Nattokinase 100mg - 60 Vcaps

Product Overview: Standardized Fibrinolytic Enzyme Support

Think of your circulatory blood vessels like household water pipes. Over time, microscopic protein mesh can collect along vessel walls and slow fluid flow. NOW® Nattokinase 100 mg functions like an organic precision drain sweeper, breaking down stubborn cellular debris to keep circulation moving freely.

Each vegetarian capsule delivers 2,000 Fibrinolytic Units (FU) of pure enzyme derived from non-GMO fermented soybeans (natto). This formula is completely free of Vitamin K to ensure smooth, unhindered vascular support.

• ✓ Active Form & Potency: 2,000 Fibrinolytic Units (FU) from 100 mg of standardized nattokinase extract per single capsule.
• ✓ Primary Target: Promotes vascular protein breakdown (fibrinolysis), arterial flexibility, and healthy blood viscosity.
• ✓ Supply & Value: 60 vegetarian capsules per bottle, providing a full 60-day daily cardiovascular maintenance supply.
• ✓ Purity & Dietary Status: 100% vegetarian, non-GMO soy-derived, Vitamin K-free, and packaged in a 100% post-consumer recycled bottle.

Buyer's Guide: Understanding Your Cardiovascular Options

Why the Form Matters: Nattokinase vs. Red Yeast Rice

Shoppers often confuse Nattokinase with Red Yeast Rice, but they perform completely different jobs in the body. Red Yeast Rice works in the liver to modulate cholesterol production. Nattokinase works directly inside the bloodstream like a mechanical broom to dissolve excess structural protein fibers. If your primary goal is smooth blood thickness and clear circulation rather than cholesterol management, Nattokinase is your ideal choice.

Cheap formulas found on big-box store shelves often use crude, unstandardized natto powders. Many leave behind naturally occurring Vitamin K, which promotes blood clotting and cancels out the circulatory benefits. Worse, cut-rate store brands frequently skip raw material screenings, leaving products exposed to heavy metals and microbial residues. NOW® removes all Vitamin K, guarantees active 2,000 FU potency, and screens every batch for purity.

Is This Formula Right for You?

• ✓ Proactive Adults: Individuals seeking to support supple blood vessels, healthy blood flow, and normal blood pressure ranges.
• ✓ Frequent Travelers & Desk Workers: People looking to support lower extremity blood flow during extended sitting or flights.
• ✓ Clean Supplement Users: Anyone wanting a Vitamin K-free, non-GMO systemic enzyme free of synthetic additives.

• ✗ Anticoagulant Users: Anyone taking prescription blood thinners (like warfarin, heparin, or daily aspirin) without medical supervision.
• ✗ Pre-Surgery Patients: Individuals scheduled for surgical or dental procedures within the next 14 days.
• ✗ Active Bleeding Conditions: Anyone experiencing stomach ulcers, recent physical trauma, or known coagulation disorders.

Try this formula with complete confidence under VitaNet®, LLC's 31-year reputation and unconditional 100% money-back guarantee, allowing you to evaluate your results risk-free even on opened bottles.

How It Works in the Body

Imagine a spiderweb that traps falling leaves in a slow garden stream. In your cardiovascular system, a web-like structural protein (fibrin) gathers cells together to form blood clots. When circulation slows, excess fibrin makes blood thick and sluggish.

Nattokinase functions as a specialized biological cutting tool (serine protease). Once absorbed into your circulation, it supports blood vessel clarity through two distinct pathways:

• 1. Direct Protein Breakdown: Nattokinase directly snips cross-linked fibers of structural protein (fibrin), breaking them into tiny, harmless fragments [1].
• 2. Activating Internal Defense Enzymes: It boosts your body's native cleanup enzyme (plasmin) by increasing tissue plasminogen activator (tPA) while reducing inhibitor proteins (PAI-1) [1, 3].

By supporting natural protein clearance, nattokinase helps maintain healthy blood thickness and promotes vascular ease [2, 3]. Long-term clinical trials confirm that regular intake supports arterial flexibility and optimal cardiovascular performance [2, 4].

Daily Timing, Synergy & Realistic Timelines

Best Time to Take

Always take nattokinase on an empty stomach with a full 8-ounce glass of water. If taken with a meal, the enzyme acts as a digestive aid, breaking down proteins in your food. Consuming it at least 30 to 60 minutes before eating or 2 hours after a meal ensures it passes intact into your bloodstream.

Daily Schedule

Take your single daily capsule at night right before going to bed. Blood flow naturally slows during sleep, and vascular drag peaks in the early morning hours. Nighttime dosing provides peak systemic enzyme concentration when your circulatory system needs it most.

