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The Benefits of the Amazing Duo of CoQ10 and Red Yeast Rice Darrell Miller 3/11/12
L-Methionine Darrell Miller 5/2/09
Possible Billions in Health Care Costs, why hasn’t the government stepped in? Darrell Miller 6/26/07
Turmeric and Alzheimer’s Disease Darrell Miller 5/10/07
CHOLESTEROL RESCUE - Maintain Your Cholesterol Wellness Darrell Miller 6/29/05



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The Benefits of the Amazing Duo of CoQ10 and Red Yeast Rice
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Date: March 11, 2012 03:08 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Benefits of the Amazing Duo of CoQ10 and Red Yeast Rice

What Is Cholesterol?

Cholesterol is a substance produced by the liver that provides a number of benefits to the body. A problem occurs when the level of blood LDL or bad cholesterol goes beyond a normal level. High level of bad cholesterol in the body can inflict damage to the arteries during the process of oxidation which can lead to the heavy accumulation of stiffened fats and deposits in the walls of the arteries. This can constrict the arteries that eventually lead to a minimal flow of oxygen-rich blood to the heart and brain. Inadequate supply of blood to the heart and brain can trigger heart attack and stroke. When the kidney perceives an inadequacy in the supply of blood to the brain and heart, it produces substances that help in increasing the supply of blood to these organs. However, in effect, it also increases blood pressure.

Many serious health complications emanate from abnormally high levels of bad cholesterol or low density lipoprotein (LDL) in the body. As people get older, their awareness about maintaining an optimum level of cholesterol should increase significantly. Undeniably, cardiovascular diseases that are triggered by high levels of cholesterol in the body have been one of the major causes of death worldwide.

Red Yeast Rice

Intake of red yeast rice is considered to be one of the most effective alternative ways to lower the level of cholesterol in the body. It is produced by fermenting a certain type of red yeast that is poured over the rice. Researchers believed that red yeast rice contains high levels of substance lovastatin that inhibits the production of enzyme HMG-CoA reductase which is responsible in regulating the production of cholesterol in the body. Red yeast rice actually contains sufficient amount of monacolin K and 8 more monacolin substances that are work like statin drugs in reducing the level of cholesterol. Basically, the substances prevent the liver from producing alarming level of bad cholesterol.

Lowering Effects of LDL

Red yeast rice is a great alternative choice for patients who are searching for non-prescription ways of lowering their cholesterol. A clinical study shows that red yeast rice can significantly lower the level of cholesterol in the body by as much as 20% without exposing the victim to the risk of suffering from muscle pain. Another study reveals that after taking 1800MG of RYR daily for 12 weeks, the users' bad cholesterol level have significantly drop by 27%.

Red yeast rice is actually an FDA-recognized dietary supplement. It is renowned for its capacity to work similar to a statin drug that effectively drives the body to achieve an optimum level of cholesterol. A number of scientific studies revealed that intake of red yeast rice can significantly lower the levels of bad cholesterol and triglycerides in the body. Furthermore, studies show that continuous intake of red yeast rice can contribute a lot in improving the amount of total cholesterol.

Together with red yeast rice, CoQ10 make an amazing duo in lowering the level of bad cholesterol in the body and promote overall cardiovascular health. Intake of CoQ10 is highly recommended to people who take red yeast rice because CoQ10 provides energy and strength to the heart when pumping blood to other organs. When used together, CoQ10 and red yeast rice can increase the transfer of oxygen and energy between the cells and the blood which leads to a significant reduction in the level of cholesterol produced.

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L-Methionine
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Date: May 02, 2009 11:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: L-Methionine

Methionine is an essential amino acid, meaning that it is not synthesized by the body, and so has to be taken as part of your diet. It also contains sulfur, one of two sulfur-containing amino acids that can form proteins, the other being cysteine. It is a precursor for taurine, which is an aminosulphonic acid, and not strictly an amino acid, which together with cysteine supports the health of your cardiovascular system and helps to eliminate toxins from the body.

