SOURCE NATURALS: Inflama Trim 120 Tablets

Inflama Trim - 120 Tablets



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UPC: 021078020721
# SN2072
Evidence-Based Clinical Monograph SKU: SN2072 UPC: 021078020721 Brand: Source Naturals® Form: 120 Tablets | 60 Servings Scientifically Reviewed by: VitaNet® Nutritional Sciences Editorial Board

Source Naturals Inflama-Trim™ (120 Tablets): Targeted Metabolic, Glycemic, and Anti-Inflammatory Support

Source Naturals Inflama-Trim™ is an advanced, bio-aligned dietary supplement engineered to address the physiological triad of weight management resistance: chronic low-grade systemic inflammation (metaflammation), dysregulated hypothalamic-pituitary-adrenal (HPA) axis cortisol secretion, and impaired insulin sensitivity. By integrating 35 clinically substantiated botanical extracts, metabolic enzymes, and micronutrients, Inflama-Trim™ delivers systemic support that transcends standard caloric-restriction diet pills.

The Science of Weight Resistance: Resolving "Metaflammation"

Conventional weight-loss formulations rely heavily on acute central nervous system stimulants, failing to address the primary biochemical driver of stubborn adiposity: metabolic inflammation (also known as metaflammation). Modern nutritional immunology demonstrates that expanding visceral adipose tissue triggers macrophage infiltration, causing sustained elevation of inflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF-a), Interleukin-6 (IL-6), and C-Reactive Protein (CRP) (Hotamisligil, 2006).

These elevated circulating cytokines activate the I?B kinase-ß (IKK-ß)/NF-?B pathway, inducing serine phosphorylation of Insulin Receptor Substrate 1 (IRS-1). The result is impaired cellular glucose uptake via GLUT-4 transporters, compensatory hyperinsulinemia, elevated lipoprotein lipase activity, and preferential fat storage over lipid oxidation. Source Naturals Inflama-Trim™ breaks this cycle through targeted botanical modulators designed to restore metabolic equilibrium at the cellular level.

The 5-System Bio-Aligned™ Framework

Source Naturals formulates according to systems biology, targeting five interconnected physiological pathways that govern body composition:

  • Inflammatory Cascade Regulation: High-potency Curcumin (95% curcuminoids), Hops (Perluxan®), and Bromelain downregulate NF-?B and Cyclooxygenase-2 (COX-2) expression without gastrointestinal mucosal toxicity (Aggarwal et al., 2009).
  • Glycemic & Carbohydrate Modulation: Phase 2® White Kidney Bean Extract inhibits salivary and pancreatic alpha-amylase, while standardized Cinnamon, Banaba (corosolic acid), and ChromeMate® Chromium potentiate peripheral insulin signaling (Celleno et al., 2007).
  • Neuroendocrine & Cortisol Balance: Relora® (patented Phellodendron amurense and Magnolia officinalis bark complex) and Holy Basil normalize stress-induced salivary cortisol, mitigating visceral lipid deposition caused by 11ß-HSD1 enzyme activity (Talbott et al., 2013).
  • Thermogenesis & Mitochondrial ß-Oxidation: Standardized Green Tea Extract (EGCG) synergizes with Acetyl-L-Carnitine and Alpha-Lipoic Acid (ALA) to stimulate carnitine palmitoyltransferase-1 (CPT-1) and enhance resting energy expenditure (Hursel et al., 2009).
  • Pharmacokinetic Enhancement: BioPerine® (standardized black pepper extract) inhibits hepatic and intestinal glucuronidation, increasing the bioavailability of active polyphenols by up to 2,000% (Shoba et al., 1998).

Complete Ingredient Analysis & Biochemical Roles

Every two-tablet serving of Source Naturals Inflama-Trim™ (SN2072) provides a broad spectrum of pharmaceutical-grade nutrients, standardized herbal extracts, and co-factors designed to operate in metabolic synergy.

