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Source Naturals Phosphatidyl Serine Complex 500 mg (60 Softgels)
Source Naturals Phosphatidyl Serine Complex 500 mg delivers concentrated structural phospholipids designed to support mental focus, memory retention, and everyday brain cell communication.
Key Potency Note: Each softgel contains 500 mg of standardized soybean extract, yielding 100 mg of active, bioavailable Phosphatidylserine (PS) alongside essential co-factors including phosphatidylcholine and phosphatidylethanolamine.
- ✓ Supports healthy recall, cognitive processing speed, and daily focus
- ✓ Helps maintain cellular fluid balance and neurotransmitter signaling
- ✓ Aids in moderating physical and mental stress responses by balancing cortisol release
- ✓ Stabilized softgel format free of gluten, yeast, wheat, and dairy
What Is Phosphatidylserine and How Does It Work in the Brain?
Phosphatidylserine (often abbreviated as PS) is a specialized phospholipid—a natural building block of fat and protein that forms the structural protective barrier of your brain cells (neurons). Think of your brain cells like living houses: phospholipids create the flexible walls, windows, and doors that keep harmful toxins out while allowing vital nutrients, oxygen, and communication signals to flow smoothly across the threshold.
While your body manufactures some PS internally, natural levels decline steadily with age. Supplementing with Source Naturals Phosphatidyl Serine Complex replenishes these foundational lipids, assisting with the release of key neurotransmitters—including acetylcholine (essential for memory and learning) and dopamine (vital for attention and mood).
By combining phosphatidylserine with secondary phospholipids like phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol, this stabilized complex mimics the brain's natural lipid matrix for efficient cellular absorption.
Clinical Research & Scientific Evidence
Phosphatidylserine is one of the most comprehensively researched brain nutrients in clinical literature. Research highlights its measurable impact across two primary areas of human health:
1. Memory Recall and Age-Associated Cognitive Support
In a landmark double-blind, placebo-controlled clinical trial led by Dr. Thomas Crook and published in Neurology (1991), 149 elderly subjects who consumed 100 mg of phosphatidylserine three times daily showed statistically significant improvements in learning names, faces, and phone numbers compared to the placebo control group. A subsequent multicenter trial by Cenacchi et al. (1993) across 427 participants confirmed sustained improvements in everyday cognitive performance, mental clarity, and verbal fluency.
Citations:
• Crook, T. H., et al. (1991). "Effects of phosphatidylserine in age-associated memory impairment." Neurology, 41(5), 644-649.
• Cenacchi, T., et al. (1993). "Cognitive decline in the elderly: a double-blind, multicentre study on efficacy of phosphatidylserine administration." Aging Clinical and Experimental Research, 5(2), 123-133.
2. Stress Adaptation and Cortisol Management
When mental or physical demands spike, the body produces elevated levels of the stress hormone cortisol. Clinical trials published in Nutritional Neuroscience and the European Journal of Clinical Pharmacology demonstrated that supplementing with phosphatidylserine helps blunt excessive cortisol spikes triggered by acute emotional and physical stress, fostering a calm, focused mindset under pressure.
Citations:
• Benton, D., et al. (2001). "The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor." Nutritional Neuroscience, 4(3), 169-178.
• Monteleone, P., et al. (1992). "Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in man." European Journal of Clinical Pharmacology, 42(4), 385-388.