): 890-895.



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Joint Response and Ultra Joint Response
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Date: June 02, 2005 01:01 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Joint Response and Ultra Joint Response

Many people are unaware of the multiple body systems involved with joint health. Source Naturals ULTRA JOINT RESPONSE™ is a Bio-Aligned Formula™ that goes deep to bring alignment to these multiple systems. It features structural building blocks, tissue production cofactors, and ingredients that aid the body’s mechanisms for soothing relief and antioxidant defense.

Joint Support Formulations

You can use ULTRA JOINT RESPONSE alone or as the core of your healthy joints program, complementing it with additional potencies and ingredients. These include: GLUCOSAMINE CHONDROITIN WITH MSM™, MSM Cream, SAME, CM COMPLEX™ Cetyl Myristoleate, and Bromelain. For muscle discomfort and fatigue, Source Naturals also offers you FIBRO-RESPONSE™ Bio-Aligned Formula.

ULTRA JOINT RESPONSE™: BIO-ALIGNED FORMULA

ULTRA JOINT RESPONSE uses scientifically researched ingredients and nutritive co-factors for a comprehensive approach to soothing, lubricating, rebuilding and aligning connective tissue, joints, tendons and ligaments. MSM dietary sulfur, glucosamine and sea cucumber provide structural building blocks that are necessary to help maintain the integrity of joints and connective tissue. Vitamins A, B-6 and C, zinc, manganese, and copper act as co-factors or parts of enzymes that play a role in connective tissue formation and maintenance. Various soothing herbs, rich in polysaccharides and other constituents, assist the body’s natural mechanisms for soothing relief. Finally, N-acetyl cysteine, grape seed, beta carotene, vitamin C, zinc, selenium, horse chestnut, turmeric, and quercetin support the body’s natural antioxidant response, thereby helping maintain the health and integrity of joints and tissues (specifically cell membranes).

GLUCOSAMINE CHONDROITIN WITH MSM: HOT RESEARCHED INGREDIENTS

For added support, Source Naturals offers you a formula that combines higher potencies of the most popular joint nutrients: glucosamine sulfate, chondroitin sulfate and MSM. GLUCOSAMINE CHONDROITIN COMPLEX WITH MSM provides the same amounts of chondroitin and glucosamine shown in recent research to support healthy joints—along with MSM, vitamin C, and molybdenum, for a more powerful product. Together, these ingredients promote joint, tendon and ligament flexibility and easy joint movement.

FIBRO-RESPONSE: BIO-ALIGNED FORMULA Dealing with the muscle discomfort that affects millions in our society requires more than alleviating fatigue. FIBRO-RESPONSE influences specific body systems and tissues involved in joint health and muscular metabolism. Malic acid and magnesium, supplied in the same amounts used in recent research, help support muscular energy production, along with coenzyme Q10, lipoic acid and B-complex vitamins. MSM, copper, manganese, molybdenum, zinc, vitamin C, and beta carotene support healthy connective tissue, which is essential for proper joint and muscle function. Key ingredients, including N-acetyl cysteine and silymarin aid the liver in eliminating toxic waste from blood and tissues. Ingredients including lipoic acid, selenium, N-acetyl cysteine, and coenzyme Q10 support antioxidant defense, thereby helping to maintain tissue integrity. And ginkgo and GABA are among the ingredients that support clear focus and stress reduction.

LIFESTYLE TIPS FOR HEALTHY JOINTS: A STRATEGY FOR WELLNESSSM Healthy lifestyle habits should be part of your individual strategy for joint wellness. Watch Your Weight: Population-based studies, including the well-known Framingham study, have consistently shown a link between obesity and challenges to joint health. Excess weight causes pressure on joints, and can speed the rate at which cartilage wears down. Eat Healthy: To support healthy joints, increase your intake of omega-3 fatty acids from salmon, sardines, flax seeds or flax oil, avoid excess protein intake, and replace animal with plant proteins when possible. You should also eat lots of organically grown fruits and vegetables, and eliminate polyunsaturated and hydrogenated oils. Exercise Regularly: Regular physical activity helps lubricate cartilage, strengthens muscles around joints, and promotes weight control. An exercise program geared to joint health includes stretching, mild weight training, and low-impact aerobics. Rest and Relaxation: Regularly scheduled rest gives your body time to recover and rebuild, allowing you to make the most of your exercise program. It’s important to know when to slow down. Supplementation: In addition to the formulas described above, Source Naturals offers a range of products that can supplement your strategy for joint wellness. These include the pineapple enzyme Bromelain; SAMe, a natural compound formed from the amino acid methionine, which has been found to support joint comfort and mobility; and CM COMPLEX™ Cetyl Myristoleate, a fatty acid ester shown in recent research to reduce joint discomfort.



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Inflama Rest - Natural COX-2 Inhibitor for Joint Comfort
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Date: June 02, 2005 12:37 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Inflama Rest - Natural COX-2 Inhibitor for Joint Comfort

It happens. You reach for something and feel a sudden discomfort. Your joints and muscles may feel tender from overuse. Inside, your cellular systems are out of alignment, resulting in lessened mobility. Source Naturals understands how difficult joint discomfort can be to live with. We are deeply committed to developing well-researched formulas that address the root cause of joint distress. Our Bio-Aligned Formulas™ bring alignment to multiple interdependent body systems. Only this type of indepth formulation can provide the long-term relief you are looking for. Regain your comfort with Source Naturals INFLAMA-REST. Unlike many products that contain just a few ingredients to offer temporary relief, INFLAMA-REST is a Bio-Aligned Formula™, scientifically designed to address aches. INFLAMA-REST goes deep to the underlying cause of joint discomfort. These systems include: inhibition of pathways involved in joint discomfort, joint and muscle function, DNA protection and antioxidant defense.

Addressing Joint Comfort on a Deep Cellular Level

Discomfort can come from many places. From your head to your toes there are many tissues that can become uncomfortable from everyday use. Joint discomfort starts when stress, such as tissue damage, causes an imbalance of the biochemical pathways on a deep cellular level. The body has its own “innate intelligence” encompassing more than just the thoughts in the brain. It consists of ongoing and complex chemical reactions regulated by a wide variety of enzymes and chemical messengers. These reactions can sometimes get out of balance – but you can control and inhibit key body chemicals that would otherwise lead to cellular irritation. For example, certain types of prostaglandins that regulate normal physiological functions such as blood flow, are maintained at low levels in all our cells under everyday conditions. In response to stress, a message is sent to the outer membranes of certain cells to convert their fatty acids into arachidonic acid, the raw material for prostaglandins. This stress also directs cells to produce Cyclooxygenase enzyme- 2 or COX-2. This enzyme converts arachidonic acid into Prostaglandin E2, a particular type of prostaglandin specifically responsible for irritation on a cellular level. The result: joint discomfort. But that doesn’t have to happen. By supporting inhibition of the culprit COX-2, you can decrease Prostaglandin E2 production to bring your joint tissues back into a healthy and comfortable balance.

Support COX-2 Inhibition

INFLAMA-REST includes herbs that support inhibition of COX-2 in a variety of pathways. Ginger, turmeric and green tea all support direct COX-2 inhibition. But there are other places in our biochemical communication system where COX-2 production can be inhibited. Two additional factors that lead to COX-2 production are nitric oxide and the enzyme that produces it, nitric oxide synthase (iNOS). Nitric oxide is a free radical associated with cell growth and regeneration, blood vessel elasticity and COX-2 enzyme production. Resveratrol, rosemary and turmeric support iNOS inhibition, thus inhibiting your body’s over-production of nitric oxide and the COX-2 enzyme. A related irritation factor is also one of the latest scientific discoveries in cellular health - Nuclear Factor kappa-B (NF-kappa-B). NF-kappa-B works at the DNA level – at the blueprints of cells. When activated, this factor controls the genes that regulate cell growth, differentiation and regeneration. And blocking this factor is also associated with inhibition of both COX-2 and iNOS enzymes. Stinging nettle, milk thistle and Chinese Skullcap all block unhealthy NF-kappa-B activation in your body and thereby help support COX-2 inhibition.

Cytokine Inhibition

Compounds called cytokines, or interleukins, can also stimulate biochemical pathways leading to joint discomfort. Cytokines are chemical messengers produced by the immune system to regulate defensive activity when they are stimulated. For example, cytokines are released by macrophages in response to stimuli such as tissue damage. This results in rapid escalation and amplification of cell number and response. Constant stress can shift this system out of balance, resulting in tissue discomfort. Bringing these compounds back into balance can preserve your short-term comfort and longterm health. INFLAMA-REST contains curcumin from the spice turmeric. Curcumin assists the body’s inhibition of cytokine activity to support reduced cellular irritation. And Bioperine®, which is derived from black peppercorns, is added to assist curcumin assimilation.

Stress Response: Joints and Muscle Support

Inhibition of chemical messengers involved in joint discomfort is just part of a Bio-Aligned strategy for relieving discomfort. Research has shown that emotional stress, particularly long-term, can directly affect the body and set in motion mechanisms that cause physical discomfort. Ashwaganda and Chinese Skullcap (S. baicalensis) are herbs that help modulate the body’s response to stress and may help ease aches and discomfort. Boswellia, ginger, quercetin, milk thistle, feverfew, Oregon grape root and Bromelain (an enzyme found in pineapples) provide additional soothing relief to your cells and tissues. Essential nutrients are also vital to maintaining your joint comfort. The tocotrienol forms of vitamin E, along with selenium, protect cell membranes from lipid-based free radicals. Magnesium aids energy metabolism in muscles and can reduce tenderness as well as muscle spasms. Zinc is essential for normal cellular repair mechanisms such as wound healing and is important for the growth and maintenance of connective tissue. And manganese works to protect cells from oxidation and to build healthy connective tissue as well, an essential component of healthy joints and muscles.

Protecting Your DNA

To reduce cellular irritation, you need to protect the DNA in your cells. DNA is the blueprint for all of the molecules in the body. If your DNA is altered or damaged, then needed molecules may not be produced, leading to short-term and eventually long-term damage. Curcumin, from turmeric, has been shown in in-vitro studies to protect DNA against strand breakage. Quercetin has also been shown to directly protect DNA against strand breakage and base oxidation from free radicals and damaging chemicals, according to recent in-vitro research.

Providing Powerful Antioxidant Cellular Protection

Antioxidants are selfless bodyguards of your cells. They donate their own electrons to stabilize free radicals in your body. Thus, antioxidants absorb the damage that would have been done to your tissues. Some regulatory chemicals, such as Nitric oxide, are powerful free radicals and oxidants. Oxidants also activate NF-kappa-B. Tissues, lipids, proteins and DNA are extremely sensitive to oxidation. Quercetin, milk thistle, turmeric, ginger, rosemary, vitamin E and resveratrol are all antioxidants that help modulate the activity of these compounds as well as protect cells and tissues from damage. Plus, Superoxide Dismutase (SOD), one of the most important enzyme antioxidants found in your body, has been added in a new cutting-edge form. The vegetarian SOD used in INFLAMA-REST is attached to Gliadin, a wheat protein, that has demonstrated significantly better absorption than SOD alone.

Six Lifestyle Strategies for Fewer Aches


1. Try Yoga or Tai Chi. Low-impact exercise based on slow fluid movements can improve mobility and flexibility as well as greatly reduce stress.
2. Get in the pool. Exercising while in the pool reduces strain on the joints in addition to strengthening muscles.
3. Maintain a healthy weight. Excess weight adds pressure to joints and connective tissues.
4. Eat omega-3s. Omega-3 fatty acids found in salmon, flax seeds, or in supplement form support healthy joints and tissues.
5. Stay hydrated. Water is the basis of lubrication in connective tissues such as joints and skin and also supports detoxification.
6. Supplement with glucosamine, chondroitin, MSM and hyaluronic acid. These supplements can help maintain healthy connective tissues. Source Naturals is pleased to partner with your local health food store to provide INFLAMA-REST as a comprehensive Bio- Aligned Formula for relieving joint discomfort by protecting, nourishing and soothing irritated cells. Make INFLAMA-REST part of your health plan to live without joint discomfort.

  • INFLAMA-REST is a Bio-Aligned Formula™ Multi-System Support for Joint Comfort

    Inhibition of COX-2: Turmeric, Ginger, Chinese Skullcap, Green Tea, Resveratrol, Boswellia, Silymarin, White Willow Inhibition of Cytokine Turmeric, Stinging Nettle, Feverfew Inhibition of Rosemary, Green Tea, Resveratrol, Turmeric, Quercetin, Chinese Skullcap NF-kappa-B Activation Silymarin, Chinese Skullcap, Stinging Nettle, Rosemary, Resveratrol Stress Response: Ashwaganda, Magnesium, Chinese Skullcap, Oregon Grape, Feverfew, White Willow DNA Protection Turmeric, Quercetin, Rosemary Antioxidant Defense Silymarin, SOD Gliadin, Turmeric, Rosemary, Tocotrienols, Resveratrol, Ginger, Selenium, Manganese, Zinc Prostaglandin & Leukotrine Synthesis Joint & Muscle Support Inhibition of Nitric Oxide Synthesis Production



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    Heart Science - A Five-Tiered Approach to Heart Health ...
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    Date: June 02, 2005 12:07 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Heart Science - A Five-Tiered Approach to Heart Health ...

    Heart Science 30 tabs

    Your heart is crucial to every function of your body. It is the sole organ which pumps oxygen-rich blood through the entire circulatory system, feeding your cells and making life possible. Only recently are Americans realizing the importance of a proper low-fat diet, regular exercise, giving up cigarette smoking, and cutting down alcohol consumption to maintaining a healthy heart. Unfortunately, there has been a huge gap in the number of nutritional supplements which provide nutrients and herbs to support normal heart function. That’s where Source Naturals HEART SCIENCE comes in. Two years in the making, and backed by numerous scientific studies, the nutrients in HEART SCIENCE are some of the most soundly researched of all. Combining high potencies of these super-nutrients, HEART SCIENCE is the most comprehensive, cutting edge nutritional approach to proper heart care available.

    Source Naturals HEART SCIENCE— The Five Tiered Approach to Heart Health

    Your heart never rests. Even while you sleep, your heart must keep working, relying on the constant generation of energy by the body for its very survival. If this vital organ stops beating for even a short amount of time, all bodily functions cease and life ends. Source Naturals HEART SCIENCE helps support heart function on the chemical, cellular, structural, and energetic levels. This broad spectrum formula includes ingredients specifically geared for
    1) generating energy,
    2) decreasing harmful homocysteine levels,
    3) fighting oxidized cholesterol,
    4) maintaining the heart’s electrical rhythm, and
    5) protecting artery and capillary linings.

    Energy Generators for An Energetic Organ

    Every day, the human heart beats about 104,000 times, pumping over 8,000 liters of blood through the body! Because it requires so much energy to perform efficiently, the experts at Source Naturals included specialty nutrients in HEART SCIENCE such as Coenzyme Q10 and L-Carnitine — integral factors in the body’s energy production cycles — to enhance the body’s energy supply.

    There are three main interconnected energy generating cycles in our cells — the Glycolytic (sugar-burning) cycle, the Krebs’ (citric acid) cycle, and the Electron Transport Chain. Together they supply about 90 to 95% of our body’s entire energy supply, using fats, sugars, and amino acids as fuel. Coenzyme Q10 is one of the non-vitamin nutrients needed to maximally convert food into ATP (the energy producing molecule). It is the vital connecting link for three of the four main enzyme complexes in the Electron Transport Chain, the next step in energy generation after the Krebs’ cycle. Using the raw materials generated by the Krebs’ cycle, the Electron Transport Chain produces most of the body’s total energy! The heart is one of the bodily organs which contains the highest levels of CoQ10, precisely because it needs so much energy to function efficiently.

    CoQ10 is one of the most promising nutrients for the heart under investigation today. It has been postulated that as a result of its participation in energy production, CoQ10 improves heart muscle metabolism and the electrical functioning of the heart by enhancing its pumping capacity.8 Many factors such as a high fat diet, lack of exercise, and cigarette smoking can lead to suboptimal functioning of the heart, and therefore failure of the heart to maintain adequate circulation of blood. Interestingly, people whose lifestyles reflect the above factors also tend to have depleted levels of CoQ10 in the heart muscle.10

    Researchers suggest taking between 10-100 mg per day of CoQ10;18,29 HEART SCIENCE provides an impressive 60 mg of CoQ10 per 6 tablets. Similar to CoQ10, L-Carnitine is important for energy production in heart cells. It is a natural amino acid-like substance which plays a key role in transporting fatty acids, the heart’s main source of energy, to the mitochondria, the “power plants” of each cell, where they are utilized for the production of ATP. Heart and skeletal muscles are particularly vulnerable to L-Carnitine deficiency. Studies have shown that supplementation with LCarnitine improves exercise tolerance in individuals with suboptimal heart and circulatory function, and seems to lower blood lipid status and increase HDL (good) cholesterol.16, 22 Each daily dose of HEART SCIENCE contains 500 mg of this extremely important compound.

    Like CoQ10 and L-Carnitine, B Vitamins help improve the ability of the heart muscle to function optimally. Each B Vitamin, after being converted to its active coenzyme form, acts as a catalytic “spark plug” for the body’s production of energy. Vitamin B-1, for example, is converted to Cocarboxylase, which serves as a critical link between the Glycolytic and Krebs’ Cycles, and also participates in the conversion of amino acids into energy. A deficiency of B coenzymes within contracting muscle cells can lead to a weakened pumping of the heart.21

    HEART SCIENCE is formulated with high quantities of the most absorbable forms of B Vitamins providing maximum nutrition for the high energy demands of heart cells.

    Homocysteine Regulators

    B Vitamins also play a crucial role in the conversion of homocysteine, a group of potentially harmful amino acids produced by the body, to methionine, another more beneficial amino acid. While it is normal for the body to produce some homocysteine, even a small elevation in homocysteine levels can have negative implications. It is well documented that individuals who are genetically predisposed to having elevated homocysteine levels (homocysteinemics) tend to have excessive plaque accumulation in the arteries and premature damage to endothelial cells (cells lining the blood vessels and heart).26 Researchers have found that even those without this genetic abnormality, whose homocysteine levels are much lower than those of homocysteinemics, still have an increased risk for premature endothelial damage and the development of plaque in the arteries.24, 26 One study conducted among normal men and women found that those with the highest levels of homocysteine were twice as likely to have clogged arteries as were those with the lowest levels.24 Furthermore, it was found that the lower the research subjects’ blood levels of folate and B-6, the higher their homocysteine levels.24 Another study found that Folic Acid administered to normal men and women who were not even deficient in folate caused a significant reduction in plasma concentrations of homocysteine!3 In order to regulate homocysteine levels, it is critical to provide the body with sufficient amounts of B-6, B-12, and Folate, whether through the diet or through supplementation. HEART SCIENCE includes high levels of these three nutrients, providing B-6 in the regular and coenzyme form for maximum utilization.

    The Dangers of Oxidized LDL Cholesterol

    While many people have heard that high cholesterol levels may negatively affect normal heart function, few people understand exactly what cholesterol is, or how it can become harmful. Cholesterol is a white, waxy substance produced in the liver by all animals, and used for a variety of necessary activities in the body. Your liver also manufactures two main kinds of carrier molecules which transport cholesterol throughout the system: Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Cholesterol is either carried out by LDL from the liver to all tissues in the body where it is deposited, or carried back by HDLs which remove cholesterol deposits from the arteries and carry them to the liver for disposal. Because of this, LDL cholesterol is considered damaging, while HDL is considered protective. Problems occur when there is too much LDL cholesterol in the body and not enough HDL.

