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- UPC: 733739046260
- # N4626
NOW Foods Celery Seed Extract (with Horse Chestnut & Hawthorn) – 60 Veg Capsules
Healthy circulation depends on flexible arteries, resilient capillary walls, and smooth fluid balance. When blood vessels stiffen or retain excess fluid, the cardiovascular system works harder, leading to heavy legs, fluctuating blood pressure, and sluggish circulation. At the same time, metabolic waste like uric acid can accumulate in the bloodstream and settle into joint tissues, triggering stiffness and localized discomfort.
NOW® Celery Seed Extract (Item #4626) is a targeted cardiovascular and metabolic support formula designed to tackle these challenges from three synergistic angles. Rather than offering basic celery powder, this clinical-grade botanical complex combines concentrated Celery Seed Oil Extract Powder with standardized Horse Chestnut Extract and Hawthorn Extract. Together, these botanicals help relax vascular smooth muscle, protect fragile capillaries against leakage, promote healthy venous return in the legs, and support kidney clearance of excess fluid and metabolic byproducts.
- Vascular Elasticity & Blood Pressure Support: Bioactive phthalides (such as 3nB) help smooth muscles in arterial walls relax naturally, encouraging normal blood pressure already within a healthy range.
- Venous Tone & Capillary Strength: Standardized horse chestnut (minimum 20% aescin) strengthens microvascular walls to reduce fluid buildup and leg heaviness.
- Metabolic Uric Acid Cleansing: Celery phytochemicals support the kidneys in filtering and expelling crystalline waste, maintaining joint comfort and tissue ease.
- Cardiovascular Antioxidant Defense: Hawthorn leaf and flower extract (standardized to 1.8% vitexin-2″-O-rhamnoside) supports coronary blood flow and protects endothelial tissues against oxidative wear.
How It Works: The Science of 3nB, Aescin & Hawthorn Bioflavonoids
Unlike simple single-herb remedies, NOW's botanical complex relies on three distinct, clinically studied active compounds that work along complementary physiological pathways:
1. Celery Seed Extract (Apium graveolens) and 3-n-Butylphthalide (3nB)
The distinctive scent and active properties of celery seed come from naturally occurring oily compounds known as phthalides, most notably 3-n-butylphthalide (3nB). In cardiovascular physiology, arterial tension is regulated by the contraction of smooth muscle cells surrounding your blood vessels. 3nB acts as a natural, mild calcium channel modulator: by regulating the flow of calcium ions into vascular smooth muscle, it encourages constricted arteries to relax and widen (vasodilation). This decreases overall peripheral resistance, enabling the heart to pump blood throughout the body with less effort.
Simultaneously, 3nB exerts a gentle aquaretic effect—facilitating healthy fluid excretion through the kidneys without disrupting essential potassium and electrolyte balances. In joint physiology, celery seed extract inhibits the enzyme xanthine oxidase, which is responsible for synthesizing uric acid, thereby helping to keep serum uric acid levels balanced and easing joint stiffness.
2. Horse Chestnut Extract (Aesculus hippocastanum) & Standardized Aescin
The lower extremities face constant gravitational pressure. When vein walls and micro-valves lose elasticity, fluid leaks through microscopic pores in the capillary beds into surrounding tissues, resulting in swollen ankles and fatigued legs. NOW provides 200 mg of Horse Chestnut standardized to a minimum of 20% Aescin, a potent triterpene saponin. Aescin reduces vascular permeability by sealing tiny capillary gaps and inhibiting lysosomal enzymes (such as hyaluronidase and elastase) that degrade the vascular collagen matrix. This restores healthy venous tone and improves blood return back up to the heart.
3. Hawthorn Extract (Crataegus oxyacantha / monogyna) & Vitexin
Hawthorn leaves and flowers supply oligomeric proanthocyanidins (OPCs) and flavone glycosides, specifically standardized to 1.8% Vitexin-2″-O-rhamnoside. Hawthorn enhances myocardial blood supply by dilating the coronary arteries and protecting vascular endothelial cells from lipid peroxidation and oxidative stress. This supports efficient cardiac output and complements the vascular-relaxing actions of celery seed.
