Advanced Non-Hormonal DHEA Metabolite for Thermogenic Weight Management & Cellular Energy
7-Keto is a naturally occurring metabolite of DHEA (dehydroepiandrosterone), providing the metabolic benefits of DHEA without its associated hormonal side effects. Because the body's natural production of DHEA peaks around age 25 and steadily declines as we age, natural production of 7-Keto drops right along with it. Weight gain, sluggish metabolism, and a feeling of running on low energy are common signs of aging that frequently follow this drop.
Unlike ordinary weight management supplements that rely on high amounts of caffeine or nervous-system stimulants, patented 7-KETO® (DHEA Acetate-7-one) has been clinically studied and patented for its unique ability to safely support thermogenesis (cellular calorie burning) and assist in the long-term maintenance of healthy body weight.
Key Product Highlights:
✓Clinically Backed Dosing: 100 mg of genuine 7-KETO® per vegetarian capsule to easily reach the 200 mg daily clinical target.
✓100% Non-Hormonal: Does not convert into estrogen, testosterone, or androgens in the bloodstream.
✓Zero Jitters or Crashes: Stimulates calorie-burning enzymes naturally without stressing your adrenal glands or heart rate.
✓Clean Vegetarian Formula: Free from gluten, dairy, soy, yeast, corn, egg, and artificial preservatives.
How 7-Keto Works: Turning Up Your Cellular Metabolic Thermostat
Whenever you reduce calories to lose weight, your body naturally tries to defend its fat stores by slowing down your metabolic rate. You feel colder, your energy dips, and weight loss plateaus. 7-Keto helps counteract this biological slowdown through a process called thermogenesis—the process of cellular heat generation.
Inside your liver and muscle cells, 7-Keto signals your mitochondria (the microscopic power plants of your cells) to ramp up three vital calorie-burning enzymes:
Mitochondrial sn-Glycerol-3-Phosphate Dehydrogenase (GPDH): Directs fuel substrate cycles into energy release instead of fat storage.
Cytosolic Malic Enzyme: A master metabolic enzyme that accelerates the conversion of stored carbohydrates and fats into usable cellular fuel.
Fatty Acyl-CoA Oxidase: The initial rate-limiting enzyme in the breakdown of fatty acids via cellular beta-oxidation.
By encouraging these enzymes to run more actively, your body safely burns more calories as pure thermal energy rather than locking them away in adipose (fat) tissue, even when resting.
The Clinical Evidence: Real Human Studies on 7-KETO®
Unlike many trendy diet ingredients that rely on animal trials alone, 7-KETO® has undergone rigorous double-blind, randomized, placebo-controlled clinical trials in human subjects:
1. Double the Fat Loss in Overweight Adults
In an 8-week double-blind, placebo-controlled clinical study, researchers evaluated 30 healthy overweight adults on a calorie-restricted diet and exercise program. The group receiving 100 mg of 7-KETO twice daily (200 mg total) lost an average of 6.34 lbs (2.88 kg) and reduced body fat by 1.8%, compared to just 2.13 lbs (0.97 kg) and 0.57% fat lost in the placebo group.
Citation: Kalman, D. S., Colker, C. M., Shi, Q., & Swain, M. A. (2000). A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Current Therapeutic Research, 61(7), 435–442.
2. Preventing Diet-Induced Metabolic Slowdown
In another randomized clinical trial, participants consuming a reduced-calorie diet who supplemented with 7-KETO maintained and elevated their Resting Metabolic Rate (RMR) by an average of 1.4% to 5.4% above baseline, while the placebo group suffered a significant drop in daily metabolic output. Furthermore, 7-Keto safely supported active circulating T3 (thyroid hormone) levels without altering T4 or TSH.
Citation: Zenk, J. L., Helmerix, T. R., Kassen, N. R., & Kuskowski, M. A. (2002). The effect of 7-Keto Naturalean™ on weight loss: A randomized, double-blind, placebo-controlled study. Current Therapeutic Research, 63(4), 263–272.