    When the body becomes overloaded with fat, an over-abundance of LDL particles are manufactured to process it, and they in turn become elevated in the body to a degree that the liver cannot handle. Rich in fatty acids and cholesterol, these particles are highly susceptible to free radical attack (oxidation). Once oxidized, LDL particles are no longer recognized by the body, which attacks them with immune cells. Immune cells which are bloated by oxidized lipids (called foam cells) are a key factor in the development of “fatty streaks” — the first sign of excess arterial fat accumulation. The bloated immune cells accumulate in artery lesions and create plaque in blood vessels, leading to obstruction and constriction of the vessels. Plus, these lodged foam cells continue to secrete free radicals into the bloodstream, making the problem worse.

    The development of lesions in the arteries is not an uncommon problem. Arterial (and all blood vessel) walls are composed of a chemical matrix which holds the endothelial cells in place. That endothelial layer is the first and most important line of defense in preventing large molecules, such as cholesterol and fat, from entering the vessel wall. This matrix is composed of proteins, collagen, elastin, and glycosaminoglycans (amino sugars). Arterial lesions can be caused by suboptimal collagen and elastin synthesis due to three factors: 1. Vitamin C deficiency (since Vitamin C is a key building block for collagen and elastin); 2. excessive consumption of rancid fats, or heavy usage of alcohol or cigarettes; and 3. free radical damage. Once these lesions are created, the body attempts to repair them by depositing LDL cholesterol — similar to the way one would patch a tire. If that cholesterol is not oxidized, i.e. chemically changed to a harmful, unstable molecule, then this process does not create a problem. But when arterial lesions are “patched” with foam cells, arterial walls suffer page 3 page 4 even more damage, because those foam cells release free radicals which can further damage cell membranes.

    Unfortunately, most people have a lot of oxidized cholesterol floating through the bloodstream. The typical American diet, with its low antioxidant intake and overconsumption of fried and overcooked foods, contributes to the overall levels of harmful oxidized cholesterol. In fact, the average American intake of antioxidants is low even by USRDA standards, making Americans particularly prone to having high levels of oxidized cholesterol.

    Cholesterol Fighters

    Fortunately, there are concrete steps you can take to prevent the oxidation of cholesterol, and its subsequent ill effects on health. In addition to cutting out high-cholesterol and fatty foods, supplementation can protect existing cholesterol and all tissue cells — from oxidation. Antioxidants, substances which scavenge and neutralize free radicals, protect the cardiovascular system by halting the oxidation of cholesterol, and helping to prevent plaque accumulation in the arteries and the continual secretion of free radicals by foam cells. Supplementing the diet with high amounts of Vitamin C, a key antioxidant, also encourages a more healthy “patching” of existing lesions by using collagen (made from Vitamin C) instead of cholesterol. HEART SCIENCE contains generous amounts of the following antioxidants for their protective benefits:

  • • Beta Carotene, a plant pigment, is the naturally occurring precursor to Vitamin A. When the body takes in high enough amounts of Beta Carotene, this lipid-soluble free radical scavenger concentrates in circulating lipoproteins and atherosclerotic plaques, where it performs its antioxidant functions. Beta Carotene is particularly unique and powerful as an antioxidant because it is capable of trapping a very toxic form of di-oxygen, called singlet oxygen, which can result in severe tissue damage. Beta Carotene is one of the most efficient quenchers of singlet oxygen thus far discovered. Six tablets of HEART SCIENCE provide an unprecedented 45,000 IU of Beta Carotene!
  • • Vitamin C is found in plasma, the watery component of blood, where it functions as a potent antioxidant. In addition to strengthening artery linings through collagen manufacture, Vitamin C is involved in the regeneration of Vitamin E within LDL particles. Vitamin C also plays an important role in the conversion of cholesterol into bile acids by the liver, a crucial step in reducing blood cholesterol levels. Once converted into bile acids, and then into bile salts, cholesterol can be excreted from the body, preventing build-up. Supplementation with Vitamin C may lower levels of LDL cholesterol and increase those of HDL cholesterol.25 It may also have a part in actually removing cholesterol deposits from artery walls — good news for people who are already experiencing plaque buildup.25 Each daily dose of HEART SCIENCE provides 1,500 mg of Vitamin C in its bioactive mineral ascorbate form.
  • • Vitamin E, together with Beta Carotene, protects lipids from free radical attack. It is the major antioxidant vitamin that is carried in the lipid fraction of the LDL particle, where it protects the LDL particle from damaging oxidation. Within an LDL particle, one molecule of Vitamin E has the ability to protect about 200 molecules of polyunsaturated fatty acids from free radical damage! Vitamin E also aids in protecting the heart by interfering with the abnormal clumping of blood cell fragments, called platelets, within blood vessels.4 It has been shown to inhibit the formation of thromboxanes and increase the production of prostacyclins, which together decrease abnormal platelet aggregation.11 A high potency of Vitamin E — 400 IU’s — is included in six tablets of HEART SCIENCE in the natural d-alpha succinate form, recognized by scientific researchers to be the most absorbable form!
  • • Selenium is an important mineral which has only recently gained attention. When incorporated into the enzyme Glutathione Peroxidase, it has highly powerful free radical-scavenging abilities, and has been shown to work synergistically with Vitamins A, C, and E. An essential mineral, Selenium used to be derived from eating foods grown in Selenium-rich soil. However, modern agricultural practices have depleted soil of its natural Selenium content, leaving many Americans deficient in this vital nutrient. Several epidemiological studies show that the incidence of advanced fatty deposits in blood vessels is much greater in individuals living in geographic areas of the United States and other parts of the world where the Selenium content of the soil is very low.27
  • Proanthodyn,™ an extract of grape seeds, is being called the most powerful antioxidant yet discovered. This highly potent, water-soluble bioflavonoid contains between 93-95% proanthocyanidins, the highest concentration of any nutrient available today. The protective actions of proanthocyanidins may help to prevent the development of plaque in artery walls by inhibiting the free radicals which are produced during the oxidation of cholesterol. The optimal daily amount (100 mg) of Proanthodyn is included in six tablets of HEART SCIENCE. In addition to the protective actions of antioxidants, several other nutrients can contribute to healthier cholesterol ratios.
  • • Chromium is a trace mineral which functions to aid the entrance of glucose into cells. Six tablets of HEART SCIENCE provide 300 mcg of Chromium in the form of Chromate® Chromium Polynicotinate and Chromium Picolinate — the most bioactive forms of Chromium. Not many people are familiar with the vital role Copper plays in the body. This trace mineral is found in all tissues of the body, and is particularly concentrated in the heart. Copper is part of several enzymes, and, in this capacity, is necessary for the development and maintenance of the cardiovascular system, including the heart, arteries, and other blood vessels. Because of its role in elastin production, Copper deficiency can severely damage blood vessels and heart tissue. In fact, researchers have found an inverse relationship between Copper status and increased risk for heart damage.10
  • • L-Proline and L-Lysine are two natural amino acids which show exciting promise in helping to prevent fatty deposits in blood vessels. Researchers have recently identified a particle associated with LDL called apoprotein (a) which is believed to be a main culprit in plaque development. 17 Scientific investigation has revealed that the lipoprotein (a) particle has an adhesive quality that makes the lipoprotein fat globule stick inside blood vessels. The sticky fat globules accumulate, leading to fatty deposits in blood vessels and the subsequent clogging of the arteries. L-Proline and L-Lysine tend to form a barrierlike layer around the apoprotein (a) particle, helping to push it away from the blood vessel wall, and impeding deposit.21

    The Regulating Trio

    Three nutrients — Magnesium, Potassium, and Taurine — work closely together in the body to help maintain the normal electrical rhythm of the heart, promote proper fluid balance, and prevent excessive Calcium levels from building up in the heart and artery linings.

  • • Magnesium is one of the single most important nutrients for maintaining a healthy heart. It plays an extremely vital role in maintaining the electrical and physical integrity of the heart muscle. It has been well established that Magnesium deficiency predisposes humans to serious disruptions of normal cardiac rhythm. One theory is that because Magnesium has a relaxing effect on muscle tissue, inadequate Magnesium stores may make the coronary arteries more susceptible to muscle spasm.10 Too little Magnesium can cause a Calcium/Magnesium imbalance, which can lead to the influx of too much Calcium into heart cells, and potentiate spasms in heart tissue. Another point for consideration is that because it relaxes the blood vessels, Magnesium keeps these vessels open, allowing for maximum blood flow to the heart. Magnesium also has the unique ability to stop unnecessary blood clotting by helping to reduce platelet adhesion.31 Blood clots are naturally produced by the body as a protective device to stop excessive blood flow when the body is injured. The clotting response happens when the body senses that the normally smooth blood vessel linings are rough, indicating that there is a cut. However, sometimes the body mistakes the rough surface of plaque-covered arteries as cuts, and creates unnecessary blood clots. Or, if a high fat meal has just been eaten, tiny fat globules called chylomicrons enter the bloodstream and can cause platelets to become abnormally sticky, possibly creating clots. When these clots flow through the bloodstream and reach a part of the artery which has plaque buildup, normal blood flow is blocked, and the amount of blood which reaches the heart is severely compromised. Magnesium is also crucial for the entrance of Potassium — a key mineral for many bodily functions — into the cells. Even if the body’s Potassium stores are high, without enough Magnesium, the Potassium will not be able to enter the cells and be utilized by the body. 300 mg of Magnesium (75% of the U.S.RDA) are contained in each daily dose of HEART SCIENCE. Along with Magnesium, Potassium helps to regulate normal heartbeat and blood pressure, and is necessary for the contraction and relaxation of muscle tissue. Potassium and Sodium are present in all body fluids; Potassium is found primarily within cell fluids, while Sodium is usually present in fluids surrounding cells. Together, they function to maintain the normal balance and distribution of fluids throughout the body. The body ideally should have a Potassium/Sodium balance of about 1:1; however, because the body holds onto Sodium, yet eliminates Potassium quickly, it is important that the dietary ratio of these two minerals be at least 3:1. Unfortunately, the typical American diet, with its emphasis on processed, salty (Sodiumrich) foods and lack of fresh fruits and vegetables, severely alters the body’s natural Potassium/ Sodium balance. Diets in the United States are extremely high in Sodium — sometimes containing as much as 15 times the recommended daily intake! A high Sodium/low Potassium diet interferes with the normal regulation of heartbeat and blood pressure, and has been linked with elevated blood pressure.25 Taurine is an amino acid which helps normalize electrical and mechanical activity of the heart muscle by regulating Potassium flux in and out of the heart muscle cells.

    Artery Lining Protectors

    Your arteries form an integral part of your cardiovascular system, carrying blood away from the heart to nourish other parts of the body. In a healthy heart, blood surges through the arteries with every beat of the heart. The arteries expand with each pulse to accommodate the flow of blood. When arteries become hardened and narrowed by the build-up of plaque, they can’t expand and are not able to transport blood efficiently throughout the body. This inability to open up increases blood pressure, putting a strain on the heart as well as the arteries. HEART SCIENCE includes ingredients specifically geared to protect against plaque formation within arteries and maintain the flexibility of these vital blood vessels. N-Acetyl Glucosamine (NAG) is a key amino sugar which forms the building blocks of mucopolysaccharides. Mucopolysaccharides, which are long chain sugars, are an integral component of connective tissue. They combine to form gel-like matrixes which are present throughout tissues in the body, helping to maintain the elasticity of blood vessels which must continually adapt to the changing pressures of blood flow. Each daily dose of HEART SCIENCE provides 500 mg — a substantial amount — of this vital tissue building block. There is evidence indicating that Silicon, a natural mineral, may protect against plaque formation in the arteries. Silicon is found mainly in connective tissues, where it helps bind the body’s chemical matrix. Bound Silicon is found in high amounts in arterial walls. Researchers have found that there is a steady decline in the Silicon content of the aorta and other arteries as we age. This may be due to the low fiber content of the typical American diet, since fiber is a key dietary source of Silicon.23 HEART SCIENCE includes 400 mg of Horsetail herb extract, a natural source of Silicon. Hawthorn Berry is without question the herb most widely used to encourage normal heart function. The beneficial actions of Hawthorn Berry on cardiac function have been repeatedly demonstrated in experimental studies. Supplementation with Hawthorn Berry has been shown to improve both the blood supply to the heart by dilating coronary vessels, and the metabolic processes in the heart, resulting in normal, strong contractions of the heart muscle.34 Also, Hawthorn may inhibit the angiotensen converting enzyme, which is responsible for converting angiotensen I to angiotensen II, a powerful constrictor of blood vessels.34 Bromelain, a natural enzyme derived from pineapples, has become well-known for its neuromuscular relaxing properties. Researchers have reported favorable results when using Bromelain for soothing vascular linings. Initial research also indicates that Bromelain may break down fibrin, the glue which holds platelets together to form blood clots.6

    Capillary Strengtheners

    Capillaries are the smallest, yet some of the most important, blood vessels. If you think of your cardiovascular system as a series of roads which transport blood and oxygen, then your arteries are akin to interstate highways, your arterioles are the main city boulevards, and your capillaries are local residential streets. Capillaries are so small, in fact, that single red blood cells actually have to fold up to fit through them. Because of their tiny size and the intricate nature of their network throughout the body, capillaries are responsible for actually nourishing each individual tissue cell! Along the length of the capillaries are small openings called slit pores through which oxygen, glucose, and nutrients leave the capillaries and enter the surrounding interstitial fluid. From there, they cross cell membranes and nourish the cells. Similarly, the waste products of cells enter the fluid and cross over into the capillaries, where they are then transported to the liver and kidneys for disposal. If the capillary slit pores are torn or have lesions, then blood proteins and Sodium will leak out and cause the interstitial fluid to take on a more gel-like nature. This makes the transfer of oxygen and nutrients to the cells more difficult, as well as the disposal of cell waste products, turning the fluid into a stagnant swamp instead of a flowing river. In addition to its powerful antioxidant actions, Proanthodyn also helps protect collagen and elastin, the main constituents of tissue in the capillaries, and throughout the body. It is absolutely essential for capillary walls — which are only one cell thick — to be strong and stable, so that they do not allow blood proteins to leak into the interstitial fluid. Once the interstitial fluid takes on a gel-like consistency, the surrounding cells literally become starved from lack of nutrition. The exciting news is that the proanthocyanidins contained in Proanthodyn are among the few substances yet discovered which can help strengthen capillary walls, ensuring the liquid nature of the interstitial fluid.2 Plus, proanthocyanidins help keep capillary and artery walls flexible, allowing for proper blood flow to the heart.

    Heart Smarts

    The 1990’s mark a decade of increased awareness among Americans of important health issues. Much of the discussion has revolved around protecting that precious center of life we call the heart. Simple lifestyle change is one of the most effective ways to maintain and protect the functioning of the cardiovascular system. In order to take a holistic approach to heart care, make sure you include plenty of fresh fruits and vegetables (organic, if possible) in your diet, and cut down on fatty and cholesterol-forming foods. Reduce your salt and alcohol intake to a minimum. Try to get regular, sustained aerobic exercise for at least 30 minutes three times a week. Don’t smoke – or if you do smoke, try to eat even more fresh fruits and antioxidant-rich vegetables to counter the amount of free radicals being produced in your body. Lastly, consider adding Source Naturals HEART SCIENCE to your health regimen. HEART SCIENCE, the most comprehensive formula of its kind, provides targeted protection to the entire cardiovascular system. By approaching the promotion of normal heart function on five different levels — through the inclusion of ingredients which supply energy, decrease harmful homocysteine levels, fight cholesterol build-up, help regulate electrical rhythm, and protect artery and capillary linings — HEART SCIENCE is the perfect addition to a holistic approach to heart care.

    Source Naturals HEART SCIENCE™


    The Five Tiered Approach to Heart Health
    Six tablets contain:
    Vitamins and Minerals %USRDA
    Pro-Vit A (Beta Carotene) 45,000 IU 900%
    Vit B1 (Thiamine) 50 mg 3333%
    Vit B3 (Inositol Hexanicotinate) 500 mg 2500%
    Vit B6 (Pyridoxine HCl) 25 mg 1250%
    Coenzyme B6 (Pyridoxal-5-Phosphate)
    25 mg yielding: 16.9 mg of Vit B6 845% (Total Vitamin B6 Activity) (41.9 mg) (2095%)
    Vit B12 (Cyanocobalamin) 500 mcg 8333%
    Folic Acid 800 mcg 200%
    Vit C (Magnesium Ascorbate) 1500 mg 2500%
    Vit E (d-alpha Tocopheryl Succinate) 400 IU 1333%
    Chromium (ChromeMate® †Polynicotinate-150 mcg & Chromium Picolinate††-150 mcg) 300 mcg *
    Copper (Sebacate) 750 mcg 37.5%
    Magnesium (Ascorbate, Taurinate & Oxide) 300 mg 75%
    Potassium (Citrate) 99 mg *
    Selenium (L-Selenomethionine) 200 mcg *
    Silicon (From 400 mg of Horsetail Extract) 13mg *
    * U.S. RDA not established.
    Other Ingredients and Herbs
    Coenzyme Q10 (Ubiquinone) 60 mg
    L-Carnitine (L-Tartrate) 500 mg
    Hawthorn Berry Extract 400 mg
    Proanthodyn™ (Yielding 95 mg of Proanthocyanidins from grape seed extract) 100 mg
    L-Proline 500 mg
    L-Lysine (HCl) 500 mg
    NAG™ (N-Acetyl Glucosamine) 500 mg
    Bromelain (2000 G.D.U. per gram) 1200 G.D.U.
    Taurine (Magnesium Taurinate) 500 mg
    Horsetail Extract (Yielding 31 mg of Silica) 400 mg
    Inositol (Hexanicotinate) 50 mg