Maintenance of Cell Membranes

It is also an important intermediary in the maintenance of cell membranes. Phospholipids are fat-soluble components of the cell membrane, phosphatidylcholine being a very important example. Also known as lecithin, this substance is derived from choline, itself biosynthesized in a chemical pathway involving S-adenosylmethionine.

This substance is made in the body from ATP (adenosine triphosphate) and methionine with the help of the enzyme methionine adensosyltransferase. Known as SAM (or SAM-e), S-adenosylmethionine employs a number of metabolic pathways in its reaction, though generally aminopropylation, transmethylation and transsulfuration. These add aminopropyl, sulfo and methyl groups to a number of substances, the most common being the methylation of proteins, nucleic acids and lipids.

Phosphatidylcholine is produced by the enzyme-catalyzed sequential methylation of phosphatidylethanolamine, SAM donating the methyl groups. The maintenance of the integrity of the cellular membrane by phosphatidylcholine is critical to all of the basic processes in human biology, including communication between cells, flow of information and bioenergetics.

A by-product of this reaction is homocysteine, formed in the liver from the S-adenosylhomocysteine that SAM is changed to after donating methyl groups. Excess homocysteine in the blood can create the risk of myocardial infarction and cardiovascular disease. SAM is also of use in the treatment of depression and of arthritis.

Muscle Development

Creatine is a substance well known to athletes as being useful in provide short-term energy for high-intensity training. Although available in the diet, about 50% creatine used by the body is biosynthesized from methionine and two other amino acids, glycine and arginine. It allows a burst of energy lasting about 10 seconds, carried out without the use of glycogen reserves or fatty tissue.

Glycine and arginine combine to release ornithine as a by-product, and form guanidino acetate. SAM donates a methyl group to the latter to form creatine, about 95% of which is then stored in the skeletal muscle tissue. The stored creatine phosphate has the effect of allowing the muscle cells to hold more water, which also enables an enhanced level of protein synthesis, and hence an increase in muscle bulk, which also results from the increased blood flow resulting from the short-term high-intensity exercise that creatine allows.

Creatine can also increase the levels of MRF4 (myogenic transcription factor), resulting in an increasing in the myonuclei provided by satellite cells to damaged muscle tissue, that not only repair damaged muscle fibers, but also increase their ability to grow.

Detoxification of the Liver

Substances that help the liver to process fats, or lipids, are known as lipotropic, and the important lipotropics in human biochemistry are imositol, betaine, choline and methionine. They prevent fat from accumulating in the liver, and methionine is also useful in its effect of glutathione. This is a substance that helps the liver to neutralize toxins, such as excessive doses of acetaminophen, and its supplies are regulated by methionine.

Methionine and Autism

Research into autism is closely studying the Methionine/Glutathione Transsulfuration Pathway. This pathway is a very important biochemical means of detoxification, whereby toxins are methylated and then excreted. This pathway seems to be disrupted in autistic individuals.

Not only that, but disruption can lead to oxidative stress which results in many health problems. An example of this is the build-up of the oxidant homocysteine when there is insufficient Vitamin B6 to convert it into cysteine. This has been discussed previously, and is discussed again below.

Miscellaneous Benefits

Although research is in its infancy, it appears that AIDS sufferers also have decreased levels of methionine in their blood. It is believed that the process of AIDS could be linked to this, particularly the dementia that can occur as a result of the deterioration of the nervous system.

It is also hoped that it can help with some symptoms of Parkinson's disease, and pancreatitis. Initial research into this use of methionine has been very promising, as are studies into its use for urinary tract infections. It appears to operate like cranberry in this respect, preventing bacteria from attaching to the cell walls and multiplying in the urinary tract.

Methionine is believed to be essential for the formation of collagen, and for healthy pliable skin, hair, nails and other forms of connective tissue. For this reason it is often used as a supplement for the treatment of arthritis, although an excess should be avoided for reasons discussed above. S-Adenosylmethionine generates homocysteine during the biosynthesis of phosphatidylcholine, and this can cause cardiovascular problems.

So stick to the recommended doses when you use methionine as a supplement. Used properly, and according to instructions, it offers many health benefits, and can also be used to bulk up your muscle tissue and give increased energy when you need it most.

