Source Naturals BioPerine® Black Pepper Fruit Extract 10 mg (120 Tablets)
Unlock the full power of your daily supplements. You are not just what you eat—you are what you actually absorb. Many of the most powerful natural wellness compounds, like curcumin, CoQ10, and fat-soluble vitamins, pass right through your digestive tract without ever entering your bloodstream.
Source Naturals BioPerine® Black Pepper Fruit Extract 10 mg (Item # SN0644) is a patented, standardized extract containing 95% pure piperine. Designed specifically as a natural bioavailability enhancer, it acts like a biological key, gently helping your intestinal walls absorb vital nutrients so you get the maximum benefit out of every dollar you spend on your health routine.
✓ 95% Pure Piperine Standardized extract from Piper nigrum fruit.
✓ Up to 2,000% Boost Clinically proven to multiply curcumin uptake.
✓ Non-Irritating Tablet Gentle on the stomach and 100% vegetarian.
How BioPerine® Works: The Science of Bioavailability Made Simple
"Bioavailability" simply means how much of a nutrient survives digestion and enters your bloodstream where your cells can actually use it. Normally, your body treats many potent herbal extracts and micronutrients as foreign substances, quickly breaking them down in the liver or flushing them out before they can help you.
BioPerine® changes that through three primary biological mechanisms:
Piperine triggers a natural, localized warming effect in your gastrointestinal tract known as thermogenesis. This gentle metabolic process increases blood flow to the microvilli (the tiny absorbing fingers lining your gut), opening up pathways for nutrients to pass across the intestinal barrier quickly and easily.
2. Calms Down the Liver's "Clearance" Switch (Glucuronidation)
When you take supplements like curcumin (turmeric) or resveratrol, your liver attaches a chemical tag to them through a process called glucuronidation, signaling your kidneys to flush them out within minutes. Piperine temporarily slows this process down, keeping active nutrients circulating in your bloodstream for hours longer.
3. Relaxes the Cellular "Bouncers" (P-Glycoprotein)
Your gut cells have microscopic pump proteins (called P-glycoprotein) that act like overprotective security guards, pumping beneficial nutrients straight back out of your intestinal cells before they can reach your blood. BioPerine® temporarily quiets these pumps, letting the good nutrients slip safely into circulation.
Which Nutrients Benefit Most from BioPerine® 10 mg?
Taking BioPerine® alongside your other daily vitamins and botanicals helps you get greater potency out of standard serving sizes. Decades of clinical research have proven its bio-enhancing effects across several key nutrient groups:
Nutrient Target
Clinical Absorption Boost
Key Research Finding
Curcumin (Turmeric Extract)
Up to 2,000% Increase
Human clinical trials confirmed that pairing 20 mg of piperine with 2,000 mg of curcumin increased bioavailability by 20-fold compared to curcumin alone (Shoba et al., 1998).
Coenzyme Q10 (CoQ10)
Approx. 30% Increase
A double-blind trial demonstrated that adding just 5 mg of BioPerine® significantly elevated plasma concentrations of CoQ10 over a 21-day supplementation period (Badmaev et al., 2000).
Beta-Carotene & Fat-Soluble Vitamins
Approx. 60% Increase
Participants supplementing with beta-carotene alongside BioPerine® achieved a 60% higher area under the plasma curve (AUC) than those taking beta-carotene alone (Badmaev et al., 1999).
Essential Minerals (Iron, Zinc, Selenium)
30% to 50% Increase
Supports active gastrointestinal mineral transport, helping the body absorb trace minerals like selenium that often struggle with poor absorption in standard diets.
Water-Soluble B-Vitamins (B6, Vitamin C)
Elevated Blood Levels
Studies demonstrated elevated maximum blood serum levels of Pyridoxine (Vitamin B6) when ingested with BioPerine® versus placebo.
Because Source Naturals BioPerine® is so effective at opening up absorption channels, it does not discriminate between dietary supplements and pharmaceutical drugs. This is why the bottle carries an explicit label warning: "Do not take BioPerine® with medication."
Why BioPerine® Affects Prescription Medications
BioPerine® temporarily inhibits the Cytochrome P450 3A4 (CYP3A4) liver enzyme and the P-glycoprotein efflux pump (Bhardwaj et al., 2002). These two bodily systems are responsible for metabolizing more than 50% of all modern pharmaceutical medications. When piperine slows them down, prescription drugs can enter your bloodstream at unexpectedly high levels, essentially causing an unintentional overdose or dangerous side effects.
Do not combine with prescription medications such as blood thinners (Warfarin/Coumadin), blood pressure drugs, heart medications (Digoxin), anti-seizure medications (Phenytoin), anti-depressants, or immunosuppressants.
Pregnancy & Nursing: If you are pregnant, planning to become pregnant, or breastfeeding, do not use BioPerine® without explicit approval from your OB-GYN.
Timing Rule: If you take prescription medications daily, consult your physician or compounding pharmacist. Most healthcare providers recommend separating piperine intake from prescription medications by at least 3 to 4 hours, or avoiding it altogether.