    Reference:
    1. Azuma, J., Sawamura, A., & Awata, N. (1992, Jan). “Usefulness of Taurine... and its Prospective Application.” Japanese Circulation Journal, 56(1), 95-9.
    2. Blazso, G and Gabor, M. (1980). “Odema-inhibiting Effect of Procyanidin.” Acta Physiologica Academiae ScientiarumHungaricae, 56(2), 235-240.
    3. Brattstrom, E. L, Hultberg, L. B., & Hardebo, E. J. (1985, Nov.). “Folic Acid Responsive Postmenopausal Homocysteinemia.” Metabolism, (34)11, 1073-1077.
    4. Colette, C., et al., (1988). “Platelet Function in Type I Diabetes: Effects of Supplementation with Large Doses of Vitamin E.” American Journal of Clinical Nutrition, 47, 256-61.
    5. England, M. R., et al. (1992, Nov. 4). “Magnesium Administration and Dysrhythmias...A Placebo-controlled, Double-blind, Randomized Trial.” Journal of the American Medical Association, 268(17), 2395-402.
    6. Felton, G. E. (1980, Nov.). “Fibrinolytic and Antithrombotic Action of Bromelain...” Medical Hypotheses (11)6, 1123-33.
    7. Grundy, S. M. (1993, Apr.). “Oxidized LDL and Atherogenesis: Relation to Risk Factors...” Clinical Cardiology, 16 (4 Suppl.I), I3-5.
    8. Hano, O. et al. (1994, June). “Coenzyme Q10 Enhances Cardiac Functional and Metabolic Recovery and Reduces Ca2+ Overload during Postischemic Reperfusion.” American Journal of Physiology, 266(6 Pt 2), H2174-81.
    9. Heineke, et al. (1972). “Effect of Bromelain (Ananase) on Human Platelet Aggregation.” Experientia V. 23, 844-45.
    10. Hendler, S. S. (1991). The Doctors’ Vitamin and Mineral Encyclopedia. NewYork: Fireside.
    11. Jandak, et al. (1988, Dec. 15). “Reduction of Platelet Adhesiveness by Vitamin E Supplementation in Humans.” Thrombosis Research 49(4), 393-404.
    12. Jialal, I., et al. (1991, Oct. 15). “Beta-Carotene Inhibits the Oxidative Modification of Low-density Lipoprotein.” Biochimica et Biophysica Acta, 1086(1), 134-8.
    13. Jialal, I. & Fuller, C. J. (1993, Apr. 16). “Oxidized LDL and Antioxidants.” Clinical Cardiology, Vol. 16 (Suppl. I), I6-9.
    14. Jialal, I., & Grundy, S.M. (1991, Feb.). “Preservation of the Endogenous Antioxidants in Low Density Lipoprotein...” Journal of Clinical Investigation, 87(2), 597-601.
    15. Kamikawa, T., et al. (1985). “Effects of Coenzyme Q10 on Exercise Tolerance...” American Journal of Cardiology, 56, 247-251.
    16. Kosolcharoen, P., et al. (1981, Nov.). “Improved Exercise Tolerance after Administration of Carnitine.” Current Therapeutic Research, 753-764.
    17. Lawn, R. (1992, June). “Lipoprotein (a) in ...” Medicine, 12-18.
    18. Mortensen, S.A.et al. (1985). “Long-term coenzyme Q10 therapy: A major advance in the management of resistant myocardial failure.” Drugs Exp. Clin. Res., 11(8), 581-93.
    19. Nayler, W. G. (1980). “The Use of Coenzyme Q10 to Protect Ischemic Heart Muscle.” In: Yamamura Y., Folkners K., Ito Y., eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 2, Amsterdam: Elsevier/North-Holland Biochemical Press, 409-425.
    20. Press, R.I., & Geller, J., (1990, Jan.). “The Effect of Chromium Picolinate on Serum Cholesterol and Apolipoprotein Fractions in Human Subjects.” Western Journal of Medicine, 152, 41-45.
    21. Rath, M. (1993). Eradicating Heart Disease. San Francisco: Health Now.
    22. Rossi, C. S., & Silliprandi, N. (1982, Feb.). “Effect of Carnitine on Serum HDL Cholesterol: Report of Two Cases.” Johns Hopkins Medical Journal, 150(2), 51-4.
    23. Schwarz, K. (1977, Feb. 2). “Silicon, Fibre, and Atherosclerosis.” The Lancet, 454-456.
    24. Selhub, J., et al. (1995, Feb. 2). “Association Between Plasma Homocysteine Concentrations and Extracranial Carotid-artery Stenosis.” New England Journal of Medicine, 332(5), 286-291.
    25. Somer, Elizabeth. (1992). The Essential Guide to Vitamins and Minerals. New York: Health Media of America.
    26. Stampfer, M. J., et al. (1992, Aug. 19). “A Prospective Study of Plasma Homocyst(e)ine...” Journal of the American Medical Association, 268(7), 877-881.
    27. Suadicani, P., Hein, H. O., & Gyntelberg, F. (1992, Sept.). “Serum Selenium Concentration...in a Prospective Cohort Study of 3000 Males.” Atherosclerosis, 96(1), 33-42.
    28. Thomas, C. L. (Eds.). (1985). Taber’s Cyclopedic Medical Dictionary, (15th ed.). Philadelphia: F.A. Davis Company.
    29. Tsuyusaki, T. et al. “Mechanocardiography of ischemic or hypertensive heart failure,” in Yamaura Y et al., Biomed. & Clin. Aspects of Coenzyme Q.2 Amsterdam, Elsevier/North Holland Biomedical Press, 1980, 273-88.
    30. Verlangieri, A. J., & Stevens, J. W. (1979). “L-Ascorbic Acid: Effects on Aortic Glycosaminoglycan S Incorporation...” Blood Vessels, 16(4), 177-185.
    31. Werbach, M. R. (1987). Nutritional Influences on Illness: A Sourcebook of Clinical Research. New Canaan: Keats Publishing, Inc.
    32. White, R.R., et al. (1988, Jul-Aug.). “Bioavailability of 125I Bromelain after Oral Administration to Rats.” Biopharmaceutics and Drug Disposition, 9(4), 397-403.
    33. Whitney, E. N., Hamilton, Nunnelly, E. M. (1984). Understanding Nutrition, (3rd ed.). St. Paul: West Publishing Company.
    34. Willard, Terry, Ph.D. (1992). Textbook of Advanced Herbology. Calgary, Alberta, Canada: Wild Rose College of Natural Healing.
    35. Xiang, H., Heyliger, et al. (1988, Nov.). “Effect of Myo-inositol and T3 on Myocardial Lipids and Cardiac Function in Streptozocin-induced Diabetic Rats.” Diabetes, 37(11), 1542-8.



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    HEART RESPONSE - Comprehensive Support for a Healthy Heart!
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    Date: June 02, 2005 11:51 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: HEART RESPONSE - Comprehensive Support for a Healthy Heart!

    Heart Response 60ct

    Today’s modern lifestyle, filled with stress, pollution, overprocessed and fatty foods, and lack of exercise, places great strains on the cardiovascular system. Source Naturals HEART RESPONSE is a broad-range formula that supports cardiovascular health, especially heart muscle contraction, healthy circulation and the generation of cellular energy.

    HEART RESPONSE features clinical potencies of the renowned heart botanical, hawthorn, and significant amounts of the energy nutrients, coenzyme Q10 and carnitine, along with additional nutrients and herbs. Each daily use supplies 600 mg of hawthorn, the same amount used in recent research.

    Supports Heart Health

    HEART RESPONSE was formulated to include key nutrients and herbs known to support the cardiovascular system.

    Hawthorn: Hawthorn, a rich source of flavonoids and procyanidins, has been used traditionally all over the world as a strengthening circulatory and heart tonic.

    Modern research has documented that hawthorn increases coronary blood flow and strengthens the contraction of heart muscle. Hawthorn is also an antioxidant, which scavenges and neutralizes destructive free radicals. It is only when cholesterol is oxidized that it impacts the integrity of arteries.

    Coenzyme Q10: HEART RESPONSE supplies 60 mg daily of CoQ10, a key enzyme in the Electron Transport Chain, the pathway that generates 90% of the ATP “energy currency” needed by the body. Heart muscle requires huge amounts of energy to perform efficiently—it beats more than 100,000 times each day, pumping more than 1,000 gallons of blood through the body. The heart utilizes ATP as an energy source for muscular contraction. CoQ10 also is a fat-soluble antioxidant.

    L-Carnitine: Carnitine is an amino acid-derived substance that supports heart muscle metabolism. Carnitine is needed to carry long chain fatty acids into the cell mitochondria, where they undergo oxidation to generate energy. The heart utilizes fatty acids as a preferred energy source for its metabolism.

    HEART RESPONSE delivers 300 mg per day of carntine. Taurine and Magnesium: Magnesium and taurine work closely together in the body to help maintain the normal electrical rhythm of the heart. Taurine comprises more than 50% of the free amino acid pool in our hearts, and has many electrophysiological effects on cardiac muscle cells. Alterations in magnesium levels can have profound effects on the heart. Magnesium is involved in autonomic control of the heart through several mechanisms. Bromelain: Bromelain is an enzyme mixture prepared from pineapple stems. Pineapple has been used for its health benefits for more than 500 years.

    Grape Seed Extract: Grape seed is a source of procyanidins. These plant constituents are strong antioxidants that inhibit lipid peroxidation and scavenge free radicals. In vitro studies have demonstrated that procyanidins support the integrity of connective tissue. Garlic: The use of garlic for its health benefits predates written history. Garlic’s volatile oil includes sulfur-containing compounds such as allicin, which are considered to be important biological constituents.

    Selenium: Selenium is an essential trace mineral that is necessary for the activity of the important antioxidant glutathione. Antioxidants are crucial for protecting cholesterol from oxidation, which in turn helps to maintain healthy blood vessels. B-Vitamins: Preventing an undesirable buildup of homocysteine levels may help support the integrity of arteries. Vitamins B-6, B-12 and folic acid are critical to the regulation of homocysteine levels.

    You can count on Source Naturals’ expert formulators to bring you a product based on the most up-to-date nutritional research. HEART RESPONSE combines traditional botanicals and cutting-edge nutrients, scientifically formulated to deal with many aspects of cardiovascular health. It is available in bottles of 30, 60 and 90 tablets.

    References
    Heinicke, R.M. et al. 1972. Effect of Bromelain (ananase) … Experientia. 28(7):844-5. Karpati, G. et al. 1975. The syndrome of carnitine deficiency. Neurology. 25:16-24. Schmidt, U. et al. 1994. Efficacy of the Hawthorn (Cratageus) preparation L1 132 … Phytomedicine. 1:17-24. Upton, R. ed. Hawthorn Leaf with Flower – Cratageus spp. Santa Cruz: American Herbal Pharmacopoeia, 1999.



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    GlucosaMend™ Tissue/Joint Repair Complex
    TopPreviousNext

    Date: June 02, 2005 11:19 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: GlucosaMend™ Tissue/Joint Repair Complex

    GlucosaMend

    More than 40 million Americans experience joint discomfort. But exciting new research proves you can do something about it. Our health and well-being is inextricably linked to lifestyle choices: the right combination of exercise, weight training and supplementation can strengthen muscles and joint tissues to minimize stress and degradation. Targeted nutrition to the multiple body systems related to joint and connective tissue can help maintain flexibility and joint comfort. GLUCOSAMEND supports the musculoskeletal system with structural building blocks and tissue production cofactors, as well as aiding the body’s mechanisms for soothing relief and antioxidant defense.

    Bio-Aligned Formula™ GLUCOSAMEND is uniquely effective because it is a Bio-Aligned Formula. Source Naturals evaluates the underlying causes of system imbalances. Then we design formulas that provide targeted nutrition to bring your interrelated body systems back into balance.

    Musculoskeletal System—Structural Building Blocks

    Certain building blocks of joints and connective tissue can help maintain joint integrity and comfort. Glucosamine is a major constituent of glycosaminoglycans, which in turn form proteoglycans, molecules that hold and bind the water that lubricates joints, disperses stress and nourishes joint tissue. The amino acids proline and lysine are structural components of collagen and elastin, which give strength to connective tissue. GLUCOSAMEND contains glucosamine sulfate, N-acetyl glucosamine, proline and lysine.

    Musculoskeletal System—Tissue Production Cofactors

    Some micronutrients are necessary as cofactors in the production of connective tissue. For example, vitamin C and copper help form hydroxyproline and hydroxylysine, main constituents of collagen. A unique property of grape seed extract is its ability to form a bond between broken collagen fibers, helping to repair them and restore flexibility and strength to connective tissues and joints. GLUCOSAMEND provides vitamin C, zinc, manganese, copper, and grape seed extract to address these cofactors.

    Soothing Relief Mechanisms

    Some herbs and nutrients have the capacity to support the body’s natural mechanisms for increasing comfort. Boswellia, for example, is an herb with soothing properties, while vitamin B-6 helps to stabilize collagen and elastin. Additional herbs and nutrients, acting in conjunction with antioxidant protectors, support tissue comfort and health. GLUCOSAMEND contains Boswellia serrata, quercetin, copper, and vitamin B-6.

    Antioxidant Defense

    The health and integrity of joints and tissues—specifically of cell membranes— is supported by botanicals and nutrients that support the body’s natural antioxidant response. When tissues become damaged, the body mounts a repair process that ultimately generates free radicals. These free radicals can also break down healthy cells and tissues in the process, hence the need for antioxidants to neutralize and break the cycle. GLUCOSAMEND provides grape seed extract, vitamin C, zinc, selenium, copper, quercetin to neutralize free radicals.

    Lifestyle Tips for Healthy Joints: A Strategy for WellnessSM

    Healthy lifestyle habits should be part of your individual strategy for joint wellness. Source Naturals believes in a holistic approach to living. Not only can supplements bring balances to your individual body systems but certain lifestyle choices can also bio-align your health. Exercise Regularly: Regular physical activity helps lubricate cartilage, strengthens muscles around joints, and promotes weight control. An exercise program geared to joint health includes stretching, mild weight training, and low-impact aerobics. Watch Your Weight: Population-based studies, including the well-known Framingham study, have consistently shown a link between obesity and challenges to joint health. Excess weight causes pressure on joints, and can speed the rate at which cartilage wears down. Eat Healthy: To support healthy joints, increase your intake of omega-3 fatty acids from salmon, sardines, flax seeds or flax oil, avoid excess protein intake, and replace animal with plant proteins when possible. You should also eat lots of organically grown fruits and vegetables, limit saturated fat and eliminate hydrogenated oils. Rest and Relaxation: Regularly scheduled rest gives your body time to recover and rebuild, allowing you to make the most of your exercise program. It’s important to know when to slow down. Supplementation: Source Naturals offers a range of products that can supplement your strategy for joint wellness. These include the pineapple enzyme Bromelain; SAME, a natural compound formed from the amino acid methionine, which has been found to support joint comfort and mobility; and CHONDROITIN to promote water retention and elasticity in cartilage and inhibit enzymes that break down cartilage.

    Structural Building Blocks N-Acetyl Glucosamine, Glucosamine Sulfate, L-Lysine, L-Proline Tissue Production Cofactors Grape Seed, Copper, Manganese, Zinc, Vitamins A, B-6 and C, Niacinamide Soothing Relief Mechanisms Boswellia Serrata, Quercetin, Turmeric, Copper, Magnesium, Zinc, Vitamin C Antioxidant Defense Grape Seed, Quercetin, Manganese, Selenium, Zinc, Vitamins A, C and E

    References
    Bhavan’s, B. H. Selected Medicinal Plants of India (A Monograph of Identity, Safety, and Clinical Usage) Bombay: Chemexcil, 1992. Dore-Duffy, P., et al. (1990, Nov-Dec.). “Zinc profiles...” Clinical and Experimental Rheumatology 8.6: 541-46. Ellis, J. M. (1985, Winter). “Vitamin B6 deficiency and rheumatism.” Anabolism. Lakshmi, R., et al. (1991, Oct-Dec.). “Effect of riboflavin or pyridoxine deficiency on inflammatory response.” Indian Journal of Biochemistry and Biophysics 28.5-6: 481-84. Leibovitz, B., (1991). Nutrition Update 5.3: 5. Levine, M. (1986). “New concepts in the biology and biochemistry of ascorbic acid.” New England Journal of Medicine 314: 892-902. Pavelka, K, Gatterova, J., Olejarova, M, Machacek, S., Giacovelli, G., Rovati, L.C., (2002). “Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis: A 3-Year, Randomized, Placebo-Controlled, Double-Blind Study. Arch Intern Med, 2002 October 14; 162(18):2113-23. Roubenoff, R., et al. (1995, Jan.). “Abnormal vitamin B6 status...” Arthritis and Rheumatism 38.1: 105-9. Shampe, P., and R. Harvey. Lippincotts Illustrated Reviews: Biochemistry. Philadelphia: J. B. Lippincott Company, 1987. Tarp, U., et al. (1985). Scandanavian Journal of Rheumatology 14.2: 97-101. Volpi, N., (2002). “Oral bioavailability of chondroitin sulfate (Condrosulf) and its constituents in healthy male volunteers,” 2002 Oct; 10(10):768.



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    Aller Response - Deep support of multiple body systems...
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    Date: May 31, 2005 04:57 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Aller Response - Deep support of multiple body systems...

    Seasonal changes don’t need to send you running for cover. A L L E R - R E S P O N S E is a comprehensive formula designed to modulate immune system r e s p o n s e. ALLER-RESPONSE goes deep to support multiple body systems that affect inappropriate immune sensitivities. Its ingredients support histamine regulation, immune r e s p o n s e, adrenal stress r e s p o n s e, clearing, soothing and tonifying of mucous membranes, and prostaglandin metabolism.

    ALLER-RESPONSE™:

    A Bio-Aligned Formula™ Seasonal sensitivities and other inappropriate immune responses are a growing health problem in the United States. Every year more than 50 million Americans suffer from these immune symptoms*, which affect more than 20% of the population. Pollen sensitivities alone account for more than eight million doctor visits annually, at a cost of $3.4 billion! A L L E R - R E S P O N S E can help bring you relief. This Bio-Aligned Formula goes deep to support the multiple, interdependent body systems involved with immune r e s p o n s e.

    Histamine Response

    A L L E R - R E S P O N S E contains plant constituents that modify the release of histamine. Human cell culture studies with quercetin have demonstrated itsability to inhibit the release of histamine from immune cells. Ginkgo inhibits Platelet Activating Factor, which stimulates histamine secretion from platelets.

    Immune Response

    E s t a b l i s h i n g appropriate immune r e s p o n s e is critical for seasonal health. Certain essential nutrients provide support for key components of the immune system, such as mucous membrane integrity, cell-mediated immunity, and antioxidant activity. These nutrients include vitamins A, B-6, B-12 and C, and the mineral, zinc.

    Clearing, Soothing and Tonifying

    The clearing and soothing of mucous membranes in the nasal passages, throat and lungs is an important part of seasonal health. These natural compounds assist in this process: bitter orange peel, Bromelain, licorice, long pepper fruit, MSM, and stinging nettle.

    Prostaglandin Metabolism

    Prostaglandins, leukotrienes and thromboxanes are short-lived regulatory messenger molecules. They help regulate many body functions, including vasodilation and vasoconstriction, and smooth muscle contraction. Certain prostaglandins have a soothing quality and help the body maintain a state of comfort. Bromelain and quercetin have a beneficial influence on prostaglandin metabolism.

    Stress Response—Adrenal Support

    The adrenal glands produce hormones, such as cortisol, that enable our bodies to respond to stress. Supporting the adrenal glands is important for the body’s r e s p o n s e to seasonal stress. Licorice, pantothenic acid, and vitamin C support healthy stress r e s p o n s e.

    Allergy & Sinus Season:

    Healthy Lifestyle Tips

    Allergy Proof Your Home: Minimize exposure to dust mites and other indoor allergens by eliminating wall-to-wall carpets, down-filled blankets and pillows, and other dust catchers. Wash bedding regularly in hot water, and encase your mattress and pillows in airtight plastic. Dust and vacuum regularly. If you have pets, try to keep them out of your bedroom—frequent brushing and bathing can help get rid of excess pet hair. Consider using a HEPA (highefficiency particulate air) filter system, and a dehumidifier to reduce molds.

    Avoid Outdoor Allergens: You may need to limit time outdoors when pollen or mold spore counts are high. Walking through uncut fields or raking leaves can increase exposure to molds and fungi. Avoid smoke and polluted air. Keep windows and doors closed, and dry clothes indoors in a vented dryer.

    Watch Your Diet: Sometimes avoidance techniques are impractical or undesirable. Diet is easier to work with and can significantly influence immune reactions. Excess or undigested dietary proteins may worsen an overresponsive immune system—cows’ milk and wheat are frequent offenders. It may be helpful to cut down on protein, avoid dairy, and eat more fruits, vegetables, and complex carbohydrates.

    Maintain Healthy Mucous Membranes: The linings of your nasal passages, throat and lungs are your first line of defense against airborne substances. Keep them healthy by drinking 6 to 8 glasses of water daily. This thins mucus fluid and cleanses membranes. When sinuses are clogged, rinse the nasal passages with a quarter-teaspoon of salt dissolved in a cup of warm water. This washes away pollen grains and soothes irritated membranes.