Dietary sources include fish, eggs, lentils, onions, garlic, meat, seeds, spinach and yoghurt. A good supplement would be from 800MG - 1000mg per day, and is best taken along with a B vitamin complex, or at least folic acid and vitamins B6 and B12, in order to prevent the increased generation of homocysteine.

Methionine also promotes the excretion of estrogen, so is a possible supplement for women on oral contraceptives that lower the production of this hormone. The elderly might also benefit from a supplement although, if taken for any specific condition, your health professional should be consulted first, as they should be for any supplement.

Nevertheless, methionine is a very useful supplement, and can be taken to prevent a large number of conditions. Research is continuing on its effect on AIDS patients, and Parkinson's, and it is hopeful that it will one day be recommended to help people suffering from these conditions.

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Possible Billions in Health Care Costs, why hasn’t the government stepped in?
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Date: June 26, 2007 02:58 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Possible Billions in Health Care Costs, why hasn’t the government stepped in?

With the ever growing and aging population in the United States, dietary supplements could save the nation $24 billion in Health care cost.

Calcium with Vitamin D – approximately 776,000 hospitalized for hip fractures over 5 years.

Folic acid – could prevent 600 babies a year from neural tube defects saving $344.7 million in 5 years. Over the child’s life time 1.4 billion saved.

Omega-3 fatty acids – reducing the occurrence of coronary heart disease (CHD) with only 1800MG each day consumed. Saving $3.2 billion. Approximately 374,301 hospitalizations and associated physician fees due to CHD possibly avoided.

Lutein with Zeaxanthin – by supplementing 6 – 10 mgs of lutein with Zeaxanthin we could save over $3.6 billion over 5 years. Approximately 190,927 individuals could avoid dependency because of loss of vision.



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Turmeric and Alzheimer’s Disease
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Date: May 10, 2007 12:38 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Turmeric and Alzheimer’s Disease

Turmeric and Alzheimer’s Disease

 

In India, Alzheimer’s disease is relatively uncommon. People over the age of 65 living in certain rural areas of India have a less than 1 percent (0.84) chance of developing the disease. In the larger cities and rural areas of India, the risk is just 2.4 percent.

Compare these findings to people over the age of 65 living in the United States. Again, depending on where we are living, our chances of developing Alzheimer’s disease range from a little under 5 percent to an astonishing 17 percent.

So what are people who are living in India doing that we aren’t doing here in the US to account for these dramatic differences? The answer seems to be curry, that zesty spice and staple of Indian foods. Research has shown that a compound in curry not only prevents changes in the brain that lead to Alzheimer’s disease; it actually reverses some of the damage already present.

 

Q. How can curry prevent these changes in the brain? Isn’t that a lot to expect from a spice?

A. Evidently, it’s not too much to expect from this spice. Curry comes from the turmeric plant – Curcuma longa is the plant’s official name. Curcumin, a plant compound in turmeric, is the source of curry’s instantly recognizable bright yellow pigment. When it comes to the scientific research of Curcuma longa, the terms curcumin and turmeric are both used. Both refer to the same thing- tumeric extract.

There have been more than 1300 studies on tumeric and its health benefits for humans. Research has shown tumeric is able to help the body get rid of cancer-causing toxins. Turmeric also blocks estrogen receptors and enzymes that promote cancer. And it’s been found to stop the growth of new blood vessels in cancerous tumors – an important factor in keeping cancer from getting larger and spreading throughout the body.

But one of turmeric’s most exciting health benefits is its ability to reduce, prevent, and stop inflammation. While inflammation is a normal and needed response to injury or disease, chronic inflammation can cause damage to tissues. And researchers are now finding inflammation plays a huge role in Alzheimer’s disease.

 

Q. I’ve always heard that Alzheimer’s disease was caused by complex growths in the brain called plaques and tangles. How can simple inflammation cause such a devastating disease?

