Source Naturals Vitamin B-6 500 mg Timed Release provides a targeted, extra-strength dose of pure pyridoxine hydrochloride designed for sustained physiological delivery. Vitamin B-6 serves as a foundational coenzyme across more than 100 enzymatic pathways in the human body, directing how you break down proteins, manufacture calming neurotransmitters, produce oxygen-carrying red blood cells, and keep cellular homocysteine levels in balance.
Key Pharmacokinetic Feature: Because Vitamin B-6 is completely water-soluble, standard immediate-release mega-doses are rapidly cleared by the kidneys. This proprietary timed-release matrix gradually disperses 500 mg of pyridoxine over several hours, ensuring consistent cellular availability while minimizing metabolic waste and stomach sensitivity.
✓ Extra-Potency 500 mg Pyridoxine HCl per Tablet
✓ Sustained Multi-Hour Release Profile
✓ Supports Serotonin, Dopamine & GABA Synthesis
✓ Vegetarian-Friendly & Free of Common Allergens
How Vitamin B-6 Works in Your Body: The Plain-English Science
Inside your liver, pyridoxine is converted into its metabolically active coenzyme form: pyridoxal 5'-phosphate (PLP). PLP acts like a master molecular key, unlocking enzymes that manage energy production, nervous system stability, and cellular renewal. Here is what this process looks like in daily life:
1. Amino Acid & Protein Metabolism
Vitamin B-6 allows your system to break down dietary protein into usable building blocks (amino acids) and reassemble them into muscle tissues, enzymes, and hormones. The higher your protein intake, the more B-6 your metabolism requires.
2. Brain Chemical & Mood Balance
PLP is a mandatory cofactor for enzymes that produce essential mood regulators: serotonin (emotional stability and sleep), dopamine (motivation and focus), and GABA (the brain’s primary calming chemical).
3. Cardiovascular Homocysteine Control
Homocysteine is an amino acid byproduct found in blood. High levels can irritate blood vessel linings. Working directly alongside folate and Vitamin B-12, Vitamin B-6 recycles homocysteine into benign antioxidants like glutathione.
4. Hemoglobin & Oxygen Transport
Vitamin B-6 initiates the synthesis of heme, the central iron-binding core of hemoglobin. Healthy hemoglobin ensures red blood cells can efficiently carry oxygen from your lungs to your muscles, heart, and brain.
Why Choose Timed-Release Pyridoxine Over Standard Capsules?
High-potency water-soluble vitamins face a biological challenge known as the renal clearance threshold. When an immediate-release 500 mg B-6 pill dissolves rapidly in the stomach:
Intestinal transporters become quickly saturated, absorbing only a fraction of the total dose.
Blood plasma experiences a sharp spike within 60 to 90 minutes.
The kidneys rapidly filter and excrete the excess unabsorbed pyridoxine through urine.
The Source Naturals Formulation Difference: Using a specialized cellulose-based micro-matrix, each tablet is engineered to dissolve steadily as it travels through the digestive tract. This controlled delivery creates an even, flat absorption curve. Your tissues receive a dependable trickle of active nutrient throughout the day, preventing sudden saturation and ensuring maximum cellular uptake.
Important Health Notice: Safety, Upper Limits & Sensible Use
Therapeutic Mega-Dose Advisory: The standard Recommended Dietary Allowance (RDA) for Vitamin B-6 ranges from 1.3 to 1.7 mg per day for healthy adults. At 500 mg per tablet, this formulation delivers 29,412% of the daily value. It is specifically intended for individuals requiring short-term, targeted therapeutic protocols under the guidance of a physician or licensed healthcare provider.
Understanding the Tolerable Upper Intake Level (UL)
The Food and Nutrition Board of the U.S. National Academies of Sciences, Engineering, and Medicine has set the adult Tolerable Upper Intake Level (UL) at 100 mg per day. Taking doses greater than 100 mg daily over prolonged durations (typically several months to years) carries a documented clinical risk of sensory peripheral neuropathy (temporary nerve irritation).
Warning Signs of High-Dose Exposure
If you take higher-dose Vitamin B-6, monitor your body closely. Discontinue use immediately and consult your doctor if you experience:
✓ Tingling, buzzing, or "pins-and-needles" in the toes, feet, or fingertips
✓ Numbness or reduced tactile sensitivity in your extremities
✓ Clumsiness, loss of coordination, or unsteady gait
Note: In peer-reviewed medical literature, sensory symptoms generally resolve upon immediate cessation of the supplement. Do not combine this product with multiple other multivitamins or B-complex formulations without calculating your total cumulative daily B-6 intake.