Active Ingredient Amount Per Serving (2 Tablets) % Daily Value Standardized Marker / Primary Mechanism
Vitamins, Minerals & Essential Nutrients
Vitamin C (naturally occurring) 1 mg 2% Cellular antioxidant protection against lipid peroxidation
Niacin (as niacinamide) 10 mg 62% Coenzyme for NAD+/NADH energy substrate pathways
Vitamin B-6 (as pyridoxine HCl) 10 mg 588% Cofactor for decarboxylation and neurotransmitter synthesis
Pantothenic Acid (as calcium D-pantothenate) 33 mg 660% Obligate precursor to Coenzyme A (CoA) in fatty acid metabolism
Iodine (as potassium iodide) 26 mcg 17% Substrate for thyroid hormone synthesis (T3/T4) and basal metabolic rate
Magnesium (as magnesium chelate) 33 mg 8% ATP stabilization and insulin-receptor tyrosine kinase activation
Chromium (as ChromeMate® polynicotinate & picolinate) 100 mcg 286% Activates chromodulin to enhance insulin sensitivity
Sodium 10 mg <1% Electrolyte balance
Potassium (as potassium citrate) 6 mg <1% Intracellular fluid homeostasis and neuromuscular function
Vanadium (as vanadyl sulfate pentahydrate) 5 mcg * Mimics post-receptor insulin actions to facilitate cellular glucose uptake
Inflammatory Response & Antioxidant Defense Complex
Turmeric Root Extract (95% curcuminoids) 122 mg * Downregulates NF-?B, TNF-a, and COX-2 gene transcription
Hops Cone Extract (yielding 30 mg Humulex™ alpha-acids [Perluxan®]) 100 mg * Selective biological COX-2 inhibitor; supports joint comfort
Bromelain (2,000 G.D.U. per gram) 50 mg * Proteolytic enzyme that cleaves inflammatory circulating immune complexes
N-Acetyl Cysteine (NAC) 33 mg * Rate-limiting intracellular precursor to reduced glutathione (GSH)
Ginger Root (Zingiber officinale) 33 mg * Inhibits leukotriene synthesis via 5-lipoxygenase (5-LOX) pathway
Natural trans-Resveratrol (from Polygonum cuspidatum) 5 mg * SIRT1 deacetylase activator; promotes mitochondrial biogenesis
Rosemary Leaf Extract (20% polyphenols) 16 mg * Carnosic acid source neutralizing reactive oxygen species (ROS)
Glycemic Control & Carbohydrate Metabolism
Phase 2® Carb Controller (Phaseolus vulgaris bean extract) 100 mg * Standardized glycoprotein that neutralizes alpha-amylase enzyme activity
Cassia Bark Extract (Cinnamomum spp.) 100 mg * Type-A polyphenol polymers; enhances GLUT4 glucose transporter migration
Gymnema Leaf Extract (25% gymnemic acids) 44 mg * Blocks intestinal sweet taste receptors and enteric glucose absorption
Banaba Leaf Extract (standardized corosolic acid) 13 mg * Direct activation of cellular glucose phosphorylation
Bitter Melon Fruit Extract (4:1) 16 mg * Contains charantin and polypeptide-p; supports pancreatic beta-cell function
Apple Cider Vinegar 50 mg * Acetic acid delays gastric emptying and flattens postprandial glucose spikes
Thermogenic & Lipid Oxidation Complex
Green Tea Leaf Extract (standardized to 50% caffeine [100 mg]) 200 mg * Inhibits catechol-O-methyltransferase (COMT) to sustain norepinephrine
Acetyl-L-Carnitine HCl 100 mg * Shuttles long-chain fatty acids into mitochondria for ß-oxidation
alpha-Lipoic Acid (ALA) 100 mg * Mitochondrial dehydrogenase cofactor; activates AMPK cellular energy switch
Garcinia Fruit Extract (50% hydroxycitric acid [HCA]) 100 mg * Inhibits ATP-citrate lyase, an enzyme necessary for de novo lipogenesis
Guggul Extract (10% guggulsterones) 82 mg * Antagonizes farnesoid X receptor (FXR); supports thyroidal metabolic rate
Chitosan 66 mg * Positively charged dietary fiber that complexes with dietary lipids in the gut
Phytosterol Complex (40% beta-sitosterol) 25 mg * Competitively displaces intestinal micellar cholesterol absorption
Stress Response, Cortisol & Neurotransmitter Support
Relora® (Phellodendron amurense & Magnolia officinalis) 100 mg * Binds central GABA-A receptors; mitigates stress-induced hypercortisolemia
Holy Basil Leaf Extract (Tulsi / Ocimum sanctum) 100 mg * Adaptogenic support modulating stress biomarkers and corticotropin-releasing hormone
GABA (gamma-aminobutyric acid) 33 mg * Primary inhibitory neurotransmitter; attenuates nervous-tension-induced cravings
L-Phenylalanine 50 mg * Precursor to cholecystokinin (CCK), the gastrointestinal satiety peptide
L-Tyrosine 33 mg * Immediate amino acid substrate for dopamine and catecholamine biosynthesis
L-Theanine 16 mg * Promotes alpha-brainwave synchronization to counter caffeine jitteriness
Hepatic Elimination, Fluid Balance & Bioavailability
Dandelion Root Extract (4:1) & Leaf Extract (4:1) 19 mg * Supports Phase I/II hepatic xenobiotic excretion and natural fluid balance
Fenugreek Seed Extract (4:1) 25 mg * High galactomannan soluble fiber; delays carbohydrate absorption
Bladderwrack Leaf Extract (4:1) 10 mg * Organic marine trace mineral source enhancing metabolic vitality
Bupleurum Root Extract (5% saikosaponins) 5 mg * Traditional harmonizing adaptogen for systemic homeostasis
Black Pepper Fruit Extract (BioPerine®) 1 mg * Clinically validated piperine extract to amplify enteric nutrient absorption

