- UPC: 857549002206
- # LG0106
Pet Wafers KollaGen II-xs Plus MSM and CMO – Advanced Avian Cartilage Joint Support for Dogs & Cats
Longevity by Nature’s Pet Wafers KollaGen II-xs™ Plus MSM & CMO delivers a clinically validated, multi-pathway chondroprotective formula designed to restore synovial fluid viscosity, protect articular cartilage matrix integrity, and alleviate degenerative joint stiffness in senior and performance pets.
Targeted Articular Support: The Biology of Canine and Feline Cartilage Degradation
In companion animals, degenerative joint conditions such as osteoarthritis (OA) and degenerative joint disease (DJD) stem from an imbalance between the catabolism and anabolism of the extracellular cartilage matrix (ECM). As chondrocytes undergo oxidative stress and mechanical wear, endopeptidases—specifically matrix metalloproteinases (MMPs) and aggrecanases—cleave native type II collagen fibrils and aggrecan polymers. This enzymatic breakdown thins the articular cushion, dries out the synovial capsule, and provokes chronic low-grade synovitis.
Standard pet supplements often rely on standalone synthetic glucosamine HCl or unhydrolyzed bovine collagen (Types I and III), which do not supply the specific structural proteins required by hyaline cartilage. Pet Wafers KollaGen II-xs™ Plus MSM & CMO counters degenerative joint cascades through a synergistic four-part matrix: bioactive hydrolyzed avian sternum type II collagen peptides (standardized to 20 kDa molecular weight), organic sulfur donor methylsulfonylmethane (MSM), cell-membrane lubricant cetyl myristoleate (CMO), and trace manganese sulfate.
Guaranteed Analysis & Complete Ingredient Profile
Each chewable chicken-flavored wafer is manufactured under strict cGMP standards, formulated without harsh chemical extraction solvents, and standardized for maximum bioavailability across small, medium, and giant breeds.
| Active Ingredient |
Potency per 1 Wafer |
Biochemical Role & Active Components |
| KollaGen II-xs™ Hydrolyzed Avian Sternum Type II Collagen |
700 mg |
Naturally sourced from pure young chicken sternum cartilage. Standardized to 65% collagen protein peptides (18 essential amino acids) and 35% naturally occurring mucopolysaccharides (~10% Hyaluronic Acid, ~20% Chondroitin Sulfate A, and ~3% Glucosamine). Hydrolyzed to an optimized Dalton weight of 20,000 Da (20 kDa) for maximum intestinal assimilation.
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| Methylsulfonylmethane (MSM) |
200 mg |
Bioavailable organosulfur compound serving as a primary sulfur donor for disulfide bridging in articular collagen fibers. Suppresses NF-κB inflammatory signaling and reduces intra-articular oxidative markers.
|
| Cetyl Myristoleate (CMO) |
45 mg |
Esterified fatty acid complex (cis-9-cetyl myristoleate) acting as a biological surfactant and lubricant across synovial membranes, modulating 5-lipoxygenase (5-LOX) pathway inflammatory cascades.
|
| Manganese (as Manganese Sulfate) |
5 mg |
Essential mineral cofactor for glycosyltransferase and chondroitin sulfotransferase enzymes, required for the endogenous synthesis of cartilage glycosaminoglycans (GAGs).
|
Inactive Ingredients: Microcrystalline cellulose, magnesium stearate (vegetable source), natural chicken flavor.
Free Of: Wheat, gluten, corn, soy, dairy, synthetic dyes, artificial preservatives, chemical solvents, GMOs, and TSE/BSE agents.
How KollaGen II-xs™ Plus MSM and CMO Restores Pet Mobility
1. Molecular Weight Optimization: The 20 kDa Bioavailability Advantage
Native unhydrolyzed collagen from raw cartilage possesses a dense triple-helix molecular weight of roughly 300,000 Daltons (300 kDa)—far too large for reliable absorption across the canine or feline enterocyte barrier. KollaGen II-xs™ utilizes a patented solvent-free, low-temperature water extraction process that reduces the molecular chain length to approximately 20 kDa. This preserves the delicate glycosaminoglycan bonds (hyaluronic acid, chondroitin, and glucosamine) intact while allowing rapid transmucosal transport into systemic circulation to feed chondrocytes.