    A l l e r - R e s p o n s e™ is a Bio-Aligned Formula™ Multi-System Seasonal Support

    Histamine Response Ginkgo, Quercetin Immune Support Vitamins A, B-6, B-12 & C, Zinc Clearing, Soothing and Tonifying of Bitter Orange Peel, Bromelain, Licorice, Mucous Membranes Long Pepper Fruit, MSM, Stinging Nettle Prostaglandin Metabolism Bromelain, Quercetin Stress R e s p o n s e—Adrenal Support Licorice, Pantothenic Acid, Vitamin C

    References:
    • AAII Report. 3/00, available at www.aaaai.org
    • Busse, W.W. et al. (1984). JACI, 73: 801-809.
    • Middleton, E. (1981). J Immun, 127: 546-550.
    • Pearce, F., Befus, A.D., and Bienenstock, J. (1984). JACI, 73: 819-823.



    --
    VitaNet(R)
    VitaNet ® Staff

    (http://vitanetonline.com/forums/Index.cfm?CFApp=1&Message_ID=118)

  • Buy Solaray At Discount Prices Of 43% Off And Up!

    Bromelain
      Messages 1-30 from 32 matching the search criteria.
    Health benefits of Bromelain and its mechanism of fighting inflammation Darrell Miller 4/20/13
    Natural Remedies for Arthritis Darrell Miller 2/8/12
    Secrets of Papaya Revealed Darrell Miller 2/6/12
    Can Quercetin And Bromelain Be Used As An Antihistamine? Darrell Miller 12/22/11
    Best Digestive Supplements Darrell Miller 12/8/10
    Turmeric, Curcumin, And Good Health Darrell Miller 11/11/10
    Bromelain Supplements why? Darrell Miller 11/6/10
    Fight Inflammation With Herbs from Planetary Herbals Darrell Miller 6/2/10
    Fight Inflammation With Inflama-Care - Anti-inflammatory herbal combination Darrell Miller 3/22/10
    BerryOxidants - Food-Sourced Antioxidant Protection Darrell Miller 4/12/09
    Hay Fever Darrell Miller 2/19/09
    Bromelain Enzymes Darrell Miller 5/1/08
    Fight Histamine With Quercetin Darrell Miller 2/11/08
    Are Inflammation, Immunity, And Allergic Reactions A Role For Supplements? Darrell Miller 11/10/07
    Are you allergic to what you eat? Darrell Miller 11/8/07
    Do you experience muscle pain and inflammation? Darrell Miller 4/25/07
    Degenerative joint disease (osteoarthritis) Darrell Miller 8/24/06
    Rutozym - Systemic Enzyme Supplement with Nattokinase Darrell Miller 2/22/06
    What are Papaya Enzymes good for? Darrell Miller 1/14/06
    Fight Hay Fever - Help Your Sinus... Darrell Miller 7/11/05
    Quercetin and Bromelain - for better health. Darrell Miller 7/4/05
    Digest Active - For Occasional Indigestion Darrell Miller 6/29/05
    Bromelain Sinus Ease - Nature's Life Darrell Miller 6/16/05
    NATTOKINASE - A Systemic Enzyme for Healthy Circulation ... Darrell Miller 6/4/05
    Joint Response and Ultra Joint Response Darrell Miller 6/2/05
    Inflama Rest - Natural COX-2 Inhibitor for Joint Comfort Darrell Miller 6/2/05
    Heart Science - A Five-Tiered Approach to Heart Health ... Darrell Miller 6/2/05
    HEART RESPONSE - Comprehensive Support for a Healthy Heart! Darrell Miller 6/2/05
    GlucosaMend™ Tissue/Joint Repair Complex Darrell Miller 6/2/05
    Aller Response - Deep support of multiple body systems... Darrell Miller 5/31/05



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    Health benefits of Bromelain and its mechanism of fighting inflammation
    TopPreviousNext

    Date: April 20, 2013 09:54 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Health benefits of Bromelain and its mechanism of fighting inflammation

    Bromelain is a blend of enzymes found in the juice and the stems of pineapples and is often used as a health supplement to assist in various disorders and enhance overall health. Here are the health benefits of Bromelain.

    Improved Heart health

    Bromelain functions as a blood thinner by breaking down the fibrins thus helps prevent blood clotting. It allows blood to move more freely throughout the circulatory system. Thinner blood is linked with lower possibilities of stroke, cardiac arrest and other heart problems.

    Improved Breathing conditions

    Bromelain is linked to improved breathing conditions that occur as a result of thicker mucus like asthma. It has similar effects on mucus as it has on blood thus making mucus thinner and thus does not clog the bronchial tubes.

    Improved Immunity

    It serves as an immunity booster and helps certain immunity boosting receptors within the body. As a result it fortifies the immune response by improving the response of body's front-line immune defense called the T-cells.

    Improved digestion

    If the pancreas is not very active, it may produce insufficient quantities of enzymes, making the food we eat just getting digested partially. Consuming a Bromelain supplement might help to cure any resulting digestive complaints like stomach upset, heartburn, diarrhea or indigestion. It is especially effective when used in in conjunction with other enzymes such as amylase and lipase because of its protease functions.

    Wound healing

    An external application of Bromelain might help getting rid of undesirable skin tissues in the third-degree burns. Bromelain could also reduce inflammation due to insect bites and their stings.

    Alleviates Sinusitis

    Bromelain helps decreasing congestion and the cough that comes with sinusitis. Its anti-microbial attributes may wipe out viruses and bacteria associated with sinus infections.

    Relieves varicose veins and Hemorrhoids

    Bromelain is used as a complementary medicine in treating chronic venous insufficiency, hemorrhoids and varicose veins.

    Enhanced Acid-alkaline balance

    Bromelain can help in balancing the acidity and also the alkalinity in the small intestine. The anti-bacterial effects of Bromelain helps relieving bacteria-related diarrhea connected with E. coli attacks and inflammatory bowel disease.

    Bromelain and Inflammation

    While inflammation aids mending the entire body during an injury, excessive swelling can result in health complications and speed up aging. Bromelain is beneficial in treating inflammation. The mechanism of how Bromelain fights inflammation involves the inhibition of many bio-chemical responses and reactions that induce inflammation. Treatment with Bromelain manages and regulates the activity of various bio-chemical messengers referred to as cytokines in our body. These cytokines are the chemical substances that trigger inflammation. By inhibiting the activity of cytokines, Bromelain reduces the impulses that induce an inflammatory reaction.

    Bromelain also decreases the deposition of kinins, a by-product of inflammation and also prostaglandins, the hormone-like compounds found through the entire body Thus Bromelain assists fighting the majority of inflammation occurring after having a sports injury or after surgery, or from minor sprains and tendonitis. Certain kinds of arthritis which involve inflammation also benefits from Bromelain, particularly in combination with some other typical anti-inflammatory medications.

    Do you take Bromelain daily?  If not, why not? 

    (http://vitanetonline.com/forums/Index.cfm?CFApp=1&Message_ID=2836)


    Natural Remedies for Arthritis
    TopPreviousNext

    Date: February 08, 2012 08:15 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Natural Remedies for Arthritis

    Arthritis is a kind inflammation on one or more joint. There are many kinds of arthritis. Each kind has different causes. Most common causes are injury, metabolism problem, immunity disorder, infections, hereditary factors, and much more. The symptoms are various too. But generally, it includes joint pain, swelling, redness, warmth, and stiffness. When the arthritis goes more serious, it could lead to fever, weight loss, and fatigue.

    There are many ways to cure arthritis. If the illness is quite serious, you need to go to a doctor. You can undergo a physical treatment. You can orthopedic bracing. Or, you could even need a joint replacement surgery. And if it is not so serious, you can just go to drug store to buy some analgesic, corticosteroid, acetaminophen or some anti-inflammatory medications. But, you need to remember that every drug has side effects. Analgesic could lead you to nausea and stomach upset. Corticosteroid can give make you bruise easily. It can also weaken your bones.

    The best recommendation to avoid side effects is to go naturally. Natural remedies have negligible side effects. Those have been used by our predecessors to cure many illnesses effectively. And for arthritis, there are also some ingredients that could be useful. Here are some examples:

    1. Curcumin

    Curcumin is derived from the root of tumeric plant. Tumeric is commonly used for Indian cooking and Chinese medication. Curcumin can be an effective anti-inflammatory. It can also cure stiffness and pain. For a better result, combine curcumin with Bromelain. Curcumin might be not good for a pregnant woman to consume.

    2. Boswellia

    Boswelia acid can also be an active anti-inflamatory. Commonly, it is used to cure several inflammatory problems such as asthma and some digestive ailments. Boswelia supplements sometimes are sold in capsule form.

    3. Holy Basil

    Holy basil is also known as Tulsi in India. In Ayurveda, tulsi is very sacred herb. That is why it is called as Holy Basil. In India, many houses have it planted on their yard and often use it to cure headache, influenza, and some digestive disorders. Many researches have found that holy basil also contains high anti-inflammatory and antioxidant. But it is not recommended for pregnant women.

    4. Ginger

    Ginger has an active compound called gingerol. Gingerol is very effective to cure inflammatory. You can consume ginger in many ways. You can take it as a supplement. You can easily brew the ginger root at home and drink it when it is warm. You can also just eat it. But if you want to eat it, it would be better to eat it with other foods or you might get heartburn.

    5. Glucosamine

    Glucosamine is the main element that forms cartilage and synovial fluids. It is formed by glycoaminoglycans and protein inside a human's body. Glucosamine sometimes are formed as glusosamine sulphate. It then is made as supplement and can be bought in a drug store. It is effective for many kinds of injuries and joint disorders.

    6. Hyaluronic Acid

    Hyaluronic acid is a compound can be found in synovial fluids, along with glucosamine. It is very important to keep the volume of synovial fluids and frictionless movement. When a human's body lacked of hyaluronic acid, they will experience an inflammatory conditions such as stiffness, joint pain, and arthritis.

    (http://vitanetonline.com/forums/Index.cfm?CFApp=1&Message_ID=2563)


    Secrets of Papaya Revealed
    TopPreviousNext

    Date: February 06, 2012 08:00 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Secrets of Papaya Revealed

    The benefits, an individual can derive from eating papaya should never be compared with that of consuming health pills or supplements. Papaya is not only good to eat but it also has a number of beneficial qualities.

    Benefits of Papaya

    Prevents heart attacks

    Papaya is rich in anti-oxidants. It helps to prevent cholesterol from getting oxidized and helps in preventing heart attacks. It also has ample amounts of vitamin B, folate acid and pantothenic acid, and also minerals, potassium, fiber and magnesium. Such high quantities of minerals in papaya help in the prevention of colon cancer and also in promoting good health of the heart.

    Aids digestion

    Papain, a digestive enzyme found in papaya, is very similar to Bromelain. It is helpful in the treatment of injuries due to sporty activities and also in the treatment of trauma and allergies. Papain also aids in relieving an individual from constipation problems. Papaya is a great cleansing agent for an individual’s stomach. Recent research has shown that individuals who have consumed papaya daily for three to four days have had a highly beneficial effect on their stomachs and intestines.

    Promotes healthy immune system

    Beta-carotene, which is present abundantly in papaya, helps in the making of vitamin A and vitamin C. These vitamins help in the maintaining a healthy immunity system.

    Helps prevent menstrual irregularity

    Papaya taken in its raw form helps in the reducing of menstrual irregularities in women. It eases the condition by helping in the smooth flow of the menses.

    Helps in making your skin healthy

    Papaya is highly beneficial for the skin. It helps in getting rid of acne for individuals who have acne-prone skin. When one uses papaya as a face pack, the pores of the skin get opened and thus prevent further formation of acne. Papaya helps in giving a glow to an individual’s skin. Papain, the enzyme found abundantly in papaya helps in dissolving the dead cells of the skin. Therefore it helps in giving an individual a fresh and clean look. Consuming papaya helps in allaying pre-mature aging. The anti-oxidants present in papaya help in preventing the skin from developing fine lines and wrinkles.

    Other benefits of Papaya

    Arginine, an enzyme found in papaya is extremely essential for the fertility of males. Another enzyme Carpain is considered healthy for the heart. Daily consumption of papaya helps many individuals suffering from nausea and morning sickness and hence gives them relief. Ear infections, which may trouble an individual continuously, can be allayed by the consumption of papaya. Even cold and flu can also be prevented by consuming papaya. Papaya is rich in nutrition and low on calories. Therefore, it is an excellent food for those individuals who are on a diet. Papaya is good for the hair and helps in dandruff prevention. Shampoos with papaya extracts are now readily available at medical stores. Papaya possesses anti-inflammatory and anti-cancerous qualities. Individuals suffering from pain from arthritis, edema or osteoporosis can reduce their pain by the intake of papaya.

    (http://vitanetonline.com/forums/Index.cfm?CFApp=1&Message_ID=2554)


    Can Quercetin And Bromelain Be Used As An Antihistamine?
    TopPreviousNext

    Date: December 22, 2011 07:59 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Can Quercetin And Bromelain Be Used As An Antihistamine?

    Bromelain and Quercetin

    One of the most discomforting things that anyone can experience is allergic reactions. In more severe cases it is a big concern health wise and can easily be a cause of death but in less severe cases it can be a cause of so much annoyance. Severe cases can shut your throat in a matter of minutes and keep you from breathing and the more annoying once are the ones sometimes that are caused by dust or cat hairs as a couple of examples and it will cause you to sneeze all day long or trigger a running nose or something of that sort.

    Antihistamine

    Simply put, it is a type of drug that is used to fight allergic reactions and it covers the minor to the more life threatening conditions. Each type of reaction also has a matching type of antihistamine however the bottom line is that it does one thing and that is to do what its name suggests, to counteract the chemical in our body known as histamine. This is the chemical which is released by our immune system when an allergen which is defined as a harmless external chemical, is exposed to the body. In a way an allergic reaction is our immune systems way of protecting us the problem is, in this case it is a false response. Histamine is a very powerful stimulant and has the ability to cause so much irritation within the body. The symptoms depends on the severity of the reaction, it ranges from itching, watery eyes, skin rashes, runny nose and the most life threatening one is closure of airways.

    Quercetin

    It is a pigment from plants which are found mainly in onions, berries, apples and grapes. It is considered a flavonoid. Quercetin has been used in many countries for many years to improve blood vessel health naturally and has been part of natural medicine for years now. It also has been shown in some studies to have good potency as an antioxidant and has been shown to have the ability to reduce the risk of oxidative DNA damage which is a precursor to cancer.

    Bromelain

    This refers to the plant extract which is obtained from pineapples to put it in simple terms. This substance is known to be protease enzymes as they initiate the digestion of protein which is its main function. It also has been shown on various studies that it has antiviral capabilities. However its best known medical use is for treatment of arthritis and other inflammation based illness.

    Both as antihistamines

    Quercetin, aside from the health benefits mentioned above has been shown to be able to fight against allergic reactions and Bromelain helps with its absorption so if put together it could be a potent one two punch against the common cold or flu but for severe cases against severe allergic reactions further research needs to be done to cement the idea that these substance can take the place of antihistamines.

    (http://vitanetonline.com/forums/Index.cfm?CFApp=1&Message_ID=2549)


    Best Digestive Supplements
    TopPreviousNext

    Date: December 08, 2010 05:30 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Best Digestive Supplements

    When you need to decide on a digestive enzyme supplement, it's important to know that not all of them are created equally. Some may contain more of one ingredient than the other and some might only contain one of three groups of enzymes. A leading digestive enzyme complex was studied to see what ingredients will provide your digestive system with the best possible support. Following is the ingredients of possibly the best digestive supplement you can get your hands on. digestive tract

    The first ingredient found in this complex is protease. This enzyme breaks down long protein chains at different levels of your stomach's pH level.

    Amylase is another enzyme found in this complex. It breaks down large carbs like starches into disaccharides and glucose for your body's energy levels.

    Lipase, another ingredient of the best digestive supplement, breaks down the fats you consume into fatty acids and glycerol. SOURCE NATURALS - Essential Enzymes 500 mg Vegetarian 60 caps Cerecalase, another great ingredient, is a blend of enzymes which breaks down the cell wall bonds of nutrients such as phytate and hemicelluloses.

    Glucoamylase breaks down maltose into glucose, malt diastase enhances the breakdown of starch and peptidase hydrolyzes protein molecules into amino acids.

    Bromelain

    More ingredients include Bromelain - extracted from pineapple stems, papain extracted from papaya; another enzyme which helps to digest proteins and a last ingredient, cellulase, which breaks down the cellulose and glucose found in fiber. Solaray - Bromelain 60ct 500mg You might wonder whether these enzymes are being destroyed by your stomach juices, but most of the best digestive supplements' ingredients are processed in such a manner that they can withstand the extreme conditions in your stomach. This myth has been disproven countless of times, so it's not a waste of your money to invest in the best digestive supplements.

    When you've taken the best digestive supplements, you can expect to have more energy and have better digestion and bowel movements. It is normal for some people to experience detoxification in the beginning stages of taking these supplements. This might feel uncomfortable but it is a good sign that your body is responding positively to the enzymes. Upping your enzyme intake and drinking a lot of water can help you through the beginning process.

    When looking for the best digestive supplement, you should look at the enzyme activity rather than the ingredients. The most important thing is to look out for supplements that are acid stable and able to be active in a broad range of pH levels. Steer clear of any ingredients you might be allergic to, like papain or Bromelain. Look for what experts call a broad range digestive supplement. The more enzymes it contains, the wider the range of nutrients it will make your body able to digest. When in doubt, speak to your doctor or pharmacist first. If you have specific digestive problems you should have that looked into before trying such a common remedy.

    (http://vitanetonline.com/forums/Index.cfm?CFApp=1&Message_ID=2202)


    Turmeric, Curcumin, And Good Health
    TopPreviousNext

    Date: November 11, 2010 03:48 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Turmeric, Curcumin, And Good Health

    turmeric Leaves

    Turmeric and its history

    Turmeric is not just an ancient Asian spice but also an effective traditional alternative medicine used worldwide. Turmeric is a spice that originates in India and has been long used in both Ayurvedic and Chinese traditional medicine. This spice comes from the herb Curcuma longa L. which is a member of the Curcuma botanical group, a part of the ginger family of herbs called Zingiberaceae. The root and rhizome (underground stem) of this plant is crushed and powdered into ground Turmeric. Ground Turmeric is used worldwide as a seasoning and the main ingredient in curry powders. Ground Turmeric is also the source of Curcumin, an extracted potent substance also used as alternative medicine nowadays.

    Turmeric, because of its Curcumin content, has many health benefits to humans. Firstly, Turmeric has an anti-inflammatory property. Its active ingredient, Curcumin, has been proven to help reduce inflammation. Decade to decade, Turmeric has been used as an anti-inflammatory agent to treat inflammations of the skin and muscles. Experiments done by researchers also revealed that this herb has been effective in decreasing post-surgical inflammation. This important health benefit of Turmeric is considered to be a result of the herb’s ability to slow down, if not to totally stop, Eicosanoid Biosynthesis, one of the processes the immune system undergoes during an inflammatory response.

    Secondly, as a result of its anti-inflammatory characteristic, Turmeric also has an anti-arthritic property. It is widely used as an alternative medicine for rheumatoid arthritis and other autoimmune disorders. In addition, this herb also has a natural painkiller effect. Studies show that it has similar actions to the commonly used medications such as COX-2 inhibitor and Nonsteroidal Anti-inflammatory Drugs.turmeric root

    Thirdly, several studies have shown that Turmeric is also helpful in lowering the level of bad cholesterol in the blood known as the Low Density Lipoprotein or LDL and in increasing the body’s good cholesterol, High Density Lipoprotein or HDL. An increased level of LDL promotes cholesterol plaque deposits to the walls of blood vessels, most commonly in the arteries of heart. These plaques narrow the arterial diameter hence resulting to high blood pressure and even circulation blockage. An arterial block may cause poor circulation and oxygenation to heart muscles leading to cardiac injury then infarction. This is oftentimes the cause of heart attacks. It has also been discovered that Turmeric can promote excretion of dietary fats. Thus, controlling the intestinal uptake of fats, especially cholesterol.

