Search Term: " R-Lipoic "
Liver Protection With Lipoic Acid and R-Lipoic Acid
May 05, 2011 03:42 PM
Early biochemistry studies pioneered by Linus Pauling associated R-Lipoic acid with orthomolecular medicine in that proponents argued that it biological roles provide protection against diseases. Succeeding research in the latter half of the 20th century supported its status as an essential nutrient, but more recent studies proved that all it is produced in vivo by almost all mammals, including human beings. In the past few years Lipoic acid has been strongly linked to glutathione as its supplementation appears to raise levels of endogenous glutathione.
Strengthens Antioxidant Defense
Lipoic acid is believed to raise the antioxidant capacity of the human body. Its biological roles benefits all cells, most notably hepatocytes, the cells that make up a significant fraction of the liver. For one, it affects productions of glutathione throughout the body. Glutathione is tripeptide that protects cells from the damage caused by reactive oxygen species, such as free radicals. Furthermore, it is a major transport of toxins found in the systemic circulation, facilitating their excretion through the urine.
R-Lipoic acid has been observed to be the form of Lipoic acid that is capable of activating nuclear factor erythroid-derived-2-like 2, commonly abbreviated as NFE2L2, the protein that binds to DNA sequences responsible for regulating the antioxidant defense of the human body. Proponents believe that oral intake of R-Lipoic acid produces more visible results than its racemic counterparts.
Displays Higher Bioavailability
Research on Lipoic acid is one of the most advanced, starting in the 20th century and spanning over 5 decades. It is widely accepted that the forms available in the market are not bioequivalent. Most of the studies in the 1950’s utilize the enantiomer S-Lipoic acid and R/S-Lipoic acid race mixture because they were cheaper to produce. Recent developments in chiral chemistry have increasing allowed for large-scale productions of R-Lipoic acid.
Many scientists today believe that R-Lipoic acid is superior to racemic forms. Its rate and extent in availability after oral administration has been noted to be far better, and thus its efficacy is expected to be more remarkable. It is postulated that its higher bioavailability allows it to effective fill the roles of endogenous lipoic acid, not to mention manage to influence the master regulator of antioxidants.
Shows Vitamin-like Properties
The popularity of R-Lipoic acid lies in vitamin-like properties. Researchers are particularly enthusiastic about its purported benefits on human health, though more studies are needed. It is one of the organic compounds needed for enzyme function just like vitamins, and supplementation is believed to produce preventative benefits against diseases. Its pervasive roles at the cellular level enable it to affect energy metabolism, leading to healthy weight loss.
NEW PRODUCT ANNOUNCEMENT
July 05, 2005 06:29 PM
The Most Comprehensive Antioxidant Formula Available!
Four tablets contain: Vitamin A (as beta-carotene 8,500 IU & palmitate 4,000 IU) 12,500 IU
gamma-Vitamin E Complex 500 mg
Quercetin 100 mg
Life Force - The Energy Activator
June 29, 2005 10:35 AM
Don’t Be Confused About Multiples – Get the Top-Ranked Multiple That Scores 100%
We can help you decide how to pick the most advanced daily multiple for your wellness. Listen to the experts. Source Naturals LIFE FORCE MULTIPLE was honored as a leading formula in an independent scientific analysis of 500 multiples, ranking higher than any other national brand. Lyle MacWilliam, author of the Comparative Guide to Nutritional Supplements (ide.com) ranked multiples based on criteria developed from the published recommendations of the most renowned nutritional authorities: Phyllis Balch, C.N.C.; Michael Colgan, Ph.D.; Earl Mindell, Ph.D.; Michael Murray, N.D.; Richard Passwater, Ph.D.; Ray Strand, M.D.; and Julian Whitaker, M.D. Source Naturals’ success in this rigorous scientific analysis reflects our Bio-Aligned™ formulation method. LIFE FORCE goes deep to the underlying cause of health imbalances by supporting multiple body systems. And now, based on the latest scientific research, we have improved the formula by adding even more antioxidants and other cutting-edge ingredients. According to Lyle MacWilliam, “Source Naturals made a top ranked multiple even better!” And based on Lyle’s analysis of the new formula, LIFE FORCE is now the highest rated multiple of any evaluated in the current edition of this guide, scoring a 100% rating.