2. Synovial Viscoelasticity & Articular Lubrication
Synovial fluid functions as the hydraulic shock absorber inside moving joints. Age and joint stress deplete natural hyaluronan levels, causing bone-on-bone friction. The naturally bound hyaluronic acid and chondroitin sulfate in KollaGen II-xs™, working in tandem with the fatty-acid ester matrix of Cetyl Myristoleate (CMO), replenish the lubricity and thickness of synovial fluid. This biological lubrication cushions high-impact joints including hips, stifles, hocks, and spinal vertebrae.
3. Sulfur-Driven Collagen Synthesis & Downregulation of Synovial Inflammation
Cartilage resilience depends on rigid disulfide bonds between neighboring amino acid strands. Methylsulfonylmethane (MSM) provides a direct sulfur substrate for chondroitin-4-sulfate and chondroitin-6-sulfate synthesis. Simultaneously, MSM downregulates the transcription factor NF-κB, which reduces the production of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, dampening the cycle of post-exercise stiffness and morning immobility.
Clinical Research & Peer-Reviewed Scientific Foundations
The nutritional formulation behind Pet Wafers KollaGen II-xs™ Plus MSM and CMO is supported by clinical trials and veterinary orthopedic literature:
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Avian Sternum Type II Collagen in Canine Osteoarthritis: A randomized veterinary clinical study published in the Journal of Animal Physiology and Animal Nutrition (and corroborated by trials in the Journal of Veterinary Pharmacology and Therapeutics) demonstrated that type II collagen derived from chicken sternum cartilage resulted in a statistically significant reduction in pain during limb manipulation, reduced overall lameness, and increased peak vertical force (PVF) on computerized gait analysis without adverse hepatic or renal side effects.
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KollaGen II-xs™ Specialized Clinical Testing: In a double-blind, 30-day human clinical trial evaluating KollaGen II-xs™ at 1,500 mg daily, subjects exhibited a 33% increase in joint flexibility, significant decreases in range-of-motion pain (p = 0.021), and normalization of salivary inflammatory pH markers within 30 days, confirming the biological activity of its 20 kDa peptide matrix.
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Efficacy of Cetyl Myristoleate (CMO) for Joint Kinematics: Peer-reviewed orthopedic evaluations (including clinical findings by Diehl & May and veterinary comparative studies) report that cis-9-cetyl myristoleate acts as a natural chondroprotective surfactant. CMO supports membrane elasticity, dampens prostaglandin synthesis, and accelerates functional mobility recovery in arthritic animals.
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MSM Synergistic Chondroprotection: Clinical trials compiled in Veterinary Sciences and BMC Veterinary Research show that dietary methylsulfonylmethane supplementation preserves articular cartilage thickness and reduces synovial matrix oxidative stress when paired with natural glycosaminoglycans.
Feeding Directions & Weight-Based Dosing Protocol
For optimal assimilation of hydrolyzed collagen peptides, administer Pet Wafers daily on an empty stomach approximately 20 to 30 minutes before feeding. For finicky eaters, wafers are easily broken or crushed directly into wet or dry pet food.
| Pet Weight Category |
Daily Maintenance Dose |
Initial Loading Dose (First 3-4 Weeks) |
| Small Dogs & Cats (Under 25 lbs) |
½ Wafer Daily |
1 Wafer Daily |
| Medium Dogs (25 to 50 lbs) |
1 Wafer Daily |
2 Wafers Daily (Split AM/PM) |
| Large & Giant Dogs (Over 50 lbs) |
2 Wafers Daily |
3 to 4 Wafers Daily (Split AM/PM) |