    Turmeric - Powerful Antioxidant

    turmeric powder Lastly, Turmeric is also widely used because of its anti-oxidant property. Studies demonstrate that Turmeric is effective in eliminating free radicals in the body. These free radicals are harmful. It may cause cell mutations which can lead to tumor formation and, worse, cancer.

    This herbal plant can be prepared in the household by pounding and pressing its roots to be able to extract the juice out. It is then mixed with water and may be used topically or by nasal inhalation. The root can also be lightly cooked and eaten. Turmeric is also helpful in earaches and to clear clogged sinuses thus easing breathing. This herb can also be purchased in bulk powder or standardized forms to ensure its beneficial properties are intact.
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    Bromelain Supplements why?
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    Date: November 06, 2010 10:32 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Bromelain Supplements why?

    pineapple BromelainBromelain enzyme may not be as familiar as other digestive supplements to most people but this helpful catalyst offers a wide range of benefits not only to the digestive system but also to other systems of the body.

    Bromelain Enzyme Supplement

    Bromelain enzyme is a proteolytic digestive catalyst that contains sulfur. From the word “proteolytic”, this substance aids in the digestion of proteins especially when taken with meals. On the other hand, when taken without meals, it is deemed to act as an anti-inflammatory supplement. Ananas comosus or the pineapple plant is the best source of this beneficial enzyme. However, fresh pineapple extract does not contain doses high enough to have a medicinal effect. Hence, a preparation to meet the body’s demand is produced. Bromelain supplements now come in the form of tablets and topical creams. They are now widely available and affordable to counterweigh the several uses it offers.

    In the Digestive System, Bromelain enzyme does not only help in digesting proteins but may also relieve gastric upset and heartburn especially when used together with other digestive enzymes like amylase, a catalyst responsbile for carbohydrate digestion, and lipase which is for the digestion of fats. Diarrhea conditions associated with deficiency in the proteolytic enzymes can also be alleviated with the use of this supplement.

    In the Immune System, Bromelain has been widely considered as an effective relief for pain and swelling caused by both injury and certain infections. Studies frequently show the Bromelain’s ability in facilitating the body to restore health more quickly. The mechanism is said to be a reduction of fibrin and leukotriene accumulation, thus regulating the inflammation process. Researchers have demonstrated evidences that a daily intake of 1,200 to 1,800 mg of Bromelain may help alleviate painful inflammation just like in rheumatoid arthritis.

    In the Cardiovascular System, Bromelain supplement is theorized to play a role in the prevention of heart disease caused by atherosclerosis or thickening of the arterial wall due to plaque deposits. It slows down the clumping of platelets thus preventing a possible heart attack. digestive process Bromelain

    Bromelain May Also Relieve Pain

    Lastly, Bromelain may also relieve pain associated premenstrual syndrome and menstraul cramps. Studies reveal that they act as prostaglandin inhibitors. However, Bromelain can also increase the bleeding during menstruation.

    Bromelain supplement has no Recommended Dietary Allowance but doses of up to 1 gram taken 3 times a day showed no toxic effects. Experts also advise to take Bromelain on an empty stomach supplemented with magnesium to increase the Bromelain’s effects.

    Just like any other drug or food supplement, Bromelain also has side effects, nonlife-threatening to be exact. It may have drug interactions such as increasing the absorption of some medications like antibiotics, chemotherapeutic drugs and specific antihypertensive agents. In addition, it may also bolster the effects of blood thinners such as warfarin (Coumadin), anti-inflammatory drugs and antiplatelet agents such as clopidogrel (Plavix). Since Bromelain supplement can cause certain drug interactions, it is important to take this enzyme cautiously or under the supervision of a qualified health care provider.

    To find quality Bromelain supplements, look to your local or internet vitamin store.
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    Fight Inflammation With Herbs from Planetary Herbals
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    Date: June 02, 2010 04:39 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Fight Inflammation With Herbs from Planetary Herbals

    Inflama-Care 60 tabs from PLANETARY HERBALSOur modern lives have untold benefits, as well as challenges. Our dependence on man-made toxic chemicals, junk food, nutrient imbalanced diets, and our stressful, sedentary lifestyles can alter our biochemical metabolism and affect our health.

    These lifestyles and environmental change can challenge immune health, so that the various components of the immune system are not able to carry out their protective functions. Or our immune systems can go into overdrive, often leading to a state called metabolic inflammation.

    A Powerful Herbal Blend

    Inflamma-Care is a potent, herbal response to the metabolic inflammation that can result from inappropriate immune response. The main component of inflama-care is the rhizome of the curcuma spicies, long used as a spice in India. Known worldwide as turmeric (curcuma longa), it acts as an anti-inflammatory by inhibiting the activities of cytokines – inflammation messengers.

    This world-renowned spice is supported by boswellia, which inhibits pro-inflammatory enzymes, and ginger an antioxidant that inhibits prostaglandin and leukotriene biosynthesis. Other herbs in the formula that inhibit inflammatory action include willow bark, Chinese skullcap, corydalis, holy basil, and hops.

    Inflama-care also contains systemic enzymes to clear and protect the arteries and circulatory system. Systemic enzymes like Bromelain and papain cleanse the bloodstream and enable the blood to flow smoothly. A free-flowing bloodstream helps the body by circulating important nutrients to the cells while clearing the body of wastes.

    Immune Activating Mushroom

    Planetary Herbals also offers you new Full Spectrum Chaga in 1000mg tablets and a 1:4 liquid extract. Preliminary studies suggest that chaga triggers immune responses and protects the cells with antioxidant activity.

    Chaga is a mushroom that is found attached to trees like birch, alder, beach, and other hardwoods, throughout the northern Chaga Full Spectrum 60 tabs from PLANETARY HERBALSlatitudes. A polyphore, the mushroom looks somewhat like coal – a brownish black mass often seen in tree trunks. In China, Siberia, Finland, Japan, Poland and North America, ancient and native peoples have long known the benefits of chaga. In an acient treaties, the Chinese monk shen nog declared in 100 BC that chaga is “a precious gift of nature.”

    In modern research, chaga has been shown to have 215 phytonutrients, including 29 beta-glucans. Chaga also absorbs a nutrient from the outer birch tree bark: betulin, a natural anti-inflammatory. Among the components in chaga are triterpenes, sterols, beta-glucans, flavonoids, melanins, polyphenols, saponins, lignin, amino acids, vitamins, minerals, and fiber. This fascinating combination of nutrients is being studied worldwide.

    The PhytoDynamic Difference

    Both inflama-care and full spectrum chaga are formulated with a profound understanding of the ways in which plant compounds interact with human physiology. Planetary Herbals phytodynamic principles draw on herbal tradition, scientific research, and a level of clinical expertise unmatched in the natural products industry. The result: herbal products unsurpassed for quality and consumer satisfaction.

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    Fight Inflammation With Inflama-Care - Anti-inflammatory herbal combination
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    Date: March 22, 2010 09:07 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Fight Inflammation With Inflama-Care - Anti-inflammatory herbal combination

    turmeric root sample for articleTurmeric / Boswellia Complex

    Our modern lives have untold benefits, as well as great challenges. Our dependence on man-made toxic chemicals, junk food, nutrient-imbalanced diets, and our stressful, sedentary lifestyles can alter our biochemical metabolism and affect our health. These unhealthy lifestyles and environmental changes have set our immune system on overdrive, a state call metabolic inflammation. Planetary Herbals Inflama-Care is a potent, herbal response to these modern challenges.

    The Inflammation Cycle

    As toxins and stress begin to alter our body chemistry and change the function of vital tissues, our body reacts with metabolic inflammation just as if it were being attacked. This reaction may result in a perpetual cycle of chemical imbalances and suboptimal health. Yet metabolic inflammation is often below the threshold of perception, not noticed or felt for years after its starts. It is only much later that the altered biochemistry and the system imbalances that it generates are noticed.

    A Powerful Herbal Blend boswellia sample for article Inflama-Care helps support the body’s natural response to metabolic inflammation. The main component of the formula is the rhizome of the curcuma species, long used as a spice in India. Known worldwide as turmeric (Curcuma longa), it acts as an anti-inflammatory by inhibiting the activities of cytokines—inflammation messengers. This world-renowned spice is supported by boswellia, which inhibits proinflammatory enzymes, and ginger, an antioxidant that inhibits prostaglandin and leukotriene biosynthesis. Other herbs in the formula that inhibit inflammatory action include willow bark, Chinese skull cap, corydalis, holy basil, and hops.

    The PhytoDynamic Difference

    Planetary Herbals presents inflama-Care to help maintain the body’s biochemical balance and integrity. Inflama-care was formulated with a profound understanding of the ways in which plant compounds interact with human physiology. Planetary Herbals phytodynamic principles draw on herbal tradition, scientific research, and a level of clinical expertise unmatched in the natural products industry. Thie result: herbal products unsurpassed for quality and consumer satisfaction.
    Inflama-Care 60 tabs from PLANETARY HERBALS

    Amount %DV
    Calories 5
    Calcium (naturally occurring and dibasic calcium phosphate) 57 mg 6%
    Sodium (naturally occurring) 5 mg <1%
    Turmeric Rhizome Extract (95% curcumin) 900 mg
    Boswellia serrata Gum Resin Extract (85% boswellic acid) 400 mg
    Ginger Root Extract (5% gingerol) 250 mg
    Willow Bark Extract (15% salicin) 100 mg
    Chinese Skullcap Root Ext. (30% flavones) 100 mg
    Bromelain 100 mg
    Papain 100 mg
    Hops Flower Extract (Perluxan™) yielding 30 mg Humulex™ alpha-acids 50 mg
    Corydalis yanhusuo Tuber 50 mg
    Holy Basil Leaf Extract (2% ursolic acid) 50 mg
    Quercetin 50 mg
    Rosemary Leaf Extract (20% diterpenes) 50 mg
    trans-Resveratrols (from Polygonum cuspidatum root extract) 25 mg
    Masson Pine Bark Ext. (95% procyanidolic value) 25 mg
    Grape Seed Extract (95% procyanidins) 25 mg
    EGCG (epigallocatechin gallate) (from decaffeinated green tea leaf extract) 25 mg
    Lecithin 25 mg
    Black Pepper Fruit Extract (Bioperine®) 5 mg

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    BerryOxidants - Food-Sourced Antioxidant Protection
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    Date: April 12, 2009 11:07 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: BerryOxidants - Food-Sourced Antioxidant Protection

    BerryOxidants - Food-Sourced Antioxidant Protection

    • A power-packed antioxidant complex featuring standardized extracts from fruits, especially berries, as well as herbs and spices.
    • This synergistic formula combines more than 30 plant-derived free radical fighters with a full 500 mg per tablet of the antioxidant vitamin C.
    • Some scientific evidence suggests that consumption of antioxidant vitamins may reduce the risk of certain forms of cancer. However, the FDA has determined that this evidence is limited and not conclusive.
    • Addresses six of the 12 SystemiCare™ body systems identified by Source Naturals as necessary for your optimal health: Liver/Detox (which may support longevity), Antioxidant Defense, Immunity, Circulation, Inflammation Response, and Structure/Connective Tissue.

    2 tablets contain:

    Vitamin C (as ascorbic acid) 1,000 mg

    Grape Seed Extract (Proanthodyn™) 150 mg

    Green Tea Leaf Ext (95% polyphenols, 150 mg 35% ECGC)

    Turmeric Rhizome Ext (95% curcumin) 150 mg

    Polygonum cuspidatum Root Ex 100 mg (8% total resveratrols)

    Bromelain 100 mg

    Quercetin 100 mg

    Ginkgo Leaf Extract (50:1) 60 mg

    24% Flavoneglycosides

    Silymarin (from milk thistle seed ext) 60 mg

    Hawthorn Berry Extract (4:1) 50 mg

    Rosemary Leaf Extract (5:1) 50 mg

    Citrus Bioflavonoids 50 mg

    Lecithin 50 mg

    Grape Skin Extract (20% polyphenols) 50 mg

    Astragalus Root Extract (10:1) 50 mg

    Cabbage Floret & Stem 50 mg

    Cranberry Fruit Ext (90% solids) 50 mg

    Sweet Cherry Fruit Ext (10:1) 50 mg

    Holy Basil Leaf Ext (2% ursolic acid) 50 mg

    Olive Leaf Ext (15% oleuropein) 40 mg

    Rutin 40 mg

    Lycium Fruit Extract (4:1) 40 mg

    Strawberry Fruit 40 mg

    Açai Fruit Juice Powder 40 mg

    Organic Amla Fruit 40 mg

    Pomegranate Seed Ext (40% elagitannins) 20 mg

    European Elder Berry Ext (5% flavones) 20 mg

    Mangosteen Fruit Rind Extract 20 mg (standardized to 95% flavonoids & 40% mangostins)

    Raspberry Leaf Ext (40% elagitannins) 10 mg

    White Mulberry Fruit Ext (10:1) 10 mg

    Blueberry Leaf Ext (20% chlorogenic acid) 10 mg

    Bilberry Fruit Ext (25% anthocyanidins) 5 mg

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    Hay Fever
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    Date: February 19, 2009 05:14 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Hay Fever

    Hay fever, which is an allergy to proteins in the pollen of trees, grasses, some plants, or mold, affects the mucous membranes of the nose, eyes, and air passages. Symptoms of hay fever include itchy, red eyes; watery discharge from the nose and eyes; sneezing; fatigue; and nervous irritability. Many of the symptoms of hay fever can be confused with those symptoms of the common cold. However, allergies cause a distinctive clear, thin nasal discharge, whereas secretions that come from colds are usually thick and yellow-greenish as the illness progresses. Colds are also associated with mild fever and are usually gone within a week. On the other hand, allergy sufferers often feel wiped out for many weeks.

    At least 50 million Americans suffer from seasonal sneezes, runny nose, and itchy eyes that come with hay fever. There happen to be three seasons of hay fever which are distinguished by the different pollen present at these different times of the year. Tree pollen appears first, usually between February and May, depending on the climate. When trees, weeds, grass pollens, and people are out at the same time, the biggest problems arise. This usually occurs later in spring and in summer. The fall is the season for ragweed pollen. Depending on which pollen or pollens an individual is allergic to, hay fever may be present at any or all of these times.

    In more detail, the following is a summary of the types of plants according to the times of year they are most likely to cause problems. Alder, hazelnut, and elm trees cause the most problems in February through May, while birch, maple, and oak trees are problematic in March through June. Beech and spruce trees bring about issues in April through June, while horse chestnut trees are responsible for causing problems in April through August. In April through September, Asters, pine trees, plantain, sorrel, stinging nettle, and various grasses are responsible for bringing about allergies. Buttercups are problematic in May through July and Goosefoot is an issue in June through September. In July through September, mugwort seems to pose a problem.

    Those people who suffer from hay fever also often suffer from other atopic disorders like asthma and dermatitis. Those people who suffer from hay fever symptoms throughout the year are said to have perennial rhinitis, which can be caused by animal hair, dust, feathers, fungus spores, molds, and/or some other environmental agent. It should be noted that a susceptibility to hay fever tends to be an inherited condition. Those people who are most prone to allergies are often aware of the time of year and conditions under which they are most sensitive. A RAST test can easily be done and provide reliable results for a definitive diagnosis.

    The following nutrients are beneficial for hay fever: Bromelain, coenzyme Q10, Quercetin, raw thymus, vitamin A, vitamin B complex, vitamin C with bioflavonoids, proteolytic enzymes, zinc, calcium, magnesium, garlic, kelp, manganese, Pycnogenol, SOD, and vitamin E. Additionally, the following herbs have been noted to be helpful: alfalfa, chlorophyll, vitamin K, eucalyptus oil, eyebright, lady’s mantle, goldenseal extract, horehound, mullein leaf, stinging nettle, wild cherry bark, turmeric, nettle leaf, and noni juice.

    In conclusion, discovering your allergic substance is the first step to recovery. When you can narrow down what is the cause then you can combat the problem with vitamins, herbs, and dietary changes. Your local or internet health food store has a large selection of herbal and homeopathic remedies for hay fever symptoms.



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    Bromelain Enzymes
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    Date: May 01, 2008 02:45 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Bromelain Enzymes

    Bromelain consists of two enzymes that digest proteins, otherwise known as proteases or proteolytic enzymes. These enzymes are obtained from different parts of the plant, one from the stem and the other from the fruit. It also includes protease inhibitors, acid phosphatase, peroxidase and calcium.

    First used as a supplement in 1959, Bromelain is particularly popular in Germany, where a lot of the recent research has been carried out. Because the stem enzyme is in the greatest amount, eating pineapple will not give a great deal of Bromelain, and you will have to take the supplement which is extracted from the stem in order to get the greatest benefits.

    Bromelain has several therapeutic effects on the body, and is a good aid to digestion. The enzyme can boost the digestive processes and so reduce the incidence of problems such as heartburn, acid reflux and any other condition caused by the incomplete digestion of foods. It does this by breaking down proteins so they are more easily digested.

    In fact its potency is sometimes measured in GDUs (Gelatin Digesting Units), gelatin being a common protein that is easily used for the measurement of Bromelain activity. It is also measured in MCU (Milk Clotting Units), since Bromelain can also be used to clot milk, and a standardized dose should contain 2 MCU per milligram. The dosage to use depends a great deal on the condition being treated, but a good general average for digestive problems is 500 mg three times daily.

    Bromelain works best at an optimum pH of 4.5 – 5.5 and can therefore help to balance the pH in its environment. It is extremely important to the immune system that the pH of the body is balanced and controlled to within certain limits, and Bromelain can help to achieve that. In helping to reduce the excessive acidity caused by poor digestion, a balanced pH of the stomach is also maintained, helping to reduce the feeling of nausea, common with some digestive defects. The overall result of Bromelain supplement is to help to maintain a better digestive system and ease the discomfort of many people for whom a meal is frequently not the pleasure it should be.

    Bromelain is also an anti-inflammatory, and used for temporary relief of the inflammation caused by surgical procedures, arthritis and various injuries and forms of disease It is commonly used for the treatment of sports injuries and also immediately after surgery to reduce the risk of inflammation. It appears to have an inhibiting effect of the production of pro-inflammatory metabolites in the body, although the mechanism by which it works is not yet fully understood.

    In fact many of the therapeutic benefits of Bromelain have been show to be only partially due to its proteolytic activity, and it is now believed that there are also as yet unidentified non-protein factors present in Bromelain that contribute to these forms of health benefit. The biochemistry of Bromelain has yet to be fully characterized.

    Notwithstanding that, the substance has been recommended for the treatment of a wide range of connected conditions, such as gout, arthritis, hemorrhoids, ulcerative colitis, autoimmune disorders, hay fever and sinusitis. It is particularly useful where there is pain, where tissues have become swollen and when tissue repair is needed. It appears to inhibit pain-inducing prostaglandins and is also believed in some way to induce the biochemical production of other prostaglandins that have an anti-inflammatory effect.

    All of this knowledge has come as a result of studies carried out on the biochemical activity of Bromelain, but have not yet been proved and is indicative of the lack of biochemical knowledge on this substance and the chemicals it contains. What have been demonstrated, however, are its effects on platelets and blood clots in arteries.

    It appears to do this by the inhibition of the formation of high levels of fibrinogen from which clots are made, and also inhibits the aggregation of blood platelets and their ability to stick to the endothelial cells of blood vessels, particularly the arteries. The fibrin that is produced from fibrinogen not only promotes blood clotting but is also associated wit the retention of fluid. It is a protein, and the proteolytic effect of Bromelain also breaks this down.

