Reclaim your mental sharpness, clear daily brain fog, and support natural hormonal rhythm. Often called the “mother hormone,” pregnenolone is the primary foundation your brain and body use to create essential hormones and keep neurotransmitters firing smoothly.
✓ 25 mg Clinically Balanced Dose
SN0678 | UPC: 021078006787 | Form: Tablets
To understand pregnenolone, think of your endocrine system like a giant tree. Pregnenolone is the trunk of that tree. Your body takes cholesterol inside the mitochondria (the power plants of your cells) and converts it into pregnenolone. From there, your body branches out into various critical messengers: DHEA, progesterone, testosterone, estrogen, and cortisol.
Because it stands at the very beginning of this chemical pathway, scientists call it a pro-hormone or neurosteroid precursor. Your body only borrows what it needs along each pathway.
Natural pregnenolone production peaks in our early 20s. By age 70 to 75, average circulating levels can drop by up to 60%. This steep drop often coincides with common mid-life complaints: slower word recall, mental fog, daytime fatigue, lower stamina, and mood shifts. Supplementing with a moderate 25 mg dose helps restore raw precursor supplies without overloading your system.
Pregnenolone does two big jobs: it directly fuels brain receptors (as a neurosteroid) and it supplies raw material for downstream vitality hormones. Here is how that translates to your everyday life:
Unlike hormones that only circulate in the bloodstream, pregnenolone is concentrated in the brain up to several times higher than in peripheral blood. It interacts with NMDA receptors (which govern synaptic plasticity and memory formation) and balances GABA receptors (which govern calm and focus). Landmark research published in the Proceedings of the National Academy of Sciences (PNAS) demonstrated that pregnenolone sulfate directly enhances memory retention and neural firing pathways.
Pioneering clinical studies conducted by researchers Dr. Gregory Pincus and Dr. Hudson Hoagland tested pregnenolone in individuals undergoing sustained physical and mental stress (such as aviators and industrial workers). They documented significant improvements in psychomotor precision, hand-eye coordination, and a noticeable reduction in perceived physical exhaustion.
When prolonged stress depletes your adrenal glands, your body frequently prioritizes cortisol production over other wellness hormones (a phenomenon often called the “pregnenolone steal”). Providing a pure 25 mg starting dose helps support mood stability, eases anxious reactivity, and helps you feel more grounded through challenging workdays.
Many generic brands offer mega-doses of 50 mg, 100 mg, or even 200 mg. However, in the world of hormone precursors, more is not better – balance is better.
Because pregnenolone influences active steroid hormone synthesis, it should be approached with care and medical oversight. Please read these clinical precautions thoroughly before starting:
Do NOT use if:
Consult your physician first if:
You take prescription medications such as corticosteroids, hormone replacement therapy (HRT), oral contraceptives, thyroid hormones, or benzodiazepines/sedatives. Have your blood levels of total/free testosterone, estradiol, progesterone, and DHEA-S tested by your doctor before starting, and recheck them after 30 days of consistent use.
Every batch of Source Naturals Pregnenolone is produced under strict current Good Manufacturing Practices (cGMP) in the USA. VitaNet® guarantees 100% genuine inventory stored in climate-controlled facilities.
Serving Size: 1 Tablet
Servings Per Container: 120
| Amount Per Serving | % Daily Value |
|---|---|
| Vitamin C (as ascorbyl palmitate) – 10 mg | 11% |
| Calcium (from dibasic calcium phosphate) – 21 mg | 2% |
| Pregnenolone – 25 mg | † |
† Daily Value not established.
Other Ingredients: Dibasic calcium phosphate, microcrystalline cellulose, sorbitol, stearic acid, silica (colloidal silicon dioxide), and magnesium stearate.
Excipient Purpose (Clean Transparency): Dibasic calcium phosphate and microcrystalline cellulose provide clean tablet structure; sorbitol aids dissolution; vegetable stearic acid, silica, and magnesium stearate guarantee smooth, non-clumping compression without synthetic chemical binders.
Dietary Suitability: Suitable for vegetarians. Contains NO yeast, dairy, egg, gluten, corn, soy, wheat, sugar, artificial starch, preservatives, synthetic color, or artificial flavors.
Standard Dose: Take 1 tablet daily, preferably in the morning with a breakfast containing healthy fats (such as avocado, eggs, or yogurt) for optimal fat-soluble absorption.
Conservative Starting Protocol: If you are new to hormone supplements, begin with 1/2 tablet (12.5 mg) daily for the first 7 to 10 days to monitor how your body responds.
Maximum Daily Limit: Do not exceed 2 tablets (50 mg) per day unless specifically monitored and prescribed by your healthcare provider.
Cycling Strategy: Many hormone specialists recommend cycling pregnenolone (for example, taking it 5 days on, 2 days off, or taking it for 30 consecutive days followed by a 1 to 2-week break and a routine blood panel).
VitaNet® supports high editorial principles. The claims on this page are grounded in peer-reviewed clinical and biochemical literature:
Pregnenolone sits one level higher in the hormone chain than DHEA. While DHEA converts almost exclusively into androgens and estrogens (testosterone and estrogen), pregnenolone can convert into DHEA or down the progesterone and neurosteroid pathway. Pregnenolone therefore tends to offer broader cognitive, memory, and nervous system support compared to DHEA alone.
Many people report subtle improvements in mental alertness, concentration, and calm energy within 5 to 14 days of daily use. For deeper hormonal balance and stamina benefits, allow 3 to 4 weeks of consistent intake alongside healthy diet and sleep hygiene.
Yes, adult women often utilize pregnenolone 25 mg to support mental sharpness and navigate natural mid-life hormonal transitions. However, women who are pregnant, nursing, or who have hormone-sensitive conditions (such as endometriosis, uterine fibroids, or estrogen-positive breast cancer) must avoid it. Routine hormone panels are advised for all users.
When taken at responsible doses like 25 mg, adverse effects are uncommon. However, excessive doses can cause symptoms of hormone imbalance, including oily skin, mild acne breakouts, restless sleep, mild irritability, or headaches. If you notice any of these signs, discontinue use or reduce your dosage to half a tablet.
VitaNet® has served health-conscious shoppers online since 1995. Every bottle of Source Naturals Pregnenolone (Item SN0678) is 100% factory-sealed, stored in strict temperature-controlled conditions, and backed by a 30-day satisfaction guarantee with immediate warehouse dispatch.