Peer-Reviewed Scientific Citations & Evidence
We ground all health information in verifiable, authoritative medical research to empower informed consumer choices:
National Institutes of Health (NIH), Office of Dietary Supplements: "Vitamin B6: Fact Sheet for Health Professionals." Outlines enzymatic cofactor duties in transamination, decarboxylation, neurotransmitter pathways, and established 100 mg/day UL parameters.
NIH Reference
Institute of Medicine (US) Standing Committee: "Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline" (1998). National Academies Press (US). Establishes human pharmacokinetic clearance models and no-observed-adverse-effect levels (NOAEL).
Toxicology in Vitro Journal: Vrolijk, M. F., et al. (2017). "The vitamin B6 paradox: What is the mechanism of vitamin B6-induced neuropathy?" Toxicology in Vitro, 44, 206–212. Clarifies how excessive unphosphorylated pyridoxine competes with active PLP at low cellular clearance points.
European Food Safety Authority (EFSA): "Scientific opinion on the tolerable upper intake level for vitamin B6" (2023 Update). EFSA Panel on Nutrition, Novel Foods and Food Allergens. Re-evaluates long-term population exposure metrics across high-potency oral preparations.
Complete Supplement Facts & Ingredient Listing
Supplement Facts
Serving Size: 1 Time Release Tablet
Servings Per Container: 100
Amount Per Serving% Daily ValueVitamin B-6 (as pyridoxine HCl) 500 mg29,412%Calcium (as dibasic calcium phosphate) 27 mg2%
* Percent Daily Values (% DV) are based on a 2,000 calorie diet.
Other (Inactive) Ingredients: Dibasic calcium phosphate, stearic acid, modified cellulose gum, silica, and magnesium stearate.
Allergen Free From: Contains NO yeast, dairy, egg, gluten, corn, soy, or wheat. Formulated without sugar, starch, salt, preservatives, or artificial colors, flavors, or fragrances.
Dietary Suitability: Suitable for vegetarians.
Suggested Use & Storage Instructions
Suggested Adult Use: Take 1 timed-release tablet daily with a substantial meal and a full glass of water, or as directed by your qualified healthcare professional. Do not exceed 1 tablet per day unless clinically supervised.
Proper Storage: Store in a cool, dry place away from direct sunlight and excess heat. Ensure the child-resistant cap is tightly closed after each use. Keep out of reach of children.
*Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Frequently Asked Questions (FAQ)
Why would someone need a 500 mg dose of Vitamin B-6?
While regular dietary needs are small (around 1.3 to 1.7 mg daily), doctors and functional medicine clinicians occasionally recommend high-potency Vitamin B-6 for targeted clinical applications. These include correcting documented malabsorption, supporting severe premenstrual fluid balance and mood shifts, managing medication-induced depletions (such as certain tuberculosis or blood pressure drugs), or supporting hyperhomocysteinemia protocols.
How does timed-release technology make a difference?
Vitamin B-6 is water-soluble. When taken as a standard rapid-dissolving tablet, high doses flood the bloodstream all at once, which quickly triggers renal excretion, meaning most of the vitamin ends up washed out in your urine. The timed-release tablet slowly dissolves across several hours, allowing cellular transporters to continuously absorb the nutrient throughout the day while minimizing stomach irritation.
Is 500 mg of Vitamin B-6 safe to take every day indefinitely?
No, daily intake of 500 mg is well above the adult Tolerable Upper Intake Level (UL) of 100 mg/day established by medical health authorities. Prolonged daily megadoses over months can cause sensory peripheral neuropathy (numbness, tingling, or weakness in feet and fingers). High-dose regimens should be temporary and supervised by a medical doctor, with periodic evaluations of plasma PLP levels.
Can pregnant or nursing women take this product?
No. While modest doses of Vitamin B-6 (10 mg to 25 mg) are sometimes used for pregnancy-related nausea, 500 mg is an extra-strength dosage that is not recommended during pregnancy or breastfeeding without explicit instruction and monitoring from an obstetrician.
Does this supplement contain any common food allergens?
Source Naturals Vitamin B-6 500 mg Timed Release is clean-label formulated. It contains no yeast, dairy, egg, gluten, corn, soy, or wheat. Additionally, it contains no sugar, starch, salt, artificial colors, flavors, or chemical preservatives, and it is suitable for vegetarians.
'The B-6 vitamin promotes a very healthy immune system and recycles homo-cysteine back to the amino methionine preventing an unwanted build up of homo-cysteine. It is a nutrient required for the metabolism of lipids, carbohydrates, and proteins. It facilitates the conversion of amino acids from one to another as needed, and is necessary for normal synthesis of hemoglobin.
