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Link between dietary restriction, longevity examined Darrell Miller 2/9/17
Can L-Carnosine Be Used As An Anti-Aging Vitamins? Darrell Miller 4/18/12
Pinolenic Acid - Appetite Control Darrell Miller 4/25/08
Extended existence? Darrell Miller 5/28/07
7-Keto - The Key to Healthy Aging Darrell Miller 6/21/05
Energize Your Life! Darrell Miller 6/14/05




Link between dietary restriction, longevity examined
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Date: February 09, 2017 12:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Link between dietary restriction, longevity examined





The link between dietary restriction and longevity has been examined. Research has been done and shows that cutting back on calories can actually expand the life span of roundworms. This is important because it shows that we can enhance our health and not have to put huge dietary restrictions on ourselves.

Key Takeaways:

  • Scientists at the MDI Biological Laboratory have published research which improves the understanding of the mechanisms by which the lifespan of roundworms can be lengthened by cutting back on calories.
  • In a paper recently published in the journal “Aging Cell,” MDI Biological Laboratory scientist Aric Rogers shed light on an important genetic pathway underlying this process, raising the possibility that therapies can be developed that prolong the healthy years.
  • The identification of a mechanism underlying the protective effect of dietary restriction could lead to therapies for age-related diseases, including Alzheimer’s and Parkinson’s, that are associated with diminished cellular quality control.

"The life-prolonging effects of dietary restriction, or calorie restriction, occur in just about every animal tested."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//www.mdislander.com/maine-news/link-dietary-restriction-longevity-examined&ct=ga&cd=CAIyGjFlMTFjYzBlYzAwOTU4NjY6Y29tOmVuOlVT&usg=AFQjCNHv80aLt3s3LZ1GHocgqfIfw3hrEw

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Can L-Carnosine Be Used As An Anti-Aging Vitamins?
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Date: April 18, 2012 07:31 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can L-Carnosine Be Used As An Anti-Aging Vitamins?

Carnosine And Your Health

Carnosine has gained widespread popularity as an anti-aging compound despite some skeptical voices in the scientific community. Many studies lend credence to its value for treating the signs of aging and its antioxidant properties are well researched. Carnosine is also widely used as a supplement to prevent complications from diabetes such as nerve and kidney damage. This article will discuss the details of what it is, what it seems to do in the body and how it may be able to help people restore a more youthful state of health.

Discovered in Russia more than a century ago, Carnosine is an amino acid and is found primarily in muscle, skeletal and nervous tissue (including the brain). As such the primary dietary sources are animal products such as fish, poultry and red meat. It is common for vegetarians to become deficient in it, making them ideal users of carnosine supplements.

Glycation

There is a gradual decline in carnosine levels as we age, which lends credence to the claims of its anti-aging properties. The most clearly established property of carnosine is its ability to act as an anti-glycation agent. Glycation is a process the body goes through to release energy from sugar but which ends up producing harmful substances. Carnosine can neutralize some of these already formed substances and also prevent the process from forming new ones. Some researchers believe glycation may be the key behind the benefits of caloric restriction, making carnosine the long awaited magic pill that can mimic its effect as a longevity treatment without the deprivation of restricting food intake.

Antioxidant Properties

In addition to carnosine's anti-glycation effect, it also has antioxidant properties. The oxidation process which the body goes through naturally produces the well known "free radicals" which slowly damage the cells and are thought to play an important role in the aging process. Carnosine can neutralize this protecting the cells. This also has a beneficial effect at keeping the telomeres from shortening, which is thought to be the main cause of the aging process. Telomeres are the buffers at the ends of DNA code that protect the code from being corrupted, so when the telomeres become shorter there is less protection and a greater chance of things going wrong. This makes carnosine's protective benefits of great importance in the fight against aging.

Carnosine Protects The Cells From Damage Like Radiation

Studies show that carnosine can protect the cells from radiation damage, which is particularly useful for cancer patients who have to undergo radiological treatment. It also promotes the healing of wounds and protects cell membranes. Some studies demonstrate that it can literaly repair old cells and make them younger. As it binds easily to toxic metals, turning them into powerful antioxidants, it is very effective at protecting the body from their harmful impact.