Bio-Align™ Yourself with Life Force
LIFE FORCE MULTIPLE was chosen as one of America’s most elite and comprehensive multiples, as reported in the Comparative Guide to Dietary Supplements by Lyle MacWilliam, 3rd ed. LIFE FORCE received this acknowledgement by nutrition experts because it is uniquely effective. This Bio-Aligned Formula™ goes beyond ordinary multiples that simply replace nutrients missing from the diet. LIFE FORCE provides key organ-specific nutrients to support your body’s energy generation, heart, brain, immune system, musculoskeletal system, skin, liver, eyes, and more. When all your body systems function in harmony, everything in life comes together. Your mood is positive, your mind is clear, you’ve got energy in your step—that’s your LIFE FORCE working for you.
Get Ahead with Activated Energy and a Healthy Metabolism
Your metabolism determines how much you weigh, how energetic you feel, and the effective functioning of all your systems. LIFE FORCE is a rarity – a unique multiple containing an incredible number of nutrients at the potency levels that truly support your healthy metabolic function. For example, it contains coenzyme Q10, which plays a crucial role in cellular energy production. CoQ10 is a vital intermediate in the electron transport chain, one of the body’s energy production cycles, which converts glucose, or blood sugar, into ATP (Adenosine Triphosphate), a high energy molecule that is the body’s “energy currency.” LIFE FORCE also supplies alpha-lipoic acid and the potent R-Lipoic acid form of lipoic acid, which are both referred to as the universal antioxidants and important intermediaries in the Krebs cycle, another energy production cycle.
LIFE FORCE also contains tyrosine and iodine, both precursors to thyroid hormones. These hormones regulate key metabolic functions like heart rate, digestive function, weight management and energy levels. No discussion of metabolism would be complete without mentioning the B vitamins and their coenzymated forms, such as thiamin cocarboxylase, riboflavin mononucleotide, and the methylcobalamin form of vitamin B- 12. These critical vitamins and their immediately bioavailable coenzymated forms are formulated to play critical roles in thousands of enzyme reactions that promote carbohydrate metabolism, energy production, and the mental functions that invigorate and activate you as you move through your busy days. And now green tea extract with EGCG (Epigallocatechin Gallate) has been added to the formula for added metabolic support.
Protect Your Heart and Circulatory System
The amazing muscular organ that is your heart beats more than 100,000 times a day, 365 days a year, promoting vitality and alertness by constantly oxygenating our tissues. LIFE FORCE supports your cardiovascular system with antioxidant coenzyme Q10, which helps support heart muscle metabolism. LIFE FORCE also contains the minerals potassium and magnesium, electrolytes vital for healthy heartbeat and heart function, and the herb hawthorn, a rich source of antioxidant flavonoids, which has traditionally been used as a heart tonic. LIFE FORCE also supplies vitamins B-6, B-12 and folic acid to help maintain healthy homocysteine levels and vitamin K to support healthy circulation. Unlike common multiples, it supports cholesterol wellness, circulatory health and antioxidant cardiovascular protection, with both the typical d-alpha form of vitamin E but and the more potent and effective gamma-tocopherol and similarly structured tocotrienols.
Skin and Musculoskeletal Support
LIFE FORCE furnishes nutrients to build healthy bones, muscles and skin. We all know that calcium and magnesium are crucial for bone health, but many people don't know that there are a variety of nutritional cofactors that help build bone, such as vitamin D (which enhances calcium absorption and utilization), boron, manganese and copper. LIFE FORCE also supplies vitamin C and copper, necessary nutrients for collagen production (collagen is a key constituent of connective tissue in joints, skin and other areas), and the cutting-edge nutrient methylsulfonylmethane (MSM), an assimilable form of the mineral sulfur, used by the body to build and maintain connective tissues, including joint cartilage, hair, skin and nails. Additional nutraceuticals to support healthy skin include DMAE bitartrate, CoQ10, and alpha lipoic acid. LIFE FORCE also now includes rutin, quercetin, green tea extract and 65% more turmeric extract for your joint comfort.
Brain and Nerves Nutrition
The hectic pace and constant demands of life can keep our pulse racing, our nerves jangling and our temples throbbing. Our nervous systems are crying out, “Help!” LIFE FORCE provides that help. LIFE FORCE supplies the most highly bioavailable and bioactive forms of the amino acid tyrosine – the N-acetyl form and the acetyl-L form. Tyrosine is an important precursor to epinephrine and norepinephrine (collectively known as the catecholamines), which helps you respond to stress. It also contains high doses of vitamins C and B-6, required by the adrenal glands to produce the catecholamines. In addition, LIFE FORCE delivers the full spectrum of B vitamins, all important for healthy nervous system function. Now LIFE FORCE also contains a more bio-available form of tyrosine, acetyl-L-Tyrosine. And LIFE FORCE contains Neuroceutical® nutrients that support healthy brain function by furnishing DMAE and choline. Both are precursors to the important neurotransmitter acetylcholine and are important for memory focus and muscular movement. Choline is also a precursor to phosphatidylcholine, an important constituent of the cellular membranes that surround and protect our brain cells. In addition, LIFE FORCE contains the renowned herb Ginkgo biloba and now even more grape seed extract, both effective antioxidants that can prevent lipid peroxidation, which is critically important for the high amounts of fatty tissue in the brain. LIFE FORCE—good food for the brain.