A. You are right. Plaques and tangles are indeed the hallmarks of Alzheimer’s disease. But researchers looking at the brain damage caused by Alzheimer’s have always noted the presence of inflammation wherever plaques and tangles form. In the past, this inflammation was thought to be simply a consequence of Alzheimer’s disease. Now scientists believe the inflammation itself starts a chain reaction ultimately contributing to the development of Alzheimer’s disease.

` When cells in the brain are disrupted by inflammation, amyloid, and a protein normally found in the brain, beings to act chaotically. This chaos results in the creation of beta-amyloid, protein that is toxic to cells in the brain. Sticky deposits of beta0amyloid build up and collect around the cells, making dense clumps or plaques. Because the brain can’t break the plaques down and get rid of them, they stay right where they are and slowly accumulate.

Tangles result when long protein fibers that act like scaffolding for brain cells begin to twist and tangle. The cell is damaged and eventually dies. But the tangled proteins remain in the brain even after the dead neuron has been cleared away. And inflammation might be the culprit causing the long protein fibers to start tangling.

The consequence of these abnormalities of protein in the brain is more than the cell death they cause. They also act as roadblocks interfering with electrochemical messengers being shot from cell to cell. Therefore, the remaining healthy cells’ activity is diminished as well.

Research of identical twins has repeatedly shown that if one twin has Alzheimer’s disease, the other has a 60% chance of developing the disease, too. Scientists from the Karolinska Institute in Stockholm, Sweden, looked at information from 20,000 twins collected in the 1960s and found 109 pairs of siblings where only one twin had been diagnosed with Alzheimer’s. When the Swedish researchers analyzed data about the twin’s health, they found the twin with Alzheimer’s disease almost always had chronic gum disease. While bleeding gums are definitely not he cause of Alzheimer’s disease, the inflammation that plays a large part of chronic gum disease may signal an inflammatory process stuck in overdrive.

In fact, the inflammatory process might occur years before the onset of Alzheimer’s, and be the result of any number of infections people can contract. That’s why current research is searching for ways to protect brain cells from inflammation. And why some countries have low rates of Alzheimer’s disease, like India.

 

Q. Why curry? Couldn’t other lifestyle difference account for the low rates of Alzheimer’s disease in India?

A. That’s a good question. When researchers begin studying a disease, like Alzheimer’s, they look for trends to help them determine how and why the disease occurs. For example, we all now know the connection between cigarettes smoking and long cancer. But, it wasn’t until the 1930’s that doctors noticed the trend fro cigarette smokers to have more lung cancer than people who didn’t smoke.

So it has been with researchers studying Alzheimer’s disease. They know Alzheimer’s disease has an important connection to inflammation. They also know turmeric reduces inflammation. And when researchers noticed these trends – that people in India eat high amounts of curry from turmeric and have very little Alzheimer’s disease – they began to theorize that turmeric might be able to prevent or even treat the illness. And the research they designed around these trends has unequivocally found turmeric to be on common denominator.

 

Q. What have the turmeric studies shown so far?

A. Simply amazing findings are coming from curry research. Not only does turmeric slow down cancer growth, it’s also been found to correct the cystic fibrosis defect in mice, help prevent the onset of alcoholic liver disease, and may slow down other serious brain diseases like multiple sclerosis.

Researchers from the University of California Los Angeles (UCLA) studying turmeric have found it to be more effective than the drugs currently being investigated for Alzheimer’s disease treatment and prevention. The researchers have discovered the actual structure and shape of turmeric allows it to penetrate the blood-brain barrier effectively and bind to beta amyloid that’s already built up in the neurons. Turmeric helps maintain healthy brain cellular metabolism, helps the cells repair themselves, and keeps the cells connected to each other. In other words, turmeric helps brain cells stay healthy.

And now the UCLA Alzheimer’s Disease Research Center (ADRC) is using turmeric in clinical trials and studying the effect of this powerful spice in patients diagnosed with this devastating disease. Clinical trials are the gold standard of medical research. But it’s rare in Alzheimer’s disease. And it’s even more rare when all-natural herbs and spices like turmeric are used in hopes the positive benefits will be discovered. The head of the UCLA’s research team was recently interviewed and stated that setting out to hopefully prove turmeric’s ability to prevent and treat Alzheimer’s disease was “tremendously exciting.”

