Why does this formula include mixed tocopherols instead of just d-alpha tocopherol?

While d-alpha tocopherol is the primary form recognized and circulated by your liver's transport proteins, nature provides vitamin E as a balanced family of alpha, beta, delta, and gamma tocopherols. Research shows that gamma-tocopherol is especially potent at neutralizing reactive nitrogen species, a damaging type of cellular stress in blood vessels that alpha-tocopherol cannot stop on its own. Keeping all four tocopherols together mirrors whole foods and provides broad-spectrum antioxidant protection.

What is the difference between natural d-alpha and synthetic dl-alpha vitamin E?

“d-alpha” is the natural form extracted from plants. Your liver has a dedicated transport protein (a-TTP) that binds directly to this exact molecular shape. “dl-alpha” is a synthetic chemical compound manufactured from petroleum byproducts. Synthetic vitamin E contains eight different mirror-image molecules, but your body only efficiently uses one, making synthetic forms roughly 50% less bioavailable than natural d-alpha.

Can I pierce the softgel and apply the oil directly to my skin?

Yes. You can carefully snip the tip of the softgel with clean scissors and squeeze the golden oil directly onto cuticles, dry skin patches, or minor scars. Because the carrier base is organic extra virgin olive oil, it makes a soothing, natural topical moisturizer that delivers direct antioxidant hydration without artificial additives.

Will taking this softgel break an intermittent fast?

Yes, technically it will. The bovine gelatin shell and organic olive oil carrier contain trace calories (roughly 2 to 3 calories). More importantly, fat-soluble vitamins require dietary fats from a real meal to trigger digestive bile for proper absorption. For best results, take your softgel with your first solid meal when opening your eating window.

Is this product safe for people with soy sensitivities?

While the raw vitamin E is extracted from non-GMO soy, it undergoes rigorous molecular distillation and purification that completely removes allergenic soy proteins. However, because it is produced in a facility that handles diverse ingredients, anyone with a severe, life-threatening soy allergy should consult their physician before use.

E-400 MT - 100 SGELS

by NOW FOODS

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UPC: 733739008923: # N0892

NOW Foods Vitamin E-400 with Mixed Tocopherols (268 mg / 400 IU) – 100 Softgels

NOW Foods Vitamin E-400 delivers 268 mg (400 International Units) of 100% plant-derived natural d-alpha tocopherol enriched with a complete blend of natural mixed tocopherols (d-beta, d-delta, and d-gamma). Suspended in cold-pressed certified organic extra virgin olive oil, this daily fat-soluble formula enters your bloodstream smoothly to shield your cell walls against everyday oxidative stress. It provides broad antioxidant defense for your heart, blood vessels, immune system, and skin health without synthetic petroleum chemicals [1, 2].

Quick Specs Snapshot

✓ Active Form & Potency: 268 mg (400 IU) of pure natural d-alpha tocopherol per softgel (1,787% Daily Value), supported by natural d-beta, d-delta, and d-gamma mixed tocopherols.
✓ Primary Cellular Target: Cell membrane lipid bilayers, vascular walls, and circulating blood lipids, protecting delicate fats from free radical oxidation.
✓ Supply & Value Math: 100 easy-to-swallow softgels provide over 3 full months (100 days) of daily antioxidant protection for just pennies per day.
✓ Formulation Purity: Non-GMO plant source, BSE-free bovine gelatin, carried in pure organic extra virgin olive oil, and packaged in a 100% post-consumer recycled (PCR) resin bottle.

Buyer’s Guide: Natural vs. Synthetic Vitamin E

Why the Form Matters

The type of vitamin E you take makes a huge difference in how your body uses it. Cheap drugstore and big-box store brands frequently use synthetic vitamin E labeled as “dl-alpha tocopherol,” which is chemically manufactured from petroleum byproducts [1]. Synthetic vitamin E is a mixture of eight different mirror-image molecules, but your body can only properly use one of them [1]. Your liver makes a special escort protein called alpha-tocopherol transfer protein (α-TTP) that binds directly to natural d-alpha tocopherol like a key fitting into a lock [1, 3]. This gives natural plant-derived vitamin E twice the biological retention of synthetic options [1]. In addition, NOW includes natural mixed tocopherols (d-beta, d-delta, and d-gamma) to deliver the full spectrum of cellular protection found across whole plant foods [2].