LIFE FORCE MULTIPLE supports your immune system, so you can feel your best through the seasons. LIFE FORCE contains the immunosupportive nutrient vitamin A, which fosters cell-mediated immunity and protects the epithelial linings of the respiratory and digestive tracts. Two forms of vitamin A are supplied: preformed vitamin A and its precursor, the potent antioxidant betacarotene. Other immuno-supportive nutrients in LIFE FORCE include vitamin B-6, vitamin C and zinc, which is fundamental for proper functioning of our T-cells, the “seek and destroy” cells of our immune system. LIFE FORCE also now includes 40% more lipoic acid, including the highly bioavailable alpha and R-isomer forms. Lipoic acid along with the B vitamins and CoQ10 promote building the energy reserves needed when the immune system needs to kick into high gear.
Powerful Liver Support
Your liver is responsible for converting many nutrients into their metabolically active forms before your body can use them. After activation, these nutrients travel through the blood stream to target organs where they perform their metabolic functions. Not only does the liver activate nutrients, but it also plays a crucial role in a variety of other metabolic functions, from fat digestion and cholesterol production to blood sugar regulation to the processing and elimination of toxins, an important role in today’s increasingly polluted world. For all these reasons, nourishing the liver is crucial. And LIFE FORCE does just that. LIFE FORCE contains alpha-lipoic acid, turmeric, silymarin and N-acetyl cysteine (NAC) – all potent antioxidants that support healthy liver function. NAC and alpha-lipoic acid both help produce glutathione, one of the liver’s primary detoxifying molecules. Silymarin, the active flavonoid complex of the herb milk thistle, as well as coenzyme Q10, have been shown in vitro to inhibit lipid peroxidation of cell membranes. Turmeric extract promotes bile flow and is a rich source of the antioxidant, curcumin. LIFE FORCE also contains choline and inositol, vitamin- like molecules which act as lipotropics, unique substances that prevent the deposition of fat in the liver. Since the liver is naturally high in fats, LIFE FORCE is one of the only multiples that contains the fat-soluble form of vitamin C, ascorbyl palmitate, for antioxidant protection.
Complete Antioxidant Defense
Oxidative stress is the primary cause of accelerated aging. This and other forms of free radical damage are constantly threatening your body. Whether it is from pollution, ultraviolet light, food additives, or from other sources, it is more critical than ever to protect your body with antioxidants. LIFE FORCE contains 24 of the most powerful antioxidants known to science, including eight new antioxidants based on the latest research. It contains antioxidants that are water soluble, such as quercetin and rutin, and ones that are fat soluble, such as alpha-lipoic acid and lycopene. There are antioxidants that are especially protective of specific body systems, such as lutein to protect the macula in your eye, lycopene to protect your prostate gland, and tocotrienols to protect your arteries.
Cutting-Edge Vision Nutrition
The structure and functions of your eyes are very complex. LIFE FORCE contains nutrients to help support and maintain healthy eye tissue, which is particularly susceptible to oxidative stress from free radicals. To support your healthy macula, aqueous tissue and optical nerve signals, LIFE FORCE includes ingredients such as lutein, astaxanthin, beta carotene, bilberry, zinc, lipoic acid and quercetin.
Life Force Replenishes Essential Nutrients to Support Your Low Carb Lifestyle
LIFE FORCE contains optimal levels of many nutrients that might be deficient in low carb meals. Counting carbs can lead to restrictions of nutrient-dense foods, such as dairy products, grains, fruits and vegetables. LIFE FORCE contains many of the same protective antioxidants, vitamins and minerals as fruits and vegetables, including betacarotene, vitamin C, vitamin E, flavinols, magnesium and selenium. It also contains high levels of the same vitamins found in grains, including all of the B vitamins, to support your body’s healthy energy metabolism. And it contains nutrients found in dairy products, such as calcium, potassium, vitamin A and vitamin D.
