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Mega Mind - re-align your body systems ... Darrell Miller 6/3/05
COENZYME Q10 - Transforming food into energy Darrell Miller 6/1/05
Go Deep to the Underlying Cause of Symptoms* Darrell Miller 5/31/05
Re: Acetyl-L-Carnitine - Anti-Aging Brain Nutrient ... Darrell Miller 5/31/05



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Mega Mind - re-align your body systems ...
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Date: June 03, 2005 05:24 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Mega Mind - re-align your body systems ...

MegaMind

Aging and nutritional imbalances can disrupt the multiple body systems that affect healthy brain function. The result: cognitive symptoms* such as forgetfulness, inability to focus, and mental fatigue. MegaMind™ is a Bio-Aligned Formula™ that helps align multiple systems: neurotransmitter production, antioxidant defense, energy generation, circulation, and myelin sheath generation. Complementary Formulations Source Naturals can help keep your mind sharp and alert. Use MENTAL EDGE® Bio-Aligned Formula for foundational support, or MegaMind, when memory symptoms* are severe. HIGHER MINDTM is an additional Bio-Aligned choice. Take these formulas alone or as the core of a program that includes additional ingredients such as DHA (NEUROMINS®), GINKGO-24™, PHOSPHATIDYL SERINE, VINCAMINE, and VINPOCETINE.

In today’s complex world, we are bombarded with information. Our ability to process this massive input depends on how well we nourish the multiple body systems related to brain health. In addition, normal aging is associated with impairment of certain mental functions, according to the National Institute on Aging. The brain undergoes changes including functional decline in neurons important to learning, memory, planning, and other complex mental activities, as well as increased oxidative stress. In healthy people, these changes may result in varying degrees of age-related memory decline. Source Naturals can help, with a full line of cognitive support products.

Mental Edge®: Bio-Aligned Formula

MENTAL EDGE is a literal multivitamin for your brain. MENTAL EDGE supports production of neurotransmitters including acetylcholine, antioxidant defense, energy generation, stress response and myelin sheath generation. It features nutrients needed for production of neurotransmitters— chemical messengers in the brain’s communication system. One of the most important of these is acetylcholine, which is necessary for memory and muscle movement. MENTAL EDGE also contains antioxidants—vitamin C, ginkgo, DMAE, and zinc—to protect the neuron cell membranes where electrical signaling takes place. Adaptogenic herbs provide the brain with support and energy to deal with environmental stress. Energy-generating ingredients such as ginkgo and B-vitamins are vital to the high-powered functioning of your brain. Vitamins B-5 and B-12 are also important for formation of myelin, a substance that forms a protective insulating cover around certain nerve fibers and increases nerve impulse conduction.

MegaMind™: Bio-Aligned Formula When memory symptoms* are severe, you may need a formula with extraordinary cognitive support. MegaMind addresses many of the same body systems as MENTAL EDGE, but does so with megadoses of brain nutrients, such as L-pyroglutamic acid and vitamin B-1 for neurotransmitter production. It also adds bacopa and the inhibitory neurotransmitter GABA to support neurotransmitter production, and higher potency vitamin B-12 for myelin sheath generation. Like MENTAL EDGE, MegaMind supports energy generation and antioxidant defense. MegaMind augments basic support for the brain’s immense energy requirements with higher potency vitamin B-1, and with one of nutritional science’s most advanced, high-tech nutrients, alpha-lipoic acid. Lipoic acid is also an antioxidant, as are gotu kola and grape seed. MegaMind also supports circulation with ginkgo and gotu kola.

Mega Mind: Bio-Aligned Formula HIGHER MIND is another multi-system support formula, which features phosphatidyl serine, a structural component of nerve cell membranes, and the botanical vinpocetine. HIGHER MIND nourishes neurotransmitter production, cell membrane stability, energy generation, antioxidant defense and myelin sheath generation.

