. . synergistically works to reduce sinus pain and the body's natural
Bromelain, Quercetin and Vitamin C
helps reduce swelling and inflammatory
response to sinuses by increasing the body's ability to break
thins mucus allowing sinuses to drain more easily2*
C has mild antihistamine activity3*
C, when given with bioflavonoids like quercetin, has reduced the
a potent plant bioflavonoid, eases painful inflammatory response5*
Benefits of Sinus Ease
Sinus cavities are lined with delicate mucous membranes, which act
as filters for your respiratory system. When attacked by allergies,
pollutants, viruses or bacteria, they respond by becoming swollen and
Bromelain helps inhibit
the formation of prostaglandins that trigger the inflammatory response.6*
It also makes mucus less thick, allowing mucus to drain more easily.2*
Fibrin is a protein that concentrates in areas of inflammation, causing
painful swelling.* Bromelain decreases fibrin deposits, preventing
damaging buildup in the sinuses and elsewhere.1*
Human trials have shown that by removing fibrin from areas of
inflammation, bromelain lessens swelling.1* Inflamed sinuses respond well
to bromelain.* Double-blinded trials show that the inflammatory response
is better reduced by bromelain than by placebo.7,8,9,10* In all cases, a
majority of people responded well to bromelain supplements.*
Quercetin reduces the
inflammatory response by inhibiting release of pro-inflammatory
leukotrienes, which are similar to prostaglandins.11* Leukotrienes are one
of the most potent pro-inflammatory substances produced by our
bodies—over 3,000 times more powerful than prostaglandins.* Quercetin
also protects white blood cells which, when damaged, release
pro-inflammatory histamine.5* Quercetin may also have anti-viral
Bioflavonoids may help decrease swelling by reducing capillary
fragility and permeability.* In human studies, the inflammatory response
was decreased when bioflavonoids were given in combination with vitamin C,
an outcome confirmed in double-blinded research.4,12*
Vitamin C has mild
antihistamine activity.3,13* As a possible consequence, some studies have
reported that vitamin C is useful in reducing painful, swollen nasal
passages.14,15,16* The effectiveness of vitamin C in producing antihistamine
effects is still debated, however, because a controlled trial was unable
to show consistent effects.17* Doses up to 2 grams per day have been used
by researchers.13* It may be difficult to show these effects in research
trials because vitamin C appears to help only some people without
Bromelain is a
protein-digesting enzyme found in pineapple. Nature’s Life uses high
activity bromelain—each 3 capsules provides 2,880 GDU (4,320 MCU).
Bromelain should be taken on an empty stomach. If taken with food,
bromelain’s activity may be lessened.* When taken without food,
bromelain will be absorbed into the bloodstream and will be available to
help reduce the inflammatory response.* Bromelain is safe; many studies
have reported no side effects, except a mild diarrhea at very high doses.*
Quercetin is a safe, potent
bioflavonoid found in many plants.* Nature’s Life uses quercetin from
the pod of a tropical tree of the Dimorphandra
species. Quercetin is virtually non-toxic but may cause mild diarrhea in
Our Vitamin C is pure,
hypoallergenic calcium ascorbate. Calcium is a very effective buffer. When
combined with ascorbic acid to form calcium ascorbate, it is easier on the
stomach. People who cannot use ascorbic acid because of its acidity, can
usually tolerate calcium ascorbate very well.
Exper Med Surg 1962;20:228-48.
J Am Coll Nutr 1992;11:172-6.
Med Times 1960;88:313-6.
Arch Allergy Applied Immunol 1985;77:155-7.
Med Hypoth 1980;6:99-104.
EENT Monthly 1966;45:96-8.
EENT Monthly 1967;46:361-5.
EENT Monthly 1967;46:1281-8.
Prog Clin Biol Res 1986;213:231-42.
Med Times 1962;529-32.
J Am Diet Assoc 1992;92(8):988-9.
Am J Dig Dis 1945;12:281.
J Allergy Clin Immunol 1973;51:218.
J Allergy Clin Immunol 1982;69:484-8.
NZ Med J 1986;99:163 [abstr].
cavities are lined with delicate mucous membranes, which act as filters
for your respiratory system. Normal sinuse tissues are pink and healthy.
For many people, when their sinuses come in contact with allergens,
pollutants or harmful micro-organisms, histamines are released as a
protective measure by the immune system. Sinuses naturally respond by
becoming irritated, red, and inflamed with these healing histamines.
This process, called the natural inflammatory response, helps to
neutralize and remove the irritants in sinuses cavities. Sometimes,
however, the immune system continues to flood the sinuses even after the
irritants are removed. Bromelain
Sinus Ease™ contains three ingredients that have been shown to
enhance the body’s ability to reduce this natural inflammatory
response and help clear up sinuses.*
is a group of protein-digesting enzymes extracted from pineapples (Ananassa
sativa). Bromelain breaks down fibrin—a key component of the
body’s natural inflammatory response to allergens and other foreign
stimuli.* Bromelain also appears to inhibit the natural formation of
prostaglandins (hormone-like substances) that trigger the natural
inflammatory response.*1 It makes mucus less thick,2
allowing the mucus to drain more easily.*
trials have shown that by breaking down and helping to remove fibrin,
bromelain reduces the discomfort of irritated tissues.*3
Double-blinded trials in patients with irritated sinuses show
that the natural inflammatory response is reduced more effectively by
concentrated bromelain than by placebo.*4 ,5 ,6 ,7
In all cases, a majority of people responded well to bromelain
has also helped reduce the duration of the natural inflammatory
response after nasal procedures by over 70% in a controlled trial.*8
recommended daily amount of Nature’s Life Sinus Ease™
utilizes 1,200 mg a very high potency bromelain enzyme which has
an activity of 2,880 GDU (Gelatin Digestive Units), or 4,320 MCU (Milk
Clotting Units) per serving.
