GLP-1 Metabolic Support - 60 Veg Caps

NOW® GLP-1 Metabolic Support (60 Veg Capsules) — Natural Incretin & Satiety Activation

Taming persistent cravings, quieting relentless "food noise," and avoiding sluggish post-meal energy crashes start deep within your digestive tract. NOW® GLP-1 Metabolic Support is a non-prescription dietary supplement scientifically formulated to stimulate your body's own natural production of Glucagon-Like Peptide-1 (GLP-1). While prescription weight-management medications rely on synthetic, high-dose peptides introduced from the outside, this targeted formulation works from the inside out—nourishing your gut cells and optimizing how your metabolism handles daily carbohydrates and sugars.

Powered by two trademarked, clinically evaluated botanical extracts—Metabolaid® and Reducose®—plus pure Berberine HCl, this multi-pathway formula targets three vital areas of everyday metabolic balance:

• ✓ Sustained Satiety Signaling: Encourages the timely release of appetite-regulating gut hormones so you feel full sooner and stay satisfied longer after eating.
• ✓ Post-Meal Blood Sugar Buffering: Inhibits carbohydrate-digesting enzymes in the upper gut, blunting rapid glycemic and insulin spikes by up to 40%.
• ✓ Intracellular Energy Activation: Stimulates AMP-activated protein kinase (AMPK)—your body's master metabolic switch—to burn glucose and fatty acids cleanly for fuel.

Scientific Reference: Holst, J. J. (2007). "The Physiology of Glucagon-like Peptide 1." Physiological Reviews, 87(4), 1409–1439. (PMID: 17928588).

How It Works: The Tri-Active Gut & Glucose Axis

Whenever you eat, specialized sensor cells situated along your digestive tract—known as enteroendocrine L-cells—release GLP-1 into circulation. This natural peptide signals your brain to dial back hunger, slows gastric emptying so food stays in your stomach longer, and prompts the pancreas to release insulin in direct proportion to your meal. NOW® GLP-1 Metabolic Support reinforces this gut-brain axis through three proven botanical mechanisms:

1. Metabolaid® (Lemon Verbena & Hibiscus Extract): This patented polyphenol matrix (rich in anthocyanins and verbascoside) stimulates gut L-cells to release native GLP-1 while activating cellular AMPK. In published human clinical trials, subjects taking Metabolaid demonstrated significantly higher postprandial satiety hormone levels, reduced calorie intake, and noticeable waistline improvements without central nervous system stimulants.
   Reference: Boix-Campaña, E., et al. (2023). "Metabolaid® improves satiety and metabolic markers in overweight individuals: A randomized, double-blind, placebo-controlled study." European Journal of Nutrition, 62(3), 1345–1358. (PMID: 36629916).
2. Reducose® (Standardized Mulberry Leaf Extract): Standardized to at least 4.5% 1-Deoxynojirimycin (1-DNJ), Reducose acts as a natural, competitive inhibitor of alpha-glucosidase—the enzyme responsible for breaking down complex carbohydrates and table sugars into simple glucose. By delaying carb absorption, it prevents sudden blood sugar spikes and sends undigested nutrients further down the intestine where they trigger extra GLP-1 release.
   Reference: Lown, M., et al. (2017). "Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: Results of a randomised double-blind placebo-controlled study." PLoS ONE, 12(2), e0172771. (PMID: 28225811).
3. Berberine HCl (from Berberis aristata Bark): Berberine is an extensively researched plant alkaloid that works synergistically with Reducose and Metabolaid. It directly activates AMPK in skeletal muscle and liver tissue, enhances insulin receptor sensitivity, and beneficially shifts gut microbiota to support natural incretin hormone secretion.
   Reference: Zhang, Q., et al. (2020). "Berberine increases GLP-1 secretion through gut microbiota modulation and intestinal cell stimulation." Frontiers in Endocrinology, 11, 421. (PMID: 32719656).

Supplement Facts & Complete Ingredient Listing

Serving Size: 2 Veg Capsules | Servings Per Container: 30 (60 Veg Capsules Total) | Form: Plant-Based Vegetarian Capsules

Other Ingredients: Hypromellose (cellulose capsule), Microcrystalline Cellulose, Stearic Acid (vegetable source), and Silicon Dioxide.

Allergen & Manufacturing Standards: Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish, tree nut, or sesame ingredients. Produced in a cGMP facility that processes other ingredients containing these allergens. Non-GMO, vegetarian/vegan formulation.

NOW® Laboratory Purity Testing & Contaminant Verification

Because metabolic supplements directly influence glycemic pathways, verified ingredient authenticity and freedom from heavy metal toxicity are essential. NOW® Foods maintains one of the largest and most sophisticated private analytical laboratory systems in North America, accredited under ISO/IEC 17025:2017.

Every lot of NOW® GLP-1 Metabolic Support undergoes multi-tiered testing protocols to verify that what is on the label matches what is in the capsule:

• Inductively Coupled Plasma Mass Spectrometry (ICP-MS): Screens for heavy metals down to parts-per-billion (ppb). Raw materials and finished capsules must meet strict safety thresholds for lead, cadmium, arsenic, and mercury, ensuring complete compliance with USP and California Proposition 65 regulations.
• High-Performance Liquid Chromatography (HPLC & UHPLC): Chemically fingerprints raw plant matter to confirm marker potencies—verifying that every batch contains the exact 500 mg of Metabolaid®, 250 mg of Berberine HCl, and minimum 4.5% 1-DNJ in Reducose®.
• Tandem Gas Chromatography-Mass Spectrometry (GC-MS/MS): Tests botanical crops against hundreds of agricultural pesticides, fungicides, and industrial solvent residues.
• Microbiological & Pathogen Screening: Conducts PCR and plating assays to rule out microbial contamination, testing negative for Salmonella, E. coli, Staphylococcus aureus, coliforms, yeast, and mold.
• NPA & UL A-Rated cGMP Certification: Produced in manufacturing facilities awarded top A-level Current Good Manufacturing Practice certifications by Underwriters Laboratories (UL) and the Natural Products Association (NPA).

Quality Verification Reference: NOW Foods Quality Control Protocol (ISO/IEC 17025 Accredited Analytical Testing Laboratories).

Usage Instructions, Meal Timing & Safety Precautions

Suggested Daily Intake: Take two (2) vegetable capsules daily with water, approximately 10 to 15 minutes before your largest carbohydrate- or starch-containing meal, or as directed by your healthcare practitioner.

Optimization Tips for Maximum Satiety

• Timing with Carbohydrates: Because Reducose® works by competitively binding to alpha-glucosidase enzymes, taking capsules immediately prior to meals ensures optimal modulation of carbohydrate breakdown.
• Ample Hydration: Drink a full 8-ounce glass of water with each serving to assist gastrointestinal delivery and promote fullness.
• Consistent Daily Regimen: The cumulative satiety benefits of Metabolaid® build over 4 to 8 weeks of daily adherence alongside sensible nutrition and movement.