- *MSRP:
$15.99- Our Price:
- $9.28
- Buy: at $9.28
- UPC: 733739006103
- # N0610
NOW Foods Citrus Bioflavonoids 700 mg – 100 Veg Capsules (Item N0610)
NOW Foods Citrus Bioflavonoids 700 mg delivers concentrated plant antioxidants derived directly from the inner peels and pulp of whole sun-ripened citrus fruits, including lemons, limes, oranges, grapefruits, and tangerines. Formulated to reinforce your cardiovascular system, strengthen fragile capillary walls, and promote cellular defense against oxidative stress, this formula pairs an active citrus bioflavonoid complex with synergistic Vitamin C and natural rutin powder.
Each individual vegetarian capsule provides 700 mg of pure citrus bioflavonoid complex. A full 2-capsule daily serving provides 1,400 mg of bioflavonoids alongside 100 mg of Vitamin C (as Ascorbic Acid), supplying the exact botanical cofactors your body needs for maximum biological absorption and tissue retention.
- ✔ Vascular & Vein Integrity: Helps reinforce microscopic capillary walls, minimize easy bruising, and maintain normal venous elasticity.
- ✔ Synergistic Vitamin C Recycling: Extends the active life of Vitamin C inside cells by preventing rapid oxidation.
- ✔ Broad-Spectrum Free Radical Defense: Packed with natural flavanones including hesperidin, eriocitrin, naringin, and flavonols.
- ✔ Clean Plant-Based Formula: 100% vegan, Non-GMO Project Verified, Kosher certified, and free of gluten, soy, dairy, eggs, and nuts.
How Citrus Bioflavonoids Work in the Human Body
Bioflavonoids were historically discovered alongside Vitamin C in the 1930s by Nobel laureate Albert Szent-Györgyi, who originally termed them “Vitamin P” due to their ability to regulate microvascular permeability. Modern nutritional biochemistry shows that bioflavonoids and ascorbic acid work in tight biological coordination:
- The Vitamin C “Sparing” Effect: Vitamin C oxidizes rapidly when neutralizing free radicals. Bioflavonoids donate electrons to oxidized ascorbic acid (dehydroascorbic acid), recycling it back into its active antioxidant form. Landmark human bioavailability trials demonstrated that Vitamin C administered alongside a natural citrus bioflavonoid complex achieved significantly higher plasma concentrations and longer physiological retention than isolated ascorbic acid alone (Vinson & Bose, 1988; Carr & Frei, 1999).
- Microvascular Wall Protection: Capillaries are tiny blood vessels lined with delicate endothelial cells supported by collagen and elastin. Citrus bioflavonoids inhibit degrading enzymes—specifically hyaluronidase and elastase—while stimulating endothelial nitric oxide synthase (eNOS). This biological activity helps maintain capillary tone, reduces microvascular leakage, and promotes normal vascular resistance against physical bruising (Struckmann & Nicolaides, 1994; Rizza et al., 2011).
- Cellular Antioxidant & Nrf2 Pathway Activation: Flavanones such as hesperidin and naringin cross cell membranes to quench hydroxyl radicals and superoxide anions directly. Beyond direct radical scavenging, they stimulate the body’s internal master antioxidant switch (the Nrf2 pathway), upregulating your cells’ endogenous production of protective enzymes like superoxide dismutase (SOD) and glutathione peroxidase (Martinez-Castillo et al., 2018).
- Immune Signaling & Mast Cell Stability: Bioflavonoids modulate the release of inflammatory mediators and help stabilize cell membranes, attenuating excessive histamine release and promoting balanced immune responses during seasonal challenges (Formica & Regelson, 1995).
• Vinson, J. A., & Bose, P. (1988). Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract. The American Journal of Clinical Nutrition, 48(3), 601-604.
• Carr, A. C., & Frei, B. (1999). Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects. The American Journal of Clinical Nutrition, 69(6), 1086-1107.
