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- UPC: 733739030160
- # N3016
NOW® CELADRIN® And MSM: Advanced Cellular Joint Lubrication & Mobility Support
Healthy movement requires more than just rebuilding worn cartilage; it demands continuous, friction-free joint lubrication. NOW® Foods CELADRIN® And MSM combines two clinically investigated compounds designed to support fluid joint motion from within: a high-potency 1,500 mg complex of patented Celadrin® esterified fatty acid carbons (EFAC) and 300 mg of pure Methylsulfonylmethane (MSM) per 3-capsule serving.
If conventional joint formulas like glucosamine and chondroitin have left you dealing with ongoing stiffness, this dual-action blend works through an entirely different biological pathway. Instead of relying on sugar-protein complexes, Celadrin reinforces the delicate lipid membrane of your joint cells, replenishing synovial fluid cushion, while MSM delivers biological sulfur to stabilize connective tissue structure.
- ✓1,500 mg Patented Celadrin®: Provides a targeted matrix of cetylated fatty acid carbons to cushion joint tissues and support smooth mobility.
- ✓300 mg Bioavailable MSM: Supplies active organic sulfur necessary for collagen formation, ligament elasticity, and cartilage integrity.
- ✓Glucosamine & Shellfish-Free: An ideal alternative for individuals with crustacean allergies or those sensitive to standard joint supplements.
- ✓Comprehensive Third-Party Lab Testing: Verified for identity, purity, and potency using ISO/IEC 17025 accredited analytical standards.
Mechanism of Action: How Celadrin® and MSM Restore Joint Comfort
To understand how CELADRIN® And MSM works, think of your joints as biological shock absorbers. Every joint is surrounded by a protective capsule lined with synovial fluid—a natural lubricant that prevents bone ends from grinding against each other. Age, repetitive physical training, and joint wear cause the lipid membranes of synovial cells to thin and stiffen. This leaves joint tissues vulnerable to friction, mechanical stress, and localized inflammatory cascades.
1. Celadrin® (Esterified Fatty Acid Carbons): Cellular Lubrication & Fluid Protection
Celadrin® is a specialized matrix of esterified fatty acid carbons (specifically cetyl myristate, cetyl myristoleate, cetyl oleate, cetyl palmitoleate, cetyl palmitate, and cetyl laurate). In simple terms, esterification binds these beneficial fatty acids so they do not break down rapidly during digestion. Once absorbed into the bloodstream, these functional lipids integrate directly into the phospholipid bilayers of your joint cell membranes.
By enhancing cell membrane fluidity and elasticity, Celadrin helps joint cells maintain hydration and preserve synovial fluid volume. In peer-reviewed clinical research published in The Journal of Rheumatology, oral administration of cetylated fatty acids produced statistically significant improvements in knee flexion, extension, and functional movement tests compared to placebo (Hesslink et al., 2002). Further laboratory evaluations published in the journal Cartilage confirmed that esterified fatty acid mixtures reduce the expression of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), helping shield chondrocytes (cartilage cells) from oxidative breakdown (Hudita et al., 2020).
2. MSM (Methylsulfonylmethane): Structural Connective Tissue Support
While Celadrin acts as the biological lubricant, MSM functions as structural reinforcement. MSM is an organic, bioavailable form of dietary sulfur. Sulfur is the third most abundant mineral in the human body and is critically concentrated in joints, tendons, and cartilage. It forms disulfide bonds—the molecular cross-links that give cartilage and collagen fibers their structural resilience, bounce, and tensile strength.
In a randomized, double-blind, placebo-controlled trial published in Osteoarthritis and Cartilage, daily MSM supplementation significantly decreased joint discomfort scores and produced meaningful improvements in the Western Ontario and McMaster Universities (WOMAC) physical function inventory (Kim et al., 2006). By combining cellular lubrication with collagen-building sulfur, NOW® Celadrin & MSM addresses both mobility and structural stability in one cohesive formula.
Complete Supplement Facts & Ingredient Listing
VitaNet® believes in full transparency. Every ingredient in NOW® Foods CELADRIN® And MSM is clearly accounted for, with zero proprietary filler masks or unlisted carriers.
Supplement Facts
Serving Size: 3 Capsules • Servings Per Container: 40 (120 Capsules)
| Amount Per Serving | % Daily Value |
|---|---|
| Calories | 15 |
| Total Fat | 1 g (1%*) |
| Total Carbohydrate | 1 g (<1%*) |
|
Celadrin® (A proprietary blend of esterified fatty acid carbons of Myristate, Myristoleate, Laurate, Oleate, Palmitate, and Palmitoleate) |
1.5 g (1,500 mg)† |
| MSM (Methylsulfonylmethane) | 300 mg† |
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established.
Other Ingredients: Gelatin (bovine capsule), Sodium Copper Chlorophyllin (natural plant chlorophyll for light protection), Magnesium Stearate (vegetable source), Silica.
Allergen & Dietary Information: Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients. Produced in a Good Manufacturing Practices (GMP) facility that processes other ingredients containing these allergens. Soy-free, nut-free, and non-GMO.
NOW® Brand Lab Testing & Contaminant Verification
When purchasing dietary supplements for joint care, ingredient purity is just as critical as active dosage. Fatty acid compounds and mined sulfur materials can easily be adulterated or tainted by environmental contaminants if manufacturing oversight is inadequate. NOW® operates one of the most advanced, privately owned nutritional analysis laboratories in the United States, subjecting every batch of CELADRIN® And MSM to strict analytical validation.
- ✓ISO/IEC 17025:2017 Lab Accreditation: NOW’s internal testing laboratories in Bloomingdale, Illinois, are formally accredited by the American Association for Laboratory Accreditation (A2LA Certificates 6253.01 for Chemical testing and 6253.02 for Biological testing), guaranteeing gold-standard scientific precision and calibration.
- ✓ICP-MS Heavy Metal Screening: Utilizing Inductively Coupled Plasma Mass Spectrometry (ICP-MS), every raw material lot is screened for toxic heavy metals—including Lead, Arsenic, Cadmium, and Mercury—at ultra-trace parts-per-billion (ppb) detection limits, strictly complying with California Proposition 65 and USP standards.
- ✓Gas Chromatography (GC-MS) Lipid Fingerprinting: Because Celadrin relies on a precise balance of esterified fatty acid carbons, NOW utilizes Gas Chromatography coupled with Mass Spectrometry to verify that every capsule matches the authentic molecular fingerprint of patented Celadrin®.
- ✓Microbiological & Allergen Assays: Batches undergo rigorous bio-burden analysis to ensure total absence of pathogens, including Salmonella spp., Escherichia coli, Staphylococcus aureus, mold, and environmental yeasts.
- ✓Over 19,000 Tests Monthly: NOW runs more than 19,000 analytical determinations every single month across its product lines, backed by NPA A-rated Good Manufacturing Practices (GMP) certification.