Support Healthy Fat and Protein Consumption with Life Force
Low carb lifestyles mean higher consumption of proteins and fats. Unfortunately, there are artery, heart, colon and many other health concerns associated with meals that are high in fat and protein and low in fiber and produce. However, the nutrients in LIFE FORCE can help you better process these foods when eating this way. LIFE FORCE contains high levels of protective fat-soluble antioxidants such as alpha lipoic acid, ascorbyl palmitate (vitamin C ester) and vitamin E to protect your body from the free radicals generated by consuming more fats. It also contains many nutrients for liver health, such as silymarin, CoQ10, NAcetyl Cysteine and turmeric to help support the fat metabolism your liver is responsible for. LIFE FORCE also contains a high level of the B vitamin biotin, which aids in fat, protein and energy metabolism.
Complete Energizing Nutrition
LIFE FORCE is the only multiple to target organ systems with specific nutrients and bio-botanicals, antioxidants and Neuroceuticals® for total body harmony and energy activation, system by system. Only this dedication to going deep to the cellular root of system imbalances can produce a multiple so effective that it is acknowledged in a prestigious scientific review, the Comparative Guide to Nutritional Supplements. A nutritional program with LIFE FORCE at its center can be an easy first step in joining the Wellness Revolution. The goal of this revolution is a long, healthy and fulfilling life. Allow yourself to feel your best, to achieve mental and physical harmony, to radiate energy and vitality. Feel your LIFE FORCE!
R-Lipoic Acid - Fulfilling the Potential of Lipoic Acid
June 04, 2005 02:23 PM
Lipoic acid may be the body’s most versatile nutrient. Its critical importance for health is scientifically documented. Not only is it a powerful antioxidant, it supports healthy sugar metabolism and liver function, and is integral to energy generation, which affects all biological functions. But few know that the commonly available form, alpha lipoic acid (ALA), is not the same compound that occurs naturally in our bodies. ALA is a 50/50 combination of natural form R-Lipoic and synthetic s-lipoic acid—and the synthetic form may actually block the activity of R-Lipoic acid, resulting in a weaker product. Because it is the natural form, R-Lipoic acid is better absorbed and safely metabolized. And it is up to 10 times more effective at producing cellular energy, according to in vitro research, and may be a more potent antioxidant. Source Naturals, the science company, is proud to be one of the first to offer this breakthrough nutrient: R-Lipoic ACID
R-Lipoic Acid: Key to Cellular Energy Generation
Plants capture solar energy in their carbohydrates. In a reverse process called oxidation, animals extract that energy. R-Lipoic ACID is a vital link in the metabolic pathway that gives us the power to move and the energy of intelligence. R-Lipoic ACID is synthesized in the mitochondria, the tiny power plants inside every cell that produce energy in the form of ATP. It is safely metabolized and up to 10 times more effective than other forms of lipoic acid in mitochondrial ATP production, according to an in vitro study.
Supports Glucose Metabolism
Human and animal studies show that R-Lipoic ACID can increase glucose uptake by muscle and nerve cells. By enhancing sugar metabolism, R-Lipoic ACID may protect cells from glycation. In this detrimental process, excess glucose reacts with proteins to create tough crosslinked bonds that damage vital proteins, including the myelin sheath of neurons and the lens of the eye. Scientists believe glycation is a major source of tissue degradation and cellular aging. Collagen, another important protein, is also subject to crosslinking, which inhibits the flexibility of blood vessel walls—one of the most important indicators of cardiovascular health.
Increases Antioxidant Protection
R-Lipoic ACID also neutralizes the harmful byproducts of glucose metabolism, free radicals. The body synthesizes barely enough R-Lipoic ACID for its metabolic needs, and this decreases with age. As mitochondrial energy production becomes less efficient, more free radicals are generated. R-Lipoic ACID protects cells, particularly in the mitochondria, where most oxygen damage occurs. R-Lipoic ACID is a leading component of the body’s antioxidant network. Unlike other antioxidants, it is water and fat-soluble, so it neutralizes a greater number and broader range of free radicals, providing more protection. In animal studies, R-Lipoic ACID slowed the aging process, which may be the result of cumulative oxidative damage. Lipoic acid, known as the “universal antioxidant,” is a strong antioxidant in its own right, but it also directly recycles vitamin C and indirectly recycles vitamin E for continued use. And R-Lipoic ACID is more efficient than other forms of lipoic acid at increasing levels of the key antioxidants, CoQ10 and glutathione. Commercial alpha-lipoic acid is 50% synthetic s-lipoic acid, which can interfere with natural form R-Lipoic ACID when both forms compete for binding sites. Tests showed 40% better absorption by R-Lipoic ACID, as measured by plasma concentration levels.
Integral to Your Wellness Program
Because it is central to such critical functions as energy generation, antioxidant protection, anti-glycation activity, and liver support, R-Lipoic ACID belongs at the center of your wellness program. Source Naturals is happy to join forces with your natural foods retailer in bringing you this advanced nutrient.