Search Term: " Serrapepidase "
Serrapeptidase: Natural NSAID
March 27, 2012 03:26 PM
Serrapeptase, also known as Serratia peptidase is a proteolytic (protein-splitting) bioactive enzyme found in the intestines of the silk worm. This silk-worm enzyme is widely used in Europe and Japan in clinical therapy for relieving pain and inflammation. When the silk worm leaves the cocoon, it regurgitates the serrapeptase in to create a hole in the cocoon for its escape. It was soon discovered that serrapeptase enzyme has a unique property to dissolve dead material consisting protein without even harming the living tissue. This property of dissolving dead tissue can be used in treating many health conditions.
How Serrapeptase work?
Protein is the main component of most of the fibrous materials in the body. Once these fibrous materials out-live their purpose or are over-grown, they start causing serious disease conditions involving fibrosis. Fibrosis is an abnormal thickening and scarring of connective tissue caused by infection, injury, surgery or lack of oxygen. Serrapeptase works as an anti-fibrotic and helps in relieving the conditions in connective tissue scarring and thickening has occurred.
Health Benefits of Serrapeptase:
This proteolytic enzyme is considered an alternative to NSAIDS (Non Steroidal Anti-Inflammatory Drugs) that are used to treat osteoarthritis, rheumatoid arthritis and other inflammatory conditions. Serrapeptase has been used to treat fibromyalgia, colitis, Inflammatory Bowel Diseases, varicose veins, ovarian cysts, ear and throat infections, enlarged prostate and postoperative inflammation. Studies have shown its effective results in prevention and removal of arterial plaque.
Serrapeptase in relieving Pain:
Pain and Inflammation Reduction:
Serrapeptase is a great anti-inflammatory and analgesic agent. It reduces the inflammation and gives relief from the pain. It works by blocking the release of pain inducing amines from the inflamed tissues. Due to its pain relieving and anti-inflammatory properties, serrapeptase is used in treatment as an alternative to NSAIDS. This enzyme gives relief from mild to moderate pain like headache and backaches. Hence it is used all the inflammatory conditions such as colitis, sinusitis, arthritis and many more.
Serrapeptidase has an anti-fibrotic and fibrinolytic action that prevents and treats the accumulation of plaque in the arteries. Plaque is the accumulated deposits of cholesterol, fatty substances, cellular waste products, fibrin and calcium. Excessive plaque formation impairs the normal blood flow and cause partial or complete blockage, which also results in arteriosclerosis. Serrapeptidase helps to prevent build-up of plaque in the body. Due to its fibrinolytic action, it also helps in dissolving of proteins and breaking down atherosclerotic plaques. The dissolved deposits are eliminated from the body.
Hence, serrapeptidase prevents coronary artery diseases and improves cardiovascular health.
Due to its anti-inflammatory and mucus dissolving properties, Serrapeptidase is very beneficial for chronic sinusitis sufferers. Serrapeptidase helps in thinning and expelling the thickened mucus secretion present in nasal cavities of sinusitis sufferer.
Serrapeptidase helps in reducing the recovery time in any injuries, wounds or surgery. It promotes healing in post-operative wounds by reducing the inflammation and pain.
Serrapeptidase is available in the form of supplements. If you are taking NSAIDS for any healthy condition, substitute it with serrapeptidase supplement
How Does Serrapeptidase Support A Healthy Immune System, Regulate Inflammation, And More?
September 01, 2011 02:25 PM
What Does Serrapeptidase Do In The Body?
Serrapeptidase is an enzyme which is protein - digesting by nature. It is considered to be one of the types of proteolytic enzymes which consist of the chemical substance protease. This chemical is derived from a non - genetically engineered fungus of the family of Aspergillus. Serrapeptidase is a dietary supplement which may be isolated from Serrapeptidase oryzae and Serrapeptidase melleus. Studies have claimed that this dietary supplement is effective as an anti - inflammatory, respiratory aid, cardiovascular or immune support. Other names of Serrapeptidase include serration - peptidase and serrapeptase.
During the early 1990’s, Serrapeptidase was isolated from the microorganism Serratia marcescens which is a known human pathogen found in the digestive tract of the Japanese silkworm. Many studies have been conducted to uncover the medicinal purposes of this bacterial enzyme. In fact, it has been widely used clinically in specific areas of Asia and Europe primarily as an inflammation relief agent.
These are some of the uses of the enzyme Serrapeptidase:
1. ANTI – THROMBIC AND FIBRINOLYTIC. Serrapeptidase can significantly prevent the build – up of blood clots. These clots must not be accumulated to prevent thromboembolism which can cause life threatening health conditions such as heart attack and stroke. Aside from its ability to prevent clot formation, Serrapeptidase also has a good fibrinolytic ability. It can lyse or dissolve already – formed blood clots.
2. PH REGULATOR. This proteolytic enzyme is considered to be an alkaline metalloprotease enzyme. It can selectively act on specific biological systems and prevent the activation of immunoglobulin G and immunoglobulin A. These body chemicals are immune system factors which helps the body prevent from infections and illnesses.
