UPC: 097467047587
# NP4758

Natures Plus Kalm-Assure® Tablets (Product No. 4758 / # NP4758) – 60 Bi-Layered Tablets

KALM-ASSURE 60 by Natures Plus delivers targeted nutritional support for daily tension, mental clarity, and nervous system equilibrium. Formulated with an advanced, dual-phase delivery system, Kalm-Assure bridges the gap between fast-acting relief and long-lasting adaptogenic stability without causing daytime drowsiness or sluggishness.


Advanced Bi-Layered Technology: Immediate Calm & Sustained Equilibrium

Conventional stress supplements often present a trade-off: fast-absorbing capsules wear off quickly, while standard time-release tablets take too long to provide initial comfort. Kalm-Assure® Tablets utilize scientifically engineered bi-layered technology to deliver both rapid and sustainable results in a single, convenient dose:
  • The Rapid Release Layer: Promptly dissolves to deliver activated pantothenic acid (Vitamin B5) and bioavailable GABA (gamma-aminobutyric acid). This fast-acting phase quickly supports neurotransmitter balance and nourishes adrenal pathways during acute stress triggers.
  • The Sustained Release Layer: Utilizes an innovative micro-gel erosion matrix to steadily release a specialized combination of standardized botanicals—including passionflower, hops, chamomile, and eleuthero—alongside synergistic magnesium citrate and activated pyridoxal-5-phosphate (P-5-P) for steady, multi-hour relaxation.

Standardized Phytotherapy & Coenzymatic Synergy

Kalm-Assure is not a generic herbal blend. Every tablet supplies clinically studied botanicals standardized to exact active constituent levels, backed by coenzyme micronutrients essential for central nervous system function:

Inhibitory Neurotransmitter Support: GABA & P-5-P

GABA serves as the central nervous system's primary inhibitory neurotransmitter, buffering excessive excitatory neurological firing. To ensure optimal cellular utilization, this formula includes Pyridoxal-5-Phosphate (P-5-P)—the metabolically active coenzyme form of Vitamin B6. P-5-P acts as an obligatory catalytic cofactor for the enzyme glutamic acid decarboxylase (GAD), which synthesizes endogenous GABA, bypassing conversion inefficiencies common with standard pyridoxine HCl.

Targeted Botanical Standardization

The sustained release phase features premium herbal extracts verified for active marker compounds:
  • Passionflower (Passiflora incarnata) (Standardized 3.5%–4% [2.6–3 mg] Vitexins/Isovitexins): Phytochemically linked to positive modulation of central GABA receptors, helping soothe restless mental tension.
  • Chamomile (Matricaria recutita) (Standardized 1% [0.25 mg] Apigenin): Supplies apigenin, a natural flavonoid that binds specifically to benzodiazepine sites on GABA-A receptors to encourage neurochemical calm without cognitive fog.
  • Hops (Humulus lupulus) (Standardized 5.2% [0.52 mg] Bitter Acids): Works synergistically with passionflower and chamomile to relax smooth muscle fibers and quiet peripheral somatic tension.
  • Eleuthero Root (Eleutherococcus senticosus) (Standardized 0.8% [0.2 mg] Eleutherosides): A revered adaptogen that helps balance the hypothalamic-pituitary-adrenal (HPA) axis, modulating cortisol output during sustained physical or mental strain.

Adrenal & Neuromuscular Foundations

Each serving provides 50 mg of Pantothenic Acid (as calcium pantothenate), a vital precursor to Coenzyme A (CoA) required for steroid hormone production and adrenal cellular recovery, alongside bioavailable Magnesium (as citrate) to facilitate neuromuscular relaxation and intracellular ATP transport.

Complete Supplement Facts & Ingredient Listing

Serving Size: 1 Tablet | Servings Per Container: 60
Ingredient Amount Per Serving % Daily Value
Pantothenic Acid (as calcium pantothenate) 50 mg 500%
Magnesium (as citrate) 25 mg 6%
Passionflower (Passiflora incarnata flower) (standardized 3.5%–4% [2.6–3 mg] isovitexin/vitexins) 75 mg †
GABA (gamma-aminobutyric acid) 25 mg †
Eleuthero (Eleutherococcus senticosus root) (standardized 0.8% [0.2 mg] eleutherosides) 25 mg †
Chamomile (Matricaria recutita flower) (standardized 1% [0.25 mg] apigenin) 25 mg †
Hops (Humulus lupulus fruit) (standardized 5.2% [0.52 mg] bitter acids) 10 mg †
Pyridoxal-5-Phosphate (P-5-P) 6 mg †
* Percent Daily Values are based on a 2,000 calorie diet. † Daily Value (DV) not established.
Other Ingredients: Microcrystalline cellulose, di-calcium phosphate, stearic acid, hydroxypropyl methylcellulose, vegetable cellulose, magnesium stearate, silica, pharmaceutical glaze. Dietary Considerations & Allergen Status:
  • Gluten-Free & Vegetarian
  • Hypoallergenic formulation
  • Free from artificial colors and artificial preservatives
  • Free from common allergens: yeast, wheat, corn, soy, and milk/dairy

Suggested Use & Storage

Directions: As a dietary supplement for adults, take one (1) bi-layered tablet twice daily as needed to support calm relaxation and emotional well-being, or as recommended by your qualified healthcare practitioner. Storage: Keep container tightly closed in a cool, dry place. Keep out of reach of children. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Frequently Asked Questions

How does the bi-layered technology in Kalm-Assure 60 work?

Kalm-Assure utilizes a two-tier compression tablet. The first layer disintegrates rapidly after ingestion, delivering fast-acting pantothenic acid and GABA into circulation for immediate nervous system support. The second layer contains a micro-gel sustained release matrix that slowly liberates standardized passionflower, hops, chamomile, eleuthero, magnesium, and P-5-P over several hours, ensuring sustained calm without dramatic peaks or drop-offs.

Will Natures Plus Kalm-Assure make me drowsy during the day?

No. Kalm-Assure is formulated to be non-drowsy. Rather than sedating the central nervous system, it combines inhibitory GABA, adaptogenic eleuthero, and relaxing botanicals to moderate nervous agitation while preserving daytime focus, cognitive clarity, and productive energy.

Why does Kalm-Assure include P-5-P instead of regular Vitamin B6?

Pyridoxal-5-Phosphate (P-5-P) is the enzymatically active coenzyme form of Vitamin B6. Unlike generic pyridoxine hydrochloride, which must first be processed and phosphorylated in the liver, P-5-P is immediately biologically active. It serves as an essential cofactor for neurotransmitter synthesis—specifically assisting the conversion of amino acids into calming neurochemicals like GABA.

Can I take Kalm-Assure with other supplements or prescription medications?

Kalm-Assure contains bioactive botanicals (such as passionflower and hops) and GABA, which support calming neurochemical pathways. If you are currently taking prescription sedatives, anti-anxiety medications, monoamine oxidase inhibitors (MAOIs), or blood pressure medications, consult your physician or pharmacist before beginning supplementation to avoid potential interactions.

Is Natures Plus Kalm-Assure 60 suitable for vegetarians and those with food sensitivities?

Yes. Kalm-Assure is certified gluten-free, vegetarian, and hypoallergenic. It is manufactured without artificial colors, synthetic preservatives, yeast, wheat, corn, soy, or dairy.
Helpful Customer Reviews



Supplemental Information