 

Q. I recently read that one of the non-steroidal anti-inflammatory drugs (NSAID) was found to prevent Alzheimer’s disease. Is this true?

A. Scientists recently studied ibuprofen, one of the NSAIDs investigated for Alzheimer’s disease Prevention. Ibuprofen belongs to a family of drugs that includes naproxen, indomethacin, nabumetone, and several others. These drugs are used most often to get rid of headaches, mild arthritis, and other kinds of pain and inflammation.

In the studies, the average dose of ibuprofen was 800MG a day. Patients took the product for two years. While the results suggested that ibuprofen might reduce the risk of developing Alzheimer’s, ibuprofen’s side effects are too harmful to be a valid lifelong prevent aid treatment. Ibuprofen, like other NSAIDs, can cause gastrointestinal bleeding when used at high dosages over a long period of time. Long term use of ibuprofen can also lead to analgesic nephropathy, a kind of kidney damage caused by NSAIDs.

As we discussed earlier, turmeric appears to block and break up brain plaques that cause the disease and helps reverse some of the damage already present. Ibuprofen does not provide any protection against free radical damage. No anti-inflammatory medicine can do this.

 

Q. If I eat curry will I be protected against Alzheimer’s disease? There aren’t many foods or recipes I make that require curry, do I need to eat it every day? And how much do I need?

A. If you enjoy Indian cuisine, by all means, enjoy these delicious foods. You’ll benefit your brain and your appetite. But you make a good point, American meals rarely contain curry. That’s why supplements that contain extracts are suddenly quite popular. In fact, there are numerous turmeric/curcumin supplements on the market today.

But like all nutritional supplements, some turmeric supplements are superior to others. You need to read their labels to make sure the turmeric extract you are buying will provide the protection you need. Look for high-potency turmeric extract from turmeric (Curcuma longa) rhizome. And make sure the extract is standardized to contain 90% curcuminoids, the active ingredient in turmeric responsible for the positive research findings.

 

Conclusion

Researchers once thought that preventing for Alzheimer’s disease would elude them for decades. In fact, several scientists privately speculated the disease might never be ameliorated. They thought the origin of the disease was too complex and the symptoms of the disease were too profound.

That’s why ongoing research on turmeric is so exciting. A safe, natural, and effective way to protect against Alzheimer’s disease almost seems too good to be true. But, the nation of India and its low incidence of Alzheimer’s disease are proof these are not just fluke findings – making turmeric extract a supplement to remember.

 



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CHOLESTEROL RESCUE - Maintain Your Cholesterol Wellness
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Date: June 29, 2005 01:48 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: CHOLESTEROL RESCUE - Maintain Your Cholesterol Wellness

CHOLESTEROL RESCUE

You live in a fat-drenched, fast food world, propped up by diets loaded with processed foods that stimulate your body to create excess bad cholesterol – or low-density lipoproteins (LDL). Your busy life is full of stress, and devoid of time for proper exercise. There are three ways to deal with cholesterol in the body, but a seemingly infinite number of lifestyle and hereditary elements that affect LDL levels. Is it any wonder you find yourself in danger of developing unwanted cholesterol levels? Source Naturals is devoted to helping you. So we developed CHOLESTEROL RESCUE as a comprehensive solution to help you keep cholesterol levels in the normal range. CHOLESTEROL RESCUE uses only natural ingredients, clinically researched to effectively maintain healthy cholesterol levels. It is scientifically formulated with the triple action of three ingredients that target the ways you can deal with your cholesterol concerns; combining the naturally occurring polymethoxylated flavone (PMF) and tocotrienol action of Sytrinol™ with the action of plant sterols. Research suggests that daily consumption of 800 mg of plant sterols, taken with food in two divided doses as part of a diet low in saturated fat and cholesterol, may reduce the risk of coronary heart disease. Source Naturals offers CHOLESTEROL RESCUE as part of our ongoing commitment to providing you with high quality natural supplements to support your healthy lifestyle.

