- UPC: 733739030498
- # N3049
NOW Foods DIM 200 (Diindolylmethane) - 90 Veg Capsules
Targeted Hormone Balance & Detoxification Support for Men and Women*
Maintain healthy estrogen metabolism and cellular health with NOW® DIM 200 (Diindolylmethane). Formulated with an extra-strength 200 mg dose of pure 3,3’-Diindolylmethane, this advanced endocrine support supplement is fortified with Calcium D-Glucarate (100 mg) and Sodium Copper Chlorophyllin (20 mg) to optimize both Phase I and Phase II hepatic detoxification pathways.*
Whether you are seeking relief from monthly cyclical discomfort, looking to clear hormone-driven skin blemishes, or aiming to support an optimal testosterone-to-estrogen balance, NOW® DIM 200 delivers a clinically backed, food-derived botanical solution in convenient vegetarian capsules.*
What is DIM (Diindolylmethane)?
Diindolylmethane (DIM) is an active lipophilic phytochemical and the primary active metabolite of Indole-3-Carbinol (I3C), an organic compound found naturally in cruciferous (Brassica) vegetables such as broccoli, Brussels sprouts, kale, cabbage, and cauliflower.
When you consume cruciferous vegetables, stomach acid catalyzes the breakdown of I3C into DIM. However, you would need to eat roughly two pounds of raw broccoli daily to obtain the active levels provided in a single 200 mg vegetarian capsule of NOW® DIM 200. Supplementing with pure diindolylmethane ensures a direct, reliable, and biologically active dose without gastrointestinal bloating.*
How Does DIM 200 Work in the Body?
DIM does not mimic or replace your body’s natural hormones; instead, it acts as a metabolic modulator by steering hepatic estrogen breakdown into safer, protective pathways.*
How Does DIM 200 Work in the Body?
DIM does not mimic or replace your body’s natural hormones; instead, it acts as a
metabolic modulator by steering hepatic estrogen breakdown into safer,
protective pathways.*
Cruciferous Indoles (I3C) + Gastric Acid ? 3,3'-Diindolylmethane (DIM)
¦
?
Liver Cytochrome P450 Enzymes (CYP1A1 / CYP1A2)
¦
+-------------------------------+
? ?
2-Hydroxyestrone (2-OHE1) 16a-Hydroxyestrone (16a-OHE1)
[Protective Pathway] [Proliferative Pathway]
? ¦
¦ DIM actively increases ¦
+------ this healthy ratio -----+
1. Shifts Estrogen Toward the "Protective" 2-OHE Pathway
In the liver, circulating estrogens (estrone and estradiol) are metabolized via the
cytochrome P450 enzyme system into distinct downstream hydroxylated metabolites:
- 2-Hydroxyestrone (2-OHE1): Commonly known as the "good" estrogen metabolite,
2-OHE displays mild, protective activity and helps safeguard hormone-sensitive tissues
such as the breasts, cervix, and prostate.*
- 16-Alpha-Hydroxyestrone (16a-OHE1) & 4-Hydroxyestrone (4-OHE):
Higher circulating ratios of these reactive metabolites are associated with estrogen dominance,
tissue irritation, and fluid retention.*
DIM enhances the activity of the
CYP1A1 and
CYP1A2 enzymes,
shifting estrogen metabolism toward the protective 2-OHE pathway and optimizing the
2:16-alpha-hydroxyestrone ratio in both women and men.*
2. Complete Detoxification: Why Calcium D-Glucarate Matters
Transforming estrogen into 2-OHE is only the first step (Phase I). To safely eliminate these
metabolites, the liver binds them to glucuronic acid in a Phase II pathway called
glucuronidation.*
However, an enzyme produced by certain gut bacteria called
beta-glucuronidase
can break this bond, freeing deactivated hormones and environmental toxins to be reabsorbed back
into the bloodstream (enterohepatic recirculation).
NOW® DIM 200 includes 100 mg of
Calcium D-Glucarate, a targeted nutrient that directly inhibits beta-glucuronidase,
ensuring spent estrogens and xenoestrogens are permanently eliminated through the bowel.*
, a water-soluble
plant pigment that provides potent antioxidant support, helps neutralize free radicals, and
supports healthy internal cleansing.*