Neurotransmitter Production: Bacopa, GABA, L-Glutamine, L-Pyroglutamic Acid, Taurine, N-Acetyl L-Tyrosine, Manganese, Vitamins B-1 & B-6

Acetylcholine Production: Acetyl L-Carnitine, DMAE, Gotu Kola, L-Pyroglutamic Acid, Vitamin B-5

Myelin Sheath Generation: Vitamins B-5 & B-12

Energy Metabolism: Acetyl L-Carnitine, Ginkgo Biloba, L-Glutamine, alpha-Lipoic Acid, Calcium, Magnesium, Manganese, Potassium, Zinc, Vitamins B-1, B-2, B-3, B-5, B-6 & B-12, Biotin,Folic Acid

Circulation: Ginkgo Biloba, Gotu Kola

Antioxidant Defense: DMAE, Ginkgo Biloba, Gotu Kola, Grape Seed, alpha-Lipoic Acid, Zinc, Vitamin C

Complementary Cognitive Support Products

For additional support, you can supplement Source Naturals Bio-Aligned formulas with these single ingredient products: ACETYL L-CARNITINE and DMAE are both important to the synthesis of acetylcholine, a key neurotransmitter associated with higher cognitive functions, such as learning and memory. DHA (NEUROMINS®) is an omega-3 fatty acid that plays a significant role in cerebral development, especially during fetal development and infancy. GINKGO is renowned for promoting blood flow to the brain. Source Naturals GINKGO-24™ is a standardized concentration of Ginkgo biloba leaves, yielding 24% ginkgo flavone glycosides and 6% terpenes (the key constituents). PHOSPHATIDYL SERINE is necessary for the health of nerve cell membranes, where electrical signaling takes place. These membranes are critical to information processing. VINCAMINE, an alkaloid obtained from the periwinkle plant, supports cerebral metabolism by promoting blood flow and oxygen and glucose utilization. VINPOCETINE is a derivative of vincamine, shown in research studies to improve cognitive performance and alleviate the short-term memory loss that may accompany stress or aging.

Lifestyle Tips for Cognitive Health: A Strategy for Wellness SM

Eat Well: Recent research suggests that diets rich in beta-carotene and vitamins C and E help reduce memory problems, probably by lessening oxidative stress. And new animal research at the University of Toronto found that a high-fat diet slowed the ability of rats to learn new tasks. Use Your Brain: Learn a foreign language or new hobby, do crossword puzzles, read books, and cut back on TV. Scientists at Case Western found that people who were less mentally active in middle age were three times more likely to experience memory decline as they got older. Stay Active: Vigorous walking can improve mental processes in aging individuals, according to research. Aerobic exercise increases oxygenation and blood flow to the brain, resulting in improved memory, organization, and the ability to juggle intellectual tasks. Manage Stress: Longterm anxiety or depression can make a person more forgetful. Try to regulate stress, increase social contacts, and, if necessary, seek professional help. Get Organized: Make the most of your cognitive abilities, through the use of memory aids such as “to-do” lists, notes, or calendars.

References
Braquet, P. Ginkgolides-Chemistry, Biol., 1988. FAO/WHO Expert Committee (1994). Food and Nutrition Paper No. 57. FAO: Rome. 49-55. Heiss, W.D., et al. (1993). Annals N.Y. Acad. Sci. 695: 327-31. Passeri, M., et al. (1990). Int. J. Clin. Pharm. Res. X(1/2): 75-79. Simopoulos, Artemis P. (1991). Am J Clin Nutr: 54. 438-63. Vorberg, G., M.D. Clinical Trials Journal 22.2 (1985): 149-57.



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COENZYME Q10 - Transforming food into energy
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Date: June 01, 2005 11:06 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: COENZYME Q10 - Transforming food into energy

Coenzyme Q10

It’s 3:30 p.m. and you feel irritable; you can’t seem to concentrate. You were so busy you skipped lunch. At last you bite into the sandwich that you were ready for 3 hours ago. By the time you have eaten half of it, energy is starting to flow through you. What happened? The answer to that question is both extremely complex and very simple. In essence, your body transformed the food into useable energy. CoQ10 is a crucial component of the primary energy generating cycle that takes place in each of the trillions of cells in our bodies. CoQ10 is essential for human life.

To transform that lunchtime sandwich into useable energy your body essentially has to burn it - just the way a car burns gasoline to drive its engine. This energy generating process takes place in structures called mitochondria - tiny power plants which are within every cell. Inside these energy generating stations, fats, sugars, and amino acids are transformed into ATP, an energy-rich molecule sometimes called the “energy currency” of the body.