3. Safety and Non-Hormonal Confirmation
A clinical safety study examining escalating oral doses in healthy human volunteers confirmed that 7-KETO does not convert into testosterone or estrogens and does not affect vital signs, liver enzymes, kidney biomarkers, or blood glucose levels.
Citation: Davidson, M. H., et al. (2000). Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clinical and Investigative Medicine, 23(5), 300–310.
7-KETO vs. Regular DHEA: Critical Differences Explained
Many people ask whether they can simply take standard DHEA instead of 7-Keto. While they sound similar, their behavior inside your body is fundamentally different:
Attribute
NOW® 7-KETO (100 mg)
Standard DHEA
Hormone Conversion
✓ Zero conversion to estrogen or testosterone
Converts readily into male & female sex hormones
Hormonal Side Effects
✓ No risk of acne, facial hair, mood swings, or hair loss
May trigger hormonal acne, mood changes, or hair thinning
Not manufactured with ingredients containing yeast, wheat, gluten, soy, milk, egg, fish, shellfish, or tree nuts. Produced in a GMP facility that processes other ingredients containing these allergens.
Formulation: Non-GMO, Vegetarian, and Vegan formulation.
Suggested Use, Dosing & Safety Guidelines
Suggested Use:
As a dietary supplement, take 1 Veg Capsule 2 times daily, preferably with meals. For maximum results, take one capsule with breakfast and one capsule with lunch or your midday meal.
Best Practices for Maximum Results:
Consistency Matters: In clinical studies, significant improvements in lean body mass and resting metabolic rate were observed over an 8-week cycle.
Pair with Activity: 7-Keto works best when combined with regular physical exercise (such as resistance training or brisk walking) and sensible nutrition.
Hydrate Well: Because thermogenesis gently increases cellular heat dissipation, ensure you drink plenty of water throughout the day.
Cautions & Warnings:
For adults only. Consult your healthcare provider prior to use if you are pregnant, nursing, taking prescription medications, or managing a medical condition. Keep out of reach of children. Store in a cool, dry place after opening.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Frequently Asked Questions (FAQ)
What is 7-KETO 100 mg and how does it differ from regular DHEA?
7-KETO (7-oxo-DHEA) is a natural downstream byproduct of DHEA. While parent DHEA can convert into steroid hormones like estrogen and testosterone in the body, 7-KETO is completely non-hormonal. It supports metabolic rate and cellular thermogenesis without impacting androgen or estrogen levels.
Does NOW 7-KETO 100 mg contain caffeine or cause jitters?
No. 7-KETO is completely stimulant-free. Unlike caffeine, synephrine, or green coffee bean extracts, 7-KETO does not stimulate your central nervous system, raise your pulse, or disrupt sleep when taken as directed.
How long does it take to see results with 7-KETO 100 mg?
In peer-reviewed human trials, measurable increases in resting metabolic rate were documented within 1 to 2 weeks, while statistically significant reductions in body fat and overall body weight were established across an 8-week period when paired with sensible eating and light-to-moderate exercise.
Can both men and women safely take 7-KETO 100 mg?
Yes. Because 7-KETO does not aromatize into estrogen or convert into testosterone, both men and women can safely use it without concerns about hormone-driven side effects like facial hair growth, voice deepening, or gynecomastia.
Does 7-KETO affect thyroid hormones or blood tests?
Clinical studies have demonstrated that 7-KETO helps maintain active T3 levels during dieting without altering T4 or Thyroid Stimulating Hormone (TSH). It does not shut down natural thyroid production. However, individuals taking prescription thyroid hormone medication should consult their physician before supplementing.
Can competitive athletes take 7-KETO?
Athletes competing under WADA (World Anti-Doping Agency) or NCAA rules should note that 7-KETO-DHEA is included on the prohibited substances list for tested competitive sports because its chemical signature is related to adrenal steroids. Non-tested athletes and fitness enthusiasts can use it without issue.