*Daily Value (%DV) not established.
Other Ingredients: Silicified microcrystalline cellulose, stearic acid, silica, and modified cellulose gum.
Allergen Warning: Contains Shellfish (chitosan from shrimp/crab) and Soy.

Evidence-Based Administration Protocol

To achieve optimal metabolic synchronization, nutrient absorption, and digestive comfort, adhere to the following clinical administration guidelines:

Standard Therapeutic Dosage

Take 2 tablets, three times daily, precisely 15 to 30 minutes before your primary meals with an 8-ounce glass of pure water.

Timing Alpha-Amylase Inhibition

Pre-prandial (before-meal) intake is mandatory. Phase 2® white kidney bean extract requires 15–30 minutes to transit into the duodenum to bind and inhibit digestive alpha-amylase enzymes prior to carbohydrate ingestion.

Circadian Caffeine Optimization

Each 2-tablet serving contains approximately 100 mg of caffeine (equivalent to one 8-ounce cup of coffee) sourced from Green Tea Extract. To preserve sleep architecture and avoid nocturnal cortisol elevations, consume your final daily dose no later than 4:00 PM.

Integration with Lifestyle

Inflama-Trim™ is designed to accompany the Maximum Metabolism Weight Loss Plan™. For maximum metabolic synergy, pair with a whole-food anti-inflammatory diet (low in ultra-processed sugars and industrial seed oils) and moderate resistance training.

Clinical Precautions, Interactions, and Contraindications

As part of VitaNet's commitment to high medical transparency and consumer safety, review these crucial physiological considerations before initiating supplementation:

Absolute Contraindications

Potential Drug Interactions & Precautions

Peer-Reviewed Scientific References

  1. Hotamisligil, G. S. (2006). Inflammation and metabolic disorders. Nature, 444(7121), 860–867. DOI: 10.1038/nature05485.
  2. Aggarwal, B. B., & Harikumar, K. B. (2009). Potential therapeutic effects of curcumin, the anti-inflammatory agent, against metabolic and autoimmune diseases. The International Journal of Biochemistry & Cell Biology, 41(1), 40–59.
  3. Celleno, L., Tolaini, M. V., D'Amore, A., Perricone, N. V., & Preuss, H. G. (2007). A dietary supplement containing standardized Phaseolus vulgaris extract influences body composition of overweight men and women. International Journal of Medical Sciences, 4(1), 45–52.
  4. Talbott, S. M., Talbott, J. A., & Pugh, M. (2013). Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological state in moderately stressed subjects. Journal of the International Society of Sports Nutrition, 10(1), 37.
  5. Hursel, R., Viechtbauer, W., & Westerterp-Plantenga, M. S. (2009). The effects of green tea on weight loss and weight maintenance: a meta-analysis. International Journal of Obesity, 33(9), 956–961.
  6. Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. S. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64(04), 353–356.

Frequently Asked Questions About Source Naturals Inflama-Trim™

How does Source Naturals Inflama-Trim differ from standard thermogenic fat burners?

Standard diet pills focus almost exclusively on elevating heart rate and core temperature using high doses of synthetic caffeine or bitter orange (synephrine). This approach often triggers rebound adrenal stress, raising cortisol and worsening visceral belly fat accumulation. In contrast, Source Naturals Inflama-Trim™ is a multi-system Bio-Aligned Formula®. It targets the biochemical roots of stubborn weight: reducing chronic cytokine-driven metaflammation (via Curcumin and Hops), moderating cortisol (via Relora®), blunting digestive carbohydrate absorption (via Phase 2®), and optimizing peripheral insulin sensitivity (via Chromium and Cinnamon), without causing stimulant burnout.

How much caffeine is contained in each serving of Inflama-Trim?

A full two-tablet serving delivers approximately 100 mg of naturally derived caffeine from standardized Green Tea Leaf Extract. This is roughly the amount found in one standard 8-ounce cup of brewed coffee. The inclusion of calming neuro-nutrients such as L-Theanine and GABA helps moderate the sympathetic spike, promoting smooth, steady alertness without jitteriness.

When should I take Inflama-Trim for the best results?

Clinical administration calls for 2 tablets taken 15 to 30 minutes before meals, up to three times daily. This precise timing is essential because Phase 2® white kidney bean extract must reach the digestive tract prior to carbohydrate ingestion to effectively block alpha-amylase enzymes. To prevent sleep disruption from green tea caffeine, schedule your final daily dose in the mid-afternoon.

Is Inflama-Trim safe for individuals with shellfish allergies?

No. Inflama-Trim™ contains Chitosan, a natural fat-binding fiber derived from crustacean shellfish (shrimp and crab). Anyone with a documented allergy or anaphylactic sensitivity to shellfish must strictly avoid this supplement.

Can I take Inflama-Trim if I am currently taking prescription diabetes medication?

You should consult your healthcare provider prior to use. Inflama-Trim™ contains bioactive glucose modulators (including Chromium polynicotinate, Cassia bark, Banaba extract, and Vanadyl sulfate) that enhance cellular insulin sensitivity. When combined with prescription hypoglycemic agents such as Metformin or Insulin, blood sugar levels may decrease more rapidly than anticipated, necessitating closer glucose monitoring.

What is Phase 2® Carb Controller, and how does it block starch absorption?

Phase 2® is a clinically researched, standardized extract of the non-GMO white kidney bean (Phaseolus vulgaris). It acts as an alpha-amylase enzyme inhibitor. By temporarily preventing alpha-amylase from cleaving complex starches (such as bread, pasta, and rice) into absorbable glucose molecules, it reduces post-meal glucose spikes and decreases the net caloric absorption of starchy meals.

How does Relora® in Inflama-Trim help reduce stress eating?

Relora® is a patented blend of extracts from Phellodendron amurense and Magnolia officinalis. In double-blind clinical trials, Relora® demonstrated the ability to bind central GABA receptors, significantly reducing salivary evening cortisol levels and psychological stress. By lowering chronic cortisol elevations, it helps mitigate stress-induced food cravings and emotional carbohydrate binging.

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