Energy Generation Requires Nutrients

The body requires many nutrients in order to perform the complex biochemical processes that convert food into ATP “energy currency.” Some of these nutrients such as the B-vitamins are familiar to us. However, there are many other substances which are essential to this process. Coenzyme Q10 is one of these.

Functions of CoQ10

Several complex metabolic pathways are required in order for the body to transform that lunchtime sandwich into energy that you can feel and use. First glycolysis and the Krebs’ cycle break down large molecules of protein, carbohydrate and fat into smaller components. CoQ10 is a key enzyme in the Electron Transport Chain - the final stage in this extraordinary design. This pathway generates 90% of the ATP needed by the body from the food we eat. ATP provides the “energy currency” for the following crucial metabolic functions: 1) synthesis of cellular components including cholesterol and proteins (formed primarily by the liver), 2) nerve conduction (in the brain and peripheral nerves), and 3) energy for muscular contraction (of the heart and skeletal muscles). The Heart: The heart muscle (myocardium) consumes a tremendous amount of energy. Your heart beats over 100,000 times and pumps 1,000 gallons of blood each day! CoQ10 is necessary for the generation of the energy required by the heart. Numerous scientific studies have demonstrated that supplementation with this nutrient may support normal heart function. Its presence is necessary for cardiac performance during exercise as exemplified by criteria including: blood flow, oxygen utilization, contractility and exercise tolerance. In addition, CoQ10 may play a role in the regulation of blood pressure. The Gums: Since the 1970’s scientists have been researching the effects of CoQ10 on the health of the oral tissues. Although the mechanism of action is not known, research has established that CoQ10 has a profound ability to preserve and maintain the health of the gums. Antioxidant Properties: CoQ10 plays an additional vital role in our metabolism as a protector of lipids in cell membranes. Laboratory studies have also shown that CoQ10 is more efficient than vitamin E, beta carotene or lycopene in safeguarding LDL cholesterol from oxidation by peroxides. This process is important for maintaining the health of our blood vessels.

Energy Insurance

CoQ10 is needed in body tissues where energy production is critical, such as the liver, brain and muscles. Therefore we include CoQ10 in significant potencies in many of our premium formulas, such as Life Force Multiple™, Élan Vitàl™, Heart Science™, Liver Guard™, MenoBalance™, Higher Mind™, MegaMind™ and Wellness Multiple™. We also offer a combination of CoQ10 and Lipoic Acid (30 mg each), CoQ10 Sublingual (30 mg and 60 mg), 30 mg CoQ10 Softgels with Bioperine® and 30 mg CoQ10 NutraSpray™. Our single CoQ10 products are CoQ10 in 15 mg, 30 mg, 75 mg, 100 mg, and Ultra Potency 125 mg caps.

References
1) Folkers et al., BCACQ, Elsevier, 1977
2) Judy et al., BCACQ, Elsevier, 1984.
3) Kamikawa, T. et al., American Journal of Cardiology, Vol. 56, August 1, 1985, p. 247-250.
4) Nohara et al., Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, 1984.
5) Packer, L., Oxidative Stress and Aging, Birkhauser Verlad, 1995.
6) Stocker, et al., Proceedings of the National Academy of Sciences, Vol. 88, pp 1646-1650, March 1991.
7) Tortora, G. Principles of Human Anatomy, 4th Ed., Harper & Row, New York, 1986, p. 301.
8) Wilkinson and Arnold, Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, 1977.
9) Yamagami et al., Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, 1977.



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Go Deep to the Underlying Cause of Symptoms*
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Date: May 31, 2005 05:37 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Go Deep to the Underlying Cause of Symptoms*

Go Deep to the Underlying Cause of Symptoms*

Bio-Aligned Formulas Balance Your Body Systems

Source Naturals comprehensive Bio-Aligned Formulas go deep to address the root causes of nutritional symptoms*. Our expert formulators exhaustively review the latest scientific research on nutrition and health. Then they design scientifically based formulas that help bring alignment to your multiple, interdependent body systems. Only this in-depth formulation approach can bring you the most effective formulas possible.

Cardiovascular Symptoms*

Your heart function and circulation can be disrupted by factors including diet, stress, and free radicals. Bio-Aligned Formulas supply nutrients to meet the heart’s energy requirements, nutrients necessary for the maintenance of blood vessels, antioxidants to help control cholesterol oxidation, minerals to support normal electrical rhythms, vitamins for regulation of homocysteine levels, and fibers to help with the exertion of cholesterol. The following formulas help align these systems: CHOLES RESPONSE™, CHOLESTREX ®, HEART SCIENCE ™, and POLICOSANOL CHOLESTEROL COMPLEX ™.