Key Authoritative Clinical & Pharmacological References:
- Celery Seed & Blood Pressure: Shayani Rad, M., et al. (2022). Effect of celery (Apium graveolens) seed extract on hypertension: A randomized, triple-blind, placebo-controlled, cross-over clinical trial. Phytotherapy Research, 36(7), 2889–2907. DOI: 10.1002/ptr.7469.
- 3nB Mechanism & Vasorelaxation: Moghadam, M. H., et al. (2013). Antihypertensive effect of celery seed on rat blood pressure in chronic administration. Journal of Medicinal Food, 16(6), 558–563. DOI: 10.1089/jmf.2012.2533.
- Uric Acid Metabolism & Joint Protection: Li, S., et al. (2019). Anti-gouty arthritis and anti-hyperuricemia properties of celery seed extracts in rodent models. Molecular Medicine Reports, 20(5), 4623–4633. DOI: 10.3892/mmr.2019.10703.
- Horse Chestnut & Venous Tone: Pittler, M. H., & Ernst, E. (2012). Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database of Systematic Reviews, 2012(11), CD003230. DOI: 10.1002/14651858.CD003230.pub4.
- Hawthorn Cardiovascular Protection: Pittler, M. H., Guo, R., & Ernst, E. (2008). Hawthorn extract for treating chronic heart failure. Cochrane Database of Systematic Reviews, 2008(1), CD005312. DOI: 10.1002/14651858.CD005312.pub2.
Supplement Facts & Complete Ingredient Profile
NOW Foods publishes transparent, precise quantitative disclosures for every active marker. All ingredients are confirmed directly against official manufacturer specifications:
| Component / Serving Details | Amount Per Serving | % Daily Value |
|---|---|---|
| Serving Size | 1 Veg Capsule | |
| Servings Per Container | 60 Servings | |
| Celery Seed Oil Extract Powder (Apium graveolens) |
100 mg | * |
| Horse Chestnut Extract (Aesculus hippocastanum) (Seed/Fruit) (Standardized to min. 20% Aescin) |
200 mg | * |
| Hawthorn Extract [Hawthorn Extract (Leaf & Flower), Maltodextrin] (Standardized to min. 1.8% Vitexin-2″-O-rhamnoside) |
25 mg | * |
* Daily Value (DV) not established.
Other Ingredients: Microcrystalline Cellulose, Hypromellose (cellulose capsule), Stearic Acid (vegetable source), and Silicon Dioxide.
Allergen Declaration: Contains tree nut (horse chestnut).
Allergen Free From: ✓ Gluten-Free | ✓ Dairy-Free | ✓ Soy-Free | ✓ Egg-Free | ✓ Non-GMO | ✓ Vegan / Vegetarian | ✓ Kosher (Triangle K). Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish, or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
NOW Foods Rigorous Lab Testing & Contaminant Screening
Botanical extracts require strict quality controls. Because plants naturally take up minerals from soil and water, raw botanical powders can easily harbor heavy metals, pesticide residues, microbial pathogens, or synthetic adulterants if not screened rigorously. NOW Foods operates one of the most advanced private analytical testing programs in the nutritional supplement industry to verify purity and potency.
- ISO/IEC 17025 Accredited In-House Laboratories: NOW's internal testing facilities maintain ISO/IEC 17025 accreditation, the international gold standard for laboratory competence and calibration accuracy. Every production lot undergoes physical, chemical, and microbiological screening.
-
Heavy Metal Analysis via ICP-MS: Using Inductively Coupled Plasma Mass Spectrometry (ICP-MS), raw materials and finished capsules are tested down to parts-per-billion (ppb) concentrations for heavy metals, ensuring strict compliance with California Proposition 65 ceilings:
✓ Lead (Pb): Controlled far below regulatory limits
✓ Arsenic (As) (Inorganic): Fully screened and verified safe
✓ Cadmium (Cd) & Mercury (Hg): Thoroughly screened to eliminate environmental contamination - Botanical Identity & Active Marker Potency: High-Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC-MS) verify that every capsule delivers authentic Apium graveolens with intact 3nB phthalides, a minimum of 20% aescin from horse chestnut, and 1.8% vitexin from hawthorn. High-Performance Thin-Layer Chromatography (HPTLC) confirms the fingerprint identity against species adulteration.