3. GOOD PROTEIN DIGESTER. Clinical studies have revealed that Serrapeptidase has a very good ability to digest protein molecules and its substrates. This is the reason behind why Serrapeptidase can effectively dissolve protein – based tissues such as fibrins, blood clots, cysts and certain inflammations. The advantage of this enzyme is that it can dissolve unnecessary tissues without harming the normal living tissues.
4. PROFOUND ANTI – INFLAMMATIORY AGENT. Serrapeptidase can effectively prevent and reduce inflammation, thus reducing swelling and pain sensation. The mechanism of action is said to be that Serrapeptidase blocks the synthesis of pain – inducing amines. Another mechanism is that it can effectively inactivate pro – inflammatory chemicals known as cytokines. In fact, this chemical is one of the components of analgesic drugs in Europe. The positive effect of this enzyme is that it does not have any digestive side effects.
5. RESPIRATORY AID. This enzyme is also helpful in improving the health of the respiratory system. It effectively alters the elasticity and viscosity of the dense mucus in people with respiratory problem such as sinusitis, bronchitis, asthma, and pulmonary diseases. People who are taking this enzyme supplement have shown improved liquefaction and expectoration of the mucus, thus Serrapeptidase is considered to be an effective mucolytic agent widely used all over the world.
Serrapeptidase is generally safe. Clinical studies have revealed that the sources of this enzyme are non – pathogenic except of one strain known as Serratia marcesens. This strain is pathogenic to human body. It may cause hypersensitivity or any untoward signs and symptoms. Therefore, it is best to consult a doctor before starting such supplementation.
New Frontiers in Enzyme Supplementation
February 16, 2006 04:17 PM
New Frontiers in Enzyme Supplementation
By Nick Rana, CN, NOW Quality Assurance
Serrazimes® is a proteolytic (protein digesting) enzyme system containing protease that is derived from edible non-genetically engineered fungi (Aspergillus oryzae and Aspergillus melleus), that is designed as an alternative for Serrapeptidase (also known as serratio-peptidase and serrapeptase) in dietary supplements used for cardiovascular, anti-inflammatory, respiratory, or immune support.
Serrapeptidase was initially isolated from Serratia marcescens, a potentially pathogenic bacteria found in the gut of the Japanese silkworm. Recognized as a pharmacological agent, Serrapeptidase has wide clinical use in Asia and Europe for the management of assorted inflammatory processes (Rothschild, 1991). In recent years, recognition of the efficacy of the Japanese product has lead to growing interest in the US dietary supplement market.
The product’s efficacy and availability over the internet has fueled its popularity in the US dietary supplement industry, where it is used for anti-inflammatory support, cardiovascular support, respiratory support, and as an adjunct to antibiotic therapy. Recognizing the potential for a "Serrapeptidase-type” enzyme in the U.S. dietary supplement market, the National Enzyme Company developed a protease system that has the same in vitro (lab test) activity as Serrapeptidase, but that is from organisms that have a long history of safe use in dietary supplements. Serrazimes® is the product resulting from this search.
Since the 1960’s, plant and microbial protease enzymes have been studied for their role in the management of inflammation and inflammatory processes. In both animal and human trials, proteolytic enzymes, from a variety of sources, have repeatedly been shown to significantly reduce inflammation resulting from sickness or injury (Ryan, 1967)(Smyth et al, 1967)(Shaw, 1969)(Kumakura et al, 1988)(Lomax, 1999). The earlier research on the anti-inflammatory actions of proteases pointed entirely to their antithrombic and fibrinolytic aspects to explain this phenomenon. However, studies by Parmely (Infect and Immun Sept 1990) and others indicate that, in addition to degrading fibrin, microbial proteases may actually inactivate pro-inflammatory cytokines and to interrupt inflammatory responses.
Persons taking blood thinning or antibiotic medications and those with serious health disorders should consult their medical practitioner prior to taking Serrazimes®. As is the case with most supplements, please consult your doctor about the use of Serrazimes® during pregnancy and lactation.
The Product Development Team at NOW Foods is constantly researching new products like Serrazimes® to provide our customers with the tools that empower them to live healthier lives. Look also for our new unique digestive enzyme formulations from plant sources - backed by laboratory studies - to be introduced in March of 2006.
Serrapeptidase is a selective alkaline metalloprotease enzyme, meaning that it works to activate specific biological systems of mammals and directly degrades or inhibits IgG and IgA immune factors as well as the regulatory proteins á-2-macroglobulin, á-2-antiplasmin, and antithrombin III (Molla et al, 1989)(Maeda and Molla, 1989).
While originally isolated from Serratia marcescens, a bacteria found in the gut of the Japanese silk worm, Serrapeptidase activity is also found in fermentation extracts of Serratia E-15, Aspergillus oryzae, and Aspergillus melleus. (Salamone and Wodzinski, 1997).
The Serrapeptidase activity of this high potency proteolytic (protein digesting) enzyme is determined using a spectrophotometric assay testing procedure that measures the enzyme’s ability to hydrolyze (digest) a standard casein protein substrate. Laboratory analyses have established that Serrazimes® has a 1:1 enzymatic equivalent of Serrapeptidase activity guaranteed to provide 600,000 specialized proteolytic Units per gram, or 20,000 units per capsule.