Cognitive & Mood Symptoms*

Brain health can be affected by nutrition, lifestyle and environmental factors, leaving you susceptible to problems in memory, concentration, and perception. Bio-Aligned Formulas provide ingredients such as neurotransmitters for brain cell communication, phospholipids that are components of nerve cell membranes, nutrients to fuel the brain’s energy demands, and herbs for stress response. The following formulas help balance these underlying systems: ATTENTIVE CHILD™, CALM THOUGHTS ™ KAVA, HIGHER MIND ™, MegaMind ™, MENTAL EDGE®, NIGHT REST ™, POSITIVE THOUGHTS™, and VISUAL EYES™.

  • *The term symptom as used in this literature refers to the effects of nutrient shortages or imbalances and is not related to the diagnosis, treatment, cure or prevention of any disease.
  • Digestive, Eliminative & Metabolic Symptoms* Without adequate nutrition, your liver can’t perform its critical functions: detoxification, metabolism, and conversion of vitamins into usable forms. Bio-Aligned Formulas provide antioxidants, herbs that detoxify and promote bile flow, ingredients for the liver’s energy needs, nutrients that support glucose metabolism and pancreatic activity, and digestive enzymes. The following formulas bring these systems into alignment: ESSENTIAL ENZYMES™, GLUCO-SCIENCE™, HERBAL RE:STORE™, and LIVER GUARD™.

    General Symptomatic Conditions*

    Daily well-being requires nutrition for your major body systems. While typical multiples supply just enough ingredients to meet minimum requirements, Bio-Aligned Formulas provide nutrients to support energy and liver function, heart-friendly botanicals, herbs that promote circulation to the brain, immune-supporting vitamins, minerals for your skeletal system, and antioxidants for general protection. These multiples bio-align your body systems: ÉLAN VITÀL™ MULTIPLE, and LIFE FORCE™ MULTIPLE.

    Immune Symptoms*

    Appropriate immune response is critical for seasonal health and wellness all year around—but it can be compromised by stress, lack of sleep, and poor diet. Bio-Aligned Formulas supply botanicals that modify histamine release, nutrients for the adrenals, clearing herbs, and antioxidants to defend white blood cells. The following formulas help bring these systems into balance: ALLERCETIN™, ALLER-RESPONSE™, CAT’S CLAW DEFENSE COMPLEX™, WELLNESS COLD & FLU™, WELLNESS COUGH SYRUP™, WELLNESS EARACHE™, WELLNESS FORMULA®, and WELLNESS MULTIPLE™.

    Joint, Bone, and Muscular Symptoms*

    Healthy joints, bones, and muscles require continuous nutrition. Bio-Aligned Formulas provide components of joint and connective tissue, bone-building minerals, soothing herbs, and nutrients that support muscular energy. The following formulas help align these systems: FIBRO RESPONSE™, GLUCOSAMEND™, MUSCLE MASS™, ULTRA-CAL NIGHT™, and ULTRA JOINT RESPONSE™.

    Men’s & Women’s Symptoms*

    The health of men and women can be impacted by diet, stress, and aging. Bio-Aligned Formulas provide phytoestrogens for hormonal balance, calming neurotransmitters, ingredients for metabolic support, and nutritional support for skin, hair, and nails. The following formulas help harmonize these systems: LUSTRE™, MALE RESPONSE™, MENOPAUSE MULTIPLE™, MONTHLY COMFORT™, MOOD BALANCE™, PROSTA RESPONSE™, SKIN ETERNAL PLUS™ and ULTRA BONE BALANCE™.

    Choose Your Bio-Aligned Formula

    In a world of dizzying consumer choices, shopping for the right supplement can leave you confused and frustrated. And since few companies disclose the rationale behind their formulas, it’s hard to make an informed choice. The best place to start is at your local health food store. The natural foods industry is unique in its dedication to holistic health, self-care and consumer education. And the Source Naturals Bio-Aligned Formulas Chart Book—now available at participating health food stores as well as online—is an invaluable tool. The Chart Book helps you pick the formula that is appropriate for your nutritional symptoms* by explaining how each formula supports specific, interdependent body systems. Source Naturals Bio-Aligned Formulas are expertly designed using groundbreaking nutrients, clinically substantiated potency levels, cofactors that facilitate the action of key ingredients, bioavailable forms, and effective delivery systems. Together, these ingredients can help bring you the power of Bio-Alignment.



