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- UPC: 733739001375
The Health Benefits and Toxicity of SAMe
S-adenosyl-L-methionine, otherwise referred to as SAMe, is used by many to treat depression - some of these self-prescribed and administered. This can happen because SAMe is not regulated by the FDA, although it is prescription medicine in Europe. Others take it simply to improve mood and their feeling of well-being, while for yet others it relieves the symptoms of osteoarthritis. In that respect it offers similar effects to the anti-inflammatory properties of aspirin. It can also be use in cases of cirrhosis of the liver and fibromyalgia, so SAMe is an extensively used medication. Make sure your doctor knows before using it!
Because it is available without prescription in the USA, the question must then arise of toxicity. What are the risks of taking SAMe, if indeed there are any? Perhaps that question could be answered by the fact that in the region of 17 million Italians have been taking SAMe under prescription since 1976 in Europe, so its use has been controlled. Of these, there have been no reports of serious problems through its use.
There have also been no reports of adverse interactions with other drugs or dietary supplements, although 1.6 grams (1600 mg) was the highest dose used so should be regarded as the maximum safe dose. It also makes sense for pregnant and lactating women to seek the advice of their doctor or physician before using it in the USA and SAMe should not be administered to children. Tests on bipolar patients indicate that their switch to extreme elation is evidence that they should refrain from using SAMe until they have sought the advice of their medical advisor.
Serving Size: 1 Tablet
Suggested Use: As a dietary supplement, take 1 tablet 1 - 2 times daily, preferably on an empty stomach. Refrigeration is recommended after opening.
Free of: sugar, starch, yeast, wheat, gluten, corn, soy, milk or preservatives.
Other Ingredients: Cellulose, Croscarmellose Sodium, Methacrylic Acid, Magnesium Stearate (vegetable source), Silica, Trietyyl Citrate, Stearic Acid (vegetable source), Citric Acid and Ascorbic Acid.
Warnings: Individuals with bipolar (manic) depression should not take SAMe unless under professional supervision. CAUTION: Please discard the inedible freshness packet enclosed.
Though discovered in 1952, the past six years have crowned SAMe as one of the most widely used supplements in today’s marketplace. As a natural line of support to the nervous system functions, it increases the synthesis and breakdown of certain neurotransmitters, thus enhancing the sensitivity of nerve receptors. It may also aid in the repair of myelin, the sheath of fatty material that surrounds the nerve cells. SAMe may support joint health through transulfuration, a process that takes a certain amount of sulfur from SAMe to create glucosamine and chondroitin sulfates. This enhances proteoglycan synthesis, the molecule responsible for keeping articular joint cartilage lubricated. Important for the production of glutathione, this powerful free radical scavenger defends the body from toxic agents and is necessary for liver detoxification.*