Some of the most promising uses of carnosine are for the treatment and prevention of Alzheimer, the signs of aging in the skin, cataract, nerve and kidney damage and heart disease. The recommendation for use as a supplement is 500 miligrams, though the body can deal safely with much larger doses. Give Carnosine a try today and experience the difference yourself.

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Pinolenic Acid - Appetite Control
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Date: April 25, 2008 02:50 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Pinolenic Acid - Appetite Control

Mention "pine nuts" and peoples’ mouths are apt to start watering for a taste of garlicky pesto or fragrant pilaf. Ironically, the same ingredient that is so irresistible in gourmet cooking may help curb our out-of-control appetites. But only a particular variety of pine nut—Pinus koraiensis from Korea—will do.

Source Naturals PineSlim is a Korean pine nut oil (PinnoThin™). A small-scale study suggests that PineSlim may reduce feelings of hunger by increasing concentrations of appetite-suppressing hormones. The study also suggests that a feeling of fullness is experienced 30-60 minutes after taking PineSlim. For best results, PineSlim should be taken while following the Maximum Metabolism Weight Loss Plan™ enclosed in every bottle.

Enjoying good food is part of a healthy lifestyle, but too often we don’t know when to stop. PineSlim can help by addressing one of the most basic of the dozen deep metabolic systems identified by Source Naturals as critical to your optimal health: Hormones/Metabolism.

Less Calories for Improved Health

According to a National Health and Nutrition Examination Survey, an estimated 66% of U.S. adults are overweight. A normal body fat level is one of the factors associated with many markers of good health, including insulin efficiency, healthy inflammation response, good circulation, and normal cell regeneration. One of the best ways to achieve healthy weight is by curbing the amount of calories we take in—but that’s not always easy to do. Now an ancient Asian food source may help.

Korean Pine Nuts—Traditional Asian Food

The Korean pine nut (Pinus koraiensis) has been used as a food source for centuries and is often served as a snack at social events in China. Korean pine nuts grow on evergreen trees that produce seeds (commonly referred to as nuts) that are rich in oil, particularly oleic, linoleic, and pinolenic acids.

Pinolenic acid is a fatty acid, which may influence healthy blood pressure. According to recent research, pinolenic acid also may increase concentrations of the satiety hormones glucogon-like peptide-1 (GLP- 1) and cholecystokinin (CCK).

Appetite-Suppressing Hormones

Both GLP-1 and CCK are hormones that have been found to increase satiety and suppress appetite in normal-weight humans. They are believed to work by delaying gastric emptying. Retaining food in the stomach for a longer period of time may prolong a feeling of fullness.

In a randomized, double-blind trial, 18 overweight women received 3.00 grams of Korean pine nut oil (PinnoThin™)—the same amount as one daily dose of Pine Slim—or an olive oil placebo before a carbohydrate meal. Hormone measures of CCK and GLP-1 were taken from blood samples, and subjective measures of appetite were recorded. The study demonstrated a significant increase in appetite-suppressing CCK and GLP-1 hormones at 30-60 minutes after supplementation.

Your Source for Advanced Nutrition

The plant world offers an abundance of health promoting compounds. Today exciting discoveries are emerging from research into the health benefits of botanicals. The development of PineSlim reflects Source Naturals’ commitment to manufacturing supplements on the cutting edge of nutritional science. We are glad to partner with your local health food store in bringing you nutritional resources that help you take charge of your health.

References:

Causey JL (3/28/06) Korean Pine Nut Fatty Acids Induce Satiety-producing Hormone Release in Overweight Human Volunteers, American Chemical Society Abstract, “Health Benefits of Lipids” Symposium. ABSTRACT 0117: TECH-3.

Fontana L. (2006) Excessive Adiposity, Calorie Restriction, and Aging. JAMA. 295(13): 1577-1578. Masoro EJ. (2005) Overview of caloric restriction and ageing. Mech Ageing Dev. 126: 913-922. Sugano M, Ikeda I, Wakamatse K, Oka T. (1994)

Influence of Korean pine (Pinus koraiensis)-seed oil containing cis-5,cis-9,cis-12-octadecatrienoic acid on polyunsaturated fatty acid metabolism, eicosanoid production and blood pressure of rats. British Journal of Nutrition. 72:775-783.