• Struckmann, J. R., & Nicolaides, A. N. (1994). Flavonoids: A review of the pharmacology of micronized purified flavonoid fraction (MPFF) and its role in chronic venous insufficiency. Angiology, 45(6), 419-428.
• Rizza, S., et al. (2011). Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function. J. Clin. Endocrinol. Metab., 96(5), E782-E792.
• Formica, J. V., & Regelson, W. (1995). Review of the biology of Quercetin and related bioflavonoids. Food and Chemical Toxicology, 33(12), 1061-1080.
Supplement Facts & Complete Ingredients
NOW Foods standardizes each batch to ensure consistent active flavonoid levels. Below are the exact nutritional values and ingredients listed on the manufacturer product label:
| Supplement Facts | Serving Size: 2 Veg Capsules |
|---|---|
| Servings Per Container: 50 (100 Capsules per Bottle) | |
| Active Component | Amount Per Serving (% Daily Value) |
| Vitamin C (as Ascorbic Acid) | 100 mg (111% DV) |
| Citrus Bioflavonoid Complex (Delivers 700 mg of citrus bioflavonoid complex per single capsule; rich in active hesperidin, eriocitrin, naringin, and rutin) |
1.4 g (1,400 mg) (†) |
| † Daily Value (DV) not established. | |
Other Ingredients: Hypromellose (cellulose capsule), Stearic Acid (vegetable source), and Silicon Dioxide.
Allergen Specifications: Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut, or sesame ingredients. Produced in a certified GMP facility that processes other ingredients containing these allergens.
Product Identifiers: VitaNet SKU: N0610 | Manufacturer SKU: 0610 | Bottle UPC: 733739006103.
NOW Foods Lab Purity, Analytical Testing & Contaminant Limits
In an unregulated marketplace flooded with white-labeled and unverified supplements, NOW Foods operates one of the most sophisticated in-house dietary supplement testing infrastructures in the world. Operating out of over 100,000 square feet of state-of-the-art testing laboratories in Bloomingdale, Illinois, and Sparks, Nevada, NOW conducts over 19,000 analytical tests every month to guarantee raw material purity, potency, and safety:
- ISO/IEC 17025:2017 Laboratory Accreditation: NOW’s internal testing facilities are independently accredited by the American Association for Laboratory Accreditation (A2LA), the international gold standard for laboratory competence, calibration, and method validation.
- Heavy Metal Quantification via ICP-MS: Using Inductively Coupled Plasma Mass Spectrometry (ICP-MS), NOW tests every raw botanical lot for toxic heavy metals—Lead, Arsenic, Cadmium, and Mercury—detecting trace contaminants down to parts-per-billion (ppb) thresholds. NOW enforces contaminant constraints that easily surpass USP monograph standards and comply with California Proposition 65 limits.
- HPLC & UPLC Active Ingredient Verification: High-Performance Liquid Chromatography separates and quantifies individual flavonoid compounds (such as hesperidin and rutin) to verify that raw extracts meet exact label-claimed therapeutic potencies before encapsulation.
- Agricultural Residue & Pesticide Screening via GC-MS/MS: Gas Chromatography-Tandem Mass Spectrometry screens citrus raw materials for hundreds of common agricultural pesticides, fungicides, and chemical extraction solvents to ensure complete botanical cleanliness.
- Botanical Fingerprinting & Identity Testing: Utilizing High-Performance Thin-Layer Chromatography (HPTLC) and sensory analysis, raw powders are positively verified against authenticated botanical reference standards to prevent economic species adulteration or dilution.
- Comprehensive Microbiological Screening: Automated bio-burden testing screens all lots for pathogens, including Salmonella, Escherichia coli, Staphylococcus aureus, aerobic plate count, total yeast, and mold.
NOW facilities maintain Underwriters Laboratories (UL) GMP Certification, NPA A-rated Good Manufacturing Practice accreditation, and Intertek GMP verification, ensuring that the bottle of Citrus Bioflavonoids you receive matches its label without compromise.