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    TopPreviousNext

    Date: May 31, 2005 04:39 PM
    Author: Darrell Miller (dm@vitanetonline.com)

    Acetyl-L-carnitine is truly a mind-body nutrient. It helps synthesize acetylcholine, the brain's principal neurotransmitter responsible for learning and memory. And it is a more bioavailable form of L-carnitine, an amino acid derivative that performs the vital function of transporting longchain fatty acids into the cellular mitochondria where they are oxidized to generate metabolic energy. Supplemental acetyl-L-carnitine supports the activity of brain cells that depend on acetylcholine. It can also reduce the metabolic waste products that damage cells over time. As one of the most important nutrients to help slow the aging process, acetyl-L-carnitine is at the heart of Source Naturals' commitment to empower people to take charge of their own health.

    Acetylcholine is the brain's principal neurochemical of thought. Neurons need it to communicate with each other, especially to create and recall memories. Acetylcholine is also involved in muscular coordination. At neuromuscular junctions throughout the body, it tells muscles when to contract. But the efficiency of cells that use acetylcholine naturally declines with age, partly because of decreased activity of the enzyme that synthesizes this neurotransmitter.

    Neurotransmitter Production

    Acetylcholine is created when the enzyme choline acetyl transferase (CAT) attaches an acetyl group to a choline molecule. CAT activity is heightened by acetyl-L-carnitine, which donates its acetyl group. Acetyl-L-carnitine is made in small amounts naturally in the body, but its production begins to decline in midlife. In well-controlled human studies, supplemental acetyl-L-carnitine slowed the progress of mental decline by notably improving attention and memory. When supplemental acetyl-L-carnitine was combined with lipoic acid (a powerful natural antioxidant), significant improvement in memory was seen in animals. Researchers said that together the two chemicals "tune up" the mitochondria, the energy-producing organelles that power all cells. Mitochondrial decay is believed to be the primary reason for age-related deterioration of cognitive function and energy levels.

    Cellular Energy and Protection

    As the active form of L-carnitine, acetyl L-carnitine efficiently transports long-chain fatty acids into the mitochondria where they are converted into ATP (adenosine triphosphate), the energy molecule. Animal studies suggest that supplemental acetyl L-carnitine has a positive effect on energy generation as well as on the structural integrity of aging mitochondria. By supporting fatty acid metabolism, acetyl L-carnitine also helps reduce lipofuscin, a metabolic waste product composed of damaged proteins and rancid fats. The brown "liver spots" on some elderly hands are composed of this aging pigment that gradually builds up in cells of the heart, liver, brain, and lens of the eye.

    Muscle Performance

    Ninety-five percent of the body's carnitine is found in muscle cells, especially in the heart where mitochondria comprise nearly 50% of a cell's volume. During prolonged exercise, muscles have a high demand for carnitine because fats can account for up to twothirds of the energy burned. L-carnitine supplements can increase exercise endurance and reduce fatigue. Acetyl L-carnitine is also a key nutrient in Source Naturals' legendary neuroceutical formulas MegaMind™ and HIGHER MIND™. And because acetyl L-carnitine also generates the basic energy that affects all biological and mental processes, this mind-body nutrient is one of the few nutritional compounds with such a broad range of action in maintaining youthful functioning. Source Naturals ACETYL L-CARNITINE is therefore an essential part of a smart strategy to live well, age well.

    References

    Carta A. and M. Calvani. Acetyl-L-carnitine: a drug able to slow the progress of Alzheimer's disease? Ann NY Acad Sci 1991; 640: 228-232. Hagen T.M. et al. August 4, 1998. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc Natl Acad Sci USA 95(16):9562-6. Liu J. et al. February 19, 2002. Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. PNAS 99(4):1876-81. Spagnoli A.U. et al. 1991. Long-term acetyl-L-carnitine treatment in Alzheimer’s disease. Neurology. 41(11):1726-1732.



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