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Extended existence?
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Date: May 28, 2007 11:33 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Extended existence?

Humankind has long searched for a special elixir that would confer immortality…or, failing that, at least prolong youthful vitality for a decent number of years. Resveratrol is no magic potion, but it has improved survival rates among mice at the ripe old age (for a mouse) of 114 weeks even overweight mice fed high-calorie chow (Nature online 11/1/06). What’s more the Resveratrol bolstered rodents stayed fit and trim well into their senior years; as Dr. Rafael de Cabo of the National Institute on Aging told the news service heartwire, such a finding “suggests that this compound may not just extend life but may also enable individuals to lead healthy and functional lives for longer.”

While tests continue on how Resveratrol could produce these results, it is believed that this substance may actually mimic the effects of calories restriction, which has been shown to increase longevity. Resveratrol apparently activates a gene known as SIRT1 activation is also associated with greater exercise capacity and fat burning.) in addition, Resveratrol both acts as an antioxidant itself by mopping up dangerous molecules called free radicals and helps enhance the antioxidant effects of vitamin C and E.

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7-Keto - The Key to Healthy Aging
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Date: June 21, 2005 05:05 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: 7-Keto - The Key to Healthy Aging

7-Keto " The Key to Healthy Aging

The global population is aging at an alarming rate and causing an explosion in health care costs, insurance premiums, cosmetic surgery and more. In the U.S. alone, more than one million baby boomers are expected to live to 100 years of age or older. This increased life expectancy presents a whole new set of health concerns that the medical community has not had time to address, since there is a greater need to care for age-related health problems in this ever-growing elderly population.1

Aging and the Decline in Vital Nutrients

We all grow old at the same rate but people age at different rates. Aging is a process of gradual changes that occur to varying degrees in each of us. Interestingly, the aging process is composed of different components and interactions, some of which can be impacted. One such component is the declining level of essential biological compounds, which causes our bodily functions to slow and become dysfunctional. Our organs don?t work efficiently, our immune system becomes lazy, we lack energy, our metabolism drops and we gain weight easily.1 7-oxo DHEA (7-Keto™) is a naturally occurring compound that declines with age.2 Replacing this key metabolite helps promote a healthy immune system and maintains resting metabolic rate at levels that accelerate weight loss during standard weight reduction programs.

Aging and a Healthy Immune System

Numerous changes occur in the immune system with advancing age, probably contributing to decreased immune responsiveness. Although all segments of the immune system are affected, investigators have most consistently identified declines in cellular or T-cell mediated immune function in the elderly. The decline in T-cell immune function is generally associated with an increased susceptibility to foreign organisms. For example, individuals with age-related declines in cellular immunity have an impaired response to vaccinations, making them more susceptible to health imbalances even though they have had their shots. In a clinical study presented at the Federation of American Societies for Experimental Biology meeting in April 2004, the effect of 7-Keto on elderly immune function was evaluated. Healthy elderly adults were given 7-Keto orally twice daily over a period of one month. The study revealed that 7-Keto augmented several key T-cell mediated immune function parameters compared to placebo administration.4