    Bromelain therefore works in a number ways to reduce fluid retention, prevent blood clotting and inhibit the aggregation of blood platelets on artery walls. The measurable effect of this is the thinning of the blood that such activity promotes. It is logical that if fibrin contributes to the viscosity of blood, then its destruction will result in thinner blood, and hence lower blood pressure.

    It is also used in the treatment of burns, where it helps to remove the dead skin that can delay recovery after third degree burns. It also appears to promote the absorption of many antibiotics, which again helps in recovery.

    Bromelain is relatively safe to use with few side effects, although, curiously, among the side effects are some conditions it is also used to treat. Among these are nausea and allergic reactions, along with diarrhea and excessive menstrual flow. One of its successes has been in the control of menstrual pain.

    Bromelain has been proposed for cancer therapy, its potential use being recommended due to its effect of the adhesion of cells, its regulation of the immune function and its effect on the immunosuppressive cytokine TGF-beta that is involved in several types of cancer and their metastasis (spread to other parts of the body). However, a lot more work is needed on this for definite conclusions to be drawn.

    On a more practical note, the effect of Bromelain on proteins is put to use as a steak tenderizer. If the product is sprinkled in powdered form onto meat, and then forked into the tissue, the enzymes will break down the protein of the meat and make it tender when cooked. However, don’t overdo it or you will end up eating a meaty mush more akin to a soft meatloaf than a good steak!

    All in all, Bromelain is a useful supplement for many medical conditions, and does to food in your stomach what it does to steak on the plate. It is generally used in supplement form because the active enzyme is not in a high enough concentration in the fruit itself, but in the stem from which it is extracted after the fruit has been harvested. It is also easier to standardize a supplement than a fruit.

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    Fight Histamine With Quercetin
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    Date: February 11, 2008 03:48 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Fight Histamine With Quercetin

    Quercetin is one of the more powerful of the body’s antioxidants, and it can also be used to reduce the rate of histamine release by the body normally initiated by contact with an allergenic substance (for which your immune system has designed an antigen). We shall examine the biochemical mechanism which this is achieved, but first let’s have a closer look at quercetin and what it actually is.

    Quercetin is what is known as a phytochemical, which is simply the scientific name for a chemical that is naturally produced by plants. Other phytochemicals include vitamin C and omega 3 fatty acids, so the term is very broad ranging for any substance that is produced by plants. It is commonly known as a flavanol, one of a family of compounds known as flavonoids that give color to plants.

    It is a very active flavonoid, with very powerful antioxidant properties, in addition to acting as an anti-histamine and anti-inflammatory. Histamine is an amine released as part of the body’s immune response to allergenics, and quercetin inhibits its manufacture and release. This amine is an irritant and can itself cause inflammation and the other symptoms associated with allergies such as runny and itchy eyes, a stuffy nose, sneezing and itchy spots. Quercetin can be used to alleviate these symptoms by blocking the manufacture in the body of the histamine that causes them.

    It demonstrates other anti-inflammatory properties such as alleviating the symptoms of arthritis, and also helps to destroy free radicals in the body through its strong antioxidant properties, but before we discuss how it does this we shall have a closer look at the mechanisms used in its effect in inhibiting histamine.

    Calmodulin is a protein that is used to transport calcium ions, Ca++, across the membranes of certain cells in the body, and by doing so it helps to mediate a number of biochemical processes within the body, among them the immune response and inflammation. It should not be thought these are always unwelcome responses: on the contrary, they are the body’s way of reacting to foreign bodies and preventing more serious conditions from developing.

    However, there are instances where the body can become sensitized to certain substances and overreact to their presence leading to conditions such as hay fever or, considerably more serious, asthma. These are just two of the undesirable manifestations of the human immune system that we would be better without. What quercetin does is to prevent calmodulin from properly binding to certain enzymic proteins and so suppress the effect of these proteins. Among these are the enzymes that control the secretion of histamine from mast cells.

    Mast cells are found mainly in areas prone to injury and at the interface between internal tissues and outside world, such as the nose, mouth, lungs, eyes, blood vessels and feet. They contain granules rich in histamine that degranulate and released the histamine when the immune system detects foreign bodies such as pollen grains and dust mites, especially when the body has created antigens against them.

    Quercetin suppresses the release of histamine from the granules in the mast cells by preventing the degranulation. The release of the histamine is not completely halted, but its effects are reduced and quercetin is used in the treatment of asthma where it is believed to help reduce the symptoms by reducing histamine-induced swelling in the airways.

    A similar application of this flavonoid is in reducing the inflammatory response to arthritis, the main cause of the swelling of this painful condition. Your skin can also be affected by inflammation that is partially controllable by quercetin. Collagen and fibronectin biosynthesis is increased that help to maintain not only healthy joints, but also to speed up the healing of wounds and repair damaged nerves. It is also believed that quercetin can hold back the effects of aging on the skin, and slow down the formation of wrinkles.

    There are other applications of this versatile flavanol, including its effect on acute prostatitis where it reduces oxidative stress and the accompanying inflammation of the prostate gland. In fact, it is believed to have positive effect on many conditions caused by free radical oxidation and excessive reaction by the immune system causing inflammation. Apart from the allergies and arthritis previously referred to, quercetin is believed to have been effectively used in the treatment of gout, macular degeneration and heart disease, and it can also help to prevent the oxidation of low density lipoproteins (LDL) responsible for transporting cholesterol to where it is needed to repair major blood vessels.

    When these lipoproteins become oxidized by free radicals then the cholesterol associated with them tends to be excessively deposited in the arteries it is meant to be repairing, and lead to atherosclerosis. This condition can lead to heart failure or to strokes if the blood vessels are in the brain.

    Studies have indicated that the flavonoid might help to prevent certain cancers by preventing the nutrition of some types of cancerous cells, effectively killing them. Due to its phytoestrogen properties, quercetin can be used to bind to the sites in cancerous cells that are receptive to estrogen and so prevent their growth. Many types of cancerous cells need estrogen for their growth and proliferation, and phytoestrogens mimic the effect of this hormone. However, these are laboratory studies, and more work is required.

    More certain is the effect of quercetin on heart disease due largely to the aforementioned control of cholesterol deposition in your arteries, but also through its ability to strengthen the capillaries. However, when all things are considered, it is in the properties of this non-allergenic bioflavonoid to fight histamine release that it finds it’s most popular and effective use.

    So what is the best way to take quercetin? Like most bioflavonoids, it is available naturally in the majority of plant foods. Particularly rich sources are broccoli, red onions, red apple skins, black tea, red wine, red and purple berries and almost all dark green leafy vegetables.

    However, the name of the game these days is to take measured doses, and while you should continue to eat these foods, you can also receive controlled doses by use of supplements. From 200 to 500 milligrams thrice daily is a good average dose, depending on the severity of your immune reaction or allergy. Bromelain is believed to improve its absorption in the gut, and quercetin is frequently provided with Bromelain, which itself is also a good treatment for allergies and excessive response of your immune system to irritation.

    Bromelain is an enzyme, generally extracted from pineapple, and treatments higher than the above doses of quercetin with or without Bromelain are available online, although like any natural remedy you should inform your own physician of the dosage you are taking.

    There is no better non-allergenic bioflavonoid to fight histamine and its potentially unpleasant effects on your body than quercetin.



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    Are Inflammation, Immunity, And Allergic Reactions A Role For Supplements?
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    Date: November 10, 2007 11:29 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Are Inflammation, Immunity, And Allergic Reactions A Role For Supplements?

    Inflammation, immunity diseases and allergic reactions are all connected with your immune system, and the way the body reacts to what it considers to be foreign invaders that are a risk to your health. Although you may not understand that all three have the basic underlying cause, in fact they do, and here is why.

    Inflammation manifests as pain and swelling in the inflamed area, and not only can the area also get hot, but it can also raise your temperature in general, commonly called a fever. Fever is the body’s way of raising temperature above that at which foreign organisms such as bacteria and viruses can live, so any inflammatory condition that results in fever by definition must be an immune response through the body trying to eliminate foreign invaders.

    If your body gets injured in any way, your immune system responds, and usually calms down again if decides that the injury is not serious. Your immune system is actually initiated by what are known as pro-inflammatory hormones, such as prostaglandins that stimulate the nerves to signal pain and swell the blood vessels close to the injury to make room for the large white blood cells when they arrive. That also allows blood and plasma to rush out and cause swelling at the site of the injury. Other prostaglandins act to quell the immune response, and get your body back to normal.

    Another such hormone is a cytokine, which informs the brain of the intrusion. Some cytokines called leukocytes stop the immune system when necessary to prevent the destruction of healthy tissue, and also halt the inflammatory response. If the leukocytes are not working properly, the body can be severely damaged as the immune system becomes uncontrolled and starts to attack healthy tissue.

    Then there are the histamines that allow you to expel the agents causing the problem by sneezing, watery eyes, runny noses and scratching. They lead lymphatic fluid and blood to the site of the problem in order that the invasion can be attacked and destroyed.

    It is the histamines that provide what is commonly referred to as an allergic reaction, which is really the immune system coming into action to remove invaders such as pollen, dust mites and any other agent that can cause an allergy. Immunity is caused by introducing small amounts of the agent into the blood, so that the immune system can develop a memory of them. Then, when the same invader returns at a later date, the system can immediately attack them with the antibodies that have been produced.

    All of these: inflammation, immunity and allergies, are caused by the reaction of the immune system to what it perceives as an invader. Normally these are bacteria and viruses, but sometimes they react to other foreign bodies such as pollen. In some people this provokes no response at all, while in others it provokes the immune system to create antibodies against the pollen, and emit histamine to expel it.

    Substances that cause allergies are referred to as allergens. Many allergens are environmental, such as dust, pollen and peanuts. Some people are allergic to certain animals, such as cats or dogs, and others to chemicals in the air such as hydrocarbon emissions, particularly when in particulate form.

    The symptoms can be simple, such as a runny nose, a cough and hay fever or more complex such as hives, eczema and asthma. All of these are caused by the immune system reacting to an invader. There are also foods that cause internal inflammation, such as shellfish and whitefish, eggs and tomatoes. Many of these can be extreme, leading to serious illness and can even be fatal. So what can be done to treat people who are particularly prone to inflammation and allergic reactions?

    Omega-3 fatty acids have been found to reduce inflammation, unlike their Omega-6 cousins that appear to increase it. Omega-3 oils contain chemicals known as eicosanoids, of which the prostaglandins are an example. While this might seem paradoxical, since prostaglandins are what set off the whole process, there are many types of these. Prostaglandin E2 is the type that leads to allergic immune reactions, and omega-3 fatty acids reduce the concentration of these in the blood.

    Those who eat little fish tend to suffer more from inflammatory conditions such as arthritis and other conditions indicating a lack of control of the immune system. On the other hand, processed foods contain more omega-6 fatty acids that can promote these conditions. The major components of omega-3 oils are alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) and also DHA, docosahexaenoic acid. These are all anti-inflammatories and have been shown to have very positive effects on inflammatory conditions such as rheumatoid arthritis, Crohn’s disease and eczema. Each of these is a different type of inflammatory condition caused by inappropriate immune response.

    However, it not just fish oils that can help resolve problems with our immune system. Quercetin is what is known as a flavonoid. It is a strong anti-oxidant and natural anti-histamine that combats histamine release and the swelling associated with the immune response to allergens. It also counters the inflammatory agents of arthritis and so helps to reduce the pain associated with many of these conditions. It appears to work better in conjunction with Bromelain, a very powerful anti-inflammatory that also possesses anti-allergen response properties. Bromelain is extracted from pineapple stems.

    Another natural product is a resin extract that is obtained from the Boswellia serrata tree. It has powerful anti-inflammatory properties, and has been recommended for the treatment of arthritis (rheumatoid and osteo), Crohn’s disease and has been suggested as a treatment for asthma, though studies are still under way. However, world wide experience is that Boswellia is effective against gout, psoriasis and ulcerative colitis, to name another three totally different inflammatory conditions.

    What all of this indicates are two things. First that inflammation, immunity and allergic reactions are connected conditions, and due to either poor control over or an over stimulated immune response to what the body perceives as being abnormal, in the way that hormones and other chemicals that are used to control our immunity detect it to be.

    Secondly, there are many natural products that can be used as supplements to treat these effects caused by the immune system, and that their effectiveness has been proven, if not by scientific study, then by generations of traditional application as treatments of the symptoms of the conditions concerned.

    However, although many have been proved by scientific study, others have not, and you should always refer to your physician before undergoing any treatment other than that prescribed. Also, there is incontrovertible evidence that the role for supplements in the treatment of inflammation, immunity and allergic reactions are beneficial. Many use nothing else.

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    Dietary Supplements

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    Are you allergic to what you eat?
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    Date: November 08, 2007 12:45 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Are you allergic to what you eat?

    If you didn’t realize, foods can actually cause an allergic reaction in sensitive individuals. Most of the allergic reactions we experience are due to dietary consumption of common foods like wheat and milk. Food allergies are usually cause by an over active immune system; symptoms range from itchiness, hives, stomach pain, and worst case anaphylactic shock which can be life threatening. A majority of reactions in individuals are actually intolerances where the digestive tract can not handle the foods being consumed such as gluten protein found in wheat. Gluten intolerance is one of the most common food allergies Americans experience. Gluten intolerances can lead to an inflammatory problem in the body which is called celiac disease.

    Discovering and eliminating food allergies is the first step towards relief; there are natural alternatives that may help as well. Vitamins and herbs that may relieve heart burn: aloe vera, chamomile, turmeric, dgl licorice, vitamin B5, Vitamin B1, Choline, marshmallow root, slippery elm, cabbage juice, and zinc may help. A strong probiotic and FOS may help indigestion. Enzymes like papain and Bromelain as well as peppermint and ginger can ease stomach ache. Irritable Bowel Syndrome (IBS) affects millions of individuals on a daily basis; natural remedies that may help are ginseng, rhodiola, and fiber.

    There are many alternatives to prescription anti-acids available to try, take some time and explore these alternatives to experience a more natural alternative for relief with zero side effects.

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    Do you experience muscle pain and inflammation?
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    Date: April 25, 2007 03:30 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Do you experience muscle pain and inflammation?

    FlexAgility MAX

     

    Everyone experiences muscle pain and inflammation due to overuse and exertion. We’ve all had those softball games, weekend camping trips or chore-intensive days when our body lets us know we’ve overdone it.

    So, what can you do about it? Well, fortunately, there is a proprietary formula with clinically studied ingredients that provides a natural solution: FlexAgility MAX.

    FlexAgility MAX is designed to reduce pain and inflammation due to overuse. Its clinically studied ingredients have been shown to help balance the body’s own inflammatory response. Let’s take a look at FlexAgility MAX and answer a few questions you may have about it.

     

    Q. What is inflammation? Why does it happen?

    A. Inflammation is actually an essential part of your body’s natural healing process. When some form of physical stress affects the body, the immune system responds by supplying defensive compounds to the stressed site. This is what causes the fluid build-up, pain and redness we typically associate with inflammation. And until the situation is resolved those symptoms will stick around. So, why is that good? Because without these signals – pain and inflammation – we’d probably do even more damage. In a sense, pain and inflammation are very effective stop signs.

    The problem is, if our bodies are continuously bombarded by factors that trigger inflammation, these defenders (and their symptoms) are always around. This can mean unnecessary pain and inflammation following overuse and exertion.

     

    Q. What does FlexAgility MAX have to do with inflammation?

    A. FlexAgility MAX provides triple-action activity against occasional pain and inflammation, with powerful antioxidant free-radical scavengers, the enzyme Bromelain, and a natural COX-2 inhibitor.

     

    Q. So what is COX-2 and why should I inhibit it?

    A. We’ve all been hearing a lot in the news about COX-2 inhibition and may have wondered about its connection to pain and inflammation. Let’s take a look:

    Cyclooxygenase is an enzyme that comes in two main types, abbreviated for convenience: COX-1 and COX-2. The COX enzymes regulate compounds involved with inflammation, including prostaglandins. COX-1 is found throughout the body, and maintains the integrity of the stomach lining, circulation and kidneys.

    COX-2 on the other hand, cruises along the central nervous system – it’s much more attuned to our brain’s sense of “what hurts.” Primarily activated by inflammatory stress, COX-2 generates prostaglandins – the hormone-like defensive compounds that cause the responses we associate with pain and inflammation due to overuse.

    You can understand why so much research has focused on COX-2 inhibition. Decreasing its activity means short-circuiting the “inflammation cascade” that follows occasional overuse.

    Because COX-1 is associated with a healthy stomach lining, it is not an enzyme you want to inhibit. Unfortunately, many products don’t know the difference between COX-1 and COX-2 – filing both with one blast.

    Fortunately, there are ingredients in FlexAgility MAX that can tell them apart. One of them is IsoOxygene.

    IsoOxygene is a patented hops extract shown in scientific studies to significantly inhibit COX-2, while leaving COX-1 alone. And, it is a 20 times more potent COX-2 inhibitor than other tested popular botanic products, including curcumin and grape seed.

     

    Q. How do antioxidants support the body during times of inflammation due to overuse?

    A. Overall, the body ahs a pretty darn good repair system. However, oxidative stress due to free radical damage can take its toll, especially during times of occasional physical stress. Free radicals and reactive oxygen species can damage cells, because they are hungry, unstable molecules in search of electrons. To find them, they attack other cells. These pillaged cells then become free radicals themselves, setting off a chain reaction of oxidative stress.

    Free radicals are formed during the body’s normal functions, and can have benefits, such as neutralizing viruses and bacteria. However, in doing do, they erode the body’s own antioxidant defenses, too. And, free radicals typically become very active during times of inflammation due to overuse or other stressors.

    The good news is that the herbal and antioxidant elements in FlexAgility MAX help support the body’s own natural anti-inflammatory defenses.

    Take vitamin C, for instance. This extremely well-known antioxidant has been scientifically studied for its beneficial effects on muscle, collagen and connective tissue health. Collagen and connective tissue is what helps hold us together – literally.

    And famous antioxidant, green tea, has been well-studied for the benefits of a polyphenol called epigallocatechin-3-gallate, or simply EGCG. In scientific and clinical studies, EGCG from green tea works as an overall antioxidant, scavenging free radicals, and supporting healthy collagen. In fact, one study showed that green tea polyphenols supported collagen health by 50% versus only 16% in controls.

    The green tea extract in FlexAgility MAX is especially focused on these beneficial polyphenols. It’s standardized to contain 70% polyphenols – half from EGCG. The green tea acts in concert with elderberry and ginger in the formula to help prevent oxidative stress to the body due to occasional overuse.

    Anthocyanins are natural antioxidants found in berries and vegetables. Black elderberry extract, one of the herbal ingredients in FlexAgility MAX, was shown in scientific studies to be more bioavailable – that is, more readily used by the body – than the natural bioflavonoids of other plants. Again, antioxidants help keep the body in optimum health- especially during times of physical stress.

     

    Ginger, used for centuries in Ayurvedic medicine, provides strong, natural antioxidant activity. In fact, a recent scientific study found more than 50 separate antioxidants in ginger root.

    Of course, there are many components of plants that show strong antioxidant properties. A scientific study comparing flavonoid antioxidant activity and inflammation have shown that rutin was the most effective in reducing the inflammation cascade.

     

    Boswellia serrata is a tree found growing in the dry, hilly regions of India. Extracts of boswellia have been used in Ayurvedic practice for centuries. Boswellia also has antioxidant properties that help reduce free radical damage.

    Another antioxidant ingredient in FlexAgility MAX, N-acetylcysteine (NAC), even helps the body produce more of its own antioxidants, cysteine and glutathione. In a double-blind, placebo-controlled clinical study, N-acetylcysteine inhibited occasional pain and inflammation due to overuse and attenuated fatigue by 26% compared to controls!