C also helps reduce histamine release.*9
Some studies have reported that vitamin C is useful in reducing
the natural inflammatory response in nasal passages.*10, 11, 12
The effectiveness of vitamin C in reducing histamine release is
still debated, however, because a controlled trial was unable to show
consistent effects.*13 Doses up to 2 grams per day have been used
by researchers. It may be difficult to show these effects in research
trials because vitamin C appears to help only some people without
affecting others.*14 Studies, however, clearly show that vitamin C
supplementation can lower elevated blood levels of histamines.*15, 16
Nature’s Life adds naturally-buffered vitamin C to Sinus Ease due to
its safety, immune-supporting effects and potential efficacy to reduce
is a bioflavonoid found in many natural foods including citrus fruits,
onions, apples, tea and lettuce. As with bromelain, quercetin helps
reduce the natural inflammatory response by inhibiting the natural
formation of the pro-inflammatory agents, prostaglandins and
leukotrienes (white blood cells).*17,18
Quercetin also helps lessen the natural inflammatory response for
children with sensitivities to inhalants.*19
Additionally, quercetin may help reduce the effects of harmful
micro-organisms *20 Bioflavonoids
at doses of 1,200 mg per day have reduced the natural inflammatory
response in human studies in combination with 1,200 mg vitamin C,21 an
outcome confirmed in double-blinded research using 600 mg/day of
bioflavonoids and 450 mg/day of vitamin C.*22
which inhibit the natural inflammatory response rarely target just one
part of the body.* While quercetin has yet to be tested in reducing the
natural inflammatory response in sinuses specifically, doctors of
natural medicine frequently use it for that purpose because of its
proven ability to lessen the natural inflammatory response elsewhere in
Life Sinus Ease™
Life has combined these powerful phytonutrients to make Sinus Ease™.
High potency Bromelain, Quercetin and vitamin C work to inhibit the
natural pro-inflammatory response and encourage adequate sinus
drainage.* No safety concerns have been identified with any of these
ingredients.23, 24 It is recommended to take the three capsules per day between
meals. Since bromelain is a proteolytic enzyme, if taken with a meal it
will act on the protein in the food rather than the natural
pro-inflammatory fibrin, so remember to take it between meals.*
Enjoy the winter season and find relief from allergens throughout
the year! Nature’s Life
Sinus Ease™ can help.
Taussig SJ. The mechanism of the physiological
action of bromelain. Med
Martin GJ. Bromelain pineapple
proteases with anti-edema activity. Exper
Med Surg 1962;20:228-48.
Blonstein JL. Control of swelling in
boxing injuries. Practitioner
Seltzer AP. Adjunctive use of
bromelains in sinusitis: a controlled study. EENT
Taub SJ. The use of Ananase in
sinusitis—a study of 60 patients. EENT
Ryan RE. A double-blind clinical
evaluation of bromelains in the treatment of acute sinusitis. Headache 1967;7:13-7.
Taub SJ. The use of bromelains in
sinusitis: a double-blind clinical evaluation. EENT
Seltzer AP. Minimizing post-operative
edema and ecchymoses by the use of an oral enzyme preparation (bromelain).
Johnson CS, Martin LJ, Cai X.
Antihistamine effect of supplemental ascorbic acid and neutrophil
chemotaxis. J Am Coll Nutr
Zuskin E, Lewis AJ, Bouhuys A.
Inhibition of histamine-induced airways constriction by ascorbic
acid. J Allergy Clin Immunol
Ruskin SL. High dose vitamin C in
allergy. Am J Dig Dis
Holmes HN. Hay fever and vitamin C. Science
Fortner BR, Danziger RE, Rabinowitz
PS, Nelson HS. The effect of ascorbic acid on cutaneous and nasal
response to histamine and
allergen. J Allergy Clin
Bai TR, Martin JG. Effects of
indomethacin and ascorbic acid on histamine induced
bronchoconstriction in normal subjects.
Med J 1986;99:163 [abstr].
Holmes H, Alexander W. Hay Fever and
Vitamin C. Science
Johnston CS, Martin LJ, Xi C.
Antihistamine Effect of Supplemental Ascorbic Acid and Neutrophil
Chemotaxis. J Am Coll Nutr
Middleton E, Drzewieki G. Naturally
occurring flavonoids and human basophil histamine release. Arch Allergy Applied Immunol 1985;77:155-7.
Welton AF, Tobias LD, Fiedler-Nagy C,
et al. Effect of flavonoids on arachidonic acid metabolism. Prog Clin BiolRes 1986;213:231-42
Balabokin II, Gordeeva GF, Fuseva ED,
et al. Use of vitamins in allergic illnesses in children. Vopr Med Khim (Russia) 1992;38:36-40.
Ohnishi E, Bannai H. Quercetin
potentiates TNF-induced antiviral activity. Antiviral
Miller MJ. Injuries to athletes. Med
Cragin RB. The use of bioflavonoids
in the prevention and treatment of athletic injuries. Med Times 1962;529-32.
Taussig SJ, Yokoyama MM, Chinen N, et
al. Bromelain: A proteolytic enzyme and its clinical application. Hiroshima
J Med Sci 1975;24:185-193.
Hertog MGL, Feskens EJM, Holman
PCH, et al. Dietary flavonoids and cancer risk in the Zutphen
elderly study. Nutr Cancer 1994;22:175-84.