Age-Related Weight Gain

Age-related weight gain and obesity are approaching epidemic proportions in our country.5 Weight gain is a disorder of energy balance involving energy intake and/or expenditure. Low energy expenditure, a drop in resting metabolic rate (RMR), is a challenge during most weight loss attempts due to age, calorie restriction, lack of physical activity or a combination of factors. RMR represents 60% of total daily energy expenditure. Maintaining a higher RMR as we age and during weight reduction programs helps us achieve and maintain a normal weight. Furthermore, compounds with the thermogenic potential to achieve even minimal increases in daily energy expenditure of 2-3% may have clinical relevance in preventing the decline in RMR with calorie restricted diets or weight loss, and in decreasing the risk of regaining weight. 7-Keto, a non-stimulant thermogenic compound, has been shown to significantly increase energy expenditure in humans.6 A recently completed clinical study, also presented at the Federation of American Societies for Experimental Biology 2004 meeting, revealed that administration of 7-Keto to overweight adults in conjunction with a calorie restricted diet effectively reversed the decline in RMR normally associated with dieting. Obese participants following a calorie-restricted diet demonstrated a 5.4% increase in daily RMR with 7-Keto.7 The magnitude of the increase in RMR by 7-Keto is clinically relevant, and represents a promising agent for enhancing thermogenesis and weight loss in obese individuals on calorie-restricted diets. Additionally, 7-Keto has been shown in two confirmatory published clinical studies to result in three times more weight loss compared to diet and exercise alone. It has a favorable side effect profile and is easy and convenient to take.8,9 Our life expectancies will likely be longer than those of our parents, and our quality of life during those years will depend on how well we take care of our bodies now. Undoubtedly, the science of aging will give rise to new and exciting technologies to help us age more gracefully and healthfully. Maintenance of healthy immune function is keenly needed for improved quality of life in the elderly. Dietary manipulation and supplementation has been identified as a method of immune system renewal, and supplements such as 7-Keto may play an important future role as immune system modulators. Moreover, the addition of 7-Keto to any weight loss program will offer vital support of energy expenditure and help with the attainment of a manageable and healthy weight into our older years.

References

1. 1995 White House Conference on Aging, ?Executive Summary: The Road to an Aging Policy for the 21st Century," February 1996: 17-18. 2. Marenich LP. Secretion of Testosterone, Epitestosterone, Androstenedione, and 7-Keto-Dehydroepiandrosterone in Healthy Men of Different Ages. Prob Endokrinol. 1979; 25(4): 28-31. 3. Ginaldi L, De Martinis M, D?Ostilio A, Marini L, Loreto MF, Quaglino D. Immunological Changes in the Elderly. Aging 1999; 11(5): 281-286. 4. Zenk JL, Kuskowski MA. The Use of 3-acetyl-7-oxo-dehydroepiandrosterone for Augmenting Immune Response in the Elderly, Abstract Presented at the meeting of the FASEB, April 17, 2004, Manuscript submitted for publication. 5. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and Trends in Obesity Among US Adults. 1999-2000. JAMA 2002;288:1723-1727. 6. Astrup A. Thermogenic Drugs as a Strategy for Treatment of Obesity. Endocrine 2000;13(2):207-212. 7. Zenk JL, Leikam SA, Kassen LJ, Kuskowski MA. A Prospective, Randomized, Double Blind Study to Evaluate the Effect of HUM5007 and 7-oxo DHEA on Resting Metabolic Rate in Overweight Adult Men and Women on a Calorie Restricted Diet, Abstract Presented at the meeting of the FASEB, April 17, 2004, Manuscript submitted for publication. 8. Kalman DS, Colker CM, Swain MA, Torina GC, Shi Q. A Randomized, Double-Blind, Placebo Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Healthy Overweight Adults. Current Therapeutic Research 2000;61: 435-442. 9. Zenk JL, Helmer TR, Kassen LJ, Kuslowski MA. The Effect of 7-Keto Naturalean on Weight Loss: A Randomized, Double-Blind, Placebo-Controlled Trial. Current Therapeutic Research 2002; 63:263-272.

John L. Zenk, M.D., is Chief Medical and Scientific Officer for Humanetics Corporation and President and Medical Director of Minnesota Applied Research Center, both located in Eden Prairie, MN. He has spoken nationally and internationally on the subjects of integrating conventional and complementary medicine, anti-aging technologies, evaluating the effectiveness of alternative medicine, and dietary supplement research and development. He is author of the book Living Longer in the Boomer Age, and co-author of the book Age Wise and is a frequent contributor to national media. He has served as Principal Investigator for 15 controlled clinical studies, three of which were recently published in national peer-reviewed journals, and has presented abstracts at the 11th World Congress for Food Science and Technology and the Federation of American Societies for Experimental Biology.



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Energize Your Life!
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Date: June 14, 2005 05:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Energize Your Life!

Energize Your Life!

by Laura Weiss Energy Times, December 1, 2003

If every fatigued day leaves you wondering where your energy went, you need a personal energy makeover.