Cholesterol & Your Body

On average, humans ingest approximately 300mg of cholesterol per day. Though an important part of a healthy body, a high level of cholesterol in the blood might be out of the normal range. Cholesterol is transported in your system by lipoproteins. There are two kinds of lipoproteins in your body, but the low-density lipoproteins, or LDL, are the major factors in developing unwanted cholesterol levels. If there are high levels of LDL circulating in your bloodstream, it can undergo oxidation by free radicals in the artery walls, which can then become trapped as imbalanced deposits. These deposits can build up, reducing critical blood-flow. CHOLESTEROL RESCUE has been specially developed to reduce LDL levels using two different methods: inhibiting the synthesis of cholesterol in the liver, and reducing the absorption of dietary cholesterol.

The Plant Sterol Effect

Sterols are an essential component of the cell membrane, and are produced by both plants and humans. While the most common sterol produced in humans is cholesterol, plants produce phytosterols, or plant sterols. Using a complex compound of plant sterols similar to cholesterol with only slight molecular differences, CHOLESTEROL RESCUE has been formulated to balance the amount of dietary cholesterol your body absorbs.

Plant sterols have long been known to inhibit the uptake of both dietary and bile-produced cholesterol in the intestines. The most plausible theory behind this is that, because of the similarity between plant sterols and cholesterol, the body cannot properly distinguish between the two during the absorption process, thereby displacing the uptake of cholesterol into your system. Research suggests that daily consumption of 800MG of plant sterols, taken with food in two divided doses as part of a diet low in saturated fat and cholesterol, may reduce the risk of coronary heart disease.

Sytrinol™ For Heart Health

CHOLESTEROL RESCUE also contains SYTRINOL™, a proven natural alternative for maintaining cholesterol wellness. The patented blend of citrus polymethoxylated flavones (PMFs) and tocotrienols has been clinically shown to promote cardiovascular health by supporting normal cholesterol production by your liver, helping balance triglyceride production, and providing powerful antioxidant protection. The PMFs promote normal cholesterol levels by inhibiting both the production of cholesterol precursors, such as cholesteryl esters, and the activity of HMG CoA Reductase, an enzyme that synthesizes cholesterol in the liver. These PMFs can also balance the body’s production of triglycerides by inhibiting your liver’s triglyceride producing enzyme, diacylglycerol acetyltransferase. Tocotrienols help break down cholesterol building blocks, interfere with cholesterol production, and provide critical antioxidant protection. Because cholesterol becomes problematic when oxidized, the powerful antioxidant action of tocotrienols can help prevent the conditions that may affect your cardiovascular circulation.

Spearheading the Wellness Revolution in Cholesterol Defense

With so many ways to develop undesirable cholesterol levels in your body, you need to be proactive in maintaining your good health. In our on-going dedication to your wellness, and a commitment to delivering the benefits of our high quality supplements to the natural products marketplace, Source Naturals has produced a scientifically formulated blend of three effective ingredients in fighting unwanted cholesterol. Combining a comprehensive formula of allnatural components, clinically researched for promoting cardiovascular health, CHOLESTEROL RESCUE is available now at your local health food store.

References
Guthrie N, Kurowska EM. Anticancer and Cholesterol-lowering activities of citrus flavonoids. Handbook of Nutraceuticals and Functional Foods. (Wildman, R.E.C., ed), CRC Press, Boca Raton, FL. 2001. 113-126. Packer L, Weber SU, Rimbach G. Molecular aspects of alphatocotrienol antioxidant action on cell signaling. Symposium: Molecular Mechanisms of Protective Effects of Vitamin E in Atherosclerosis. American Society for Nutritional Sciences. 2001. 131:369S-373S. Hicks KB, Moreau RA. Phytosterols and phytostanols: functional food cholesterol busters. Food Technology. 2001. 55:63-67. Middleton Jr E, Kandaswami C, Theoharides TC. The effect of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Review. 2000. 52:673-751. Child P, Kuksis A. Critical role of ring structure in the differential uptake of cholesterol and plant sterols by membrane preparations in vitro. Journal of Lipid Research. 1983. 24: 1196-1209



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