Suggested Usage, Daily Dosage & Safety Precautions
To achieve optimal absorption and ongoing cellular support, use the following clinical usage guidelines:
- Suggested Daily Routine: Take 2 capsules daily, preferably with meals and a full 8 oz glass of water. If you prefer spaced dosing throughout the day, take 1 capsule (700 mg) with breakfast and 1 capsule (700 mg) with dinner.
- Synergistic Stacking: For targeted vascular, skin, or immune defense, combine Citrus Bioflavonoids with supplemental Vitamin C (such as NOW Vitamin C-1000 buffered complex) or Pycnogenol / French Maritime Pine Bark Extract to amplify collagen synthesis and microvascular blood flow.
- Storage Conditions: Store in a cool, dry, dark location away from direct sunlight, excess heat, and bathroom moisture. Keep bottle tightly closed with desiccant packet inside.
Real-World Precautions & Drug Interactions
- Blood-Thinning / Anticoagulant Medications: Rutin and bioflavonoids possess mild antiplatelet activity. If you take warfarin (Coumadin), clopidogrel (Plavix), or daily therapeutic aspirin, consult your prescribing physician prior to taking high-dose bioflavonoid supplements.
- CYP3A4 Enzyme Considerations: Because citrus bioflavonoid complexes contain polyphenols from grapefruits and Seville oranges (such as naringin), they can inhibit intestinal CYP3A4 enzymes responsible for clearing certain prescription medications (e.g., statins, calcium channel blockers, immunosuppressants). Check with your healthcare provider or pharmacist regarding potential citrus extract interactions.
- Scheduled Surgery: Discontinue supplementation at least 14 days prior to any planned surgical or dental procedure due to bioflavonoid effects on capillary circulation and clotting.
- Pregnancy & Nursing: For adult use only. If pregnant, nursing, or undergoing treatment for an existing medical condition, seek professional medical guidance before starting any dietary supplement.
Why Buy NOW Citrus Bioflavonoids From VitaNet®, LLC?
At VitaNet®, LLC, we understand that where you buy your supplements matters just as much as the brand you select. As an independent, family-owned health retailer founded in Ohio in 1995, we bring over 31 years of dedicated nutritional retail experience directly to your door[cite: 1]:
- 100% Risk-Free Money Back Guarantee: We stand behind every product we ship[cite: 1]. If you are unsatisfied for any reason, we offer an unconditional 100% money-back guarantee and we pay the return shipping costs—even on opened bottles[cite: 1].
- Direct-From-Manufacturer Inventory: Never risk expired, counterfeit, or commingled stock from unregulated third-party marketplace sellers. All VitaNet inventory is sourced directly through verified manufacturer channels and maintained in climate-controlled facilities.
- Brick-and-Mortar Heritage & BBB A+ Accreditation: We own and operate our physical retail location and distribution warehouse at 887 Edison Street NW, Hartville, Ohio 44632[cite: 1]. You are always backed by an established, verified American small business[cite: 1].
- Real Human Customer Support: Have questions about your order or product details? Speak directly with knowledgeable team members by calling our store at (330) 877-8786 during business hours[cite: 1].
Frequently Asked Questions (FAQ)
1. What are citrus bioflavonoids, and why are they paired with Vitamin C?
Citrus bioflavonoids are polyphenolic plant pigments extracted from citrus rinds that provide concentrated antioxidant defense. In nature, fruits never contain isolated ascorbic acid; they always package Vitamin C alongside rich bioflavonoids. When taken together, bioflavonoids protect Vitamin C from rapid oxidative breakdown, enhance its cellular uptake, and amplify its vascular and collagen-building benefits.
2. Does each capsule contain 700 mg or 1,400 mg?
Each individual veg capsule contains 700 mg of pure Citrus Bioflavonoid Complex. The manufacturer’s recommended daily serving size is 2 veg capsules, providing a total of 1,400 mg (1.4 g) of bioflavonoids plus 100 mg of Vitamin C. A 100-capsule bottle provides 50 full 2-capsule servings or 100 days of single-capsule maintenance.