Niacinamide 500mg – 60 Tablets | Non-Flushing Vitamin B-3 for Cellular Bioenergetics & Dermatological Health
Scientific Evidence Level: Level 1 Clinical & Toxicological Review | Brand: Source Naturals | Item #: SN2807 | UPC: 021078028079Niacinamide 500mg (also known as nicotinamide) is an essential, water-soluble form of Vitamin B-3 engineered to deliver optimal cellular nutrition without the uncomfortable cutaneous vasodilation—commonly known as the "niacin flush"—associated with standard nicotinic acid. As an indispensable precursor in human biochemistry, niacinamide is rapidly converted into Nicotinamide Adenine Dinucleotide (NAD+) and Nicotinamide Adenine Dinucleotide Phosphate (NADP+), two fundamental coenzymes powering cellular adenosine triphosphate (ATP) production and mitochondrial bioenergetics.
Manufactured by Source Naturals under strict Current Good Manufacturing Practices (cGMP), each single-tablet dose provides 500 mg of pure USP-grade niacinamide along with 45 mg of dibasic calcium phosphate to assist structural integrity and systemic uptake. Whether utilized for dermatological photoprotection, neurocellular support, or carbohydrate and lipid metabolism, Source Naturals Niacinamide 500mg delivers therapeutic potency backed by clinical literature.
Unlike synthetic metabolic enhancers, oral nicotinamide feeds directly into the salvage pathway of NAD+ biosynthesis via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT). Maintaining intracellular NAD+ reserves is critical for two vital cellular survival enzymes:
Extensive dermatological research has positioned oral niacinamide 500 mg as a primary nutritional therapy for skin photoprotection. In the landmark Phase III randomized, double-blind, placebo-controlled ONTRAC trial published in the New England Journal of Medicine, subjects supplementing with 500 mg of oral nicotinamide twice daily showed a statistically significant 23% reduction in new non-melanoma skin lesions (actinic keratoses and basal/squamous cell carcinomas) compared to placebo over a 12-month period (Chen et al., 2015). Researchers concluded that oral niacinamide prevents UV-induced ATP depletion in human keratinocytes and reverses cutaneous immune suppression.
A common question among consumers is the biochemical difference between niacin vs. niacinamide. Standard nicotinic acid activates the hydroxycarboxylic acid receptor 2 (HCA2 / GPR109A) located on dermal Langerhans cells and epidermal keratinocytes, triggering a rapid release of prostaglandins (specifically PGD2 and PGE2) that dilates blood vessels and causes intense, itchy facial flushing.
In contrast, Source Naturals Niacinamide does not bind or activate the GPR109A receptor. Consequently, users achieve full coenzymatic B-3 cellular saturation with zero cutaneous flushing, burning sensations, or sudden drops in peripheral vascular resistance.
Clinical investigations pioneered by Dr. William Kaufman established that divided daily doses of niacinamide support cartilage metabolism, joint flexibility, and subjective comfort in individuals experiencing age-related articular stiffness. Subsequent studies suggest this benefit stems from niacinamide’s suppression of pro-inflammatory cytokines (such as IL-1ß) within synovial fluid (Kaufman, 1953; Jonas et al., 1996).
Every batch undergoes rigorous identity, purity, and potency testing to ensure compliance with stringent dietary supplement GMP guidelines.
Serving Size: 1 Tablet
Servings Per Container: 60
| Amount Per Serving | % Daily Value |
|---|---|
| Calcium (as dibasic calcium phosphate) | 45 mg (3% DV) |
| Niacinamide (Vitamin B-3) | 500 mg (3,125% DV) |
Microcrystalline cellulose, dibasic calcium phosphate, hydroxypropyl cellulose, and magnesium stearate.
Suggested Use: Take 1 tablet 1 to 2 times daily with meals, or as recommended by your qualified healthcare professional. Consistent daily intake with food enhances gastrointestinal tolerance and supports stable systemic bioavailability.
While crystalline nicotinic acid is occasionally associated with altered hepatic transaminases at doses exceeding 1,500 mg/day, niacinamide exhibits a markedly wider safety margin. The European Food Safety Authority (EFSA) and the U.S. Food and Nutrition Board established that daily oral intakes of nicotinamide up to 900–1,000 mg/day in adults present no observable adverse health outcomes.
Cautions & Warnings:
No. Niacinamide is the non-flushing amide form of Vitamin B-3. The notorious "niacin flush" is triggered solely by nicotinic acid binding to the HCA2/GPR109A receptors on dermal cells, which triggers prostaglandin release. Because niacinamide does not bind to these receptors, it does not cause facial redness, warmth, or skin irritation.
Dermatologists frequently reference the Phase III ONTRAC clinical trial published in the New England Journal of Medicine, which evaluated oral nicotinamide at 500 mg taken twice daily (1,000 mg total). The study demonstrated that this exact dosage helps replenish cellular ATP lost to UV radiation, supports genomic DNA repair mechanisms (PARP-1), and preserves cutaneous immunity.
No. While nicotinic acid (the flushing form of B-3) is recognized for its ability to modulate LDL, HDL, and triglyceride metabolism, niacinamide does not possess this specific lipid-altering property. If your primary goal is cardiovascular lipid management, discuss nicotinic acid formulations with your prescribing physician.
It is best taken with a meal—such as breakfast and dinner if taking it twice daily. Consuming the tablet with food optimizes absorption and prevents mild stomach upset that sensitive individuals might experience when taking concentrated water-soluble vitamins on an empty stomach.
Yes, for healthy adults. International health authorities, including the European Food Safety Authority (EFSA), place the Upper Tolerable Intake Level (UL) for daily nicotinamide at approximately 900 mg to 1,000 mg per day with an established high margin of safety. Doses within this range do not cause the liver strain associated with high-dose sustained-release nicotinic acid.
No. Source Naturals Niacinamide 500mg contains no yeast, dairy, egg, gluten, soy, wheat, sugar, starch, salt, or artificial preservatives. It is formulated to be suitable for vegetarians.