    N-acetylcysteine has also been shown in scientific tests to act as an antioxidant, supporting healthy collagen and synovial fluid.

    The last ingredient, Bromelain, provides the enzymatic pathway used by FlexAgility MAX. Bromelain is a proteolytic enzyme derived from pineapple. Clinical and scientific studies showed benefits from Bromelain in reducing pain and inflammation from occasional overuse.

    So, there you have it- the triple action of FlexAgility MAX: COX-2 inhibition (and COX-1 sparing), antioxidant benefits, and enzyme support.

     

    Q. Is there another product you’d recommend that I use with FlexAgility MAX?

    A. One other product I recommend without hesitation is GS-500, a glucosamine sulfate supplement that has been shown to help build and support cartilage. The body’s connective tissue and cartilage include a natural compound called glucosamine. Supplemental glucosamine sulfate is up to 98% absorbable, so more glucosamine reaches the target structures. It has been clinically studied on its effect in building cartilage.

     

     

    About Enzymatic Therapy:

     

    Like Chris, Enzymatic Therapy is a trailblazer. Since our founding in 1981, we’ve been leading the industry with innovative natural products. After all, in 1993, Enzymatic Therapy introduced glucosamine sulfate, shown to help build and support cartilage, to the United States. Our product, GS-500, is up to 98% absorbable, so more glucosamine reaches the target structures.

    In the intervening years, Enzymatic Therapy has been at the frontline of innovation and invention. Many revolutionary precuts, including Saventaro, Cell Forte, Heartburn Free, Petadolex Patented Brain Support, Whole Body Cleanse, Earth’s Promise, Hot Plants for Him and Hot Plants for Her have been introduced by Enzymatic Therapy.

    One of the newest products, (and the reason you’re reading this) is FlexAgility MAX. FlexAgility MAX works with the body’s own natural anti-inflammatory pathways to relieve pain and reduce inflammation due to occasional overuse. Our proprietary FlexBend of ingredients, combined with antioxidants and the proteolytic enzyme, Bromelain, is unique among natural products.



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    Degenerative joint disease (osteoarthritis)
    TopPreviousNext

    Date: August 24, 2006 03:55 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Degenerative joint disease (osteoarthritis)

    Degenerative joint disease (osteoarthritis) damages or destroys cartilage and its supportive collagen structure. As many as 40 million Americans, including the majority of people over age fifty, are thought to suffer from some form of this disease. Primary osteoarthritis, the “wear and tear” form, is due to normal use and age-related causes. Secondary osteoarthritis results from repeated joint trauma, inherited predisposition, or previous inflammatory conditions. While non-steroidal anti-inflammatory drugs (NSAIDs) treat symptoms only, a natural, holistic approach strives to improve the environment of the cartilage and joint as a whole by providing protective and restorative nourishment, increased circulation, decreased inflammation and reduced free radical damage.

    High levels of Glucosamine and Chondroitin Sulfate

    Widely regarded as the first defense in protecting joints, glucosamine and Chondroitin sulfate have been shown to effectively control joint pain and slow down or reverse the progression of cartilage deterioration. The integrity of joint gliding surfaces as well as the health of tendons, ligaments, joint fluids, skin, bones, heart valves and virtually all structural elements in the body is dependent upon the proper synthesis and availability of proteoglycans, integral components of joint cartilage.

    Glucosamine provides two components critical to the synthesis of proteoglycans: hyaluronic acid and glycosaminoglycans (GAGs).

    Chondroitin sulfate represents an important group of GAGs. It is not a single compound, but rather a class of compounds with different molecular weights that each have specialized functions within the body.

    Numerous studies have shown that long-term safety, reduction in pain and protection of cartilage with body chondroitin and glucosamine are comparable or superior to results obtained with NSAIDs.

    MSM. (Methylsulfonylmethane) MSM is a rich source of sulfur, a mineral required for GAG synthesis. A preliminary study suggests that MSM may help reduce pain in persons with degenerative arthritis.

    Gota Kola. (Centella asiatica) known to support collagen synthesis and stimulate GAG’s, Gota Kola has been used for many years in Europe to promote wound healing and blood vessel integrity. It also has been shown to improve circulation in small vessels.

    Turmeric. (Curcuma longa) this saffron-colored root offers a wide range of benefits. It naturally inhibits the inflammatory COX-2 enzyme, reduces pain and is a potent antioxidant that protects the liver and other cells. High antioxidant diets may inhibit joint deterioration.

    Bromelain. Derived from pineapple cores, Bromelain is most commonly used for healing soft tissue injuries and inflammation. It contains potent selective proteases (protein-digesting enzymes) and other substances which serve to block destruction of GAGs.

    Trace Minerals. Micronutrients play many distinct roles in support of healthy joint connective tissue and joint cartilage matrix.

    Black Pepper Extract. Bioperine is a highly concentrated extract (95% - 98% piperine) of black pepper. Used as a bioavailability enhancer, it has been shown to increase the absorption of vitamins, minerals and herbs.



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    Solaray Vitamins

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    Rutozym - Systemic Enzyme Supplement with Nattokinase
    TopPreviousNext

    Date: February 22, 2006 05:08 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Rutozym - Systemic Enzyme Supplement with Nattokinase

    Wobenzyme / Naturally Vitamins

    Choose all-vegetarian Rutozym for smoother blood flow, stronger blood vessel walls, and a pacified inflammatory response.

    Take Control of Your Heart Health

    Heart disease claims an American life every 34 seconds, making heart disease the leading cause of death in the United States. Not only men, but also one out of every two women are affected by heart disease and stroke.

    According to the American Heart Association, misperceptions about the risks of cardiovascular disease for women still exist, even though 50 percent of people with heart disease today are women, and more women than men die of stroke. After menopause, women are even more likely to have heart attacks than men.

    Because of today’s standard of American fast-food diets and poor lifestyle habits, many people have high cholesterol and hypertension and suffer from circulatory disorders. People with excessive body fat are more likely to develop heart disease and stroke, even if they have no other risk factors. Obesity increases the strain on the heart, which contributes to coronary heart disease and can also make diabetes more likely to develop.

    People in many other countries have somehow managed to maintain healthier hearts naturally. One reason may be the enzymes in their diet.

    Nattokinase and Cardiovascular Health Experts credit much of Japan’s reputation for the lowest heart disease rate to nattokinase, an enzyme in the fermented soy-based cheese called natto. Although a Japanese staple for over 2000 years, the sticky, odorous cheese is, needless to say, an acquired taste. Fortunately the advantage is in the enzyme, now available in Rutozym.

    Hiroyuki Sumi, MD, a researcher of the Japan Ministry of Education, discovered the enzyme and its remarkable benefits while searching for a natural way to break down excess fibrin in the blood, a major cause of heart disease, stroke, senility and even sudden death. Pleased with how successfully it dissolved fibrin and improved blood flow, Sumi (affectionately known as “Dr. Natto”) gave nattokinase its name.

    Rutozym

    In the 1980s when the story of systemic enzyme therapy was well underway, scientists invited Dr. Karl Ransberger, founder of the enzyme formula Wobenzym, to Japan to present his discoveries in enzyme research. The country’s low rate of heart attacks and its dietary link to natto intrigued Dr. Ransberger. Eager to investigate its potential use in alternative healthcare, he carried several pounds of natto home to Europe. After years of testing, his research confirmed that nattokinase did, in fact, improve blood flow by removing cross-linked fibrin from the blood stream.

    Based on his nearly five decades of experience with the proteolytic Natural Support for Cardiovascular Health (protein-splitting) enzymes in Wobenzym, Dr. Ransberger knew that an enzyme mixture would prove even more effective than a single enzyme formula. So, to the nattokinase he added two of the enzymes in Wobenzym known to normalize inflammation. Then he increased its total effect with a proprietary flavonoid complex. As a result, the formula not only improved blood flow, it strengthened the integrity of blood vessels and helped manage the body’s systemic inflammatory response, promoting better overall health. Dr. Ransberger teamed up with Naturally Vitamins to further develop, test and perfect the Rutozym formula.

    Today, Dr. Ransberger’s legacy lives on through Naturally Vitamins’ continuing research on systemic enzyme therapies. Most recently, Naturally began a 2003 clinical trial in Chicago to evaluate the benefits of Rutozym in heart patients. In cooperation with the leading manufacturer of Nattokinase in Japan, the trial will examine the effects of Rutozym on blood viscosity (thickness) and blood pressure. On completion, the results will be published in a peer-reviewed journal.

    How Rutozym Works

    Rutozym works by reinforcing your body’s own enzymes. As the building blocks of life, enzymes make every chemical action in the body possible. Though you are born with thousands of enzymes, as time goes by your supply diminishes. Scientific research shows that replenishing your natural supply with systemic enzymes can support your body’s immune functions and healing processes.

    Rutozym is a plant-based systemic enzyme formula containing nattokinase. But it also contains other proteolytic enzymes and ingredients carefully blended to improve heart health and enhance your body’s innate ability to heal. Rutozym contains the proteolytic enzymes Bromelain (from pineapple) and papain (from papaya) known to effectively rebalance the body’s inflammatory response. Rutozym also contains rutin to strengthen capillaries and other connective tissue, and white willow bark, which is often called “nature's aspirin.”

    While doctors often recommend an aspirin a day to help prevent heart disease and stroke, the daily use of Rutozym has no gastrointestinal side effects. With new research, the scope of Rutozym’s benefits continues to increase. Supplement Facts

    Serving Size: 2 Tablets
    Servings Per Container: 60 amnt/serving %daily
    Nattokinase (20,000 FU/gm) 25mg *
    Bromelain (2,450 GDU/gm) 90mg *
    Papain N.F. (2,400 USP Units/mgl) 100mg *
    Rutin bioflavonoid Complex (rutosides & rutinosides) 120mg *
    White willow bark extract (15% solicin/7% plyphenols) 100mg *

    * Daily value not established.

    Other Ingredients: Plant Fiber, Povidone, Modified Cellulose Gum, Colloidal Silica, Titanium Dioxide Mineral, Vegetable Stearic Acid and pH-Resistant Enteric Coat.

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    What are Papaya Enzymes good for?
    TopPreviousNext

    Date: January 14, 2006 10:27 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: What are Papaya Enzymes good for?

    What are Papaya Enzymes good for?

    NOW® Papaya Enzymes combines natural papaya enzymes with Mint and Chlorophyll. This product is good as a digestive aid, and should help with flatulence and bad breath as well. Since poor digestion can contribute to bad breath, Papaya Enzymes and Chlorophyll may help by supporting healthy digestion. This product is a vegetarian product. Stearic Acid and Magnesium Stearate are natural excipients derived from palm oil.

    After taking NOW® Super Enzymes, I began to experience chronic stomach pains. Is this normal? Should I stop taking this product?

    Does this product contain salicylates?

    NOW® Super Enzymes contains a broad array of digestive enzymes designed to assist your body in the digestion of many different types of food. A few people who use NOW® Super Enzymes experience a reaction to the protein digesting enzymes in this formula (Pancreatin, Bromelain & Papain). Most of the time this occurs because the person had an irritated stomach lining prior to using Super Enzymes, and these particular enzymes may exacerbate this existing condition. Discontinue use of the product if you experience any sort of stomach irritation after beginning supplementation. This product does not contain any salicylates.

    Disclaimer: This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

    (http://vitanetonline.com/forums/Index.cfm?CFApp=1&Message_ID=1185)


    Fight Hay Fever - Help Your Sinus...
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    Date: July 11, 2005 09:15 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Fight Hay Fever - Help Your Sinus...

    HANDLING SPRING(HAY)

    The National Institute of Health’s branch of Allergy and Infectious Diseases re p o rt that 40 to 50 million Americans suffer from allergies in one form or another. Many experience food allergies that a re treated somewhat diff e rently from hay fever allergies. Hay fever comes from airborne allergens, generally from pollen or pollutants.

    The symptoms of allergy occur when an immune system is overactive. The immune system often recognizes something as foreign and treats it as foreign by attacking it, when in fact it really isn’t a substance the body should be concern e d with. This over-activity of the immune system leads to the release of substances including histamine that cause the symptoms of hay fever.

    The most common symptoms include a runny nose and itching eyes and scratchy throat. Sometimes, an allergy will precede a sinus infection by causing swelling in the nasal membranes preventing fluids f rom exiting the sinus passages. An infection then ensues. However, most people who feel pressure over their sinuses, never develop an infection and so can be adequately treated with the supplements mentioned here. Many people experience a tickle or a shallow cough that comes from the throat rather than the lungs. They may also experience a change in emotions, becoming quite irritable or moody.

    These airborne allergies can often be g rouped by season. Those people sensitive to tree pollens usually have more severe allergies in the springtime. Those sensitive to grasses are often worse in mid-summer. Those allergic to weeds have their symptoms peak in the fall. There are some unfortunate people who have allergies all summer long who may be allergic to a few plants in each group. Those who have symptoms of allerg i e s all winter long probably are allergic to molds and mildew or household animals and dust mites. On occasion, it takes a real detective to determine from where the allergies come.

    There are several methods used to diagnose a cause of an allergy. In a scratch test, drops of an allergen are put on small scratches on the arm or the back. Are action is considered positive if swelling or redness occur around the scratch. A blood sample can also be used to meas ure antibody response to certain allergens. It is often helpful to determine the allergen which cause the hayfever to reduce the symptoms. There are also practitioners who use kinesiology or electronic devices to determine the cause of allergies.

    The most common treatment of allergies is with antihistamines. Their side effects include drowsiness and drying of the mucous membranes of the nose and mouth. Many of the newer prescription antihistamines don’t cause drying but often have serious drug interactions and the consumer must be very careful in combining the prescription antihistamines with antifungal drugs, and blood thinning as well as asthma medication. There are some natural products that can be taken to decrease allergy symptoms. They are often equally effective without the side effects of antihistamines.

    QUERCETIN

    One of the more popular is quercetin. Quercetin is a bioflavonoid found in red apples, red onions, brussels sprouts, kale, peas, bell peppers, pears and asparagus. It is also found in bee pollen and propolis, two plant materials found in the beehive. It is possible to consume a fair amount of quercetin through your diet. If you have allergies, however, diet is often not enough and you may need a supplement to get enough quercetin to ontrol your symptoms. It appears quercetin decreases allergic symptoms by stopping the release of histamine. If you start taking quercetin and other nutritional supplements I will mention below before an allergy attack, they are likely to be more effective. However, don’t let that discourage you from taking them even after the symptoms have started. A common dose is 300mg to 600mg per day.

    Bromelain

    Bromelain is a nutrient often extracted f rom pineapple. Found in many digestive formulas, it is an enzyme that helps absorption. If it is found in a combination formula, chances are, it is there to help with the absorption of the other nutrients such as quercetin. Bromelain also has an anti-inflammatory effect. When someone develops allergy symptoms, part of the reason is due to the inflammatory response to substances such as histamine that are released as the allergy takes hold. This causes inflammation in the tissues which then manifests with redness and swelling.

    VITAMIN C

    Vitamin C is useful in many conditions including hay fever. Higher doses are often required in the treatment of allergies: 2,000mg is beneficial and you can take up to 4,000mg or more during acute symptoms. It also stabilizes capillaries, reducing the swelling in the throat, nasal passages and around the eyes. If you are taking a multi-vitamin or a combination product that contains Vitamin C, I still recommend additional supplementation.

    NETTLE (URTICA DIOICA)

    Stinging nettle is probably a plant many a re familiar with, especially if it has come into contact with your skin, but it also has an historical use in the treatment of allergy. In fact, in double blind studies it was shown to decrease the symptoms of allergy, specifically runny nose.

    EPHEDRA (MA HUANG)

    The active component of the ephedra herb is ephedrine, an alkaloid. It is used in OTC asthma medication. As a natural herb, ephedra in small doses can be v e ry useful in decreasing the symptoms of colds, asthma, cough and in this case, hay fever. It is in many Chinese and American formulas that I use and I feel v e ry comfortable using 100mg to 200mg of ephedra that contain small doses of 2.5mg to 8mg of ephedra alkaloids per day. I feel comfortable using dosages of up to 15mg of ephedra alkaloids .

    FEVERFEW

    Feverfew is another herb with a variety of uses. You will find it in headache formulas, in fever reducing formulas, and many hay fever formulas. Like Bromelain, it has an anti-inflammatory effect and reduces the swelling that occurs during a hay fever attack.

    Homeopathic formulas can also be useful to reduce hay fever. There is no re ason why the herbs I’ve mentioned cannot be combined with homeopathic formulas. You may want to take them at separate times of the day.

    So, if you suffer from hay fever, don’t give up. You can use these nutrients singly or in combination. You can take a formula that contains all of them and then add to that additional vitamin C for instance, or additional nettle. It may require trial and error to find the right amounts in combination that will work for you.



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    Quercetin and Bromelain - for better health.
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    Date: July 04, 2005 10:28 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Quercetin and Bromelain - for better health.

  • Maintains Tissue Comfort by Regulating Enzymes*
  • Helps Maintain Normal Blood Viscosity*
  • Bromelain May Enhance Quercetin Absorption
  • Benefits

    Down-regulates the Body’s Response to Environmental Challenges Quercetin is a member of the flavonoid family, a diverse group of low molecular-weight compounds found throughout the plant kingdom. Flavonoids exhibit numerous biological activities, many of which are directly beneficial to human health. Quercetin, which belongs to the “flavonol” subgroup, is one of the most versatile and important flavonoids. Quercetin has a broad range of activity, much of which stems from its interaction with calmodulin, a calcium-regulatory protein.1 Calmodulin transports calcium ions across cellular membranes, initiating numerous cellular processes. Quercetin appears to act as a calmodulin antagonist.1 Through this mechanism, quercetin functions at the cell-membrane level with a membrane-stabilizing action.2 Quercetin inhibits calmodulin-dependent enzymes present at cell membranes such as ATPases and phospholipase, thereby influencing membrane permeability.3 Quercetin affects other calmodulin-dependent enzymes that control various cellular functions, including the secretion of histamine from mast cells.4 A number of investigations have corroborated quercetin’s ability to reduce histamine secretion from mast cells in various tissues, and also from basophils.5,6,7,8,9,10

    Quercetin modifies the body’s response to antigenic substances.* Suppression of histamine secretion from mast cells is one of quercetin’s most clinically important effects. Quercetin acts on ATPase at the membranes of histamine-containing granules in mast cells.3 Mast-cell degranulation and subsequent release of histamine into the bloodstream is an integral part of the body’s response to environmental challenges.

    Maintains Tissue Comfort by Regulating Enzymes*

    Quercetin’s enzyme-inhibiting action extends to enzymes such as phospholipase, which catalyzes the release of arachidonic acid from phospholipids stored in cell membranes.4,10 Arachidonic acid serves as the key substrate for substances such as thromboxanes, inflammatory prostaglandins and leukotrienes. In addition, quercetin inhibits the enzymes cyclooxygenase and lipoxygenase, which catalyze the conversion of arachidonic acid into its metabolites.4,10,11,12 Reducing levels of these metabolites, as well as histamine levels, is beneficial in maintaining the normal comfort level of body tissues and structures.