Is This Formula Right for You?

Ideal For Shoppers Who:

✓ Want verified, plant-derived 400 IU (268 mg) natural vitamin E instead of cheap, petrochemical-derived synthetic formulas [1].
✓ Desire the broader cellular defense of natural mixed tocopherols (beta, delta, and gamma) working alongside d-alpha [2].
✓ Prefer a clean carrier base of certified organic extra virgin olive oil over oxidized corn or low-grade vegetable oils.

Consider Another Option If:

✗ You follow a strict vegan lifestyle (this softgel uses BSE-free bovine gelatin; consider dry vegetarian capsules instead).
✗ You take prescription blood-thinning medications and have not yet consulted your physician regarding a 400 IU daily dose.
✗ You have severe fat-malabsorption conditions or lack a gallbladder and require an oil-free, dry succinate powder formula.

Risk-Free Assurance from VitaNet®, LLC: Every purchase is backed by our unconditional 100% money-back guarantee—even on opened bottles, with return shipping covered by us—so you can evaluate digestive comfort and personal fit completely risk-free.

How It Works: Biochemical Pathways in Plain English

To understand how vitamin E protects your body, imagine your cells are like tiny houses. Every room is surrounded by an outer wall called a cell membrane, made mostly of delicate fatty layers. Normal breathing, physical exercise, sunlight, and everyday digestion create unstable molecules called free radicals (such as reactive oxygen species, O₂^•−). Think of free radicals like flying sparks from a campfire. When these sparks hit your cell membranes, they cause a damaging chain reaction called lipid peroxidation, which is just like cooking oil turning rancid or iron rusting [3].

Vitamin E (chemical formula C₂₉H₅₀O₂ for d-alpha tocopherol) is naturally fat-soluble. Because of its oily molecular structure, it travels straight into your cell membranes and embeds itself directly inside the fatty wall [3]. When an unstable free radical attacks, vitamin E acts like a cellular shield: it donates a hydrogen atom and an electron to extinguish the spark immediately [2, 3]. This stops the destructive chain reaction in its tracks before your cell wall can be damaged [3].

The Mixed Tocopherols Advantage

NOW elevates this formula by adding natural mixed tocopherols. While d-alpha tocopherol specializes in stopping oxygen free radicals, gamma-tocopherol (C₂₈H₄₈O₂) possesses a unique chemical shape that traps reactive nitrogen species (such as nitrogen dioxide, NO₂), an aggressive type of cellular stress found in blood vessels [2]. Suspended in organic extra virgin olive oil rich in oleic acid (C₁₈H₃₄O₂), these fat-soluble nutrients easily form microscopic droplets called micelles in your digestive tract, ensuring smooth absorption into your lymphatic system [4].

Daily Dosing, Timing, and Helpful Combinations

Optimal Timing & Meal Pairing

Take 1 softgel daily with a meal containing healthy dietary fats [4]. Because vitamin E is fat-soluble, your digestive system requires dietary lipids to trigger the gallbladder to release bile acids and the pancreas to release digestive enzymes [4]. These fluids create microscopic transport bubbles called micelles, which ferry the tocopherols across your intestinal wall and into your bloodstream [3, 4]. Taking vitamin E on an empty stomach drastically lowers absorption.

Daily Schedule & Habit Stacking

Because this formula provides 268 mg (400 IU) in a single softgel, you only need one per day. Take your softgel consistently with breakfast or lunch. Vitamin E builds up smoothly in cell walls and fatty tissues, providing stable 24-hour antioxidant defense throughout your waking hours [1].

Smart Synergies & Spacing Rules

✓ The Vitamin C Recharge Team: When vitamin E neutralizes a free radical spark, it temporarily loses an electron. Vitamin C (ascorbic acid, C₆H₈O₆) acts like a battery charger, donating an electron back to vitamin E so it can return to defending your cell walls [3].
✗ The 2-Hour Spacing Rule: Space your vitamin E softgel at least 2 hours away from inorganic iron supplements (such as ferrous sulfate) or fat-binding weight-loss products, which can bind together in your digestive tract and reduce absorption.