How to Take Source Naturals BioPerine® for Optimal Results
Follow these straightforward rules to get the safest and most potent results from your bottle:
Suggested Serving Size
Take 1 tablet daily. For targeted therapeutic protocols, you may take 1 tablet twice daily, but do not exceed 2 tablets (20 mg total piperine) per day unless directed by your healthcare practitioner.
Best Timing
For maximum digestive uptake, take your tablet 30 to 60 minutes before your main meal, or swallow it directly alongside the target fat-soluble nutrients (like your turmeric/curcumin, CoQ10, or fish oil).
Pair with Healthy Fats
Piperine is naturally fat-soluble. Consuming your tablet with a glass of water and a meal containing healthy fats (such as avocado, olive oil, eggs, or nuts) enhances its absorption through the gut wall.
Source Naturals adheres strictly to FDA Good Manufacturing Practices (cGMP). Every tablet delivers a verified clinical dose with zero hidden fillers or artificial dyes.
Supplement Facts
Serving Size: 1 Tablet Servings Per Container: 120 Tablets
Amount Per Serving
% Daily Value
Calcium (as dibasic calcium phosphate)
27 mg (2% DV)
Black Pepper Fruit Extract (BioPerine®) Standardized to yield 95% Piperine (9.5 mg)
10 mg †
† Daily Value (DV) not established.
Other Ingredients: Dibasic calcium phosphate, microcrystalline cellulose, stearic acid, and magnesium stearate.
Dietary Suitability: Suitable for vegetarians. Contains NO yeast, dairy, egg, gluten, corn, soy, or wheat. Free of sugar, starch, salt, artificial preservatives, colors, flavors, or fragrances.
Storage: Store in a cool, dry place. Do not use if either tamper-evident neck seal or inner seal is broken or missing. Keep out of reach of children.
Frequently Asked Questions (FAQ)
Why can't I just grind regular kitchen black pepper onto my food?
Raw culinary black pepper only contains between 3% and 9% piperine by weight, along with volatile oils that can irritate your stomach lining in large amounts. To get the 9.5 mg of pure piperine found in a single Source Naturals tablet, you would need to consume roughly a heaping tablespoon of coarsely ground black pepper every day. BioPerine® provides an isolated, standardized 95% concentration that gives you maximum absorption benefits in one tiny, non-irritating tablet.
Will taking BioPerine® burn or upset my stomach?
No. While eating raw black pepper can trigger heartburn or acid reflux due to the pungent spicy oils, clinical trials have proven that purified BioPerine® is gentle and non-irritating to the gastrointestinal mucosa at standard 10 mg to 20 mg doses.
Why is calcium listed in the supplement facts?
Each tablet contains 27 mg of calcium (2% of your Daily Value) derived from dibasic calcium phosphate. This is a clean, inert mineral binder used during tablet manufacturing to ensure the tablet holds its shape without breaking and dissolves consistently once swallowed.
Can I take BioPerine® every single day?
Yes, healthy adults who are not on prescription medications can safely use BioPerine® daily to support nutrient absorption. If you ever start a course of prescription medication (such as antibiotics, blood thinners, or blood pressure drugs), temporarily discontinue BioPerine® and consult your doctor.
How long before a meal or other supplements should I take it?
For best results, take 1 tablet 30 to 60 minutes before your meal. Alternatively, if you take large herbal extracts like Curcumin or CoQ10 with food, you can swallow your BioPerine® tablet at the exact same time as those supplements.
Scientific References & Authoritative Citations
In accordance with our commitment to medical accuracy and evidence-based nutrition, all physiological claims regarding BioPerine® are supported by peer-reviewed published literature:
Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. S. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64(4), 353–356. doi:10.1055/s-2006-957450.
Badmaev, V., Majeed, M., & Prakash, L. (2000). Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. The Journal of Nutritional Biochemistry, 11(2), 109–113. doi:10.1016/S0955-2863(99)00074-1.
Badmaev, V., Majeed, M., & Norkus, E. P. (1999). Piperine, an alkaloid derived from black pepper, increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation. Nutrition Research, 19(3), 381–388. doi:10.1016/S0271-5317(99)00007-X.
Bhardwaj, R. K., Glaeser, H., Becquemont, L., Klotz, U., Gupta, S. K., & Fromm, M. F. (2002). Piperine is a potent inhibitor of human P-glycoprotein and CYP3A4. Journal of Pharmacology and Experimental Therapeutics, 302(2), 645–650. doi:10.1124/jpet.102.034728.
Srinivasan, K. (2007). Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Critical Reviews in Food Science and Nutrition, 47(8), 735–748. doi:10.1080/10408390601062054.
FDA Disclaimer: The statements made regarding this product have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Medical Notice: The educational content on this page is for informational purposes only and is not a substitute for professional medical diagnosis, advice, or treatment. Always consult a qualified physician or pharmacist before beginning any new dietary supplement, especially if you take prescription medications or have a diagnosed health condition.