Smart Pairings & Spacing

Pair nattokinase with Coenzyme Q10 (CoQ10) or Omega-3 fish oil for enhanced cellular energy and vessel wall health. Keep a strict 2-hour window away from activated charcoal, bentonite clay, or heavy fiber supplements that can bind active enzymes.

What to Expect Over Time

• ✓ Days 1–7: The enzyme enters circulation within 2 to 4 hours of ingestion, initiating early cellular uptake and baseline protein clearance [1].
• ✓ Weeks 3–4: Consistent daily enzymatic activity stabilizes circulating clotting markers, supporting smoother microvascular flow and extremity warmth [3].
• ✓ Months 2–3+: Sustained vascular support promotes lasting arterial elasticity, normal blood viscosity, and balanced blood pressure [2, 4].

Physical Feel, Sensory Traits & Clean Ingredients

Pill Format & Ease of Use

Each dose comes in a compact Size '0' vegetarian capsule that swallows easily with water. We advise against opening the capsule into juice or food; swallowing the capsule intact protects the delicate enzyme from premature stomach acid degradation.

Natural Aroma, Taste & Color

Whole fermented natto food has an intense ammonia aroma. NOW® uses a refined extraction process that removes pungent odors, leaving a subtle, neutral scent. The encapsulated powder shows an authentic off-white to light beige hue with natural batch variations.

Other Ingredients Explained

• Microcrystalline Cellulose: Purified plant fiber used as an inert filler to distribute high-potency enzymes evenly across capsules.
• Hypromellose (Vegetable Capsule): A 100% plant cellulose shell that dissolves swiftly in the digestive tract without animal gelatin.
• Stearic Acid (Vegetable Source): A natural plant-derived fatty acid that lubricates encapsulation machinery for clean processing.
• Silicon Dioxide: A natural mineral compound that absorbs ambient moisture to prevent powder clumping and preserve enzyme potency.

Proper Storage

Keep the bottle tightly capped in a cool, dry pantry away from sunlight and moisture. Avoid storing supplements in humid bathroom medicine cabinets.

Manufacturer Quality & Lab Testing Standards

NOW Foods operates world-class in-house analytical laboratories accredited to ISO/IEC 17025 standards. Unlike discount brands that rely on unverified third-party brokers, NOW verifies every incoming ingredient batch with advanced scientific instruments:

• ✓ Heavy Metal Clearance via ICP-MS: Inductively Coupled Plasma Mass Spectrometry measures toxic metals—lead, cadmium, arsenic, and mercury—down to parts-per-billion (ppb) limits, surpassing strict California Proposition 65 benchmarks.
• ✓ Potency & Identity Testing via HPLC: High-Performance Liquid Chromatography verifies raw identity and confirms exact 2,000 FU active potency in every batch.
• ✓ Microbiological Safety Screening: Automated bio-burden testing confirms the complete absence of hazardous microbes, including Salmonella species, Escherichia coli, yeasts, and molds.

These comprehensive internal testing controls protect you from unlisted chemical fillers, microbial contamination, and sub-potent raw materials common among bargain mass-market brands.

Complete Supplement Facts Panel

** Daily Value not established.
FU (Fibrinolytic Units) is a standardized assay measuring enzymatic fibrin-dissolving potency.

Other Ingredients: Microcrystalline Cellulose, Hypromellose (cellulose capsule), Stearic Acid (vegetable source) and Silicon Dioxide.

Allergen Notice: Contains soy. Contains no Vitamin K. Not manufactured with wheat, gluten, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Caution: For adults only. Do not use if pregnant or nursing, taking “blood thinning” medications (anticoagulants) (such as aspirin, warfarin, heparin), or if you have any ongoing bleeding/coagulation problems (including but not limited to: active ulcer, recent surgery/trauma, hemophilia). Consult physician if you have a medical condition (including uncontrolled high blood pressure [equal to or higher than 200 mmHg/110 mmHg]). Keep out of reach of children.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Scientific References & Clinical Studies

1. Kurosawa Y, Nirengi S, Homma T, et al. "A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles." Scientific Reports, 2015;5:11601. PMID: 26109079.
2. Jensen GS, Lenninger M, Ero MP, Benson KF. "Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial." Integrated Blood Pressure Control, 2016;9:95-104. PMID: 27785095.
3. Hsia CH, Shen MC, Lin JS, et al. "Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects." Nutrition Research, 2009;29(3):190-196. PMID: 19358933.
4. Chen H, McGowan EM, Ren N, et al. "Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants." Frontiers in Cardiovascular Medicine, 2022;9:964977. PMID: 36072877.

Frequently Asked Questions

Why must I take nattokinase on an empty stomach instead of with meals?

Nattokinase is a systemic protein-digesting enzyme. If consumed with meals, the enzyme acts as a digestive aid, breaking down proteins in your food. Taking it on an empty stomach allows the active enzyme to pass into your bloodstream to clear vascular protein debris.