"Energy, some special kind of energy, just leaks out and I am left lacking the confidence even to cross the street," Diane Arbus, the photographer, once complained. And while Ms. Arbus tried to overcome her energetic and spiritual ups and downs with her art, you can use lifestyle changes as well as self-expression to revive your vigor.

To Sleep, Perchance to Energize

When you're looking for a boost in personal energy, you've got to get enough sleep, insists Jacob Tietelbaum, MD, author of From Fatigued to Fantastic! (Avery). Dr. Teitelbaum emphasizes that unless you "give your body eight to nine hours of sleep per night," your personal energy will never be adequate.

Studies show that getting less than six hours sleep a night hurts your mental performance and drains your energy (Sleep 3/15/03). As your sleep debt builds up, your energy drops down.

"[Our studies show] the importance of sleep as a necessity for health and well-being. Even relatively moderate sleep restriction, if it is sustained night after night, can seriously impair our neurobiological functioning," says Hans P.A. Van Dongen, PhD, Assistant Professor of Sleep and Chronobiology at Penn State.

A recent poll by the National Sleep Foundation found that Americans, on average, are getting less than seven hours of shuteye a night. That sleep deficit drains energy.

Watered Down Energy

Added to that sleep requirement, Dr. Teitelbaum stressed in an interview with Energy Times, a lack of water can deplete your personal energy.

"The number one problem is often dehydration," he says. "Make sure you stay hydrated. Although I think it's a bad idea to [obsessively] count glasses of water, you should carry a bottle of water with you, check your lips and if they feel dry drink more water." Overall, your body is about 60% water and 70% of your muscles consist of water. If you let your water levels dip too low, your muscles suffer and your energy levels dip as well. Research shows that as your body dries out, your mental processes can slow down. And the hotter the temperature, the more fluid you may lose (AIHAJ 2002; 63(2):190-8).

B Vitamins for Energy

Also important for keeping your energy up "is getting enough of the B vitamins and magnesium." And even though Dr. Teitelbaum advocates the necessity of a well-rounded multiple vitamin and mineral supplement plus an adequate diet and amino acids to get all the nutrients you need, he recommends "taking a high-level B complex. The RDAs (the government's Recommended Daily Amounts) are inadequate."

In the body, B vitamins are used for the production of energy on a cellular level. For instance, vitamin B1 (thiamine) is crucial for burning carbohydrates effectively. And vitamin B6 (pyridoxine) is necessary for the body's ability to properly use B1. At the same time, vitamin B12 (cobalamin) is required for proper nerve function. The need for B12 may necessitate a supplement: Up to 30% of everyone over the age of 50 may have trouble absorbing B12 from their food (Crit Rev Clin Lab Sci 1996; 33:247). Plus, since vegetables contain very little absorbable B12, vegetarians of all ages may also require B12 supplements.

Dr. Teitelbaum also believes that taking malic acid, a nutrient derived from apples, can help. Along with the B vitamins, malic acid is used by the body in the production of energy. When taken with magnesium, malic acid has been shown to ease the pain of fibromyalgia (J Rheum 1995; 22(5):953-7), a condition characterized by fatigue and lack of energy accompanied by painful muscles and joints.

Ginseng Boost

Asian ginseng (Panax ginseng) represents a potential tool for controlling blood sugar and improving stamina.

According to Dr. Teitelbaum, "...Asian ginseng enhances energy, raises blood pressure and improves adrenal function...Asian ginseng has such a wide mix of health benefits that its name, Panax, comes from the Greek roots of pan (meaning 'all') and akos (meaning 'cure')-that is, 'cure all.'"

Research on people with diabetes shows that this herb may help control blood sugar levels. People who suffer what is called type 2 diabetes often eat small meals to keep their blood sugar from varying too much. (Rising and falling blood sugar can drain you of energy as well as make diabetic problems worse.)

An investigation of how another form of ginseng, American ginseng (Panax quinquefolius), affects blood sugar after eating found that it tempered changes by up to 20% (Arch of Internal Med 4/00). These scientists found that folks with diabetes did best when they took the herb within two hours of a meal.

Ready to re-energize? Time to stop skimping on sleep and rushing through inadequate meals. For all of us, slowing down and giving our bodies a chance to regenerate its zip can make the big energy difference.



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