Timeline of Expectations

✓ Week 1 (Uptake & Circulation): The softgel dissolves cleanly; active tocopherols enter circulating blood lipoproteins to protect blood lipids from immediate oxidation [1, 4].
✓ Weeks 3–4 (Cellular Saturation): Continuous daily intake saturates deeper cell membranes, vascular walls, and skin tissue, building an active antioxidant reserve [1].
✓ Months 2–3+ (Long-Term Defense): Sustained tissue equilibrium supports arterial flexibility, skin hydration, and durable cellular defense against daily oxidative wear and tear [2, 3].

Capsule Details, Sensory Notes, and Clean Ingredients

Delivery Format & Swallowability

NOW Vitamin E-400 with Mixed Tocopherols comes in a smooth, oval bovine gelatin softgel. The slick outer surface glides down effortlessly with a standard sip of water, eliminating the chalky throat irritation and swallowing difficulty common with large tablets or dry capsules.

Natural Aroma, Taste & Color

When swallowed whole, the softgel is completely odorless and tasteless. Inside, the pure oil has a rich golden-amber appearance. Because NOW Foods uses pure plant extracts and organic extra virgin olive oil without artificial dyes or titanium dioxide, natural color variations from clear gold to darker amber are completely normal between harvest seasons.

Other Ingredients Demystified

✓ Bovine Gelatin (BSE-free): Certified safe, high-purity protein that creates the airtight capsule shell to protect the delicate oil from oxygen.
✓ Glycerin: A plant-derived moisture holder that keeps the softgel flexible so it will not crack or leak during storage.
✓ Water: Purified water used during the softgel encapsulation process.
✓ Organic Extra Virgin Olive Oil: Cold-pressed, unrefined Mediterranean olive oil rich in oleic acid (C₁₈H₃₄O₂) that keeps the fat-soluble vitamin dissolved for gentle, efficient absorption [4].
✓ Mixed Tocopherols (d-beta, d-delta, d-gamma): Natural botanical tocopherol fractions that shield active d-alpha tocopherol from oxidation while providing full-spectrum cell support [2].
✓ Non-GMO Highly Refined Soy Source: Extracted from non-GMO soy, but deeply purified through molecular distillation to remove soy proteins, meeting non-allergenic purity standards.

Storage & Eco-Friendly Packaging

Store your bottle tightly closed in a cool, dry place after opening. Keep it away from steamy bathrooms and sunny window sills. The bottle is molded from 100% post-consumer recycled (PCR) resin, protecting your supplements from UV light while keeping plastic waste out of our landfills and oceans.

Supplement Facts and NOW Quality Standards

Supplement Facts

Serving Size: 1 Softgel

Servings Per Container: 100

Description	Amount per Serving	% Daily Value
Vitamin E (as d-alpha Tocopherol)	268 mg	1787%

Other Ingredients: Softgel Capsule [bovine gelatin (BSE-free), glycerin, water], Organic Extra Virgin Olive Oil and Mixed Tocopherols (d-beta, d-delta, d-gamma).

Allergen Notice: Vitamin E from non-GMO soy (highly refined). Not manufactured with yeast, wheat, gluten, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Caution: For adults only. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children.

Natural color variations may occur in this product. Store in a cool, dry place after opening. Family and employee owned. Made and quality tested in the USA with globally sourced ingredients.

NOW Brand In-House Lab Testing & Contaminant Screening

Many discount supermarket and big-box store brands cut corners by buying generic bulk softgels from unverified overseas brokers, doing little more than checking a paper certificate before stocking shelves. In contrast, NOW operates industry-leading, ISO/IEC 17025 accredited in-house testing laboratories, performing over 19,000 analytical tests every single month to guarantee absolute safety, potency, and purity.

Curator’s Quality Assurance Note

Curated by the VitaNet®, LLC Nutritional Biochemistry Team. Founded in 1995 as an independent, family-owned health retailer in Hartville, Ohio, VitaNet®, LLC brings over 31 years of direct supplement curation and biochemical expertise to your doorstep. As a BBB A+ accredited retailer, we evaluate raw material sources and verify manufacturer lab testing so you never have to settle for questionable supermarket brands. Order with complete confidence knowing your purchase is backed by our unconditional 100% money-back guarantee—even on opened bottles, with return shipping covered.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.