    Quercetin has also been shown to limit the function of adhesion molecules on endothelial cells.13 Adhesion molecules are involved in physiologic processes that influence tissue comfort.13

    Bromelain is a complex substance derived from the pineapple stem largely composed of proteolytic (protein-digesting) enzymes. Bromelain acts by a variety of mechanisms to help maintain tissues in a normal state of comfort.14,15 Several investigators, including Taussig16 and Ako, et. al.,17 have presented evidence that Bromelain is a fibrinolytic agent, i.e., it induces the breakdown of fibrin, a plasma protein that blocks tissue drainage. The generally accepted mechanisms involve direct proteolysis of fibrin by Bromelain and activation of plasmin, a serum protease.16 Plasmin acts on fibrinogen (the precursor to fibrin), forming peptides which stimulate PGE1, a prostaglandin that helps maintain tissue comfort.16

    Helps Maintain Health of Blood Vessels by Modifying Oxidation of LDL Cholesterol* — Quercetin’s Antioxidant Action Quercetin is a versatile and effective antioxidant that scavenges a variety of free-radicals such as hydroxyl and lipid peroxy radicals.18 Quercetin also chelates ions of transition metals such as iron, which can initiate formation of oxygen free radicals.18 LDL cholesterol is vulnerable to oxidation by lipid peroxides. Oxidized LDL is absorbed by macrophages and arterial endothelial cells, leading to the formation of “foam cells,” and eventually plaque deposits, in arterial walls. Quercetin has been shown to protect LDL from oxidation, both by lipid peroxides and transition metal ions.19

    Helps Maintain Normal Blood Viscosity*

    Quercetin inhibits blood platelet aggregation (clumping), by potentiating PGI2, an anti-aggregatory prostaglandin, and by raising platelet cyclic AMP levels.20 Human studies have revealed that Bromelain also reduces platelet aggregation.21 These properties qualify both quercetin and Bromelain as valuable dietary ingredients for maintaining cardiovascular health.*

    Bromelain May Enhance Quercetin Absorption

    In addition to the actions described above that support the effects of quercetin, Bromelain may also assist the absorption of quercetin in the G.I. tract. (Quercetin is generally believed to be poorly absorbed, although a recent study by Hollman et. al.,22 which concluded that humans do in fact absorb appreciable amounts of quercetin, contradicts this assumption.) Studies have shown that Bromelain enhances absorption of antibiotics, presumably by increasing permeability of the gut wall.23, 24 Given that quercetin is a low molecular-weight compound, it is plausible that simultaneously ingested Bromelain likewise enhances quercetin absorption.

  • *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • Scientific References

    1. Nishino, H., et. al., “Quercetin interacts with calmodulin, a calcium regulatory protein.” Experientia 1984;40:184-5.
    2. Busse, W.W., Kopp, D.E., Middleton, E., “Flavonoid modulation of human neutrophil function.” J. Allergy Clin. Immunol. 1984;73:801-9.
    3. Havsteen, B,. “Flavonoids, a class of natural products of high pharmacological potency.” Biochemical Pharmacology 1983;32(7):1141-48.
    4. Middleton, E., “The Flavonoids.” Trends in Pharmaceutical Sciences 1984;5:335-8.
    5. Otsuka, H. et. al., “Histochemical and functional characteristics of metachromatic cells in the nasal epithelium in allergic rhinitis: Studies of nasal scrapings and their dispersed cells.” J. Allergy Clin. Immunol.1995;96:528-36.
    6. Fox, C.C., et. al., “Comparison of human lung and intestinal mast cells.” J. Allergy and Clin. Immunol. 1988;81:89-94.
    7. Pearce, F.L., Befus, A.D., Bienenstock, J., “Mucosal mast cells III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells.” J. Allergy and Clin. Immunol. 1984;73:819-23.
    8. Middleton, E. Drzewiecki, G., Krishnarao, D., “Quercetin: an inhibitor of antigen-induced human basophil histamine release.” J. of Immunology 1981;127(2):546-50.
    9. Bennett, J.P., Gomperts, B.D., Wollenweber, E.,“ Inhibitory effects of natural flavonoids on secretion from mast cell and neutrophils.” Arzneim. Forsch/Drug Res. 1981;31(3):433-7.
    10. Middleton, E. Drzewiecki G., “Naturally occurring flavonoids and human basophil histamine release.” Int. Archs Allergy appl. Immun. 1985;77:155-7.
    11. Yoshimoto, T. et. al., “Flavonoids: potent inhibitors of arachidonate 5-lipoxygenase.” Biochemical and Biophysical Research Communications 1983;116(2):612-18.
    12. Della Loggia, R., et. al., “Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo- and lipo-oxygenase.” Pharmacological Research Communications 1988; 20(Supp. V):91-94.
    13. Middleton, E., Suresh, A., “Quercetin inhibits lipopolysaccharide-induced expression of endothelial cell intracellular adhesion molecule-1.” Int. Arch. Allergy Immunol. 1995;107:435-6.
    14. Taussig, S.J., Batkin, S., “Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application.” An Update Journal of Ethnopharmacology 1988;22:191-203.
    15. Lotz-Winter, H., “On the pharmacology of Bromelain: An update with special regard to animal studies on dose-dependent effects.” Planta Medica 1990;56:249-53.
    16. Taussig, S.J., “The mechanism of the physiological action of Bromelain” Medical Hypothesis 1980;6:99-104.
    17. Ako, H. Cheung, A.H.S., Matsuura, P.K., “Isolation of a fibrinolysis activator from commercial Bromelain.” Arch. Int. Pharmacodyn. 1981;284:157-67.
    18. Afanas’ev, I.B. et. al., “Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation.” Biochemical Pharmacology 1989;38(11):1763-69.
    19. De Whalley, C.V., “Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages.” Biochemical Pharmacology 39(11):1743-50.
    20. Beretz, A. Stierle, A., Anton, R. Cazenave, J., “Role of cyclic AMP in the inhibition of human platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin.” Biochemical Pharmacology 1981;31(22):3597-600.
    21. Heinicke, R. van der Wal, L. Yokoyama, M., “Effect of Bromelain (Ananase®) on human platelet aggregation. ”Experientia 1972;28(7):844.
    22. Hollma, P. et. al., “Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers.” Am. J. Clin. Nutr. 1995;62:1276-82.
    23. Giller, F.B., “The effects of Bromelain on levels of penicillin in the cerebrospinal fluid of rabbits.” A., J. Pharm. 1962;134:238-244.
    24. Bodi, T., “The effect of oral Bromelain on tissue permeability to antibiotics and pain response to bradykinin; double-blind studies on human subjects.” Clin. Med. 1965;72:61-65



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    Digest Active - For Occasional Indigestion
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    Date: June 29, 2005 02:39 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Digest Active - For Occasional Indigestion

    It feels great when you’ve eaten well and your body has been energized with nutrients. But with your busy schedule, you might not always be able to eat well, and your body might not have the time or energy to properly digest your meals. The result: occasional indigestion and low energy because your food doesn’t get broken down enough to release the energizing nutrients you need. And poor digestion can lead to long-term health imbalances. To reclaim the energy from your nutrients, Source Naturals, the science company, introduces DIGESTACTIV, a Bio-Aligned Formula™ designed to work with your body to stimulate optimal digestion. DIGESTACTIV contains the high potency, broad-spectrum blend of digestive enzymes found in our best-selling ESSENTIAL ENZYMES™, plus digestion-stimulating ingredients such as Bromelain, papain and ginger. When you want digestive stimulation along with the nutrient releasing power of ESSENTIAL ENZYMES for occasional indigestion, take DIGESTACTIVE.

    Bio-Aligned™ Digestive Support

    DIGESTACTIV™ is scientifically formulated to support the body systems involved in healthy digestion. There are herbs and other ingredients to promote the digestive stimulant system and enzymes to promote the digestive systems for releasing nutrients from food. These ingredients work together to optimize the amount of energizing nutrients you can assimilate from your meals and to relieve occasional indigestion, occasional constipation, sour stomach, bloating and gas.

    Digestive Stimulant System

    DIGESTACTIV contains many ingredients that help stimulate your digestive process to promote healthy nutrient accessibility. Betaine HCl (hydrochloric acid) supports the acidic environment needed in your stomach to digest food. The bitter herbs gentian, ginger, peppermint and quassia all stimulate the appetite and the gastric juices needed for digestion. Bioperine® is a pepper extract that increases thermogenic, or heat generating reactions in the gastro-intestinal tract, which facilitates enhanced bioavailability of nutrients.

    Nutrient Digestion Systems

    DIGESTACTIV also contains enzymes that work throughout the varying sections and pH (or acidity) levels of your digestive system. For the carbohydrate digestive system, there are amylase, amyloglucosidase and lactase. Amylase and amyloglucosidase convert starch into smaller, simpler sugars. Lactase breaks down the milk sugar lactose, which many adults are unable to digest. For the protein digestive system, there are acid stable protease and vegetarian pancreatin to promote protein digestion in a wide range of pH levels. Additional protein digestion support comes from the pineapple enzyme Bromelain, the papaya enzyme papain, and betaine HCl, which promotes the acidity level needed to denature proteins for digestion of their building blocks, amino acids. For the fat digestive system, there is lipase to promote the healthy breakdown of fats, or triglycerides, into their nutrient building blocks, fatty acids and glycerol.

    For the fiber digestive system, there are cellulase and hemicellulase to break down the sturdy cell walls in fibrous plants, thereby releasing more nutrients for digestion.

    Popular Efficacy

    DIGESTACTIV contains all the key ingredients found in the best-selling ESSENTIAL ENZYMES™. ESSENTIAL ENZYMES is a popular product because it addresses body systems in addition to symptoms* of digestive imbalance. And it works. Increasing the breakdown of nutrients in the digestive system results in fewer digestive symptoms* as well as better nutrient availability. And DIGESTACTIV has added enzymes and herbs to promote digestive stimulation for relief of occasional indigestion. Source Naturals is pleased to partner with your local health food store to bring you the unique health benefits of DIGESTACTIV. There is a revolution underway in how we think about and maintain our health, and natural food stores and outlets are at the forefront. You can benefit right now—long before word spreads to the general public—with the innovative nutrition of Source Naturals DIGESTACTIVE.

    Health Strategies for Digestive Wellness

  • • Eat slowly to give your body time to generate digestive juices as well as savor your food.
  • • Eat a balanced, whole foods diet to maximize your access to energizing bioavailable nutrients.
  • • Drink plenty of water to supply much needed fluid for digestion.
  • • Try to relax when eating, to promote the flow of your digestive juices.
  • • Stay active, because regular exercise helps to promote healthy digestion.
  • • Eat plenty of fiber to provide your GI tract with the bulk needed for healthy digestion.
  • • Eat probiotics, beneficial bacteria that help you digest foods These include acidophilus, which is found in yogurt, and bifidus.
  • • Eat prebiotic carbohydrates found in fruits and vegetables, such as FOS (fructooligosaccharides), to feed the friendly bacteria that live in your intestines and help your digestion.
  • • Supplement your diet with digestion promoting products such as Source Naturals probiotics ACIDOPHILUS, LIFE FLORA™, SUPER CARROT ACIDOPHILUS™, and BIFIDYN™, prebiotic NUTRAFLORA® FOS, and fibers such as CHOLESFIBER™, GRAPEFRUIT PECTIN, GUAR GUM, OAT BRAN 1000™, and PSYLLIUM HUSK POWDER.

    DigestActiv™ is a Bio-Aligned Formula™ Multi-System Support for Occasional Indigestion

    Carbohydrate Digestive System: Amylase, Amyloglucosidase, Lactase

    Protein Digestive System: Vegetal Analog of Pancreatin, Acid Stable Protease, Bromelain, Papain, Betaine HCl

    Fat Digestive System: Lipase

    Digestive Stimulant System: Betaine HCl, Bioperine®, Gentian Root, Ginger, Peppermint, Quassia

    References
    Bland. J. (1993). Digestive Enzymes. Keats Publishing Co. Holcenberg, J. et al. (1981). Enzymes as Drugs. John Wiley and Sons: New York. 331-340. Linder, M. (1991). Nutritional Biochemistry and Metabolism. Appleton & Lange. * The term symptom as used above refers to the effects of nutrient shortages or imbalances and is not related to the diagnosis, treatment, cure, or prevention of any disease.



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    Bromelain Sinus Ease - Nature's Life
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    Date: June 16, 2005 10:57 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Bromelain Sinus Ease - Nature's Life

    Bromelain Sinus Ease™


     

    Nature's Life Sinus Products:


     

    Sinus cavities are lined with delicate mucous membranes, which act as filters for your respiratory system. Normal sinuse tissues are pink and healthy. For many people, when their sinuses come in contact with allergens, pollutants or harmful micro-organisms, histamines are released as a protective measure by the immune system. Sinuses naturally respond by becoming irritated, red, and inflamed with these healing histamines. This process, called the natural inflammatory response, helps to neutralize and remove the irritants in sinuses cavities. Sometimes, however, the immune system continues to flood the sinuses even after the irritants are removed. Bromelain Sinus Ease™ contains three ingredients that have been shown to enhance the body’s ability to reduce this natural inflammatory response and help clear up sinuses.*

    Bromelain

    Bromelain is a group of protein-digesting enzymes extracted from pineapples (Ananassa sativa). Bromelain breaks down fibrin—a key component of the body’s natural inflammatory response to allergens and other foreign stimuli.* Bromelain also appears to inhibit the natural formation of prostaglandins (hormone-like substances) that trigger the natural inflammatory response.*1  It makes mucus less thick,2  allowing the mucus to drain more easily.*

    Human trials have shown that by breaking down and helping to remove fibrin, Bromelain reduces the discomfort of irritated tissues.*3   Double-blinded trials in patients with irritated sinuses show that the natural inflammatory response is reduced more effectively by concentrated Bromelain than by placebo.*4 ,5 ,6 ,7  In all cases, a majority of people responded well to Bromelain supplements.*

    Bromelain has also helped reduce the dura­tion of the natural inflammatory response after nasal procedures by over 70% in a controlled trial.*8 

    The recommended daily amount of Nature’s Life Sinus Ease™  utilizes 1,200 mg a very high potency Bromelain enzyme which has an activity of 2,880 GDU (Gelatin Digestive Units), or 4,320 MCU (Milk Clotting Units) per serving.

    Vitamin C

    Vitamin C also helps reduce histamine release.*9   Some studies have reported that vitamin C is useful in reducing the natural inflammatory response in nasal passages.*10, 11, 12   The effectiveness of vitamin C in reducing histamine release is still debated, however, because a controlled trial was unable to show consistent effects.*13  Doses up to 2 grams per day have been used by researchers. It may be diffi­cult to show these effects in research trials because vitamin C appears to help only some people without affecting others.*14  Studies, however, clearly show that vitamin C supplementation can lower elevated blood levels of histamines.*15, 16 Nature’s Life adds naturally-buffered vitamin C to Sinus Ease due to its safety, immune-supporting effects and potential effica­cy to reduce histamine release.*

    Quercetin is a bioflavonoid found in many natural foods including citrus fruits, onions, apples, tea and lettuce. As with Bromelain, quercetin helps reduce the natural inflammatory response by inhibiting the natural formation of the pro-inflammatory agents, prostaglandins and leukotrienes (white blood cells).*17,18  Quercetin also helps lessen the natural inflammatory response for children with sensitivities to inhalants.*19  Additionally, quercetin may help reduce the effects of harmful micro-organisms *20  Bioflavonoids at doses of 1,200 mg per day have reduced the natural inflammatory response in human studies in combination with 1,200 mg vitamin C,21 an outcome con­firmed in double-blinded research using 600 mg/day of bioflavonoids and 450 mg/day of vitamin C.*22

    Substances which inhibit the natural inflammatory response rarely target just one part of the body.* While quercetin has yet to be tested in reducing the natural inflammatory response in sinuses specifically, doctors of natural medicine frequently use it for that purpose because of its proven ability to lessen the natural inflammatory response elsewhere in the body.*

    Nature’s Life Sinus Ease™

    Nature’s Life has combined these powerful phytonutrients to make Sinus Ease™. High potency Bromelain, Quercetin and vitamin C work to inhibit the natural pro-inflammatory response and encourage adequate sinus drainage.* No safety concerns have been identified with any of these ingredients.23, 24  It is recommended to take the three capsules per day between meals. Since Bromelain is a proteolytic enzyme, if taken with a meal it will act on the protein in the food rather than the natural pro-inflammatory fibrin, so remember to take it between meals.*  Enjoy the winter season and find relief from allergens throughout the year!  Nature’s Life Sinus Ease™ can help.

    References:

    1.   Taussig SJ. The mechanism of the physiological action of Bromelain. Med Hypoth 1980;6:99-104.

    2. Martin GJ. Bromelain pineapple proteases with anti-edema activity. Exper Med Surg 1962;20:228-48.

    3. Blonstein JL. Control of swelling in boxing injuries. Prac­titioner 1969;203:206.

    4. Seltzer AP. Adjunctive use of Bromelains in sinusitis: a controlled study. EENT Monthly 1967;46:1281-8.

    5. Taub SJ. The use of Ananase in sinusitis—a study of 60 patients. EENT Monthly 1966;45:96-8.

    6. Ryan RE. A double-blind clinical evaluation of Bromelains in the treatment of acute sinusitis. Headache 1967;7:13-7.

    7. Taub SJ. The use of Bromelains in sinusitis: a double-blind clinical evaluation. EENT Monthly 1967;46:361-5.

    8. Seltzer AP. Minimizing post-operative edema and ecchymoses by the use of an oral enzyme preparation (Bromelain). EENT Monthly 1962;41:813-7.

    9. Johnson CS, Martin LJ, Cai X. Antihistamine effect of sup­plemental ascorbic acid and neutrophil chemotaxis. J Am Coll Nutr 1992;11:172-6.

    10. Zuskin E, Lewis AJ, Bouhuys A. Inhibition of histamine-induced airways constriction by ascorbic acid. J Allergy Clin Immunol 1973;51:218.

    11. Ruskin SL. High dose vitamin C in allergy. Am J Dig Dis 1945;12:281.

    12. Holmes HN. Hay fever and vitamin C. Science 1942;96;497.

    13. Fortner BR, Danziger RE, Rabinowitz PS, Nelson HS. The effect of ascorbic acid on cutaneous and nasal response to histamine  and allergen. J Allergy Clin Immunol 1982;69:484-8.

    14. Bai TR, Martin JG. Effects of indomethacin and ascorbic acid on histamine induced bronchoconstriction in normal  subjects. NZ  Med J 1986;99:163 [abstr].

    15. Holmes H, Alexander W. Hay Fever and Vitamin C. Science 1942;96:497-99.

    16. Johnston CS, Martin LJ, Xi C. Antihistamine Effect of Supplemental Ascorbic Acid and Neutrophil Chemotaxis. J Am Coll Nutr 1992;11:172-6.

    17. Middleton E, Drzewieki G. Naturally occurring flavonoids and human basophil histamine release. Arch Allergy Applied Immunol 1985;77:155-7.

    18. Welton AF, Tobias LD, Fiedler-Nagy C, et al. Effect of flavonoids on arachidonic acid metabolism. Prog Clin BiolRes 1986;213:231-42

    19. Balabokin II, Gordeeva GF, Fuseva ED, et al. Use of vitamins in allergic illnesses in children. Vopr Med Khim (Russia) 1992;38:36-40.

    20. Ohnishi E, Bannai H. Quercetin potentiates TNF-induced antiviral activity. Antiviral Res 1993;22:327-31.

    21. Miller MJ. Injuries to athletes. Med Times 1960;88:313-6.

    22. Cragin RB. The use of bioflavonoids in the prevention and treatment of athletic injuries. Med Times 1962;529-32.

    23. Taussig SJ, Yokoyama MM, Chinen N, et al. Bromelain: A proteolytic enzyme and its clinical application. Hiroshima J Med Sci 1975;24:185-193.

    24. Hertog MGL, Feskens EJM, Holman PCH, et al. Dietary flavonoids and cancer risk in the Zutphen elderly study. Nutr Cancer 1994;22:175-84.

     

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