- Microbiological Purity: In accordance with USP <2021> and <2022> standards, each batch is tested for total aerobic microbial count, yeast, mold, and verified 100% negative for harmful pathogens including Escherichia coli and Salmonella species.
- Clean Formulation Standards: Manufactured in an Intertek-certified cGMP facility. The formula contains no artificial colors, synthetic binders, hydrogenated oils, parabens, or irradiation treatments, and is packaged in bottles made from 100% post-consumer recycled (PCR) resin.
Practical Usage, Daily Dosage & Safety Precautions
To achieve optimal results from NOW Celery Seed Extract, consistency and proper hydration are key:
Recommended Dosage & Timing
Suggested Usage: Take 1 veg capsule twice daily, preferably with morning and evening meals, accompanied by an 8-ounce glass of water. Taking this extract with food supports smooth absorption of botanical bioflavonoids and minimizes minor stomach sensitivity.
Expected Onset: While mild fluid-balancing effects may be noticed within 48 to 72 hours, vascular tone and joint comfort benefits are cumulative. Clinical trials on celery seed extract and aescin show that the most meaningful improvements in circulatory health and uric acid balance occur after 4 to 8 weeks of daily use.
Precautions & Medical Contraindications
- Pregnancy & Nursing: For adults only. Do not use if you are pregnant, planning to become pregnant, or nursing. Celery seed compounds can stimulate uterine contractions.
- Known Plant Allergies: Do not use if you have known allergies to celery, horse chestnut, or plants in the Umbelliferae (Apiaceae) botanical family (including carrot, parsley, dill, fennel, and anise). Note that this product is labeled as containing tree nut due to horse chestnut classification.
- Kidney Disease: Persons with acute kidney inflammation, renal failure, or impaired renal function should avoid celery seed supplements. The natural diuretic actions increase renal filtration demands and may irritate sensitive renal tissues.
- Blood Thinning Medications: Celery seed and horse chestnut contain natural antiplatelet compounds. If you take anticoagulant or antiplatelet drugs (such as warfarin, clopidogrel, or daily aspirin), consult your prescribing physician before using this formula.
- Blood Pressure & Heart Medications: Because celery seed and hawthorn support vasodilation, they may produce additive effects when combined with prescription antihypertensive medications (such as ACE inhibitors or beta-blockers) or cardiac glycosides (such as digoxin). Routine blood pressure monitoring is recommended.
- Surgery: Discontinue supplementation at least 2 weeks prior to any elective surgery or dental procedure to minimize bleeding risks.
Why Choose VitaNet® for Your Supplement Needs?
Where you purchase your nutritional supplements matters just as much as the brand you choose. Mass online open marketplaces are filled with unverified third-party sellers, heat-damaged inventory, and questionable counterfeit products. VitaNet®, LLC is an independent, family-owned discount vitamin and herb retailer serving customers online since 1995.
✓ 31+ Years of Trusted Industry Experience: Founded in 1995 with physical store roots in Hartville, Ohio, our team evaluates product formulas with a deep understanding of nutritional biochemistry, bioavailability, and label accuracy.
✓ 100% Guaranteed Freshness & Climate-Controlled Storage: Botanical volatile oils, such as 3nB phthalides, degrade when exposed to heat and moisture. Our entire inventory is stored in climate-controlled facilities and sourced fresh through direct authorized manufacturer distribution channels.
✓ Unconditional 100% Money-Back Guarantee: We stand behind every bottle we ship. If you are not completely satisfied with your purchase, we refund your money and even cover return shipping costs—even on opened bottles.
✓ BBB A+ Accredited Independent Business: Real customer support by phone and email from an independent, family-operated American small business dedicated to honest everyday discount pricing.
Frequently Asked Questions (FAQ)
What are the primary benefits of celery seed extract?
Celery seed extract delivers bioactive phthalides, primarily 3-n-butylphthalide (3nB), which help relax vascular smooth muscle, support healthy circulation, and encourage blood pressure levels already within a normal range. It also promotes comfortable fluid balance through mild aquaretic action and assists the kidneys in clearing uric acid, supporting joint mobility and tissue comfort.